Updated on 2022/01/06

写真a

 
NAKANISHI Koki
 
Organization
Nagoya University Hospital Gastroenterological Surgery 2 Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. 博士(医学) ( 2021.3   名古屋大学 ) 

Research Interests 6

  1. 臨床腫瘍学

  2. 胃癌

  3. 消化器癌

  4. 消化器外科

  5. 分子生物学

  6. トランスレーショナルリサーチ

Research Areas 3

  1. Life Science / Tumor diagnostics and therapeutics

  2. Life Science / Tumor biology  / 分子腫瘍学

  3. Life Science / Digestive surgery

Research History 3

  1. 名古屋大学医学部附属病院消化器外科二 医員

    2018.4

  2. 国立研究開発法人国立がん研究センター中央病院

    2015.4 - 2018.3

  3. 小牧市民病院

    2009.4 - 2015.3

Committee Memberships 1

  1. JCOG胃癌グループ   若手の会「JCOG-Sync.」幹事  

    2021.4   

Awards 2

  1. Nishi Memorial Award

    2020.3   Japanese Gastric Cancer Association  

  2. 優秀演題賞

    2019.10   The 57th anual meeting of japan society of clinical oncology   Influence of delayed administration of postoperative adjuvant S-1 monotherapy for gastric cancer -Analysis of a multi-institutional dataset-

    Koki Nakanishi

 

Papers 15

  1. E-PASS scoring system serves as a predictor of short- and long-term outcomes in gastric cancer surgery.

    Koki Nakanishi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Daisuke Kobayashi, Dai Shimizu, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Surgery today     2021.10

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    PURPOSES: This study aimed to evaluate the estimation of the physiological ability and surgical stress (E-PASS) scoring system for predicting the short- and long-term outcomes in gastric cancer (GC) surgery. METHODS: We analyzed a multi-institutional dataset to study patients who underwent gastrectomy with a curative intent between 2010 and 2014. This study evaluated the associations between the optimal E-PASS score cutoff value and the following outcomes: (1) the incidence of postoperative complications in stage I-III GC patients and (2) the prognosis in stage II-III GC patients. RESULTS: A total of 2495 GC patients were included. A cutoff value of 0.419 was determined using the ROC curve analysis. Postoperative complications were observed more frequently in the E-PASS-high group than that in the E-PASS-low group (30% vs. 17%, p < 0.0001). Among pStage II-III GC patients (n = 1009), the overall survival time of the E-PASS-high group was significantly shorter than that of the E-PASS-low group (hazard ratio 2.08; 95% confidence interval 1.64-2.65; p < 0.0001). A forest plot revealed that E-PASS-high was associated with a greater prognostic factor for overall survival in most subgroups. CONCLUSIONS: The E-PASS scoring system may therefore be a useful predictor of the short- and long-term outcomes in patients with GC who have undergone radical gastrectomy.

    DOI: 10.1007/s00595-021-02394-3

    PubMed

  2. Prognostic impact of a microscopic positive margin in patients undergoing gastrectomy for gastric cancer: a propensity score‑matched analysis of a multi‑institutional dataset.

    Koki Nakanishi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Dai Shimizu, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Surgery today     2021.8

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    PURPOSE: We analyzed the effect of a microscopic positive margin on survival outcomes after gastrectomy for gastric cancer METHODS: We analyzed a multi-institutional dataset to study patients who underwent gastrectomy with curative intent between 2010 and 2014. We used propensity score matching to strictly balance the patients' oncological features, backgrounds, and postoperative treatment to compare the survival outcomes of those with microscopic positive margins and those with negative margins. RESULTS: Among 3029 patients, 32 (1.1%) had positive margins. After matching, we enrolled 128 patients in this retrospective analysis: 32 with a positive margin and 96 with a negative margin. The recurrence-free survival of the positive-margin group was significantly shorter than that of the negative-margin group (hazard ratio [HR], 1.62, 95% confidence interval, 1.00-2.63, p = 0.0485). Consistent results were observed for patients with pStages I-III disease (HR, 1.65, p = 0.0835), whereas the survival curves overlapped in those with pStage IV disease (HR, 1.29, p = 0.5934). The prevalence of overall recurrence in the positive-margin group was higher than that in the negative-margin group (75% vs 58%, p = 0.0917). This trend was consistent with locoregional recurrence (9% vs 3%) and distant recurrence (69% vs 55%). CONCLUSIONS: The survival of patients after curative gastrectomy for gastric cancer was worse in those with microscopic positive margins than in those with negative margins.

    DOI: 10.1007/s00595-021-02365-8

    PubMed

  3. Accurate Prediction of Prognosis After Radical Resection of Gastric Cancer by the Modified Systemic Inflammation Score; a Multicenter Dataset Analysis. International journal

    Kota Inagaki, Mitsuro Kanda, Koki Nakanishi, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    World journal of surgery   Vol. 45 ( 8 ) page: 2513 - 2520   2021.5

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    BACKGROUND: The presence of chronic inflammation and nutritional status in cancer patients affects its prognosis. There is a clinical need for a prognostic predictor that is objective and accurate, and that can be easily evaluated by preoperative screening. We evaluated the importance and usefulness of the preoperative modified systemic inflammation score (mSIS) to predict the long-term outcome of patients undergoing curative resection for gastric cancer (GC). METHODS: Of the 3571 patients who underwent curative resection for GC in nine institutions between January 2010 and December 2014, 1764 patients who met the inclusion criteria were included. The mSIS was formulated according to the serum albumin level (ALB) and lymphocyte-to-monocyte ratio (LMR) as follows: mSIS 0 (ALB ≥ 4.0 g/dL and LMR ≥ 3.4), mSIS 1 (ALB < 4.0 g/dL or LMR < 3.4), and mSIS 2 (ALB < 4.0 g/dL and LMR < 3.4). RESULTS: Patients were categorized into preoperative mSIS 0 (n = 955), mSIS 1 (n = 584), and mSIS 2 (n = 225) groups. The overall survival times and the disease-free survival times of patients in preoperative mSIS 0,1 and 2 sequentially shortened (P < 0.0001), and mSIS 1 and 2 were identified as an independent prognostic factor (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.06-1.272, P = 0.0125 and HR 1.63, 95% CI 1.21-2.19, P = 0.0012). A stepwise increase in the prevalence of hematogenous recurrences was directly proportional to the mSIS. A forest plot revealed that mSIS 0,1 was associated with a greater risk of overall survival in most subgroups. CONCLUSION: Preoperative mSIS can be easily calculated, and it is suggested that it is useful as a prognostic predictor of patients with different disease stages, for stratifying and evaluating clinical outcomes.

    DOI: 10.1007/s00268-021-06138-9

    PubMed

  4. Short-term outcomes of gastrectomy after neoadjuvant chemotherapy for clinical stage III gastric cancer: propensity score-matched analysis of a multi-institutional database.

    Shinichi Umeda, Mitsuro Kanda, Koki Nakanishi, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Dai Shimizu, Daisuke Kobayashi, Chie Tanaka, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Surgery today   Vol. 51 ( 5 ) page: 821 - 828   2020.11

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    PURPOSE: Preoperative chemotherapy for gastric cancer may be effective from the standpoint of compliance, although there is insufficient evidence of its efficacy. We analyzed a multicenter database to clarify whether preoperative chemotherapy influenced the short-term outcomes of gastrectomy. METHODS: We analyzed, retrospectively, 3571 patients who underwent gastrectomy between January, 2010 and December, 2014. Patients with clinical stage-III gastric adenocarcinoma were divided into a neoadjuvant chemotherapy (NAC) group and a non-NAC group. We performed propensity-matched comparative analysis to stratify the groups according to age, sex, tumor region, tumor type, preoperative stage, procedure, lymph node dissection, and tumor differentiation. Preoperative blood data, surgical findings, and postoperative complications were analyzed. RESULTS: Analysis of the matched NAC (n = 64) and non-NAC (n = 128) groups revealed that the preoperative values of neutrophils, platelets, and Hb were significantly lower in the NAC group. Blood loss during surgery was significantly higher, surgical times were longer, and the rate of repeat surgery was significantly lower in the NAC group; however, the rates of rehospitalization did not differ between the groups and mortality was 0% in both groups. Postoperative complications were not significantly different between the groups. CONCLUSIONS: NAC did not increase the complication rate of gastrectomy for gastric cancer.

    DOI: 10.1007/s00595-020-02179-0

    PubMed

  5. Is the measurement of drain amylase content useful for predicting pancreas-related complications after gastrectomy with systematic lymphadenectomy? Reviewed International journal

    Koki Nakanishi, Mitsuro Kanda, Junichi Sakamoto, Yasuhiro Kodera

    World journal of gastroenterology   Vol. 26 ( 14 ) page: 1594 - 1600   2020.4

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    Many studies investigating postoperative pancreatic fistula (POPF) after gastrectomy, including studies measuring drain amylase content (D-AMY) as a predictive factor have been reported. This article reviews previous studies and looks to the future of measuring D-AMY in patients after gastrectomy. The causes of pancreatic fluid leakage are; the parenchymal and/or thermal injury to the pancreas, and blunt injury to the pancreas by compression and retraction. Measurement of D-AMY to predict POPF has become common in clinical practice after pancreatic surgery and was later extended to the gastric surgery. Several studies have reported associations between D-AMY and POPF after gastrectomy, and the high value of D-AMY on postoperative day (POD) 1 was an independent risk factor. To improve both sensitivity and specificity, attempts have been made to enhance the predictive accuracy of factors on POD 1 as well as on POD 3 as combined markers. Although several studies have shown a high predictive ability of POPF, it has not necessarily been exploited in clinical practice. Many problems remain unresolved; ideal timing for measurement, optimal cut-off value, and means of intervention after prediction. Prospective clinical trial could be imperative in order to develop D-AMY measurement in common clinical practice for gastric surgery.

    DOI: 10.3748/wjg.v26.i14.1594

    PubMed

  6. ASO Author Reflections: Diagnostic Accuracy of Intraoperative Margin Assessment by Frozen Section in Gastric Cancer. Reviewed International journal

    Koki Nakanishi, Shinji Morita, Hitoshi Katai

    Annals of surgical oncology   Vol. 26 ( Suppl 3 ) page: 688 - 689   2019.12

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    DOI: 10.1245/s10434-019-07718-9

    PubMed

  7. Delay in initiation of postoperative adjuvant chemotherapy with S-1 monotherapy and prognosis for gastric cancer patients: analysis of a multi-institutional dataset. Reviewed

    Koki Nakanishi, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association   Vol. 22 ( 6 ) page: 1215 - 1225   2019.11

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    BACKGROUND: This study aimed to evaluate whether the timing of initiating postoperative chemotherapy with S-1 monotherapy affects gastric cancer patients' prognosis. METHODS: A multi-institution dataset identified patients with pStage II or III gastric cancer who received S-1 monotherapy for over 6 months after curative resection between 2010 and 2014. Patients were divided into three groups based on the timing of S-1 monotherapy initiation. Prognostic factors for relapse-free survival (RFS) were investigated. RESULTS: We classified 401 patients into groups as follows: S-1 administered within 6 weeks (n = 247), between 6 and 8 weeks (n = 95), and after 8 weeks (n = 59). The RFS times were not significantly different in the within 6 weeks group and the between 6 and 8 weeks group, but the after 8 weeks group had a shorter RFS time compared with the other two groups (within 6 weeks group vs. after 8 weeks group; P = 0.0044). By disease stage, this trend was the same. The multivariable analysis showed that a larger tumor size (≥ 50 mm), pStage III, and the after 8 weeks group were independent prognostic factors for RFS (after 8 weeks group: hazard ratio, 2.05; P = 0.0069). The prevalence of hematogenous metastasis as the initial recurrence site increased by delayed initiation of S-1. A forest plot revealed that delayed administration after 8 weeks was associated with a greater risk of recurrence in most subgroups. CONCLUSIONS: Postoperative chemotherapy with S-1 monotherapy for gastric cancer is recommended to begin within 8 weeks after surgery.

    DOI: 10.1007/s10120-019-00961-9

    PubMed

  8. Reply to "Utility of Intraoperative Margin Assessment by Frozen Section in Gastric Cancer". Reviewed International journal

    Koki Nakanishi, Shinji Morita, Hirokazu Taniguchi, Sho Otsuki, Takeo Fukagawa, Hitoshi Katai

    Annals of surgical oncology   Vol. 26 ( 11 ) page: 3784 - 3784   2019.10

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    DOI: 10.1245/s10434-019-07572-9

    PubMed

  9. Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer. Reviewed

    Nakanishi K, Kanda M, Kodera Y

    World journal of gastroenterology   Vol. 25 ( 22 ) page: 2743 - 2751   2019.6

  10. The levels of SYT13 and CEA mRNAs in peritoneal lavages predict the peritoneal recurrence of gastric cancer. Reviewed

    Nakanishi K, Kanda M, Umeda S, Tanaka C, Kobayashi D, Hayashi M, Yamada S, Kodera Y

    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association     2019.5

  11. Diagnostic Accuracy and Usefulness of Intraoperative Margin Assessment by Frozen Section in Gastric Cancer. Reviewed International journal

    Nakanishi K, Morita S, Taniguchi H, Otsuki S, Fukagawa T, Katai H

    Annals of surgical oncology   Vol. 26 ( 6 ) page: 1787 - 1794   2019.3

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    BACKGROUND: Intraoperative frozen examination is clinically important for negative margin confirmation in cancer surgery. We investigated the diagnostic accuracy of frozen-section assessment and risk factors for positive resection margins by studying gastric cancer specimens from 1115 patients treated at our hospital. METHODS: The results of gastric cancer patients who had undergone intraoperative margin assessment, employing frozen examination, with curative intent in our unit between 2000 and 2017 were retrospectively analyzed. Frozen section assessments were compared with the corresponding permanent section assessments to evaluate the accuracy, sensitivity, and specificity of the former. The causes of discordances between two assessments were examined. In addition, risk factors associated with positive margins were identified. RESULTS: In total, 1241 specimens were obtained from the 1115 patients. The accuracy, sensitivity, and specificity of frozen-section assessments were 99.4%, 99.5%, and 97.8%, respectively. There were eight discordant cases. Two false-negative cases required another gastrectomy after final pathological diagnosis because of missed neoplastic cells. Six false-positive cases underwent unnecessary additional resection due to false positive results. In our frozen series, 89 cases had a positive margin on permanent section. Multivariate regression analysis of patients with positive surgical margins revealed large diameter (≥ 50 mm) and T4 tumor to be independent risk factors. CONCLUSIONS: Intraoperative frozen examination is a highly accurate method that is useful for achieving negative margins. This procedure is especially recommended for patients with a tumor larger than 50 mm in maximum diameter or serosal invasion to confirm a negative margin.

    DOI: 10.1245/s10434-019-07302-1

    PubMed

  12. Multiple rapidly growing desmoid tumors that were difficult to distinguish from recurrence of rectal cancer Reviewed

    Koki Nakanishi, Dai Shida, Shunsuke Tsukamoto, Hiroki Ochiai, Junichi Mazaki, Hirokazu Taniguchi, Yukihide Kanemitsu

    WORLD JOURNAL OF SURGICAL ONCOLOGY   Vol. 15 ( 1 )   2017.10

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    Background: Intra-abdominal desmoid tumors are usually slow growing and solitary, but multifocal desmoid tumors develop on rare occasions. Diagnosing desmoid tumors before histological examination of a surgical biopsy is often difficult. In particular, if a patient has a prior history of malignancy, it may be difficult to differentiate between these lesions and disease recurrence or metastasis.
    Case presentation: We present a rare case of multiple rapidly growing intra-abdominal desmoid tumors after surgical trauma, without familial adenomatous polyposis. A 51-year-old male underwent abdominal perineal resection with lateral lymph node dissection after neoadjuvant chemotherapy for lower rectal cancer. Follow- up computed tomography (CT), performed 6 months after primary surgery, showed a 20-mm solitary mass in the pelvic mesentery. Another CT scan, performed 3 months later, revealed that the mass had grown to 35 mm in size and that two new masses had formed. Based on imaging studies and his medical history, it was difficult to distinguish the desmoid tumors from recurrence of rectal cancer. Curative resection was chosen for therapeutic diagnosis. The pathological diagnosis was multiple mesenteric desmoid tumors.
    Conclusions: Desmoid tumors should not be excluded as a differential diagnosis for intra-abdominal masses after intra-abdominal surgery, even in cases of rapidly growing multiple masses.

    DOI: 10.1186/s12957-017-1248-7

    Web of Science

  13. Successful Percutaneous Transhepatic Removal of an Internal Plastic Stent Migrated into the Intrahepatic Bile Duct after Pancreatoduodenectomy Reviewed

    Nakanishi Koki, Arai Yasuaki, Sone Miyuki, Sulaiman Norshazriman, Esaki Minoru, Shimada Kazuaki

    Interventional Radiology   Vol. 2 ( 1 ) page: 19   2017

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    Publisher:Japanese Society of Interventional Radiology  

    DOI: 10.22575/interventionalradiology.2.1_19

  14. Phase II multi-institutional prospective randomized trial comparing S-1 plus paclitaxel with paclitaxel alone as second-line chemotherapy in S-1 pretreated gastric cancer (CCOG0701) Reviewed

    Koki Nakanishi, Daisuke Kobayashi, Yoshinari Mochizuki, Kiyoshi Ishigure, Seiji Ito, Hiroshi Kojima, Akiharu Ishiyama, Shinichi Fujitake, Toshio Shikano, Satoshi Morita, Yasuhiro Kodera

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   Vol. 21 ( 3 ) page: 557 - 565   2016.6

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    The aim of this study was to explore whether a combination of S-1 and paclitaxel offers any benefit over paclitaxel alone to patients pretreated by S-1.
    Gastric cancer patients who developed progression during S-1-based first-line chemotherapy or had recurrence during postoperative adjuvant chemotherapy by S-1 were randomly assigned to receive second-line treatment either by weekly administration of paclitaxel at 80 mg/m(2) three times every 4 weeks or daily oral S-1 (80 mg/m(2)) for 2 weeks plus paclitaxel (50 mg/m(2)) given on days 1 and 8, every 3 weeks (S-1 plus paclitaxel). The primary endpoint was progression-free survival (PFS) at 4 months after the initiation of treatment.
    A total of 78 patients were eligible for efficacy analyses-40 were assigned to the paclitaxel group and 38 to the S-1 plus paclitaxel group. PFS at 4 months was similar between the groups (50 % for paclitaxel vs 55 % for S-1 plus paclitaxel, P = 0.641). There were no differences between the groups either in progression-free survival (4.6 vs 4.6 months, respectively, P = 0.526), overall survival (10.0 vs 10.0 months, respectively, P = 0.464), or overall response rate (27 vs 22 %, respectively, P = 0.767). The incidences of grade 3 or 4 hematological and non-hematological toxicities were also equivalent between the two groups (25 vs 26 % and 24 vs 26 %, respectively).
    No benefit of S-1 administration beyond progression was shown when paclitaxel was selected as the key drug for second-line chemotherapy.

    DOI: 10.1007/s10147-015-0919-z

    Web of Science

  15. ポリスチレンスルホン酸カルシウム (アーガメイトゼリー®) 内服中に大腸穿孔をきたした 3 例 Reviewed

    中西香企, 谷口健次, 田中健士郎, 平田伸也, 園原史訓, 神崎章之, 横山裕之, 望月能成

    日本腹部救急医学会雑誌   Vol. 35 ( 3 ) page: 355 - 359   2015.3

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    DOI: 10.11231/jaem.35.355

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MISC 40

  1. E-PASS scoring systemによる胃癌術後短期・長期予後予測能の有用性の検討

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 清水 大, 田中 千恵, 藤原 道隆, 小寺 泰弘

    日本消化器外科学会総会   Vol. 76回   page: P153 - 1   2021.7

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  2. 高齢者胃癌における術後長期成績の予測因子としてのE-PASS scoring systemの有用性

    山本 泰康, 中西 香企, 橋本 良二

    日本消化器外科学会総会   Vol. 76回   page: S14 - 2   2021.7

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  3. 高齢者胃癌に対する治療の工夫 高齢者胃癌手術症例に対する高齢者機能の転帰と工夫

    田中 千恵, 中西 香企, 清水 大, 服部 憲史, 神田 光郎, 中山 吾郎, 小池 聖彦, 小寺 泰弘

    日本消化器外科学会総会   Vol. 76回   page: WS10 - 9   2021.7

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  4. 【消化器癌;診断と治療のすべて】消化器癌の診断・病期分類・治療・成績 消化管GIST 外科治療と成績

    田中 千恵, 中西 香企, 小寺 泰弘

    消化器外科   Vol. 44 ( 6 ) page: 796 - 802   2021.5

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  5. Gastrointestional stromal tumor: Surgical treatment and outcomes

    田中千恵, 中西香企, 小寺泰弘

    消化器外科   Vol. 44 ( 6 ) page: 796 - 802   2021.5

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    J-GLOBAL

  6. 胃癌において切除断端の顕微鏡的癌遺残は予後因子となりうるか?

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 松下 英信, 清水 大, 田中 千恵, 藤原 道隆, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 121回   page: PS - 4   2021.4

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  7. StageIII胃癌に対する術前化学療法後胃切除術の短期成績の検討(Short-term outcomes of gastrectomy after neoadjuvant chemotherapy for stage III gastric cance)

    梅田 晋一, 神田 光郎, 中西 香企, 清水 大, 田中 千恵, 藤原 道隆, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 93回   page: 288 - 288   2021.3

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  8. Tumor detection using indocyanine green fluorescence during gastrectomy for gastric cancer

    田中千恵, 神田光郎, 佐藤敏, 中西香企, 清水大, 藤原道隆, 小寺泰弘

    日本胃癌学会総会記事   Vol. 93回   page: 219 - 219   2021.3

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    J-GLOBAL

  9. 顕微鏡的断端陽性が予後に与える影響(Microscopic Positive Margin After Gastrectomy Increases Recurrences of Gastric Cancer)

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 清水 大, 田中 千恵, 藤原 道隆, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 93回   page: 259 - 259   2021.3

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  10. 胃癌において切除断端の顕微鏡的癌遺残は予後因子となりうるか?

    中西香企, 神田光郎, 伊藤誠二, 望月能成, 寺本仁, 石榑清, 村井俊文, 浅田崇洋, 石山聡治, 松下英信, 清水大, 田中千恵, 藤原道隆, 小寺泰弘

    日本外科学会定期学術集会(Web)   Vol. 121st   page: PS - 4   2021

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    J-GLOBAL

  11. 地方中規模一般病院における外来化学療法への薬剤師業務の必要性と費用対効果に関する一考察

    隅田 美紀, 田口 多栄子, 吾妻 祐哉, 中西 香企, 小木曽 正輝, 関谷 正徳

    日本病院薬剤師会雑誌   Vol. 56 ( 12 ) page: 1438 - 1444   2020.12

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    外来化学療法への薬剤師業務が推進されているが、地方中規模一般病院での費用対効果は明らかではない。そこで、中津川市民病院(以下、当院)の外来化学療法室において2018年8月1日〜2019年7月31日の1年間に薬剤師が主治医に薬物療法に関する提案あるいは情報提供(薬学的介入)を行った内容を後向きに調査した。期間中に行った薬剤管理指導は1,067件であり、薬学的介入が294件、受諾率は88.1%であった。そのうち抗がん剤に関する提案は192件、その他の併用薬に関する提案が69件であった。田坂らによる推算を用いると、薬学的介入による医療経済効果は年間11,032,000円と考えられる。一方で、がん患者指導管理料3による収益は684,000円であった。外来化学療法の薬剤管理指導は、現在はその収益で補うことはできていないが、安全性・有効性の確保と医療訴訟の回避により病院を損失から守り、かつ医療経済効果は高いと考える。(著者抄録)

  12. 胃癌における周術期化学療法の新知見 胃癌に対するS-1補助療法の臨床問題に答えるための多施設データセット解析(New findings on perioperative chemotherapy for gastric cancer Multi-institutional dataset analysis to answer clinical questions of adjuvant S-1 for gastric cancer)

    Nakanishi Koki, Kanda Mitsuro, Ito Seiji, Mochizuki Yoshinari, Teramoto Hitoshi, Ishigure Kiyoshi, Shimizu Dai, Tanaka Chie, Fujiwara Michitaka, Kodera Yasuhiro

    日本消化器外科学会総会   Vol. 75回   page: WS4 - 6   2020.12

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  13. 幽門側胃切除術後の再建法が術後合併症に及ぼす影響 B-I法とR-Y法の比較

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 松下 英信, 清水 大, 田中 千恵, 小林 大介, 藤原 道隆, 室谷 健太, 小寺 泰弘

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 6   2020.8

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  14. 当院における消化器外科領域のCALNA参入と現状について

    宮田 一志, 深谷 昌秀, 山崎 健太, 石井 健太, 冨永 健太, 西村 康大, 小池 聖彦, 小林 大介, 田中 千恵, 神田 光郎, 清水 大, 佐藤 敏, 中西 香企, 江畑 智希, 小寺 泰弘, 梛野 正人

    日本外科学会定期学術集会抄録集   Vol. 120回   page: SF - 7   2020.8

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  15. 今後の胃癌バイオマーカー 胃癌腹膜播種再発を予測する腹膜洗浄液中の分子バイオマーカー(Upcoming biomarkers for gastric cancer Molecular biomarkers in peritoneal lavages to predict the peritoneal recurrences of gastric cancer)

    Kanda Mitsuro, Nakanishi Koki, Tanaka Chie, Kobayashi Daisuke, Shimizu Dai, Sonohara Fuminori, Takami Hideki, Inokawa Yoshikuni, Hattori Norifumi, Hayashi Masamichi, Yamada Suguru, Nakayama Goro, Koike Masahiko, Fujiwara Michitaka, Kodera Yasuhiro

    日本胃癌学会総会記事   Vol. 92回   page: 233 - 233   2020.3

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  16. 胃癌手術のエビデンスと実際のデータ 基礎 幽門側胃切除後のBillroth I再建法とRoux-en-Y再建法に関する術後合併症の比較(Evidences and real world data of gastric cancer surgery: Basic Billroth I vs Roux-en-Y after distal gastrectomy in postoperative complications)

    Nakanishi Koki, Kanda Mitsuro, Ito Seiji, Mochizuki Yoshinari, Teramoto Hitoshi, Ishigure Kiyoshi, Murai Toshifumi, Asada Takahiro, Ishiyama Akiharu, Matsushita Hidenobu, Shimizu Dai, Tanaka Chie, Kobayashi Daisuke, Fujiwara Michitaka, Kodera Yasuhiro

    日本胃癌学会総会記事   Vol. 92回   page: 214 - 214   2020.3

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  17. 分子生物学的手法を応用した微小腹腔内遊離胃癌細胞検出法

    中西 香企, 神田 光郎, 梅田 晋一, 田中 千恵, 小林 大介, 林 真路, 服部 憲史, 高見 秀樹, 園原 史訓, 山田 豪, 中山 吾郎, 小池 聖彦, 藤原 道隆, 小寺 泰弘

    日本消化器外科学会雑誌   Vol. 52 ( Suppl.2 ) page: 102 - 102   2019.11

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  18. 胃癌のおけるS-1術後補助化学療法開始時期と予後との関係 多施設統合データベース

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 松下 英信, 田中 千恵, 小林 大介, 藤原 道隆, 小寺 泰弘

    日本癌治療学会学術集会抄録集   Vol. 57回   page: O56 - 1   2019.10

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  19. 術前シミュレーション・術中ナビゲーションを駆使した消化管手術 II.胃 1)腹腔鏡下胃切除術におけるシミュレーションとナビゲーションの現状と取り組み

    田中千恵, 藤原道隆, 田中由浩, 中西香企, 小寺泰弘

    手術   Vol. 73 ( 9 ) page: 1297 - 1303   2019.8

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  20. 胃癌に対するS-1術後補助化学療法の開始時期と予後に関する検討

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 小寺 泰弘

    日本消化器外科学会総会   Vol. 74回   page: P75 - 3   2019.7

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  21. 胃癌に対するS-1術後補助化学療法の開始時期と予後に関する検討

    中西 香企, 神田 光郎, 伊藤 誠二, 望月 能成, 寺本 仁, 石榑 清, 村井 俊文, 浅田 崇洋, 石山 聡治, 小寺 泰弘

    日本消化器外科学会総会   Vol. 74回   page: P75 - 3   2019.7

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  22. Intraoperative complications in the laparoscopic total/proximal gastrectomy

    田中 千恵, 中西 香企, 小寺 泰弘

    臨床外科 = Journal of clinical surgery   Vol. 74 ( 4 ) page: 427 - 430   2019.4

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  23. 幽門側胃切除術後再建法としてのB-I法とR-Y法の比較-術後早期合併症の観点から-

    中西香企, 神田光郎, 伊藤誠二, 望月能成, 寺本仁, 清水大, 田中千恵, 小林大介, 藤原道隆, 小寺泰弘

    胃外科・術後障害研究会プログラム・抄録集   Vol. 49th   2019

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  24. 腹腔鏡手術におけるICG蛍光法を用いた術前マーキングの経験

    中西香企, 田中千恵, 神田光郎, 小林大介, 林真路, 服部憲史, 高見秀樹, 園原史訓, 山田豪, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

    東海外科学会   Vol. 297th   page: 34‐35   2019

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  25. 下部直腸癌におけるMRIを用いたDME、CRM術前診断精度の検討

    中西 香企, 塚本 俊輔, 志田 大, 落合 大樹, 山田 和之介, 谷口 浩和, 三宅 基隆, 金光 幸秀

    日本外科学会定期学術集会抄録集   Vol. 118回   page: 941 - 941   2018.4

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  26. 胃癌における切除断端の術中迅診断精度の検討(Diagnostic accuracy of intraoperative margin assessment in gastric cancer surgery)

    中西 香企, 森田 信司, 伊藤 麻衣子, 佐藤 雄哉, 由良 昌大, 大槻 将, 深川 剛生, 谷口 浩和, 片井 均

    日本胃癌学会総会記事   Vol. 90回   page: 285 - 285   2018.3

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  27. 胃癌における切除断端の術中迅診断精度の検討(Diagnostic accuracy of intraoperative margin assessment in gastric cancer surgery)

    中西 香企, 森田 信司, 伊藤 麻衣子, 佐藤 雄哉, 由良 昌大, 大槻 将, 深川 剛生, 谷口 浩和, 片井 均

    日本胃癌学会総会記事   Vol. 90回   page: 285 - 285   2018.3

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  28. 胃切除術後縫合不全症例におけるHMB・アルギニン・グルタミン配合飲料の効果を調べる多施設共同第II相試験(プロトコル)

    中西香企, 神田光郎, 田中千恵, 小林大介, 林真路, 山田豪, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

    胃外科・術後障害研究会プログラム・抄録集   Vol. 48th   page: 132   2018

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  29. 術前Systemic Inflammation Scoreの進行胃癌切除術後短期および長期成績との関連性

    中西香企, 神田光郎, 田中千恵, 小林大介, 林真路, 山田豪, 中山吾郎, 小池聖彦, 藤原道隆, 小寺泰弘

    胃外科・術後障害研究会プログラム・抄録集   Vol. 48th   page: 125   2018

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  30. 当院における腎腫瘍に対する画像ガイド下経皮的凍結療法についての後ろ向き検討

    藤原 圭史, 荒井 保明, 菅原 俊祐, 曽根 美雪, 冨田 晃司, 中西 香企

    IVR: Interventional Radiology   Vol. 31 ( Suppl. ) page: 184 - 184   2016.4

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  31. 椎体以外へ施行した骨形成術の安全性と有効性についての検討

    冨田 晃司, 荒井 保明, 曽根 美雪, 菅原 俊祐, 藤原 圭史, 中西 香企

    IVR: Interventional Radiology   Vol. 31 ( Suppl. ) page: 232 - 232   2016.4

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  32. クエン酸マグネシウム服用後に高Mg血症と大腸イレウスをきたした1例

    田中 健士郎, 横山 裕之, 大津 智尚, 上嶋 三千年, 笹原 正寛, 鈴木 雄之典, 平田 伸也, 中西 香企, 森 憲彦, 佐藤 雄介, 間下 優子, 井戸田 愛, 村上 弘城, 神崎 章之, 望月 能成, 谷口 健次

    日本臨床外科学会雑誌   Vol. 76 ( 10 ) page: 2607 - 2607   2015.10

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  33. 乳房内出血をともなった乳癌の1例

    間下 優子, 井戸田 愛, 田中 健士郎, 大津 智尚, 笹原 正寛, 上嶋 三千年, 鈴木 雄之典, 平田 伸也, 中西 香企, 森 憲彦, 佐藤 雄介, 村上 弘城, 神崎 章之, 横山 裕之, 望月 能成, 谷口 健次

    日本臨床外科学会雑誌   Vol. 76 ( 10 ) page: 2606 - 2606   2015.10

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  34. 右水腎症にて発見された小腸間膜原発デスモイド腫瘍の1切除例

    植村 友稔, 中西 香企, 大津 智尚, 田中 健士郎, 坪内 秀樹, 笹原 正寛, 上嶋 三千年, 平田 伸也, 鈴木 雄之典, 森 憲彦, 佐藤 雄介, 間下 優子, 井戸田 愛, 神崎 章之, 村上 弘城, 横山 裕之, 望月 能成, 谷口 健次, 末永 裕之

    日本臨床外科学会雑誌   Vol. 76 ( 10 ) page: 2608 - 2608   2015.10

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  35. 再発癌の治療方針(食道、胃) 進行再発胃癌に対する2次治療における薬剤選択 key drug継続は必要か?

    小林 大介, 中西 香企, 望月 能成, 石榑 清, 伊藤 誠二, 小島 宏, 石山 聡治, 藤竹 信一, 鹿野 敏雄, 小寺 泰弘

    日本臨床外科学会雑誌   Vol. 76 ( 増刊 ) page: 412 - 412   2015.10

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  36. 妊娠29週に発症したS状結腸間膜内ヘルニアの1例

    平田 伸也, 横山 裕之, 大津 智尚, 中西 香企, 森 憲彦, 谷口 健次

    日本腹部救急医学会雑誌   Vol. 35 ( 6 ) page: 781 - 784   2015.9

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    症例は35歳女性。妊娠29週に腹痛,嘔吐を主訴に近医を受診し,イレウスの疑いで当院へ搬送となった。1回の経妊経産歴があり開腹歴はなかった。腹部単純CTで臍左側背側の小腸に閉塞機転を疑う所見を認め,小腸イレウスの診断で入院となった。第3病日になってもイレウス所見の改善がないため,緊急手術となった。まず帝王切開を施行した後に,腹腔内を観察するとS状結腸間膜左葉に2cm大の小孔を認め,Treitz靱帯から290cmの小腸が嵌頓しており,S状結腸間膜内ヘルニアによるイレウスと診断した。用手的に整復することができ,Richter型の嵌頓で腸管壊死は認めなかったため,イレウス解除術で終了し,術後6日目に軽快退院となった。児は生後5ヵ月明らかな障害はなく生存中である。妊娠時イレウスは母児ともに死亡率の高い疾患であり,積極的な検査と手術のタイミングを逸しないことが母児の救命に直結すると考えられる。(著者抄録)

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J02824&link_issn=&doc_id=20151026400016&doc_link_id=10.11231%2Fjaem.35.781&url=https%3A%2F%2Fdoi.org%2F10.11231%2Fjaem.35.781&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  37. 胃 高齢者胃がんの治療ストラテジー S-1既治療胃癌に対する2次治療 Paclitaxel単剤またはS-1+Paclitaxel併用の比較

    小林 大介, 中西 香企, 望月 能成, 石榑 清, 伊藤 誠二, 小島 宏, 石山 聡治, 藤竹 信一, 鹿野 敏雄, 森田 智視, 坂本 純一, 小寺 泰弘

    日本癌治療学会誌   Vol. 50 ( 3 ) page: 1368 - 1368   2015.9

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  38. 上部消化管穿孔症例に対する保存的治療の臨床学的検討

    笹原 正寛, 望月 能成, 中西 香企, 森 憲彦, 佐藤 雄介, 村上 弘城, 神崎 章之, 横山 裕之, 谷口 健次

    日本消化器外科学会総会   Vol. 70回   page: P - 6   2015.7

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  39. 2nd line化学療法をどうするか 諸臨床試験の結果をふまえて S-1既治療2nd line PTX単剤療法またはS-1+PTX併用療法の多施設共同ランダム化比較臨床第II相試験(CCOG0701)

    中西 香企, 小林 大介, 望月 能成, 石榑 清, 伊藤 誠二, 小島 宏, 石山 聡治, 藤竹 信一, 小寺 泰弘

    日本胃癌学会総会記事   Vol. 87回   page: 196 - 196   2015.3

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  40. S‐1既治療2nd line PTX単剤療法またはS‐1+PTX併用療法の多施設共同ランダム化比較臨床第II相試験(CCOG0701)

    中西香企, 小林大介, 望月能成, 石榑清, 伊藤誠二, 小島宏, 石山聡治, 藤竹信一, 小寺泰弘

    日本胃癌学会総会記事   Vol. 87th   page: 196   2015

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KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. KLRG2を介した胃癌肝転移の分子病態解明とバイオマーカー開発

    Grant number:21K16397  2021.4 - 2023.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    中西 香企