Updated on 2024/02/23

写真a

 
KATO Hidekazu
 
Organization
Nagoya University Hospital Psychiatry for Parents and Children Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor
External link

Degree 1

  1. 博士(医学) ( 2021.3   名古屋大学 ) 

Research Interests 3

  1. 児童思春期精神医学

  2. 遺伝カウンセリング

  3. 自閉スペクトラム症

Current Research Project and SDGs 1

  1. 精神障害をもつ患者でのヒストンメチル化修飾の調節障害

Education 2

  1. Nagoya University

    - 2021.3

  2. University of Toyama

    - 2007.3

Committee Memberships 1

  1. 日本児童青年精神医学会   生涯教育委員  

    2023   

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    Committee type:Academic society

Awards 2

  1. 国際学会発表奨励賞

    2023.11   日本児童青年精神医学会  

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  2. International Conference Presentation Award

    2016   Child and adolescent psychiatry: Overview of training system and update situation in Asian countries(The 22nd International Association for Child and Adolescent Psychiatry and Allied Professions World Congress)

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Papers 14

  1. Association between copy number variations in parkin (<i>PRKN</i>) and schizophrenia and autism spectrum disorder: A case–control study Reviewed

    Tzuyao Lo, Itaru Kushima, Hiroki Kimura, Branko Aleksic, Takashi Okada, Hidekazu Kato, Toshiya Inada, Yoshihiro Nawa, Youta Torii, Maeri Yamamoto, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Shusuke Numata, Kiyoto Kasai, Tsukasa Sasaki, Shigeru Yokoyama, Toshio Munesue, Ryota Hashimoto, Yuka Yasuda, Michiko Fujimoto, Masahide Usami, Masanari Itokawa, Makoto Arai, Kazutaka Ohi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Hidenori Yamasue, Nakao Iwata, Masashi Ikeda, Norio Ozaki

    Neuropsychopharmacology Reports     2023.11

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Aim

    The present study aimed to examine the association between copy number variations (CNVs) in parkin (PRKN) and schizophrenia (SCZ) and autism spectrum disorder (ASD) in a large case–control sample.

    Method

    Array comparative genomic hybridization was performed on 3111 cases with SCZ, 1236 cases with ASD, and 2713 controls. We systematically prioritized likely pathogenic CNVs (LP‐CNVs) in PRKN and examined their association with SCZ and ASD.

    Results

    In total, 3014 SCZ cases (96.9%), 1205 ASD cases (97.5%), and 2671 controls (98.5%) passed quality control. We found that monoallelic carriers of LP‐CNVs in PRKN were common (70/6890, 1.02%) and were not at higher risk of SCZ (p = 0.29) or ASD (p = 0.72). We observed that the distribution pattern of LP‐CNVs in the Japanese population was consistent with those in other populations. We also identified a patient diagnosed with SCZ and early‐onset Parkinson's disease carrying biallelic pathogenic CNVs in PRKN. The absence of Parkinson's symptoms in 10 other monoallelic carriers of the same pathogenic CNV further reflects the lack of effect of monoallelic pathogenic variants in PRKN in the absence of a second hit.

    Conclusion

    The present findings suggest that monoallelic CNVs in PRKN do not confer a significant risk for SCZ or ASD. However, further studies to investigate the association between biallelic CNVs in PRKN and SCZ and ASD are warranted.

    DOI: 10.1002/npr2.12370

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  2. Analysis of human neuronal cells carrying ASTN2 deletion: A cross-disorder risk variant of schizophrenia, autism spectrum disorder, and bipolar disorder Reviewed

    Yuko Arioka, Yu Hayashi, Hiroki Okumura, Itaru Kushima, Daisuke Mori, Tzuyao Lo, Gantsooj Otgonbayar, Hidekazu Kato, Yoshihiro Nawa, Hiroki Kimura, Branko Aleksic, Norio Ozaki

        2023.2

  3. Exome sequencing analysis of Japanese autism spectrum disorder case-control sample supports an increased burden of synaptic function-related genes Reviewed

    Hiroki Kimura, Masahiro Nakatochi, Branko Aleksic, James Guevara, Miho Toyama, Yu Hayashi, Hidekazu Kato, Itaru Kushima, Mako Morikawa, Kanako Ishizuka, Takashi Okada, Yoshinori Tsurusaki, Atsushi Fujita, Noriko Miyake, Tomoo Ogi, Atsushi Takata, Naomichi Matsumoto, Joseph Buxbaum, Norio Ozaki, Jonathan Sebat

    Translational Psychiatry   Vol. 12 ( 1 )   2022.12

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Autism spectrum disorder (ASD) is a highly heritable, complex disorder in which rare variants contribute significantly to disease risk. Although many genes have been associated with ASD, there have been few genetic studies of ASD in the Japanese population. In whole exomes from a Japanese ASD sample of 309 cases and 299 controls, rare variants were associated with ASD within specific neurodevelopmental gene sets, including highly constrained genes, fragile X mental retardation protein target genes, and genes involved in synaptic function, with the strongest enrichment in trans-synaptic signaling (p = 4.4 × 10<sup>−4</sup>, Q-value = 0.06). In particular, we strengthen the evidence regarding the role of ABCA13, a synaptic function-related gene, in Japanese ASD. The overall results of this case-control exome study showed that rare variants related to synaptic function are associated with ASD susceptibility in the Japanese population.

    DOI: 10.1038/s41398-022-02033-6

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    Other Link: https://www.nature.com/articles/s41398-022-02033-6

  4. Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder Reviewed International journal

    Itaru Kushima, Masahiro Nakatochi, Branko Aleksic, Takashi Okada, Hiroki Kimura, Hidekazu Kato, Mako Morikawa, Toshiya Inada, Kanako Ishizuka, Youta Torii, Yukako Nakamura, Satoshi Tanaka, Miho Imaeda, Nagahide Takahashi, Maeri Yamamoto, Kunihiro Iwamoto, Yoshihiro Nawa, Nanayo Ogawa, Shuji Iritani, Yu Hayashi, Tzuyao Lo, Gantsooj Otgonbayar, Sho Furuta, Nakao Iwata, Masashi Ikeda, Takeo Saito, Kohei Ninomiya, Tomo Okochi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kenichiro Miura, Masanari Itokawa, Makoto Arai, Mitsuhiro Miyashita, Kazuya Toriumi, Kazutaka Ohi, Toshiki Shioiri, Kiyoyuki Kitaichi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Tsukasa Sasaki, Mamoru Tochigi, Fumichika Nishimura, Hidenori Yamasue, Hitoshi Kuwabara, Tomoyasu Wakuda, Takahiro A. Kato, Shigenobu Kanba, Hideki Horikawa, Masahide Usami, Masaki Kodaira, Kyota Watanabe, Takeo Yoshikawa, Tomoko Toyota, Shigeru Yokoyama, Toshio Munesue, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Minyoung Jung, Kiyoto Kasai, Tempei Ikegame, Seiichiro Jinde, Shusuke Numata, Makoto Kinoshita, Tadafumi Kato, Chihiro Kakiuchi, Kazuhiro Yamakawa, Toshimitsu Suzuki, Naoki Hashimoto, Shuhei Ishikawa, Bun Yamagata, Shintaro Nio, Toshiya Murai, Shuraku Son, Yasuto Kunii, Hirooki Yabe, Masumi Inagaki, Yu-ichi Goto, Yuto Okumura, Tomoya Ito, Yuko Arioka, Daisuke Mori, Norio Ozaki

    Biological Psychiatry   Vol. 92 ( 5 ) page: 362 - 374   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    BACKGROUND: We aimed to determine the similarities and differences in the roles of genic and regulatory copy number variations (CNVs) in bipolar disorder (BD), schizophrenia (SCZ), and autism spectrum disorder (ASD). METHODS: Based on high-resolution CNV data from 8708 Japanese samples, we performed to our knowledge the largest cross-disorder analysis of genic and regulatory CNVs in BD, SCZ, and ASD. RESULTS: In genic CNVs, we found an increased burden of smaller (<100 kb) exonic deletions in BD, which contrasted with the highest burden of larger (>500 kb) exonic CNVs in SCZ/ASD. Pathogenic CNVs linked to neurodevelopmental disorders were significantly associated with the risk for each disorder, but BD and SCZ/ASD differed in terms of the effect size (smaller in BD) and subtype distribution of CNVs linked to neurodevelopmental disorders. We identified 3 synaptic genes (DLG2, PCDH15, and ASTN2) as risk factors for BD. Whereas gene set analysis showed that BD-associated pathways were restricted to chromatin biology, SCZ and ASD involved more extensive and similar pathways. Nevertheless, a correlation analysis of gene set results indicated weak but significant pathway similarities between BD and SCZ or ASD (r = 0.25-0.31). In SCZ and ASD, but not BD, CNVs were significantly enriched in enhancers and promoters in brain tissue. CONCLUSIONS: BD and SCZ/ASD differ in terms of CNV burden, characteristics of CNVs linked to neurodevelopmental disorders, and regulatory CNVs. On the other hand, they have shared molecular mechanisms, including chromatin biology. The BD risk genes identified here could provide insight into the pathogenesis of BD.

    DOI: 10.1016/j.biopsych.2022.04.003

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  5. The genetic architecture of schizophrenia: review of large-scale genetic studies Reviewed

    Hidekazu Kato, Hiroki Kimura, Itaru Kushima, Nagahide Takahashi, Branko Aleksic, Norio Ozaki

    Journal of Human Genetics   Vol. 68 ( 3 ) page: 175 - 182   2022.7

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/s10038-022-01059-4

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    Other Link: https://www.nature.com/articles/s10038-022-01059-4

  6. Contribution of copy number variations to the risk of severe eating disorders Reviewed

    Itaru Kushima, Miho Imaeda, Satoshi Tanaka, Hidekazu Kato, Tomoko Oya‐Ito, Masahiro Nakatochi, Branko Aleksic, Norio Ozaki

    Psychiatry and Clinical Neurosciences   Vol. 76 ( 9 ) page: 423 - 428   2022.6

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Aim

    Eating disorders (EDs) are complex, multifactorial psychiatric conditions. Previous studies identified pathogenic copy number variations associated with NDDs (NDD‐CNVs) in ED patients. However, no statistical evidence for an association between NDD‐CNVs and EDs has been demonstrated. Therefore, we examined whether NDD‐CNVs confer risk for EDs.

    Methods

    Using array comparative genomic hybridization (aCGH), we conducted a high‐resolution CNV analysis of 71 severe female ED patients and 1045 female controls. According to the American College of Medical Genetics guidelines, we identified NDD‐CNVs or pathogenic/likely pathogenic CNVs in NDD‐linked loci. Gene set analysis was performed to examine the involvement of synaptic dysfunction in EDs. Clinical data were retrospectively examined for ED patients with NDD‐CNVs.

    Results

    Of the samples analyzed with aCGH, 70 severe ED patients (98.6%) and 1036 controls (99.1%) passed our quality control filtering. We obtained 189 and 2539 rare CNVs from patients and controls, respectively. NDD‐CNVs were identified in 10.0% (7/70) of patients and 2.3% (24/1036) of controls. Statistical analysis revealed a significant association between NDD‐CNVs and EDs (odds ratio = 4.69, P = 0.0023). NDD‐CNVs in ED patients included 45,X and deletions at KATNAL2, DIP2A, PTPRT, RBFOX1, CNTN4, MACROD2, and FAM92B. Four of these genes were related to synaptic function. In gene set analysis, we observed a nominally significant enrichment of rare exonic CNVs in synaptic signaling in ED patients (odds ratio = 2.55, P = 0.0254).

    Conclusion

    Our study provides the first preliminary evidence that NDD‐CNVs may confer risk for severe EDs. The pathophysiology may involve synaptic dysfunction.

    DOI: 10.1111/pcn.13430

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/pcn.13430

  7. Exome sequencing of Japanese schizophrenia multiplex families supports the involvement of calcium ion channels Reviewed

    Miho Toyama, Regie Lyn Pastor Santos-Cortez, Yuto Takasaki, Aleksic Branko, Hiroki Kimura, Hidekazu Kato, Yoshihiro Nawa, Itaru Kushima, Kanako Ishizuka, Teppei Shimamura, Tomoo Ogi, Norio Ozaki

    PLOS ONE   Vol. 17 ( 5 ) page: e0268321 - e0268321   2022.5

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    Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science (PLoS)  

    Background

    Most sequencing studies of schizophrenia (SCZ) have focused on de novo genetic variants due to interpretability. However, investigating shared rare variants among patients in the same multiplex family is also important. Relatively large-scale analyses of SCZ multiplex families have been done in Caucasian populations, but whether detected variants are also pathogenic in the Japanese population is unclear because of ethnic differences in rare variants.

    Materials and methods

    We performed whole-exome sequencing (WES) of 14 Japanese SCZ multiplex families. After quality control and filtering, we identified rare variants shared among affected persons within the same family. A gene ontology (GO) analysis was performed to identify gene categories possibly affected by these candidate variants.

    Results

    We found 530 variants in 486 genes as potential candidate variants from the 14 SCZ multiplex families examined. The GO analysis demonstrated significant enrichment in calcium channel activity.

    Conclusion

    This study provides supporting evidence that calcium ion channel activity is involved in SCZ. WES of multiplex families is a potential means of identifying disease-associated rare variants for SCZ.

    DOI: 10.1371/journal.pone.0268321

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  8. Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder. Reviewed

    Sho Furuta, Branko Aleksic, Yoshihiro Nawa, Hiroki Kimura, Itaru Kushima, Kanako Ishizuka, Hidekazu Kato, Miho Toyama, Yuko Arioka, Daisuke Mori, Mako Morikawa, Toshiya Inada, Norio Ozaki

    Nagoya journal of medical science   Vol. 84 ( 2 ) page: 260 - 268   2022.5

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    A number of genomic mutations that are thought to be strongly involved in the development of schizophrenia (SCZ) and autism spectrum disorder (ASD) have been identified. Abnormalities involving oligodendrocytes have been reported in SCZ, and as a related gene, oligodendrocyte lineage transcription factor 2 (OLIG2) has been reported to be strongly associated with SCZ. In this study, based on the common disease-rare variant hypothesis, target sequencing of candidate genes was performed to identify rare mutations with a high effect size and the possibility that the identified mutations may increase the risks of SCZ and ASD in the Japanese population. In this study, the exon region of OLIG2 was targeted; 370 patients with SCZ and 192 with ASD were subjected to next-generation sequencing. As a result, one rare missense mutation (A33T) was detected. We used the Sanger method to validate this missense mutation with a low frequency (<1%), and then carried out a genetic association analysis involving 3299 unrelated individuals (1447 with SCZ, 380 with ASD, and 1472 healthy controls) to clarify whether A33T was associated with SCZ or ASD. A33T was not found in either case group, and in only one control. We did not find evidence that p.A33T is involved in the onset of ASD or SCZ; however, associations with this variant need to be evaluated in larger samples to confirm our results.

    DOI: 10.18999/nagjms.84.2.260

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  9. Sequencing of selected chromatin remodelling genes reveals increased burden of rare missense variants in ASD patients from the Japanese population Reviewed

    Tzuyao Lo, Itaru Kushima, Branko Aleksic, Hidekazu Kato, Yoshihiro Nawa, Yu Hayashi, Gantsooj Otgonbayar, Hiroki Kimura, Yuko Arioka, Daisuke Mori, Norio Ozaki

    International Review of Psychiatry   Vol. 34 ( 2 ) page: 154 - 167   2022.2

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    Publishing type:Research paper (scientific journal)   Publisher:Informa UK Limited  

    DOI: 10.1080/09540261.2022.2072193

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  10. Autism Spectrum Disorder Comorbid with Obsessive Compulsive Disorder and Eating Disorder in a Woman with NBEA Deletion Reviewed

    Hidekazu Kato, Itaru Kuhisma, Akira Yoshimi, Kanako Ishizuka, Hiroki Kimura, Branko Aleksic, Nagahide Takahashi, Takashi Okada, Norio Ozaki

    Psychiatry and Clinical Neurosciences   Vol. 76 ( 1 ) page: 36 - 38   2022.1

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    DOI: 10.1111/pcn.13309

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  11. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk Reviewed

    Mariko Sekiguchi, Akira Sobue, Itaru Kushima, Chenyao Wang, Yuko Arioka, Hidekazu Kato, Akiko Kodama, Hisako Kubo, Norimichi Ito, Masahito Sawahata, Kazuhiro Hada, Ryosuke Ikeda, Mio Shinno, Chikara Mizukoshi, Keita Tsujimura, Akira Yoshimi, Kanako Ishizuka, Yuto Takasaki, Hiroki Kimura, Jingrui Xing, Yanjie Yu, Maeri Yamamoto, Takashi Okada, Emiko Shishido, Toshiya Inada, Masahiro Nakatochi, Tetsuya Takano, Keisuke Kuroda, Mutsuki Amano, Branko Aleksic, Takashi Yamomoto, Tetsushi Sakuma, Tomomi Aida, Kohichi Tanaka, Ryota Hashimoto, Makoto Arai, Masashi Ikeda, Nakao Iwata, Teppei Shimamura, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Kiyofumi Yamada, Daisuke Mori, Norio Ozaki

    Translational Psychiatry   Vol. 10 ( 1 ) page: 247   2020.12

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    © 2020, The Author(s). Schizophrenia (SCZ) is known to be a heritable disorder; however, its multifactorial nature has significantly hampered attempts to establish its pathogenesis. Therefore, in this study, we performed genome-wide copy-number variation (CNV) analysis of 2940 patients with SCZ and 2402 control subjects and identified a statistically significant association between SCZ and exonic CNVs in the ARHGAP10 gene. ARHGAP10 encodes a member of the RhoGAP superfamily of proteins that is involved in small GTPase signaling. This signaling pathway is one of the SCZ-associated pathways and may contribute to neural development and function. However, the ARHGAP10 gene is often confused with ARHGAP21, thus, the significance of ARHGAP10 in the molecular pathology of SCZ, including the expression profile of the ARHGAP10 protein, remains poorly understood. To address this issue, we focused on one patient identified to have both an exonic deletion and a missense variant (p.S490P) in ARHGAP10. The missense variant was found to be located in the RhoGAP domain and was determined to be relevant to the association between ARHGAP10 and the active form of RhoA. We evaluated ARHGAP10 protein expression in the brains of reporter mice and generated a mouse model to mimic the patient case. The model exhibited abnormal emotional behaviors, along with reduced spine density in the medial prefrontal cortex (mPFC). In addition, primary cultured neurons prepared from the mouse model brain exhibited immature neurites in vitro. Furthermore, we established induced pluripotent stem cells (iPSCs) from this patient, and differentiated them into tyrosine hydroxylase (TH)-positive neurons in order to analyze their morphological phenotypes. TH-positive neurons differentiated from the patient-derived iPSCs exhibited severe defects in both neurite length and branch number; these defects were restored by the addition of the Rho-kinase inhibitor, Y-27632. Collectively, our findings suggest that rare ARHGAP10 variants may be genetically and biologically associated with SCZ and indicate that Rho signaling represents a promising drug discovery target for SCZ treatment.

    DOI: 10.1038/s41398-020-00917-z

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  12. Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder Reviewed

    Hidekazu Kato, Itaru Kushima, Daisuke Mori, Akira Yoshimi, Branko Aleksic, Yoshihiro Nawa, Miho Toyama, Sho Furuta, Yanjie Yu, Kanako Ishizuka, Hiroki Kimura, Yuko Arioka, Keita Tsujimura, Mako Morikawa, Takashi Okada, Toshiya Inada, Masahiro Nakatochi, Keiko Shinjo, Yutaka Kondo, Kozo Kaibuchi, Yasuko Funabiki, Ryo Kimura, Toshimitsu Suzuki, Kazuhiro Yamakawa, Masashi Ikeda, Nakao Iwata, Tsutomu Takahashi, Michio Suzuki, Yuko Okahisa, Manabu Takaki, Jun Egawa, Toshiyuki Someya, Norio Ozaki

    Translational Psychiatry   Vol. 10 ( 1 ) page: 421   2020.12

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    <title>Abstract</title>Dysregulation of epigenetic processes involving histone methylation induces neurodevelopmental impairments and has been implicated in schizophrenia (SCZ) and autism spectrum disorder (ASD). Variants in the gene encoding lysine demethylase 4C (<italic>KDM4C</italic>) have been suggested to confer a risk for such disorders. However, rare genetic variants in <italic>KDM4C</italic> have not been fully evaluated, and the functional impact of the variants has not been studied using patient-derived cells. In this study, we conducted copy number variant (CNV) analysis in a Japanese sample set (2605 SCZ and 1141 ASD cases, and 2310 controls). We found evidence for significant associations between CNVs in <italic>KDM4C</italic> and SCZ (<italic>p</italic> = 0.003) and ASD (<italic>p</italic> = 0.04). We also observed a significant association between deletions in <italic>KDM4C</italic> and SCZ (corrected <italic>p</italic> = 0.04). Next, to explore the contribution of single nucleotide variants in <italic>KDM4C</italic>, we sequenced the coding exons in a second sample set (370 SCZ and 192 ASD cases) and detected 18 rare missense variants, including p.D160N within the JmjC domain of KDM4C. We, then, performed association analysis for p.D160N in a third sample set (1751 SCZ and 377 ASD cases, and 2276 controls), but did not find a statistical association with these disorders. Immunoblotting analysis using lymphoblastoid cell lines from a case with <italic>KDM4C</italic> deletion revealed reduced KDM4C protein expression and altered histone methylation patterns. In conclusion, this study strengthens the evidence for associations between <italic>KDM4C</italic> CNVs and these two disorders and for their potential functional effect on histone methylation patterns.

    DOI: 10.1038/s41398-020-01107-7

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    Other Link: http://www.nature.com/articles/s41398-020-01107-7

  13. Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility Reviewed International journal

    Yoshihiro Nawa, Hiroki Kimura, Daisuke Mori, Hidekazu Kato, Miho Toyama, Sho Furuta, Yanjie Yu, Kanako Ishizuka, Itaru Kushima, Branko Aleksic, Yuko Arioka, Mako Morikawa, Takashi Okada, Toshiya Inada, Kozo Kaibuchi, Masashi Ikeda, Nakao Iwata, Michio Suzuki, Yuko Okahisa, Jun Egawa, Toshiyuki Someya, Fumichika Nishimura, Tsukasa Sasaki, Norio Ozaki

    Human Genome Variation   Vol. 7 ( 1 ) page: 37 - 37   2020.12

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    Disabled 1 (DAB1) is an intracellular adaptor protein in the Reelin signaling pathway and plays an essential role in correct neuronal migration and layer formation in the developing brain. DAB1 has been repeatedly reported to be associated with neurodevelopmental disorders including schizophrenia (SCZ) and autism spectrum disorders (ASD) in genetic, animal, and postmortem studies. Recently, increasing attention has been given to rare single-nucleotide variants (SNVs) found by deep sequencing of candidate genes. In this study, we performed exon-targeted resequencing of DAB1 in 370 SCZ and 192 ASD patients using next-generation sequencing technology to identify rare SNVs with a minor allele frequency <1%. We detected two rare missense mutations (G382C, V129I) and then performed a genetic association study in a sample comprising 1763 SCZ, 380 ASD, and 2190 healthy control subjects. Although no statistically significant association with the detected mutations was observed for either SCZ or ASD, G382C was found only in the case group, and in silico analyses and in vitro functional assays suggested that G382C alters the function of the DAB1 protein. The rare variants of DAB1 found in the present study should be studied further to elucidate their potential functional relevance to the pathophysiology of SCZ and ASD.

    DOI: 10.1038/s41439-020-00125-7

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  14. Urine screening for patients with developmental disabilities detected a patient with creatine transporter deficiency due to a novel missense mutation in SLC6A8 Reviewed International journal

    Hidekazu Kato, Fuyu Miyake, Hiroko Shimbo, Makoto Ohya, Hidenori Sugawara, Noriko Aida, Rie Anzai, Mariko Takagi, Mitsuko Okuda, Kyoko Takano, Takahito Wada, Mizue Iai, Sumimasa Yamashita, Hitoshi Osaka

    Brain and Development   Vol. 36 ( 7 ) page: 630 - 633   2014.8

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    Creatine transporter deficiency (CTD) is an example of X-linked intellectual disability syndromes, caused by mutations in SLC6A8 on Xq28. Although this is the second most frequent genetic cause of intellectual disabilities in Europe or America after Fragile X syndrome, information on the morbidity of this disease is limited in Japan. Using the HPLC screening method we have established recently, we examined samples of urine of 105 patients (73 males and 32 females) with developmental disabilities at our medical center. And we have found a family with three ID boys with a novel missense mutation in SLC6A8. This is the second report of a Japanese family case of CTD. A systematic diagnostic system of this syndrome should be established in Japan to enable us to estimate its frequency and treatment.

    DOI: 10.1016/j.braindev.2013.08.004

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MISC 15

  1. てんかんの患者が利用できる社会福祉制度について

    後藤紋香, 加藤秀一, 稲田俊也

    現代医学   Vol. 69 ( 2 ) page: 60 - 65   2022.12

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  2. 「発達障がい」とはー診断概念の変遷に注目してー

    加藤秀一, 尾崎紀夫

    CLINICAL NEUROSCIENCE   Vol. 40 ( 3 ) page: 290 - 294   2022.3

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  3. 当事者・家族の期待に応えるゲノム研究とは

    林 優, 加藤 秀一, 尾崎 紀夫

    日本生物学的精神医学会誌   Vol. 33 ( 3 ) page: 117 - 122   2022

  4. 多施設共同研究とゲノム情報の集約により精神疾患の病態解明から根本的治療薬開発へ

    加藤秀一, 尾崎紀夫

    日本生物学的精神医学会誌   Vol. 32 ( 2 ) page: 89 - 93   2021.6

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  5. 自閉スペクトラム症ゲノム解析の現状-当事者・家族の期待に応える成果を目指して-

    加藤秀一, 有岡祐子, 尾崎紀夫

    児童青年精神医学とその近接領域   Vol. 62 ( 4 ) page: 440 - 445   2021

  6. Challenges and opportunities for early career child mental health professionals during the COVID19 pandemic Reviewed

    Sundar Gnanavel, Tanay Maiti, Pawan Sharma, Darpan Kaur, Fransiska Kaligis, Jane Pei-Chen Chang, Hidekazu Kato, Asilay Seker, Dmytro Martsenkovskyi, Massimiliano Orri, Sifat E. Syed, Evelyne Baroud, Muftau Mohammed, Julia Dray, Aarya K. Rajalakshmi, Dorottya Ori, Tze Jui Goh, Anna Sofie Hansen, Ana Munjiza, Alessia Delle Grottaglie

    Asian Journal of Psychiatry   Vol. 54   page: 102443 - 102443   2020.12

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    Publisher:Elsevier {BV}  

    DOI: 10.1016/j.ajp.2020.102443

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  7. Child and adolescent psychiatry research during the COVID-19 pandemic Reviewed

    Sundar Gnanavel, Massimiliano Orri, Muftau Mohammed, Julia Dray, Evelyne Baroud, Hidekazu Kato, Goh Tze Jui, Aarya K Rajalakshmi, Anna Sofie Hansen, Asilay Seker, Dorottya Ori, Ana Munjiza, Dmytro Martsenkovskyi

    The Lancet Psychiatry   Vol. 7 ( 9 ) page: 735 - 735   2020.9

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    DOI: 10.1016/s2215-0366(20)30314-x

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  8. 【発達障害支援の現状と今後の方向性をめぐって】ASDをかかえる成人を対象としたショートケアプログラムの実際 愛知県精神医療センターでの実践

    中岡 健太郎, 加藤 秀一, 沢出 新吾, 原口 留里, 大村 豊

    心と社会   Vol. 51 ( 1 ) page: 31 - 36   2020.3

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    Language:Japanese   Publisher:(公財)日本精神衛生会  

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  9. Child and adolescent psychiatry training curriculum: a global trainee's perspective Reviewed

    Sundar Gnanavel, Pawan Sharma, Antonin Sebela, Teresa Gomez Alemany, Jane Pei-Chen Chang, Mauro Victor de Medeiros Filho, Kwabena Kusi-Mensah, Fransiska Kaligis, Hidekazu Kato, Huu Kim Le, Kana Morimoto, Dmytro Martsenkovskyi, Darpan Kaur Mohinder Singh, Aditya Pawar, Asilay Seker, Napat Sittanomai, Sifat-e Syed, Utkarsh Karki, Arpit Parmar, Marcus Tan

    BJPsych International   Vol. 17 ( 3 ) page: 1 - 3   2020.2

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    Publisher:Royal College of Psychiatrists  

    DOI: 10.1192/bji.2020.8

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  10. 自閉スペクトラム症―診断上の留意点と,発症メカニズムの最近の知見について― Reviewed

    Hidekazu Kato

    臨床神経学   Vol. 59 ( 1 ) page: 13 - 20   2019.1

  11. 【プライマリ・ケア医だからできる精神症状への関わりかた よりよい考え方、話の聴き方、向き合い方】発達障害の特性に配慮した身体診察のコツ 自閉スペクトラム症を中心に

    加藤 秀一, 増田 史, 長 徹二

    Gノート   Vol. 4 ( 8 ) page: 1402 - 1410   2017.12

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    Language:Japanese   Publisher:(株)羊土社  

    <Point>●発達障害の特性を有する方の身体診療時には、本人、家族、そして医療者ともに困難を感じることが少なくない●本人の能力や特性に合わせた配慮をすることで、その困難は解消されることも多い●感覚過敏への対応、見通しをもちやすくするための対応、そして視覚認知の強さなどの強みを活かした対応などを意識するとよい●能力や特性の個人差は大きく、診察のしかたについて家族ともよく相談をするとよい(著者抄録)

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  12. FOOD REPERTOIRE AND NUTRITIONAL DEFICIENCY IN JAPANESE CHILDREN WITH AUTISM SPECTRUM DISORDERS Reviewed

      Vol. 58 ( 3 ) page: 389 - 397   2017.6

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  13. 児童精神科医からみた読書療法の可能性

    加藤 秀一

    全国患者図書サービス連絡会会報   Vol. 21 ( 4 ) page: 43 - 46   2015.7

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    Language:Japanese   Publisher:全国患者図書サービス連絡会  

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  14. 小児における末梢静脈ラインの間欠注入ロックに関する文献的考察 Reviewed

    加藤 秀一, 松井 潔

    こども医療センター医学誌   Vol. 41 ( 3 ) page: 107 - 109   2012.7

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    Language:Japanese   Publisher:神奈川県立こども医療センター  

    患児の安全と持続点滴の拘束から解放するため末梢静脈路の間欠注入ロックは有用である。その方法にはヘパリン生食によるロックと生理食塩水によるロックがある。当院では主にヘパリン生食が用いられているが、両者の利点と欠点について検討した。末梢静脈路の維持において、開通率や静脈炎の頻度は両者に差はないが、ヘパリンロックに比べ生食ロックは安全かつ経済的であると考えられた。ヘパリンロックに比べて生食ロックではルート内に血栓が作られやすいので右左シャントを持つ先天性心疾患の児ではヘパリンロックを用いた方が良いと考えられた。いずれの方法をとる際も陽圧をかけながらロックすることが重要である。(著者抄録)

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  15. 新型インフルエンザ(A/H1N1)により急性呼吸障害を呈した18例の臨床的検討 Reviewed

    加藤 秀一, 松井 潔, 林 拓也, 西村 洋子, 山本 敦子, 宮城 崇史, 甲賀 健史, 山本 亜矢子, 梅原 直

    こども医療センター医学誌   Vol. 40 ( 3 ) page: 191 - 195   2011.7

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    Language:Japanese   Publisher:神奈川県立こども医療センター  

    2009年に大流行したパンデミックインフルエンザA(H1N1)の多くは軽症例であったが、急速に呼吸不全をきたす重症例がみられた。当センターでは3次医療機関として主に重症例の診療にあたった。今回、当科で経験した重症例の臨床像を明らかにするため、挿管群と非挿管群に分けて比較し、呼吸管理を要する児の危険因子を検討した。両群とも男児が多く、喘息の既往を持つ例が多かった。症状発現後、急速に呼吸不全に至ったが、治療開始後は両群とも比較的速やかに症状は改善したことから早期介入が重要であると考えられた。重症化の危険因子については、酸素化障害のみ重要な臨床指標であることが明らかとなった。他の予後因子を明らかにするには、軽症例と重症例を比較検討する必要がある。(著者抄録)

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Presentations 24

  1. COVID-19パンデミック前後での児童思春期摂食障害患者の臨床像の変化

    松井健、加藤秀一、名和佳弘、今枝美穂、高橋長秀

    第64回日本児童青年精神医学会  2023.11 

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    Event date: 2023.11

    Presentation type:Oral presentation (general)  

  2. 診断に苦慮した中等度知的発達症(知的能力障害)を伴う過眠障害(特発性過眠症)男児の一例 -小児の睡眠障害の評価における睡眠検査の重要性-

    中村啓喜、加藤秀一、尾崎紀夫

    第64回日本児童青年精神医学会  2023.11 

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    Event date: 2023.11

    Presentation type:Poster presentation  

    Venue:弘前  

  3. 脳動静脈奇形の出血後に注意欠如多動性症状を呈した1例

    大野由佳、名和佳弘、加藤秀一、高橋長秀

    第45回日本生物学的精神医学会  2023.11 

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    Event date: 2023.11

    Presentation type:Poster presentation  

  4. Child and Adolescent Psychiatry Training in Japan: Current Situation and Challenges (Symposium, Child and adolescent psychiatry training system and update situation in Asian countries)

    Hidekazu Kato

    The 11th Congress of The Asian Association for Child and Adolescent Psychiatry and Allied Professions (ASCAPAP)  2023.5.26 

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    Event date: 2023.5

    Language:English   Presentation type:Symposium, workshop panel (public)  

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  5. Three cases of neurofibromatosis type 1 (NF1) with neurodevelopmental disorders -A clinical practice of child and adolescent psychiatry in in-house clinical network for NF1- International conference

    Ibuki Tomita, Hidekazu Kato, Yoshihiro Nawa, Itaru Kushima, Hiroyuki Kidokoro, Yoshihiro Nishida, Nagahide Takahashi

    The 11th Congress of The Association for Child and Adolescent Psychiatry and Allied Professions (ASCAPAP)  2023.5.26 

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    Event date: 2023.5

    Language:English   Presentation type:Poster presentation  

    Venue:Kyoto   Country:Japan  

  6. 外来移行後に治療に難渋した神経性やせ症の中学生女子の一例

    寺嶋彰子、加藤秀一、高橋長秀、尾崎紀夫

    愛知児童青年精神医学会第14回学術総会  2023.3.12 

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    Event date: 2023.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  7. 神経発達症を併存する神経線維腫症1型の3例 ―NF1院内診療ネットワークにおける児童精神科の臨床実践から―

    冨田伊吹季、名和佳弘、久島周、高橋長秀、城所博之、西田佳弘、加藤秀一

    第14回レックリングハウゼン病学会  2023.2.12 

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    Event date: 2023.2

    Presentation type:Oral presentation (general)  

  8. Genetic Counseling for ASD in Child Psychiatry: A Singleton’s Case and Cases in a Multiplex Family International conference

    Hidekazu Kato, Yoshihiro Nawa, Kanako Ishizuka, Hiroki Kimura, Itaru Kushima, Nagahide Takahashi, Norio Ozaki

    the 25th World Congress of International Association for Child and Adolescent Psychiatry and Allied Professions' (IACAPAP)  2022.12 

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    Event date: 2022.12

    Language:English   Presentation type:Poster presentation  

    Venue:DUBAI   Country:United Arab Emirates  

  9. 緊張病とその後の機能低下を認めたのち急激な症状改善を認めた自閉スペクトラム症の一女児例

    寺嶋彰子、加藤秀一、名和佳弘、小川しおり、河村雄一、高橋長秀、尾崎紀夫

    第63回児童青年精神医学会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:松本   Country:Japan  

  10. 精神科受診をきっかけにCHARGE症候群およびKallmann症候群を併存した自閉スペクトラム症と診断され支援につながった一例

    加藤秀一、守田桂子、内藤顕人、名和佳弘、石塚佳奈子、木村大樹、久島周、加藤耕治、荻朋男、尾崎紀夫

    第44回日本生物学的精神医学会  2022.11 

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    Event date: 2022.11

    Presentation type:Poster presentation  

    Venue:東京  

  11. KDM5B p.W549*が統合失調症発症に与える影響に関する検討

    加藤秀一、森大輔、羅子堯、林優、オトゴンバヤル ガンツォージ、名和佳弘、有岡祐子、木村大樹、久島周、アレクシッチ ブランコ、尾崎 紀夫

    第44回日本生物学的精神医学会  2022.11 

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    Event date: 2022.11

    Presentation type:Poster presentation  

    Venue:東京  

  12. 5歳時にてんかんを発症し、後に右扁桃体腫大が明らかになった側頭葉てんかんの1 例

    羽田野裕, 夏目淳, 前澤聡, 成田肇, 光松孝真, 鈴井良輔, 澤村文, 白木杏奈, 伊藤祐史, 山本啓之, 中田智彦, 城所博之, 種井隆文, 石崎友崇, 武藤学, 伊藤芳記, 加藤秀一, 稲田俊也, 鈴木将史, 勝野雅央

    第14回日本てんかん学会東海北陸地方会学術集会  2022.7.30 

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    Event date: 2022.7

    Presentation type:Oral presentation (general)  

  13. 右側頭葉切除後に新たに精神病性障害を発症した一例

    三輪翔紀, 加藤秀一, 前澤聡, 稲田俊也, 尾崎紀夫

    第14回日本てんかん学会東海北陸地方会学術集会  2022.7.30 

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    Event date: 2022.7

    Venue:名古屋  

  14. 頻回の自傷行為と解離・幻聴等精神症状を認めた性別違和の中学生の一例

    長崎由佳子, 加藤秀一, 高橋長秀, 尾崎紀夫

    愛知児童青年精神医学会第13回学術総会  2022.3.6 

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    Event date: 2022.3

    Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  15. 自閉スペクトラム症多発家系における遺伝カウンセリングを通じて父親の自責感が軽減した一例

    加藤 秀一, 石塚 佳奈子, 名和 佳弘, 木村 大樹, 久島 周, 高橋 長秀, 尾崎 紀夫

    第62回日本児童青年精神医学会総会  2021.11 

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    Event date: 2021.11

    Presentation type:Oral presentation (general)  

    Venue:Web  

  16. 3q29欠失を有し統合失調症と診断された4症例の報告

    名和 佳弘, 久島 周, 加藤 秀一, 木村 大樹, 阪野 正大, 橋本 亮太, 菱本 明豊, 尾崎 紀夫

    第62回日本児童青年精神医学会総会  2021.11 

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    Event date: 2021.11

    Presentation type:Oral presentation (general)  

    Venue:Web  

  17. 退行様症状を来したTurner症候群の1例

    溝渕耕輔, 久島周, 加藤 秀一, 宮嶋真理, 木村宏之, 尾崎紀夫

    日本人類遺伝学会第66回大会  2021.10 

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    Event date: 2021.10

    Presentation type:Poster presentation  

    Venue:横浜  

  18. MAP3K7新規変異を認め重篤な臨床像を呈した心脊椎手根骨顔症候群の一例

    入月 浩美, 小澤 淳一, 長崎 啓祐, 森 啓悦, 加藤 秀一, 加藤 耕治, 荻 朋男, 遠山 潤, 池内 健

    日本人類遺伝学会第66回大会  2021.10 

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    Event date: 2021.10

    Presentation type:Poster presentation  

  19. 世界の児童思春期精神科研修カリキュラムと日本の現状との比較 若手精神科医の視点から

    森本 佳奈, 大熊 彩子, 北岡 淳子, 加藤 秀一, 廣田 智也, 青山 久美, 館農 勝, 秋山 剛, 岸本 年史

    第117回日本精神神経学会学術総会  2021.9 

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    Event date: 2021.9

    Presentation type:Poster presentation  

    Venue:京都  

  20. ヒストンメチル化修飾関連遺伝子の機能ドメイン内の稀なバリアントと統合失調症および自閉スペクトラム症との関連

    加藤 秀一、羅 子堯、林 優、オトゴンバヤル ガンツォージ、古田 翔、名和 佳弘、石塚 佳奈子、木村 大樹、久島 周、アレクシッチ ブランコ、尾崎 紀夫

    第43回日本生物学的精神医学会  2021.7 

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    Event date: 2021.7

    Presentation type:Poster presentation  

  21. The cooperation between child and adolescent psychiatry and education in Japan (Research symposium, Child and adolescent psychiatry and education in Asia)

    Hidekazu Kato

    The 23rd International Association for Child and Adolescent Psychiatry and Allied Professions World Congress (IACAPAP)  2018.7 

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    Event date: 2018.7

    Presentation type:Symposium, workshop panel (public)  

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  22. Child and Adolescent Psychiatry: Overview of Training System and Update Situation in Asian Countries

    Hidekazu Kato, Li-Te Chiang, Nisarat Wadchareeudomkarn

    The 22nd International Association for Child and Adolescent Psychiatry and Allied Professions World Congress (IACAPAP)  2016.9 

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    Event date: 2016.9

    Presentation type:Oral presentation (general)  

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  23. The Training System and Challenges of Child and Adolescent Psychiatry (CAP): Perspective from Japan (WPAIC symposium, Child and Adolescent Psychiatry Training and Challenges in Asia)

    Hidekazu Kato

    WPA International Congress of Psychiatry  2015.11 

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    Event date: 2015.11

    Presentation type:Symposium, workshop panel (public)  

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  24. “Hikikomori”: a form of social withdrawal related to Japanese culture (The 14th KJYPA symposium at KNPA Conference)

    Hidekazu Kato

    The 2013 Korean Neuro-Psychiatric Association (KNPA) meeting  2013.10 

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    Event date: 2013.10

    Presentation type:Symposium, workshop panel (public)  

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KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. 精神障害の病態としてのヒストンメチル化異常ー患者におけるゲノム変異を起点としてー

    Grant number:22K15748  2022.4 - 2025.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    加藤 秀一

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  2. Dysregulation of Histone Methylation Modification in Patients with Psychiatric Disorders

    Grant number:21K20866  2021.8 - 2023.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up  Grant-in-Aid for Research Activity Start-up

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    Authorship:Principal investigator 

    Grant amount:\3120000 ( Direct Cost: \2400000 、 Indirect Cost:\720000 )

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Teaching Experience (On-campus) 2

  1. PBLチュートリアル

    2022

  2. PBLチュートリアル

    2021

 

Social Contribution 6

  1. 愛知県自閉症協会・つぼみの会 相談会

    Role(s):Advisor

    愛知県自閉症協会・つぼみの会  2024.2

  2. 愛知県青い鳥医療療育センター 地域療育研修会

    Role(s):Lecturer

    愛知県青い鳥医療療育センター  2023.9

  3. モンゴル国における子どものこころの診療を行うことの出来る医師の養成事業

    Role(s):Lecturer, Organizing member

    2023

  4. 愛知県自閉症協会・つぼみの会 高機能部相談会

    Role(s):Advisor

    愛知県自閉症協会・つぼみの会  2022.3

  5. 愛知県自閉症協会・つぼみの会 ペアレントメンター研修

    Role(s):Lecturer

    愛知県自閉症協会・つぼみの会  2022.1

  6. 発達障害医療ネットワーク連絡協議会 構成員

    Role(s):Organizing member

    あいち発達障害者支援センター  2021.5

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