2022/11/06 更新

写真a

カトウ ヒデカズ
加藤 秀一
KATO Hidekazu
所属
医学部附属病院 親と子どもの心療科 助教
大学院担当
大学院医学系研究科
職名
助教

学位 1

  1. 博士(医学) ( 2021年3月   名古屋大学 ) 

現在の研究課題とSDGs 1

  1. 精神障害をもつ患者でのヒストンメチル化修飾の調節障害

学歴 2

  1. 名古屋大学   大学院   医学系研究科

    - 2021年3月

  2. 富山大学   医学部   医学科

    - 2007年3月

受賞 1

  1. 国際学会発表賞

    2016年   日本精神神経学会  

 

論文 12

  1. Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes 査読有り

    Hiroki Kimura, Masahiro Nakatochi, Branko Aleksic, James Guevara, Miho Toyama, Yu Hayashi, Hidekazu Kato, Itaru Kushima, Mako Morikawa, Kanako Ishizuka, Takashi Okada, Yoshinori Tsurusaki, Atsushi Fujita, Noriko Miyake, Tomoo Ogi, Atsushi Takata, Naomichi Matsumoto, Joseph Buxbaum, Norio Ozaki, Jonathan Sebat

    Translational Psychiatry   12 巻 ( 1 )   2022年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Autism spectrum disorder (ASD) is a highly heritable, complex disorder in which rare variants contribute significantly to disease risk. Although many genes have been associated with ASD, there have been few genetic studies of ASD in the Japanese population. In whole exomes from a Japanese ASD sample of 309 cases and 299 controls, rare variants were associated with ASD within specific neurodevelopmental gene sets, including highly constrained genes, fragile X mental retardation protein target genes, and genes involved in synaptic function, with the strongest enrichment in trans-synaptic signaling (p = 4.4 × 10<sup>−4</sup>, Q-value = 0.06). In particular, we strengthen the evidence regarding the role of ABCA13, a synaptic function-related gene, in Japanese ASD. The overall results of this case-control exome study showed that rare variants related to synaptic function are associated with ASD susceptibility in the Japanese population.

    DOI: 10.1038/s41398-022-02033-6

    その他リンク: https://www.nature.com/articles/s41398-022-02033-6

  2. The genetic architecture of schizophrenia: review of large-scale genetic studies 査読有り

    Hidekazu Kato, Hiroki Kimura, Itaru Kushima, Nagahide Takahashi, Branko Aleksic, Norio Ozaki

    Journal of Human Genetics     2022年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media {LLC}  

    DOI: 10.1038/s10038-022-01059-4

    その他リンク: https://www.nature.com/articles/s10038-022-01059-4

  3. Contribution of copy number variations to the risk of severe eating disorders 査読有り

    Itaru Kushima, Miho Imaeda, Satoshi Tanaka, Hidekazu Kato, Tomoko Oya‐Ito, Masahiro Nakatochi, Branko Aleksic, Norio Ozaki

    Psychiatry and Clinical Neurosciences     2022年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/pcn.13430

    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13430

  4. Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels 査読有り

    Miho Toyama, Regie Lyn Pastor Santos-Cortez, Yuto Takasaki, Aleksic Branko, Hiroki Kimura, Hidekazu Kato, Yoshihiro Nawa, Itaru Kushima, Kanako Ishizuka, Teppei Shimamura, Tomoo Ogi, Norio Ozaki

    PLOS ONE   17 巻 ( 5 ) 頁: e0268321 - e0268321   2022年5月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Public Library of Science (PLoS)  

    Background

    Most sequencing studies of schizophrenia (SCZ) have focused on de novo genetic variants due to interpretability. However, investigating shared rare variants among patients in the same multiplex family is also important. Relatively large-scale analyses of SCZ multiplex families have been done in Caucasian populations, but whether detected variants are also pathogenic in the Japanese population is unclear because of ethnic differences in rare variants.

    Materials and methods

    We performed whole-exome sequencing (WES) of 14 Japanese SCZ multiplex families. After quality control and filtering, we identified rare variants shared among affected persons within the same family. A gene ontology (GO) analysis was performed to identify gene categories possibly affected by these candidate variants.

    Results

    We found 530 variants in 486 genes as potential candidate variants from the 14 SCZ multiplex families examined. The GO analysis demonstrated significant enrichment in calcium channel activity.

    Conclusion

    This study provides supporting evidence that calcium ion channel activity is involved in SCZ. WES of multiplex families is a potential means of identifying disease-associated rare variants for SCZ.

    DOI: 10.1371/journal.pone.0268321

  5. Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder. 査読有り

    Sho Furuta, Branko Aleksic, Yoshihiro Nawa, Hiroki Kimura, Itaru Kushima, Kanako Ishizuka, Hidekazu Kato, Miho Toyama, Yuko Arioka, Daisuke Mori, Mako Morikawa, Toshiya Inada, Norio Ozaki

    Nagoya journal of medical science   84 巻 ( 2 ) 頁: 260 - 268   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A number of genomic mutations that are thought to be strongly involved in the development of schizophrenia (SCZ) and autism spectrum disorder (ASD) have been identified. Abnormalities involving oligodendrocytes have been reported in SCZ, and as a related gene, oligodendrocyte lineage transcription factor 2 (OLIG2) has been reported to be strongly associated with SCZ. In this study, based on the common disease-rare variant hypothesis, target sequencing of candidate genes was performed to identify rare mutations with a high effect size and the possibility that the identified mutations may increase the risks of SCZ and ASD in the Japanese population. In this study, the exon region of OLIG2 was targeted; 370 patients with SCZ and 192 with ASD were subjected to next-generation sequencing. As a result, one rare missense mutation (A33T) was detected. We used the Sanger method to validate this missense mutation with a low frequency (<1%), and then carried out a genetic association analysis involving 3299 unrelated individuals (1447 with SCZ, 380 with ASD, and 1472 healthy controls) to clarify whether A33T was associated with SCZ or ASD. A33T was not found in either case group, and in only one control. We did not find evidence that p.A33T is involved in the onset of ASD or SCZ; however, associations with this variant need to be evaluated in larger samples to confirm our results.

    DOI: 10.18999/nagjms.84.2.260

    PubMed

  6. Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder 査読有り 国際誌

    Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki

    Biological Psychiatry   92 巻 ( 5 ) 頁: 362 - 374   2022年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: We aimed to determine the similarities and differences in the roles of genic and regulatory copy number variations (CNVs) in bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD). METHODS: Based on high-resolution CNV data from 8708 Japanese samples, we performed to our knowledge the largest cross-disorder analysis of genic and regulatory CNVs in BD, SCZ, and ASD. RESULTS: In genic CNVs, we found an increased burden of smaller (<100 kb) exonic deletions in BD, which contrasted with the highest burden of larger (>500 kb) exonic CNVs in SCZ/ASD. Pathogenic CNVs linked to neurodevelopmental disorders were significantly associated with the risk for each disorder, but BD and SCZ/ASD differed in terms of the effect size (smaller in BD) and subtype distribution of CNVs linked to neurodevelopmental disorders. We identified 3 synaptic genes (DLG2, PCDH15, and ASTN2) as risk factors for BD. Whereas gene set analysis showed that BD-associated pathways were restricted to chromatin biology, SCZ and ASD involved more extensive and similar pathways. Nevertheless, a correlation analysis of gene set results indicated weak but significant pathway similarities between BD and SCZ or ASD (r = 0.25-0.31). In SCZ and ASD, but not BD, CNVs were significantly enriched in enhancers and promoters in brain tissue. CONCLUSIONS: BD and SCZ/ASD differ in terms of CNV burden, characteristics of CNVs linked to neurodevelopmental disorders, and regulatory CNVs. On the other hand, they have shared molecular mechanisms, including chromatin biology. The BD risk genes identified here could provide insight into the pathogenesis of BD.

    DOI: 10.1016/j.biopsych.2022.04.003

    PubMed

  7. Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population 査読有り

    Tzuyao Lo, Itaru Kushima, Branko Aleksic, Hidekazu Kato, Yoshihiro Nawa, Yu Hayashi, Gantsooj Otgonbayar, Hiroki Kimura, Yuko Arioka, Daisuke Mori, Norio Ozaki

    International Review of Psychiatry   34 巻 ( 2 ) 頁: 154 - 167   2022年2月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Informa UK Limited  

    DOI: 10.1080/09540261.2022.2072193

  8. Autism Spectrum Disorder Comorbid with Obsessive Compulsive Disorder and Eating Disorder in a Woman with NBEA Deletion 査読有り

    Hidekazu Kato, Itaru Kuhisma, Akira Yoshimi, Kanako Ishizuka, Hiroki Kimura, Branko Aleksic, Nagahide Takahashi, Takashi Okada, Norio Ozaki

    Psychiatry and Clinical Neurosciences   76 巻 ( 1 ) 頁: 36 - 38   2022年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/pcn.13309

  9. Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility 査読有り 国際誌

    Yoshihiro Nawa, Hiroki Kimura, Daisuke Mori, Hidekazu Kato, Miho Toyama, Sho Furuta, Yanjie Yu, Kanako Ishizuka, Itaru Kushima, Branko Aleksic, Yuko Arioka, Mako Morikawa, Takashi Okada, Toshiya Inada, Kozo Kaibuchi, Masashi Ikeda, Nakao Iwata, Michio Suzuki, Yuko Okahisa, Jun Egawa, Toshiyuki Someya, Fumichika Nishimura, Tsukasa Sasaki, Norio Ozaki

    Human Genome Variation   7 巻 ( 1 ) 頁: 37 - 37   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Disabled 1 (DAB1) is an intracellular adaptor protein in the Reelin signaling pathway and plays an essential role in correct neuronal migration and layer formation in the developing brain. DAB1 has been repeatedly reported to be associated with neurodevelopmental disorders including schizophrenia (SCZ) and autism spectrum disorders (ASD) in genetic, animal, and postmortem studies. Recently, increasing attention has been given to rare single-nucleotide variants (SNVs) found by deep sequencing of candidate genes. In this study, we performed exon-targeted resequencing of DAB1 in 370 SCZ and 192 ASD patients using next-generation sequencing technology to identify rare SNVs with a minor allele frequency <1%. We detected two rare missense mutations (G382C, V129I) and then performed a genetic association study in a sample comprising 1763 SCZ, 380 ASD, and 2190 healthy control subjects. Although no statistically significant association with the detected mutations was observed for either SCZ or ASD, G382C was found only in the case group, and in silico analyses and in vitro functional assays suggested that G382C alters the function of the DAB1 protein. The rare variants of DAB1 found in the present study should be studied further to elucidate their potential functional relevance to the pathophysiology of SCZ and ASD.

    DOI: 10.1038/s41439-020-00125-7

    PubMed

  10. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk 査読有り

    Mariko Sekiguchi, Akira Sobue, Itaru Kushima, Chenyao Wang, Yuko Arioka, Hidekazu Kato, Akiko Kodama, Hisako Kubo, Norimichi Ito, Masahito Sawahata, Kazuhiro Hada, Ryosuke Ikeda, Mio Shinno, Chikara Mizukoshi, Keita Tsujimura, Akira Yoshimi, Kanako Ishizuka, Yuto Takasaki, Hiroki Kimura, Jingrui Xing, Yanjie Yu, Maeri Yamamoto, Takashi Okada, Emiko Shishido, Toshiya Inada, Masahiro Nakatochi, Tetsuya Takano, Keisuke Kuroda, Mutsuki Amano, Branko Aleksic, Takashi Yamomoto, Tetsushi Sakuma, Tomomi Aida, Kohichi Tanaka, Ryota Hashimoto, Makoto Arai, Masashi Ikeda, Nakao Iwata, Teppei Shimamura, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Kiyofumi Yamada, Daisuke Mori, Norio Ozaki

    Translational Psychiatry   10 巻 ( 1 ) 頁: 247   2020年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media {LLC}  

    © 2020, The Author(s). Schizophrenia (SCZ) is known to be a heritable disorder; however, its multifactorial nature has significantly hampered attempts to establish its pathogenesis. Therefore, in this study, we performed genome-wide copy-number variation (CNV) analysis of 2940 patients with SCZ and 2402 control subjects and identified a statistically significant association between SCZ and exonic CNVs in the ARHGAP10 gene. ARHGAP10 encodes a member of the RhoGAP superfamily of proteins that is involved in small GTPase signaling. This signaling pathway is one of the SCZ-associated pathways and may contribute to neural development and function. However, the ARHGAP10 gene is often confused with ARHGAP21, thus, the significance of ARHGAP10 in the molecular pathology of SCZ, including the expression profile of the ARHGAP10 protein, remains poorly understood. To address this issue, we focused on one patient identified to have both an exonic deletion and a missense variant (p.S490P) in ARHGAP10. The missense variant was found to be located in the RhoGAP domain and was determined to be relevant to the association between ARHGAP10 and the active form of RhoA. We evaluated ARHGAP10 protein expression in the brains of reporter mice and generated a mouse model to mimic the patient case. The model exhibited abnormal emotional behaviors, along with reduced spine density in the medial prefrontal cortex (mPFC). In addition, primary cultured neurons prepared from the mouse model brain exhibited immature neurites in vitro. Furthermore, we established induced pluripotent stem cells (iPSCs) from this patient, and differentiated them into tyrosine hydroxylase (TH)-positive neurons in order to analyze their morphological phenotypes. TH-positive neurons differentiated from the patient-derived iPSCs exhibited severe defects in both neurite length and branch number; these defects were restored by the addition of the Rho-kinase inhibitor, Y-27632. Collectively, our findings suggest that rare ARHGAP10 variants may be genetically and biologically associated with SCZ and indicate that Rho signaling represents a promising drug discovery target for SCZ treatment.

    DOI: 10.1038/s41398-020-00917-z

    Scopus

    PubMed

  11. Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder 査読有り

    Hidekazu Kato, Itaru Kushima, Daisuke Mori, Akira Yoshimi, Branko Aleksic, Yoshihiro Nawa, Miho Toyama, Sho Furuta, Yanjie Yu, Kanako Ishizuka, Hiroki Kimura, Yuko Arioka, Keita Tsujimura, Mako Morikawa, Takashi Okada, Toshiya Inada, Masahiro Nakatochi, Keiko Shinjo, Yutaka Kondo, Kozo Kaibuchi, Yasuko Funabiki, Ryo Kimura, Toshimitsu Suzuki, Kazuhiro Yamakawa, Masashi Ikeda, Nakao Iwata, Tsutomu Takahashi, Michio Suzuki, Yuko Okahisa, Manabu Takaki, Jun Egawa, Toshiyuki Someya, Norio Ozaki

    Translational Psychiatry   10 巻 ( 1 ) 頁: 421   2020年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    <title>Abstract</title>Dysregulation of epigenetic processes involving histone methylation induces neurodevelopmental impairments and has been implicated in schizophrenia (SCZ) and autism spectrum disorder (ASD). Variants in the gene encoding lysine demethylase 4C (<italic>KDM4C</italic>) have been suggested to confer a risk for such disorders. However, rare genetic variants in <italic>KDM4C</italic> have not been fully evaluated, and the functional impact of the variants has not been studied using patient-derived cells. In this study, we conducted copy number variant (CNV) analysis in a Japanese sample set (2605 SCZ and 1141 ASD cases, and 2310 controls). We found evidence for significant associations between CNVs in <italic>KDM4C</italic> and SCZ (<italic>p</italic> = 0.003) and ASD (<italic>p</italic> = 0.04). We also observed a significant association between deletions in <italic>KDM4C</italic> and SCZ (corrected <italic>p</italic> = 0.04). Next, to explore the contribution of single nucleotide variants in <italic>KDM4C</italic>, we sequenced the coding exons in a second sample set (370 SCZ and 192 ASD cases) and detected 18 rare missense variants, including p.D160N within the JmjC domain of KDM4C. We, then, performed association analysis for p.D160N in a third sample set (1751 SCZ and 377 ASD cases, and 2276 controls), but did not find a statistical association with these disorders. Immunoblotting analysis using lymphoblastoid cell lines from a case with <italic>KDM4C</italic> deletion revealed reduced KDM4C protein expression and altered histone methylation patterns. In conclusion, this study strengthens the evidence for associations between <italic>KDM4C</italic> CNVs and these two disorders and for their potential functional effect on histone methylation patterns.

    DOI: 10.1038/s41398-020-01107-7

    その他リンク: http://www.nature.com/articles/s41398-020-01107-7

  12. Urine screening for patients with developmental disabilities detected a patient with creatine transporter deficiency due to a novel missense mutation in SLC6A8 査読有り

    Hidekazu Kato, Fuyu Miyake, Hiroko Shimbo, Makoto Ohya, Hidenori Sugawara, Noriko Aida, Rie Anzai, Mariko Takagi, Mitsuko Okuda, Kyoko Takano, Takahito Wada, Mizue Iai, Sumimasa Yamashita, Hitoshi Osaka

    Brain and Development   36 巻 ( 7 ) 頁: 630 - 633   2014年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier {BV}  

    DOI: 10.1016/j.braindev.2013.08.004

▼全件表示

MISC 13

  1. 「発達障がい」とはー診断概念の変遷に注目してー

    加藤秀一, 尾崎紀夫  

    CLINICAL NEUROSCIENCE40 巻 ( 3 ) 頁: 290 - 294   2022年3月

  2. 多施設共同研究とゲノム情報の集約により精神疾患の病態解明から根本的治療薬開発へ

    加藤秀一, 尾崎紀夫  

    日本生物学的精神医学会誌32 巻 ( 2 ) 頁: 89 - 93   2021年6月

  3. 自閉スペクトラム症ゲノム解析の現状-当事者・家族の期待に応える成果を目指して-

    加藤秀一, 有岡祐子, 尾崎紀夫  

    児童青年精神医学とその近接領域62 巻 ( 4 ) 頁: 440 - 445   2021年

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  4. Challenges and opportunities for early career child mental health professionals during the COVID19 pandemic 査読有り

    Sundar Gnanavel, Tanay Maiti, Pawan Sharma, Darpan Kaur, Fransiska Kaligis, Jane Pei-Chen Chang, Hidekazu Kato, Asilay Seker, Dmytro Martsenkovskyi, Massimiliano Orri, Sifat E. Syed, Evelyne Baroud, Muftau Mohammed, Julia Dray, Aarya K. Rajalakshmi, Dorottya Ori, Tze Jui Goh, Anna Sofie Hansen, Ana Munjiza, Alessia Delle Grottaglie  

    Asian Journal of Psychiatry54 巻   頁: 102443   2020年12月

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    出版者・発行元:Elsevier {BV}  

    DOI: 10.1016/j.ajp.2020.102443

  5. Child and adolescent psychiatry research during the COVID-19 pandemic 査読有り

    Sundar Gnanavel, Massimiliano Orri, Muftau Mohammed, Julia Dray, Evelyne Baroud, Hidekazu Kato, Goh Tze Jui, Aarya K Rajalakshmi, Anna Sofie Hansen, Asilay Seker, Dorottya Ori, Ana Munjiza, Dmytro Martsenkovskyi  

    The Lancet Psychiatry7 巻 ( 9 ) 頁: 735   2020年9月

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    出版者・発行元:Elsevier {BV}  

    DOI: 10.1016/s2215-0366(20)30314-x

  6. 【発達障害支援の現状と今後の方向性をめぐって】ASDをかかえる成人を対象としたショートケアプログラムの実際 愛知県精神医療センターでの実践

    中岡 健太郎, 加藤 秀一, 沢出 新吾, 原口 留里, 大村 豊  

    心と社会51 巻 ( 1 ) 頁: 31 - 36   2020年3月

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    記述言語:日本語   出版者・発行元:(公財)日本精神衛生会  

  7. Child and adolescent psychiatry training curriculum: a global trainee's perspective 査読有り

    Sundar Gnanavel, Pawan Sharma, Antonin Sebela, Teresa Gomez Alemany, Jane Pei-Chen Chang, Mauro Victor de Medeiros Filho, Kwabena Kusi-Mensah, Fransiska Kaligis, Hidekazu Kato, Huu Kim Le, Kana Morimoto, Dmytro Martsenkovskyi, Darpan Kaur Mohinder Singh, Aditya Pawar, Asilay Seker, Napat Sittanomai, Sifat-e Syed, Utkarsh Karki, Arpit Parmar, Marcus Tan  

    BJPsych International17 巻 ( 3 ) 頁: 69 - 71   2020年2月

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    出版者・発行元:Royal College of Psychiatrists  

    DOI: 10.1192/bji.2020.8

  8. 自閉スペクトラム症―診断上の留意点と,発症メカニズムの最近の知見について― 査読有り

    加藤 秀一, 尾崎 紀夫  

    臨床神経学59 巻 ( 1 ) 頁: 13 - 20   2019年1月

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  9. 【プライマリ・ケア医だからできる精神症状への関わりかた よりよい考え方、話の聴き方、向き合い方】発達障害の特性に配慮した身体診察のコツ 自閉スペクトラム症を中心に

    加藤 秀一, 増田 史, 長 徹二  

    Gノート4 巻 ( 8 ) 頁: 1402 - 1410   2017年12月

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    記述言語:日本語   出版者・発行元:(株)羊土社  

    <Point>●発達障害の特性を有する方の身体診療時には、本人、家族、そして医療者ともに困難を感じることが少なくない●本人の能力や特性に合わせた配慮をすることで、その困難は解消されることも多い●感覚過敏への対応、見通しをもちやすくするための対応、そして視覚認知の強さなどの強みを活かした対応などを意識するとよい●能力や特性の個人差は大きく、診察のしかたについて家族ともよく相談をするとよい(著者抄録)

  10. FOOD REPERTOIRE AND NUTRITIONAL DEFICIENCY IN JAPANESE CHILDREN WITH AUTISM SPECTRUM DISORDERS 査読有り

    TANOUE Koji, MINAMI Tatsuya, SYOU Noriko, FUJITA Junichi, TOYOHARA Koji, KATO Hidekazu, ARAI Takashi  

    児童青年精神医学とその近接領域58 巻 ( 3 ) 頁: 389 - 397   2017年6月

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    記述言語:日本語   出版者・発行元:日本児童青年精神医学会  

    DOI: 10.20615/jscap.58.3_389

    CiNii Books

  11. 児童精神科医からみた読書療法の可能性

    加藤 秀一  

    全国患者図書サービス連絡会会報21 巻 ( 4 ) 頁: 43 - 46   2015年7月

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    記述言語:日本語   出版者・発行元:全国患者図書サービス連絡会  

  12. 小児における末梢静脈ラインの間欠注入ロックに関する文献的考察 査読有り

    加藤 秀一, 松井 潔  

    こども医療センター医学誌41 巻 ( 3 ) 頁: 107 - 109   2012年7月

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    記述言語:日本語   出版者・発行元:神奈川県立こども医療センター  

    患児の安全と持続点滴の拘束から解放するため末梢静脈路の間欠注入ロックは有用である。その方法にはヘパリン生食によるロックと生理食塩水によるロックがある。当院では主にヘパリン生食が用いられているが、両者の利点と欠点について検討した。末梢静脈路の維持において、開通率や静脈炎の頻度は両者に差はないが、ヘパリンロックに比べ生食ロックは安全かつ経済的であると考えられた。ヘパリンロックに比べて生食ロックではルート内に血栓が作られやすいので右左シャントを持つ先天性心疾患の児ではヘパリンロックを用いた方が良いと考えられた。いずれの方法をとる際も陽圧をかけながらロックすることが重要である。(著者抄録)

  13. 新型インフルエンザ(A/H1N1)により急性呼吸障害を呈した18例の臨床的検討 査読有り

    加藤 秀一, 松井 潔, 林 拓也, 西村 洋子, 山本 敦子, 宮城 崇史, 甲賀 健史, 山本 亜矢子, 梅原 直  

    こども医療センター医学誌40 巻 ( 3 ) 頁: 191 - 195   2011年7月

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    記述言語:日本語   出版者・発行元:神奈川県立こども医療センター  

    2009年に大流行したパンデミックインフルエンザA(H1N1)の多くは軽症例であったが、急速に呼吸不全をきたす重症例がみられた。当センターでは3次医療機関として主に重症例の診療にあたった。今回、当科で経験した重症例の臨床像を明らかにするため、挿管群と非挿管群に分けて比較し、呼吸管理を要する児の危険因子を検討した。両群とも男児が多く、喘息の既往を持つ例が多かった。症状発現後、急速に呼吸不全に至ったが、治療開始後は両群とも比較的速やかに症状は改善したことから早期介入が重要であると考えられた。重症化の危険因子については、酸素化障害のみ重要な臨床指標であることが明らかとなった。他の予後因子を明らかにするには、軽症例と重症例を比較検討する必要がある。(著者抄録)

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講演・口頭発表等 7

  1. 頻回の自傷行為と解離・幻聴等精神症状を認めた性別違和の中学生の一例

    長崎由佳子, 加藤秀一, 高橋長秀, 尾崎紀夫

    愛知児童青年精神医学会第13回学術総会  2022年3月6日 

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    開催年月日: 2022年3月

    会議種別:口頭発表(一般)  

    開催地:名古屋   国名:日本国  

  2. 自閉スペクトラム症多発家系における遺伝カウンセリングを通じて父親の自責感が軽減した一例

    加藤 秀一, 石塚 佳奈子, 名和 佳弘, 木村 大樹, 久島 周, 高橋 長秀, 尾崎 紀夫

    第62回日本児童青年精神医学会総会  2021年11月 

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    開催年月日: 2021年11月

    会議種別:口頭発表(一般)  

    開催地:Web  

  3. 3q29欠失を有し統合失調症と診断された4症例の報告

    名和 佳弘, 久島 周, 加藤 秀一, 木村 大樹, 阪野 正大, 橋本 亮太, 菱本 明豊, 尾崎 紀夫

    第62回日本児童青年精神医学会総会  2021年11月 

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    開催年月日: 2021年11月

    会議種別:口頭発表(一般)  

    開催地:Web  

  4. The cooperation between child and adolescent psychiatry and education in Japan (Research symposium, Child and adolescent psychiatry and education in Asia)

    Hidekazu Kato

    The 23rd International Association for Child and Adolescent Psychiatry and Allied Professions World Congress (IACAPAP)  2018年7月 

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    開催年月日: 2018年7月

    会議種別:シンポジウム・ワークショップ パネル(公募)  

  5. Child and Adolescent Psychiatry: Overview of Training System and Update Situation in Asian Countries

    Hidekazu Kato, Li-Te Chiang, Nisarat Wadchareeudomkarn

    The 22nd International Association for Child and Adolescent Psychiatry and Allied Professions World Congress (IACAPAP)  2016年9月 

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    開催年月日: 2016年9月

    会議種別:口頭発表(一般)  

  6. The Training System and Challenges of Child and Adolescent Psychiatry (CAP): Perspective from Japan (WPAIC symposium, Child and Adolescent Psychiatry Training and Challenges in Asia)

    Hidekazu Kato

    WPA International Congress of Psychiatry  2015年11月 

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    開催年月日: 2015年11月

    会議種別:シンポジウム・ワークショップ パネル(公募)  

  7. “Hikikomori”: a form of social withdrawal related to Japanese culture (The 14th KJYPA symposium at KNPA Conference)

    Hidekazu Kato

    The 2013 Korean Neuro-Psychiatric Association (KNPA) meeting  2013年10月 

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    開催年月日: 2013年10月

    会議種別:シンポジウム・ワークショップ パネル(公募)  

▼全件表示

科研費 3

  1. 精神障害の病態としてのヒストンメチル化異常ー患者におけるゲノム変異を起点としてー

    研究課題/研究課題番号:22K15748  2022年4月 - 2025年3月

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    加藤 秀一

  2. 小児を対象とした精神疾患診断のためのコンピュータ式半構造化面接KASDS-COMP日本語版の開発

    2022年4月 - 2023年3月

    小児医学研究振興財団 

  3. 精神障害をもつ患者でのヒストンメチル化修飾の調節障害ーゲノム変異を起点としてー

    研究課題/研究課題番号:21K20866  2021年8月 - 2023年3月

    日本学術振興会  科学研究費助成事業 研究活動スタート支援  研究活動スタート支援

    加藤 秀一

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    担当区分:研究代表者 

    配分額:3120000円 ( 直接経費:2400000円 、 間接経費:720000円 )

 

担当経験のある科目 (本学) 1

  1. PBLチュートリアル

    2021

 

社会貢献活動 3

  1. 愛知県自閉症協会・つぼみの会 高機能部相談会

    役割:助言・指導

    愛知県自閉症協会・つぼみの会  2022年3月

  2. 愛知県自閉症協会・つぼみの会 ペアレントメンター研修

    役割:講師

    愛知県自閉症協会・つぼみの会  2022年1月

  3. 発達障害医療ネットワーク連絡協議会 構成員

    役割:運営参加・支援

    あいち発達障害者支援センター  2021年5月 - 現在