Updated on 2022/08/16


Nagoya University Hospital Emergency and Critical Care Medicine Assistant professor of hospital
Assistant professor of hospital

Degree 1

  1. 学士(医学) ( 2010.3   北海道大学 ) 

Research Interests 2

  1. 脂肪細胞由来幹細胞

  2. 心筋再生

Research Areas 1

  1. Life Science / Cardiology


Papers 4

  1. Direct reprogramming of adult adipose-derived regenerative cells toward cardiomyocytes using six transcriptional factors Reviewed

    Narita Shingo, Unno Kazumasa, Kato Katsuhiro, Okuno Yusuke, Sato Yoshitaka, Tsumura Yusuke, Fujikawa Yusuke, Shimizu Yuuki, Hayashida Ryo, Kondo Kazuhisa, Shibata Rei, Murohara Toyoaki

    ISCIENCE   Vol. 25 ( 7 ) page: 104651   2022.7

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    Authorship:Lead author   Language:Japanese  

    DOI: 10.1016/j.isci.2022.104651

    Web of Science


  2. No influence on tumor growth by intramuscular injection of adipose-derived regenerative cells: safety evaluation of therapeutic angiogenesis with cell therapy

    Suzuki Junya, Shimizu Yuuki, Tsuzuki Kazuhito, Pu Zhongyue, Narita Shingo, Yamaguchi Shukuro, Katagiri Takeshi, Iwata Etsuo, Masutomi Tomohiro, Fujikawa Yusuke, Shibata Rei, Murohara Toyoaki


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    Language:Japanese   Publisher:American Journal of Physiology - Heart and Circulatory Physiology  

    Therapeutic angiogenesis with autologous stem/progenitor cells is a promising novel strategy for treatment of severe ischemic diseases. Human clinical trials utilizing autologous adipose-derived regenerative cells (ADRCs) have not reported treatmentrelated critical adverse effects thus far. However, there is still a large knowledge gap regarding whether treatment of ischemic diseases with angiogenic therapy using ADRCs would promote unfavorable angiogenesis associated with tumors in vivo. Herein, we addressed this clinical question using a mouse hindlimb ischemia (HLI) and simultaneous remote tumor implantation model. C57BL/6J background wild-type mice were injected with murine B16F10 melanoma cells on their back, 1 day before ischemic surgery. These mice were subjected to surgical unilateral hindlimb ischemia, followed by ADRC implantation or PBS injection into the hindlimb ischemic muscles on the next day. Intramuscular implantation of ADRCs enhanced tissue capillary density and blood flow examined by a laser Doppler blood perfusion analysis in hind limb. However, this therapeutic regimen for ischemic limb using ADRCs did not affect remote melanoma growth nor the density of its feeder artery, angiogenesis, and lymphatic vessels compared with the PBS group. In addition, no distant metastases were detected in any of the mice regardless of the group. In conclusion, local implantation of ADRCs promotes angiogenesis in response to tissue ischemia in the hindlimb without promoting remote tumor growth and related angio/lymphangiogenesis. Therapeutic angiogenesis to the ischemic hindlimb using ADRCs seems to be safe regarding remote tumor growth.

    DOI: 10.1152/ajpheart.00564.2020

    Web of Science



  3. Alteration in ventricular pressure stimulates cardiac repair and remodeling.

    Kazumasa Unno, Angelos Oikonomopoulos, Yusuke Fujikawa, Yusuke Okuno, Singo Narita, Tomohiro Kato, Ryo Hayashida, Kazuhisa Kondo, Rei Shibata, Toyoaki Murohara, Yanfei Yang, Seema Dangwal, Konstantina-Ioanna Sereti, Qiu Yiling, Kory Johnson, Alokkumar Jha, David E Sosnovik, Yang Fann, Ronglih Liao.

    Journal of Molecular and Cellular Cardiology     2019.6

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  4. Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury.

    1. Naoya Otaka, Rei Shibata, Koji Ohashi, Yusuke Uemura, Takahiro Kambara, Takashi Enomoto, Hayato Ogawa, Masanori Ito, Hiroshi Kawanishi, Sonomi Maruyama, Yusuke Joki, Yusuke Fujikawa, Shingo Narita, Kazumasa Unno, Yoshiyuki Kawamoto, Takashi Murate, Toyoaki Murohara, Noriyuki Ouchi.

    Circulation Research     2018.12

Presentations 1

  1. Identification of critical six transcriptional factors for reprogramming of mouse adipose-derived regenerative cells toward cardiomyocytes and its therapeutic effect International conference

    Shingo Narita, Kazumasa Unno, Rei Shibata, Kazuhisa Kondo, Yuuki Shimizu, Katsuhiro Kato, Yusuke Fujikawa, Toyoaki Murohara

    American Heart Association Scientific Sessions 2021  2021.11.13  American Heart Association

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    Event date: 2021.11

    Language:English   Presentation type:Poster presentation  

    Venue:Boston, MA   Country:United States