Updated on 2024/10/09

写真a

 
KIM Jeonghyun
 
Organization
Graduate School of Engineering Mechanical Systems Engineering 1 Assistant Professor
Graduate School
Graduate School of Engineering
Undergraduate School
School of Engineering Mechanical and Aerospace Engineering
Title
Assistant Professor
Contact information
メールアドレス
Homepage
https://biomech-lab.com/
Other name(s)
KIM Jeonghyun
External link

Degree 3

  1. Doctor of Philosophy （ 2017.9   The University of Tokyo ） 

  2. Master of Engineering （ 2014.9   The University of Tokyo ） 

  3. Bachelor of Engineering （ 2010.5   The University of Sydney ） 

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Research Interests 5

  1. regenerative medicine

  2. tissue engineering

  3. biomedical engineering

  4. biomechanics

  5. mechanobiology

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Research Areas 3

  1. Life Science / Biomedical engineering

  2. Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Biofunction and bioprocess engineering

  3. Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Mechanics of materials and materials

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Research History 3

  1. Nagoya University   Assistant Professor

    2021.4

  2. Kyoto University

    2018.11 - 2021.3

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    Country：Japan

  3. The University of Tokyo

    2017.4 - 2018.10

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    Country：Japan

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Education 3

  1. The University of Tokyo   Graduate School of Engineering   Mechanical Engineering

    2014.10 - 2017.9

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    Country： Japan

  2. The University of Tokyo   Graduate School of Engineering   Mechanical Engineering

    2012.10 - 2014.9

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    Country： Japan

  3. The University of Sydney   Faculty of Engineering   Mechanical Engineering (Biomedical)

    2006.3 - 2010.5

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    Country： Australia

    Notes： Honours degreee

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Professional Memberships 4

  1. 日本生体医工学会

  2. 日本再生医療学会

  3. 日本機械学会

  4. The Japanese Society of Biorheology

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Committee Memberships 9

  1. 日本機械学会 第36回バイオエンジニアリング講演会   実行委員会  

    2023.12 - 2024.5   

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    Committee type：Academic society

  2. 日本機械学会 バイオエンジニアリング講演会   『静水圧メカノバイオロジー』セッションオーガナイザー  

    2023.11   

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    Committee type：Academic society

  3. 日本機械学会 年次大会   『細胞メカニクス』セッションオーガナイザー  

    2022.10   

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    Committee type：Academic society

  4. 日本機械学会 バイオエンジニアリング部門   広報委員  

    2022.4 - 2024.3   

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    Committee type：Academic society

  5. 日本機械学会 バイオエンジニアリング部門   若手による次世代戦略委員会  

    2022.4 - 2024.3   

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    Committee type：Academic society

  6. The 32nd Biofrontier conference   Steering committee member  

    2021.9 - 2022.1   

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    Committee type：Academic society

  7. The 11th Asian-Pacific Conference on Biomechanics   Steering committee member  

    2021.6 - 2021.12   

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    Committee type：Academic society

  8. The Korean Institute of Chemical Engineering (Japan region)   Director of Business Affairs  

    2021.1 - 2021.12   

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    Committee type：Academic society

  9. The Korean Scientists and Engineers Associate in Japan   Bioengineering subcommittee chair  

    2018.7 - 2021.3   

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    Committee type：Academic society

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Awards 21

  1. The 32rd Seguchi Award

    2024.6   The Japan Society of Mechanical Engineers, Bioengineering Division  

    Jeonghyun Kim

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    Award type：International academic award (Japan or overseas) 

  2. 2023年度日本生体医工学会東海支部研究奨励賞

    2023.10   日本生体医工学会   静水圧に応答する3次元培養骨細胞モデル

    キム・ジョンヒョン，新岡琴音，前田英次郎，松本健郎

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    Award type：Award from Japanese society, conference, symposium, etc. 

  3. 日本機械学会東海支部奨励賞

    2022.3   日本機械学会東海支部  

    Jeonghyun Kim

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  4. The Outstanding Abstract Award Runner-up

    2021.12   The 11th Asian-Pacific Conference on Biomechanics  

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    Award type：Award from international society, conference, symposium, etc.  Country：Japan

  5. 2020 JBSE Graphics of the Year Award

    2021.6   Journal of Biomechanical Science and Engineering  

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    Award type：Honored in official journal of a scientific society, scientific journal  Country：Japan

  6. 2020 JBSE Papers of the Year Award

    2021.6   Journal of Biomechanical Science and Engineering  

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    Award type：Honored in official journal of a scientific society, scientific journal  Country：Japan

  7. The Yamaguchi Medal

    2019.11   Asian-Pacific Conference on Biomechanics  

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    Award type：Award from international society, conference, symposium, etc.  Country：Taiwan, Province of China

    Awarded for outstanding young investigator in soft tissue mechanics

  8. The Best Oral Presentation Award

    2019.8   The 4th Africa International Biotechnology and Biomedical Conference  

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    Award type：Award from international society, conference, symposium, etc.  Country：Kenya

  9. The Academic Excellence Award

    2019.2   Korean Scientists and Engineers Association in Japan  

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    Award type：Honored in official journal of a scientific society, scientific journal  Country：Japan

  10. The Outstanding Young Researcher Presentation Award

    2018.7   The 8th World Congress of Biomechanics  

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    Award type：Award from international society, conference, symposium, etc.  Country：Ireland

  11. The Best Paper Award

    2016.10   Japanese Journal of Clinical Biomechanics  

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    Award type：Honored in official journal of a scientific society, scientific journal  Country：Japan

  12. 若手優秀講演賞

    2023.12   日本機械学会 第34回バイオフロンティア講演会   摺鉢面上のMC3T3-E1細胞挙動に及ぼす細胞内張力の影響

    石黒　恵奨，王　軍鋒，キム　ジョンヒョン，前田　英次郎，松本　健郎

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  13. The Best Presentation Award

    2023.3   日本機械学会東海支部 第72期総会・講演会 TOKAI ENGINEERING COMPLEX 2023 (TEC23)   スフェロイド培養法によるマウス軟骨前駆細胞の肥大化軟骨細胞分化誘導

    富田航世，キム・ジョンヒョン，前田英次郎，松本健郎

  14. The Best Presentation Award

    2023.3   日本機械学会東海支部 第54回学生員卒業研究発表講演会   繰返引張下の重層化したMC3T3-E1細胞の上下層で異なる配向の原因解明に関する研究

    鈴木秀一郎，王軍鋒，キム・ジョンヒョン，前田英次郎，松本健郎

  15. 若手優秀講演賞

    2022.12   日本機械学会 第33回バイオフロンティア講演会   電界紡糸法により成膜したエラスチン組織の力学挙動解析

    篠川晃佑，キム・ジョンヒョン，鳴瀧彩絵，松本健郎，前田英次郎

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    Award type：Award from Japanese society, conference, symposium, etc. 

  16. The Outstanding Student Poster Award

    2022.6   日本機械学会 第34回バイオエンジニアリング講演会   マウス軟骨前駆細胞の３次元スフェロイド培養による肥大軟骨分化およびアポトーシス誘導

    富田航世,キム・ジョンヒョン,前田英次郎,松本健郎

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  17. The Outstanding Student Poster Award

    2022.6   日本機械学会 第34回バイオエンジニアリング講演会   腱 Elastic recoil 挙動におけるコラーゲンとエラスチンの役割解明を目的としたクリンプ構造の評価と動的力学特性の解析

    石崎裕聖,キム・ジョンヒョン,松本健郎,前田英次郎

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  18. 優秀講演賞

    2022.3   日本機械学会東海支部 第53回学生員卒業研究発表講演会   イベリアトゲイモリ大腿骨損傷部の再生現象解明に関する研究

    伊藤 優作, キム ジョンヒョン, 松本 健郎, 前田 英次郎

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  19. 優秀講演賞

    2022.3   日本機械学会東海支部 第53回学生員卒業研究発表講演会   静水圧刺激がマウス骨芽前駆細胞の細胞形状・増殖に与える影響

    水島 慎吾, キム ジョンヒョン, 前田 英次郎, 松本 健郎

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  20. 優秀講演賞

    2022.3   日本機械学会東海支部 第53回学生員卒業研究発表講演会   組織透明化手法による３次元骨細胞スフェロイド内部の細胞核形状評価

    稲垣 貴士, キム ジョンヒョン, 前田 英次郎, 松本 健郎

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    Award type：Award from Japanese society, conference, symposium, etc.  Country：Japan

  21. The Outstanding Student Presentation Award

    2022.1   The 32nd Biofrontier conference   Elucidation of mechanical characteristics of Xenopus laevis embryos by seamless uniaxial tension-compression test

    Ryosuke Saito, Hiromasa Ninomiya, Jeonghyun Kim, Eijiro Maeda, Atsuaka Tamura, Takeo Matsumoto

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    Award type：Award from Japanese society, conference, symposium, etc. 

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Papers 25

  1. Spatiotemporal analysis of multi-scale cell structure in spheroid culture reveals hypertrophic chondrocyte differentiation

    Tomida, K; Kim, J; Maeda, E; Adachi, T; Matsumoto, T

    CELL AND TISSUE RESEARCH   Vol. 397 ( 3 ) page： 263 - 274   2024.9

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    Language：English   Publisher：Cell and Tissue Research  

    3D cell culture has emerged as a promising approach to replicate the complex behaviors of cells within living organisms. This study aims to analyze spatiotemporal behavior of the morphological characteristics of cell structure at multiscale in 3D scaffold-free spheroids using chondrogenic progenitor ATDC5 cells. Over a 14-day culture period, it exhibited cell hypertrophy in the spheroids regarding cellular and nuclear size as well as changes in morphology. Moreover, biological analysis indicated a signification up-regulation of normal chondrocyte as well as hypertrophic chondrocyte markers, suggesting early hypertrophic chondrocyte differentiation. Cell nuclei underwent changes in volume, sphericity, and distribution in spheroid over time, indicating alterations in chromatin organization. The ratio of chromatin condensation volume to cell nuclear volume decreased as the cell nuclei enlarged, potentially signifying changes in chromatin state during hypertrophic chondrocyte differentiation. Our image analysis techniques in this present study enabled detailed morphological measurement of cell structure at multi-scale, which can be applied to various 3D culture models for in-depth investigation.

    DOI： 10.1007/s00441-024-03905-7

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  2. Novel air-liquid interface culture model to investigate stiffness-dependent behaviors of alveolar epithelial cells

    Takahashi, Y; Ito, S; Wang, JF; Kim, J; Matsumoto, T; Maeda, E

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 708   page： 149791   2024.5

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    Language：English   Publisher：Biochemical and Biophysical Research Communications  

    Pulmonary alveoli are functional units in gas exchange in the lung, and their dysfunctions in lung diseases such as interstitial pneumonia are accompanied by fibrotic changes in structure, elevating the stiffness of extracellular matrix components. The present study aimed to test the hypothesis that such changes in alveoli stiffness induce functional alteration of epithelial cell functions, exacerbating lung diseases. For this, we have developed a novel method of culturing alveolar epithelial cells on polyacrylamide gel with different elastic modulus at an air-liquid interface. It was demonstrated that A549 cells on soft gels, mimicking the modulus of a healthy lung, upregulated mRNA expression and protein synthesis of surfactant protein C (SFTPC). By contrast, the cells on stiff gels, mimicking the modulus of the fibrotic lung, exhibited upregulation of SFTPC gene expression but not at the protein level. Cell morphology, as well as cell nucleus volume, were also different between the two types of gels.

    DOI： 10.1016/j.bbrc.2024.149791

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  3. Contributions of collagen and elastin to elastic behaviours of tendon fascicle

    Ishizaki, Y; Wang, JF; Kim, J; Matsumoto, T; Maeda, E

    ACTA BIOMATERIALIA   Vol. 176   page： 334 - 343   2024.3

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    Language：English   Publisher：Acta Biomaterialia  

    Tendon exhibits the capacity to be stretched and to return to its original length without suffering structural damage in vivo, a capacity known as elastic recoil. Collagen fibres are aligned longitudinally and elastin fibres mostly run parallel to collagen fibres in tendon. However, their interactions and contributions to tendon elastic behaviours are not well understood. The present study examined functional roles of collagen and elastin in tendon elastic behaviours using a variety of mechanical tests. We prepared three types of fascicle specimens from mouse tail tendon: fascicles freshly isolated, those digested with elastase in PBS to selectively remove elastin, and those incubated in PBS without elastase. A quasi-static tensile test demonstrated that elastase-treated fascicles had higher tangent moduli and strength compared to fresh and PBS fascicles. Cyclic stretching tests showed that fresh and PBS fascicles could withstand cyclic strain at both small and large amplitudes, but elastase-treated fascicles could only behave elastically to a limited degree. Fibre-sliding analysis revealed that fresh fascicles could be elongated both through stretching of collagen fibers and through movement of the fibres. However, elastase-treated fascicles could be stretched only via fibre stretching. This evidence suggests that normal tendons can be extended through both fibre stretching and fibre sliding, whereas tendons without elastin can only extend as much as collagen fibers can withstand. Accordingly, collagen fibres mainly contribute to tendon elastic behaviours by furnishing rigidity and elasticity, whereas elastin provides tendon viscoelasticity and also enables sliding of collagen fibres during elastic behaviours. Statement of significance: The present study revealed distinct mechanical functions of collagen and elastin fibres in elastic behaviours of mouse tail tendon fascicle using a variety of mechanical tests at both microscopic and macroscopic levels. It was demonstrated that collagen mainly governs tendon fascicle rigidity and elasticity, but only possesses limited extensibility, whereas elastin contributes to viscoelasticity and collagen fibre sliding, enabling elastic recoil behaviour against relatively large deformation. By their interactions, tendon can be elongated without suffering major structural damage and withstand a large magnitude of tensile force in response to mechanical loading. Such information should be particularly useful in designing collagen-based biomaterials such as artificial tendons, in that previous studies have merely considered collagen without incorporation of elastin.

    DOI： 10.1016/j.actbio.2024.01.014

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  4. Biomechanical analysis of tendon regeneration capacity of Iberian ribbed newts following transection injury: Comparison to a mouse model

    Sato, F; Masuda, Y; Suzuki, D; Hayashi, T; Iwasaki, T; Kim, J; Matsumoto, T; Maeda, E

    JOURNAL OF ORTHOPAEDIC RESEARCH   Vol. 42 ( 3 ) page： 607 - 617   2024.3

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    Language：English   Publisher：Journal of Orthopaedic Research  

    Adult mammals are known for their poor ability to regenerate tissues, including tendons. On the other hand, urodeles have become an important model in regenerative studies for their remarkable ability to regenerate various body parts and organs throughout life, such as limbs, retinas, or even the brain. However, little is known about their capacity to regenerate injured tendons. If newts can also repair tendons without scar formation, they may be a suitable animal model for tendon regeneration studies in other adult vertebrates. Therefore, the present study used Iberian ribbed newts to characterize mechanical and structural regeneration of tendons following transection, using tensile tests and multiphoton microscopy. A digital flexor tendon in a hindlimb was transected either partially or completely, and regenerated tendon was examined 6 and 12 weeks after the operation. Tensile strength of regenerated tendons was significantly less than normal at 6 weeks, but was remarkably recovered at 12 weeks, reaching levels comparable to those of uninjured tendons. On the other hand, mouse tendons demonstrated poor recovery of strength even after 12 weeks. Multiphoton microscopy revealed that tendon-like collagenous tissue bridges residual tendon stubs in newts, but disorganized scar-like tissue filled the injured location in mice. These findings highlight the remarkable capacity of newts to recover from tendon injury and confirm the utility of newts as a model to study tendon regeneration.

    DOI： 10.1002/jor.25705

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  5. 3D quantitative assessment for nuclear morphology in osteocytic spheroid with optical clearing technique

    Inagaki, T; Kim, J; Tomida, K; Maeda, E; Matsumoto, T

    INTEGRATIVE BIOLOGY   Vol. 15   2023.4

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    Language：English   Publisher：Integrative Biology  

    In recent years, three-dimensional (3D) cell culture has been attracting attention as a cell culture model that mimics an environment closer to that of a living organism. It is known that there is a close relationship between cell nuclear shape and cellular function, which highlights the importance of cell nucleus shape analysis in the 3D culture. On the other hand, it is difficult to observe the cell nuclei inside the 3D culture models because the penetration depth of the laser light under a microscope is limited. In this study, we adopted an aqueous iodixanol solution to the 3D osteocytic spheroids derived from mouse osteoblast precursor cells to make the spheroids transparent for 3D quantitative analysis. With a custom-made image analysis pipeline in Python, we found that the aspect ratio of the cell nuclei near the surface of the spheroid was significantly greater than that at the center, suggesting that the nuclei on the surface were deformed more than those at the center. The results also quantitatively showed that the orientation of nuclei in the center of the spheroid was randomly distributed, whereas those on the surface of the spheroid were oriented parallel to the surface of the spheroid. Our 3D quantitative method with an optical clearing technique will contribute to the 3D culture models including various organoid models to elucidate the nuclear deformation during the development of the organs.

    DOI： 10.1093/intbio/zyad007

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  6. Spheroid culture for chondrocytes triggers the initial stage of endochondral ossification

    Kim, J; Tomida, K; Matsumoto, T; Adachi, T

    BIOTECHNOLOGY AND BIOENGINEERING   Vol. 119 ( 11 ) page： 3311 - 3318   2022.11

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    Language：English   Publisher：Biotechnology and Bioengineering  

    Endochondral ossification is the process of bone formation derived from growing cartilage duringskeletal development. In previous studies, we provoked the osteocyte differentiation of osteoblast precursor cells under a three-dimensional (3D) culture model. To recapitulate the endochondral ossification, the present study utilized the self-organized scaffold-free spheroid model reconstructed by pre-chondrocyte cells. Within 2-day cultivation in the absence of the chemically induced chondrogenesis supplements, the chondrocyte marker was greatly expressed in the inner region of the spheroid, whereas the hypertrophic chondrocyte marker was strongly detected in the surface region of the spheroid. Notably, we found out that the gene expression levels of osteocyte markers were also greatly upregulated compared to the conventional 2D monolayer. Moreover, after long-term cultivation for 28 days, it induced morphological changes in the spheroid, such as cellular hypertrophy and death. In this study, in order to recapitulate the initial stage of the endochondral ossification, we highlighted the potentials of the 3D culture method to drive the hypertrophic chondrocyte differentiation of the pre-chondrocyte cells.

    DOI： 10.1002/bit.28203

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  7. Induction of osteocyte differentiation for mesenchymal stem cells in 3D scaffold-free spheroid culture

    Kim, J; Adachi, T; Matsumoto, T

    TISSUE ENGINEERING PART A   Vol. 28   page： 325 - 325   2022.10

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  8. Effect of chemically induced osteogenesis supplements on multicellular behavior of osteocytic spheroids

    Kim, J; Inagaki, T; Sunaga, J; Adachi, T; Matsumoto, T

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 622   page： 79 - 85   2022.9

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    Language：English   Publisher：Biochemical and Biophysical Research Communications  

    Understanding in multicellular behaviors in three-dimensional (3D) culture models such as organoids is important to help us better comprehend the mechanisms of the morphogenesis and functions of diverse organs in vivo cellular environment. In this study, we elucidated the multicellular behaviors of the osteocytic spheroids in response to the chemically induced osteogenesis supplements (OS). Particularly, we conducted 1) size change measurement, 2) fusion experiment, and 3) collagen embedding experiment of spheroids, in response to the OS. We found out that the OS alters the multicellular behaviors of the spheroid by greater reduction in the size change measurement and slowing down the speed of fusion experiment and collagen embedding experiment of the spheroids. We also highlighted that the driving force of these changes was the tight actin filaments generated on the surface of the spheroids. Hence, the results altogether indicate that the spheroid model exerted the different multicellular behaviors against the differentiation capability. This study will contribute to understanding the multicellular behaviors of the 3D culture model reconstructed by the cells with greater cell-cell interaction force.

    DOI： 10.1016/j.bbrc.2022.07.026

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  9. Dependency of deformation of cell nucleus on stretch direction of tissue: Relation to anisotropic response of aortic media to hypertension

    Fan, Y; Wang, JF; Kim, J; Maeda, E; Matsumoto, T

    JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS   Vol. 133   page： 105326   2022.9

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    Language：English   Publisher：Journal of the Mechanical Behavior of Biomedical Materials  

    The deformation of the cell nucleus may cause dispersion of chromatin and eventually enhance transcription, translation, and protein expression. If this happens in the hypertensive artery, an excessive stretch of smooth muscle cell (SMC) nuclei caused by hypertension may provoke wall thickening. Here, we measured deformation of SMC nuclei in rabbit thoracic aortas stretched in different directions. Thin 0.2-mm-thick specimens were sliced in the direction perpendicular to their axial and circumferential directions, and stretched in the circumferential and axial directions, respectively. The deformation of the actin filament (AF) network was similar to that of the whole tissue, whereas the deformation of the nucleus was significantly smaller than the others. Notably, the nucleus seldom deformed when the tissue was stretched in the axial direction. A novel cell model in which the nucleus is connected to the extracellular matrix via the AF network successfully explained the relative unresponsiveness of the nucleus to the axial stretch. It has been pointed out that stress is maintained constant in the circumferential direction but not in the axial direction in the artery wall during hypertension. The relative unresponsiveness of the nucleus to the axial stretch represented in this study explains this phenomenon.

    DOI： 10.1016/j.jmbbm.2022.105326

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  10. Internal radial perfusion bioreactor promotes decellularized and recellularization of rat uterine tissue. Reviewed

    Narintadeach Charoensombut , Kinyoshi Kawabata, Jeonghyun Kim, Minki Chang, Tsuyoshi Kimura, Akio Kishida, Takashi Ushida, Katsuko Furukawa

    Journal of Bioscience and Bioengineering   Vol. 133 ( 1 ) page： 83 - 88   2022.1

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    DOI： 10.1016/j.jbiosc.2021.09.007

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  11. Comparative gene expression analysis for pre-osteoblast MC3T3-E1 cells under non-adhesive culture toward osteocyte differentiation Reviewed

    Kim, J; Kigami, H; Adachi, T

    JOURNAL OF BIOSCIENCE AND BIOENGINEERING   Vol. 132 ( 6 ) page： 651 - 656   2021.12

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    Language：English   Publisher：Journal of Bioscience and Bioengineering  

    Osteocytes play an important role to modulate the bone remodeling and are also known as terminally differentiated cells originated from the osteoblast precursor cells, but its differentiation mechanism remains unclear. Since an efficient in vitro method to evoke the osteocyte differentiation from the osteoblast precursor cells has not been established, we conducted the comparative gene expression analysis for mouse pre-osteoblast MC3T3-E1 cells in order to elucidate the key factors to induce the osteocyte differentiation from the pre-osteoblast cells. In this study, we prepared four different culture environments by modulating their cell-substrate interaction and cell–cell interaction; (i) low and (ii) high cell density on the adhesive culture models, and (iii) low and (iv) high cell density on the non-adhesive floating culture models. By comparing these conditions in terms of cell-substrate and cell–cell interaction, we showed that the elimination of cell-substrate interaction under non-adhesive floating culture greatly up-regulated the gene expression of osteocyte markers in the pre-osteoblast cells. Moreover, the presence of moderate cell–cell interaction in the non-adhesive spheroid culture further enhanced the up-regulation of osteocyte markers for the pre-osteoblast cells. The results altogether suggest the most appropriate culture environment to induce the in vitro osteocyte differentiation of pre-osteoblast cells.

    DOI： 10.1016/j.jbiosc.2021.09.004

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  12. Modulation of <i>Sost</i> Gene Expression Under Hypoxia in Three-Dimensional Scaffold-Free Osteocytic Tissue. Reviewed

    Kim J, Adachi T

    Tissue engineering. Part A   Vol. 27 ( 15-16 ) page： 1037 - 1043   2021.8

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    Language：English  

    DOI： 10.1089/ten.TEA.2020.0228

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  13. Cell-fate decision of mesenchymal stem cells toward osteocyte differentiation is committed by spheroid culture Reviewed

    Jeonghyun Kim, Taiji Adachi

    Scientific Reports   Vol. 11 ( 1 ) page： 13204   2021.6

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  14. Uniaxially-fixed mechanical boundary condition elicits cellular alignment in collagen matrix with induction of osteogenesis Reviewed

    Jeonghyun Kim, Keiichi Ishikawa, Junko Sunaga, Taiji Adachi

    Scientific Reports   Vol. 11 ( 9009 )   2021.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s41598-021-88505-z

  15. Intracellular tension of osteoblast in collagen gel elicits osteocyte alignment under uniaxially-fixed boundary condition

    Kim, J; Ishikawa, K; Sunaga, J; Adachi, T

    BIORHEOLOGY   Vol. 58 ( 3-4 ) page： 161 - 161   2021

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  16. Characterization of self-organized osteocytic spheroids using mouse osteoblast-like cells Invited Reviewed

    Jeonghyun Kim, Hiroyuki Kigami, Taiji Adachi

    Journal of Biomechanical Science and Engineering     2020.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1299/jbse.20-00227

  17. Acquired contractility ability in human endometrial stromal cells by passive loading of cyclic tensile stretch Reviewed

    Jeonghyun Kim, Takashi Ushida, Kevin Montagne, Yasushi Hirota, Osamu Yoshino, Takehiro Hiraoka, Yutaka Osuga, Katsuko Furukawa

        2020.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s41598-020-65884-3

  18. Cell condensation triggers the differentiation of osteoblast precursor cells to osteocyte-like cells Reviewed

    Jeonghyun Kim, Taiji Adachi

      Vol. 7 ( 288 )   2019.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.3389/fbioe.2019.00288

  19. Dependency of deformation of cell nucleus on stretch direction of tissue: Relation to anisotropic response of aortic media to hypertension Reviewed

    Yong Fan, Junfeng Wang, Jeonghyun Kim, Eijiro Maeda, Takeo Matsumoto

    Journal of the Mechanical Behavior of Biomedical Materials   Vol. 133 ( 105326 )   2022.9

  20. Three-dimensional culture technology: Self-organized spheroid culture drives osteocytogenesis Reviewed

    Jeonghyun Kim, Taiji Adachi

        2021.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (international conference proceedings)  

    DOI： https://doi.org/10.1109/LifeTech52111.2021.9391919

  21. Fabrication of extracellular matrix hydrogel derived from uterine tissues Reviewed

    Kinyoshi Kawabata, Narintadeach Charoensombut, Jeonghyun Kim, Tsuyoshi Kimura, Akio Kishida, Takashi Ushida, Katsuko Furukawa

      Vol. 41   page： 287 - 292   2020

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  22. Fabrication of uterine decellularized matrix using high hydrostatic pressure through depolymerization of actin filaments Invited Reviewed

    Jeonghyun Kim, Shu Takeda, Narintadeach Charoensombut, Kinyoshi Kawabata, Yugo Kishimoto, Tsuyoshi Kimura, Akio Kishida, Takashi Ushida, Katsuko Furukawa

      Vol. 14 ( 3 ) page： 19-00097   2019.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1299/jbse.19-00097

  23. Hypergravity down-regulates c-fos gene expression via ROCK/Rho-GTP and the PI3K signaling pathway in murine ATDC5 chondroprogenitor cells Reviewed

    Jeonghyun Kim, Kevin Montagne, Hidetoshi Nemoto, Takashi Ushida, Katsuko Furukawa

      Vol. 12 ( 9 ) page： e0185394   2017.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1371/journal.pone.0185394. eCollection 2017.

  24. Involvement of the mTOR pathway in redifferentiation of bovine chondrocytes under dynamic hydrostatic loading Reviewed

    Kevin Montagne, Dongig Oh, Jeonghyun Kim, Takashi Ushida, Katsuko S Furukawa

      Vol. 37   page： 1 - 8   2016.9

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    Language：English   Publishing type：Research paper (scientific journal)  

  25. Enhanced chondrogenesis with upregulation of PKR using a novel hydrostatic pressure bioreactor Reviewed

    Jeonghyun Kim, Kevin Montagne, Takashi Ushida, Katsuko S Furukawa

      Vol. 79 ( 2 ) page： 239 - 241   2014.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1080/09168451.2014.975184.

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To the head of Papers.▲

Books 2

  1. オルガノイド研究 ～培養・作製、活用、臨床応用～

    キム・ジョンヒョン、安達泰治、松本健郎（ Role： Joint author ,  範囲:第２編 第１章 第２節『３次元培養技術を用いた骨細胞分化メカニズムの解明 』）

    エヌ・ティー・エス  2024.7  （ ISBN:ISBN978-4-86043-873-9 ）

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    Language：Japanese

  2. 最先端ナノライフシステム研究

    キム ジョンヒョン，前田 英次郎，松本 健郎（ Role： Contributor ,  力で組織・細胞を制御する）

    丸善プラネット  2022 

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    Book type：Textbook, survey, introduction

To the head of Books.▲

Presentations 30

  1. 階層的リンクル構造が未分化間葉系幹細胞に及ぼす研究

    キム ジョンヒョン, 永島 壮, 王 軍鋒, 前田 英次郎, 奥村 大, 松本 健郎

    日本機械学会 2024年度年次大会  2024.9.9 

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    Event date： 2024.9

    Presentation type：Oral presentation (general)  

    Venue：松山  

  2. Spatiotemporal analysis for hypertrophic chondrocyte differentiation in spheroid culture International conference

    Jeonghyun Kim, Kosei Tomida, Eijiro Maeda, Taiji Adachi, Takeo Matsumoto

    The 2024 Summer Biomechanics, Bioengineering, & Biotransport Conference (SB3C 2024)  2024.6.11 

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    Event date： 2024.6

    Language：English   Presentation type：Poster presentation  

    Venue：Wisconsin   Country：United States  

  3. ヒト間葉系幹細胞由来スフェロイドの圧縮に対する力学挙動評価

    キム ジョンヒョン, 稲垣 貴士, 前田 英次郎, 松本 健郎

    第47回日本バイオレオロジー学会年会  2024.6.8 

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    Event date： 2024.6

    Presentation type：Oral presentation (general)  

    Venue：東京  

  4. Effect of hydrostatic pressure on 3D scaffold-free osteocytic spheroids

    キム ジョンヒョン, 新岡 琴音, 前田 英次郎, 松本 健郎

    第63回日本生体医工学会大会  2024.5.25 

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    Event date： 2024.5

    Presentation type：Oral presentation (general)  

    Venue：鹿児島  

  5. 静⽔圧負荷が マウス⾻芽細胞様細胞由来スフェロイドの ⾻細胞分化に与える影響 Invited

    キム・ジョンヒョン, 新岡 琴音, 前田 英次郎, 松本 健郎

    日本機械学会 第36回バイオエンジニアリング講演会  2024.5.11  日本機械学会

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    Event date： 2024.5

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：名古屋  

  6. In vitro platforms to study biomechanics and mechanobiology for 3D spheroid models Invited International conference

    Jeonghyun Kim, Takashi Inagaki, Kotone Niioka, Eijiro Maeda, Takeo Matsumoto

    The 19th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2024)   2024.5.5  IEEE-NEMS

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    Event date： 2024.5

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Kyoto   Country：Japan  

  7. Biomechanical analysis in spheroid culture: Induction of hypertrophic chondrocyte differentiation International conference

    Jeonghyun Kim, Kosei Tomida, Eijiro Maeda, Taiji Adachi, Takeo Matsumoto

    The 12th Asian-Pacific Conference on Biomechanics   2023.11.16 

    　More details

    Event date： 2023.11

    Language：English   Presentation type：Oral presentation (general)  

  8. Application of hydrostatic pressure to facilitate the osteocyte differentiation in spheroid culture Invited

    Jeonghyun Kim, Kotone Niioka, Eijro Maeda, Taiji Adachi, Takeo Matsumoto

    The Korean Society of Mechanical Engineers Annual Meeting  2023.11.3 

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    Event date： 2023.11

    Language：English   Presentation type：Oral presentation (invited, special)  

  9. Cellular biomechanics using 3D spheroid culture for bone study Invited

    Jeonghyun Kim

    日本機械学会 2023年度年次大会  2023.9.3 

    　More details

    Event date： 2023.9

    Language：English   Presentation type：Oral presentation (invited, special)  

  10. Biomechanical analysis of osteocytic spheroids for bone tissue engineering applications Invited International conference

    Jeonghyun Kim , Takashi Inagaki , Eijiro Maeda , Taiji Adachi , Takeo Matsumoto

    The International Conference on Precision Engineering and Sustainable Manufacturing 2023 (PRESM2023)  2023.7.19 

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    Event date： 2023.7

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：Okinawa   Country：Japan  

  11. Actin filaments in response to chemical osteogenesis supplements alter the multicellular behavior of osteocytic spheroids International conference

    Jeonghyun Kim, Taiji Adachi, Takeo Matsumoto

    The 28th Congress of the European Society of Biomechanics  2023.7.11 

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    Event date： 2023.7

    Language：English   Presentation type：Poster presentation  

    Venue：Maastricht   Country：Netherlands  

  12. Measurement of multicellular behavior and mechanical properties in 3D osteocytic spheroids Invited

    キム ジョンヒョン, 稲垣 貴士, 前田 英次郎, 安達 泰治, 松本 健郎

    第62回日本生体医工学会大会  2023.5.20  日本生体医工学会

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    Event date： 2023.5

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    Venue：名古屋  

  13. In vitro spheroid culture for chondrogenic precursor ATDC5 cells provokes an initial stage of endochondral ossification

    Jeonghyun Kim, Kosei Tomida, Eijiro Maeda, Taij Adachi, Takeo Matsumoto

    The 4th International Symposium on Mechanobiology  2022.11.7  The Australian Society for Mechanobiology (AuSMB)

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    Event date： 2022.11

    Language：English  

    Venue：Sydney   Country：Australia  

  14. Induction of osteocyte differentiation for mesenchymal stem cells in 3D scaffold-free spheroid culture

    Jeonghyun Kim, Taiji Adachi, Takeo Matsumoto

    Tissue Engineering and Regenerative Medicine International Society – Asia-Pacific Conference 2022 (TERMIS-AP 2022)  2022.10.7 

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    Event date： 2022.10

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Jeju   Country：Korea, Republic of  

  15. Differentiation fate of mesenchymal stem cells toward osteocyte is determined by actin balancing International conference

    Jeonghyun Kim, Taiji Adachi

    The 11th Asian-Pacific Conference on Biomechanics  2021.12.3 

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    Event date： 2021.12

    Language：English   Presentation type：Poster presentation  

    Venue：Kyoto, Japan  

  16. Pre-osteoblasts in three-dimensional spheroids exert osteocyte-likeness International conference

    Jeonghyun Kim, Taiji Adachi

    The 26th Congress of the European Society of Biomechanics   2021.7.13  European Society of Biomechanics

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    Event date： 2021.7

    Language：English   Presentation type：Oral presentation (general)  

    Country：Italy  

  17. Intracellular tension of osteoblast in collagen gel elicits osteocyte alignment under uniaxially-fixed boundary condition Invited International conference

    Jeonghyun Kim, Keiichi Ishikawa, Junko Sunaga, Taiji Adachi

    The 2nd Joint Meeting of the European Society for Clinical Hemorheology and Microcirculation, the International Society for Clinical Hemorheology, and the International Society of Biorheology (ESCHM-ISCH-ISB 2021)   2021.7.7  The 2nd Joint Meeting of the European Society for Clinical Hemorheology and Microcirculation, the International Society for Clinical Hemorheology, and the International Society of Biorheology (ESCHM-ISCH-ISB 2021)

    　More details

    Event date： 2021.7

    Language：English   Presentation type：Oral presentation (invited, special)  

    Country：Japan  

  18. Assays for biomechanical analysis of spheroid culture mode Invited International conference

    Jeonghyun Kim, Kosei Tomida, Eijiro Maeda, Taiji Adachi, Takeo Matsumoto

    The 10th International Conference on Mechanics and Materials in Design 2024 (M2D2024)   2024.9.4 

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    Event date： 2024.9

    Language：English   Presentation type：Oral presentation (invited, special)  

    Venue：名古屋  

  19. ヒト間葉系幹細胞由来スフェロイドの圧縮に対する力学挙動評価

    キム・ジョンヒョン, 稲垣 貴士, 前田 英次郎, 松本 健郎

    第47回日本バイオレオロジー学会年会  2024.6.8  日本バイオレオロジー学会

    　More details

    Event date： 2024.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京  

  20. Effect of hydrostatic pressure on 3D scaffold-free osteocytic spheroids

    キム・ジョンヒョン, 新岡 琴音, 前田 英次郎, 松本 健郎

    第63回日本生体医工学会大会  2024.5.25  日本生体医工学会

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    Event date： 2024.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：鹿児島  

  21. Hydrostatic pressure-responsive 3D osteocytic culture model

    キム・ジョンヒョン, 新岡琴音, 前田英次郎, 松本健郎

    2023年度日本生体医工学会東海支部大会  2023.10.28 

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    Event date： 2023.10

  22. Application of spheroid culture to mimic the initial stage of endochondral ossification process

    キム・ジョンヒョン, 富田航世, 前田英次郎, 安達泰治, 松本健郎

    日本機械学会 2023年度年次大会  2023.9.6 

    　More details

    Event date： 2023.9

    Language：Japanese  

  23. Chemical osteogenesis supplements modulated the multicellular behaviors of osteocytic spheroids

    2023.3.23 

    　More details

    Event date： 2023.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  24. Generation of tight actin filaments in response to osteogenesis supplements modulated the mechanical behaviors of osteocytic spheroids

    キム・ジョンヒョン , 安達泰治 , 松本健郎

    日本機械学会 2022年度年次大会  2022.9.13 

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    Event date： 2022.9

    Language：Japanese   Presentation type：Oral presentation (general)  

  25. Modulation of mechanical environment to induce osteocyte differentiation of mesenchymal stem cells International conference

    Jeonghyun Kim, Takashi Inagaki, Taiji Adachi, Takeo Matsumoto

    9th World Congress of Biomechanics  2022.7.12  The World Congress of Biomechanics

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    Event date： 2022.7

    Language：English   Presentation type：Oral presentation (general)  

    Venue：Taiwan   Country：Taiwan, Province of China  

  26. Effect of chemical osteogenesis induction on mechanical behavior of 3D osteocytic spheroids

    キム・ジョンヒョン, 安達泰治, 松本健郎

    第61回日本生体医工学会大会  2022.6.28  日本生体医工学会

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：新潟   Country：Japan  

  27. 骨細胞スフェロイドの機械的挙動に対する 骨分化誘導剤の影響

    キム・ジョンヒョン, 安達泰治, 松本健郎

    第45回日本バイオレオロジー学会年会  2022.6.4  日本バイオレオロジー学会

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：神奈川   Country：Japan  

  28. ３次元スフェロイド培養による骨細胞分化誘導の研究

    Jeonghyun Kim, Taiji Adachi

    第60回日本生体医工学会大会   2021.6.16  日本生体医工学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  29. 三次元骨細胞組織モデルを用いた細胞バイオメカニクス

    Jeonghyun Kim, Taiji Adachi

    日本機械学会2021年度年次大会  2021.9.7  日本機械学会

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    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  30. 骨芽細胞様細胞を用いた三次元構造体スフェロイドの骨細胞分化モデルへの応用

    Jeonghyun Kim, Taiji Adachi

    第33回バイオエンジニアリング講演会  2021.6.26  日本機械学会

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    Language：Japanese   Presentation type：Poster presentation  

    Country：Japan  

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To the head of Presentations.▲

Research Project for Joint Research, Competitive Funding, etc. 9

  1. Emerging technologies to study biomechanical and mechanobiological characterization of bone, cartilage, muscle and tendon International coauthorship

    2025.2

    Nagoya – Melbourne Joint Research Workshops Fund 2024 

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    Authorship：Principal investigator  Grant type：Competitive

  2. ⾻形成促進に向けた静⽔圧負荷装置の開発

    2024.12 - 2025.12

    日東学術振興財団 第41回（2024年度）研究助成 

    キム・ジョンヒョン

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\200000

  3. 骨オルガノイドの創成と石灰化機構解明

    2024.6 - 2025.5

    日比科学技術振興財団 令和6年度 研究開発助成 

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1000000

  4. Emerging technologies to study biomechanical and mechanobiological characterization of bone, cartilage, muscle and tendon International coauthorship

    2023.9

    Nagoya – Melbourne Joint Research Workshops Fund 2023 

    Jeonghyun Kim, Kathryn Stok

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1252396

  5. 骨細胞の機械的シグナル伝達機構解明に向けた静水圧負荷装置の開発

    2023.4 - 2024.3

    シーシーアイ株式会社研究助成プログラム 

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1000000

  6. Practical application of bone regenerative medicine: Construction of 3D pellet culture model using pluripotent stem cells

    Grant number：1546  2023.3 - 2024.3

    The Hitachi Global Foundation  The Kurata Grants 

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1000000

  7. 骨オルガノイド構築と骨細胞分化機構の解明

    Grant number：No.5  2022.9 - 2024.3

    立松財団 A1.特別研究助成 

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    Grant type：Competitive

    Grant amount：\3000000

  8. ３次元培養モデルを用いた静水圧負荷による骨細胞分化制御に関する研究

    2022.8 - 2023.7

    内藤科学技術振興財団 研究助成金 

    Kim Jeonghyun

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1000000

  9. Development of 4D measurement technology for bone-cartilage formation dynamics using 3D tissue-engineered constructs

    2021.4 - 2023.3

    Grant for Biomedical Engineering Research (Encouragement of Research), the Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering 

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4000000

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To the head of Research Project for Joint Research, Competitive Funding, etc..▲

KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. Elucidation of osteocyte differentiation mechanism for establishment of bone organoids

    Grant number：23K17193  2023.4 - 2025.3

    Grant-in-Aid for Early-Career Scientists

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    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

  2. Morphogenesis-based Manufacturing: Construction of optimal structures based on mechanical response of cells

    Grant number：21H04533  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship：Coinvestigator(s)  Grant type：Competitive

    Grant amount：\400000

  3. Reconstruction of three-dimensional osteochondral model by multilayered scaffold-free tissue

    Grant number：20K20181  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    Kim Jeonghyun

    　 More details

    Authorship：Principal investigator 

    Grant amount：\4160000

    In this study, we fabricated and evaluated a cartilage scaffold-free tissue (SFT), which is a three-dimensional cell assembly derived from mouse chondroprogenitor ATDC5 cells. After long-term culture without addition of chemical differentiation supplements, hypertrophy of cells within the spheroids was confirmed, and apoptosis was also observed from the center of the spheroids. This is a phenomenon observed in the initial stage of endochondral ossification, and is a result showing the structural effect of the three-dimensional model. In addition, using human mesenchymal stem cell-derived spheroids, it was clarified that the multicellular behavior in the spheroids was greatly changed by chemical differentiation supplements. Moreover, we established an optical clearing technique necessary for cell observation inside the 3D spheroids and further developed a custom-made image analysis pipeline in Python to quantitatively evaluate cell nucleus shape in the spheroids.

  4. 力学刺激による核内DNAの分散誘導とこれを用いた細胞機能制御の試み：細胞周期の考慮

    Grant number：24K22404  2024.6 - 2026.3

    日本学術振興会  挑戦的研究(萌芽) 

    松本健郎、前田英次郎、キム・ジョンヒョン

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    Authorship：Coinvestigator(s)  Grant type：Competitive

    Grant amount：\600000

  5. New strategy for tendon healing using novel biomaterial eliciting cell mechanoresponse

    Grant number：24K00757  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

  6. 骨形成再現に向けた旋回培養法による骨オルガノイド大量作製及び新たな活用法構築

    Grant number：19K23604  2019.8 - 2021.3

    日本学術振興会  研究活動スタート支援 

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    Authorship：Principal investigator 

    Grant amount：\2860000

  7. 脱細胞担体と機械的刺激を用いた子宮組織の再生と子宮着床パッチの開発

    Grant number：17J07735  2017.4 - 2018.10

    日本学術振興会  特別研究員奨励費  

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    Authorship：Principal investigator 

    Grant amount：\1940000

▼display all

To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲

Industrial property rights 1

  1. ひずみ負荷装置

    松本健郎，河合尚之，前田英次郎，キム ジョンヒョン，王軍鋒

    　More details

    Applicant：名古屋大学

    Application no：2023-207010  Date applied：2023.12

To the head of Industrial property rights.▲
 

Teaching Experience (On-campus) 5

  1. 機械・航空宇宙工学科実験

    2024

  2. 物理学実験

    2022

  3. 材料力学第２及び演習

    2022

  4. 物理学実験

    2021

  5. 材料力学第２及び演習

    2021

To the head of Teaching Experience (On-campus).▲
 

Social Contribution 3

  1. 令和6年度 高大接続探究ゼミ『細胞を機械工学する』

    Role(s)：Lecturer,　Planner,　Organizing member

    2024.8

  2. UST Global Mentoring Conference

    Role(s)：Lecturer,　Planner

    2024.8

  3. 令和6年度 テクノサイエンスセミナー『力に応答する細胞を見よう』

    Role(s)：Lecturer,　Advisor,　Organizing member,　Demonstrator

    2024.4 - 2024.8

    　More details

    Type：Seminar, workshop

    東海地区の高校生に，名古屋大学大学院工学研究科機械システム工学専攻の研究教育について講義と実験を通した体験学習を行い，バイオメカニクス研究の楽しさと重要性を実感してもらう．同時に，参加者と大学の教員・学生との交流の場を提供する．

To the head of Social Contribution.▲