Updated on 2021/10/29


Research Institute of Environmental Medicine Designated assistant professor
Designated assistant professor

Degree 1

  1. 博士(医学) ( 2021.3   群馬大学 ) 

Research Areas 2

  1. Life Science / Nutrition science and health science

  2. Life Science / Metabolism and endocrinology

Awards 3

  1. JSAAS Award 2020 for Outstanding Young Investigator

    2020.11   Japanese Society for Amino Acid Sciences  

  2. ホープ賞


  3. 若手研究会長賞

    2020.1   Japan Society of Metabolism and Clinical Nutrition  


Papers 3

  1. Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice.

    Wada E, Kobayashi M, Kohno D, Kikuchi O, Suga T, Matsui S, Yokota-Hashimoto H, Honzawa N, Ikeuchi Y, Tsuneoka H, Hirano T, Obinata H, Sasaki T, Kitamura T

    The Journal of nutritional biochemistry   Vol. 97   page: 108811   2021.11

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    DOI: 10.1016/j.jnutbio.2021.108811


  2. Higher estimated net endogenous acid production with lower intake of fruits and vegetables based on a dietary survey is associated with the progression of chronic kidney disease. International journal

    Koji Toba, Michihiro Hosojima, Hideyuki Kabasawa, Shoji Kuwahara, Toshiko Murayama, Keiko Yamamoto-Kabasawa, Ryohei Kaseda, Eri Wada, Reiko Watanabe, Naohito Tanabe, Yoshiki Suzuki, Ichiei Narita, Akihiko Saito

    BMC nephrology   Vol. 20 ( 1 ) page: 421 - 421   2019.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Dietary acid load has been suggested to mediate the progression of chronic kidney disease (CKD). However, it is unclear what kinds of foods are actually associated with dietary acid load in patients with CKD. The self-administered diet history questionnaire (DHQ), which semi-quantitatively assesses the dietary habits of Japanese individuals through 150 question items, can estimate average daily intake of various foods and nutrients during the previous month. Using the DHQ, we investigated the association of dietary acid load with CKD progression. We also analyzed the kinds of food that significantly affect dietary acid load. METHODS: Subjects were 96 outpatients with CKD (average estimated glomerular filtration rate [eGFR], 53.0 ± 18.1 ml/min/1.73 m2) at Niigata University Hospital, who had completed the DHQ in 2011. We calculated net endogenous acid production (NEAP) from potassium and protein intake evaluated by the DHQ in order to assess dietary acid load. CKD progression was assessed by comparing eGFR between 2008 and 2014. RESULTS: NEAP was not correlated with protein intake (r = 0.088, p = 0.398), but was negatively correlated with potassium intake (r = - 0.748, p < 0.001). Reduction in eGFR from 2008 to 2014 was estimated to be significantly greater in patients with higher NEAP (NEAP > 50.1 mEq/day, n = 45) than in those with lower NEAP (NEAP ≤50.1 mEq/day, n = 50) by 5.9 (95% confidence interval [95%CI], 0.1 to 11.6) ml/min/1.73 m2. According to multiple logistic regression analysis, higher NEAP was significantly associated with lower intake of fruits (odds ratio [OR], 6.454; 95%CI, 2.19 to 19.00), green and yellow vegetables (OR, 5.18; 95%CI, 1.83 to14.66), and other vegetables (OR, 3.87; 95%CI, 1.29 to 11.62). CONCLUSIONS: Elevated NEAP could be a risk factor for CKD progression. Low intake of fruits and vegetables would increase dietary acid load and might affect the progression of renal dysfunction in Japanese CKD patients.

    DOI: 10.1186/s12882-019-1591-8

    Web of Science



  3. SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels. International journal

    Takayoshi Suga, Osamu Kikuchi, Masaki Kobayashi, Sho Matsui, Hiromi Yokota-Hashimoto, Eri Wada, Daisuke Kohno, Tsutomu Sasaki, Kazusane Takeuchi, Satoru Kakizaki, Masanobu Yamada, Tadahiro Kitamura

    Molecular metabolism   Vol. 19   page: 1 - 12   2019.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: It is controversial whether sodium glucose transporter (SGLT) 2 inhibitors increase glucagon secretion via direct inhibition of SGLT2 in pancreatic α cells. The role of SGLT1 in α cells is also unclear. We aimed to elucidate these points that are important not only for basic research but also for clinical insight. METHODS: Plasma glucagon levels were assessed in the high-fat, high-sucrose diet (HFHSD) fed C57BL/6J mice treated with dapagliflozin or canagliflozin. RT-PCR, RNA sequence, and immunohistochemistry were conducted to test the expression of SGLT1 and SGLT2 in α cells. We also used αTC1 cells and mouse islets to investigate the molecular mechanism by which SGLT1 modulates glucagon secretion. RESULTS: Dapagliflozin, but not canagliflozin, increased plasma glucagon levels in HFHSD fed mice. SGLT1 and glucose transporter 1 (GLUT1), but not SGLT2, were expressed in αTC1 cells, mouse islets and human islets. A glucose clamp study revealed that the plasma glucagon increase associated with dapagliflozin could be explained as a response to acute declines in blood glucose. Canagliflozin suppressed glucagon secretion by inhibiting SGLT1 in α cells; consequently, plasma glucagon did not increase with canagliflozin, even though blood glucose declined. SGLT1 effect on glucagon secretion depended on glucose transport, but not glucose metabolism. Islets from HFHSD and db/db mice displayed higher SGLT1 mRNA levels and lower GLUT1 mRNA levels than the islets from control mice. These expression levels were associated with higher glucagon secretion. Furthermore, SGLT1 inhibitor and siRNA against SGLT1 suppressed glucagon secretion in isolated islets. CONCLUSIONS: These data suggested that a novel mechanism regulated glucagon secretion through SGLT1 in α cells. This finding possibly explained the distinct effects of dapagliflozin and canagliflozin on plasma glucagon levels in mice.

    DOI: 10.1016/j.molmet.2018.10.009

    Web of Science




  1. 栄養と感覚(嗅覚/味覚を中心とした)の新しい融合研究領域 グルカゴンによるアミノ酸・糖代謝調節と糖尿病・肥満

    北村 忠弘, 和田 恵梨, 小林 雅樹

    日本栄養・食糧学会大会講演要旨集   Vol. 73回   page: 156 - 156   2019.4

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    Language:Japanese   Publisher:(公社)日本栄養・食糧学会  

  2. グルカゴンは糖代謝よりもアミノ酸代謝に重要? 糖尿病・肥満に対する治療標的の可能性も含めて

    北村 忠弘, 和田 恵梨, 小林 雅樹

    アミノ酸研究   Vol. 12 ( 2 ) page: 81 - 87   2019.3

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    Language:Japanese   Publisher:日本アミノ酸学会  

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. 糖尿病における分岐鎖アミノ酸代謝とグルカゴン分泌の関連の解明

    Grant number:21K21213  2021.8 - 2023.3

    科学研究費助成事業  研究活動スタート支援

    和田 恵梨

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    Authorship:Principal investigator 

    Grant amount:\3120000 ( Direct Cost: \2400000 、 Indirect Cost:\720000 )