Updated on 2025/10/22

写真a

 
OGURA Aya
 
Organization
Brain and Mind Research Center Division Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor
External link

Degree 1

  1. 博士（医学） （ 2020.2   名古屋大学 ） 

To the head of Degree.▲
 

Papers 46

  1. Trajectories of Pontine Volume in Patients with Multiple System Atrophy. Reviewed Open Access

    Kawabata K, Krismer F, Ito M, Hara K, Bagarinao E, Beliveau V, Péran P, Arribarat G, Traon AP, Meissner WG, Foubert-Samier A, Fabbri M, Gordon MF, Ogura A, Katsuno M, Rascol O, Scherfler C, Seppi K, Watanabe H, Poewe W

    Movement disorders : official journal of the Movement Disorder Society   Vol. 40 ( 7 ) page： 1369 - 1378   2025.7

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  2. Combined quantitative analysis of the nigro-striata system in multiple system atrophy and Parkinson's disease. Reviewed

    Hatanaka M, Hara K, Ohba C, Suzuki M, Ogura A, Kawabata K, Ito Y, Tada T, Fujita N, Mori D, Maesawa S, Kato K, Katsuno M

    Journal of the neurological sciences   Vol. 468   page： 123331   2025.1

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  3. ＜Editors' Choice＞ Pattern of THK 5351 retention in normal aging involves core regions of resting state networks associated with higher cognitive function. Reviewed Open Access

    Yoshida Y, Yokoi T, Hara K, Watanabe H, Yamaguchi H, Bagarinao E, Masuda M, Kato T, Ogura A, Ohdake R, Kawabata K, Katsuno M, Kato K, Naganawa S, Okamura N, Yanai K, Sobue G

    Nagoya journal of medical science   Vol. 85 ( 4 ) page： 758 - 771   2023.11

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  4. Comparative examination of the pons and corpus callosum as reference regions for quantitative evaluation in positron emission tomography imaging for Alzheimer's disease using (11)C-Pittsburgh Compound-B. Reviewed Open Access

    Tada T, Hara K, Fujita N, Ito Y, Yamaguchi H, Ohdake R, Kawabata K, Ogura A, Kato T, Yokoi T, Masuda M, Abe S, Miyao S, Naganawa S, Katsuno M, Watanabe H, Sobue G, Kato K

    Annals of nuclear medicine   Vol. 37 ( 7 ) page： 410 - 418   2023.7

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  5. Convenient Auditory-Based Language and Executive Function Test for Patients With Amyotrophic Lateral Sclerosis: A Pilot Study. Reviewed

    Ohdake R, Watanabe H, Kawabata K, Ogura A, Sato M, Tanaka Y, Imai K, Masuda M, Kato T, Yokoi T, Hara K, Nakamura R, Atsuta N, Nakagawa M, Katsuno M, Sobue G

    Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists   Vol. 38 ( 1 ) page： 57 - 71   2023.1

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  6. <SUP>99m</SUP>Tc-ECD SPECTで示唆されたRCVSにおける脳組織障害の遷延 Open Access

    邦武 克彦, 小倉 礼, 古川 宗磨, 伊藤 泰広

    日本頭痛学会誌   Vol. 49 ( 3 ) page： 573 - 577   2023

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    Language：Japanese   Publisher：一般社団法人 日本頭痛学会  

    DOI： 10.50860/jjho.49.3_573

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    CiNii Research

  7. RCVSとPACNS (中枢神経系原発性血管炎)―頭痛を含めた臨床像と診断・治療上の課題― Open Access

    伊藤 泰広, 小野村 仁美, 小倉 礼, 守吉 秀行, 古川 宗磨, 邦武 克彦, 西田 卓, 中井 紀嘉, 鈴木 淳一郎, 吉田 眞理

    日本頭痛学会誌   Vol. 49 ( 3 ) page： 564 - 572   2023

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    Language：Japanese   Publisher：一般社団法人 日本頭痛学会  

    DOI： 10.50860/jjho.49.3_564

    Open Access

    CiNii Research

  8. Persistent brain damage in reversible cerebral vasoconstriction syndrome on (99m)Tc-ethyl cysteinate dimer single-photon emission computed tomography: A long-term observational study. Reviewed

    Kunitake K, Ogura A, Iwata-Hatanaka M, Inagaki R, Furukawa S, Suzuki J, Nakai N, Nishida S, Katsuno M, Ito Y

    Journal of the neurological sciences   Vol. 442   page： 120441   2022.11

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  9. 加齢における認知機能維持と脳の構造的機能的変化の特徴

    小倉礼、バガリナオ・エピファニオ、勝野雅央、祖父江元

    老年精神医学雑誌   Vol. 33 ( 10 ) page： 1079 - 1088   2022.10

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    Authorship：Lead author   Language：Japanese  

  10. Functional connector hubs in the cerebellum. Reviewed Open Access

    Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    NeuroImage   Vol. 257   page： 119263   2022.8

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  11. Fiber-specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis. Reviewed

    Ogura A, Kawabata K, Watanabe H, Choy SW, Bagarinao E, Kato T, Imai K, Masuda M, Ohdake R, Hara K, Nakamura R, Atsuta N, Nakamura T, Katsuno M, Sobue G

    European journal of neurology   Vol. 29 ( 2 ) page： 432 - 440   2022.2

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    Authorship：Lead author   Language：English   Publisher：European Journal of Neurology  

    Background and purpose: To clarify the relationship between fiber-specific white matter changes in amyotrophic lateral sclerosis (ALS) and clinical signs of upper motor neuron (UMN) involvement, we performed a fixel-based analysis (FBA), a novel framework for diffusion-weighted imaging analysis. Methods: We enrolled 96 participants, including 48 nonfamilial ALS patients and 48 age- and sex-matched healthy controls (HCs), in this study and conducted whole-brain FBA and voxel-based morphometry analysis. We compared the fiber density (FD), fiber morphology (fiber cross-section [FC]), and a combined index of FD and FC (FDC) between the ALS and HC groups. We performed a tract-of-interest analysis to extract FD values across the significant regions in the whole-brain analysis. Then, we evaluated the associations between FD values and clinical variables. Results: The bilateral corticospinal tracts (CSTs) and the corpus callosum (CC) showed reduced FD and FDC in ALS patients compared with HCs (p < 0.05, familywise error-corrected), and the comparison of FCs revealed no region that was significantly different from another. Voxel-based morphometry showed cortical volume reduction in the regions, including the primary motor area. Clinical scores showed correlations with FD values in the CSTs (UMN score: rho = −0.530, p < 0.001; central motor conduction time [CMCT] in the upper limb: rho = −0.474, p = 0.008; disease duration: rho = −0.383, p = 0.007; ALS Functional Rating Scale-Revised: rho = 0.340, p = 0.018). In addition, patients whose CMCT was not calculated due to unevoked waves also showed FD reduction in the CSTs. Conclusions: Our findings suggest that FD values in the CST estimated via FBA can be potentially used in evaluating UMN impairments.

    DOI： 10.1111/ene.15136

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  12. Reserve and Maintenance in the Aging Brain: A Longitudinal Study of Healthy Older Adults. Reviewed Open Access

    Bagarinao E, Watanabe H, Maesawa S, Kawabata K, Hara K, Ohdake R, Ogura A, Mori D, Yoneyama N, Imai K, Yokoi T, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    eNeuro   Vol. 9 ( 1 )   2022.1

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  13. Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson's disease. Reviewed Open Access

    Bagarinao E, Kawabata K, Watanabe H, Hara K, Ohdake R, Ogura A, Masuda M, Kato T, Maesawa S, Katsuno M, Sobue G

    Brain communications   Vol. 4 ( 5 ) page： fcac214   2022

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  14. Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus. Reviewed Open Access

    Kawabata K, Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    iScience   Vol. 24 ( 10 ) page： 103106   2021.10

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  15. Individual voxel-based morphometry adjusting covariates in multiple system atrophy. Reviewed

    Ebina J, Hara K, Watanabe H, Kawabata K, Yamashita F, Kawaguchi A, Yoshida Y, Kato T, Ogura A, Masuda M, Ohdake R, Mori D, Maesawa S, Katsuno M, Kano O, Sobue G

    Parkinsonism & related disorders   Vol. 90   page： 114 - 119   2021.9

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    Language：English   Publisher：Parkinsonism and Related Disorders  

    Introduction: This study aimed to evaluate whether novel individual voxel-based morphometry adjusting covariates (iVAC), such as age, sex, and total intracranial volume, could increase the accuracy of a diagnosis of multiple system atrophy (MSA) and enable the differentiation of MSA from Parkinson's disease (PD). Methods: We included 53 MSA patients (MSA-C: 33, MSA-P: 20), 53 PD patients, and 189 healthy controls in this study. All participants underwent high-resolution T1-weighted imaging (WI) and T2-WI with a 3.0-T MRI scanner. We evaluated the occurrence of significant atrophic findings in the pons/middle cerebellar peduncle (MCP) and putamen on iVAC and compared these findings with characteristic changes on T2-WI. Results: On iVAC, abnormal findings were observed in the pons/MCP of 96.2% of MSA patients and in the putamen of 80% of MSA patients; however, on T2-WI, they were both observed at a frequency of 60.4% in MSA patients. On iVAC, all but one MSA-P patient (98.1%) showed significant atrophic changes in the pons/MCP or putamen. By contrast, 69.8% of patients with MSA showed abnormal signal changes in the pons/MCP or putamen on T2-WI. iVAC yielded 95.0% sensitivity and 96.2% specificity for differentiating MSA-P from PD. Conclusion: iVAC enabled us to recognize the morphological characteristics of MSA visually and with high accuracy compared to T2-WI, indicating that iVAC is a potential diagnostic screening tool for MSA.

    DOI： 10.1016/j.parkreldis.2021.07.025

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  16. Clinicoradiological features in amyotrophic lateral sclerosis patients with olfactory dysfunction. Reviewed

    Masuda M, Watanabe H, Ogura A, Ohdake R, Kato T, Kawabata K, Hara K, Nakamura R, Atsuta N, Epifanio B, Katsuno M, Sobue G

    Amyotrophic lateral sclerosis & frontotemporal degeneration   Vol. 22 ( 3-4 ) page： 260 - 266   2021.5

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    Language：English   Publisher：Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration  

    Objective: Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder characterized by motor neuron involvement. Although olfactory dysfunction has been described in ALS, clinicoradiological features associated with the olfactory dysfunction remain poorly understood. Methods: We enrolled 30 patients with ALS and age- and sex-matched 53 healthy controls (HCs). All participants underwent the odor stick identification test for Japanese (OSIT-J) and clinical assessments, including disease duration, ALSFRS-R, site of onset, forced vital capacity, and cognitive examinations that reflected the general, executive, memory and language function. We investigated the associations between OSIT-J score and clinical features and examined atrophic changes by voxel-based morphometry (VBM) analysis to MRI. Results: The OSIT-J score was significantly lower in ALS patients than HCs (6.9 ± 3.2 vs. 9.8 ± 1.9, p < 0.001). In ALS, there were significant relationships between OSIT-J score and age at examination, frontal assessment battery, word fluencies, digit span forward, and ADAS-Jcog recognition, but not education, disease type, duration, ALSFRS-R and, %VC. Multiple regression analysis with stepwise method showed the only ADAS-Jcog recognition substantially predicted OSIT-J score. VBM analysis with age, sex, total intracranial volume, and ADAS-Jcog recognition as covariates showed OSIT-J scores were substantially correlated with atrophic changes of left orbital cortex consisting of gyrus rectus and medial orbital gyrus and right hippocampus in ALS. Conclusion: ALS patients could show substantial olfactory dysfunction in association with orbital cortex and hippocampus involvements. The olfactory examination could be a useful marker for screening of frontotemporal alteration in ALS.

    DOI： 10.1080/21678421.2020.1859544

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  17. Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging. Reviewed Open Access

    Maesawa S, Mizuno S, Bagarinao E, Watanabe H, Kawabata K, Hara K, Ohdake R, Ogura A, Mori D, Nakatsubo D, Isoda H, Hoshiyama M, Katsuno M, Saito R, Ozaki N, Sobue G

    Frontiers in human neuroscience   Vol. 15   page： 753836   2021

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    Language：English   Publisher：Frontiers in Human Neuroscience  

    Purpose: Maintenance of cognitive performance is important for healthy aging. This study aims to elucidate the relationship between brain networks and cognitive function in subjects maintaining relatively good cognitive performance. Methods: A total of 120 subjects, with equal number of participants from each age group between 20 and 70 years, were included in this study. Only participants with Addenbrooke’s Cognitive Examination – Revised (ACE-R) total score greater than 83 were included. Anatomical T1-weighted MR images and resting-state functional MR images (rsfMRIs) were taken from all participants using a 3-tesla MRI scanner. After preprocessing, several factors associated with age including the ACE-R total score, scores of five domains, sub-scores of ACE-R, and brain volumes were tested. Morphometric changes associated with age were analyzed using voxel based morphometry (VBM) and changes in resting state networks (RSNs) were examined using dual regression analysis. Results: Significant negative correlations with age were seen in the total gray matter volume (GMV, r = −0.58), and in the memory, attention, and visuospatial domains. Among the different sub-scores, the score of the delayed recall (DR) showed the highest negative correlation with age (r = −0.55, p < 0.001). In VBM analysis, widespread regions demonstrated negative correlation with age, but none with any of the cognitive scores. Quadratic approximations of cognitive scores as functions of age showed relatively delayed decline compared to total GMV loss. In dual regression analysis, some cognitive networks, including the dorsal default mode network, the lateral dorsal attention network, the right / left executive control network, the posterior salience network, and the language network, did not demonstrate negative correlation with age. Some regions in the sensorimotor networks showed positive correlation with the DR, memory, and fluency scores. Conclusion: Some domains of the cognitive test did not correlate with age, and even the highly correlated sub-scores such as the DR score, showed delayed decline compared to the loss of total GMV. Some RSNs, especially involving cognitive control regions, were relatively maintained with age. Furthermore, the scores of memory, fluency, and the DR were correlated with the within-network functional connectivity values of the sensorimotor network, which supported the importance of exercise for maintenance of cognition.

    DOI： 10.3389/fnhum.2021.753836

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  18. Characteristics of Neural Network Changes in Normal Aging and Early Dementia. Reviewed Open Access

    Watanabe H, Bagarinao E, Maesawa S, Hara K, Kawabata K, Ogura A, Ohdake R, Shima S, Mizutani Y, Ueda A, Ito M, Katsuno M, Sobue G

    Frontiers in aging neuroscience   Vol. 13   page： 747359   2021

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  19. Case Report: Severe Osteoporosis and Preventive Therapy in RNA Polymerase III-Related Leukodystrophy. Reviewed Open Access

    Furukawa S, Kunii M, Doi H, Kondo N, Ogura A, Hirabuki K, Itoh T, Matsumoto N, Tanaka F, Katsuno M, Ito Y

    Frontiers in neurology   Vol. 12   page： 622355   2021

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  20. Identifying the brain's connector hubs at the voxel level using functional connectivity overlap ratio. Reviewed Open Access

    Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Ohdake R, Masuda M, Ogura A, Kato T, Koyama S, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    NeuroImage   Vol. 222   page： 117241   2020.11

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  21. Cerebello-basal ganglia connectivity fingerprints related to motor/cognitive performance in Parkinson's disease. Reviewed

    Kawabata K, Watanabe H, Bagarinao E, Ohdake R, Hara K, Ogura A, Masuda M, Kato T, Tsuboi T, Maesawa S, Katsuno M, Sobue G

    Parkinsonism & related disorders   Vol. 80   page： 21 - 27   2020.11

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  22. The neural network basis of altered decision-making in patients with amyotrophic lateral sclerosis. Reviewed Open Access

    Imai K, Masuda M, Watanabe H, Ogura A, Ohdake R, Tanaka Y, Kato T, Kawabata K, Riku Y, Hara K, Nakamura R, Atsuta N, Bagarinao E, Katahira K, Ohira H, Katsuno M, Sobue G

    Annals of clinical and translational neurology   Vol. 7 ( 11 ) page： 2115 - 2126   2020.11

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  23. Individual changes in visual performance in non-demented Parkinson's disease patients: a 1-year follow-up study. Reviewed

    Ohdake R, Kawabata K, Watanabe H, Hara K, Ogura A, Kato T, Masuda M, Katsuno M, Sobue G

    Journal of neural transmission (Vienna, Austria : 1996)   Vol. 127 ( 10 ) page： 1387 - 1397   2020.10

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  24. Changes in white matter fiber density and morphology across the adult lifespan: A cross-sectional fixel-based analysis. Reviewed Open Access

    Choy SW, Bagarinao E, Watanabe H, Ho ETW, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    Human brain mapping   Vol. 41 ( 12 ) page： 3198 - 3211   2020.8

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    Language：English  

    DOI： 10.1002/hbm.25008

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    PubMed

  25. Analysis of 13 Cases of adult PCNSV Reviewed

    Onomura, H; Kunitake, K; Inagaki, R; Furukawa, S; Moriyoshi, H; Ogura, A; Nishida, S; Ito, Y

    EUROPEAN JOURNAL OF NEUROLOGY   Vol. 27   page： 274 - 274   2020.5

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  26. Aging Impacts the Overall Connectivity Strength of Regions Critical for Information Transfer Among Brain Networks. Reviewed Open Access

    Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Hoshiyama M, Isoda H, Naganawa S, Ozaki N, Sobue G

    Frontiers in aging neuroscience   Vol. 12   page： 592469   2020

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  27. Visuoperceptual disturbances in Parkinson's disease. Reviewed Open Access

    Kawabata K, Ohdake R, Watanabe H, Bagarinao E, Hara K, Ogura A, Masuda M, Kato T, Yokoi T, Katsuno M, Sobue G

    Clinical parkinsonism & related disorders   Vol. 3   page： 100036   2020

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  28. Detection of paroxysmal atrial fibrillation in patient with embolic stroke by active self-management education: a case report Reviewed

    Fukuoka Yasuko, Ogura Aya, Ito Yasuhiro, Mae Chitose, Tomita Kayoko, Omori Toyonori, Kimura Kazumi, Matsumoto Masayasu, Moriyama Michiko

    Japanese Journal of Stroke   Vol. 42 ( 5 ) page： 406 - 412   2020

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    Language：Japanese   Publisher：The Japan Stroke Society  

    <p>The patient is a 65-year-old man was admitted due to the visual disturbance. Neurologic images including cranial CT and MRI showed a cerebral infarction in the right occipital lobe. This infarction was diagnosed as the embolic infarct, but embolic cause including the paroxysmal atrial fibrillation was not detected in further examinations during the hospital stay. He was diagnosed as embolic stroke of undetermined source, however, he was strongly suspected to have undetected paroxysmal atrial fibrillation. He participated in a disease management program for the ischemic stroke recurrence prevention and received self-management educations lead by the disease management nurse. He was educated to measure and record the pulse and blood pressure for himself every day to detect the arrhythmia, especially paroxysmal atrial fibrillation. On the 86th day after the onset, the patient himself noticed the abnormality of blood pressure and irregular pulse in daily check at home and called the disease management nurse. The disease management nurse suspected paroxysmal atrial fibrillation, and suggested him to have a medical examination immediately. As a result, atrial fibrillation was confirmed with an electrocardiogram, and an anticoagulant therapy was started soon after. For the detection of paroxysmal atrial fibrillation in embolic stroke of undetermined source, the self-management education to the patients was proved to be effective.</p>

    DOI： 10.3995/jstroke.10741

    CiNii Research

  29. Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement. Reviewed Open Access

    Ogura A, Watanabe H, Kawabata K, Ohdake R, Tanaka Y, Masuda M, Kato T, Imai K, Yokoi T, Hara K, Bagarinao E, Riku Y, Nakamura R, Kawai Y, Nakatochi M, Atsuta N, Katsuno M, Sobue G

    EBioMedicine   Vol. 47   page： 506 - 517   2019.9

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    Authorship：Lead author   Language：English  

    DOI： 10.1016/j.ebiom.2019.08.022

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  30. Reorganization of brain networks and its association with general cognitive performance over the adult lifespan. Reviewed Open Access

    Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Taoka T, Koyama S, Tanabe HC, Katsuno M, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G

    Scientific reports   Vol. 9 ( 1 ) page： 11352   2019.8

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  31. Alterations in Cognition-Related Cerebello-Cerebral Networks in Multiple System Atrophy. Reviewed

    Kawabata K, Hara K, Watanabe H, Bagarinao E, Ogura A, Masuda M, Yokoi T, Kato T, Ohdake R, Ito M, Katsuno M, Sobue G

    Cerebellum (London, England)   Vol. 18 ( 4 ) page： 770 - 780   2019.8

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  32. Five cases of cerebral amyloid angiopathy related inflammation/angiitis diagnosed with brain biopsy. Reviewed

    Moriyoshi, H; Furukawa, S; Ogura, A; Ito, Y; Yoshida, M; Katsuno, M

    BRAIN PATHOLOGY   Vol. 29   page： 15 - 16   2019.2

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  33. Age-related impairment in Addenbrooke's cognitive examination revised scores in patients with amyotrophic lateral sclerosis. Reviewed

    Masuda M, Watanabe H, Tanaka Y, Ohdake R, Ogura A, Yokoi T, Imai K, Kawabata K, Riku Y, Hara K, Nakamura R, Atsuta N, Katsuno M, Sobue G

    Amyotrophic lateral sclerosis & frontotemporal degeneration   Vol. 19 ( 7-8 ) page： 578 - 584   2018.11

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  34. Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy. Reviewed

    Hara K, Watanabe H, Bagarinao E, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Tsuboi T, Ito M, Atsuta N, Niwa H, Taoka T, Maesawa S, Naganawa S, Katsuno M, Sobue G

    Journal of neurology   Vol. 265 ( 9 ) page： 2079 - 2087   2018.9

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  35. An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan.

    Bagarinao E, Watanabe H, Maesawa S, Mori D, Hara K, Kawabata K, Yoneyama N, Ohdake R, Imai K, Masuda M, Yokoi T, Ogura A, Wakabayashi T, Kuzuya M, Ozaki N, Hoshiyama M, Isoda H, Naganawa S, Sobue G

    NeuroImage   Vol. 169   page： 134 - 144   2018.4

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  36. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease.

    Kawabata K, Watanabe H, Hara K, Bagarinao E, Yoneyama N, Ogura A, Imai K, Masuda M, Yokoi T, Ohdake R, Tanaka Y, Tsuboi T, Nakamura T, Hirayama M, Ito M, Atsuta N, Maesawa S, Naganawa S, Katsuno M, Sobue G

    Journal of neurology   Vol. 265 ( 3 ) page： 688 - 700   2018.3

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  37. Involvement of the Precuneus/Posterior Cingulate Cortex Is Significant for the Development of Alzheimer's Disease: A PET (THK5351, PiB) and Resting fMRI Study. Reviewed Open Access

    Yokoi T, Watanabe H, Yamaguchi H, Bagarinao E, Masuda M, Imai K, Ogura A, Ohdake R, Kawabata K, Hara K, Riku Y, Ishigaki S, Katsuno M, Miyao S, Kato K, Naganawa S, Harada R, Okamura N, Yanai K, Yoshida M, Sobue G

    Frontiers in aging neuroscience   Vol. 10   page： 304   2018

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  38. Cerebral hypoperfusion in reversible cerebral vasoconstriction syndrome(RCVS): Single photon emission computed tomography (SPECT) analysis with an easy Z-score imaging system (eZIS)

    Iwata, M; Ogura, A; Inagaki, R; Furukawa, S; Suzuki, J; Nishida, S; Ito, Y

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page： 431 - 431   2017.10

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  39. The retention pattern of THK5351 pet imaging and functional network disruption associated with development of Alzheimer's disease

    Yokoi, T; Watanabe, H; Yamaguchi, H; Bagarinao, E; Masuda, M; Imai, K; Ogura, A; Ohdake, R; Kawabata, K; Hara, K; Riku, Y; Ishigaki, S; Katsuno, M; Kato, K; Naganawa, S; Okamura, N; Miyao, S; Yanai, K; Sobue, G

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page： 960 - 961   2017.10

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  40. Investigation of 9 adult PCNSV(primary central nervous system vasculitis) patients

    Furukawa, S; Kunitake, K; Inagaki, R; Iwata, M; Moriyoshi, H; Ogura, A; Suzuki, J; Nakai, N; Nishida, S; Ito, Y

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page： 288 - 288   2017.10

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  41. Early cognitive decline pattern is associated with distinct resting-state networks disruption in non-demented Parkinson's disease patients

    Kawabata, K; Watanabe, H; Hara, K; Bagarinao, E; Yoneyama, N; Ogura, A; Imai, K; Masuda, M; Yokoi, T; Ohdake, R; Tsuboi, T; Ito, M; Atsuta, N; Katsuno, M; Sobue, G

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page： 128 - 128   2017.10

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  42. Decision making alteration and characteristic connectivity changes in amyotrophic lateral sclerosis

    Imai, K; Masuda, M; Watanabe, H; Kamagata, K; Katahira, K; Ogura, A; Ohdake, R; Kawabata, K; Yokoi, T; Hara, K; Bagarinao, E; Atsuta, N; Nakamura, R; Aoki, S; Katsuno, M; Ohira, H; Sobue, G

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page： 103 - 103   2017.10

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  43. Clinical and radiologic characteristics of recent Japanese patients with pellagra encephalopathy

    Inagaki, R; Kunitake, K; Furukawa, S; Iwata, M; Moriyoshi, H; Ogura, A; Suzuki, J; Nakai, N; Nishida, S; Yoshida, M; Ito, Y

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page： 697 - 698   2017.10

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  44. Characteristics of semantic impairment in ALS associated with <i>jukujikun</i>

    Ogura, A; Masuda, M; Imai, K; Ohdake, R; Tanaka, Y; Yokoi, T; Kawabata, K; Hara, K; Nakamura, R; Atsuta, N; Watanabe, H; Katsuno, M; Sobue, G

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page： 571 - 571   2017.10

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  45. Characteristics of cognitive features in ALS using the addenbrooke's cognitive examination revised (ACE-R)

    Masuda, M; Imai, K; Ohdake, R; Tanaka, Y; Ogura, A; Yokoi, T; Kawabata, K; Hara, K; Nakamura, R; Atsuta, N; Watanabe, H; Katsuno, M; Sobue, G

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page： 564 - 564   2017.10

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  46. Development of electrical medical record template for evaluating and selecting a suitable non-vitamin-K antagonist oral anticoagulant (NOAC) Reviewed

    Ogura Aya, Nakai Noriyoshi, Imai Keiko, Iwata Mai, Moriyoshi Hideyuki, Suzuki Junichiro, Nishida Suguru, Naito Hideo, Yasuda Takeshi, Ito Yasuhiro

    Japanese Journal of Stroke   Vol. 39 ( 1 ) page： 38 - 41   2017

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    Authorship：Lead author   Language：Japanese   Publisher：The Japan Stroke Society  

    Recently four NOACs have become available, which requires us to determine the most appropriate one among the options. Since each NOAC has a specific indication and two different dosages according to various patient criteria including age, weight, renal function, and so on, it is often confusing and troublesome to compare them and select the best one. We developed an electrical medical record template for automatically evaluating and selecting the most suitable candidate among four NOAC candidates. In selecting an adequate NOAC, this system is easy and useful for objective comparison and apparent assessment, avoiding contraindication and off-label use.

    DOI： 10.3995/jstroke.10385

    CiNii Research

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Presentations 1

  1. Spread of network connectivity beginning in the preclinical stages of Alzheimer's disease.

    Aya OGURA

    2025.5.21 

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    Event date： 2025.5

    Language：English   Presentation type：Poster presentation  

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. Clinical phenotype of multiple system atrophy by imaging

    Grant number：24K10638  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Coinvestigator(s) 

  2. アルツハイマー型認知症プレクリニカル期における神経回路の加齢性変化の解明

    Grant number：24K18682  2024.4 - 2026.3

    科学研究費助成事業  若手研究

    小倉 礼

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    Authorship：Principal investigator 

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

    認知症の原因疾患として最多を占めるアルツハイマー型認知症では、発症の20～30年前より脳内に病理学的変化が出現し始めると言われている。アルツハイマー型認知症の発症に関わる異常蛋白を除去し病気の根本部分にアプローチする治療法が研究され一部実用化されている。疾患修飾薬と呼ばれるこのような治療法は病気が高度に進展する前の段階で使用することが重要である。本研究では、MRI画像を用いてアルツハイマー型認知症の病前状態にある脳の構造的機能的変化を捉え、代償的ネットワークとその破綻という観点からアルツハイマー型認知症の病前状態の神経基盤の解明を目指す研究である。

  3. Integrated analysis of brain networks and blood biomarkers related to cognitive reserve

    Grant number：22K15728  2022.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Ogura Aya

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    Authorship：Principal investigator 

    Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）

    Blood biomarkers of Alzheimer's disease, including amyloid-β (Aβ), were measured in healthy elderly subjects, and imaging features related to maintenance of cognitive function were evaluated.
    In the imaging analysis, we compared the resting-state functional network changes between the group with normal cognitive function and negative Aβ (NC group) and the group with normal cognitive function but positive Aβ (CR group). It showed increased connectivity between the posterior cingulate gyrus and regions included in the salience network in the CR group. The network changes correlated with blood biomarkers of Aβ showed a similar trend. On the other hand, the network changes correlated with p-tau181 showed mainly decreased connectivity.

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Teaching Experience (On-campus) 5

  1. 脳神経内科の重点疾患を学ぼう –脳卒中＆認知症–

    2025

  2. 認知症の今とこれから －最新研究と治療への展望－

    2024

    　詳細を見る

    認知症の病態機序、診断、治療

  3. 認知症の今とこれから －最新研究と治療への展望－

    2023

    　詳細を見る

    認知症の病態機序、診断、治療

  4. 生涯健康と医学

    2022

    　詳細を見る

    認知機能とその障害、認知症について

  5. 認知症の今とこれから

    2022

    　詳細を見る

    認知症の病態機序、診断、治療

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Social Contribution 5

  1. 早期アルツハイマー病の診療体制を考える ～名古屋大学の体制を踏まえて～

    Role(s)：Lecturer

    名古屋市東区医師会  名古屋市東区医師会学術講演会  2025.6

  2. 認知症の臨床診断と検査方法

    Role(s)：Lecturer

    愛知県看護協会  2025年認知症看護 認定看護師教育課程  2025.6

  3. 当院における抗アミロイドβ抗体薬治療の現状

    Role(s)：Lecturer

    PDRファーマ株式会社  アルツハイマー病診療web講演会  2025.4

  4. 認知症の診断と治療 - 新しい治療薬も含めた現在の認知症診療について -

    Role(s)：Lecturer

    イオンモールNagoya Noritake Garden / 名古屋大学脳とこころの研究センター  令和6年度名古屋大学脳とこころの研究センター　市民公開講座  2024.10

  5. アルツハイマー型認知症の診断と治療

    Role(s)：Lecturer

    興和株式会社  社内研修会  2022.10

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