Updated on 2022/08/29

写真a

 
KIM Jeonghyun
 
Organization
Graduate School of Engineering Mechanical Systems Engineering 1 Assistant Professor
Graduate School
Graduate School of Engineering
Undergraduate School
School of Engineering Mechanical and Aerospace Engineering
Title
Assistant Professor
Contact information
メールアドレス
Other name(s)
KIM Jeonghyun
External link

Degree 3

  1. Doctor of Philosophy ( 2017.9   The University of Tokyo ) 

  2. Master of Engineering ( 2014.9   The University of Tokyo ) 

  3. Bachelor of Engineering ( 2010.5   The University of Sydney ) 

Research Interests 5

  1. regenerative medicine

  2. tissue engineering

  3. biomedical engineering

  4. biomechanics

  5. mechanobiology

Research Areas 1

  1. Life Science / Biomedical engineering

Research History 2

  1. Kyoto University

    2018.11 - 2021.3

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    Country:Japan

  2. The University of Tokyo

    2017.4 - 2018.10

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    Country:Japan

Education 3

  1. The University of Tokyo   Graduate School of Engineering   Mechanical Engineering

    2014.10 - 2017.9

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    Country: Japan

  2. The University of Tokyo   Graduate School of Engineering   Mechanical Engineering

    2012.10 - 2014.9

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    Country: Japan

  3. The University of Sydney   Faculty of Engineering   Mechanical Engineering (Biomedical)

    2006.3 - 2010.5

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    Country: Australia

    Notes: Honours degreee

Professional Memberships 3

  1. 日本生体医工学会

  2. 日本再生医療学会

  3. 日本機械学会

Committee Memberships 6

  1. 日本機械学会 バイオエンジニアリング部門   若手による次世代戦略委員会  

    2022.4 - 2024.3   

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    Committee type:Academic society

  2. 日本機械学会 バイオエンジニアリング部門   広報委員  

    2022.4 - 2024.3   

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    Committee type:Academic society

  3. The 32nd Biofrontier conference   Steering committee member  

    2021.9 - 2022.1   

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    Committee type:Academic society

  4. The 11th Asian-Pacific Conference on Biomechanics   Steering committee member  

    2021.6 - 2021.12   

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    Committee type:Academic society

  5. The Korean Institute of Chemical Engineering (Japan region)   Director of Business Affairs  

    2021.1 - 2021.12   

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    Committee type:Academic society

  6. The Korean Scientists and Engineers Associate in Japan   Bioengineering subcommittee chair  

    2018.7 - 2021.3   

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    Committee type:Academic society

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Awards 15

  1. 日本機械学会東海支部奨励賞

    2022.3   日本機械学会東海支部  

    Jeonghyun Kim

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. The Outstanding Abstract Award Runner-up

    2021.12   The 11th Asian-Pacific Conference on Biomechanics  

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    Award type:Award from international society, conference, symposium, etc.  Country:Japan

  3. 2020 JBSE Graphics of the Year Award

    2021.6   Journal of Biomechanical Science and Engineering  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  4. 2020 JBSE Papers of the Year Award

    2021.6   Journal of Biomechanical Science and Engineering  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  5. The Yamaguchi Medal

    2019.11   Asian-Pacific Conference on Biomechanics  

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    Award type:Award from international society, conference, symposium, etc.  Country:Taiwan, Province of China

    Awarded for outstanding young investigator in soft tissue mechanics

  6. The Best Oral Presentation Award

    2019.8   The 4th Africa International Biotechnology and Biomedical Conference  

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    Award type:Award from international society, conference, symposium, etc.  Country:Kenya

  7. The Academic Excellence Award

    2019.2   Korean Scientists and Engineers Association in Japan  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  8. The Outstanding Young Researcher Presentation Award

    2018.7   The 8th World Congress of Biomechanics  

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    Award type:Award from international society, conference, symposium, etc.  Country:Ireland

  9. The Best Paper Award

    2016.10   Japanese Journal of Clinical Biomechanics  

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    Award type:Honored in official journal of a scientific society, scientific journal  Country:Japan

  10. The Outstanding Student Poster Award

    2022.6   日本機械学会 第34回バイオエンジニアリング講演会   マウス軟骨前駆細胞の3次元スフェロイド培養による肥大軟骨分化およびアポトーシス誘導

    富田航世,キム・ジョンヒョン,前田英次郎,松本健郎

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  11. The Outstanding Student Poster Award

    2022.6   日本機械学会 第34回バイオエンジニアリング講演会   腱 Elastic recoil 挙動におけるコラーゲンとエラスチンの役割解明を目的としたクリンプ構造の評価と動的力学特性の解析

    石崎裕聖,キム・ジョンヒョン,松本健郎,前田英次郎

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  12. 優秀講演賞

    2022.3   日本機械学会東海支部 第53回学生員卒業研究発表講演会   静水圧刺激がマウス骨芽前駆細胞の細胞形状・増殖に与える影響

    水島 慎吾, キム ジョンヒョン, 前田 英次郎, 松本 健郎

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  13. 優秀講演賞

    2022.3   日本機械学会東海支部 第53回学生員卒業研究発表講演会   組織透明化手法による3次元骨細胞スフェロイド内部の細胞核形状評価

    稲垣 貴士, キム ジョンヒョン, 前田 英次郎, 松本 健郎

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  14. 優秀講演賞

    2022.3   日本機械学会東海支部 第53回学生員卒業研究発表講演会   イベリアトゲイモリ大腿骨損傷部の再生現象解明に関する研究

    伊藤 優作, キム ジョンヒョン, 松本 健郎, 前田 英次郎

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  15. The Outstanding Student Presentation Award

    2022.1   The 32nd Biofrontier conference   Elucidation of mechanical characteristics of Xenopus laevis embryos by seamless uniaxial tension-compression test

    Ryosuke Saito, Hiromasa Ninomiya, Jeonghyun Kim, Eijiro Maeda, Atsuaka Tamura, Takeo Matsumoto

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    Award type:Award from Japanese society, conference, symposium, etc. 

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Papers 18

  1. Effect of chemically induced osteogenesis supplements on multicellular behavior of osteocytic spheroids

    Kim J., Inagaki T., Sunaga J., Adachi T., Matsumoto T.

    Biochemical and Biophysical Research Communications   Vol. 622   page: 79 - 85   2022.9

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    Language:Japanese   Publisher:Biochemical and Biophysical Research Communications  

    Understanding in multicellular behaviors in three-dimensional (3D) culture models such as organoids is important to help us better comprehend the mechanisms of the morphogenesis and functions of diverse organs in vivo cellular environment. In this study, we elucidated the multicellular behaviors of the osteocytic spheroids in response to the chemically induced osteogenesis supplements (OS). Particularly, we conducted 1) size change measurement, 2) fusion experiment, and 3) collagen embedding experiment of spheroids, in response to the OS. We found out that the OS alters the multicellular behaviors of the spheroid by greater reduction in the size change measurement and slowing down the speed of fusion experiment and collagen embedding experiment of the spheroids. We also highlighted that the driving force of these changes was the tight actin filaments generated on the surface of the spheroids. Hence, the results altogether indicate that the spheroid model exerted the different multicellular behaviors against the differentiation capability. This study will contribute to understanding the multicellular behaviors of the 3D culture model reconstructed by the cells with greater cell-cell interaction force.

    DOI: 10.1016/j.bbrc.2022.07.026

    Scopus

    PubMed

  2. Dependency of deformation of cell nucleus on stretch direction of tissue: Relation to anisotropic response of aortic media to hypertension

    Fan Y., Wang J., Kim J., Maeda E., Matsumoto T.

    Journal of the Mechanical Behavior of Biomedical Materials   Vol. 133   page: 105326   2022.9

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    Language:Japanese   Publisher:Journal of the Mechanical Behavior of Biomedical Materials  

    The deformation of the cell nucleus may cause dispersion of chromatin and eventually enhance transcription, translation, and protein expression. If this happens in the hypertensive artery, an excessive stretch of smooth muscle cell (SMC) nuclei caused by hypertension may provoke wall thickening. Here, we measured deformation of SMC nuclei in rabbit thoracic aortas stretched in different directions. Thin 0.2-mm-thick specimens were sliced in the direction perpendicular to their axial and circumferential directions, and stretched in the circumferential and axial directions, respectively. The deformation of the actin filament (AF) network was similar to that of the whole tissue, whereas the deformation of the nucleus was significantly smaller than the others. Notably, the nucleus seldom deformed when the tissue was stretched in the axial direction. A novel cell model in which the nucleus is connected to the extracellular matrix via the AF network successfully explained the relative unresponsiveness of the nucleus to the axial stretch. It has been pointed out that stress is maintained constant in the circumferential direction but not in the axial direction in the artery wall during hypertension. The relative unresponsiveness of the nucleus to the axial stretch represented in this study explains this phenomenon.

    DOI: 10.1016/j.jmbbm.2022.105326

    Scopus

    PubMed

  3. Spheroid culture for chondrocytes triggers the initial stage of endochondral ossification

    Kim Jeonghyun, Tomida Kosei, Matsumoto Takeo, Adachi Taiji

    Biotechnology and Bioengineering     2022.8

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  4. Internal radial perfusion bioreactor promotes decellularized and recellularization of rat uterine tissue. Reviewed

    Narintadeach Charoensombut , Kinyoshi Kawabata, Jeonghyun Kim, Minki Chang, Tsuyoshi Kimura, Akio Kishida, Takashi Ushida, Katsuko Furukawa

    Journal of Bioscience and Bioengineering   Vol. 133 ( 1 ) page: 83 - 88   2022.1

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    Language:English  

    DOI: 10.1016/j.jbiosc.2021.09.007

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  5. Comparative gene expression analysis for pre-osteoblast MC3T3-E1 cells under non-adhesive culture toward osteocyte differentiation Reviewed

    Kim Jeonghyun, Kigami Hiroyuki, Adachi Taiji

    Journal of Bioscience and Bioengineering   Vol. 132 ( 6 ) page: 651 - 656   2021.12

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    Language:Japanese   Publisher:Journal of Bioscience and Bioengineering  

    Osteocytes play an important role to modulate the bone remodeling and are also known as terminally differentiated cells originated from the osteoblast precursor cells, but its differentiation mechanism remains unclear. Since an efficient in vitro method to evoke the osteocyte differentiation from the osteoblast precursor cells has not been established, we conducted the comparative gene expression analysis for mouse pre-osteoblast MC3T3-E1 cells in order to elucidate the key factors to induce the osteocyte differentiation from the pre-osteoblast cells. In this study, we prepared four different culture environments by modulating their cell-substrate interaction and cell–cell interaction; (i) low and (ii) high cell density on the adhesive culture models, and (iii) low and (iv) high cell density on the non-adhesive floating culture models. By comparing these conditions in terms of cell-substrate and cell–cell interaction, we showed that the elimination of cell-substrate interaction under non-adhesive floating culture greatly up-regulated the gene expression of osteocyte markers in the pre-osteoblast cells. Moreover, the presence of moderate cell–cell interaction in the non-adhesive spheroid culture further enhanced the up-regulation of osteocyte markers for the pre-osteoblast cells. The results altogether suggest the most appropriate culture environment to induce the in vitro osteocyte differentiation of pre-osteoblast cells.

    DOI: 10.1016/j.jbiosc.2021.09.004

    Web of Science

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    PubMed

  6. Modulation of <i>Sost</i> Gene Expression Under Hypoxia in Three-Dimensional Scaffold-Free Osteocytic Tissue. Reviewed

    Kim J, Adachi T

    Tissue engineering. Part A   Vol. 27 ( 15-16 ) page: 1037 - 1043   2021.8

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    Language:English  

    DOI: 10.1089/ten.TEA.2020.0228

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  7. Cell-fate decision of mesenchymal stem cells toward osteocyte differentiation is committed by spheroid culture Reviewed

    Jeonghyun Kim, Taiji Adachi

    Scientific Reports   Vol. 11 ( 1 ) page: 13204   2021.6

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  8. Uniaxially-fixed mechanical boundary condition elicits cellular alignment in collagen matrix with induction of osteogenesis Reviewed

    Jeonghyun Kim, Keiichi Ishikawa, Junko Sunaga, Taiji Adachi

    Scientific Reports   Vol. 11 ( 9009 )   2021.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1038/s41598-021-88505-z

  9. Characterization of self-organized osteocytic spheroids using mouse osteoblast-like cells Invited Reviewed

    Jeonghyun Kim, Hiroyuki Kigami, Taiji Adachi

    Journal of Biomechanical Science and Engineering     2020.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1299/jbse.20-00227

  10. Acquired contractility ability in human endometrial stromal cells by passive loading of cyclic tensile stretch Reviewed

    Jeonghyun Kim, Takashi Ushida, Kevin Montagne, Yasushi Hirota, Osamu Yoshino, Takehiro Hiraoka, Yutaka Osuga, Katsuko Furukawa

        2020.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1038/s41598-020-65884-3

  11. Cell condensation triggers the differentiation of osteoblast precursor cells to osteocyte-like cells Reviewed

    Jeonghyun Kim, Taiji Adachi

      Vol. 7 ( 288 )   2019.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.3389/fbioe.2019.00288

  12. Dependency of deformation of cell nucleus on stretch direction of tissue: Relation to anisotropic response of aortic media to hypertension Reviewed

    Yong Fan, Junfeng Wang, Jeonghyun Kim, Eijiro Maeda, Takeo Matsumoto

    Journal of the Mechanical Behavior of Biomedical Materials   Vol. 133 ( 105326 )   2022.9

  13. Three-dimensional culture technology: Self-organized spheroid culture drives osteocytogenesis Reviewed

    Jeonghyun Kim, Taiji Adachi

        2021.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (international conference proceedings)  

    DOI: https://doi.org/10.1109/LifeTech52111.2021.9391919

  14. Fabrication of extracellular matrix hydrogel derived from uterine tissues Reviewed

    Kinyoshi Kawabata, Narintadeach Charoensombut, Jeonghyun Kim, Tsuyoshi Kimura, Akio Kishida, Takashi Ushida, Katsuko Furukawa

      Vol. 41   page: 287 - 292   2020

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  15. Fabrication of uterine decellularized matrix using high hydrostatic pressure through depolymerization of actin filaments Invited Reviewed

    Jeonghyun Kim, Shu Takeda, Narintadeach Charoensombut, Kinyoshi Kawabata, Yugo Kishimoto, Tsuyoshi Kimura, Akio Kishida, Takashi Ushida, Katsuko Furukawa

      Vol. 14 ( 3 ) page: 19-00097   2019.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1299/jbse.19-00097

  16. Hypergravity down-regulates c-fos gene expression via ROCK/Rho-GTP and the PI3K signaling pathway in murine ATDC5 chondroprogenitor cells Reviewed

    Jeonghyun Kim, Kevin Montagne, Hidetoshi Nemoto, Takashi Ushida, Katsuko Furukawa

      Vol. 12 ( 9 ) page: e0185394   2017.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1371/journal.pone.0185394. eCollection 2017.

  17. Involvement of the mTOR pathway in redifferentiation of bovine chondrocytes under dynamic hydrostatic loading Reviewed

    Kevin Montagne, Dongig Oh, Jeonghyun Kim, Takashi Ushida, Katsuko S Furukawa

      Vol. 37   page: 1 - 8   2016.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  18. Enhanced chondrogenesis with upregulation of PKR using a novel hydrostatic pressure bioreactor Reviewed

    Jeonghyun Kim, Kevin Montagne, Takashi Ushida, Katsuko S Furukawa

      Vol. 79 ( 2 ) page: 239 - 241   2014.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1080/09168451.2014.975184.

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Books 1

  1. 最先端ナノライフシステム研究

    キム ジョンヒョン,前田 英次郎,松本 健郎( Role: Contributor ,  力で組織・細胞を制御する)

    丸善プラネット  2022 

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    Book type:Textbook, survey, introduction

Presentations 11

  1. Induction of osteocyte differentiation for mesenchymal stem cells in 3D scaffold-free spheroid culture

    Jeonghyun Kim, Taiji Adachi, Takeo Matsumoto

    Tissue Engineering and Regenerative Medicine International Society – Asia-Pacific Conference 2022 (TERMIS-AP 2022)  2022.10.7 

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    Event date: 2022.10

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Jeju   Country:Korea, Republic of  

  2. Differentiation fate of mesenchymal stem cells toward osteocyte is determined by actin balancing International conference

    Jeonghyun Kim, Taiji Adachi

    The 11th Asian-Pacific Conference on Biomechanics  2021.12.3 

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    Event date: 2021.12

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto, Japan  

  3. 3次元スフェロイド培養による骨細胞分化誘導の研究

    Jeonghyun Kim, Taiji Adachi

    第60回日本生体医工学会大会   2021.6.16  日本生体医工学会

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  4. 三次元骨細胞組織モデルを用いた細胞バイオメカニクス

    Jeonghyun Kim, Taiji Adachi

    日本機械学会2021年度年次大会  2021.9.7  日本機械学会

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  5. Pre-osteoblasts in three-dimensional spheroids exert osteocyte-likeness International conference

    Jeonghyun Kim, Taiji Adachi

    The 26th Congress of the European Society of Biomechanics   2021.7.13  European Society of Biomechanics

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    Language:English   Presentation type:Oral presentation (general)  

    Country:Italy  

  6. Intracellular tension of osteoblast in collagen gel elicits osteocyte alignment under uniaxially-fixed boundary condition Invited International conference

    Jeonghyun Kim, Keiichi Ishikawa, Junko Sunaga, Taiji Adachi

    The 2nd Joint Meeting of the European Society for Clinical Hemorheology and Microcirculation, the International Society for Clinical Hemorheology, and the International Society of Biorheology (ESCHM-ISCH-ISB 2021)   2021.7.7  The 2nd Joint Meeting of the European Society for Clinical Hemorheology and Microcirculation, the International Society for Clinical Hemorheology, and the International Society of Biorheology (ESCHM-ISCH-ISB 2021)

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    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  7. 骨芽細胞様細胞を用いた三次元構造体スフェロイドの骨細胞分化モデルへの応用

    Jeonghyun Kim, Taiji Adachi

    第33回バイオエンジニアリング講演会  2021.6.26  日本機械学会

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    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  8. Generation of tight actin filaments in response to osteogenesis supplements modulated the mechanical behaviors of osteocytic spheroids

    キム・ジョンヒョン , 安達泰治 , 松本健郎

    日本機械学会 2022年度年次大会  2022.9.13 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  9. Modulation of mechanical environment to induce osteocyte differentiation of mesenchymal stem cells International conference

    Jeonghyun Kim, Takashi Inagaki, Taiji Adachi, Takeo Matsumoto

    9th World Congress of Biomechanics  2022.7.12  The World Congress of Biomechanics

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    Event date: 2022.7

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Taiwan   Country:Taiwan, Province of China  

  10. Effect of chemical osteogenesis induction on mechanical behavior of 3D osteocytic spheroids

    キム・ジョンヒョン, 安達泰治, 松本健郎

    第61回日本生体医工学会大会  2022.6.28  日本生体医工学会

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:新潟   Country:Japan  

  11. 骨細胞スフェロイドの機械的挙動に対する 骨分化誘導剤の影響

    キム・ジョンヒョン, 安達泰治, 松本健郎

    第45回日本バイオレオロジー学会年会  2022.6.4  日本バイオレオロジー学会

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川   Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 3

  1. 骨オルガノイド構築と骨細胞分化機構の解明

    2022.9 - 2024.3

    立松財団 A1.特別研究助成 

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    Grant type:Competitive

    Grant amount:\3000000

  2. 3次元培養モデルを用いた静水圧負荷による骨細胞分化制御に関する研究

    2022.8 - 2023.7

    内藤科学技術振興財団 研究助成金 

    Kim Jeonghyun

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000

  3. Development of 4D measurement technology for bone-cartilage formation dynamics using 3D tissue-engineered constructs

    2021.4 - 2023.3

    Grant for Biomedical Engineering Research (Encouragement of Research), the Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4000000

KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. Morphogenesis-based Manufacturing: Construction of optimal structures based on mechanical response of cells

    Grant number:21H04533  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\400000

  2. Scaffold-free tissue積層化による3次元骨軟骨モデル構築

    Grant number:20K20181  2020.4 - 2023.3

    日本学術振興会  若手研究 

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    Authorship:Principal investigator 

    Grant amount:\4160000

  3. 骨形成再現に向けた旋回培養法による骨オルガノイド大量作製及び新たな活用法構築

    Grant number:19K23604  2019.8 - 2021.3

    日本学術振興会  研究活動スタート支援 

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    Authorship:Principal investigator 

    Grant amount:\2860000

  4. 脱細胞担体と機械的刺激を用いた子宮組織の再生と子宮着床パッチの開発

    Grant number:17J07735  2017.4 - 2018.10

    日本学術振興会  特別研究員奨励費  

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    Authorship:Principal investigator 

    Grant amount:\1940000

 

Teaching Experience (On-campus) 2

  1. 材料力学第2及び演習

    2021

  2. 物理学実験

    2021