Synthesis of Diazatricyclic Molecules via Intramolecular Cycloaddition of Azomethine Ylides Reviewed Open Access

S. Kato, K. Morita, N. Umekubo, S. Yokoshima

Org. Lett.     2025.9

Synthesis of 2,6-Diazabicyclo[3.3.1]nonanes via Intramolecular Cycloaddition of Nitrones Reviewed Open Access

R. Kawai, A. Nakamuira, Y. Irie, N. Umekubo, S. Yokosima

Org. Biomol. Chem.     2025.8

Stereoselective Synthesis of Delgocitinib and Its Diastereomer Using Organocatalyzed Michael Addition Reviewed Open Access

K. Morita, N. Umekubo, H. Matsuzaki, K. Tsutsumi, S. Yokoshima

Org. Lett.   Vol. 27   page： 6789 - 6793   2025.7

Construction of Nitrogen-Containing Three-Dimensional Frameworks via Formation and Cycloaddition of endo-Cyclic Azomethine Ylide Reviewed Open Access

K. Furuhashi, N. Umekubo, Y. Matsuyuki, S. Yokoshima

Org. Lett.   Vol. 27   page： 4904 - 4908   2025.5

Total Synthesis of Melonine Reviewed

Y. Matsuyuki, N. Umekubo, S. Yokoshima

Org. Lett.   Vol. 27   page： 2065 - 2068   2025.2

Organocatalyst-mediated asymmetric one-pot/two domino/three-component coupling reactions for the synthesis of trans-hydrindanes Reviewed Open Access

N. Mori, T. Tachibana, N. Umekubo, Y. Hayashi

Chem. Sci.,   Vol. 15   page： 5627 - 5632   2024.3

Deep learning driven de novo drug design based on gastric proton pump structures Invited Reviewed Open Access

  Vol. 6   page： 956   2023.9

Total syntheses of macleanine and lycoposerramine-S Reviewed Open Access

M. Okuyama, N. Umekubo, K. Akimoto, T. Shimizu, K. Kubokoya, N. Nakajima, Y. Nishiyama, S. Yokoshima

Org. Biomol. Chem.   Vol. 21   page： 6289 - 6292   2023.7

Total Synthesis of Kopsone Reviewed

Kazutoshi Tomoya , Kazuaki Komiya, Daisuke Nakajima, Nariyoshi Umekubo, Satoshi Yokoshima

Organic Letters   Vol. 25 ( 25 ) page： 2718 - 2721   2023.4

Diphenylprolinol Silyl Ether Catalyzed Asymmetric Formal Carbo [3+3] Cycloaddition Reaction of Isopropylidenemalononitrile and α,β-Unsaturated Aldehyde Reviewed

Nariyoshi Umekubo, Xiaolei Han, Naoki Mori, Yujiro Hayashi

European Journal of Organic Chemistry   ( 26 ) page： e202200603   2022.6

Catalytic Asymmetric Michael Reaction of Methyl Alkynyl Ketone Catalyzed by Diphenylprolinol Silyl Ether Invited Reviewed Open Access

Nariyoshi Umekubo, Yujiro Hayashi

ACS Organic & Inorganic Au   Vol. 2 ( 3 ) page： 245 - 251   2022.1

Asymmetric Synthesis of Pentasubstituted Cyclohexanes through Diphenylprolinol Silyl Ether Mediated Domino Michael/Michael Reaction Reviewed

Amaechi Shedrack Odoh, Louise Aidanpää, Nariyoshi Umekubo, Hiroaki Matoba, Naoki Mori, Yujiro Hayashi

Eur. J. Org. Chem.     2021.10

Synthesis of Bicyclo[2.2.2]octanes with a Quaternary Bridgehead Carbon by Diphenylprolinol Silyl Ether-mediated Domino Reaction Reviewed

Nariyoshi Umekubo, Tohru Taniguchi, Kenji Monde, Yujiro Hayashi

Asian. J. Org. Chem.     2021.10

Asymmetric Domino Reaction of α,β-Unsaturated Aldehydes and α-Acyl α,β-Unsaturated Cyclic Ketones Catalyzed by Diphenylprolinol Silyl Ether Invited Reviewed

Yujiro Hayashi, Yurina Suga, Nariyoshi Umekubo

Org. Lett.     2020.10

Evidence for an enolate mechanism in the asymmetric Michael reaction of α,β-unsaturated aldehydes and ketones via a hybrid system of two secondary amine catalysts Reviewed Open Access

Nariyoshi Umekubo, Takahiro Terunuma, Eunsang Kwon, Yujiro Hayashi

Chem. Sci.     2020.9

Asymmetric Synthesis of Corey Lactone and Latanoprost Reviewed

Nariyoshi Umekubo, Yujiro Hayashi

Eur. J. Org. Chem.     2020.8

Asymmetric One-Pot Mukaiyama Michael/Michael Reaction Catalyzed by Diphenylprolinol Silyl Ether Reviewed

Nariyoshi Umekubo, Yujiro Hayashi

Eur. J. Org. Chem.     2020.7

One-pot Synthesis of Chiral cis-Hydrindanes via Diphenylprolinol Silyl Ether Mediated Domino Reaction and Aldol Condensation Reviewed

Nariyoshi Umekubo, Ryohei Iwata, Yujiro Hayashi

Chem. Lett.     2020.4

Prolinate Salts as Catalysts for α-Aminoxylation of Aldehyde and Associated Mechanistic Insights Reviewed

Yujiro Hayashi, Taku Hirama, Nariyoshi Umekubo

Org. Lett.     2017.8