Faculty Profiles - TORII Yuka

Papers - TORII Yuka

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Single-cell transcriptomics reveal heat shock protein dysregulation in severe SARS-CoV-2-associated pediatric encephalopathy Invited Reviewed Open Access

2026.3

Survey of Attitudes Toward Vaccination Against SARS-COV-2 in Pediatric Patients with Heart Disease Invited Reviewed

Yanagisawa, A. Torii, Y. Go, K. Kawada, J. I. Narita, A. Goto, A. Enomoto, S. Nishinosono, T. Yamaguchi, K. Kidokoro, H. Sato, Y. Takahashi, Y.

Pediatr Cardiol 2026.2

Association Between Adeno-associated Virus 2 and Neurologic Complications of Pediatric Human Herpesvirus-6B Infection

Jun-ichi Kawada, Yuki Higashimoto, Yoshiki Kawamura, Fumihiko Hattori, Mao Ite, Yuna Kawasaki, Hiroki Miura, Ken-ichi Iwata, Yuka Torii, Tetsushi Yoshikawa

Pediatric Infectious Disease Journal Vol. 44 ( 12 ) page： 1231 - 1236 2025.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

Background:

Recent studies have reported the possible link between adeno-associated virus 2 (AAV2) and severe pediatric acute hepatitis. It has been suggested that aberrant AAV2 replication initiated by coinfection with “helper viruses” such as human adenovirus and human herpesvirus-6B (HHV-6B) may induce abnormal immune responses. Encephalitis/encephalopathy is a severe complication of primary HHV-6B infection, but the underlying mechanisms remain unclear. This study analyzed the association between AAV2 coinfection and neurologic complications of primary HHV-6B infection in children.

Methods:

Preserved serum samples obtained from 36 patients with HHV-6B-associated encephalitis/encephalopathy, 39 with febrile seizure, and 83 without neurologic complications were retrospectively analyzed. Primary HHV-6B infection was confirmed if HHV-6B DNA was detected and the HHV-6B antibody was negative in serum. AAV2 and HHV-6 DNA loads were quantitated using real-time PCR.

Results:

AAV2 was detected in 4 (11%) and 3 (8%) patients in the encephalitis/encephalopathy and febrile seizure groups, respectively. In contrast, AAV2 was undetectable in 83 patients without neurologic complications. AAV2 detection frequency was significantly higher in the encephalitis/encephalopathy and febrile seizure groups compared with the no neurologic complications group (P = 0.01 and P = 0.03, respectively). Among 4 patients with HHV-6B-associated encephalitis/encephalopathy, AAV2 DNA was detected in the cerebrospinal fluid of 2 patients. Serum HHV-6B DNA load was not significantly different among patients who were AAV2 positive or AAV negative and with or without neurologic complications.

Conclusions:

These findings suggest that coinfection of AAV2 and HHV-6B is associated with neurologic complications such as encephalitis/encephalopathy and febrile seizure in children.

DOI： 10.1097/INF.0000000000004924

Associations of Nucleoside Diphosphate-Linked Moiety X-Type Motif 15 Variants With Neutropenia During Antiviral Therapy for Cytomegalovirus Disease in Pediatric Liver Transplant Recipients Reviewed Open Access

Iwata, K; Torii, Y; Fukuda, Y; Haruta, K; Yamaguchi, M; Suzuki, T; Ogura, Y; Kawada, J

TRANSPLANT INFECTIOUS DISEASE Vol. 27 ( 5 ) page： e70079 2025.9

Authorship：Corresponding author Language：English Publisher：Transplant Infectious Disease

Background: Cytomegalovirus (CMV) infection in pediatric liver transplant recipients is a major concern. Ganciclovir (GCV) and valganciclovir (VGCV) are the first-line treatment agents; however, neutropenia is a common adverse effect. Nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants are linked to thiopurine-induced myelosuppression; however, their associations with GCV/VGCV-induced cytotoxicity remain unclear. We aimed to examine the association between loss-of-function variants of the NUDT15 genotype and drug-related adverse reactions in pediatric transplant recipients, specifically liver transplant recipients, treated with GCV/VGCV. Methods: We retrospectively analyzed data from pediatric liver transplant recipients treated with GCV/VGCV for CMV disease or infection between 2012 and 2022. Patients were genotyped for NUDT15 R139C, R139H, and V18I variants, and hematological outcomes were compared between the normal and variant groups. Results: Of 40 patients, 10 (25%) harbored NUDT15 variants. The incidence rate of neutropenia (60% vs. 7%; p < 0.01) and percentage decrease in neutrophil count (−65.1% vs. −45.9%; p = 0.02) were significantly higher in the variant group than in the normal group. No significant differences were observed in the incidence of leukopenia, anemia, thrombocytopenia, hepatic toxicity, or renal toxicity. Conclusion: NUDT15 variants were associated with an increased risk of neutropenia in pediatric liver transplant recipients receiving GCV/VGCV treatment. Genetic screening before treatment initiation may help optimize antiviral therapy, minimize hematological toxicity, and improve patient management. Further studies are needed to refine the treatment strategies. (Figure presented.).

DOI： 10.1111/tid.70079

ヒトヘルペスウイルス6B初感染の中枢神経合併症とアデノ随伴ウイルス2の関連の検討

川田潤一, 東本祐紀, 河村吉紀, 服部文彦, 三浦浩樹, 岩田健一, 鳥居ゆか, 吉川哲史

臨床とウイルス Vol. 53 ( 3 ) page： 191 - 191 2025.9

Plasma Proteomic Profiles of Pediatric Patients With Human Herpesvirus 6B Encephalitis Following Umbilical Cord Blood Transplantation Open Access

Kazunori Haruta, Yuto Fukuda, Hisateru Yamaguchi, Yoshiki Kawamura, Takako Suzuki, Yuka Torii, Atsushi Narita, Hideki Muramatsu, Hiroyuki Kidokoro, Jun Natsume, Yoshiyuki Takahashi, Tetsushi Yoshikawa, Jun‐ichi Kawada

Journal of Medical Virology Vol. 97 ( 3 ) page： e70311 2025.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

ABSTRACT

Human herpesvirus 6B (HHV‐6B) encephalitis is a rare but severe complication of hematopoietic cell transplantation. This study investigated the pathogenesis of HHV‐6B encephalitis by comparing plasma proteomic profiles of four pediatric patients with HHV‐6B encephalitis to three with asymptomatic HHV‐6B reactivation following umbilical cord blood transplantation (UCBT). Plasma proteomic profiling was conducted using liquid chromatography‐mass spectrometry. Overall, 260 proteins were identified and quantified in plasma samples. At the onset of HHV‐6B encephalitis and asymptomatic reactivation, 20 and 24 proteins, respectively, were significantly upregulated compared to their respective pre‐onset levels. Of these, 11 proteins were uniquely upregulated in HHV‐6B encephalitis. S100‐A9 and S100‐A8 were the most and second‐most upregulated proteins in HHV‐6B encephalitis, respectively. Elevated plasma S100A8/A9 heterodimer levels were confirmed via enzyme‐linked immunosorbent assay in three of the four patients with HHV‐6B encephalitis. Pathway analysis identified neutrophil degranulation as the most enriched category among upregulated proteins in HHV‐6B encephalitis. Additionally, proteins related to the protein‐lipid complex remodeling pathway were more prominently upregulated in HHV‐6B encephalitis than in asymptomatic reactivation. Proteomic analysis revealed distinct plasma protein profiles between HHV‐6B encephalitis and asymptomatic HHV‐6B reactivation in pediatric UCBT recipients. The inflammatory response mediated by S100A8/A9 proteins may play a critical role in the pathogenesis of HHV‐6B encephalitis. These findings indicate that proteomic analysis may provide novel insights into the host response to HHV‐6B reactivation and the subsequent development of HHV‐6B encephalitis.

DOI： 10.1002/jmv.70311

Metagenomic Analysis of Lung Microbiome in Patients With Interstitial Lung Diseases and Sarcoidosis: An Experimental Study Open Access

Suguru Takeuchi, Jun‐ichi Kawada, Atsushi Suzuki, Koji Sakamoto, Yuto Fukuda, Kazuhiro Horiba, Takako Suzuki, Yuka Torii, Yuichiro Shindo, Yoshinori Ito

Health Science Reports Vol. 8 ( 2 ) page： e70328 2025.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

ABSTRACT

Background and Aims

Interactions between the lung microbiome and pulmonary epithelium plays a pivotal role in shaping immunity in the lung. Idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease (ILD). Some patients with IPF develop episodic acute exacerbations often associated with microbial dysbiosis in the lungs. This study aimed to investigate etiologic agents as well as the lung microbiome in patients with ILDs and sarcoidosis.

Methods

This study analyzed 31 patients divided into the IPF (IPF‐stable, n = 12), acute exacerbation of ILDs (AE‐ILDs, n = 6), and sarcoidosis (n = 13) groups. Bronchoalveolar lavage fluid (BALF) samples were analyzed by RNA‐based metagenomic next‐generation sequencing (NGS) on an Illumina platform.

Results

In total, 87 pathogens were detected using metagenomic NGS at the genus level. Prevotella, Streptococcus, and Veillonella dominated the BALF microbial communities, and sequence reads of these bacteria were abundant, especially in the sarcoidosis group. Conversely, only a small number of bacterial reads were detected in the AE‐ILDs group, and the overall proportion of microbial composition differed from that of the other groups. No significant difference was found in community diversity (α‐diversity) among the groups, whereas the structural similarity of the microflora (β‐diversity) differed significantly between the AE‐ILDs and sarcoidosis groups.

Conclusions

Bacterial sequence reads in BALF were smaller in both the IPF‐stable and AE‐ILD groups than in the sarcoidosis group. Dysbiosis in the lung microbiome has been observed in patients with AE‐ILD and may be related to the progression of inflammation.

DOI： 10.1002/hsr2.70328

Association between adeno-associated virus 2 and severe acute hepatitis of unknown etiology in Japanese children.

Iwata KI, Torii Y, Sakai A, Fukuda Y, Haruta K, Yamaguchi M, Suzuki T, Etani Y, Takahashi Y, Umetsu S, Inui A, Sumazaki R, Kawada JI

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy Vol. 31 ( 1 ) page： 102462 2025.1

The landscape of 142 Epstein-Barr viral whole genomes in gastric cancer

Kojima, Y; Hamada, M; Naruse, A; Goto, K; Khine, HT; Arai, H; Akutsu, Y; Satou, A; Nakaguro, M; Kato, S; Kodera, Y; Yatabe, Y; Torii, Y; Kawada, JI; Murata, T; Kimura, H; Takiguchi, S; Inagaki, H; Kataoka, H; Okuno, Y

JOURNAL OF GASTROENTEROLOGY Vol. 60 ( 1 ) page： 55 - 65 2025.1

Successful treatment of rapidly progressive Epstein-Barr virus-associated lymphoproliferative disorder with upfront allogeneic hematopoietic cell transplantation

YAE Hidekatsu, NISHIMOTO Mitsutaka, KAWAZOE Mai, TORII Yuka, KAWADA Jun-ichi, KUNO Masatomo, OKAMURA Hiroshi, NAKASHIMA Yasuhiro, NAKAMAE Mika, HINO Masayuki, NAKAMAE Hirohisa

Rinsho Ketsueki Vol. 66 ( 10 ) page： 1293 - 1297 2025

Authorship：Lead author Language：Japanese Publisher：The Japanese Society of Hematology

A 54-year-old woman presented with a chief concern of right back pain that had persisted for 3 weeks. Laboratory tests revealed pancytopenia, liver dysfunction, and coagulation abnormalities. She had hepatomegaly and splenomegaly but no lymphadenopathy. No abnormal cells were detected in the bone marrow or on a liver biopsy. Epstein-Barr virus (EBV) DNA levels in the peripheral blood were high at 6.44 log IU/ml, and clonality of EBV-infected cells was confirmed by Southern blot hybridization with a probe targeting the EBV terminal repeat. EBV-infected NK cells were detected using the magnetic bead method. This led to a diagnosis of EBV-associated lymphoproliferative disease (EBV-LPD). As pancytopenia and coagulation abnormalities induced by the development of hemophagocytic syndrome continued to worsen after steroid therapy, we performed intensive chemotherapy followed by umbilical cord blood transplantation. After transplantation, EBV-DNA levels in the peripheral blood were undetectable, with complete donor chimerism. In the present case, the rapid disease progression with an extremely high EBV-DNA level indicated a poor prognosis. Intensive chemotherapy followed by upfront allogeneic hematopoietic cell transplantation may be necessary in patients with rapidly progressing EBV-LPD.

DOI： 10.11406/rinketsu.66.1293

PubMed

CiNii Research

次世代シークエンサーを用いた血球貪食性リンパ組織球症の病原体診断

福田悠人, 堀場千尋, 岩田健一, 山口慎, 鈴木高子, 河邉慎司, 鳥居ゆか, 川田潤一

臨床とウイルス Vol. 52 ( 3 ) page： 130 - 130 2024.10

Serum proteomic profiles of patients with chronic recurrent multifocal osteomyelitis

Kawada, J; Yamaguchi, M; Haruta, K; Fukuda, Y; Iwata, K; Suzuki, T; Torii, Y

RHEUMATOLOGY 2024.6

Nanopore sequencing in distinguishing between wild-type and vaccine strains of Varicella-Zoster virus

Fukuda, Y; Suzuki, T; Iwata, KI; Haruta, K; Yamaguchi, M; Torii, Y; Narita, A; Muramatsu, H; Takahashi, Y; Kawada, JI

VACCINE Vol. 42 ( 11 ) page： 2927 - 2932 2024.4

Single-Cell Transcriptomic Analysis of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

Suzuki, T; Sato, Y; Okuno, Y; Torii, Y; Fukuda, Y; Haruta, K; Yamaguchi, M; Kawamura, Y; Hama, A; Narita, A; Muramatsu, H; Yoshikawa, T; Takahashi, Y; Kimura, H; Ito, Y; Kawada, JI

JOURNAL OF CLINICAL IMMUNOLOGY Vol. 44 ( 4 ) page： 103 2024.4

MicroRNA expression profiling of urine exosomes in children with congenital cytomegalovirus infection

Torii, Y; Suzuki, T; Fukuda, Y; Haruta, K; Yamaguchi, M; Horiba, K; Kawada, JI; Ito, Y

SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 5475 2024.3

Comparison of Whole Blood and Plasma for Monitoring Cytomegalovirus and Epstein-Barr Virus

Fukuda, Y; Torii, Y; Iwata, K; Haruta, K; Yamaguchi, M; Suzuki, T; Narita, A; Muramatsu, H; Ogura, Y; Takahashi, Y; Ito, Y; Kawada, J

NEW MICROBIOLOGICA Vol. 47 ( 1 ) 2024.3

Comparison of plasma proteomic profiles of patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis and infectious mononucleosis

Haruta, K; Suzuki, T; Yamaguchi, M; Fukuda, Y; Torii, Y; Takahashi, Y; Ito, Y; Kawada, J

JOURNAL OF MEDICAL VIROLOGY Vol. 96 ( 2 ) page： e29450 2024.2

Next-generation sequencing-based detection of Ureaplasma in the gastric fluid of neonates with respiratory distress and chorioamnionitis Open Access

Okumura, T; Horiba, K; Tetsuka, N; Sato, Y; Sugiyama, Y; Haruta, K; Yamaguchi, M; Suzuki, T; Torii, Y; Kawada, J; Ogi, T; Hayakawa, M; Ito, Y

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE Vol. 36 ( 1 ) page： 2207113 2023.12

特集エキスパートが教える小児の薬物治療 Ⅲ.疾患別 B.感染症サイトメガロウイルス感染症

鳥居ゆか, 川田潤一

小児内科 Vol. 55 ( 13 ) page： 300 - 304 2023.11

Proteomic Analysis Reveals Novel Plasma Biomarkers for Neurological Complications in Patients With Congenital Cytomegalovirus Infection

Yamaguchi, M; Suzuki, T; Kidokoro, H; Iwata, K; Fukuda, Y; Haruta, K; Torii, Y; Ito, Y; Kawada, J

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY Vol. 12 ( 10 ) page： 525 - 533 2023.10

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Papers - TORII Yuka