2021/10/29 更新

写真a

ワダ エリ
和田 恵梨
WADA Eri
所属
環境医学研究所 メタボ栄養科学寄附研究部門 特任助教
職名
特任助教

学位 1

  1. 博士(医学) ( 2021年3月   群馬大学 ) 

研究分野 2

  1. ライフサイエンス / 栄養学、健康科学

  2. ライフサイエンス / 代謝、内分泌学

受賞 3

  1. 奨励賞

    2020年11月   日本アミノ酸学会  

  2. ホープ賞

    2020年2月   群馬大学 生体調節研究所  

  3. 若手研究会長賞

    2020年1月   日本病態栄養学会  

 

論文 3

  1. Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice.

    Wada E, Kobayashi M, Kohno D, Kikuchi O, Suga T, Matsui S, Yokota-Hashimoto H, Honzawa N, Ikeuchi Y, Tsuneoka H, Hirano T, Obinata H, Sasaki T, Kitamura T

    The Journal of nutritional biochemistry   97 巻   頁: 108811   2021年11月

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    記述言語:英語  

    DOI: 10.1016/j.jnutbio.2021.108811

    PubMed

  2. Higher estimated net endogenous acid production with lower intake of fruits and vegetables based on a dietary survey is associated with the progression of chronic kidney disease 国際誌

    Toba Koji, Hosojima Michihiro, Kabasawa Hideyuki, Kuwahara Shoji, Murayama Toshiko, Yamamoto-Kabasawa Keiko, Kaseda Ryohei, Wada Eri, Watanabe Reiko, Tanabe Naohito, Suzuki Yoshiki, Narita Ichiei, Saito Akihiko

    BMC NEPHROLOGY   20 巻 ( 1 ) 頁: 421 - 421   2019年11月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC Nephrology  

    Background: Dietary acid load has been suggested to mediate the progression of chronic kidney disease (CKD). However, it is unclear what kinds of foods are actually associated with dietary acid load in patients with CKD. The self-administered diet history questionnaire (DHQ), which semi-quantitatively assesses the dietary habits of Japanese individuals through 150 question items, can estimate average daily intake of various foods and nutrients during the previous month. Using the DHQ, we investigated the association of dietary acid load with CKD progression. We also analyzed the kinds of food that significantly affect dietary acid load. Methods: Subjects were 96 outpatients with CKD (average estimated glomerular filtration rate [eGFR], 53.0 ± 18.1 ml/min/1.73 m2) at Niigata University Hospital, who had completed the DHQ in 2011. We calculated net endogenous acid production (NEAP) from potassium and protein intake evaluated by the DHQ in order to assess dietary acid load. CKD progression was assessed by comparing eGFR between 2008 and 2014. Results: NEAP was not correlated with protein intake (r = 0.088, p = 0.398), but was negatively correlated with potassium intake (r =-0.748, p < 0.001). Reduction in eGFR from 2008 to 2014 was estimated to be significantly greater in patients with higher NEAP (NEAP > 50.1 mEq/day, n = 45) than in those with lower NEAP (NEAP ≤50.1 mEq/day, n = 50) by 5.9 (95% confidence interval [95%CI], 0.1 to 11.6) ml/min/1.73 m2. According to multiple logistic regression analysis, higher NEAP was significantly associated with lower intake of fruits (odds ratio [OR], 6.454; 95%CI, 2.19 to 19.00), green and yellow vegetables (OR, 5.18; 95%CI, 1.83 to14.66), and other vegetables (OR, 3.87; 95%CI, 1.29 to 11.62). Conclusions: Elevated NEAP could be a risk factor for CKD progression. Low intake of fruits and vegetables would increase dietary acid load and might affect the progression of renal dysfunction in Japanese CKD patients.

    DOI: 10.1186/s12882-019-1591-8

    Web of Science

    Scopus

    PubMed

  3. SGLT1 in pancreatic alpha cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels 国際誌

    Suga Takayoshi, Kikuchi Osamu, Kobayashi Masaki, Matsui Sho, Yokota-Hashimoto Hiromi, Wada Eri, Kohno Daisuke, Sasaki Tsutomu, Takeuchi Kazusane, Kakizaki Satoru, Yamada Masanobu, Kitamura Tadahiro

    MOLECULAR METABOLISM   19 巻   頁: 1 - 12   2019年1月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Molecular Metabolism  

    Objectives: It is controversial whether sodium glucose transporter (SGLT) 2 inhibitors increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role of SGLT1 in α cells is also unclear. We aimed to elucidate these points that are important not only for basic research but also for clinical insight. Methods: Plasma glucagon levels were assessed in the high-fat, high-sucrose diet (HFHSD) fed C57BL/6J mice treated with dapagliflozin or canagliflozin. RT-PCR, RNA sequence, and immunohistochemistry were conducted to test the expression of SGLT1 and SGLT2 in α cells. We also used αTC1 cells and mouse islets to investigate the molecular mechanism by which SGLT1 modulates glucagon secretion. Results: Dapagliflozin, but not canagliflozin, increased plasma glucagon levels in HFHSD fed mice. SGLT1 and glucose transporter 1 (GLUT1), but not SGLT2, were expressed in αTC1 cells, mouse islets and human islets. A glucose clamp study revealed that the plasma glucagon increase associated with dapagliflozin could be explained as a response to acute declines in blood glucose. Canagliflozin suppressed glucagon secretion by inhibiting SGLT1 in α cells; consequently, plasma glucagon did not increase with canagliflozin, even though blood glucose declined. SGLT1 effect on glucagon secretion depended on glucose transport, but not glucose metabolism. Islets from HFHSD and db/db mice displayed higher SGLT1 mRNA levels and lower GLUT1 mRNA levels than the islets from control mice. These expression levels were associated with higher glucagon secretion. Furthermore, SGLT1 inhibitor and siRNA against SGLT1 suppressed glucagon secretion in isolated islets. Conclusions: These data suggested that a novel mechanism regulated glucagon secretion through SGLT1 in α cells. This finding possibly explained the distinct effects of dapagliflozin and canagliflozin on plasma glucagon levels in mice.

    DOI: 10.1016/j.molmet.2018.10.009

    Web of Science

    Scopus

    PubMed

MISC 2

  1. 栄養と感覚(嗅覚/味覚を中心とした)の新しい融合研究領域 グルカゴンによるアミノ酸・糖代謝調節と糖尿病・肥満

    北村 忠弘, 和田 恵梨, 小林 雅樹  

    日本栄養・食糧学会大会講演要旨集73回 巻   頁: 156 - 156   2019年4月

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    記述言語:日本語   出版者・発行元:(公社)日本栄養・食糧学会  

  2. グルカゴンは糖代謝よりもアミノ酸代謝に重要? 糖尿病・肥満に対する治療標的の可能性も含めて

    北村 忠弘, 和田 恵梨, 小林 雅樹  

    アミノ酸研究12 巻 ( 2 ) 頁: 81 - 87   2019年3月

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    記述言語:日本語   出版者・発行元:日本アミノ酸学会  

科研費 1

  1. 糖尿病における分岐鎖アミノ酸代謝とグルカゴン分泌の関連の解明

    研究課題/研究課題番号:21K21213  2021年8月 - 2023年3月

    科学研究費助成事業  研究活動スタート支援

    和田 恵梨

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    担当区分:研究代表者 

    配分額:3120000円 ( 直接経費:2400000円 、 間接経費:720000円 )