Updated on 2021/11/02

写真a

 
HASHIKAWA Kazunobu
 
Organization
Graduate School of Medicine Program in Integrated Medicine Biomedical Regulation Associate professor
Graduate School
Graduate School of Medicine
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
School of Medicine Department of Medicine
Title
Associate professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(医学) ( 2006.3   神戸大学 ) 

Research Areas 1

  1. Life Science / Plastic and reconstructive surgery

Education 1

  1. 神戸大学 大学院医学系研究科博士課程医科学専攻修了

    - 2006.3

 

Papers 329

  1. Experimental study on the efficacy of a hybrid artificial nerve: The hot dog method

    Tamura Ryosuke, Hashikawa Kazunobu, Sakakibara Shunsuke, Osaki Takeo, Kitano Daiki, Maruguchi Hayato, Nomura Tadashi, Sugiyama Daisuke, Terashi Hiroto

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 44 ( 10 ) page: 711 - 717   2021.10

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    Language:Japanese   Publisher:International Journal of Artificial Organs  

    © The Author(s) 2021. Introduction: We hypothesized that hybrid artificial nerves might overcome the limitations of a nerve conduit by isolating nerve fascicles from autologous nerves. Nerve sacrifice during harvest, a drawback of conventional autologous nerve transplantation, may be reduced by the hot dog method. The hot dog method (based on the morphology of hybrid artificial nerves) adds nerve conduits to autologous nerve fascicles. Methods: Forty-eight rats with a 10-mm sciatic nerve defect were divided into six groups (n = 8 per group) according to the neural reconstruction method: autologous nerve transplantation, the hot dog method, nerve conduit, nerve fascicle transplantation, sham control, and nerve fascicle isolation were classified as Groups I, II, III, IV, V, and VI, respectively. The sciatic nerve function was assessed in these groups, a histological evaluation was performed, and statistical analyses were conducted based on these data. Results: Group III (nerve conduit) and Group IV (nerve fascicle transplantation) showed the lowest functional and axonal regenerative effects, followed by Group II (hot dog method) and Group I (autologous nerve transplantation). Group VI (nerve fascicle isolation) tended to achieve better recovery in motor function and axonal regeneration than Group I (autologous nerve transplantation). Conclusions: The hot dog method is simple, safe, and easy to execute. This method can serve as a new neural reconstruction method that uses artificial nerves.

    DOI: 10.1177/03913988211026000

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  2. Clinical Evaluation of Unsintered Hydroxyapatite Particles/Poly L-Lactide Composite Device in Craniofacial Surgery

    Osawa Sayuri, Hashikawa Kazunobu, Naruse Hidemi, Terashi Hiroto

    JOURNAL OF CRANIOFACIAL SURGERY   Vol. 32 ( 6 ) page: 2148 - 2151   2021.9

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  3. Wire Myography for Continuous Estimation of the Optimal Concentration of Topical Lidocaine as a Vasodilator in Microsurgery

    Ogawa Haruo, Kusumoto Junya, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto, Sakakibara Shunsuke

    JOURNAL OF RECONSTRUCTIVE MICROSURGERY   Vol. 37 ( 06 ) page: 541 - 550   2021.7

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    Language:Japanese   Publisher:Journal of Reconstructive Microsurgery  

    Background Intraoperative vasospasm during reconstructive microvascular surgery is often unpredictable and may lead to devastating flap loss. Therefore, various vasodilators are used in reconstructive microsurgery to prevent and relieve vasospasm. Lidocaine is a vasodilator commonly used in microvascular surgery. Although many reports have described its in vitro and in vivo concentration-dependent vasodilatory effects, limited studies have examined the pharmacological effects of lidocaine on blood vessels in terms of persistence and titer. Methods In this study, the vasodilatory effect of lidocaine was examined by using the wire myograph system. Abdominal aortas were harvested from female rats, sliced into rings of 1-mm thickness, and mounted in the wire myograph system. Next, 10, 5, 2, and 1% lidocaine solutions were applied to the artery, and the change in vasodilation force, persistence of the force, and time required to reach equilibrium were measured. Results The vasodilatory effect was confirmed in all groups following lidocaine treatment. Although strong vasodilation was observed in the 10% lidocaine group, it was accompanied by irreversible degeneration of the artery. Vasodilation in the 1% lidocaine group was weaker than that in the other groups 500 seconds after lidocaine addition (p < 0.05). Between the 5 and 2% lidocaine groups, 5% lidocaine showed a stronger vasodilatory effect 400 to 600 seconds after lidocaine addition (p < 0.01); however, there was no significant difference in these groups after 700 seconds. Additionally, there was no difference in the time required for the relaxation force to reach equilibrium among the 5, 2, and 1% lidocaine groups. Conclusion Although our study confirmed the dose-dependent vasodilatory effect of lidocaine, 5% lidocaine showed the best vasodilatory effect and continuity with minimal irreversible changes in the arterial tissue.

    DOI: 10.1055/s-0040-1722759

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  4. Occurrence and Treatment Outcome of Late Complications After Free Fibula Flap Reconstruction for Mandibular Osteoradionecrosis

    Yamashita Junya, Akashi Masaya, Takeda Daisuke, Kusumoto Junya, Hasegawa Takumi, Hashikawa Kazunobu

    CUREUS   Vol. 13 ( 3 ) page: e13833   2021.3

  5. Perineal reconstruction with pedicled rectus abdominis myocutaneous flap after posterior pelvic exenteration -A 3D model study

    Kitano Daiki, Osaki Takeo, Sakakibara Shunsuke, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto

    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS   Vol. 80   page: 105629   2021

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    Language:Japanese   Publisher:International Journal of Surgery Case Reports  

    Introduction: Limited literature exists regarding the positional relationship between the pedicled-rectus abdominis myocutaneous (p-RAMC) flap and residual pelvic organs post posterior pelvic exenteration (PPE). Presentation of case: Four patients underwent PPE and reconstruction with a p-RAMC flap. After harvesting the p-RAMC flap with the deep inferior epigastric artery and veins as the vascular pedicle, the intra-pelvic shortest pathway of the flap was created. We dissected the subcutaneous tissues of the flap donor site toward the perineal defect along the inner wall of the pelvis. The pubic origin of the rectus abdominis muscle was preserved. A three-dimensional model was constructed using an image processing software. The vascular pedicle ran almost linearly along the inner wall of the pelvis. The muscle belly was placed on the pelvic floor through the posterior wall of the urinary bladder which filled the dead space of the resected area. All flaps survived without significant complications. Discussion: Assigning the cranial side of the flap to the perineum and caudal side to the pelvic floor could reduce postoperative intrapelvic complications. By preserving the pubic origin of the rectus abdominis muscle, a shock absorber of the pedicle of the flap was created, preventing over-traction of the flap while passing through the intrapelvic pathway. Conclusion: A p-RAMC flap via intra-pelvic shortest pathway is an ideal reconstructive method for large skin defect in perineal area after PPE.

    DOI: 10.1016/j.ijscr.2021.02.015

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  6. Dye Laser Treatment for Capillary Malformations (Port-wine Stains) of Infants

    Nomura Tadashi, Osaki Takeo, Osawa Sayuri, Takeda Reiko, Hasegawa Yasuko, Sakakibara Shunsuke, Hashikawa Kazunobu, Terashi Hiroto

    Nippon Laser Igakkaishi   Vol. 42 ( 1 ) page: 18 - 22   2021

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    Language:Japanese   Publisher:Japan Society for Laser Surgery and Medicine  

    <p>About 3 decades have passed since the pulsed-dye laser for the treatment of capillary malformation (port-wine stain) has spread. At present, the long-pulsed pulse dye laser has become the first-choice treatment in Japan. Devices with less purpura formation have been available in recent years. Early irradiation for infants tends to be recommended, but redarkening is still a serious problem. The development of the adjunctive drug or therapy which raise the effect of the dye laser is expected</p>

    DOI: 10.2530/jslsm.jslsm-42_0004

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  7. Treatment of orbital blowout fracture using a customized rigid carrier

    Osaki Takeo, Tamura Ryosuke, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto

    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY   Vol. 48 ( 11 ) page: 1052 - 1056   2020.11

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    Language:Japanese   Publisher:Journal of Cranio-Maxillofacial Surgery  

    © 2020 Purpose: This study aimed to examine the usefulness of treating orbital blowout fracture using a customized rigid carrier. Material and methods: Patients who underwent surgery for orbital blowout fractures in our department from April 2016 to March 2019 were recruited in the study. We molded a rigid thermoplastic material into the same shape as the reconstruction material according to the 3D model and transplanted it into the orbital space along with the reconstruction material. We assessed Hertel exophthalmometry, awareness of diplopia, and the Hess area ratio (HAR%). Results: We performed this procedure in 15 patients with blowout fractures. Reconstruction materials used were iliac bone, absorbable plates, and titanium mesh in 12, 2, and 1 patient, respectively. None of the patients showed a difference of more than 2 mm on Hertel exophthalmometry. Only one patient had diplopia after surgery. The average preoperative and postoperative HAR% were 83.1 and 90.6, respectively. HAR% was more than 85% in 6 of 7 postoperative cases. Conclusions: This method can be applied for surgery using various reconstructive materials and can be a useful method, especially in patients with a wide range of orbital bone defects.

    DOI: 10.1016/j.jcms.2020.09.002

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  8. Analysis of Orbital Morphology and its Relationship With Eyelid Morphology

    Osaki Takeo, Murakami Hidetaka, Tamura Ryosuke, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto

    JOURNAL OF CRANIOFACIAL SURGERY   Vol. 31 ( 7 ) page: 1875 - 1878   2020.10

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    Language:Japanese   Publisher:The Journal of craniofacial surgery  

    Correct anatomical reconstruction of the orbital wall for function and cosmesis is important; however, this is difficult because of the structure's complexity. The authors aimed to analyze and classify orbital morphology from computed tomography (CT) images and examine the relationship between orbital morphology and eyelid morphology in the Japanese population. CT images of 60 men (right side, 29; left side, 31) and 44 women (each side, 22) were included. The lengths of the orbital medial wall and floor in the coronal plane at the anterior, middle, and posterior planes of the orbit; angle between them; simotic index; and the thickness of upper eyelid were measured. Additionally, the presence or absence of double eyelids was evaluated. Non-paired Student's t test and Pearson correlation coefficient test were used for analysis. Orbital morphology was symmetrical on both sides, and men had a larger orbit than women. Orbital morphology was classified into 2 groups according to the posterior angle, and there was a difference between the groups in the simotic index. The difference between groups may represent a genetic difference between the Jomon and Yayoi people and not only provide a new classification for the orbit of the population but also be useful in orbital reconstruction.

    DOI: 10.1097/SCS.0000000000006634

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  9. En Bloc Subtotal Temporal Bone Resection in a Case of Advanced Ear Cancer: 2-Dimensional Operative Video

    Kimura Hidehito, Taniguchi Masaaki, Shinomiya Hirotaka, Teshima Masanori, Fujita Yuichi, Hashikawa Kazunobu, Nibu Ken-ichi, Kohmura Eiji

    OPERATIVE NEUROSURGERY   Vol. 19 ( 4 ) page: E402 - E403   2020.10

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    Language:Japanese   Publisher:Operative Neurosurgery  

    DOI: 10.1093/ons/opaa124

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  10. Use of dermal fat grafts for treating anetoderma with lipoatrophy following involution of hemangiomas

    Nomura Tadashi, Nakasone Mika, Okamoto Takako, Ejiri Hirotaka, Osawa Sayuri, Hashikawa Kazunobu, Terashi Hiroto

    PEDIATRIC DERMATOLOGY   Vol. 37 ( 4 ) page: 776 - 779   2020.7

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    Language:Japanese   Publisher:Pediatric Dermatology  

    © 2020 Wiley Periodicals LLC. Infantile hemangioma (IH) is a benign vascular tumor that gradually involutes over several years. Rapidly involuting congenital hemangioma (RICH) is the relatively rare congenital vascular tumor that is fully grown at birth and does not undergo postnatal growth and involutes during the first year. However, after involution of both IH and RICH, some have severe sequelae, such as redundant skin or conspicuous scarring, requiring additional treatment. We present the case of a 6-year-old girl with a concave deformity due to subcutaneous atrophy, skin darkening, and altered skin texture of her left zygomatic region following involution of a hemangioma. We successfully treated this patient by transferring a dermal fat graft. This technique can be beneficial for atrophic sequelae after regression of a hemangioma and is easy to perform and cosmetically effective.

    DOI: 10.1111/pde.14207

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  11. OPN4 belongs to the photosensitive system of the human skin

    Kusumoto Junya, Takeo Makoto, Hashikawa Kazunobu, Komori Takahide, Tsuji Takashi, Terashi Hiroto, Sakakibara Shunsuke

    GENES TO CELLS   Vol. 25 ( 3 ) page: 215 - 225   2020.3

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    Language:Japanese   Publisher:Genes to Cells  

    © 2020 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd The human skin has previously been described to be affected by light; however, the underlying mechanism remains unknown. OPN4 (melanopsin) expression was first identified in the skin of amphibians; however, whether it is also expressed and functioned in the human skin has not yet been identified. Here, we show that OPN4 was expressed in the human skin tissue and cultures of isolated keratinocytes, melanocytes and fibroblasts. Additionally, Ca2+ influx in vitro and ex vivo and phosphorylation of extracellular signal-regulated kinases 1/2 in human fibroblasts were observed by stimulation of blue light irradiation. Notably, our findings showed that this Ca2+ influx and phosphorylation of extracellular signal-regulated kinases 1/2 are promoted in an intensity-dependent manner, indicating that the light signal is converted to an intracellular signal via OPN4 in the human skin. Overall, in this study we showed that the human skin functions as a photoreceptor by demonstrating that in human skin, the photoreceptive protein was expressed, and photoreception was conducted via photoreceptive protein.

    DOI: 10.1111/gtc.12751

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  12. Factors Preventing Prolonged Closed-Suction Drain Placement after Immediate Breast Reconstruction with Tissue Expanders.

    Tokiyoshi T, Tsunashima C, Nomura T, Hashikawa K, Terashi H, Kawamura S

    The Kobe journal of medical sciences   Vol. 65 ( 4 ) page: E132 - E137   2020.2

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  13. Results of free flap reconstruction for patients aged 80 years or older with head and neck cancer. Reviewed

    Otsuki N, Furukawa T, Avinçsal MO, Teshima M, Shinomiya H, Oshikiri T, Nakamura T, Nomura T, Hashikawa K, Nibu KI

    Auris, nasus, larynx   Vol. 47 ( 1 ) page: 123 - 127   2020.2

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  14. Cardiac metastasis in a living patient with oral cancer. Reviewed International journal

    Hisami Fujio, Naoki Otsuki, Yuto Horichi, Shungaku Yanagisawa, Mari Nishio, Masanori Teshima, Hirotaka Shinomiya, Kazunobu Hashikawa, Ken-Ichi Nibu

    Auris, nasus, larynx   Vol. 46 ( 6 ) page: 902 - 906   2019.12

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    Cardiac metastasis from head and neck cancers are very rare. Metastases to heart are mostly diagnosed at autopsy, and seldom found while patients are alive. Patients with cardiac metastasis do not present with specific symptoms in the early stages, and diagnosis is often delayed until the disease has advanced significantly. Here, we report a 66-year-old lady who was diagnosed with cardiac metastasis 10 months after surgical resection of oral cancer. She died one month following the discovery of cardiac metastasis. Cardiac metastasis should be considered when unexplained and progressive decline of general health is observed, even in the absence of abnormalities on the electrocardiogram. Early diagnosis may be made by analyzing the chronological changes in the cardiac accumulation of fluorodeoxyglucose during positron emission tomography-computed tomography scan.

    DOI: 10.1016/j.anl.2018.10.018

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  15. Dental Rehabilitation for Free Fibula Flap-Reconstructed Mandible with Scar Contracture: A Technical Note. Reviewed International journal

    Masaya Akashi, Kousuke Matsumoto, Daisuke Takeda, Junya Yamashita, Nanae Yatagai, Kazunobu Hashikawa, Takahide Komori

    Dentistry journal   Vol. 7 ( 3 )   2019.9

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    Dental rehabilitation with osseointegrated implants in reconstructed mandibles is a common procedure, but the technique still requires improvement, especially in its reliability and technical simplification. We herein report dental rehabilitation of a free fibula-reconstructed mandible with scar contracture. A vestibuloplasty technique with application of a polyglycolic acid (PGA) sheet is described. The implants were inserted into a viable fibula flap with severe scar contracture of the overlying epithelium resulting from vascular instability in skin paddle. Only the fibula periosteum was sutured after implant insertion; exposed surfaces were covered with a combination of PGA sheet and fibrin sealant. The area with PGA sheet coverage gradually healed with moderate contracture. The epithelium around the almost implants became immobilized. The implant-supported removable partial denture with custom titanium bar was acceptable. Dental rehabilitation is possible for reconstructed mandibles with severe scar contracture. Application of a PGA sheet may be useful for vestibuloplasty in patients with reconstructed mandibles.

    DOI: 10.3390/dj7030065

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  16. Effect of size difference between hemiglossectomy and reconstruction flap on oral functions: A retrospective cohort study

    Sakakibara Akiko, Kusumoto Junya, Sakakibara Shunsuke, Hasegawa Takumi, Akashi Masaya, Minannikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   Vol. 72 ( 7 ) page: 1135 - 1141   2019.7

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    Language:Japanese   Publisher:Journal of Plastic, Reconstructive and Aesthetic Surgery  

    © 2019 Background and objective: Forearm free flaps are used after hemiglossectomy. However, no investigation has been performed on whether oral functions are better preserved when sizes of the resection and reconstruction flap are exact matches, or whether the size of the resection should be changed. We aimed to retrospectively examine whether size differences between the resection and reconstruction flap affect speech and swallowing functions postoperatively, and to determine whether there are more favorable flap size ratios. Methods: This is a retrospective cohort study of patients undergoing hemiglossectomy using a forearm free flap between 2006 and 2016 at Kobe University Hospital, Japan. The effect of size difference between the resection and reconstruction flap on maintained oral function was assessed. Speech and swallowing functions were assessed, and their correlation with the ratio of the flap size to that of the resected area was determined. With these data, distribution maps of the relationship between the functional level and reconstructed dimension ratio were prepared. The more suitable reconstructed dimension ratio was examined and evaluated. The Fisher exact test, Kruskal–Wallis test, and Scheffe test were used in statistical analyses. Results: Eighty-eight patients underwent hemiglossectomy using a forearm free flap during a 10-year period. Of these cases, 66 patients were included in this study, while 22 were excluded. The ratio of the area of the reconstruction flap to that of the resection site was 0.59–2.79 (median: 1.61). Sixty patients had flaps greater than the resection area, whereas 6 had smaller flaps. Significant differences were found in speech intelligibility and swallowing function when the reconstructed dimension ratio was categorized as follows: ≤1.3, 1.3–1.8, and ≥1.8. Conclusion: Our findings suggest that postoperative deterioration of oral functions after hemiglossectomy could be reduced if reconstruction is performed using a forearm free flap with a surface area 1.3 to 1.8 times greater than that of the resection area.

    DOI: 10.1016/j.bjps.2019.03.015

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  17. Impact of retropharyngeal lymph node dissection in the surgical treatment of hypopharyngeal cancer. Reviewed International journal

    Masanori Teshima, Naoki Otsuki, Hirotaka Shinomiya, Naruhiko Morita, Tatsuya Furukawa, Koichi Morimoto, Tetsu Nakamura, Kazunobu Hashikawa, Naomi Kiyota, Ryohei Sasaki, Ken-Ichi Nibu

    Head & neck   Vol. 41 ( 6 ) page: 1738 - 1744   2019.6

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    OBJECTIVES: To evaluate the impact of retropharyngeal lymph node (RPLN) dissection in the surgical treatment of hypopharyngeal cancer. METHODS: Between 2007 and 2016, 98 previously untreated patients with pathological diagnosed hypopharyngeal squamous cell carcinoma underwent total pharyngolaryngectomy and bilateral neck dissection at Kobe University Hospital. Bilateral dissection of RPLN was simultaneously performed in all patients. Pharynx was reconstructed with free jejunal transfer in 94 patients and primarily closed in 4 patients. Postoperative chemoradiotherapy was performed in patients with high risk factors including metastasis to RPLN, multiple lymph node metastasis, extranodal invasion, and/or positive/close surgical margins. RESULTS: The median follow-up period was 25 months ranging from 1 to 105 months. RPLN adenopathy was preoperatively identified in 9 patients in FDG-positron emission tomography. All of them had pathologically diagnosed RPLN metastases, which had been controlled in all patients during the observation periods. Among the other 89 patients, 7 patients had RPLN metastasis. The 2-year overall survival rates of the patients with and without RPLN metastasis were 65.7% and 69.8% (P = .61), respectively. CONCLUSIONS: In the present study, patients with RPLN metastasis showed equally favorable oncological outcome compared with patients without RPLN metastasis. At least, ipsilateral RPLN dissection should be considered in the surgical treatment of advanced hypopharyngeal cancer and multiple neck lymph node metastasis regardless of primary subsite.

    DOI: 10.1002/hed.25608

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  18. Long-Term Effects on Volume Change in Musculocutaneous Flaps after Head and Neck Reconstruction

    Sakakibara Akiko, Kusumoto Junya, Sakakibara Shunsuke, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

    JOURNAL OF RECONSTRUCTIVE MICROSURGERY   Vol. 35 ( 4 ) page: 235 - 243   2019.5

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    Publisher:Journal of Reconstructive Microsurgery  

    DOI: 10.1055/s-0038-1672134

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  19. A Novel Plastic Surgical Technique for Treating Congenital Entropion in Asians. International journal

    Takanori Iwayama, Kazunobu Hashikawa, Takeshi Fukumoto

    Plastic and reconstructive surgery. Global open   Vol. 7 ( 4 ) page: e2122   2019.4

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    Congenital entropion is an ocular condition involving malpositioning of the eyelid, which can result in ocular pain, conjunctival epiphora, or photophobia. Noninvasive treatment is effective in some cases; however, surgical treatment is indicated when keratitis and ocular irritating symptoms occur. There is no consensus regarding the most appropriate surgical technique. Moreover, some patients complain of changes in their appearance or unwanted incision scars after surgery. In particular, individuals with certain types of Asian heritage exhibit a lower eyelid morphology that differs from that of white individuals, caused by orbital fat locational difference. Subciliary muscle bulges cause swelling in the lower eyelid called Namidabuluro and are considered to create a youthful and beautiful appearance in Asians. Accordingly, some Asian individuals tend to be sensitive about changes to the appearance of the lower eyelid. To our knowledge, no report has yet described changes to Namidabukuro during congenital entropion repair in Asians. We describe a novel surgical technique for congenital entropion repair with the creation of cosmetically natural Namidabuluro in an East Asian cohort. The study included 8 lower eyelids of 4 Japanese female patients. Scarring was not noticeable in any of the 4 cases. Eversion of the cilia and the creation of cosmetically natural Namidabuluro were accomplished in all cases. There has been no case of recurrence yet. The novel surgical technique we developed enables not only the treatment of congenital entropion but also the creation of cosmetically acceptable Namidabuluro, resulting in increased patient satisfaction.

    DOI: 10.1097/GOX.0000000000002122

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  20. Two cases of debulking surgery for lower limb diffuse plexiform neurofibroma with transcatheter arterial embolisation Reviewed

    Kitano D, Osaki Takeo, Nakasone M, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto

    Int J Surg Case Rep   Vol. 55   page: 132 - 135   2019.1

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  21. Factors preventing prolonged closed-suction drain placement after immediate breast reconstruction with tissue expanders

    Tokiyoshi T., Tsunashima C., Nomura T., Hashikawa K., Terashi H., Kawamura S.

    Kobe Journal of Medical Sciences   Vol. 65 ( 4 ) page: 132 - 137   2019

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    Language:Japanese   Publisher:Kobe Journal of Medical Sciences  

    © 2019, Kobe University School of Medicine. All rights reserved. Background: Prolonged drain placement occasionally causes complications such as infection in patients who have undergone implant-based breast reconstruction; therefore, the drainage period must be shortened to avoid complications. Purpose: To identify the factors that prevent prolonged drain placement in patients who have undergone immediate breast reconstruction with tissue expanders. Methods: This was a retrospective medical chart review of all patients who underwent immediate breast reconstruction with tissue expanders at a single center from April 2013 to March 2016. Closed-suction drains were placed in and on the implant pocket. An extra drain was positioned in the axilla in patients undergoing axillary lymph node dissection. The drains were removed at a drainage volume of ≤50 ml per 24 hours. Prolonged drain placement was defined as a period greater than the 75th percentile among all patients. Nine potential risk factors associated with prolonged drain placement were analyzed with multivariate logistic regression analysis. Results: In total, 89 tissue expanders in 89 patients were placed in this study. Prolonged drain placement, determined as ≥9 days (range, 5–14 days), was significantly associated with body mass index ≥25 kg/m2, tissue expander size ≥500 ml, and intraoperative bleeding ≥100 ml, in the multivariate analysis. Axillary lymph node dissection with extra-axillary drainage did not prolong the drainage period. Conclusions: Our findings suggested that placing an extra-axillary closed-suction drain following axillary dissection, and reducing intraoperative bleeding and surgical trauma, could prevent prolonged drain placement in immediate breast reconstruction with tissue expanders.

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  22. Mature teratoma treated as lymphatic malformation for 5 years: a case report and literature review

    Maruguchi Hayato, Nomura Tadashi, Sasaki Satoru, Hashikawa Kazunobu, Terashi Hiroto

    CASE REPORTS IN PLASTIC SURGERY AND HAND SURGERY   Vol. 6 ( 1 ) page: 63 - 68   2019

  23. Reverse vascular pedicle digital island flap with preservation of the dorsal branch of the digital nerve

    Osaki Takeo, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto

    CASE REPORTS IN PLASTIC SURGERY AND HAND SURGERY   Vol. 6 ( 1 ) page: 74 - 78   2019

  24. Two cases of debulking surgery for lower limb diffuse plexiform neurofibroma with transcatheter arterial embolisation

    Kitano Daiki, Osaki Takeo, Nakasone Mika, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto

    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS   Vol. 55   page: 132 - 135   2019

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    Publisher:International Journal of Surgery Case Reports  

    DOI: 10.1016/j.ijscr.2019.01.018

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  25. 悪性腫瘍切除後顔面再建のストラテジー-とくに比較的大きな全層欠損について-

    橋川 和信

    Skin Cancer   Vol. 34 ( 2 ) page: 78 - 82   2019

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    Publisher:日本皮膚悪性腫瘍学会  

    DOI: 10.5227/skincancer.34.78

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  26. 退縮後に摘出術を行った耳下腺乳児血管腫の治療経験 Reviewed

    丸口勇人, Nomura Tadashi, 町田怜央, 村上英毅, 高須啓之, Hashikawa Kazunobu, 寺師浩人

    日本形成外科学会会誌   Vol. 38 ( 12号 ) page: 652 - 658   2018.12

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  27. Facial artery musculomucosal flap to close an oroantral fistula

    Ohtsuki Yumi, Akashi Masaya, Hashikawa Kazunobu, Komori Takahide

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY   Vol. 30 ( 6 ) page: 492 - 495   2018.11

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    Language:Japanese   Publisher:Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology  

    © 2018 Asian AOMS(+) ASOMP(+) JSOP(+) JSOMS(+) JSOM(+) and JAMI Oroantral fistulas (OAF), which develop as a result of maxillary sinus infection caused by oroantral communication, are sometimes intractable. We present a case of closure with a facial artery musculomucosal flap (FAMM flap) for intractable OAF. A 73-year-old man presenting with an OAF and rhinorrhea was referred to our department. Twenty-eight years earlier, he had undergone bilateral radical surgery for maxillary sinusitis, and six years earlier, he underwent extraction of his right maxillary first and second molars. Six months after the dental extractions, he developed maxillary sinusitis secondary to oroantral communication. Four years after the dental extractions, he underwent endoscopic sinus surgery with closure of the OAF with a rotational pedicled palatal flap, but the OAF recurred. To treat the OAF recurrence, we used a FAMM flap. His postoperative course was good, with no OAF recurrence 6 years after surgery. FAMM flaps are useful to close intractable OAFs.

    DOI: 10.1016/j.ajoms.2018.05.001

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  28. Association between pain severity and clinicohistopathologic findings in the mandibular canal and inferior alveolar nerve of patients with advanced mandibular osteoradionecrosis Reviewed

    Yujiro Hiraoka, Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Takumi Hasegawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology   Vol. 126 ( 3 ) page: 264 - 271   2018.9

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    Objective: Pain is one of the most problematic symptoms in patients with osteoradionecrosis of the jaws. This study investigated the associations between pain severity and morphologic alterations of the mandibular canal and inferior alveolar nerve, in respective computerized tomography images and resected specimens of mandibular osteoradionecrosis. Study Design: We assessed 14 lesions in 13 patients who underwent segmental mandibulectomy for surgical debridement and simultaneous reconstruction with free fibula flap (1 patient exhibited bilateral lesions). The extent of the mandibular canal bone defect on preoperative coronal computerized tomography images and the number of inferior alveolar nerve fascicles in resected specimens were evaluated. Comparisons were made between the slight pain and extreme pain groups. In most of the patients in the extreme pain group, either mandibular canal bone defects were absent or entire circumferential defects were present
    inferior alveolar nerve fascicles were either distinguishable or completely absent in the resected specimens. Results: Although there was no statistically significant association between extreme pain and computerized tomography or histopathologic findings, the histopathologically indistinguishable inferior alveolar nerve fascicles was significantly associated with slight pain. Conclusions: The degree of degeneration of mandibular canal and inferior alveolar nerve may be associated with pain severity in patients with mandibular osteoradionecrosis.

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  29. Long-Term Effects on Volume Change in Musculocutaneous Flaps after Head and Neck Reconstruction Reviewed

    Sakakibara A, Kusumoto J, Sakakibara S, Hasegawa Takumi, Akashi Masaya, Minamikawa Tsutomu, Furudoi Shungo, Hashikawa Kazunobu, Komori Takahide

    J Reconstr Microsurg     2018.9

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  30. Complications in Salvage Surgery for Nasal and Paranasal Malignant Tumors Involving the Skull Base. Reviewed International journal

    Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Hidehito Kimura, Masaaki Taniguchi, Kazunobu Hashikawa, Eiji Kohmura, Ken-Ichi Nibu

    Journal of neurological surgery. Part B, Skull base   Vol. 79 ( 3 ) page: 224 - 228   2018.6

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    Objective  Nasal and paranasal malignant tumors invading the skull base are rare and poorly studied. We evaluated postoperative complications in patients undergoing salvage surgery for such tumors. Design  Retrospective study. Setting  Kobe University Hospital. Participants  Among 48 patients who underwent surgery for tumors involving the skull base between 1993 and 2015, 21 patients had squamous cell carcinoma, 13 had olfactory neuroblastoma, 5 had adenocarcinoma, 2 had sarcoma, 2 had adenoid cystic carcinoma, and 1 each had malignant melanoma, poorly differentiated carcinoma, undifferentiated carcinoma, myoepithelial carcinoma, and malignant peripheral nerve sheath tumor. Prior to skull base surgery, radiotherapy, chemoradiotherapy (CRT), particle radiotherapy, chemotherapy, or surgery were applied in 3, 15, 4, 5, and 3 patients, respectively. Main Outcome Measures  Main outcome measures were postoperative complications in patients who underwent skull base surgery after concomitant CRT and/or particle therapy. Results  Major postoperative complications were observed in 14 surgical procedures (29%; 2 patients with cerebral herniation, 3 with cerebrospinal fluid leakages, 3 with meningitis, 1 with hydrocephalus, 6 with epidural abscesses, 2 with local infections, and 2 with partial flap necrosis). Four patients developed ≥2 complications. One patient died of postoperative lung infarction. Three (16.7%) of 18 patients without prior treatment and 9 (50%) of 18 patients who underwent preoperative radiotherapy/CRT had severe postoperative complications. Two (50%) of four patients treated with particle radiotherapy had postoperative complications. Conclusions  CRT or particle radiotherapy were significantly associated with a high risk of severe postoperative complications after skull base surgery. Meticulous care should be taken in patients treated with radiotherapy/particle therapy prior to skull base surgery.

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  31. Computed Tomographic Evaluation of Posttreatment Soft-Tissue Changes by Using a Lymphedema Scoring System in Patients with Oral Cancer

    Akashi Masaya, Teraoka Shun, Kakei Yasumasa, Kusumoto Junya, Hasegawa Takumi, Minamikawa Tsutomu, Hashikawa Kazunobu, Komori Takahide

    LYMPHATIC RESEARCH AND BIOLOGY   Vol. 16 ( 2 ) page: 147 - 153   2018.4

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    DOI: 10.1089/lrb.2016.0063

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  32. Ultrasonography-guided Cannula Method for Hyaluronic Acid Filler Injection with Evaluation using Laser Speckle Flowgraphy Reviewed

    IWAYAMA TAKANORI, Hashikawa Kazunobu, Osaki Takeo, Yamashiro K, Horita N, Fukumoto T

    PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN   Vol. 6 ( 4 ) page: e4776 - e1776   2018.4

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  33. Ultrasonography-guided Cannula Method for Hyaluronic Acid Filler Injection with Evaluation using Laser Speckle Flowgraphy

    Iwayama Takanori, Hashikawa Kazunobu, Osaki Takeo, Yamashiro Kenjiro, Horita Nobuyuki, Fukumoto Takeshi

    PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN   Vol. 6 ( 4 ) page: e1776   2018.4

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    DOI: 10.1097/GOX.0000000000001776

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  34. A comparative study of ethanolamine oleate and polidocanol for sclerotherapy in venous malformations

    Kuramoto Y., Nomura T., Ejiri H., Kawakila I., Sakurai A., Hashikawa K., Terashi H.

    Japanese Journal of Plastic Surgery   Vol. 61 ( 4 ) page: 450 - 456   2018.4

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    © 2018 Kokuseido Publishing Co. Ltd. All rights reserved. For sclerotherapy in venous malformations, three agents, i.e., ethanol, ethanolamine oleate, and polidocanol have been used in Japan. Among these, superiority with regard to outcome and complications has rarely been discussed. Between June 2000 and July 2015, we had 187 patients with venous malformations who were treated by percutaneous sclerotherapy with surfactant sclerosants; we evaluated the efficacy and safety of the therapy retrospectively. Patients were divided into three subgroups depending on the surfactant sclerosants used for treatment: liquid ethanolamine oleate (1-EO group; n=68, 128 sessions), foamy ethanolamine oleate (f-EO group; n=56, 101 sessions), and foamy polidocanol (f-Po group; n=63, 81 sessions). High success rate with excellent and good outcomes were as follows: 71% in the 1-EO group, 65% in the f-EO group, and 78% in the f-Po group. There was no significant difference among the 3 subgroups. Hemoglobinuria occurred in 49 sessions (38%), in 26 sessions (26%), and none, in the 1-EO, f-EO, and f-Po groups, respectively. Thus, less hemoglobinuria was observed with the use of f-Po in comparison with the other two agents. Soft tissue necrosis occurred in 18 sessions (14%), 9 sessions (8%), and 2 sessions (2%) in the 1-EO, f-EO, and f-Po groups, respectively. Therefore, f-Po showed lower incidence of tissue necrosis compared with 1-EO. Since polidocanol demonstrated lower complication rates than ethanolamine oleate, while its efficacy was equivalent to that of the other agents, polidocanol is strongly recommended as a useful surfactant sclerosant for the treatment of venous malformations in Japan.

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  35. 静脈奇形に対する硬化療法におけるオレイン酸エタノールアミンとポリドカノールの比較検討 Reviewed

    倉本康世, Nomura Tadashi, 江尻浩隆, 川北育子, 櫻井敦, Hashikawa Kazunobu, 寺師浩人

    形成外科   Vol. 61 ( 4号 ) page: 450 - 456   2018.4

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  36. 腫瘍切除に伴う顔面神経麻痺の予防と治療 腫瘍切除後の顔面神経即時再建術の結果に影響を及ぼす因子は何か 同一施設・同一術式による連続症例の検討 Reviewed

    Hashikawa Kazunobu

    Facial Nerve Research   Vol. 37   page: 11 - 12   2018.2

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  37. Potential role of post-treatment follow-up FDG-PET CT to detect mandibular osteoradionecrosis: A case report Reviewed

    Akashi Masaya, WanifuchiS, KusumotoJ, KishimotoM, KakeiY, Hashikawa Kazunobu, Komori Takahide

    Mol Clin Oncol   Vol. 8 ( 1 ) page: 61 - 67   2018.1

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  38. Potential role of post-treatment follow-up FDG-PET CT to detect mandibular osteoradionecrosis: A case report

    Akashi Masaya, Wanifuchi Satoshi, Kusumoto Junya, Kishimoto Megumi, Kakei Yasumasa, Hashikawa Kazunobu, Komori Takahide

    MOLECULAR AND CLINICAL ONCOLOGY   Vol. 8 ( 1 ) page: 61 - 67   2018.1

  39. Usefulness of iliac cancellous bone grafts in orbital fracture surgery

    Hashikawa K., Nomura T., Terashi H.

    Japanese Journal of Plastic Surgery   Vol. 61 ( 1 ) page: 53 - 58   2018.1

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    © 2018 Kokuseido Publishing Co. Ltd. All rights reserved. Although various grafts using autogenous bone, autogenous cartilage, and alloplastic substitutes have been used for orbital wall reconstruction in facial fracture surgery, none have proven to be the gold-standard graft material. We have used iliac cancellous bone sheets as graft material in cases of orbital fracture. The iliac cancellous bone graft is considered the most appropriate material for orbital wall reconstruction because it is pliable enough to fit the delicate curve of the orbital wall and soft enough to be cut easily with surgical scissors. Here, we describe the details of our surgical technique for orbital floor reconstruction with iliac cancellous bone. A summary of our procedure for orbital floor fracture repair is as follows : 1. to approach the orbital floor, a subciliary incision is usually used ; 2. the fracture and defect site are exposed subperios-Teally, and the orbital content herniating into the maxillary sinus is carefully repositioned ; 3. a milli-meter-Thick bone block is harvested from the ileum; 4. the harvested block is thinned to a 1-2 mm-Thick cancellous bone sheet with a surgical burr ; 5. the sheet is adequately trimmed with surgical scissors; and 6. the sheet is placed onto the orbital floor to cover the bone defect without fixation.

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  40. A Novel Method of Noninvasive Monitoring of Free Flaps With Near-Infrared Spectroscopy Reviewed

    TakasuH, Hashikawa Kazunobu, NomuraT, SakakibaraS, Osaki Takeo, Terashi Hiroto

    Eplasty   Vol. 17   page: e37   2017.12

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  41. Axial four-dimensional computed tomographic images to analyze crosswise differences in protrusive condylar movement in patients who underwent mandibulectomy and free flap reconstruction Reviewed

    Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Michinori Maeda, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori

    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY   Vol. 45 ( 11 ) page: 1778 - 1783   2017.11

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    Objective: Few studies evaluate condylar movement following mandibular reconstruction. The main objective of this study was to show that axial four-dimensional computed tomography (4DCT) could visualize bilateral protrusive condylar movement directly. We used axial 4DCT images to assess condylar protrusion in patients who underwent mandibular reconstruction.
    Methods: We enrolled seven healthy volunteers (median age 30 years, range 27-38 years) and seven patients (median age 65 years, range 52-80 years), who underwent mandibulectomy (segmental in five, hemi in one, marginal in one) and free flap reconstruction (using the fibula in six and the radial forearm in one). Six study subjects were instructed to masticate a cookie during the 4DCT scan (the seventh made chewing motions). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT (axial view) images was then measured and compared between controls and patients using the Manne-Whitney U-test.
    Results: The crosswise difference in the distances of condylar protrusion was significantly greater in patients than in the controls.
    Conclusion: Axial 4DCT images can visualize a bilateral condylar protrusive path. Axial 4DCT images for patients who have undergone mandibulectomy and reconstruction may be useful for evaluation of functional movement of condyles. (C) 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

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  42. Literature Review of Criteria for Defining Recipient-Site Infection after Oral Oncologic Surgery with Simultaneous Reconstruction

    Akashi Masaya, Kusumoto Junya, Sakakibara Akiko, Hashikawa Kazunobu, Furudoi Shungo, Komori Takahide

    SURGICAL INFECTIONS   Vol. 18 ( 7 ) page: 755 - 764   2017.10

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    © Copyright 2017, Mary Ann Liebert, Inc. 2017. Background: The lack of uniformity of criteria for defining recipient-site infection after oral oncologic surgery with simultaneous reconstruction is problematic despite numerous studies on this issue. This study aimed to investigate the difference in the criteria for defining recipient-site infection after oral oncologic surgery with reconstruction. Methods: A Medline search was performed via PUBMED using the following combinations of key terms that were tagged in the title, abstract, or both: "surgical site infection-head neck," "surgical site infection-oral cancer," "antibiotic prophylaxis-head neck," and "surgical site infection-oral carcinoma." Search results were filtered between 2005 and 2017. Articles in which there was no mention of the criteria for definition of surgical-site infection were excluded. Results: The number of articles that met the inclusion criteria was 24. The lack of uniformity in the criteria for defining recipient-site infection in each article appeared to be attributable mainly to differences in whether an orocutaneous fistula and superficial incisional infection were regarded as recipient-site infection. Conclusion: Reconsideration of the categorization of orocutaneous fistula as infection, regardless of the etiology, and differentiation of superficial and deep incisional infections are necessary for correct assessment of recipient-site infection in oral oncologic surgery.

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  43. 色素レーザー照射後に潰瘍を生じた乳児血管腫症例の検討 Reviewed

    Nomura Tadashi, 江尻浩隆, 森脇綾, 岩山隆憲, 榊原俊介, 高須啓之, 石椛寛芳, 長谷川泰子, 橋川和信, 寺師浩人

    日本レーザー医学会誌   Vol. 38 ( 3号 ) page: 315   2017.10

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  44. Rhinoplasty via the midface degloving approach for nasal deformity due to nasal polyps: A case report of Woakes’ syndrome Reviewed

    Misato Ueda, Kazunobu Hashikawa, Takanori Iwayama, Hiroto Terashi

    Oral and Maxillofacial Surgery Cases   Vol. 3 ( 3 ) page: 64 - 69   2017.9

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    Nasal polyps are inflammatory proliferative tumors arising from the mucosa of the nasal cavity and paranasal sinuses. Although many cases concerning nasal polyps have been reported, those involving external nasal deformities are rare. We report a case of nasal polyposis filling the nasal cavity and paranasal sinuses, leading to external nasal and facial deformities. The condition above is known as Woakes’ syndrome, which is characterized by severe recurrent nasal polyps with deformity of the nasal pyramid, leading to broadening of the nose. We performed nasal osteotomy and facial bone-shaving via the midface degloving approach, which improved the patient's facial appearance.

    DOI: 10.1016/j.omsc.2017.05.001

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  45. Computed Tomographic Evaluation of Posttreatment Soft-Tissue Changes by Using a Lymphedema Scoring System in Patients with Oral Cancer Reviewed

    Akashi Masaya, TeraokaS, KakeiY, KusumotoJ, Hasegawa Takumi, MinamikawaT, Hashikawa Kazunobu, Komori Takahide

    Lymphat Res Biol     2017.7

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  46. 【頭頸部動静脈奇形の最新治療】 動静脈奇形に対する手術療法 nidusを見極めるわれわれの試み Reviewed

    Nomura Tadashi, 江尻浩隆, 櫻井敦, 川北育子, Hashikawa Kazunobu, 寺師浩人

    形成外科   Vol. 60 ( 6号 ) page: 649 - 660   2017.6

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  47. 膝窩リンパ節転移を認めた母趾悪性黒色腫の1例 Reviewed

    北川敬之, Nomura Tadashi, Hashikawa Kazunobu, Fujiwara Susumu, 田島翔子, Nishigori Chikako, Terashi Hiroto

    Skin Cancer   Vol. 31 ( 3号 ) page: 233 - 237   2017.3

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  48. Upregulated Expression of Transient Receptor Potential Cation Channel Subfamily V Receptors in Mucosae of Patients with Oral Squamous Cell Carcinoma and Patients with a History of Alcohol Consumption or Smoking Reviewed

    Akiko Sakakibara, Shunsuke Sakakibara, Junya Kusumoto, Daisuke Takeda, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori

    PLOS ONE   Vol. 12 ( 1 ) page: e0169723   2017.1

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    Objectives
    Transient receptor potential cation channel (subfamily V, members 1-4) (TRPV1-4) are expressed in skin and neurons and activated by external stimuli in normal mucosae of all oral cavity sites. The oral cavity is exposed to various stimuli, including temperature, mechanical stimuli, chemical substances, and changes in pH, and, notably, the risk factors for oncogenic transformation in oral squamous epithelium are the same as the external stimuli received by TRPV1-4 receptors. Hence, we examined the relationship between oral squamous cell carcinoma (SCC) and TRPV1-4 expression.
    Materials and Methods
    Oral SCC patients (n = 37) who underwent surgical resection were included in this study. We investigated the expression of TRPV1-4 by immunohistochemical staining and quantification of TRPV1-4 mRNA in human oral mucosa. In addition, we compared the TRPV1-4 levels in mucosa from patients with SCC to those in normal oral mucosa.
    Results
    The receptors were expressed in oral mucosa at all sites (tongue, buccal mucosa, gingiva, and oral floor) and the expression was stronger in epithelia from patients with SCC than in normal epithelia. Furthermore, alcohol consumption and tobacco use were strongly associated with the occurrence of oral cancer and were found to have a remarkable influence on TRPV1-4 receptor expression in normal oral mucosa. In particular, patients with a history of alcohol consumption demonstrated significantly higher expression levels.
    Conclusion
    Various external stimuli may influence the behavior of cancer cells. Overexpression of TRPV1-4 is likely to be a factor in enhanced sensitivity to external stimuli. These findings could contribute to the establishment of novel strategies for cancer therapy or prevention.

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  49. A Novel Method of Noninvasive Monitoring of Free Flaps With Near-Infrared Spectroscopy.

    Takasu H, Hashikawa K, Nomura T, Sakakibara S, Osaki T, Terashi H

    Eplasty   Vol. 17   page: e37   2017

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  50. Low-Grade Myxofibrosarcoma of the Rectus Abdominus Muscle Infiltrating into Abdominal Cavity: A Case Report. Reviewed International journal

    Tadashi Nomura, Shunsuke Sakakibara, Aya Moriwaki, Teruya Kawamoto, Satoshi Suzuki, Takeshi Ishimura, Kazunobu Hashikawa, Hiroto Terashi

    Eplasty   Vol. 17 ( 2 ) page: e6   2017

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    Objective: Myxofibrosarcoma (MFS) is a relatively rare tumor that is histologically characterized by myxoid stroma and spindle cell proliferation. This tumor most commonly arises as a slow growing, enlarging painless mass in the extremities of elderly patients. Methods: We report a case of a primary, low-grade MFS in the rectus abdominis muscle infiltrating the abdominal cavity of a 75-year-old man. Results: The patient underwent a wide excision of the right abdominal wall mass with a 3-cm surgical margin from the scar due to a biopsy. The tumor infiltrated the urinary bladder, peritoneum, and external iliac vessels. Twenty-six months after the initial operation, he had recurrences in his abdominal wall, urinary bladder, and right iliac vessels. Conclusions: To our knowledge, primary MFS of the muscle in the abdomen has not been documented previously. Although this case was histopathologically classified as a low-grade tumor, it infiltrated the abdominal cavity. The tumor is suspected to have penetrated the abdominal cavity below the linea arcuata, which lacks the posterior sheath of the rectus abdominis muscle; from there, it could easily spread without being blocked by any biological barriers.

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  51. Low-Grade Myxofibrosarcoma of the Rectus Abdominus Muscle Infiltrating into Abdominal Cavity: A Case Report.

    Nomura T, Sakakibara S, Moriwaki A, Kawamoto T, Suzuki S, Ishimura T, Hashikawa K, Terashi H

    Eplasty   Vol. 17   page: e6   2017

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  52. Heterogeneity of Necrotic Changes between Cortical and Cancellous Bone in Mandibular Osteoradionecrosis: A Histopathological Analysis of Resection Margin after Segmental Mandibulectomy Reviewed

    Masaya Akashi, Kazunobu Hashikawa, Satoshi Wanifuchi, Junya Kusumoto, Manabu Shigeoka, Shungo Furudoi, Hiroto Terashi, Takahide Komori

    BIOMED RESEARCH INTERNATIONAL   Vol. 2017   page: 3125842   2017

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    Background. This study aimed to analyze differences in necrotic changes between cortical and cancellous bone in resection margins after segmental mandibulectomy for advanced mandibular osteoradionecrosis. Methods. Anteroposterior bone specimens from eleven patients who underwent segmental mandibulectomy with simultaneous free fibula flap reconstruction for advanced osteoradionecrosis were analyzed histopathologically for the presence of necrotic bone based on the presence of blood vessels within Haversian canals. Results. Ten of eleven (91%) cortices near the inferior border of the mandible at the anterior margins were necrotic. All cancellous bones at the anterior margins were viable. Seven of eleven (64%) cortices near the inferior border of the mandible at the posterior margins were necrotic. Three of eleven (27%) cancellous bones at the posterior margins were necrotic. Conclusion. Necrotic changes are more prevalent in cortices than in cancellous bones in mandibular osteoradionecrosis, probably due to a decrease of periosteal blood supply caused by radiotherapy.

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  53. A case of malignant melanoma in the hallux with popliteal lymph node metastasis

    KITAGAWA Hiroshi, NOMURA Tadashi, HASHIKAWA Kazunobu, FUJIWARA Susumu, TAJIMA Shoko, NISHIGORI Chikako, TERASHI Hiroto

    Skin Cancer   Vol. 31 ( 3 ) page: 233 - 237   2017

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    <p>The present case was of a 67-year-old male patient, who detected a black spot under his left hallux nail plate approximately one year prior to his initial medical examination. Subsequently, the lesion expanded, causing destruction of the nail ; this led the patient to undergo an examination at the department of dermatology at our hospital. Clinical analysis revealed primary malignant melanoma in the left hallux. Based on positron emission tomography-computed tomography results, the patient was suspected to have popliteal and inguinal lymph node metastasis ; he was therefore referred to our department. We performed a primary tumor resection, a sentinel lymph node biopsy, and a popliteal lymph node dissection. The primary tumor had a thickness of 11 mm and had infiltrated the periosteum. The inguinal lymph node biopsy was 1/3 positive (denoting metastasis to superficial inguinal lymph node) and the popliteal lymph node dissection was 1/2 positive (denoting metastasis to deep popliteal lymph node). At a later date, we performed an inguinal lymph node dissection and lymph node metastasis was no longer observed. Invasion of the primary tumor up to the hallux periosteum suggested that the tumor may have metastasized to the deep popliteal lymph node from the periosteum via deep lymphatic vessels. In conclusion, in cases where a primary tumor extends to deep tissues, it is important to consider the possibility of flow to deep lymphatic vessels.[<i>Skin Cancer (Japan)</i> 2016 ; 31 : 233-237]</p>

    DOI: 10.5227/skincancer.31.233

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  54. Modified partial maxillary swing approach for myxofibrosarcoma in pterygopalatine fossa Reviewed

    Hikari Shimoda, Koichiro Yonezawa, Hirotaka Shinomiya, Naoki Otsuki, Kazunobu Hashikawa, Ryohei Sasaki, Eiji Komura, Ken-ichi Nibu

    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK   Vol. 38 ( 12 ) page: E2519 - E2522   2016.12

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    Background. Extirpation of tumors arising in the pterygopalatine fossa is challenging because of its anatomic complexity.
    Methods and Results. A 67-year-old man was referred to our department with a diagnosis of a tumor in his left pterygoid fossa. An incisional biopsy through the canine fossa was diagnosed as myxofibrosarcoma. The upper part of the maxilla was swung laterally to remove the tumor while the hard plate was preserved. The defect was reconstructed using rectus abdominis musculocutaneous free and ipsilateral temporal. The postoperative course was uneventful, without facial palsy or mastication disorders.
    Conclusion. Our experience with this case suggests that the modified partial maxillary swing approach with preservation of the hard palate and orbital floor in combination with infratemporal and cervical approaches is useful for lesions in the pterygoid process without causing severe complications. (C) 2016 Wiley Periodicals, Inc.

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  55. レックリングハウゼン病の下眼瞼外反に対し耳介軟骨移植とCaraji anchor suture systemで吊上げを行った1例

    高須啓之, 橋川和信, Nomura Tadashi, 寺師浩人

    日本頭蓋顎顔面外科学会誌   Vol. 32 ( 3号 ) page: 213   2016.10

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  56. 骨盤内臓全摘術後に有茎大網弁及び遊離広背筋皮弁充填術を施行した一例

    北川敬之, Nomura Tadashi, 橋川和信, 寺師浩人, 山下公大

    日本形成外科学会会誌   Vol. 36 ( 10号 ) page: 533   2016.10

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  57. Comparison between primary closure and skin grafts of the free fibula osteocutaneous flap donor site Reviewed

    Masaya Akashi, Kazunobu Hashikawa, Hiroyuki Takasu, Kazuhiro Watanabe, Junya Kusumoto, Akiko Sakakibara, Takumi Hasegawa, Tsutomu Minamikawa, Takahide Komori

    Oral and Maxillofacial Surgery   Vol. 20 ( 3 ) page: 233 - 237   2016.9

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    Purpose: This study aimed to compare the size of skin paddles, the postoperative course, and donor site complications between primary closure and skin grafts of the free fibula flap donor site. Methods: Thirty-five consecutive patients were enrolled. Medical records were retrospectively reviewed for risk factors for delayed healing, size of skin paddles, time to resumption of gait with a mobility aid and self-ambulation, early donor site morbidity, and late donor site complaints. Results: The harvested skin paddles were significantly wider in the skin graft group than in the primary closure group (P = 0.02), with no difference in length (P = 0.1). The difference in time to resuming gait with a mobility aid was also significant (P = 0.01), but not the time to self-ambulation (P = 0.9). Two early donor site morbidities (5.7 %) and 12 late donor site complaints (34.3 %) were found. No significant difference in the incidence of early donor site morbidity was observed between two groups. Occurrence of late donor site complaints was not affected by any risk factors. Conclusions: The width of the harvested skin paddle, but not the length, is one of factors involved in donor site closure. Resumption of gait with a mobility aid, but not self-ambulation, may be delayed in skin graft patients.

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  58. 治療抵抗性毛細血管奇形に対するパルス可変式色素レーザー・Nd:YAGレーザー併用療法の検討

    Nomura Tadashi, 江尻浩隆, 榊原俊介, 柳英之, 武川力, 辻依子, 田原真也, 橋川和信, 寺師浩人

    日本レーザー医学会誌   Vol. 37 ( 3号 ) page: 366   2016.9

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  59. The usefulness of a surgical suture attached with a straight needle in lymphaticovenous anastomosis

    Hashikawa K.

    Japanese Journal of Plastic Surgery   Vol. 59 ( 8 ) page: 819 - 825   2016.8

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    Recent advances in microsurgery have enabled surgical anastomosis of small vessels with calibers less than 1 mm. An anastomosis of a small vein and a lymphatic vessel, lymphaticovenous anastomosis (LVA), is an effective surgical treatment for lymphedema. However, because of the particularities of lymphatic vessels such as their small caliber and thin vessel wall, LVA is a difficult treatment to perform. This report presents the usefulness of a surgical suture attached with a straight needle in LVA. Fifty cases where LVAs were carried out with the technique were retrospectively reviewed based on technical viewpoints with medical records including operative reports and videos. The gages of threads used in the procedure were 11-0 and 12-0, and all were made of monofilament nylon. The diameters of the needles were 40um, 50um, 60um and 80um. and the lengths of needles were 3 mm, 4 mm and 5 mm. The calibers of the anastomosed lymphatic vessels were 0.2 mm to 1.0 mm. Both end-to-end and end-to-side anastomoses were performed. All the patients developed no postoperative complications related to the procedure. The review of the cases showed: (1) a back-wall first technique was useful for the anastomosis of vessels with calibers of less than 1 mm; (2) a straight needle was useful for a posterior vessel wall; (3) in particular, direction was easy to control when stabbing a vessel wall with a straight needle; (4) an anterior wall was difficult to stab with a straight needle when the wall was very thick, which was much less frequent in LVA. Some technical refinements are necessary for a reliable procedure in lymphatic microsurgery. The combination of a usual back-wall first technique and a straight needle is an effective alternative in LVA.

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  60. Four-dimensional computed tomography evaluation of jaw movement following mandibular reconstruction: A pilot study Reviewed

    Masaya Akashi, Yasuyuki Shibuya, Satoru Takahashi, Kazunobu Hashikawa, Takumi Hasegawa, Yasumasa Kakei, Noriyuki Negi, Toshinori Sekitani, Takahide Komori

    Journal of Cranio-Maxillofacial Surgery   Vol. 44 ( 5 ) page: 637 - 641   2016.5

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    Purpose The purpose of this study was to analyze jaw movement during mastication in patients who underwent mandibular reconstruction following segmental mandibulectomy, including mouth opening and mastication time, based on four-dimensional computed tomography (4D CT) images. Material and methods This study included six surgical patients, who underwent segmental mandibulectomy and simultaneous reconstruction with a free fibula osteocutaneous flap, and four controls. 4D CT was performed during mastication of a cookie to evaluate the movement of the jaw during natural function. The maximum mouth opening, mastication time, and movement of the mandibular angle during mastication were evaluated from the 4D CT images. Results 4D CT images enabled visualization of jaw movement during mastication. When compared with the controls, the maximum mouth opening during mastication and excursion of the mandibular angle, especially on the diseased side, tended to decrease in surgical patients
    however, this did not occur with mastication time. The numerical differences between the diseased and nondiseased side in surgical patients tended to be higher than the crosswise differences in controls. Conclusion 4D CT images revealed differences in jaw function between patients who underwent mandibular reconstruction and controls. 4D CT could be used to evaluate postoperative outcomes following mandibular reconstruction.

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  61. Concomitant chemoradiotherapy for advanced squamous cell carcinoma of the temporal bone. Reviewed International journal

    Hirotaka Shinomiya, Shingo Hasegawa, Daisuke Yamashita, Yasuo Ejima, Yoshida Kenji, Naoki Otsuki, Naomi Kiyota, Shunsuke Sakakibara, Tadashi Nomura, Kazunobu Hashikawa, Eiji Kohmura, Ryohei Sasaki, Ken-Ichi Nibu

    Head & neck   Vol. 38   page: E949 - E953   2016.4

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    BACKGROUND: The purpose of this study was to analyze outcomes for the treatment of locally advanced temporal bone cancer by means of concomitant chemoradiotherapy (CCRT) with a combination of cisplatin (CDDP), 5-fluorouracil (5-FU), and docetaxel (TPF). METHODS: Between 2006 and 2011, 34 patients with squamous cell carcinoma of the temporal bone were treated at Kobe University Hospital. Medical records were retrospectively reviewed to obtain information concerning patient characteristics, extent of disease, treatment, adverse events, and oncologic results. RESULTS: Ten patients were treated with CCRT using TPF regimen. The 5-year overall survival rate and disease-free survival rate were both 60%. Of special interest is that even for patients with unresectable T4 disease, the 5-year overall survival rate was 56%. CONCLUSION: The results of our study indicate that CCRT with TPF for locally advanced temporal bone cancer is an effective and promising regimen. © 2015 Wiley Periodicals, Inc. Head Neck 38: E949-E953, 2016.

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  62. A comparison of radial forearm free-flap reconstruction and non-reconstruction after partial maxillectomy. Reviewed

    Akashi M, Shibuya Y, Takahashi Y, Kusumoto J, Sakakibara A, Hasegawa T, Minamikawa T, Hashikawa K, Komori T

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.   Vol. 28 ( 2 ) page: 111 - 117   2016.3

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    DOI: 10.1016/j.ajoms.2015.08.007

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  63. 創内持続陰圧洗浄療法を用いた下腿コンパートメント症候群後皮膚潰瘍の治療

    高須啓之, 森脇綾, 橋川和信, Nomura Tadashi, 寺師浩人

    日本形成外科学会会誌   Vol. 36 ( 3号 ) page: 144   2016.3

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  64. A Study of Internal Thoracic Arteriovenous Principal Perforators by Using Multi-detector Row Computed Tomography Angiography Reviewed

    OkumuraK, Hashikawa Kazunobu, SakakibaraS, OnishiH, Terashi Hiroto

    Eplasty   Vol. 16   page: e11   2016.2

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  65. A Study of Internal Thoracic Arteriovenous Principal Perforators by Using Multi-detector Row Computed Tomography Angiography.

    Okumura K, Hashikawa K, Sakakibara S, Onishi H, Terashi H

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  66. Immediate Breast Reconstruction Performed by a Part-time Plastic Surgeon Reviewed

    Nomura Tadashi, Sakakibara Shunsuke, Saito Masaru, Kono Norio, Hashikawa Kazunobu, Terashi Hiroto

    Oncoplastic Breast Surgery   Vol. 1 ( 2 ) page: 82 - 87   2016

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    <p> In this article, we present data on immediate breast reconstruction at two hospitals without a full-time plastic surgeon, performing a retrospective chart review of patients. A reconstructive surgeon performed physical examinations on all patients and obtained their informed consent preoperatively. We explained to the patients about the limitations of reconstructive methods, for example, that free deep inferior epigastric artery flap transfer and primary silicone breast implant reconstruction were unavailable. From October 2012 to January 2016, we performed 30 immediate breast reconstructions (28 patients, 30 sites) in these hospitals ; 19 sites with autologous breast reconstruction by pedicled flap (latissimus dorsi musculocutaneous flap 18, rectus abdominis musculocutaneous flap 1) and, 11 sites (9 patients) with the tissue expander. The average length from consulting a plastic surgeon to the operation date was 26.0±14.9 days. As reconstructive methods are limited in our collaborations, this limitation was explained to the patients. Therefore, it was necessary for the reconstructive surgeon to perform a physical examination preoperatively.</p>

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  67. "Sensory switching" in elbow reconstruction Reviewed

    Shunsuke Sakakibara, Kazunobu Hashikawa, Hiroto Terashi

    Journal of Brachial Plexus and Peripheral Nerve Injury   Vol. 10 ( 1 ) page: E30 - E33   2015.12

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    In the treatment of the soft tissue defect of the elbow, flap reconstruction is necessitated in many cases because of thinness of soft tissue at this region. In addition, reacquirement of tactile sensation is desirable because of the anatomical and specific functions of the elbow. Of three cases treated for elbow defects, one was reconstructed with a pedicled island forearm flap containing the lateral cutaneous nerve of the forearm, another was reconstructed with a venoneuro-accompanying artery fasciocutaneous flap (VNAF flap) containing the basilic vein, and the third with the VNAF flap containing the cephalic vein. The three cases demonstrated a sudden change of sensory territory 4 to 6 months after surgery, which was confirmed by touching the reconstructed region with patients' eye-closed: from its original territory to the elbow in a "switching"-like action. Here we describe and discuss the concept of "sensory switching".

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  68. CT Evaluation of Morphology of Transferred Fibula for Implant Placement in Reconstructed Mandible Reviewed

    Masaya Akashi, Yasuyuki Shibuya, Satoshi Wanifuchi, Junya Kusumoto, Akiko Sakakibara, Akira Kimoto, Takumi Hasegawa, Hiroaki Suzuki, Kazunobu Hashikawa, Takahide Komori

    IMPLANT DENTISTRY   Vol. 24 ( 5 ) page: 541 - 546   2015.10

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    Background:Dental rehabilitation with osseointegrated implants in reconstructed mandibles remains one of the most challenging procedures for oral and maxillofacial surgeons. Satisfactory outcome requires appropriate assessment of graft morphology. There are few analyses of the morphology of fibulae in reconstructed mandibles, although cadaver studies on fibular shape have been performed.Materials and Methods:In this study, we used postoperative computed tomography to retrospectively evaluate the shape, height, and orientation of fibulae transferred after mandibulectomy in 19 patients.Results:The average height of transferred fibulae was 14.3 mm (range, 10.8-20.5 mm). The cross-sectional morphology of transferred fibulae could be classified into 2 types: apex and nonapex. The former type included knife-edged and triangular shapes; the latter included square and circular shapes.Conclusion:When implant insertion is planned in a reconstructed mandible, the orientation of the apex of transferred fibula should be evaluated preoperatively to allow for adjustments in implant procedure because the ridge at the apex of the fibula is narrow.

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  69. 難治性下腿潰瘍の1例

    北川敬之, Nomura Tadashi, 橋川和信, 寺師浩人, 柳沢曜

    日本形成外科学会会誌   Vol. 35 ( 10号 ) page: 626   2015.10

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  70. Sequential evaluation for bone union of transferred fibula flaps in reconstructed mandibles: panoramic X-ray versus computed tomography Reviewed

    M. Akashi, K. Hashikawa, Y. Kakei, A. Sakakibara, T. Hasegawa, T. Minamikawa, T. Komori

    INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   Vol. 44 ( 8 ) page: 942 - 947   2015.8

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    The purpose of this study was to sequentially evaluate bone union of fibular grafts in mandibular reconstruction. Patients who underwent routine follow-up computed tomography (CT) and panoramic X-ray imaging during a period of &gt;= 2 years were enrolled. On panoramic X-ray images, bone union was scored as 0 (absent callus formation) or 1 (complete callus formation). On CT images, a scale of 0 to 2 was used (0, absent callus formation; 1, complete callus formation only on the labial side; 2, complete callus formation on both the labial and lingual side). A total of 56 bone junctions were evaluated in 20 patients. Five of 56 junctions (9%) in four of 20 patients (20%) showed radiological non-union (panoramic X-ray score = 0, CT score = 0 or 1) at 2 years after surgery. All bone junctions with radiological nonunion were located at the mandibular angle. No categorical values, including diabetes mellitus and radiation therapy, were significantly associated with radiological non-union. In conclusion, assessing at least two sides (i.e. labial and lingual sides) on CT images is adequate to evaluate bone union in transferred fibula flaps. Careful fixation at the mandibular angle may improve the rate of bone union.

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  71. Necessity of Distinguishing Verrucous Carcinoma From Verrucous Skin Lesion Overlaying Residual Skin Staples in an Area of Sensory Loss: A Case Report Reviewed

    SakakibaraS, TokiyoshiT, Hashikawa Kazunobu, Terashi Hiroto

    Eplasty   Vol. 15   page: e23   2015.6

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  72. Neural circuit analysis of axons regenerated by facial-hypoglossal nerve cross-link surgery

    Sakakibara Shunsuke, Ishida Yasuhisa, Hashikawa Kazunobu, Terashi Hiroto

    REGENERATIVE THERAPY   Vol. 1   page: 86 - 90   2015.6

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    © 2015 The Japanese Society for Regenerative Medicine. Introduction: Several methods of nerve reconstruction for facial nerve palsy are known. Although the recently introduced method of "cross-linking" of the facial and hypoglossal nerves with a grafted nerve has proved efficacious, the underlying mechanism is unclear. Methods: In this study, we created an animal model with Wistar rats and analyzed the newly reconstructed neural circuit by anterograde and retrograde neural tracer methods. The saphenous nerve was harvested as a graft, and its double end-to-side neurorrhaphy with the facial and hypoglossal nerves with epineural windows was carried out under the microscope. After an appropriate interval, small amounts of fluoro-ruby or fluoro-emerald were injected into the animals and analyzed 5 days later by fluorescent microscopy (Anterograde experiment: fluoro-ruby into the hypoglossal nucleus at 5 weeks; retrograde experiment: fluoro-ruby into the distal facial nerve sheath and fluoro-emerald into the distal hypoglossal nerve sheath, both at two months.). Results: The labeled axons derived from the hypoglossal nucleus were observed passing through the grafted nerve to the facial nerve. On the other hand, retrogradely labeled neurons were observed at both the hypoglossal and facial nuclei with some double-labeled neurons, suggesting that collateral sprouting had occurred. Conclusions: We suggest that the newly constructed neural circuits we observed are conducive to the treatment of facial nerve palsy.

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  73. Does Salivary Duct Repositioning Prevent Complications After Tumor Resection or Salivary Gland Surgery? Reviewed

    Akiko Sakakibara, Tsutomu Minamikawa, Kazunobu Hashikawa, Shunsuke Sakakibara, Takumi Hasegawa, Masaya Akashi, Shungo Furudoi, Takahide Komori

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   Vol. 73 ( 5 ) page: 1003 - 1007   2015.5

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    Purpose: Tissue that is resected for the treatment of oral tumors often includes salivary gland ducts. At their institution, the authors conserve and transfer as much of the salivary duct as possible during these procedures to avoid obstructive complications. Differentiating these obstructive complications from a metastatic node can be challenging and can confound subsequent oncologic management. This study compared and examined the effectiveness of salivary duct repositioning in decreasing the incidence of obstructive complications.
    Materials and Methods: Cases of oromandibular disease treated with salivary duct resection at Kobe University Graduate School of Medicine from 2008 to 2013 were retrospectively analyzed. Thirty-two cases (25 patients) of Wharton duct resection and 31 cases (31 patients) of Stensen duct resection were included. The incidence of complications after salivary duct repositioning, duct ligation, and retention of the sublingual gland around the Wharton duct was compared.
    Results: Wharton ducts were repositioned in 30 cases and ligated in 2 cases. Complications, including oral swelling at the Wharton duct, were observed in 5 cases of repositioning and 2 cases of ligation. Stensen ducts were repositioned in 9 cases and ligated in 22 cases. The only complication reported was a single case of salivary fistula after ligation.
    Conclusions: Salivary duct repositioning is performed to prevent blockage of physiologic salivary discharge. Complications were more frequently associated with Wharton ducts than with Stensen ducts because of the unique physiologic and anatomic characteristics of the Wharton duct. Repositioning of the salivary duct is a suitable method for preventing complications associated with the Wharton duct. (c) 2015 American Association of Oral and Maxillofacial Surgeons

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  74. Evaluation of Bone Height of the Free Fibula Flap in Mandible Reconstruction

    Makiguchi Takaya, Yokoo Satoshi, Hashikawa Kazunobu, Miyazaki Hidetaka, Terashi Hiroto

    JOURNAL OF CRANIOFACIAL SURGERY   Vol. 26 ( 3 ) page: 673 - 676   2015.5

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  75. Evaluation of bone height of the free fibula flap in mandible reconstruction Reviewed

    MakiguchiT, YokooS, Hashikawa Kazunobu, MiyazakiH, Terashi Hiroto

    J Craniofac Surg   Vol. 26 ( 3 ) page: 673 - 6   2015.5

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  76. Three-Dimensional Venous Visualization with Phase-Lag Computed Tomography Angiography for Reconstructive Microsurgery Reviewed

    Shunsuke Sakakibara, Hiroyuki Onishi, Kazunobu Hashikawa, Masaya Akashi, Akiko Sakakibara, Tadashi Nomura, Hiroto Terashi

    JOURNAL OF RECONSTRUCTIVE MICROSURGERY   Vol. 31 ( 4 ) page: 305 - 312   2015.5

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    Background Most free flap reconstruction complications involve vascular compromise. Evaluation of vascular anatomy provides considerable information that can potentially minimize these complications. Previous reports have shown that contrast-enhanced computed tomography is effective for understanding three-dimensional arterial anatomy. However, most vascular complications result from venous thromboses, making imaging of venous anatomy highly desirable.
    Methods The phase-lag computed tomography angiography (pl-CTA) technique involves 64-channel (virtually, 128-channel) multidetector CT and is used to acquire arterial images using conventional CTA. Venous images are three-dimensionally reconstructed using a subtraction technique involving combined venous phase and arterial phase images, using a computer workstation.
    Results This technique was used to examine 48 patients (12 lower leg reconstructions, 34 head and neck reconstructions, and 2 upper extremity reconstructions) without complications. The pl-CTA technique can be used for three-dimensional visualization of peripheral veins measuring approximately 1 mm in diameter.
    Conclusion The pl-CTA information was especially helpful for secondary free flap reconstructions in the head and neck region after malignant tumor recurrence. In such cases, radical dissection of the neck was performed as part of the first operation, and many vessels, including veins, were resected and used in the first free-tissue transfer. The pl-CTA images also allowed visualization of varicose changes in the lower leg region and helped us avoid selecting those vessels for anastomosis. Thus, the pl-CTA-derived venous anatomy information was useful for exact evaluations during the planning of free-tissue transfers.

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  77. Postoperative abnormal response of C-reactive protein as an indicator for infectious complications after oral oncologic surgery with primary reconstruction Reviewed

    Masaya Akashi, Shungo Furudoi, Kazunobu Hashikawa, Akiko Sakakibara, Takumi Hasegawa, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori

    JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY   Vol. 44 ( April ) page: 13   2015.4

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    Background: C-reactive protein (CRP) screening has been reported to be reliable for detection of infectious complications. Postoperative abnormal response of CRP can predict wound infection in colorectal surgery. This study aimed to determine the efficacy of CRP monitoring to detect infectious complications in oral oncologic surgery.
    Methods: One hundred patients who underwent oral cancer resection with primary reconstruction were enrolled. Postoperative kinetics of CRP were classified into a normal or abnormal response.
    Results: A normal CRP response after surgery was observed in 61 patients and an abnormal response was observed in 39. There were postoperative infectious complications in 21 patients, with surgical site infections in 13 patients (early onset in six and late onset in seven). Non-wound infections were found in nine patients. Sensitivity, specificity, the positive predictive value, and the negative predictive value for abnormal CRP response as a predictor for early infectious complications were 100%, 70.1%, 35.9%, and 100%, respectively.
    Conclusion: Postoperative serial CRP screening is a useful test as an indicator of infectious complications in oral oncologic surgery. Normal CRP responses can rule out almost all early infectious complications.

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  78. Long-term Follow-up Study of Radial Forearm Free Flap Reconstruction After Hemiglossectomy Reviewed

    Masaya Akashi, Kazunobu Hashikawa, Akiko Sakakibara, Takahide Komori, Hiroto Terashi

    JOURNAL OF CRANIOFACIAL SURGERY   Vol. 26 ( 1 ) page: 48 - 51   2015.1

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    Previous studies on postoperative long-term results in patients who underwent reconstructive free flap transfer following hemiglossectomy had some issues, including the heterogeneity of the patient population and the observation period. The present study aimed to evaluate changes of reconstructed tongues in patients who underwent radial forearmfree flap (RFFF) after hemiglossectomy with long-term follow-up. We enrolled 23 patients who underwent RFFFafter hemiglossectomy with a postoperative follow-up of 5 years or more. Postoperative status (eating, speech, sensation function) was assessed by concisemedical inquiries. Morphological changes of flaps were evaluated by reviewing clinical photographs. Hemiglossectomy involving the base of the tongue was performed in 4 cases (17.4%) and was limited to the mobile tongue in 19 cases (82.6%). The mean follow-up was 85.4 months (range, 60-122 months). All patients experienced gradually improved postoperative status. The most significant improvement was found between 1 and 5 years after surgery (P = 0.007), but not between 1 and 3 years (P = 0.075) or between 3 and 5 years (P = 0.530). In almost all of the flaps, there were few morphological changes throughout the follow-up period. Postoperative status in patients who underwent reconstructive RFFF following hemiglossectomy improved sequentially.

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  79. Necessity of Distinguishing Verrucous Carcinoma From Verrucous Skin Lesion Overlaying Residual Skin Staples in an Area of Sensory Loss: A Case Report.

    Sakakibara S, Tokiyoshi T, Hashikawa K, Terashi H

    Eplasty   Vol. 15   page: e23   2015

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  80. Limitations of vascularised fibula flap for mandibular reconstruction Reviewed

    Yokoo Satoshi, Hashikawa Kazunobu, Miyazaki Hidetaka, Makiguchi Takaya, Komori Takahide

    Journal of Japanese Society of Oral Oncology   Vol. 27 ( 3 ) page: 49 - 56   2015

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    We have classified maxillofacial asymmetry from two viewpoints: the fact that all humans have an asymmetrical face, regardless of whether it appears to be normal and symmetrical, and the ability of humans to visually perceive asymmetry. In this study, based on this classification, we investigated skeletal factors influencing self-recognition after surgery in maxillofacial asymmetry patients, and attempted to apply the factors for mandibular reconstruction. We also investigated the limitation of the fibula with regard to these factors and grafted bone resorption and absolute indications. It was suggested that the positional adjustment of the chin (C: center of the mandible) is important, and that changes in the mandibular angle (A) markedly influence self-recognition of asymmetry in patients of mandibular reconstruction. Considering postoperative recognition of asymmetry, grafted fibular bone resorption, and the importance of preserving the peroneal artery for patients and prepositions towards peripheral arterial disease (PAD), the indication of mandibular reconstruction with a free fibular bone flap should be limited to the mandibular straight-line region (B: body of the mandible) not requiring osteotomy with a conserved mandibular angle.

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  81. Use of the Adherent Soft Silicone Dressing for Negative Pressure Wound Therapy

    Sakakibara Shunsuke, Osawa Sayuri, Nomura Tadashi, Hashikawa Kazunobu, Terashi Hiroto

    Japanese Journal of Surgical Wound Care   Vol. 6 ( 4 ) page: 125 - 131   2015

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    Negative pressure wound therapy (NPWT) has been introduced as a useful technique for wound treatment. However, some complications have been reported, such as infection, bleeding and pain, which make it impossible for patients to continue further treatment. Air leak is another problem, especially in hairy regions, such as the head and genital area. We have introduced a silicone gel adhesive dressing for NWPT, instead of using the film included in the original kit. The use of the silicone gel adhesive dressing greatly reduces pain, which was occurs when detaching the film. In addition, it plays a role in reducing air leak in hairy regions. Although there remains the problem of its high cost, silicone gel adhesive dressing for NPWT is quite useful.

    DOI: 10.11310/jsswc.6.125

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  82. 顔面基底細胞癌に対する外科治療−特に眼瞼および外鼻について−

    野村 正, 橋川 和信, 寺師 浩人

    Skin Cancer   Vol. 30 ( 3 ) page: 157 - 162   2015

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    DOI: 10.5227/skincancer.30.157

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  83. 開頭術後頭部皮膚潰瘍の原因に関する検討とその対策 死腔形成と脳室-腹腔シャントが及ぼす影響について Reviewed

    Nomura Tadashi, Hashikawa Kazunobu, 榊原 俊介, 高須 啓之, 寺師 浩人

    日本頭蓋顎顔面外科学会誌   Vol. 30 ( 4号 ) page: 171 - 178   2014.12

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  84. Development of a novel method for decellularizing a nerve graft using a hypertonic sodium chloride solution Reviewed

    Yasuhisa Ishida, Shuhsuke Sakakibara, Hiroto Terashi, Kazunobu Hashikawa, Tetsuji Yamaoka

    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS   Vol. 37 ( 11 ) page: 854 - 860   2014.11

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    Purpose: Acellular nerves are a reconstruction material and provide scaffolds for nerve regeneration. Numerous methods to develop acellular nerves have been described. However, these methods pose problems that can be attributed to incomplete acellular processing and destruction of the extracellular matrix (ECM); the former may lead to rejection response, while the latter may damage the scaffold. In order to overcome problems associated with the above-mentioned methods, we developed a novel method that employs a hypertonic sodium chloride solution to decellularize nerve graft material.
    Methods: Rat sciatic nerves were harvested, dipped in hypertonic sodium chloride solution (1 M), and shaken for 24 h. We then washed the nerves in phosphate-buffered saline for 7 days with shaking and evaluated the acellular nerves by hematoxylin-eosin (H-E) staining, immunostaining, and electron microscopy. We then transplanted the grafts to the sciatic nerve of another rat and evaluated the outcomes by H-E staining, immunostaining (anti-neurofilament antibody, anti-S-100 antibody), anterograde nerve tracing, and electron microscopy.
    Results: We found that our method successfully decellularized the grafts, but was mild enough to leave the ECM intact. Two months after transplantation, immunostaining and anterograde nerve tracing confirmed that Schwann cells infiltrated the grafts and induced neurofilament extension.
    Conclusions: Our methodology preserves the ECM, is simple to develop, and does not involve substances that harm biogenic tissue. Acellular nerve tissue processed in this way could become a substitute material for bridging nerve gaps. Our method could also aid in the development of other acellular tissues.

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  85. Is Immobilization of the Ankle and Metatarsophalangeal Joint Effective in Suppressing the Spread of Infection in Diabetic Foot Ulcers? Reviewed

    Shunsuke Sakakibara, Yoriko Tsuji, Kazunobu Hashikawa, Hiroto Terashi

    INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS   Vol. 13 ( 3 ) page: 226 - 229   2014.9

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    Diabetics with foot-related problems might eventually need to undergo major or minor amputation because of infection or cellulites. It has been suggested that immobilization of the ankle and the metatarsophalangeal joint suppresses the spread of infection; however, there is no evidence to support this inference. Here, we demonstrate by histological analysis how the immobilization works. The tendon from the amputated toe is harvested, and a hematoxylin-eosin stained paraffin-embedded section is prepared and analyzed. Necrosis occurred in only a single fiber of the tendon, and intact and necrotic or infected tendon fibers were found intermingled. The reciprocal movements of the tendon and the joint (extension and flexion) may be the pathogenic cause of cellulites and infection, leading to the massage effect and the spread of bacteria along the tendon itself. We suggest that immobilizing the ankle and the metatarsophalangeal joint with a removable contacting cast would suppress the spread of infection in foot ulcers.

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  86. 両側pure type眼窩ブローアウト骨折症例の検討 Reviewed

    高須 啓之, Hashikawa Kazunobu, Sakakibara Shunsuke, 寺師 浩人

    日本頭蓋顎顔面外科学会誌   Vol. 30 ( 3号 ) page: 147 - 153   2014.9

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  87. Intima/medulla reconstruction and vascular contraction-relaxation recovery for acellular small diameter vessels prepared by hyperosmotic electrolyte solution treatment Reviewed

    Shunsuke Sakakibara, Yasuhisa Ishida, Kazunobu Hashikawa, Tetsuji Yamaoka, Hiroto Terashi

    JOURNAL OF ARTIFICIAL ORGANS   Vol. 17 ( 2 ) page: 169 - 177   2014.6

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    This study aims at the evaluation of blood vessel reconstruction process of decellularized small diameter vessels prepared by a hyperosmotic electrolyte solution treatment not only histologically but also physiologically in rat transplantation model. Complete cell removal by a hyperosmotic electrolyte solution treatment was confirmed by hematoxylin/eosin staining and scanning electron microscopic observation. All acellular vessels transplanted into the rat abdominal aorta were patent up to 14 months. One week post-transplantation, the vWF-positive cells were observed on the luminal surface but the layer formation did not complete. Five weeks following transplantation, the vWF-positive endothelial cells were located on the intima consistent with intact endothelial cells. Beneath the endothelial cells, alpha-SMA-positive smooth muscle cells were distributed. The harvested vessels displayed formation of tunica intima (endothelial cells) and tunica medulla (smooth muscle cell) layers. We also examined the physiological properties of the vessels 12 months post-transplantation using a wire myograph system. The transplanted vessels contracted upon addition of norepinephrine and relaxed upon addition of sodium nitroprusside as well as the native vessels. In conclusion, the acellular vessels prepared with hyperosmotic electrolytic solution showed excellent and long-term patency, which may be related to the successful preservation of vascular ECM. In addition, the acellular vessels revealed the intima/medulla regeneration with the physiological contraction-relaxation functions in response to the each substance.

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  88. ビデオで伝えたい私の手術 ビデオで伝えたい遊離前腕皮弁の挙上方法

    Nomura Tadashi, 榊原 俊介, 高須 啓之, 橋川 和信, 寺師 浩人, 明石 昌也, 田原 真也

    日本形成外科学会会誌   Vol. 34 ( 5号 ) page: 394   2014.5

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  89. 顎下部壊死性筋膜炎に伴う切開排膿後の難治性瘻孔にV.A.C. ATS治療システムによる局所陰圧閉鎖療法を用いた1例 Reviewed

    榊原 晶子, Sakakibara Shunsuke, Minamikawa Tsutomu, 重田 崇至, Hashikawa Kazunobu, Komori Takahide

    日本口腔外科学会雑誌   Vol. 60 ( 2号 ) page: 71 - 75   2014.2

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  90. Contour-specific Foot Reconstruction

    NOMURA Tadashi, OSAKI Takeo, ISHINAGI Hiroyoshi, MORIWAKI Aya, TAKASU Hiroyuki, EJIRI Hirotaka, SAKAKIBARA Shunsuke, HASHIKAWA Kazunobu, TERASHI Hiroto

    Journal of Japanese Society of Reconstructive Microsurgery   Vol. 27 ( 3 ) page: 79 - 88   2014

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    The goal for foot reconstruction is to restore the structure and walking function. To achieve this goal, it is important to assess precisely the defects in anatomical structure, residual function, reconstructive procedure, and postoperative therapy, including rehabilitation and fitting of braces or footwear. We experienced twelve free tissue transfers and thirteen pedicle skin flaps for foot reconstruction in our hospital or branch hospitals. In all cases, tailored braces or footwear were used postoperatively under advice from a prosthetist. The free flaps we selected were: one rectus abdominis musculo-cutaneous flap, six latissimus dorsi musculo-cutaneous flaps, three groin flaps, a free scalp flap, and a scapular flap. Two of the patients who underwent free latissimus dorsi musculo-cutaneous transfer had a failed procedure due to vascular thrombus. The pedicled flaps we used were: six distally based sural flaps, five medial plantar flaps, and two lateral calcaneal flaps. Partial flap necrosis was encountered in two of six distally based sural flaps. Ulceration developed in one flap due to bulkiness. As restoring foot contour is ideal for foot reconstruction, we conclude that using thin flaps or thinning of flaps avoids bulkiness. Subsequent footwear fitting is also very important.

    DOI: 10.11270/jjsrm.27.79

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  91. Risk factors and surgical refinements of postresective mandibular reconstruction: a retrospective study Reviewed

    Sakakibara A, Hashikawa Kazunobu, Yokoo S, Sakakibara Shunsuke, Komori Takahide, Tahara S

    Plast Surg Int   Vol. 2014   page: 893746   2014

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  92. Risk factors and surgical refinements of postresective mandibular reconstruction: a retrospective study.

    Sakakibara A, Hashikawa K, Yokoo S, Sakakibara S, Komori T, Tahara S

    Plastic surgery international   Vol. 2014   page: 893746   2014

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  93. The Various Flap Monitoring after Free Flap Transfer

    SAKAKIBARA Shunsuke, NOMURA Tadashi, TAKASU Hiroyuki, HASHIKAWA Kazunobu, TERASHI Hiroto

    Journal of Japanese Society of Reconstructive Microsurgery   Vol. 27 ( 3 ) page: 72 - 78   2014

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    The development of microvascular surgery has been contributed the patients' quality of life after the expanded resection of malignant tumor or large tissue defect caused by trauma. On the other hand, vascular complication, such as thrombosis, relates to the flap necrosis and strict monitoring of flap condition is necessitated. We basically monitor the flap every 4 hours for 5 days by inspection or palpation. In addition, we have been introduced blood glucose measurement, regional oxygen saturation index ( rSO<SUB>2</SUB> ), pulse oximeter ( SpO<SUB>2</SUB> ) and indocyanine green fluorescent ( ICG ) imaging for flap auxiliary monitoring. Because each of those methods has advantage and disadvantage, understanding of characteristics of each methods may helps us the earlier detection of vascular trouble, which directly relate to the flap salvage rate.

    DOI: 10.11270/jjsrm.27.72

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  94. Summary of the chairmen

    HASEGAWA Kazuki, HASHIKAWA Kazunobu

    Journal of Japanese Society of Oral Oncology   Vol. 26 ( 3 ) page: 53 - 53   2014

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    DOI: 10.5843/jsot.26.53

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  95. Review of Critical Limb Ischemia Patients Requiring Major Amputations Because of Invasive Infection after Revascularization:: Study of Patient Risk Factors

    Nishio Yumi, Sakakibara Shunsuke, Terashi Hiroto, Hashikawa Kazunobu, Tahara Shinya

    Japanese Journal of Surgical Wound Care   Vol. 5 ( 4 ) page: 189 - 193   2014

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    In patients with critical limb ischemia ( CLI ) who have an intractable ulcer of the lower limbs, there is a higher level of need for an amputation due to severe infection after revascularization. Three out of the thirteen patients with CLI ended up with major amputations in the past five years. A comparative study was performed between these patients and those who were cured by only minor amputations. Patient factors in the comparative study included age, sex, medical history of diabetes and chronic kidney disease, diabetes medication, history of lower limb amputation on the other side, complement-reactive protein ( CRP ) levels before and after revascularization and in the early period after local surgery, and serum albumin ( Alb ) before local surgery. The patient risk factors of major amputation were late diabetic nephropathy, history of lower limb amputation on the other side and under-nutrition. There was a possibility of major amputations if patients had high CRP levels early after they completed local surgeries compared with those after revascularization. Perioperative CRP levels may be one of the indicators to use in order to avoid major amputations.

    DOI: 10.11310/jsswc.5.189

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  96. A case of an uncontrollable fistula after incisional drainage of submandibular necrotizing fasciitis treated by Negative Pressure Wound Therapy with a V.A.C.<sup>®</sup> ATS system

    SAKAKIBARA Akiko, SAKAKIBARA Shunsuke, MINAMIKAWA Tsutomu, SHIGETA Takashi, HASHIKAWA Kazunobu, KOMORI Takahide

    Japanese Journal of Oral and Maxillofacial Surgery   Vol. 60 ( 2 ) page: 71 - 75   2014

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    Necrotizing fasciitis is treated by incisional drainage or immediate debridement. Generally, an infected wound should not be sutured or closured, but should be allowed to secondarily heal as an open wound. Treatment of necrotizing fasciitis involving the neck or submandibular region requires careful attention to major blood vessels or nerves. We therefore could not perform debridement radically. The wound should be continuously irrigated or applied ointment, but the presence of a fistula sometimes leads to prolonged wound healing.<BR>We describe our experience with an uncontrollable fistula attributed to debridement of submandibular necrotizing fasciitis, although irrigation had been continued for 6 weeks. After performing Negative Pressure Wound Therapy, with a V.A.C.<sup>®</sup> ATS system good granulation tissue proliferated in 3 days, and the fistula disappeared. The wound completely healed in 1 week. Furthermore, the clinical course has been good, with no recurrence of a fistula after 3 months. We report a case of early healing of an uncontrollable fistula treated by a V.A.C.<sup>®</sup> ATS system.

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  97. CAT classification system and CAT concept for reconstruction of oncological mandibular defects (Review Article)

    Hashikawa Kazunobu

    Journal of Japanese Society of Oral Oncology   Vol. 26 ( 3 ) page: 57 - 62   2014

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    This article reports a new classification system and a practical theory in surgical reconstruction for segmental mandibular defects after oncological ablative surgery: the "CAT classification system" and the "CAT concept". The CAT classification system classifies a mandibular defect with three letters indicating reference points: "C" signifies loss of the condylar head of the mandible, "A" the mandibular angle and "T" the mental tubercle. For example, the defect is described as "A" when the mandibular angle is segmentally resected, as "CA" when the condylar head and the mandibular angle are resected, as "CAT" when the entire hemi-mandible is resected, as "ATT" when the angle and the bilateral mental tubercle are resected, as "body" when only the mandibular body is resected and the angle and the mental tubercle are preserved, and as "neck" when only the mandibular ramus is resected and the condylar head and the angle are preserved. The CAT concept is a theory that is necessary and sufficient to reconstruct three reference points of the CAT classification system ("C", "A" and "T") in order to reconstruct oncological segmental mandibular defects. Previous studies showed that the CAT system and CAT concept are highly practical and useful in the standardization of mandibular reconstructive surgery.

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  98. Comparison of Malignant Skin Tumor Thickness and Relative Depth of Invasion Estimates from Preoperative MR-Microscopy and Pathological Evaluation Reviewed

    Reiko Nakayama-Takeda, Shunsuke Sakakibara, Masato Kurokawa, Kazunobu Hashikawa, Hiroto Terashi

    DERMATOLOGIC SURGERY   Vol. 39 ( 12 ) page: 1767 - 1773   2013.12

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    BackgroundTumor thickness and relative depth of invasion are prognostic parameters considered when developing treatment plans for malignant skin tumors. Although conventional magnetic resonance (MR) imaging techniques cannot identify small tumors, use of microscopy coils considerably improves spatial resolution. Some studies have shown that this technique is efficacious in preoperative assessment of relative depth of invasion; however, its ability to provide accurate measurements of tumor thickness remains unconfirmed.
    ObjectiveThe purpose of this pilot study was to evaluate the usefulness of preoperative MR-microscopy in determining tumor thickness and relative depth of invasion of malignant skin tumors.
    Methods and MaterialsMagnetic resonance images of malignant skin tumors in seven female patients (six with basal cell carcinoma and one with malignant melanoma) were obtained using a 1.5 T system and a 47-mm or 23-mm microscopy coil. Tumors were then excised, fixed, dehydrated, embedded, and stained with hematoxylin and eosin. We then compared MR-microscopy and pathology values for thickness and relative depth of invasion of each tumor.
    ResultsBoth techniques produced similar measurements of tumor thickness and relative depth of invasion.
    ConclusionsMR-microscopy is very useful for accurate preoperative estimation of not only relative depth of invasion, but also thickness of malignant skin tumors.

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  99. Evaluation of venous anatomy with phase-lag CTA (pl-CTA)

    Sakakibara S., Onishi H., Nomura T., Hashikawa K., Terashi H.

    Japanese Journal of Plastic Surgery   Vol. 56 ( 12 ) page: 1271 - 1280   2013.12

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    Three-dimensional imaging with multidetector-row computed tomography (MDCT) provides useful information for the evaluation of arteries before an operation. However, the obtained information has been restricted only to arteries. We developed a phase lag-CT angiography (pl-CTA) method that allows three-dimensional visualization of the venous anatomy. The principle of pl-CTA is simple and consists of a phase lag and subtraction of images using a workstation. pl-CTA provides a greater amount of venous anatomical information compared to that obtained by the usual CTA.

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  100. Utility of fixation with a custom-made device for intractable digital ulcers in the proximal interphalangeal joints associated with systemic sclerosis; report of two cases

    Makiguchi T., Terashi H., Hashikawa K., Yokoo S., Tsuji Y., Tahara S.

    Japanese Journal of Plastic Surgery   Vol. 56 ( 12 ) page: 1313 - 1318   2013.12

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    Intractable cutaneous ulcers on the fingers are a common complication of systemic sclerosis (SSc). These are associated with pain and require daily treatment, which may decrease the quality of life of the patients. Digital ulcers (DUs) in the Proximal interphalangeal (PIP) joints can become intractable because the bone protrudes toward the dorsal side owing to joint flexion contracture, which induces poor circulation and persistently exerts pressure on the atrophic skin and subcutaneous tissues. In ulcers associated with a pocket, the shearing force of the joint movement, as in the case of decubitus ulcers, can also cause the ulcers to become intractable. Various treatment methods are available for vascular compromise, including pharmacotherapy, surgical revascularization, and local treatment in a moist environment; however, there are few reports of specific techniques to address the bony prominences and the shearing force. We performed fixation with a long-term-use, removable custom-made device on the palmar surfaces of the fingers, for (1) decompression of the dorsal subcutaneous tissues, (2) prevention of deviation due to joint stabilization, and (3) prevention of further flexion contractures. Herein, we report two cases of DU on the dorsal side of the PIP joint that was complicated with SSc, both of which had excellent outcomes following the use of this procedure.

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  101. 全身性強皮症に合併したPIP関節部指難治性潰瘍に対して装具固定が有用であった2例 Reviewed

    牧口 貴哉, 寺師 浩人, Hashikawa Kazunobu, 横尾 聡, 辻 依子, 田原 真也

    形成外科   Vol. 56 ( 12号 ) page: 1313 - 1318   2013.12

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  102. Functional Outcomes of the Facial Nerve After Postoperative Radiation Therapy for High-Risk Parotid Gland Malignancies Underwent Radical Surgery With Facial Nerve Resection and Reconstructive Surgery

    Muraoka O., Nishimura H., Miyawaki D., Yoshida K., Ejima Y., Okamoto Y., Hashikawa K., Otsuki N., Nibu K., Sasaki R.

    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS   Vol. 87 ( 2 ) page: S460 - S460   2013.10

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  103. Preoperative MR angiography for free fibula osteocutaneous flap transfer Reviewed

    Masaya Akashi, Tadashi Nomura, Shunsuke Sakakibara, Akiko Sakakibara, Kazunobu Hashikawa

    MICROSURGERY   Vol. 33 ( 6 ) page: 454 - 459   2013.9

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    Introduction: Magnetic resonance angiography (MRA) is currently considered the most useful test to evaluate the vascular anatomy of the lower leg prior to free fibula osteocutaneous flap transfer. This study aimed to confirm the validity of preoperative MRA. Methods: In 19 patients underwent free fibula osteocutaneous flap transfer for maxillary and mandibular reconstruction, the MRA and intraoperative findings and the postoperative complications were retrospectively analyzed. The location and number of distal septocutaneous perforators (dSCPs) that were preoperatively identified and harvested with flaps were documented. Results: Preoperative MRA detected dSCPs with 100 % sensitivity. MRA findings also revealed the diversity of vascular structures, such as the tibio-peroneal bifurcation location and the anatomical relationship between the peroneal vessels and the fibula. No patients suffered postoperative ischemic complications in the donor leg. The total flap survival rate was 95 %. Conclusions: Preoperative MRA effectively excluded large vessel anomalies and peripheral vascular disease, and precisely identified the septocutaneous perforators. Additionally, preoperative MRA contributed to a safer fibular osteotomy by predicting the anatomical relationship between the peroneal vessels and the fibula. (c) 2013 Wiley Periodicals, Inc.

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  104. 再発口腔中咽頭癌に対する遊離皮弁再建に関する検討

    Akashi Masaya, Hashikawa Kazunobu, 寺師 浩人

    日本マイクロサージャリー学会学術集会プログラム・抄録集40周年記念     page: 163   2013.9

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  105. One-Stage Umbilicus Reconstruction After Resection of Urachal Cyst Reviewed

    Makoto Omori, Kazunobu Hashikawa, Shunsuke Sakakibara, Hiroto Terashi, Shinya Tahara, Yoshie Shibaoka, Kensaku Kimura, Katsuhiro Sano

    ANNALS OF PLASTIC SURGERY   Vol. 71 ( 1 ) page: 93 - 95   2013.7

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    Umbilical reconstruction after total excision of the umbilicus represents a challenging problem for reconstructive surgeons. We describe herein a new method for one-stage umbilical reconstruction after resection of a urachal cyst. This case series included 6 patients, with laparoscopic urachal cyst removal in 5 and conventional transcutaneous surgery in 1. One-stage umbilical reconstruction was performed in all cases. When a conventional transcutaneous approach is indicated, umbilical reconstruction can be undertaken through the same skin incision used for total resection of the urachal cyst. Two triangular flaps were designed just below the umbilical defect. Flaps were rotated 180 degrees and sutured together to form one big triangular flap. This flap was then folded to create the new umbilicus. A deep umbilicus with good shape was constructed in all cases, and all patients were satisfied with the outcome. This method is simple, easy, and produces a natural-looking umbilicus.

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  106. Osteolipoma in the Glabella: Pathogenesis Associated With Mesenchymal Lipoma-Derived Stem Cells

    Makiguchi Takaya, Terashi Hiroto, Hashikawa Kazunobu, Yokoo Satoshi, Kusaka Junko

    JOURNAL OF CRANIOFACIAL SURGERY   Vol. 24 ( 4 ) page: 1310 - 1313   2013.7

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    DOI: 10.1097/SCS.0b013e3182953a0b

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  107. Osteolipoma in the glabella: pathogenesis associated with mesenchymal lipoma-derived stem cells Reviewed

    Makiguchi T, Terashi H, Hashikawa Kazunobu, Yokoo S, Kusaka J

    J Craniofac Surg   Vol. 24 ( 4 ) page: 1310 - 3   2013.7

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  108. 外傷後に生じたclaw toe変形に対し長趾屈筋腱移行術を施行した1例

    高須 啓之, Hashikawa Kazunobu, Akashi Masaya, 寺師 浩人

    日本形成外科学会会誌   Vol. 33 ( 6号 ) page: 469   2013.6

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  109. がん切除後下顎骨再建における再建理論「CATコンセプト」 臨床症例における実践結果 Reviewed

    Hashikawa Kazunobu, Akashi Masaya, 野村 正, 寺師 浩人

    頭頸部癌   Vol. 39 ( 2号 ) page: 166   2013.5

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  110. 再発口腔中咽頭癌に対する遊離皮弁再建における問題点 Reviewed

    Akashi Masaya, Hashikawa Kazunobu, 寺師 浩人

    頭頸部癌   Vol. 39 ( 2号 ) page: 198   2013.5

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  111. 当科における照射後再発下咽頭癌に対する救済手術の検討

    小松 弘和, Morimoto Koichi, 斎藤 幹, 大月 直樹, Hashikawa Kazunobu, 丹生 健一

    頭頸部癌   Vol. 39 ( 2号 ) page: 182   2013.5

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  112. 舌半側切除術後の遊離前腕皮弁再建症例における長期観察結果

    Akashi Masaya, Hashikawa Kazunobu, 榊原 晶子, 寺師 浩人

    頭頸部癌   Vol. 39 ( 2号 ) page: 161   2013.5

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  113. Supercharged pectoralis major musculocutaneous flap Reviewed

    Hashikawa Kazunobu, Terashi Hiroto

    J Craniofac Surg   Vol. 24 ( 2 ) page: e179 - 82   2013.3

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  114. Supercharged Pectoralis Major Musculocutaneous Flap

    Makiguchi Takaya, Yokoo Satoshi, Miyazaki Hidetaka, Takayama Yu, Ogawa Masaru, Hashikawa Kazunobu, Terashi Hiroto

    JOURNAL OF CRANIOFACIAL SURGERY   Vol. 24 ( 2 ) page: E179 - E182   2013.3

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    DOI: 10.1097/SCS.0b013e3182801898

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  115. Treatment strategy of a huge ameloblastic carcinoma Reviewed

    Takaya Makiguchi, Satoshi Yokoo, Hidetaka Miyazaki, Aiko Nobusawa, Masaru Ogawa, Kazunobu Hashikawa, Hiroto Terashi

    Journal of Craniofacial Surgery   Vol. 24 ( 1 ) page: 287 - 290   2013.1

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    Ameloblastic carcinoma is a very rare malignant odontogenic tumor. We report a case of secondary-type ameloblastic carcinoma that extended transversally over almost half of the side of the face. Malignant transformation and identification of the malignant region in the large tumor were achieved using L-3-[F]fluoro-α-methyltyrosine (FAMT)-positron emission tomography (PET)
    FAMT is transported into cancer cells by L-type amino acid transporter 1 and shows high specificity for malignant tumors. The malignant region determined by microscopic evaluation of resected samples was similar to the region showing high FAMT uptake in PET. Using preoperative FAMT-PET and magnetic resonance imaging, we were able to achieve total resection of the very large tumor, while avoiding excessive resection that could cause severe functional loss or a poor aesthetic facial appearance. We used a modified Weber-Fergusson incision along the nasolabial fold to the labiajugal fold and reconstruction with a pectoralis major muscle flap, and this gave a good aesthetic outcome. Safe surgical resection was possible because preoperative three-dimensional computed tomography angiography was used to identify the position of the main trunk of the external carotid artery, which was closely aligned with the tumor in a posterior direction in the infratemporal fossa region. Copyright © 2013 by Mutaz B. Habal, MD.

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  116. Clinical Evaluation of Cases with Maxillectomy Reconstructed by Both Free Flap and Dento-maxillary Prosthesis

    KOBAYASHI Masaki, SHIBUYA Yasuyuki, ISHIDA Yu, MINAMIKAWA Tsutomu, YOKOO Satoshi, HASHIKAWA Kazunobu, KOMORI Takahide

      Vol. 35 ( 2 ) page: 37 - 45   2012.12

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  117. 上顎切除後に遊離皮弁と顎義歯による再建を併用した症例の臨床的検討 Reviewed

    Shibuya Yasuyuki, Minamikawa Tsutomu, Yokoo Satoshi, Hashikawa Kazunobu, Komori Takahide

    顎顔面補綴   Vol. 35 ( 2号 ) page: 83 - 91   2012.12

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  118. 神経端側縫合の将来展望 端側神経縫合を利用した腫瘍切除後顔面神経即時再建 ループ型神経移植連続10症例の検討 Reviewed

    Hashikawa Kazunobu, 榊原 俊介

    Facial Nerve Research   Vol. 32   page: 26 - 28   2012.11

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  119. 顔面神経再建方法の分類と呼称について「ジャンプグラフト」「クロスリンク」 Reviewed

    Hashikawa Kazunobu

    Facial Nerve Research   Vol. 32   page: 38 - 40   2012.11

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  120. Comparison of reinnervation for preservation of denervated muscle volume with motor and sensory nerve: An experimental study Reviewed

    Makoto Omori, Shunsuke Sakakibara, Kazunobu Hashikawa, Hiroto Terashi, Shinya Tahara, Daisuke Sugiyama

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   Vol. 65 ( 7 ) page: 943 - 949   2012.7

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    Prevention of the atrophy of denervated muscles is essential for a good outcome in facial contouring and oral reconstruction. In this study, we compared the effectiveness of end-to-end and end-to-side neurorrhaphy of the motor nerve, and end-to-end neurorrhaphy of the sensory nerve, all of which are frequently used in such reconstruction for the prevention of muscle atrophy.
    Wistar rats were divided into four groups: group 1, motor nerve division of semimembranosus without repair; group 2, motor nerve division and end-to-end coaptation to the saphenous nerve; group 3, motor nerve division and end-to-side coaptation to the sciatic nerve; and group 4, motor nerve division and end-to-end repair.
    Measurement of semi-membranosus volume, histological evaluation and staining of neuromuscular junctions that were carried out 3 months postoperatively revealed that muscle volume preservation was larger in groups 3 and 4 than in the other two groups (p &lt; 0.05), but slightly superior in group 4 (p &lt; 0.05). There was no statistical difference between groups 2 and 1; histologically, muscle architecture was better preserved in group 2 than in group 1; reactivation of the neuromuscular junctions was observed in all except group 1.
    End-to-side repair of motor nerves is one of the better options for the preservation of muscle volume when end-to-end nerve repair is not indicated. Sensory protection may also provide some advantages in the preservation of muscle volume. (C) 2012 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bjps.2012.01.018

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  121. 【下肢~足切断術の新しいアプローチ】 趾切断時におけるfillet toe flapの利用 Invited Reviewed

    Sakakibara Shunsuke, Terashi Hiroto, Sakurai Sayuri, Hashikawa Kazunobu, Tahara Shinya

    創傷   Vol. 3 ( 3号 ) page: 123 - 128   2012.7

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  122. Intractable skin ulcerations associated with ion beam therapy

    Shibaoka Y., Hashikawa K., Sarayama Y., Niwa Y., Terashi H., Omori M., Murakami M., Tahara S.

    Japanese Journal of Plastic Surgery   Vol. 55 ( 5 ) page: 527 - 537   2012.5

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    Ion beam therapy has lately attracted considerable attention as an effective means for beating cancers. Ion beam experts say that it produces less harmful side effects than regular radiation because of its physical features. Sometimes, however, it induces severe skin damage as a side effect. We experienced seven cases of intractable ulcerations associated with ion beam therapy. Original diseases of our cases are composed of three hepatocellular carcinomas, three soft tissue sarcomas, one squamous cell carcinoma in the head and neck region. From these seven cases, we found two important clinical features of the ulcerations due to ion beam. First, severe skin necrosis or ulcerations occur frequently when cancers are located shallowly in the body, for instance hepatocellular carcinoma and soft tissue sarcomas in the extremities. Second, the outbreak of ulceration after ion beam therapy is much earlier than that of chronic ulcerations after regular radiation therapy. Conservative therapy is not effective to cure the ulcerations. We should achieve sufficiently deep debridement and reconstruct the defect by a flap rich in blood supply.

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  123. Risk Factors of Anastomotic Thrombosis in 200 Head and Neck Free Flaps among Asian Patients Reviewed

    MakiguchiT, Hashikawa Kazunobu, SugiyamaD, YokooS, TerashiH, NibuK, KumagaiS, TaharaS

    Surg Sci   Vol. 3 ( 5 ) page: 237 - 241   2012.5

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  124. リンパ浮腫を伴う絞扼輪症候群における術後リンパ流の検討 Reviewed

    Sakakibara Shunsuke, Ogawa Haruo, Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    日本形成外科学会会誌   Vol. 32 ( 5号 ) page: 352   2012.5

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  125. 粒子線治療に伴う難治性皮膚潰瘍の検討 Reviewed

    Shibaoka Mie, Terashi Hiroto, Hashikawa Kazunobu, Tahara Shinya

    形成外科   Vol. 55 ( 5号 ) page: 527 - 537   2012.5

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  126. 糖尿病性足潰瘍におけるカンジダ性骨髄炎の1例 Reviewed

    Sakakibara Shunsuke, Terashi Hiroto, Hashikawa Kazunobu, Tahara Shinya

    日本形成外科学会会誌   Vol. 32 ( 5号 ) page: 354   2012.5

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  127. 広頸筋皮弁と頸部島状皮弁の口腔再建における適応と問題点

    横尾 聡, 高山 優, 牧口 貴哉, 宮崎 英隆, 古森 孝英, 橋川 和信, 寺師 浩人, 田原 真也

    頭頸部癌   Vol. 38 ( 2 ) page: 196 - 196   2012.5

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  128. 顎口腔領域の広範囲欠損に対する遊離腹直筋皮弁と遊離腓骨皮弁によるdouble free flap reconstruction

    牧口 貴哉, 宮崎 英隆, 小川 将, 高山 優, 橋川 和信, 寺師 浩人, 古森 孝英, 田原 真也, 横尾 聡

    頭頸部癌   Vol. 38 ( 2 ) page: 198 - 198   2012.5

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  129. Novel theory for surgical reconstruction of segmental mandibular defect : CAT concept

    HASHIKAWA Kazunobu, SUGIYAMA Daisuke, YOKOO Satoshi, TAHARA Shinya

      Vol. 38 ( 1 ) page: 84 - 89   2012.4

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  130. がん切除後下顎骨再建における新しい理論「CATコンセプト」(第1報) その概念と妥当性の検討 Reviewed

    Hashikawa Kazunobu, Sugiyama Daisuke, Yokoo Satoshi, Tahara Shinya

    頭頸部癌   Vol. 38 ( 1号 ) page: 84 - 89   2012.4

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  131. NOVEL TREATMENT OF LYMPHORRHEA WITH FLUORESCENT LYMPHOGRAPHY

    Sakakibara Shunsuke, Yuasa Kanako, Terashi Hiroto, Hashikawa Kazunobu, Tahara Shinya

    WOUND REPAIR AND REGENERATION   Vol. 20 ( 1 ) page: A10 - A10   2012

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  132. Novel theory for surgical reconstruction of segmental mandibular defect: CAT concept

    Hashikawa Kazunobu, Sugiyama Daisuke, Yokoo Satoshi, Tahara Shinya

    Toukeibu Gan   Vol. 38 ( 1 ) page: 84 - 89   2012

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    We propose the &ldquo;CAT concept&rdquo;, a new theory for surgical reconstruction after oncological segmental mandibulectomy. The essence of the theory is to reconstruct three reference points on the mandible &mdash;&ldquo;C&rdquo; (condylar head), &ldquo;A&rdquo; (mandibular angle)and &ldquo;T&rdquo; (mental tubercle)&mdash; necessary and sufficient for its surgical reconstruction.<br>An anthropometric analysis of the mandible of ten preserved human cadavers showed that the mandibular contour can be made merely 3 to 7 mm smaller than the original when the CAT concept is adopted, suggesting that the concept sufficiently satisfies the condition for surgical reconstruction of the mandible.<br>A review of our 45 clinical cases of mandibular reconstruction after oncological ablation demonstrated a positive trend between the number of reconstructed or non-resected reference points of the CAT concept and the esthetic outcome of each patient (Fisher's exact test, p<0.01), suggesting that the concept satisfies the necessary condition.<br>Given these results, we concluded that the CAT concept is a highly practical theory for the surgical reconstruction of segmental mandibular defects.

    DOI: 10.5981/jjhnc.38.84

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  133. The Fillet Toe Flap in Toe Amputation

    Sakakibara Shunsuke, Terashi Hiroto, Sakurai Sayuri, Hashikawa Kazunobu, Tahara Shinya

    Japanese Journal of Surgical Wound Care   Vol. 3 ( 3 ) page: 123 - 128   2012

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    Toe amputation for chronic ulcers associated with osteomyelitis or malignant tumor requires additional metatarsal bone resection for covering the stump ; alternatively, the stump is kept raw and skin is grafted after the formation of granulation. The fillet toe flap is one of the options for primary coverage of the stump when the lesion is restricted to half the side of the toe and the digital artery is preserved after the lesion is resected. Minimization of the level of amputation is related to improvements in ADL after surgery. Moreover, because long rest causes disuse atrophy, early healing is desirable. Although the fillet toe flap is used only in special cases, it could be used as a sensory flap. We believe the use of the fillet toe flap deserves more widespread consideration in toe amputation.

    DOI: 10.11310/jsswc.3.123

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  134. Brow Lift via an Infrabrow Approach for Facial Palsy

    HASHIKAWA Kazunobu, SAKAKIBARA Shunsuke

      Vol. 31   page: 136 - 138   2011.12

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  135. True pedicled fibular graft による脛骨遠位骨欠損の再建

    高須 啓之, 寺師 浩人, 橋川 和信, 政岡 浩輔, 田原 真也

    日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery   Vol. 31 ( 10 ) page: 716 - 720   2011.10

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  136. True pedicled fibular graftによる脛骨遠位骨欠損の再建 Reviewed

    Terashi Hiroto, Hashikawa Kazunobu, Tahara Shinya

    日本形成外科学会会誌   Vol. 31巻, 10号, pp. 716-720   2011.10

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  137. 縦隔炎・胸骨骨髄炎においてデブリードマンの範囲決定にMRIは有効か? Reviewed

    Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya

    日本形成外科学会会誌   Vol. 31巻, 10号, pp. 725-725   2011.10

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  138. 頭皮からの分層植皮術におけるわれわれの工夫 Reviewed

    Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya

    日本形成外科学会会誌   Vol. 31巻, 10号, pp. 729-729   2011.10

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  139. The Elementary Analysis by X-ray Fluorescense : An Examination of Implant on Upper Eyelid

    SAKAKIBARA Shunsuke, HASHIKAWA Kazunobu, SUGIMOTO Isao, KAJITA Satoru, TAHARA Shinya

      Vol. 27 ( 3 ) page: 292 - 296   2011.9

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  140. がん切除後下顎骨再建術における新しい概念 CATコンセプト

    Hashikawa Kazunobu

    日本口腔外科学会雑誌   Vol. 57巻, Suppl., pp. 96-96   2011.9

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  141. 下顎プレート再建での合併症への対応 プレート除去を伴う場合

    Furudoi Shungo, Hashikawa Kazunobu

    日本口腔外科学会雑誌   Vol. 57巻, Suppl., pp. 216-216   2011.9

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  142. 蛍光X線分析法による微量元素解析 上眼瞼インプラントの解析より Reviewed

    Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 27巻, 3号, pp. 292-296   2011.9

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  143. 顎口腔再建におけるフェーズコントラスト型CT Angiographyの有用性について

    Hashikawa Kazunobu, Furudoi Shungo, Shibuya Yasuyuki

    日本口腔外科学会雑誌   Vol. 57巻, Suppl., pp. 215-215   2011.9

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  144. 頭頸部free flap連続200例を対象とした血栓形成危険因子の検討

    牧口 貴哉, 橋川 和信, 宮崎 英隆, 根岸 明秀, 寺師 浩人, 丹生 健一, 田原 真也, 横尾 聡

    The Kitakanto Medical Journal   Vol. 61 ( 3 ) page: 462 - 462   2011.8

  145. Super-microsurgeryトレーニング用血管モデルの開発 リアルさへのこだわり Reviewed

    Hashikawa Kazunobu, Sakakibara Shunsuke, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 24巻, 2号, pp. 179-179   2011.7

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  146. マイクロサージャリーに有用な画像診断学の進歩

    Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 24巻, 2号, pp. 83-83   2011.7

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  147. リンパ浮腫患者のリンパ管組織構造の一考察 Reviewed

    Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 24巻, 2号, pp. 196-196   2011.7

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  148. 基礎疾患のある患者に対するマイクロサージャリー 頭頸部へのfree flap移植術における吻合部血栓のリスク因子について 同一施設連続症例を対象とする患者因子の検討 Reviewed

    Hashikawa Kazunobu, Sakakibara Shunsuke, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 24巻, 2号, pp. 66-66   2011.7

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  149. 新しい皮弁血流モニター法 INVOS:無侵襲混合血酸素飽和度監視装置を用いて(第2報) Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 24巻, 2号, pp. 168-168   2011.7

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  150. 脛骨遠位骨欠損再建におけるTrue pedicled fibular graftの有用性 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 24巻, 2号, pp. 135-136   2011.7

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  151. 術中の血管吻合前に、動的皮膚組織灌流圧(dynamic skin perfusion pressure:d-SPP)を測定して、吻合方法を選択した3症例 Reviewed

    Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 24巻, 2号, pp. 195-195   2011.7

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  152. 高張塩溶液脱細胞化法による脱細胞化神経とその評価

    Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 24巻, 2号, pp. 120-121   2011.7

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  153. 高張塩溶液脱細胞化法による脱細胞化血管の開発とその評価 Reviewed

    Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 24巻, 2号, pp. 117-117   2011.7

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  154. Oral candidiasis mimicking tongue cancer Reviewed

    Tomohisa Shibata, Daisuke Yamashita, Shingo Hasegawa, Miki Saito, Naoki Otsuki, Kazunobu Hashikawa, Shinya Tahara, Ken-ichi Nibu

    AURIS NASUS LARYNX   Vol. 38 ( 3 ) page: 418 - 420   2011.6

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    Candida species inhabit the mucosal surfaces of healthy individuals. Major forms of oral candidiasis are pseudomembranous and atrophic form, but chronic hyperplastic candidiasis (CHC) is rarely seen. We encountered a nodule caused by candidal infection on a forearm flap in the oral cavity mimicking a recurrent tongue cancer, which revealed as CHC by histopathological examination. Like other forms of oral candidiasis, the nodule well responded to the treatment of antifungal agents and eventually disappeared: When an intraoral nodule is observed, the possibility of CHC should be taken into consideration. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.anl.2010.11.007

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  155. 下顎骨再建術におけるイノベーション CAT分類・CATコンセプト Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 27巻, 2号, pp. 141-141   2011.6

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  156. がん切除後下顎骨再建における指標「CATコンセプト」 多施設症例データに基づく検証 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    頭頸部癌   Vol. 37巻, 2号, pp. 262-262   2011.5

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  157. 上顎再建 整容的改善への挑戦 がん切除後上顎・眼窩再建に対する神戸大学の治療タクティクス Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    頭頸部癌   Vol. 37巻, 2号, pp. 177-177   2011.5

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  158. 舌癌切除後の前腕皮弁による再建術後に著明な内頸静脈、外頸静脈血栓を認め、皮弁壊死となった1例 Reviewed

    Hashikawa Kazunobu, Sakakibara Shunsuke, Tahara Shinya

    日本形成外科学会会誌   Vol. 31巻, 3号, pp. 205-205   2011.3

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  159. 仙尾骨・皮膚全層欠損に対して両側 hatchet 型大殿筋皮弁による再建を行った1例

    田村 亮介, 牧口 貴哉, 橋川 和信, 寺師 浩人, 田原 真也

    日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery   Vol. 31 ( 1 ) page: 43 - 46   2011.1

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  160. 仙尾骨・皮膚全層欠損に対して両側hatchet型大臀筋皮弁による再建を行った1例 Reviewed

    Hashikawa Kazunobu

    日本形成外科学会会誌   Vol. 31巻, 1号, pp. 43-46   2011.1

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  161. 形成外科領域におけるMR-Microscopyの有用性

    Hashikawa Kazunobu

    日本形成外科学会会誌   Vol. 31巻, 1号, pp. 69-69   2011.1

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  162. 順行性有茎腓骨弁により脛骨遠位の再建を行った1例

    Hashikawa Kazunobu

    日本形成外科学会会誌   Vol. 31巻, 1号, pp. 65-65   2011.1

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  163. A Modified Transmetatarsal Amputation Reviewed

    Hiroto Terashi, Ikuro Kitano, Yoriko Tsuji, Kazunobu Hashikawa, Shinya Tahara

    JOURNAL OF FOOT & ANKLE SURGERY   Vol. 50 ( 4 ) page: 441 - 444   2011

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    The incidence of the diabetic foot is increasing worldwide. Because evidence has shown that transmetatarsal amputation is associated with fewer failures in amputations of the diabetic foot with or without peripheral arterial disease, improving its management and surgical technique is a mission for the surgeon. Conventional transmetatarsal amputation has held firm, however, for more than 150 years. With a new concept for the transmetatarsal amputation method aimed at a better outcome, we propose a modified procedure for preserving the soft tissue between the metatarsal bones (the vasculature complex with the muscles, periostea, and vessels) and applying it to the distal bone stumps. The purpose of this method is to secure a functional foot by preserving the longitudinal arch. The new method was applied to 11 patients with diabetes mellitus or peripheral arterial disease, or both. All wounds closed successfully. Of the 11 patients, 8 were still alive with no complications. Of these 8 patients, 6 were able to ambulate with a custom-made shoe and 2 used a wheelchair, just as preoperatively. Of the 3 patients who died, 1 died a natural death, 1 died of sepsis, and 1 of cerebral infarction. We believe that the modified transmetatarsal amputation that we have described in this report is a potential breakthrough in the care of patients with forefoot gangrene and may gain acceptance over time. (C) 2011 by the American College of Foot and Ankle Surgeons. All rights reserved.

    DOI: 10.1053/j.jfas.2011.03.018

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  164. Iliac Cancellous Bone Graft for Orbital Floor Reconstruction:in Surgery of Orbital Blowout Fracture

    Hashikawa Kazunobu, Sakakibara Shunsuke, Terashi Hiroto, Tahara Shinya

    Japanese Journal of Surgical Wound Care   Vol. 2 ( 3 ) page: 97 - 103   2011

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    Various grafts with autogenous bone, cartilage, and alloplastic substitutes have been used for orbital floor reconstruction in surgery of facial fractures. Nevertheless, none has been the gold standard of graft material. We have demonstrated good clinical results in cases of pure blowout fracture in which the orbital floor was reconstructed with iliac cancellous bone sheets used as graft material. Here, we detail our surgical technique for orbital floor reconstruction with iliac cancellous bone.<br> The outline of our procedure is as follows:<br> 1)to approach the orbital floor, mainly the subciliary incision is used,<br> 2)the orbital content herniating into the maxillary sinus is repositioned, and the fracture and defect site are exposed subperiosteally,<br> 3)a bone block, a few millimeters thick, is harvested from the inner aspect of the ileum,<br> 4)the cortical bone of the harvested block is burred away and thinned to about a 1 mm-thick cancellous bone sheet,<br> 5)the sheet can be adequately trimmed with surgical scissors,<br> 6)the sheet is placed onto the orbital floor to cover the defect, without any fixation.<br> The iliac cancellous bone graft is as pliable and flexible as to fit the delicate curve of the orbital floor, and as soft as to cut easily with surgical scissors. We consider it the most appropriate material for orbital reconstruction.

    DOI: 10.11310/jsswc.2.97

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  165. 顔面神経麻痺に対する顔面&mdash;舌下神経クロスリンク手術と術後リハビリテーション

    橋川 和信, 榊原 俊介, 田原 真也

    日本マイクロサージャリー学会会誌   Vol. 24 ( 3 ) page: 267 - 274   2011

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    Weakness, hypertonicity, loss of isolated control and/or synkinetic movement of the facial mimetic muscle are common sequelae after facial palsy, unlike disruption of nerve continuity as in Bell's palsy or Hunt's syndrome. Here we describe a surgical procedure and postsurgical rehabilitation for the treatment of such sequelae.<BR>The surgical procedure comprises facial and hypoglossal nerve cross-linking that connects the nerves by an interpositional nerve graft with end-to-side anastomosis. For postsurgical physical rehabilitation, patients are instructed in the following techniques for facial neuromuscular retraining: 1) to practice isolated facial motion in front of a mirror (mirror-biofeedback technique); 2) to avoid gross voluntary movement both during practice and in daily life; and 3) to frequently massage and stretch the affected facial muscle.<BR>Between December 2005 and May 2008, twenty patients with sequelae after facial palsy were treated by our rehabilitation technique. Sixteen patients showed improvement in abnormal facial movement, while four did not. None of the patients developed facial synkinesis associated with tongue motion. Our surgical procedure and postsurgical rehabilitation exercises are alternative techniques for the sequelae of facial palsy.

    DOI: 10.11270/jjsrm.24.267

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  166. リンパ管蛍光造影法によるリンパ漏の評価・治療 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本創傷治癒学会プログラム・抄録集40回   Vol. 巻, , pp. 68-68   2010.12

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  167. 肘部骨露出創を有茎知覚付き皮弁で再建したのちに完全知覚再獲得がなされた症例の経験

    Hashikawa Kazunobu, Tahara Shinya

    日本形成外科学会会誌   Vol. 30巻, 11号, pp. 639-639   2010.11

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  168. 仙尾骨・皮膚全層欠損の治療経験

    田村 亮介, 橋川 和信, 牧口 貴哉, 寺師 浩人, 田原 真也

    日本形成外科学会会誌   Vol. 30 ( 11 ) page: 634 - 634   2010.11

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  169. Validity and utility of CAT classification system for oncological mandibular defects : A multi-institutional study

    HASHIKAWA Kazunobu, SUGIYAMA Daisuke, YOKOO Satoshi, HYODO Ikuo, MOTOMURA Hisashi, KUBO Tateki, KURITA Tomoyuki, YOSHIMOTO Seiichi, TAKUSHIMA Akihiko, YAMASHITA Tetsuro, SAKURABA Minoru, YAGIHARA Kazuhiro, NAKAGAWA Masahiro, YANO Tomoyuki, ISHIDA Katsuhiro, SAKURAI Hiroyuki, TERAO Yasunobu, TANAKA Katsumi, KIMATA Yoshihiro, TAHARA Shinya

    Toukeibu Gan   Vol. 36 ( 3 ) page: 309 - 315   2010.10

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    <i>Background:</i> We have previously proposed the CAT classification system, a simple and clear-cut system for classifying segmental mandibular defects after oncological surgery: &ldquo;C&rdquo; refers to the loss of the condylar head of the mandible, &ldquo;A&rdquo; the mandibular angle and &ldquo;T&rdquo; the mental tubercle. Here, we report a statistical and mathematical taxonomical study on the validity and utility of the classification system.<br><i>Methods:</i> Data were collected from 17 medical institutions in Japan on 259 patients who had undergone surgical ablation and simultaneous microsurgical oromandibular reconstruction (osteocutaneous free flap or soft tissue free flap with reconstruction-plate) attributed to head and neck cancer. The mandibular defects were classified according to the CAT system and the two commonly used systems HCL and Urken, and the validity and utility of the CAT system were tested as follows: 1) the tendency among the numbers of the three reference points of the CAT system (C, A and T) and the esthetic outcome of each patient were analyzed by Jonckheere's trend test, 2) each of the classified patterns of the three systems was analyzed by cluster analysis based on the esthetic results using Ward's method.<br><i>Results:</i> 1) There was a statistically significant trend among the numbers of the three reference points in the CAT system and the esthetic outcome, 2) each of the grouped clusters in the CAT system was clinically explicable and demonstrated a significant difference in the esthetic outcome; the two other systems did not yield such information.<br><i>Conclusion:</i> The CAT classification system is valid and useful for oncological segmental mandibular defects.

    DOI: 10.5981/jjhnc.36.309

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  170. がん切除後下顎骨区域欠損の新しい分類法「CAT分類」(第2報) 妥当性と有用性の検証 Reviewed

    Hashikawa Kazunobu, Sugiyama Daisuke, Tahara Shinya

    頭頸部癌   Vol. 36巻, 3号, pp. 309-315   2010.10

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  171. 外傷後無眼球症の二次的義眼床変形に対するfree flapの適応について 眼瞼皮膚、眼窩骨に欠損がない症例の検討 Reviewed

    橋川 和信, 櫻井 沙由理, 高須 啓之, Terashi Hiroto, 田原 真也

    創傷   Vol. 1 ( 3号 ) page: 119 - 124   2010.10

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  172. A Simplest Method of Flap Monitoring Reviewed

    Shunsuke Sakakibara, Kazunobu Hashikawa, Makoto Omori, Hiroto Terashi, Shinya Tahara

    JOURNAL OF RECONSTRUCTIVE MICROSURGERY   Vol. 26 ( 7 ) page: 433 - 434   2010.9

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    DOI: 10.1055/s-0030-1251562

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  173. 下顎骨再建における再建プレート露出予防法 Wrap-Around法とRun-Through法

    Hashikawa Kazunobu

    日本口腔外科学会雑誌   Vol. 56巻, Suppl., pp. 98-98   2010.9

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  174. 再建プレートを用いた下顎再建症例における術後合併症の検討

    Furudoi Shungo, Shibuya Yasuyuki, Hashikawa Kazunobu

    日本口腔外科学会雑誌   Vol. 56巻, Suppl., pp. 98-98   2010.9

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  175. 口腔癌手術における嚥下改善手術に関する臨床的検討

    Hashikawa Kazunobu, Furudoi Shungo, Shibuya Yasuyuki

    日本口腔外科学会雑誌   Vol. 56巻, Suppl., pp. 140-140   2010.9

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  176. 舌癌切除の前腕皮弁再建術後に著明な内頸・外頸静脈血栓を認め皮弁壊死となった1例

    Hashikawa Kazunobu, Furudoi Shungo

    日本口腔外科学会雑誌   Vol. 56巻, Suppl., pp. 191-191   2010.9

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  177. Blowing ratio as an evaluation tool for velopharyngeal function after oral and oropharyngeal cancer resection. Reviewed International journal

    Chieri Katoh, Miki Saitoh, Miki Tsuneyuki, Hitoshi Tanimoto, Kazunobu Hashikawa, Shinya Tahara, Naoki Otsuki, Ken-ichi Nibu

    Head & neck   Vol. 32 ( 8 ) page: 1012 - 1018   2010.8

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    BACKGROUND: Our objective was to evaluate the value of the blowing test to measure the speech and swallowing function after resection of oral or oropharyngeal cancer. METHODS: Speech and swallowing functions of the patients after surgical resection of oral or oropharyngeal cancer were assessed by a speech intelligibility test, blowing time, questionnaires, and oropharyngeal pressures. Blowing time (pressure) ratio was determined by dividing blowing time (pressure) with open nose by blowing time (pressure) with closed nose. RESULTS: Blowing time ratio had significant correlation with blowing pressure ratio (p = .014), score of speech intelligibility test (p = .0014), questionnaire for aspiration (p = .029), nasopharyngeal backflow (CC = 0.676, p = .032), amount of food to swallow (p = .037), and oropharyngeal pressure during swallowing (p = .024). CONCLUSION: The present results demonstrated the value of blowing time ratio as a simple objective tool for speech and swallowing ability related to velopharyngeal function after resection of oral and oropharyngeal cancers.

    DOI: 10.1002/hed.21283

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  178. A Dyeing Procedure for the Excision of Congenital Auricular Sinuses

    TAMURA Ryosuke, MAKIGUCHI Takaya, HASHIKAWA Kazunobu, SAKAKIBARA Syunsuke, TERASHI Hiroto, TAHARA Shinya

      Vol. 26 ( 2 ) page: 81 - 84   2010.6

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  179. PVAハイドロゲル製微小血管モデルを用いる微小血管端側吻合のトレーニング/シミュレーション Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 26巻, 2号, pp. 223-223   2010.6

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  180. うっ血を生じた足背部逆行性皮弁に対し静脈吻合を付加して皮弁生着に成功した2症例 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 23巻, 2号, pp. 167-167   2010.6

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  181. 下顎区域切除後のプレート再建に関する一考察 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 23巻, 2号, pp. 118-118   2010.6

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  182. ポリビニルアルコール(PVA)ゲルで作製した新しい吻合練習用微小血管モデルの使用経験 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 23巻, 2号, pp. 106-107   2010.6

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  183. 再建プレートで下顎骨を再建する際のプレート露出予防法 wrap-around法とrun-through法 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 26巻, 2号, pp. 159-159   2010.6

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  184. 皮弁血糖値測定による皮弁血流のモニタリング

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 23巻, 2号, pp. 179-179   2010.6

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  185. 新世代の吻合練習用微小血管モデル EXSURG.Microvascular Model 使用経験

    Hashikawa Kazunobu

    日本マイクロサージャリー学会会誌   Vol. 23巻, 2号, pp. 91-91   2010.6

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  186. 新しい脱細胞化技術による代替小口径血管・末梢神経の開発 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 23巻, 2号, pp. 153-153   2010.6

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  187. 手関節部での橈骨動脈の走行に破格を認めた1症例

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 23巻, 2号, pp. 120-120   2010.6

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  188. 蛍光X線分光法による微量元素解析(第2報) Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 26巻, 2号, pp. 190-191   2010.6

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  189. 0.5mm径PVAハイドロゲル製血管モデルを用いるスーパーマイクロサージャリーのトレーニング Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    頭頸部癌   Vol. 36巻, 2号, pp. 181-181   2010.5

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  190. がん切除後下顎骨再建における指標「CATコンセプト」 その概念と保存屍体を用いた検討 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    頭頸部癌   Vol. 36巻, 2号, pp. 198-198   2010.5

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  191. Haemodynamic changes in the fingers after free radial forearm flap transfer: a prospective study using SPP

    Akira Yanagisawa, Kazunobu Hashikawa, Daisuke Sugiyama, Takaya Makiguchi, Hideyuki Yanagi, Shunichi Kumagai, Satoshi Yokoo, Hiroto Terashi, Shinya Tahara

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   Vol. 63 ( 3 ) page: 539 - 543   2010.3

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    Harvesting the radial forearm flap may cause circulatory problems in the donor arm. To investigate the influence on donor hands after radial forearm flap harvesting, we assessed the process of circulatory changes prospectively by measuring skin perfusion pressure (SPP) that is clinically useful in detecting vascular lesions.
    The records of 17 patients (14 men and 3 women aged 59.7 +/- 11.8 years) who had undergone free radial forearm flap transfer for head and neck reconstruction, between December 2005 and April 2007, were analysed. SPP in the thumb (finger I), the middle finger (III) and the little finger (V) was measured in the 17 patients preoperatively and 1 month and 3, 6, 9 and 12 months postoperatively. All statistical tests were two sided, with a significance level defined as p &lt; 0.05.
    Preoperatively, baseline SPP was more dominant in finger I than in finger V. Postoperatively, SPP changed significantly in both fingers, while it showed no change in finger III and tended to be higher in finger I than in the other two.
    Harvesting the free radial forearm flap reduces skin perfusion in the fingers of the donor arm and, we assume, leads to a re-distribution of blood flow to the fingers, with the residual ulnar artery still supplying more blood flow to finger I than to finger V. This suggests the presence of an autoregulating mechanism whereby blood perfusion to the fingers is controlled by the physiological demands of individual fingers. (C) 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bjps.2008.11.068

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  192. Trace Elementary Analysis of Fillers and Implants by X-ray Fluorescence

    KAJITA Satoru, SAKAKIBARA Shunsuke, SUGIMOTO Isao, HASHIKAWA Kazunobu, TAHARA Shinya

      Vol. 30 ( 1 ) page: 1 - 5   2010.1

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  193. Facial-Hypoglossal Nerve Cross-Link Surgery for Involuntary Eye Closure with Tongue Movement as a Sequela of Hunt's Syndrome : A Case Report

    HASHIKAWA Kazunobu, SAKAKIBARA Shunsuke, ISHIDA Yasuhisa

      Vol. 29   page: 93 - 96   2010.1

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  194. 舌と眼瞼の病的共同運動が顔面-舌下神経クロスリンク手術により軽快した顔面神経不全麻痺症例の経験 Reviewed

    Hashikawa Kazunobu

    Facial Nerve Research   Vol. 29巻, , pp. 93-96   2010.1

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  195. 蛍光X線分析装置を用いたフィラー・インプラントの微量元素分析 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本形成外科学会会誌   Vol. 30巻, 1号, pp. 1-5   2010.1

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  196. NEW ACELLULAR SCALP DERMIS TO MAKE EX-VIVO PRODUCED SKIN EQUIVALENT WITH HAIR FOLLICLES

    Terashi H., Sakakibara S., Hasegawa M., Makiguchi T., Hashikawa K., Tahara S., Yamaoka T., Mahara A., Fujisato T.

    WOUND REPAIR AND REGENERATION   Vol. 18 ( 1 ) page: A4 - A4   2010

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  197. Free Flap Transfer for Secondary Deformity of Post-traumatic Anophthalmic Orbit without Eyelid / orbital Bone Defect

    Hashikawa Kazunobu, Sakurai Sayuri, Takasu Hiroyuki, Terashi Hiroto, Tahara Shinya

    Japanese Journal of Surgical Wound Care   Vol. 1 ( 3 ) page: 119 - 124   2010

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    In the treatment of secondary deformities of anophthalmic orbits after severe trauma, free flap transfer is adopted for patients with eyelid and / or orbital rim defects. For some, however, free flap transfer is a requisite although no such defects are present. Here, we retrospectively review cases for which free flap transfer was carried out for secondary deformities of post-traumatic anophthalmic orbits without eyelid / orbital bone defects. From 1999 to 2008, seven patients with secondary deformities of post-traumatic anophthalmic orbits without eyelid or orbital bone defects were treated at Kobe University Hospital. Of the seven, three were treated with free flap transfers: two with a free forearm flap because of the inability to wear an eye prosthesis subsequent to the sudden onset of severe contracture of the eye socket, and one with a denuded DIEP flap for upper eyelid depression attributed to severe lack of and contracture of subcutaneous tissue. Even when the eyelid and the orbital bone are not injured, progressive contraction of the eye socket and severe lack of subcutaneous tissue are indications for free flap transfer in the treatment of secondary deformities of post-traumatic anophthalmic orbits.

    DOI: 10.11310/jsswc.1.119

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  198. Cross-sectional analysis of Quality-of-Life of patients undergoing reconstructive surgery for tongue cancer

    YOSHIMOTO Seiichi, KIMATA Yasuhiro, KURITA Tomoyuki, HASHIKAWA Kazunobu, ISHIDA Katsudai, SAKURABA Minoru, SAKURAI Hiroyuki, TANAKA Katsumi, YANO Tomoyuki, HYODO Ikuo

    Toukeibu Gan   Vol. 35 ( 4 ) page: 374 - 379   2009.12

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    Organs with important functions for daily life are concentrated in the head and neck area, and maintaining post-treatment Quality-of-Life (QOL) is also important when treating cancers of the head and neck, in addition to improving survival rate. Free flap reconstruction techniques are expected to contribute to maintaining post-treatment QOL, but these techniques have not been adequately evaluated in Japan. We performed a cross-sectional analysis of QOL, using the Japanese version of the UWQOL (version 4) from the University of Washington in the United States, with 202 patients from 10 institutions who had undergone reconstructive surgery for tongue cancer. In addition to the survey form, we collected clinical information (age, sex, time since surgery, flap donor site, whether radiotherapy was administered, and other factors), and analyzed whether differences in postoperative QOL were seen depending on each of these factors and the hospital at which the surgery was performed. Although a relationship was found between QOL following reconstructive surgery for tongue cancer and the extent of resection, age and whether radiotherapy was administered, fairly good QOL was maintained overall.

    DOI: 10.5981/jjhnc.35.374

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  199. 【キズアトをいかにきれいにするか scarless wound healingのために】手術による瘢痕の治療 瘢痕を少なくする縫合法と縫合糸の選択

    牧口 貴哉, 橋川 和信, 田原 真也

    PEPARS   ( 35 ) page: 1 - 7   2009.11

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    縫合糸や皮膚閉鎖に用いる材料の特性を十分に理解することは'キズアトをきれいにする'ために重要である。たとえ縫合技術が一流であっても、材料に対する理解が不十分であれば良好な結果を得ることはできない。瘢痕形成を考慮すると、組織反応が少なく、抗張力の持続するモノフィラミント合成非吸収糸であるナイロン糸を用いた真皮縫合が主流であった。しかし近年、長期間抗張力を維持する吸収糸が開発され、真皮縫合に使用される機会が増えてきた。長期的な縫合糸膿瘍、糸露出の危険性を考慮すると、PDS IIなどの抗張力の持続するモノフィラメントの合成吸収糸は有用である。真皮縫合の後、創縁の微妙な修正やズレの防止のために、縫合糸を用いた表皮縫合を行う。皮下縫合、真皮縫合で創縁がしっかりと外反、密着している状態では、表皮縫合をせずに皮膚表面接着剤、サージカルテープや半透過性透明フイルムも(1)抜糸の必要がない、(2)針糸刺入による組織損傷がない、(3)手術時間の短縮が可能、(4)縫合糸痕の心配がない、という点で有用な皮膚閉鎖法である。本稿では、真皮縫合に用いる縫合糸の選択および表皮縫合の方法について詳述する。(著者抄録)

  200. Internal Jugular Vein Thrombosis After Microsurgical Reconstruction in the Head and Neck Region

    YANAGISAWA Akira, HASHIKAWA Kazunobu, YOKOO Satoshi, TERASHI Hiroto, TAHARA Shinya

      Vol. 22 ( 3 ) page: 258 - 265   2009.9

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  201. 上顎歯肉癌切除後の広範欠損にAbbe-Estlander flapと前腕皮弁による再建を行った一例 Reviewed

    Furudoi Shungo, Hashikawa Kazunobu, Shibuya Yasuyuki

    日本口腔外科学会雑誌   Vol. 55巻, Suppl., pp. 146-146   2009.9

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  202. 新しい下顎骨区域欠損分類法 CAT分類 Reviewed

    Hashikawa Kazunobu

    日本口腔外科学会雑誌   Vol. 55巻, Suppl., pp. 125-125   2009.9

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  203. 褥瘡滲出液中に含まれるタンパク質を考える(中間報告) 慢性創傷のモデルとして Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本褥瘡学会誌   Vol. 11巻, 3号, pp. 333-333   2009.8

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  204. 心房細動が頭頸部Free Flapにおける吻合部血栓に与える影響 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 22巻, 2号, pp. 170-170   2009.6

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  205. 神経の変則的縫合術 移植床神経による筋(皮)弁の「再支配」 ラットモデルを用いた脱神経萎縮防止効果の検討 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 22巻, 2号, pp. 92-93   2009.6

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  206. 神経の変則的縫合術 神経トレーサーを用いる神経回路解析実験におけるわれわれの工夫 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 22巻, 2号, pp. 90-90   2009.6

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  207. 懸垂状を呈した後頭骨骨腫の1例 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 25巻, 2号, pp. 171-171   2009.6

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  208. 遊離皮弁による頭蓋底悪性腫瘍切除後再建 `Step-Surgery Concept'を用いて Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 22巻, 2号, pp. 145-145   2009.6

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  209. 頭頸部腫瘍切除後の二次再建 頭頸部腫瘍切除後の二次的義眼床形成再建手術 治療戦略と問題点 Reviewed

    Hashikawa Kazunobu, Ichinose Akihiro, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 25巻, 2号, pp. 100-101   2009.6

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  210. 頭頸部Free Flap連続250例を対象とした血栓形成危険因子の検討 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 25巻, 2号, pp. 124-125   2009.6

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  211. 遊離皮弁による頭頸部再建術後の内頸静脈血栓症 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 22巻, 2号, pp. 169-169   2009.6

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  212. 顔面神経麻痺の後療法 顔面神経-舌下神経クロスリンク手術の術後リハビリテーション Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 22巻, 2号, pp. 84-85   2009.6

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  213. 顔面部に用いられるフィラーの蛍光X線分析法による微量元素分析 Reviewed

    Sugimoto Isao, Sakakibara Shunsuke, Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 25巻, 2号, pp. 168-168   2009.6

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  214. Reconstruction of the Orbital Floor With Sheets of Autogenous Iliac Cancellous Bone Reviewed

    Shunsuke Sakakibara, Kazunobu Hashikawa, Hiroto Terashi, Shinya Tabara

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY   Vol. 67 ( 5 ) page: 957 - 961   2009.5

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    Purpose: Various autografts and synthetic materials such as titanium plates have been used for orbital floor reconstruction; however, no consensus on reconstruction methods has been reached. We have used iliac cancellous bone for this reconstruction with good results.
    Patients and Methods: Patients (n = 101) enrolled in this study underwent orbital floor reconstruction of pure blowout fracture with an approximate I mm thinned and trimmed iliac cancellous bone without fixation of the graft. The results were assessed by CT; diplopia exceeding an angle of 45 degrees was evaluated as a poor outcome.
    Results: Postoperatively, diplopia appeared in 15 patients and disappeared in 86 patients. At 6-month follow-up, CT showed that the morphology of the orbit was well maintained and no shedding or improper positioning of the grafted bone was observed in any of the patients. Moreover, CT images demonstrated ossification of the transplanted bone graft.
    Conclusions: The method encompassing the use of the medulla of the iliac bone has several merits: 1) the graft bone is sufficiently pliable and flexible to fit the gently curving orbital floor; 2) being soft, it is easy to cut. Furthermore, no complication attributable to its fragility is observed at short- and long-term follow-up. The I mm thin medullar bone graft derives its robustness from its beamed structure. We consider the medulla of the iliac bone fitting autosomal material for the reconstruction of the orbital floor. (C) 2009 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 67:957-961, 2009

    DOI: 10.1016/j.joms.2008.08.014

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    PubMed

  215. がん切除後下顎骨欠損の新しい分類法「CAT分類」 (第2報)有用性と妥当性の検証 Reviewed

    Hashikawa Kazunobu, Sugiyama Daisuke, Tahara Shinya

    頭頸部癌   Vol. 35巻, 2号, pp. 110-110   2009.5

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  216. A case of low-grade myofibroblastic sarcoma of the maxilla

    MURATA Maho, UMEDA Masahiro, NISHI Chikako, HASHIKAWA Kazunobu, USAMI Yu, KOMORI Takahide

    Japanese Journal of Oral and Maxillofacial Surgery   Vol. 55 ( 4 ) page: 184 - 188   2009.4

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    Low-grade myofibroblastic sarcoma is an uncommon neoplasm of atypical myofibroblasts with fibromatosis-like features. The lesion has only been characterized in the last two decades, and the concept of neoplastic myofibroblasts remains controversial. We encountered a patient with low-grade myofibroblastic sarcoma of the maxilla.<br>A 70-year-old woman was referred to our hospital because of swelling of the anterior maxilla. She had undergone repeated surgical procedures of the lesion at other hospitals. The tumor invaded the hard palate, nasal cavity, bilateral maxillary sinus, and cheek skin. The biopsy specimen showed a low-grade myofibroblastic sarcoma, and she underwent wide resection of the lesion and reconstructive surgery using a free forearm flap. Histologic examination revealed diffuse, fascicular proliferation of spindle cells with focal cellular atypia. The tumor cells showed positive reactions for α-SMA and vimentin, which indicated differentiation to myofibroblasts, and the lesion was diagnosed as a low-grade myofibroblastic sarcoma. The patient is free from tumor 13 months after surgery.

    DOI: 10.5794/jjoms.55.184

    CiNii Article

  217. Assessment of shapes of ischia with pressure ulcers

    Makiguchi T., Terashi H., Hashikawa K., Tamura R., Tahara S.

    Japanese Journal of Plastic Surgery   Vol. 52 ( 4 ) page: 445 - 450   2009.4

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    The process of the ischium may be a risk factor for intractable pressure ulcers, as is the process of the sacrum. How the ischium affects pressure ulcers is the subject of controversy, however, because little is known about the shapes of ischia with pressure ulcers. With 3-dimensional computed tomography (3D-CT), we assessed the extent of the prominence of the ischium and free bone fragments of eight patients with ischial ulcers who required surgery. In 6 out of 9 patients (67 %) the ischia of the side with pressure ulcers were less prominent than, and in 3 patients ischial bones of the side with pressure ulcers were as prominent as, the other side, demonstrating that in no case is the ischium of the side with the pressure ulcer more prominent than the other side. In the sitting position, the pelvis tends to lean toward the side of the less prominent ischium. Ischial pressure ulcers may be intractable because of the leaning, which increases interface pressure on the side of the pressure ulcer.

    Scopus

  218. 上顎に発生した低悪性型筋線維芽細胞肉腫の1例 Reviewed

    Murata Maho, Umeda Masahiro, Hashikawa Kazunobu, Komori Takahide

    日本口腔外科学会雑誌   Vol. 55巻, 4号, pp. 184-188   2009.4

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  219. 坐骨部褥瘡における骨形態の評価 Reviewed

    Hashikawa Kazunobu

    形成外科   Vol. 52巻, 4号, pp. 445-450   2009.4

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  220. Simple Reconstruction of Subtotal Maxillectomy Defects Using Free Flaps

    NOMURA Tadashi, NONOMURA Hideaki, EJIRI Hirotaka, UOZUMI Masaki, HASHIMOTO Dai, HASHIKAWA Kazunobu, TAHARA Shinya

      Vol. 25 ( 1 ) page: 60 - 67   2009.3

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  221. Two cases of antegrade venous anastomosis employed on distally-based flap from dorsal foot

    Ogawa H., Nomura T., Ejiri H., Ito K., Hashikawa K., Tahara S.

    Japanese Journal of Plastic Surgery   Vol. 52 ( 3 ) page: 325 - 331   2009.3

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    When a surgeon treats a distal foot ulcer accompanying exposure of the bone or joint, reverse flow flap from the dorsal foot is a useful maneuver to employ. Reverse flow flaps are very useful for the reconstruction of distal extremities; however, venous congestion of the flap may occur. Although various theories of reverse venous drainage have been reported, the safety and certainty of reverse flow flap have not been verified. In this report, we use the reverse flow flap from the dorsal foot to treat distal foot ulcers. We performed venous anastomosis to persuade postoperative venous drainage antegradely. We present two case reports and discuss the reliability of venous anastomosis in reverse flow flap surgery.

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  222. 同一創部における合成吸収糸:polydioxanone糸と合成非吸収糸:ナイロン糸の瘢痕比較 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    瘢痕・ケロイド治療ジャーナル   Vol. 巻, 3号, pp. 45-48   2009.3

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  223. 第2足趾移植により再建した指末節periosteal chondromaの1例 Reviewed

    Hashikawa Kazunobu, Sugimoto Isao

    日本形成外科学会会誌   Vol. 29巻, 3号, pp. 185-186   2009.3

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  224. 手に発生した静脈奇形に対する硬化療法 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本手の外科学会雑誌   Vol. 26巻, 1号, pp. S146-S146   2009.3

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  225. 心房細動が頭頸部free flapにおける吻合部血栓に与える影響 Reviewed

    Hashikawa Kazunobu

    日本形成外科学会会誌   Vol. 29巻, 3号, pp. 209-209   2009.3

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  226. 術前放射線化学療法併用直腸癌Miles手術後に創部潰瘍を生じた症例の治療経験 Reviewed

    Hashikawa Kazunobu

    日本形成外科学会会誌   Vol. 29巻, 3号, pp. 184-184   2009.3

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  227. 長期安静保持を必要とする難治性潰瘍患者の静脈血栓塞栓症(VTE)予防について Reviewed

    Hashikawa Kazunobu

    日本形成外科学会会誌   Vol. 29巻, 3号, pp. 205-205   2009.3

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  228. Surgical Procedures in Static Reconstruction for Facial Palsy

    HASHIKAWA Kazunobu, SAKAKIBARA Shunsuke, ICHINOSE Akihiro

      Vol. 28   page: 114 - 119   2009.2

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  229. Neural Circuit Analysis with Neural Tracer on Rat Model of Cross-Link Nerve Grafting between Facial and Hypoglossal Nerve

    SAKAKIBARA Shunsuke, ISHIDA Yasuhisa, HASHIKAWA Kazunobu

      Vol. 28   page: 48 - 50   2009.2

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  230. 陳旧性顔面神経麻痺の静的形成手術における神戸大学の取り組み Reviewed

    Hashikawa Kazunobu, Sakakibara Shunsuke, Ichinose Akihiro

    Facial Nerve Research   Vol. 28巻, , pp. 114-119   2009.2

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  231. 順行性神経トレーサー法による神経回路解析 顔面-舌下神経cross-link手術をモデルとして Reviewed

    Sakakibara Shunsuke, Hashikawa Kazunobu

    Facial Nerve Research   Vol. 28巻, , pp. 48-50   2009.2

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  232. New acellular scalp dermis to make ex-vivo produced skin equivalent with hair follicles

    Terashi H., Yokoo S., Sakakibara S., Hashikawa K., Kurata S., Sunagawa T., Makiguchi T., Fujisato T., Itami S., Hasegawa M., Tahara S.

    WOUND REPAIR AND REGENERATION   Vol. 17 ( 1 ) page: A7 - A7   2009

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  233. Brill Bit Breakage During Fixation of Facial Bone

    KONISHI Kazuhito, HASHIKAWA Kazunobu, SAKAKIBARA Shunsuke, OHMORI Makoto, TAHARA Shinya

      Vol. 24 ( 4 ) page: 245 - 251   2008.12

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  234. A Case of Distal Venous Arterialization for Ischemic Hand

    ISHIDA Yasuhisa, HASHIKAWA Kazunobu, NAGATA Ikuko, TERASHI Hiroto, TAHARA Shinya

      Vol. 21 ( 4 ) page: 438 - 442   2008.12

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  235. 超高静水圧処理法によるヒト頭皮由来無細胞真皮作製 男性型脱毛症の再生外科的治療法へのステップ

    Hashikawa Kazunobu, Tahara Shinya

    日本創傷治癒学会プログラム・抄録集38回   Vol. 巻, , pp. 49-49   2008.12

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  236. 手指壊疽に対するDistal Venous Arterializationの経験 Reviewed

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 21巻, 4号, pp. 438-442   2008.12

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  237. 顔面骨骨折整復固定時のドリル破折症例に関する検討 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 24巻, 4号, pp. 245-251   2008.12

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  238. Novel classification system for oncological mandibular defect : CAT classification

    HASHIKAWA Kazunobu, YOKOO Satoshi, TAHARA Shinya

      Vol. 34 ( 3 ) page: 412 - 418   2008.10

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  239. Selection of operative methods for decubitus on calcaneal region

    Terashi H., Tsuji Y., Hashikawa K., Fujii M., Okumura K., Kitano I.

    Japanese Journal of Plastic Surgery   Vol. 51 ( 10 ) page: 1173 - 1182   2008.10

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    We have to reconsider the selection of operative methods for decubitus on calcaneal regions, unlike the reconstructive operative methods for the loading region on feet. This is because it depends upon the pathogenesis of decubitus, sensory level, and/or ambulatory condition whether the wound has the operative indication. We here classify the decubitus on calcaneal region into three patterns. 1. Bedfast patient 2. Diabetes mellitus (DM) and/or peripheral arterial disease (PAD) 3. Ambulatory paralytic patient.

    Scopus

  240. 下顎骨再建のupdate 腫瘍切除後の一次下顎再建における治療指針の確立 がん切除後下顎骨区域欠損の新しい分類法「CAT分類」(第1報) その概念と分類の実際 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    頭頸部癌   Vol. 34巻, 3号, pp. 412-418   2008.10

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  241. 神戸大学口腔外科における口底再建の工夫

    Furudoi Shungo, Shibuya Yasuyuki, Hashikawa Kazunobu, Tahara Shinya

    日本口腔腫瘍学会誌   Vol. 20巻, 3号, pp. 204-204   2008.9

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  242. 口腔癌広範切除後の早期気管孔閉鎖は必ずしも必要ではない レティナ装着を組み入れた口腔癌広範切除症例の標準治療

    Furudoi Shungo, Shibuya Yasuyuki, Hashikawa Kazunobu, Tahara Shinya

    日本口腔科学会雑誌   Vol. 57巻, 3号, pp. 362-362   2008.7

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  243. マイクロサージャリーの基本手技血管吻合 神戸大学形成外科における基本的な微小血管吻合法 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 21巻, 2号, pp. 117-117   2008.6

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  244. 先天性耳瘻管摘出術における瘻管染色の工夫 Reviewed

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 24巻, 2号, pp. 84-85   2008.6

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  245. 眉間部に発生したOsteolipomaの1例 発生起序を脂肪腫由来幹細胞の分化能の観点から推察 Reviewed

    Terashi Hiroto, Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 24巻, 2号, pp. 102-102   2008.6

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  246. 内視鏡下経鼻腔的整復術(EER)は眼窩内側壁骨折治療の標準的術式となり得るか Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 24巻, 2号, pp. 116-116   2008.6

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  247. 術後車椅子、自動車運転座席、便座における接触圧評価を行った坐骨部褥瘡の1症例 Reviewed

    Terashi Hiroto, Hashikawa Kazunobu, Tahara Shinya

    日本褥瘡学会誌   Vol. 10巻, 2号, pp. 136-142   2008.6

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  248. 頭頸部free flap連続200例を対象とした血栓形成危険因子の検討 メタボリックシンドロームは危険因子か?

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 21巻, 2号, pp. 189-190   2008.6

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  249. 顔面pseudolymphomaの一例 Reviewed

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 24巻, 2号, pp. 106-106   2008.6

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  250. 顔面神経-舌下神経クロスリンク手術(仮)は顔面病的共同運動に対する治療法となり得るか?

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 21巻, 2号, pp. 144-144   2008.6

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  251. 顔面に生じたSpitz母斑の2症例 Reviewed

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    日本頭蓋顎顔面外科学会誌   Vol. 24巻, 2号, pp. 104-105   2008.6

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  252. Sclerotherapy for venous malformations; evaluation of simulation cavenography based on our classification of circulation of venous malformation

    Nagata I., Sakurai A., Nomura T., Kenmoku K., Makiguchi T., Hashikawa K., Terashi H., Tahara S.

    Japanese Journal of Plastic Surgery   Vol. 51 ( 5 ) page: 555 - 560   2008.5

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    Sclerotherapy for venous malformation is thought to be a simple, relatively safe, minimally invasive treatment that leaves no scars. Its effectiveness has often been reported, and it is the standard treatment in Japan. Here, we investigated the usefulness of simulation cavernography and sclerotherapy for venous malformation. We retrospectively analyzed 80 sclerotherapy sessions of 42 patients diagnosed with venous malformation and treated by sclerotherapy at Kobe University Hospital and in the Division of Plastic Surgery, National Hospital Organization Himeji Medical Center, from April 2000 to October 2006. The results of fluoroscopy were classified into four types according to the following procedures. Type I : Pooling of contrast medium in the cavity of the venous malformation was confirmed, and sclerotherapy was conducted continuously (50 sessions, 62.5%). Type II : A thick drainage vein was confirmed, another part was punctured, and sclerotherapy was conducted continuously (8 sessions, 10.0%). Type IIIa : A thick drainage vein was confirmed, and sclerotherapy was carried out by manually pressing the vein to prevent the sclerosant from flowing into the drainage vein (21 sessions, 26.3%). Type IIIb : A thick drainage vein was confirmed, another part was punctured, but sclerotherapy was discontinued (1 session, 1.25%). Had we carried out sclerotherapy without simulation cavernography, some side effects would probably have ensued in 37.5% of the cases. The results suggest that simulation cavernography and sclerotherapy are useful in the treatment of venous malformation.

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  253. 下顎骨再建のupdate 腫瘍切除後の一次下顎再建における治療指針の確立 がん切除後下顎骨欠損の分類法について 新しい分類法「CAT分類」の提案 Reviewed

    Hashikawa Kazunobu, Tahara Shinya

    頭頸部癌   Vol. 34巻, 2号, pp. 132-132   2008.5

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  254. 神戸大学における悪性腫瘍切除後の遊離皮弁による頭蓋底一次再建 Reviewed

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    頭頸部癌   Vol. 34巻, 2号, pp. 153-153   2008.5

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  255. 静脈奇形に対する硬化療法 術中透視下病変造影の重要性 Reviewed

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    形成外科   Vol. 51巻, 5号, pp. 555-560   2008.5

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  256. A Retrospective Statistical Analysis of Hypopigmentation after Q-Switched Ruby / Alexandrite Laser Irradiation for Aberrant Mongolian Spot

    NAGATA Ikuko, SUGIMOTO Isao, HASHIKAWA Kazunobu, TERASHI Hiroto, SUGIYAMA Daisuke, KUMAGAI Syunichi, TAHARA Shinya

    Nippon Laser Igakkaishi   Vol. 29 ( 1 ) page: 26 - 29   2008.4

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    Publisher:Japan Society for Laser Surgery and Medicine  

    Q-switched lasers, developed on the theory of selective photothermolysis, are effective in the treatment of dermal melanocytosis; however, any incidental complications can cause considerable anxiety.<BR>A retrospective study on hypopigmentation was carried out on 53 regions of 42 patients undergoing treatment for aberrant mongolian spots after Q-switched laser irradiation, between July 2000 and June 2006 at the Department of Plastic Surgery, Kobe University Graduate School of Medicine. The association between patient factors (age, gender; region of irradiation - trunk, extremity - type of laser, fluence of energy, and frequency of laser irradiation) and hypopigmentation after laser irradiation was examined by multiple logistic regression analysis. Twenty-four cases (45.3%) exhibited hypopigmentation. Treatment on the trunk was associated with a greater incidence of hypopigmentation than treatment at extremities (odds ratio: 16.257,[95%CI, 2.367-111.660],P=0.005). Patient factors of age, gender, type of laser, fluence of energy, and frequency of laser irradiation were not statistically significant. These results are worthy of discussion and need to be verified from multiple aspects.

    DOI: 10.2530/jslsm.29.26

    CiNii Article

  257. 異所性蒙古斑のレーザー治療後色素脱失に関する統計学的検討 Reviewed

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    日本レーザー医学会誌   Vol. 29巻, 1号, pp. 26-29   2008.4

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  258. 豊胸術後多発皮下硬結の治療経験

    藤井 美樹, 橋川 和信, 杉本 庸, 田原 真也, 杉本 孝郎

    日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery   Vol. 28 ( 3 ) page: 147 - 151   2008.3

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  259. Anterograde Labeling for Hypoglossal Nerve

    SAKAKIBARA Shunsuke, HASHIKAWA Kazunobu, ISHIDA Yasuhisa, NAGATA Ikuko, OMORI Makoto, TERASHI Hiroto, TAHARA Shinya

      Vol. 21 ( 1 ) page: 28 - 32   2008.3

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  260. 神戸大学におけるケロイド切除後の電子線治療の方法と成績 Reviewed

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    瘢痕・ケロイド治療ジャーナル   Vol. 巻, 2号, pp. 103-106   2008.3

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  261. 順行性トレーサー法による舌下神経染色法 Reviewed

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    日本マイクロサージャリー学会会誌   Vol. 21巻, 1号, pp. 28-32   2008.3

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  262. Curious complication after oroesophageal reconstruction with free jejunal flap: Intrussusception-like deformity of transferred jejunum Reviewed

    Shunsuke Sakakibara, Shinya Tahara, Kazunobu Hashikawa, Ken-ichi Nibu

    JOURNAL OF RECONSTRUCTIVE MICROSURGERY   Vol. 24 ( 2 ) page: 89 - 92   2008.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:THIEME MEDICAL PUBL INC  

    Regions of oropharyngeal cancer, hypopharyngeal cancer, and cervical esophageal cancer in a 70-year-old man were surgically resected and reconstructed with a free jejunal flap. Postoperatively the patient showed severe dysphagia and a chimneylike protrusion in the oral cavity. In a second operation, a dorsal, longitudinal incision for phimosis was made to release the stenosis; however, the dysphagia persisted, and peristalis seemed to interfere with deglutition. Here, we discuss the cause of the dysphagia, a complication of total reconstruction of oroesophageal defects with a single free jejunal flap, and the procedures of reconstruction.

    DOI: 10.1055/s-2008-1076092

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    PubMed

  263. FACIAL-HYPOGLOSSAL NERVE "CROSS-LINK" WITH INTERPOSITIONAL GREAT AURICULAR NERVE JUMP GRAFT FOR INVOLUNTARY EYE CLOSURE AS A SEQUELA OF BELL'S PALSY

    HASHIKAWA Kazunobu

    Facial N Res Jpn   Vol. 27   page: 192 - 195   2008.1

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  264. Simultaneous Application of Percutaneous Monitoring Angiography and Sclerotherapy for Venous Malformation

    SAKURAI Atsushi, NOMURA Tadashi, NAGATA Ikuko, MAKIGUCHI Takaya, HASHIKAWA Kazunobu, TERASHI Hiroto, TAHARA Shinya

      Vol. 15 ( 4 ) page: 91 - 94   2008.1

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  265. Anatomical Analysis of the Length of Levator Aponeurosis in Asian Cadavers

    MIZUGUCHI Kei, HASHIKAWA Kazunobu, ICHINOSE Akihiro, TERASHI Hiroto, TAHARA Shinya

      Vol. 28 ( 1 ) page: 9 - 12   2008.1

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  266. Jump graft型顔面-舌下神経クロスリンク手術により不随意閉瞼が改善した顔面病的共同運動2例の経験 Reviewed

    Hashikawa Kazunobu

    Facial Nerve Research   Vol. 27巻, , pp. 192-195   2008.1

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  267. 血管奇形硬化療法における術中シミュレーション 静脈奇形症例についての検討

    櫻井 敦, 野村 正, 永田 育子, 牧口 貴哉, 橋川 和信, 寺師 浩人, 田原 真也

    日本シミュレーション外科学会会誌   Vol. 15 ( 4 ) page: 91 - 94   2008.1

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    血管奇形に対する硬化療法に術中シミュレーションを導入し、その成績を報告した。対象は静脈奇形に対して硬化療法を施行し、造影記録を確認できた15症例(男性7名、女性8名)で、これらの症例に対して合計33回の治療を行った。術中シミュレーションの結果は以下の4タイプに分類した。造影剤が病変内に留まり、そのまま硬化療法を施行した症例(タイプ1,82%)。太い流出静脈や主要血管への流出が確認され、穿刺部位を変えて硬化療法を施行した症例(タイプ2,15%)。用手的圧迫で病変内に留まり、硬化療法を施行した症例(タイプ3a,0%)。用手的圧迫でも病変内に留まらず、硬化療法を断念した症例(タイプ3b,3%)。タイプ3aは硬化療法施行時にしばしば経験するが、今回の症例中では見られなかった。タイプ2と3bを併せると18%の症例で流出静脈を認めたが、いずれの症例も重篤な合併症は見られず、経過は良好であった。

  268. Hybrid treatment for critical limb ischemia using skin perfusion pressure (SPP) as wound care management similar to Ten cases report

    Nagata I, Terashi H., Hashikawa K., Tsuji Y., Kitano I, Tahara S.

    WOUND REPAIR AND REGENERATION   Vol. 16 ( 1 ) page: A6 - A6   2008

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  269. Novel classification system for oncological mandibular defect: CAT classification

    Hashikawa Kazunobu, Yokoo Satoshi, Tahara Shinya

    Toukeibu Gan   Vol. 34 ( 3 ) page: 412 - 418   2008

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    We propose a new classification system for segmental mandibular defects after oncological ablative surgery. The system describes a mandibular defect with three letters - C, A and T -. &ldquo;C&rdquo; reflects loss of the condylar head of mandible, &ldquo;A&rdquo; the mandibular angle and &ldquo;T&rdquo; the mental tubercle. The defect is classified as &ldquo;A&rdquo; when the mandibular angle is segmentally resected, as &ldquo;CA&rdquo; when the condylar head and the mandibular angle are resected, as &ldquo;CAT&rdquo; when the entire hemi-mandible is resected, as &ldquo;ATT&rdquo; when the angle and the bilateral mental tubercle are resected, as &ldquo;body&rdquo; when only the mandibular body is resected and the angle and the mental tubercle are preserved, and as &ldquo;neck&rdquo; when only the mandibular ramus is resected and the condylar head and the angle are preserved. This CAT classification system is simple, clear-cut, and a new alternative for oncological mandibular defects.

    DOI: 10.5981/jjhnc.34.412

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  270. Auricular cartilage graft for lower lid retraction in thyroid ophthalmopathy; "CLIC" comprehensive lid interlining cartilage graft

    Hashikawa K., Tsuji Y., Azumi A., Terashi H., Tahara S.

    Japanese Journal of Plastic and Reconstructive Surgery   Vol. 50 ( 12 ) page: 1447 - 1453   2007.12

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    We describe two cases of hemilateral lower lid retraction in thyroid ophthalmopathy surgically treated with comprehensive lid interlining cartilage (CLIC) grafts, whereby the total lower lid is supported by 4.5×1 cm auricular cartilage. Case 1 : A 74-year-old man visited our department presenting with right lower lid retraction (4 mm lower than the contralateral side), The patient had three months earlier undergone right inferior rectus muscle recession to treat double vision. A CLIC graft to his right lower lid was carried out under local anesthesia. Case 2 : A 44-year-old man with right lower lid retraction (3 mm lower than the contralateral side) had 12 months earlier undergone right inferior rectus muscle recession. The patient underwent a CLIC graft under general anesthesia. In both cases, the retracted lower lid was corrected and restored to the level of the contralateral side I also, a natural symmetrical appearance of the mid-face was attained. CLIC grafting is an effective alternative treatment for lower lid retraction in thyroid ophthalmopathy patients.

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  271. 毛髪付き培養複合皮膚作製へ向けて ヒト頭皮由来無細胞真皮作製

    寺師 浩人, 横尾 聡, 榊原 俊介, 橋川 和信, 倉田 荘太郎, 砂川 武, 牧口 貴哉, 藤里 俊哉, 板見 智, 長谷川 真澄, 田原 真也

    日本創傷治癒学会プログラム・抄録集   Vol. 37回   page: 55 - 55   2007.12

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  272. 口腔内に移植した遊離前腕皮弁に対するレーザー脱毛の経験

    武川 力, 橋川 和信, 杉本 庸, 寺師 浩人, 田原 真也

    日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery   Vol. 27 ( 11 ) page: 770 - 773   2007.11

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  273. Thin minigrafting technique for postburn leukoderma

    Miki Fujii, Hiroto Terashi, Kazunobu Hashikawa, Tadashi Nomura, Makoto Omori, Shinya Tahara

    DERMATOLOGIC SURGERY   Vol. 33 ( 11 ) page: 1368 - 1373   2007.11

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    DOI: 10.1111/j.1524-4725.2007.33294.x

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  274. Dynamic SPP(仮)が血行動態評価に有用であった重症虚血肢症例の経験

    Hashikawa Kazunobu

    日本シミュレーション外科学会会誌   Vol. 15巻, 3号, pp. 66-66   2007.9

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  275. Simple dressing technique using polyurethane foam for fixation of skin grafts

    Atsushi Sakurai, Kazunobu Hashikawa, Satoshi Yokoo, Hiroto Terashi, Shinya Tahara

    DERMATOLOGIC SURGERY   Vol. 33 ( 8 ) page: 976 - 979   2007.8

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    DOI: 10.1111/j.1524-4725.2007.33202.x

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  276. Thrombosis in Anastomosed Vein with Suspected Involvement of Deep Vein Thrombosis

    NARUSE Hidemi, HASHIKAWA Kazunobu, TSUJI Yoriko, KEMMOKU Kazutaka, EJIRI Hirotaka, YOKOO Satoshi, TAHARA Shinya

      Vol. 20 ( 2 ) page: 147 - 152   2007.6

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  277. Free scalp flapを用いた踵部潰瘍の治療経験

    Hashikawa Kazunobu

    日本マイクロサージャリー学会会誌   Vol. 20巻, 2号, pp. 251-251   2007.6

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  278. Therapeutic strategy for the triad of acquired anophthalmic orbit

    Hashikawa Kazunobu, Terashi Hiroto, Tahara Shinya

    PLASTIC AND RECONSTRUCTIVE SURGERY   Vol. 119 ( 7 ) page: 2182 - 2188   2007.6

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    BACKGROUND: In treating patients with anophthalmic orbits, it is essential to achieve a long-lasting natural appearance and comfortable retention of eye prostheses. In 1992, the authors developed a therapeutic strategy based on a simple algorithm for treating the three common symptoms of acquired anophthalmic orbit: severe eye socket contracture is surgically treated with a radial forearm free flap transfer, upper lid depression is treated with lipoinjection, and lower lid retraction is treated with an auricular cartilage graft. METHODS: From 1992 to 2004, 18 acquired anophthalmic orbits (11 enucleated and seven exenterated) were treated at Kobe University Hospital based on the authors' therapeutic strategy. Aesthetic outcomes were evaluated according to patient and surgeon satisfaction. RESULTS: Sixteen patients underwent auricular cartilage grafts, eight received radial forearm free flap transfers, and seven were treated with lipoinjection. Optional revisional surgery was carried out in four cases. The aesthetic outcome was assessed as good in six patients, moderate in eight patients, and poor in four patients; the last four had undergone total maxillectomy with orbital exenteration or had eyelid defects because of previous cancer surgery. CONCLUSIONS: The authors' therapeutic strategy for acquired anophthalmic orbit is simple and, with slight modification, fitting for most cases, although it necessitates innovative surgery in cases with orbital rim and/or eyelid defects. ©2007American Society of Plastic Surgeons.

    DOI: 10.1097/01.prs.0000260706.07368.f1

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  279. ブローアウト骨折の眼窩底再建におけるわれわれの工夫 腸骨髄質骨プレートの有用性

    Hashikawa Kazunobu

    日本頭蓋顎顔面外科学会誌   Vol. 23巻, 2号, pp. 87-87   2007.6

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  280. 下顎再建に用いられた血管柄付き遊離腓骨の術後骨吸収についての統計学的検討

    Hashikawa Kazunobu

    日本頭蓋顎顔面外科学会誌   Vol. 23巻, 2号, pp. 118-118   2007.6

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  281. 下口唇有棘細胞癌切除後一期的再建方法(Free composite graftとOne-stage lip-switch flapの臨床的比較)

    Hashikawa Kazunobu

    日本頭蓋顎顔面外科学会誌   Vol. 23巻, 2号, pp. 160-160   2007.6

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  282. 口腔内に移植した遊離前腕皮弁に対するレーザー脱毛の経験

    Hashikawa Kazunobu

    日本頭蓋顎顔面外科学会誌   Vol. 23巻, 2号, pp. 126-126   2007.6

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  283. 眼窩下壁ブローアウト骨折の手術治療までの期間と手術成績

    Hashikawa Kazunobu

    日本頭蓋顎顔面外科学会誌   Vol. 23巻, 2号, pp. 86-86   2007.6

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  284. 甲状腺眼症の下眼瞼後退に対する耳介軟骨移植の経験 Comprehensive Lid Interlining Cartilage:CLIC法

    Hashikawa Kazunobu

    日本頭蓋顎顔面外科学会誌   Vol. 23巻, 2号, pp. 108-108   2007.6

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  285. 深部静脈血栓症との関連が疑われた吻合部血栓の経験 Reviewed

    Hashikawa Kazunobu

    日本マイクロサージャリー学会会誌   Vol. 20巻, 2号, pp. 147-152   2007.6

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  286. 当院における肝動脈血行再建術

    Hashikawa Kazunobu

    日本マイクロサージャリー学会会誌   Vol. 20巻, 2号, pp. 191-191   2007.6

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  287. 遊離前腕皮弁採取による手部血行の変化 皮膚灌流圧(SPP)測定による検討

    Hashikawa Kazunobu

    日本マイクロサージャリー学会会誌   Vol. 20巻, 2号, pp. 245-245   2007.6

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  288. 遊離前腕皮弁移植における神戸大学の取り組み

    Hashikawa Kazunobu

    日本マイクロサージャリー学会会誌   Vol. 20巻, 2号, pp. 244-244   2007.6

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  289. 顔面再建における神戸大学の治療戦略 遊離皮弁移植と二次修正を組み合わせる再建法の評価と適応の検討

    Hashikawa Kazunobu

    日本マイクロサージャリー学会会誌   Vol. 20巻, 2号, pp. 188-188   2007.6

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  290. 頭頸部free flap連続200例を対象とした血栓形成危険因子の検討 メタボリックシンドロームは危険因子か?

    Hashikawa Kazunobu

    頭頸部癌   Vol. 33巻, 2号, pp. 159-159   2007.5

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  291. 頭頸部再建 Conventional flap vs.Perforator flap 頭頸部再建におけるconventional flap、とくに前腕皮弁のreliabilityとversatilityについて

    Hashikawa Kazunobu

    頭頸部癌   Vol. 33巻, 2号, pp. 80-80   2007.5

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  292. Problems of Microsurgical Arterial Reconstruction in Adult Living Donor Liver Transplants

    SAKAKIBARA Shunsuke, HASHIKAWA Kazunobu, TAHARA Shinya

      Vol. 20 ( 1 ) page: 71 - 76   2007.3

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  293. Step-Surgery Concept : An Alternative Reconstructive Strategy for Full-Thickness Facial Defect

    HASHIKAWA Kazunobu, TERASHI Hiroto, YOKOO Satoshi, YANAGI Hideyuki, TAHARA Shinya

      Vol. 20 ( 1 ) page: 46 - 53   2007.3

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  294. Congenital melanocytic nevi and nevus spilus have a tendency to follow the lines of Blaschko: An examination of 200 cases

    Hiromi Hanayama, Hiroto Terashi, Kazunobu Hashikawa, Shinya Tahara

    JOURNAL OF DERMATOLOGY   Vol. 34 ( 3 ) page: 159 - 163   2007.3

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    There have been few reports about the characteristics of the pigmentary arrangement of congenital melanocytic nevi (CMN) and nevus spilus (NS). Though the lines of Blaschko, which don't correspond to other lines such as Langer's lines and skin dermatomes, are well known to be followed by some rare pigmentary disorders, the relationship between these two disorders and the lines of Blaschko has not been discussed. Therefore, through an examination of 200 cases, we investigated whether or not the arrangement of CMN and NS follow the lines of Blaschko. Thirty-nine out of 92 cases (42.4%) of CMN and 67 out of 108 cases (62.0%) of NS were considered to follow the lines of Blaschko. Today, the idea is widely accepted that two functionally different cells proliferate during early embryogenesis of the skin which is caused from mosaicism and, as a result, the lines of Blaschko appear visually. In our results, we found that there were some cases of CMN and NS which showed a relationship with the lines of Blaschko, which is meaningful considering that the lesions and the lines are both related to pigmentary gene anomalies. The result was compared with CMN and NS by the chi(2) test. NS showed a predominant tendency to follow the lines with a significant difference (P = 0.0055). This may indicate that the lines of Blaschko reflect more clearly the proliferation of the epidermal cells than other cells in growth of the skin of the embryo. Further studies are required to elucidate the reason why some cases follow these lines and others do not.

    DOI: 10.1111/j.1346-8138.2007.00242.x

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  295. 顔面の全層欠損に対する再建戦略 Step-Surgery Concept Reviewed

    HASHIKAWA KAZUNOBU, TERASHI HIROTO, TAHARA SHINYA

    日本マイクロサージャリー学会会誌   Vol. 20巻, 1号, pp. 46-53   2007.3

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  296. Functional reconstruction of large anogenital defects with bilateral V-Y advancement posterior thigh fasciocutaneous flaps Reviewed

    Miki Fujii, Hiroto Terashi, Kazunobu Hashikawa, Shinya Tahara

    JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY   Vol. 60 ( 11 ) page: 1208 - 1213   2007

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCI LTD  

    Background: In patients with perianal extramammary Paget's disease, wide local A excision is recommended. In the reconstruction of the resulting large defects not only the closure of the defect but also the preservation of anogenital function need to be considered.
    Methods: We used bilateral V-Y advancement posterior thigh fasciocutaneous flaps for reconstructing three large anogenital defects, including the total anal canal, resulting from wide tocal excisions attributed to extramammary Paget's disease. A temporary anus was constructed at the same time to allow the wound of the reconstructed anus to heal. After the surgery, the course of bowel function was followed up through interviews and manometric examinations.
    Results: All defects were successfully reconstructed with the flaps, and bowel function recovered satisfactorily. Manometric examinations were carried out in two cases; anal pressures were recorded regularly and used as parameters of the recovery of bowel function before closing the artificial anus. Eventually, the patients recovered the function of defecation.
    Conclusions: We recommend the bilateral V-Y advancement posterior thigh fasciocutaneous flaps together with manometric studies as one of the most effective techniques for managing large anogenital defects. The use of sensate flaps, the restoration of original structures and manometric studies are conducive to successful outcomes. (C) 2007 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bjps.2007.02.005

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  297. Traumatic Lacrimal Canaliculi Injury ; Experience of Ten Cases

    TERASHI Hiroto, HASHIKAWA Kazunobu, TAHARA Shinya

      Vol. 22 ( 3 ) page: 203 - 208   2006.12

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  298. Simultaneous Percutaneous Monitoring Angiography in Sclerotherapy for Venous Malformation

    SAKURAI Atsushi

      Vol. 14 ( 2 )   2006.11

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  299. REFINEMENT OF SURGICAL PROCEDURES IN RADIAL FOREARM FREE FLAP TRANSFER

    HASHIKAWA Kazunobu, TERASHI Hiroto, TAHARA Shinya

      Vol. 32 ( 3 ) page: 247 - 252   2006.10

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  300. 仙骨部褥瘡に対する外科的療法の適応基準化と周術期管理方法に関する一考察 神戸大学形成外科専門医アンケート調査 Reviewed

    TERASHI HIROTO, HASHIKAWA KAZUNOBU

    日本褥瘡学会誌   Vol. 8巻, 4号, pp. 560-565   2006.10

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  301. 外傷性涙小管断裂の10例 Reviewed

    TERASHI HIROTO, HASHIKAWA KAZUNOBU

    日本頭蓋顎顔面外科学会誌   Vol. 22巻, 3号, pp. 203-208   2006.9

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  302. Our Screening Trial for Body Dysmorphic Disorders in Plastic Surgery Patients

    SATO Makoto, NAGATA Ikuko, HASHIKAWA Kazunobu, ICHINOSE Akihiro, TAHARA Shinya

      Vol. 26 ( 8 ) page: 518 - 524   2006.8

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  303. 身体醜形障害を疑う患者に対する当科での取り組み Reviewed

    HASHIKAWA KAZUNOBU, ICHINOSE AKIHIRO

    日本形成外科学会会誌   Vol. 26巻, 8号, pp. 518-524   2006.8

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  304. 大腿骨頭壊死に対する遊離腓骨皮弁移植の経験

    柳 英之, 橋川 和信, 塚本 金作, 森 大祐

    日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery   Vol. 26 ( 6 ) page: 403 - 406   2006.6

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  305. Orthognathic surgery for occlusal reconstruction of old malunited jaw fracture

    Yokoo S., Komori T., Furudoi S., Shibuya Y., Tateishi C., Hashikawa K., Tahara S., Hanagaki H.

    Kobe Journal of Medical Sciences   Vol. 52 ( 3 ) page: 37 - 47   2006.6

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    Old malunited jaw fractures of nine patients who underwent orthognathic surgery for occlusal reconstruction were clinically evaluated. Early surgery on fractures of the jaw is the optimal treatment when due attention must be paid to occlusion. Since occlusal revision surgery subsequent to inaccurate diagnosis and inappropriate surgery is certainly very difficult and often unsuccessful, surgeons need to pay special attention to this situation.

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  306. 仙骨部褥瘡に対するrhomboid perforator flapの経験 Reviewed

    HASHIKAWA KAZUNOBU, TERASHI HIROTO

    日本褥瘡学会誌   Vol. 8巻, 2号, pp. 208-211   2006.6

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  307. Simple reconstruction with titanium mesh and radial forearm flap after globe-sparing total maxillectomy: a 5-year follow-up study Reviewed

    Kazunobu Hashikawa, TAHARA, Shinya, ISHIDA, Haruhiko, YOKOO, Satoshi, Toshiaki Sanno, TERASHI, Hiroto, NIBU, Kenichi

    Plastic And Reconstructive Surgery   Vol. 117 ( 3 ) page: 963 - 967   2006.3

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    DOI: 10.1097/01.prs.0000200623.91956.66

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  308. Orthognathic surgery for occlusal reconstruction of old malunited jaw fracture

    Yokoo Satoshi, Komori Takahide, Furudoi Shungo, Shibuya Yasuyuki, Tateishi Chizu, Hashikawa Kazunobu, Tahara Shinya, Hanagaki Hirofumi

    The Kobe journal of the medical sciences   Vol. 52 ( 3 ) page: 37 - 47   2006

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    Publisher:神戸大学  

    Old malunited jaw fractures of nine patients who underwent orthognathic surgeryfor occlusal reconstruction were clinically evaluated. Early surgery on fractures of thejaw is the optimal treatment when due attention must be paid to occlusion. Sinceocclusal revision surgery subsequent to inaccurate diagnosis and inappropriate surgeryis certainly very difficult and often unsuccessful, surgeons need to pay special attentionto this situation.

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  309. Orthognathic surgery for occlusal reconstruction of old malunited jaw fracture.

    Yokoo S, Komori T, Furudoi S, Shibuya Y, Tateishi C, Hashikawa K, Tahara S, Hanagaki H

    The Kobe journal of medical sciences   Vol. 52 ( 3-4 ) page: 37 - 47   2006

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  310. REFINEMENT OF SURGICAL PROCEDURES IN RADIAL FOREARM FREE FLAP TRANSFER

    HASHIKAWA Kazunobu, TERASHI Hiroto, TAHARA Shinya

    Toukeibu Gan   Vol. 32 ( 3 ) page: 247 - 252   2006

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    Publisher:Japan Society for Head and Neck Cancer  

    We have carried out about 600 head and neck reconstructions with radial forearm free flap transfer and basic/clinical studies on flap circulation and surgical procedures. Knowledge obtained and refinement of surgical procedures in flap elevation, venous anastomosis and donor site coverage introduced at Kobe University Hospital are as follows:<BR>1) Deep and superficial venous systems of the flap are connected by including the cubital perforating vein in the venous pedicle.<BR>2) Our studies have revealed that the deep venous system has dominant blood flow compared with the superficial system. Consequently, drainage of the former system is crucial in reducing venous disturbance of the flap.<BR>3) &ldquo;Network venous anastomosis&rdquo;, where the two separate venous systems of the flap are anastomosed with the two venous systems of the neck (the internal and external jugular veins) including their connecting perforating vein, imitates the anatomical venous drainage in the forearm, providing a reliable, fail-safe drainage system.<BR>4) Skin grafts preserving subdermal vascular networks provide aesthetically more optimal results in covering the donor site of the flap.<BR>5) Fixation of skin grafts to the donor site of the flap with polyurethane foam and film without using the tie-over procedure is an easy and time-saving method requiring no assistants.

    DOI: 10.5981/jjhnc.32.247

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  311. Total lower lid support with auricular cartilage graft

    Hashikawa K, Tahara S, Nakahara M, Sanno T, Hanagaki H, Tsuji Y, Terashi H

    PLASTIC AND RECONSTRUCTIVE SURGERY   Vol. 115 ( 3 ) page: 880 - 884   2005.3

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    DOI: 10.1097/01.PRS.0000153233.87258.5D

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  312. Positive narrowing pharyngoplasty with forearm flap for functional restoration after extensive soft palate resection

    Hashikawa K, Tahara S, Terashi H, Ichinose A, Nomura T, Omori M, Sanno T

    PLASTIC AND RECONSTRUCTIVE SURGERY   Vol. 115 ( 2 ) page: 388 - 393   2005.2

  313. E-mail Consultation on Our Web Site

    SUGIMOTO Isao, HASHIKAWA Kazunobu, ICHINOSE Akihiro, TERASHI Hiroto, TAHARA Shinya

      Vol. 24 ( 4 ) page: 226 - 230   2004.4

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  314. Do multiple venous anastomoses reduce risk of thrombosis in free-flap transfer? Efficacy of dual anastomoses of separate venous systems

    Ichinose A, Terashi H, Nakahara M, Sugimoto I, Hashikawa K, Nomura T, Ogata N, Yokoo S, Tahara S

    ANNALS OF PLASTIC SURGERY   Vol. 52 ( 1 ) page: 61 - 63   2004.1

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    Language:Japanese   Publisher:Annals of Plastic Surgery  

    Whether or not multiple venous anastomoses reduce the risk of free-flap failure is a subject of controversy. We report here, for the first time, on the importance of selecting 2 separate venous systems of the flap for dual anastomoses. The efficacy of multiple anastomoses was verified through a retrospective review of 310 cases of the free radial forearm flap transfer. Dual anastomoses of separate venous systems (the superficial and the deep) showed a lower incidence of venous insufficiency than single anastomosis did (0.7% versus 7.5%; P < 0.05). On the other hand, dual anastomoses of a sole venous system showed no significant difference in the incidence of venous insufficiency compared with single anastomosis (11.5% versus 7.5%; P = 0.48). Our results suggest that dual venous anastomoses of separate venous systems is conducive to reduced risk of flap failure and affords protection against venous catastrophe through a self-compensating mechanism that obviates thrombosis of either anastomosis.

    DOI: 10.1097/01.sap.0000096425.18223.60

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  315. Three-dimensional reconstruction after oral oncologic surgery using single free radial forearm flaps or free rectus abdominis musculocutaneous flaps

    Yokoo Satoshi, Komori Takahide, Furudoi Syungo, Umeda Masahiro, Nomura Tadashi, Hashikawa Kazunobu, Ichinose Akihiro, Tahara Shinya

    Journal of Oral Science   Vol. 46 ( 1 ) page: 65 - 70   2004

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    Publisher:日本大学歯学部  

    This study reviews reconstruction of complex three-dimensional oral and maxillofacial defects using the <i>single</i> free radial forearm flap or the <i>single</i> free rectus abdominis musculocutaneous flap. Between 1996 and 2003, 124 patients underwent oral and maxillofacial reconstruction in the Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine. Outcomes for 22 patients who underwent three-dimensional reconstruction of multiple surfaces were evaluated. Reconstruction was performed after resection of malignant tumors in all 22 patients. <i>Single</i> FAFs were utilized for 11 patients and single RAMs for the remaining 11. Flap survival rate was 100%. No major donor morbidity was observed, and all surviving patients (20/22) were able to perform normal daily living activities. <i>Single</i> FAF and RAM are useful materials for one-stage reconstruction of complex three-dimensional oral and maxillofacial defects requiring replacement of skin, mucosa, and intervening soft tissues. Good to excellent aesthetic results can be attained in most patients. (J. Oral Sci. 46, 65-70, 2004)

    DOI: 10.2334/josnusd.46.65

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    CiNii Article

  316. Therapeutic importance of transplantation of a vascularised free flap for an oromandibular injury with infection and severe scar contracture

    Yokoo S, Komori T, Sakurai A, Hashikawa K, Nomura T, Sanno T, Ichinose A, Tahara S

    BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY   Vol. 41 ( 6 ) page: 380 - 382   2003.12

  317. Endoscopic endonasal reduction for blowout fracture of the medial orbital wall

    Sanno T, Tahara S, Nomura T, Hashikawa K

    PLASTIC AND RECONSTRUCTIVE SURGERY   Vol. 112 ( 5 ) page: 1228 - 1237   2003.10

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    Endoscopic endonasal reductions have been addressed in 63 patients with blowout fracture of the medial orbital wall since 1992. The operations were carried out under general anesthesia with a magnified operative space projected on a television monitor by a charge coupled device video camera attached to the endoscope. The middle nasal turbinate was fractured toward the nasal septum, the uncinate process was cut off, and the bulla was opened. The ethmoidal bony partition and the mucous membrane were removed; however, the fractured bone chips of the medial orbital wall were preserved. The herniated orbital contents were pressed back into the orbital cavity, and the medial wall was set with 2-mm-thick bent silicone plates placed in the ethmoidal sinus. The plates were removed in the outpatient clinic 2 months after the operation. The surgical results of 21 patients treated with endoscopic reduction were compared with those of four patients treated with transfacial reduction with an iliac bone graft. All of the patients had isolated medial wall fracture and became aware of diplopia within 15 degrees in any direction from the primary position (straight gaze) before the operation; the follow-up period covered 6 months. The patients were classified into two categories according to postoperative double vision: "good," indicating no double vision or diplopia of more than 45 degrees, and "poor," diplopia of less than 45 degrees. Improvement of diplopia was observed in all patients without any complication. Of the 21 patients who underwent endoscopic reductions, 17 were classified as "good" and four as "poor." On the other hand, of the four patients who underwent transfacial reductions, three were classified as "good" and one as "poor." Significant differences were not observed between the surgical results of our two methods. Endoscopic endonasal reduction showed greater aesthetic advantages and, moreover, required no grafting. This technique is suggested as one of the most reasonable treatments of medial orbital wall fractures.

    DOI: 10.1097/01.PRS.0000080723.29129.64

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  318. Replantation of an avulsed zygomatic bone as a freeze-preserved autologous graft: a case report

    Yokoo S, Tahara S, Sakurai A, Hashikawa K, Terashi H, Furudoi S, Umeda M, Komori T

    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY   Vol. 31 ( 2 ) page: 115 - 119   2003.4

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    Language:Japanese   Publisher:Journal of Cranio-Maxillofacial Surgery  

    We describe a very rare case of midface fracture where the zygomatic bone had been completely avulsed. The fragment was preserved in a frozen state for 40 days, then replanted and the graft was taken. The conditions favourable for the taking of the freeze-preserved zygomatic graft were: (1) an appropriate preservation method, (2) conservation of the periosteum on the zygomatic bone, (3) diversity of the haemodynamics of the zygomatic membranous bone, (4) immobilization of the zygoma by rigid fixation, and (5) a rich blood supply at the recipient site. © 2002 European Association for Cranio-Maxillofacial Surgery.

    DOI: 10.1016/S1010-5182(02)00183-X

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  319. Importance of the deep vein in the drainage of a radial forearm flap: A haemodynamic study

    Ichinose A, Tahara S, Terashi H, Yokoo S, Nakahara M, Hashikawa K, Kenmoku K

    SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY   Vol. 37 ( 3 ) page: 145 - 149   2003

  320. Importance of the deep vein in the drainage of a radial forearm flap: a haemodynamic study.

    Ichinose A, Tahara S, Terashi H, Yokoo S, Nakahara M, Hashikawa K, Kenmoku K

    Scandinavian journal of plastic and reconstructive surgery and hand surgery   Vol. 37 ( 3 ) page: 145 - 9   2003

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  321. Importance of the deep vein in the drainage of a radial forearm flap: A haemodynamic study

    Ichinose A., Tahara S., Terashi H., Yokoo S., Nakahara M., Hashikawa K., Kenmoku K.

    Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery   Vol. 37 ( 3 ) page: 145 - 149   2003

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    Language:Japanese   Publisher:Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery  

    The free radial forearm flap has two drainage veins, the cutaneous and the deep, but no established consensus has been reached on the selection of the drainage pedicle. In our study, the flow volumes of the veins were examined by colour Doppler ultrasonography after 20 forearm flaps had been raised. The volume through the deep vein was significantly higher than that through the cutaneous vein (p < 0.01). In comparing the total flow (both veins open), the flow rate through the deep vein alone (cutaneous vein occluded) was over 80% in 13 cases, 60%-80% in seven, and under 60% in none; that through the cutaneous vein alone (deep vein occluded) was 60%-80% in eight, 40%-60% in eight, under 40% in four, and over 80% in none. Our results show the importance of the deep vein, as indicated by its high drainage capacity from the early stages of flap transfer.

    DOI: 10.1080/2844310310007746

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  322. Devices for facial aesthetic improvement in the treatment of skeletal mandibular protrusion

    Yokoo S, Komori T, Tateishi C, Komurasaki H, Omori M, Hashikawa K, Tahara S

    AESTHETIC PLASTIC SURGERY   Vol. 26 ( 4 ) page: 251 - 254   2002

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    Language:Japanese   Publisher:Aesthetic Plastic Surgery  

    Some techniques for the treatment of mandibular protrusion with consideration for aesthetic improvement of the face as a whole are described. The aesthetic inferiority complex in the mind of patients with masticatory disorders as the chief complaint should not be underestimated. Three techniques were used in this study; preoperative orthodontic treatment, preservation of the patient's self-image, and maintenance of beautiful relationship between the midfacial line and the nasolabial fold as well as the nasal ala.

    DOI: 10.1007/s00266-002-2036-4

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  323. Functional and aesthetic reconstruction of full-thickness cheek, oral commissure and vermilion

    Yokoo S, Tahara S, Tsuji Y, Nomura T, Hashikawa K, Hanagaki H, Furudoi S, Umeda M, Komori T

    JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY   Vol. 29 ( 6 ) page: 344 - 350   2001.12

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    Purpose: This paper presents surgical techniques for reconstruction of the cheek, oral commissure and vermillion in the repair of full-thickness cheek defects after resection of buccal-mucosal squamous cell carcinoma. Patients and Methods: Four reconstructions in one-stage surgery with either a free radial forearm flap or a rectus abdominis musculocutaneous flap for cheek and oral commissure were carried out. There were combined with a new approach for vermillion advancement flaps. Most challenging was the need not only for morphological reconstruction of the orifice, but also for physiological reestablishment of sphincteric and sensory functions in the vermillion. Results: Morphological and physiological reconstruction of the lip with sphincteric and sensory functions was attained. Conclusion: This valuable reconstruction technique was demonstrated in large, full thickness defects involving the cheek, oral commissure and vermilion. © 2001 European Association for Cranio-Maxillofacial Surgery.

    DOI: 10.1054/jcms.2001.0249

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  324. Functional reconstruction of mobile tongue and suprahyoid muscles after resection of cancer of the tongue

    Yokoo S, Komori T, Umeda M, Takenono I, Hashikawa K, Hanagaki H, Tahara S

    BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY   Vol. 39 ( 4 ) page: 252 - 255   2001.8

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  325. Functional reconstruction of mobile tongue and suprahyoid muscles after resection of cancer of the tongue

    Yokoo S., Komori T., Umeda M., Takenono I., Hashikawa K., Hanagaki H., Tahara S.

    British Journal of Oral and Maxillofacial Surgery   Vol. 39 ( 4 ) page: 252 - 255   2001

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    Language:Japanese   Publisher:British Journal of Oral and Maxillofacial Surgery  

    The mobile tongue and the suprahyoid muscles were reconstructed in a man who had had a total resection of the mobile tongue with the oral floor and bilateral radical neck dissection (extensive resection of the bilateral suprahyoid muscles) for cancer of the tongue. A rectus abdominis musculocutaneous flap with the tenth intercostal nerve anastomosed to the remaining hypoglossal nerve was used for the reconstruction. The rectus abdominis muscle was inserted between the mandible and the hyoid bone, taking account of the anatomical positions of the tongue and suprahyoid muscles; the rectus sheath was then firmly sutured to the mandible and hyoid bone. This procedure created firm tendinous insertions between the mandible and hyoid bone. After the operation, the reconstructed tongue showed no sign of atrophy, and the reconstructed suprahyoid muscles (rectus abdominis muscle) could be moved, and the hyoid bone could be raised. © 2001 The British Association of Oral and Maxillofacial Surgeons.

    DOI: 10.1054/bjom.2001.0636

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  326. 冷凍保存された自家頬骨体の移植により整復した頬骨骨折症例の経験

    横尾 聡, 櫻井 淳, 橋川 和信, 山王 俊明, 田原 真也

    日形会誌 : 日本形成外科学会会誌 = Journal of Japan Society of Plastic and Reconstructive Surgery   Vol. 20 ( 12 ) page: 756 - 760   2000.12

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  327. Reliability of the Deep System in Venous Drainage of the Free Radial Forearm Flap

    YOKOO Satoshi, TAHARA Shinya, HASHIKAWA Kazunobu, ICHINOSE Akihiro

      Vol. 20 ( 10 ) page: 597 - 602   2000.10

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  328. Relationship Between the Preoperative Period and the Postsurgical Outcome of a Blowout Fracture

    SANNO Toshiaki, TAHARA Shinya, HASHIKAWA Kazunobu

      Vol. 16 ( 2 ) page: 62 - 65   2000.9

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  329. Role of the Perforating Vein in the Vascular Pedicle of the Free Radial forearm Flap

    YOKOO Satoshi, TAHARA Shinya, HASHIKAWA Kazunobu, SANNO Toshiaki, NAKAHARA Minoru

      Vol. 19 ( 5 ) page: 272 - 276   1999.5

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Books 1

  1. TEXT形成外科学(改訂3版) / 各論I 先天性疾患 I 頭頸部 E. 外鼻

    Hashikawa Kazunobu

    南山堂  2017.3 

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    Language:Japanese Book type:Textbook, survey, introduction

MISC 1

  1. 【顔面神経麻痺の形成外科的治療―最近の話題】舌下神経と顔面神経のクロスリンクによる陳旧性顔面神経不全麻痺の治療 Invited

    Hashikawa Kazunobu

    医学のあゆみ   Vol. 268 ( 10 ) page: 843 - 848   2019

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

Presentations 1

  1. 指神経背側枝を温存した逆行性指動脈皮弁による指尖部再建の経験

    OSAKI TAKEO, TAMURA RYOUSUKE, NOMURA TADASHI, HASHIKAWA KAZUNOBU, TERASHI HIROTO

    第45回日本マイクロサージャリー学会学術集会  2018.12 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪  

KAKENHI (Grants-in-Aid for Scientific Research) 29

  1. 神経線維腫症1型の特性から解明するScarless Wound Healing

    Grant number:21K09763  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    大石 真由美, 新城 恵子, 高成 啓介, 橋川 和信, 蛯沢 克己, 神戸 未来, 樋口 慎一, 山本 周平, 亀井 譲

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    Authorship:Coinvestigator(s) 

    本研究の目的は神経線維腫症1型(NF-1)の創傷治癒から瘢痕抑制のメカニズムを解明し、scarless wound healingを可能とする新規治療薬を開発することである。NF-1では手術後の瘢痕が目立ちにくく、肥厚性瘢痕やケロイドを生じにくいことが経験的に知られているが、NF-1の創傷治癒過程における過剰な瘢痕形成を抑制するメカニズムは明らかではない。現在行われている瘢痕治療の効果は限定的であり、手術や外傷後に傷あとが残ることは不可避であったが、NF-1に特有な創傷治癒メカニズムを再現することで、scarless wound healingの実現を試みる。

  2. Analysis of metastasis and growth of melanoma cells under irradiation of specific light exposure with Gq mutation

    Grant number:20H03849  2020.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\17680000 ( Direct Cost: \13600000 、 Indirect Cost:\4080000 )

  3. Biological analysis of smooth muscle cells in soft tissue vascular malformation

    Grant number:20K09864  2020.4 - 2023.3

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    Authorship:Coinvestigator(s) 

  4. 乳児血管腫におけるstem cellの関与 ~増殖・分化制御機構の解明~

    2018.4 - 2021.3

    学術研究助成基金助成金/基盤研究(C) 

    櫻井 沙由理

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    Grant type:Competitive

  5. 光による皮膚概日リズム形成の意義を探る

    2018.4 - 2021.3

    科学研究費補助金/基盤研究(B) 

    寺師 浩人

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    Grant type:Competitive

  6. 乳児血管腫におけるstem cellの関与 ~増殖・分化制御機構の解明~

    Grant number:18K09481  2018.4 - 2021.3

    大澤

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    Authorship:Coinvestigator(s) 

    乳児の増殖期は,未分化な血管内皮細胞の高度な細胞増殖によって特徴付けられる。一方,退縮期に入ると,血管内皮細胞は徐々に減少して,比較的口径の大きな血管に変化し,それとともに周囲に脂肪組織が増えていく。このような,退縮期での脂肪組織への置換は極めてユニークな生物学的変化であり,このように振る舞う固形腫瘍は存在しない。このIHの主体をなす血管内皮細胞は分化能を有する未分化な細胞から構成されている。このような独自の特徴をもつIHの血管内皮細胞のうち,幹細胞マーカーであるCD133による分離によって得られる乳児血管腫由来幹細胞(hemangioma-derived stem cell;HemSCと略す)は脂肪,骨や神経に分化する多分化能を有することが既に証明されている。しかしHemSCがIHの増殖や退縮にどのように関わっているかは今なお不明である。われわれは,IHの増殖や退縮においてHemSCがまさに「司令塔」としての役割を果たしているとの仮説を立て,増殖期あるいは退縮期において,「どのような制御下であるいは生化学的刺激によって,HemSCが乳児血管腫の増殖や退縮に関わっているのか?」という命題を立てた.増殖期の乳児血管腫よりサンプルを採取し,Fluorescein isothiocyanate(FITC)ラベルのCD133抗体を用いたflow cytometryでは細胞を単離することができず,explant法で細胞培養を行った.Explant法では乳児血管腫よりHemSCが得られ,複数のサンプルをストックすることができた.またMTTアッセイで増殖能を確認できた。
    増殖期の乳児血管腫よりサンプルを採取し,Fluorescein isothiocyanate(FITC)ラベルのCD133抗体を用いたflow cytometryでは細胞を回収する手法を用いたが、効率が極端に悪く,単離することが困難であった.また,線維芽細胞や細菌のcontaminationも認められた.その理由としてはラベルする抗体の質的な問題や処理時の技術的問題が挙げられる.その後explant法で内皮細胞の初代培養をおこなったものの、技術的な慣れが必要で、計画より遅延した。
    代表ならびに分担研究者はこれまで脈管奇形に対するexplant法での初代培養の経験が豊富であり,方針を変更して、本法での初代培養を適用した。Explant法では乳児血管腫よりHemSCが得られ,複数のサンプルをストックすることができたことからこのまま本方法でHemSCを採取する。続いてHemSCと様々な血管内皮細胞との共培養による遊走能検討を行う予定である。細胞遊走アッセイシステムを用い、多孔性のチャンバー膜の上面に細胞浮遊液を滴下し,膜の下にはHemSCを培養した上清を添加したmediumを入れ、24、48時間の培養の後、内皮細胞を細胞数を計測する。対照群 と比較してHemSCに対する走化性を確認する。Flt-1の発現についてreal-time PCRを用いて定量的に検討することを計画している。

  7. Exploring the Significance of Skin Circadian Rhythm Formation by Light

    Grant number:18H02961  2018.4 - 2021.3

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  8. Investigation of the light signal conversion mechanism of the skin and the function

    Grant number:16K11366  2016.4 - 2019.3

    Sakakibara Shunsuke

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    The human skin, unlike other mammals, is mainly hairless and therefore the most receptive to external light in body tissues. We explored whether light signals received by human skin could be converted into intracellular signals and used. Thus far, we have shown that a photoreceptor protein called OPN4 is expressed in the skin. In this study, the light signal received via OPN4 was converted into an intracellular signal, which resulted in 1) an increase in intracellular calcium concentration and 2) a dose-dependent increase in ERK 1/2 phosphorylation, 3) forms peripheral circadian rhythm.

  9. Analysis of angiogenesis in soft tissue arteriovenous malformation

    Grant number:16K11365  2016.4 - 2019.3

    NOMURA TADASHI

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    Cultured cells were obtained from arteriovenous malformation specimens obtained from surgical specimens. RNA extracted from these cells was comprehensively examined by microarray and further immunohistochemical study showed higher expression of selectin-P (SELP) than human normal artery-derived endothelial cells and human umbilical vein-derived endothelial cells. In refluxing culture, the growth of the cultured cells did not spread in the flow direction of the culture medium, but rather grew in a reverse manner. SELP seemed to have the high possibility of being concerned in the abnormal blood vessel breeding of AVM of the body surface. It was proven that the flow had some effects on the cell proliferation, because the cell proliferated against the flow of the culture solution.

  10. Micro-anatomy atlas using quantitative protein expression analysis

    Grant number:25670750  2013.4 - 2016.3

    Hashikawa Kazunobu

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    Authorship:Principal investigator 

    Grant amount:\3770000 ( Direct Cost: \2900000 、 Indirect Cost:\870000 )

    Whole rat brain mRNA was extracted and amplified a part of the rat (Wistar rat) Hn-1 gene by the polymerase chain reaction. After performing the sequence analysis, we confirmed that this was known Hn-1 gene with homology. cRNA probe was constructed and in situ hybridization was performed for a rat brain slice after the unilateral facial nerve damage using this cRNA probe. Expression of Hn-1 mRNA was observed at facial nerve nucleus and trigeminal nerve nucleous on the damaged side.

  11. The etiology of expanding in vascular malformations -focusing on growth hormone receptor-

    Grant number:25462790  2013.4 - 2016.3

    NOMURA TADASHI

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    It was reported growth hormone receptor was overexpressed in the vessels of vascular malformations, especially in arteriovenous malformations. Tissue specimens(arteriovenous malformation(AVM), normal artery) were collected from patients undergoing resection or free flap transfer. AVM-derived vascular endothelial cell(AVMVEC) were prrimally cultured by explant method. Immunohistchemistry was used in paraffin‐embedded tissue and AVMVEC. Growth hormone receptor expression was observed in half the paraffin‐embedded AVM tissue, but in no AVMVEC. Proliferative ability of AVMVEC was as the same degree as human umbilical vein endothelial cells. In our study, growth hormone might not contribute to the expansion of arteriovenous malformation. However the proliferative ability of AVMVEC was very high, so some internal or external factor might effect the AVMVEC. Further investigation is needed.

  12. Pharmacological analysis of antispasmogenic with wire myograph

    Grant number:24659784  2012.4 - 2014.3

    SAKAKIBARA Shunsuke

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    To avoid the vascular spasm during microvascular surgery for free tissue transfer, lidocaine has been widely used. On the other hand, the proper concentration of lidocaine is unknown. We introduced wire-myograph system for pharmacological and physiological analysis of lidocaine or other substances for its anti-spasmogenic activity. We examined papaverine hydrochloride, phentolamine messmate, olprinone hydrochloride, nitroglycerine, and prostaglandin E1. On the result, those substances, except prostaglandin E1, showed concentration-dependent anti-spasmogenic activity. On the other hand, prostaglandin E1 showed concentration-dependent spasmogenic activity which may be caused by inflammatory activity. In conclusion, those substances may be used for anti-spasmogenic agent during microsurgical operation.

  13. Analysis of newly formed neural circuit after cross-link operation for facial nerve palsy -with decellularized nerve graft-

    Grant number:22591993  2010 - 2012

    HASHIKAWA Kazunobu

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    Cross-link operation is the one of the clinical operation for facial nerve palsy. We planned to administrate the acellular nerve graft for rat cross-link model and compare the three method for decellularization, hyper osmotic method, detergent method, and freeze and thaw method. In our result, hyper osmotic method isthe one of the option for cross-link nerve graft for rat model.

  14. Analysis of prostanoid receptors on lymphatic vessels

    Grant number:22591992  2010 - 2012

    NOMURA Tadashi

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    We analyzed the expression of 5 kinds of prostanoid receptors on lymphatic vessel, TP, IP, EP2, EP4, DP1, which are related to the contraction and extension of vasoactivity. All of these receptors were expressed on lymphatic vessel and patterns of expression were compatible to arteries. Our result suggest that prostanoid mayrelate to the activity of lymphatic vessels.

  15. The development of small diameter artificial vessels consisted with PVA hydrogel

    Grant number:22659322  2010 - 2011

    TAHARA Shinya

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    The small diameter(3mm) conduit consisted with PVA hydrogel was transplanted to rat abdominal artery. Immediately after the transplantation, beating was observed, however, all conduits were occulted in a few days. Next, endothelial cells were co-cultured with PVA sheet. No endothelial cells were adhered to PVA sheet. The collagen fragment was embedded into PVA hydrogel and endothelial cells were co-cultured with rotation. These cells were, then, adhered and migrated. In addition, smooth muscle cells were co-cultures, and these cells also adhered to the collagen-PVA sheet.

  16. リンパ管内皮細胞の分子生物学的解析~プロスタノイドレセプターを巡って~

    2010

    科学研究費補助金/基盤研究(C) 

    野村 正

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    Authorship:Principal investigator  Grant type:Competitive

  17. 顔面神経―舌下神経クロスリンク型神経移植術における神経回路再構築の機序を探る

    2010

    科学研究費補助金/基盤研究(C) 

    橋川 和信

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    Authorship:Principal investigator  Grant type:Competitive

  18. PVAハイドロジェルを基材とした新しい小口径人工血管の開発

    2010

    科学研究費補助金/萌芽研究 

    田原 真也

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    Grant type:Competitive

  19. Molecular biological analysis of the effect of Ag ion for wound healing

    Grant number:21592286  2009 - 2011

    SATSUKI Reiko

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    Authorship:Coinvestigator(s) 

    It has been known that silver and it's ions suppress the bacterial growth and works as an anti bacterial reagent. Recently some dressing materials and ointments contains silver ions, however, some reports indicate its toxicity for human cells and may induce the delay of wound healing. Fibroblast growth factor(bFGF) is one of the cytokine that stimulates cell migration and recombinant bFGF is used as an external medicine. The purpose of this study is to confirm if the silver ion act as cytotoxic, if the silver ion affect to the protein such as bFGF. We prepared 4 models for fibroblast culture ; model 1 : only medium with 1% CFS, model 2 : medium with bFGF and 1% CFS, model 3 : medium with bFGF, 1% CFS and silver ions, model 4 : medium with 1% CFS, bFGF which was incubated for 24 hours with silver ions, and silver ions. In this study, firstly, we confirmed that low concentration of silver ions doesn' t affect to cell growth and high concentration of silver ions does. Second, Second, bFGF mitigate the cytotoxic effect of silver ion. Third, the silver ion directly interact with bFGF and interacted bFGF became more harmful to cells.

  20. がん研究「がん外科治療における形成再建外科標準術式の確立に関する研究」

    2009

    橋川 和信

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    Authorship:Principal investigator  Grant type:Competitive

  21. 銀イオンが創傷治癒機転に及ぼす影響の分子生物学的解析-創傷治癒を促進させるか-

    2009

    科学研究費補助金/基盤研究(C) 

    皐月 玲子

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    Authorship:Principal investigator  Grant type:Competitive

  22. Development of a novel hybrid-acellular nerve graft using hypertonic sodium chloride solution

    Grant number:20390456  2008 - 2010

    TERASHI Hiroto

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    Authorship:Coinvestigator(s) 

    We developed novel decellularizing method using hypertonic sodium chloride solution. The histological evaluation for acellularization was performed by HE staining, immunostaining and electron microscope images. The acellular nerve was also transplanted to rats and evaluated histologically. The cells were washed out completely and extracellular matrix was maintained. Two months after the transplantation, Schwann cells thrust into the graft and neurofilament was running through the graft. This acellular nerve presents a useful scaffold for peripheral nerve regeneration.

  23. 脱細胞化神経をバイオスキャフォールドとする新しいハイブリッド型人工神経の開発

    2008

    科学研究費補助金/基盤研究(B) 

    寺師 浩人

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    Authorship:Principal investigator  Grant type:Competitive

  24. Neural network analysis after the "cross-link" surgery between facial nerve and hypoglossal nerve

    Grant number:19592075  2007 - 2010

    HASHIKAWA Kazunobu

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    Authorship:Principal investigator 

    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    Cross-Link nerve grafting technique between facial nerve and hypoglossal nerve with grafted sensory nerve for facial nerve palsy has demonstrated effectiveness in patients. This is very interesting surgical method, though no basic research has been performed to analyze the newly formed neural circuit. We constructed the rat cross-link nerve grafted model and introduced the neural tracer method. In our experiment, anterograde labeling showed that axons of hypoglossal neuron pass through the grafted nerve and extend to facial nerve bundle. On the other hand, in retrograde labeling study, axons from facial nucleolus extend to hypoglossal nerve bundle and from hypoglossal nucleous to facial nerve bundle. These data suggest that crossing of axons are caused by the Cross-Link nerve grafting.

  25. Elucidation of the mechanism for "Sensory Protection" on rat free muscle transfer model

    Grant number:19390453  2007 - 2008

    TAHARA Shinya

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    Authorship:Coinvestigator(s) 

  26. 脱細胞血管をスキャフォールドとした小口径人工血管モデルの作製

    Grant number:19659465  2007 - 2008

    萌芽研究

    田原 真也

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    Authorship:Coinvestigator(s) 

    本研究は、脱細胞化した同種血管をスキャホールドとして用いる小口径人工血管モデルの作製を目的としている。これまで界面活性剤法や凍結融解法により脱細胞化した小口径血管や化学合成物による小口径血管の開発が試みられてきたが、得られたマテリアルの抗原性や脆弱性、血栓形成性の壁に阻まれて実用化には至っていない。われわれは既存の方法を用いず新たな方法により血管の脱細胞化に成功した(特許申請中)。
    ラットより採取した腹部大動脈を新規の方法にて脱細胞化し、これを他の個体に顕微鏡下で腹部大動脈に吻合・移植した。1週間後および1ヵ月後に移植片を採取し、組織学的検討を行ったところ、以下の結果が得られた。(1)HE染色により、確かに脱細胞化が行われていることが確認された。(2)移植後1週目および1ヶ月目において血管の開存が認められた。(3)内皮細胞マーカーである抗vWF抗体および血管平滑筋細胞マーカーである抗α-SMA抗体による免疫染色の結果、約1週目にはvWF陽性および非陽性細胞が人工血管壁に浸潤している様子が観察された。(4)約1ヵ月後には血管内皮細胞と血管平滑筋細胞の層構築が正常血管を模して形成されていることが確認された。
    以上より、われわれが開発した新しい脱細胞化血管は物性的にも十分な強度が得られ、生物互換性も高く、有用な代替血管となることが示唆された。

  27. ラット遊離筋弁移植モデルを用いた運動・知覚神経交差再生による筋萎縮予防効果の解明

    2007

    科学研究費補助金/基盤研究(B) 

    田原 真也

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    Authorship:Principal investigator  Grant type:Competitive

  28. 脱細胞血管をスキャフォールドとした小口径人工血管モデルの作製

    2007

    科学研究費補助金/萌芽研究 

    田原 真也

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    Authorship:Principal investigator  Grant type:Competitive

  29. 顔面神経麻痺への顔面神経―舌下神経クロスリンク型神経移植術における神経科学的研究

    2007

    科学研究費補助金/基盤研究(C) 

    橋川 和信

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    Authorship:Principal investigator  Grant type:Competitive

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Industrial property rights 1

  1. 高張電解質溶液による生体組織の脱細胞化処理方法

    SAKAKIBARA SHUNSUKE, HASHIKAWA KAZUNOBU, TERASHI HIROTO, TAHARA SHINYA, 石田 泰久

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    Application no:特願2010-030777  Date applied:2010.2

    Patent/Registration no:特許5610268  Date issued:2014.9