2022/04/12 更新

写真a

ナリタ シンゴ
成田 伸伍
NARITA Shingo
所属
医学部附属病院 救急科 病院助教
職名
病院助教

学位 1

  1. 学士(医学) ( 2010年3月   北海道大学 ) 

研究キーワード 2

  1. 脂肪細胞由来幹細胞

  2. 心筋再生

研究分野 1

  1. ライフサイエンス / 循環器内科学

 

論文 1

  1. No influence on tumor growth by intramuscular injection of adipose-derived regenerative cells: safety evaluation of therapeutic angiogenesis with cell therapy

    Suzuki Junya, Shimizu Yuuki, Tsuzuki Kazuhito, Pu Zhongyue, Narita Shingo, Yamaguchi Shukuro, Katagiri Takeshi, Iwata Etsuo, Masutomi Tomohiro, Fujikawa Yusuke, Shibata Rei, Murohara Toyoaki

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   320 巻 ( 1 ) 頁: H447 - H457   2021年1月

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    記述言語:日本語   出版者・発行元:American Journal of Physiology - Heart and Circulatory Physiology  

    Therapeutic angiogenesis with autologous stem/progenitor cells is a promising novel strategy for treatment of severe ischemic diseases. Human clinical trials utilizing autologous adipose-derived regenerative cells (ADRCs) have not reported treatmentrelated critical adverse effects thus far. However, there is still a large knowledge gap regarding whether treatment of ischemic diseases with angiogenic therapy using ADRCs would promote unfavorable angiogenesis associated with tumors in vivo. Herein, we addressed this clinical question using a mouse hindlimb ischemia (HLI) and simultaneous remote tumor implantation model. C57BL/6J background wild-type mice were injected with murine B16F10 melanoma cells on their back, 1 day before ischemic surgery. These mice were subjected to surgical unilateral hindlimb ischemia, followed by ADRC implantation or PBS injection into the hindlimb ischemic muscles on the next day. Intramuscular implantation of ADRCs enhanced tissue capillary density and blood flow examined by a laser Doppler blood perfusion analysis in hind limb. However, this therapeutic regimen for ischemic limb using ADRCs did not affect remote melanoma growth nor the density of its feeder artery, angiogenesis, and lymphatic vessels compared with the PBS group. In addition, no distant metastases were detected in any of the mice regardless of the group. In conclusion, local implantation of ADRCs promotes angiogenesis in response to tissue ischemia in the hindlimb without promoting remote tumor growth and related angio/lymphangiogenesis. Therapeutic angiogenesis to the ischemic hindlimb using ADRCs seems to be safe regarding remote tumor growth.

    DOI: 10.1152/ajpheart.00564.2020

    Web of Science

    Scopus

    PubMed

講演・口頭発表等 1

  1. Identification of critical six transcriptional factors for reprogramming of mouse adipose-derived regenerative cells toward cardiomyocytes and its therapeutic effect 国際会議

    Shingo Narita, Kazumasa Unno, Rei Shibata, Kazuhisa Kondo, Yuuki Shimizu, Katsuhiro Kato, Yusuke Fujikawa, Toyoaki Murohara

    American Heart Association Scientific Sessions 2021  2021年11月13日  American Heart Association

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    開催年月日: 2021年11月

    記述言語:英語   会議種別:ポスター発表  

    開催地:Boston, MA   国名:アメリカ合衆国