Updated on 2023/09/30

写真a

 
ITO Kumiko
 
Organization
Graduate School of Science Designated assistant professor
Title
Designated assistant professor
External link

Degree 1

  1. Doctor of Science ( 2006.6   Nagoya University ) 

Research Interests 3

  1. astrobiology

  2. cyanobacteria

  3. circadian clock

Research Areas 1

  1. Natural Science / Biogeosciences  / circadian clock mechanism of cyanobacteria

Research History 1

  1. Nagoya University   Graduate School of Science Division of Biological Science   Designated assistant professor

    2021.6

Education 1

  1. Nagoya University   Graduate School of Science   Division of Biological Science

    2003.4 - 2006.3

Professional Memberships 1

  1. 時間生物学会

 

Papers 13

  1. Regulation mechanisms of the dual ATPase in KaiC.

    Furuike Y, Mukaiyama A, Koda SI, Simon D, Ouyang D, Ito-Miwa K, Saito S, Yamashita E, Nishiwaki-Ohkawa T, Terauchi K, Kondo T, Akiyama S

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 119 ( 19 ) page: e2119627119   2022.5

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    Language:English  

    DOI: 10.1073/pnas.2119627119

    PubMed

  2. Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.

    Furuike Y, Mukaiyama A, Ouyang D, Ito-Miwa K, Simon D, Yamashita E, Kondo T, Akiyama S

    Science advances   Vol. 8 ( 15 ) page: eabm8990   2022.4

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    Language:English  

    DOI: 10.1126/sciadv.abm8990

    PubMed

  3. Tuning the circadian period of cyanobacteria up to 6.6 days by the single amino acid substitutions in KaiC. Reviewed

    1. Ito-Miwa K, Furuike Y, Akiyama S and Kondo T.

    Proc. Natl. Acad. Sci. USA,   Vol. 117 ( 34 ) page: 20926 - 20931   2020.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1073/pnas.2005496117

  4. Development and Optimization of Expression, Purification, and ATPase Assay of KaiC for Medium-Throughput Screening of Circadian Clock Mutants in Cyanobacteria. Reviewed

    2. Ouyang D, Furuike Y , Mukaiyama A , Ito-Miwa K, Kondo T and Akiyama S.

    Int. J. Mol. Sci.   Vol. 20 ( 11 ) page: 2789   2019.6

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    Language:English  

  5. シアノバクテリアの概日時計タンパク質KaiC が1日を計る仕組み Invited Reviewed

    13. 伊藤久美子、近藤孝男、

    時間生物学   Vol. 24   page: 23 - 29   2018

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    Authorship:Lead author   Language:Japanese  

  6. シアノバクテリアの概日時計タンパク質KaiC による計時機構 Invited

    15. 伊藤久美子、村中智明、近藤孝男、

    生体の科学   Vol. 67 ( 6 ) page: 1 - 5   2016

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    Authorship:Lead author   Language:Japanese  

  7. Overexpression of a CO homologue disrupts the rhythmic expression of clock gene LgLHYH1 in Lemna gibba. Reviewed

    3. Ito-Miwa K, Serikawa M, Kondo T, Oyama T.

    Plant Biotechnology.   Vol. 31 ( 4 ) page: 319   2014

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  8. Functional conservation of clock-related genes in flowering plants: overexpression and RNA interference analyses of the circadian rhythm in the monocotyledon Lemna gibba. Reviewed

    4. Serikawa M, Miwa K, Kondo T and Oyama T.

    Plant Physiol.   Vol. 146   page: 1952 - 1963   2008

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    Language:English   Publishing type:Research paper (scientific journal)  

  9. ATPase activity of KaiC determines the basic timing for circadian clock of cyanobacteria. Reviewed

    5. Terauchi K, Kitayama Y, Nishiwaki T, Miwa K, Murayama Y, Oyama T and Kondo T,

    Proc. Natl. Acad. Sci. USA,   Vol. 104 ( 41 ) page: 16377 - 16381   2007

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    Language:English   Publishing type:Research paper (scientific journal)  

  10. Identification of amino acid substitutions that render the Arabidopsis cytokinin receptor histidine kinase AHK4 constitutively active Reviewed

    6. Miwa K, Ishikawa K, Terada K, Yamada H, Suzuki T, Yamashino T and Mizuno T.

    Plant Cell Physiol.   Vol. 48 ( 12 ) page: 1809 - 1804   2007

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  11. Conserved expression profiles of circadian clock-related genes in two Lemna species showing long-day and short-day photoperiodic flowering responses. Reviewed

    Miwa K, Serikawa M, Suzuki T, Kondo T and Oyama T.

    Plant Cell Physiol.   Vol. 47 ( 5 ) page: 601 - 612   2006

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  12. The Arabidopsis AHK4 histidine kinase is a cytokinin-binding receptor that transduces cytokinin signals across the membrane. Reviewed

    Yamada H, Suzuki T, Terada K, Takei K, Ishikawa K, Miwa K, Yamashino T and Mizuno T.

    Plant Cell Physiol.   Vol. 42 ( 9 ) page: 1017 - 1023   2001

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    Language:English   Publishing type:Research paper (scientific journal)  

  13. The Arabidopsis sensor His-kinase, AHK4, can respond to cytokinins. Reviewed

    9. Suzuki T, Miwa K, Ishikawa K, Yamada H, Aiba H and Mizuno T.

    Plant Cell Physiol.   Vol. 42 ( 2 ) page: 107 - 113   2001

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

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Books 5

  1. Mechanism of the Cyanobacterial Circadian Clock protein KaiC to measure 24 hours

    2021.6  ( ISBN:9783030721572

  2. v International journal

    Nussaume Laurent, Desnos Thierry, Jinsheng Zhu, David Pascale, Kumiko Miwa, Kanno Satomi( Role: Joint author ,  Analysis and Comparison of Alphafold-Structure Predictions between Pi-Uptake Transporters Recovering Phosphate in Natural Environments )

    Taylor & Francis Group  2023.10 

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    Total pages:171   Language:English

    DOI: https://doi.org/10.1201/9781003440079

  3. 発光イメージング実験ガイド

    14. 伊藤(三輪)久美子、近藤孝男( Role: Joint author ,  発光によるシアノバクテリアのコロニースクリーニング)

    羊土社  2019 

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    Total pages:223   Responsible for pages:168-176   Language:Japanese

  4. Photoperiodism the biological calendar

    16. Ito-Miwa K and Oyama T. ( Role: Joint author ,  Photoperiodic control of flowering in Lemna. )

    Oxford University Press,  2010 

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    Responsible for pages:74-87   Language:English

  5. 光周性の分子生物学

    伊藤久美子、小山時隆( Role: Joint author ,  ウキクサの例にみる植物の光周性反応)

    シュプリンガー・ジャパン株式会社 

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    Responsible for pages:1-14   Language:Japanese

Presentations 4

  1. 時計タンパク質KaiCのATPaseの機能から考える概日時計メ カニズム Invited

    伊藤久美子、近藤孝男

    日本睡眠学会第45回定期学術集会・第30回日本時間生物学会学術大会 合同 大会  2023.9.17 

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    Event date: 2023.9

    Language:Japanese  

    Venue:横浜  

  2. Green underwater world : the coevolution of light-harvesting system of cyanobacteria and underwater light environment Invited

    Kumiko Ito, Taro Matsuo , Yosuke Hoshino, Satomi Kanno, Yuri I. Fujii、Rio Tsuji, Kazuhiro J. Fujimoto, Hideaki Miyashita

    2023.9.1 

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    Event date: 2023.8 - 2023.9

    Language:English  

  3. A View of the Cyanobacterial Circadian Clock Mechanism Based on Atpase Activity Invited International conference

    Kumiko Ito-Miwa

    2022 SRBR Meeting  2022.5 

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    Event date: 2022.5

    Language:English  

  4. Mechanical clock model for cyanobacterial circadian clock, based on the activities of two ATPase domains in KaiC Invited International conference

    Kumiko Ito-Miwa, Takao Kondo

    第59回 日本生物物理学会年 会  2021.11 

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    Event date: 2021.11

    Language:English  

Research Project for Joint Research, Competitive Funding, etc. 2

  1. 時計タンパク質KaiCの2つのATPaseによる機械的な概日時計機構

    2021.11 - 2023.10

    公益財団法人 大隅基礎科学創成財団 第5期(2021年度)研究助成(一般) 

    伊藤久美子

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    Authorship:Principal investigator  Grant type:Competitive

  2. 大酸化イベントを引き起こしたシアノバクテリアの集光戦略についての研究

    2022.4 - 2023.3

    令和4年度アストロバイオロジーセンタープロジェクトプロジェクト研究 

    伊藤久美子、松尾太郎、藤井悠里、菅野里美

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    Authorship:Principal investigator  Grant type:Competitive

    Direct Cost: \2100000 )

KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. Study of the coevolution of light environment on the Earth and the light-harvesting strategies in cyanobacteria

    Grant number:23H01288  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\16640000 ( Direct Cost: \12800000 、 Indirect Cost:\3840000 )

  2. シアノバクテリアの頑健な概日リズムを実現するKaiC複合体の新規翻訳後制御の解析

    Grant number:23K05031  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    岡野 圭子, 三輪久美子

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    Authorship:Coinvestigator(s) 

    シアノバクテリアの概日時計では、3つのKaiタンパク質とATPのみで試験管内でも化学的振動を示し、その振動機構の理解が進んできた。一方、細胞内でこの振動体は様々な環境的外乱に晒されるが、24時間振動を頑健に刻み続ける機構は明らかではない。これまでに細胞内KaiCの複数の機能未知分子との相互作用、さらに新規のKaiCリン酸化部位を同定し、新規翻訳後制御の可能性を見出した。本研究では、KaiC複合体および新たなKaiCリン酸化の時刻変動による翻訳後制御に着目し、変異体による機能解析をin vivoとin vitroで行い、細胞内で時計を安定的に維持する機構を明らかにすることを目的とする。