2022/09/21 更新

写真a

サイトウ リュウタ
齋藤 竜太
SAITO Ryuta
所属
大学院医学系研究科 総合医学専攻 脳神経病態制御学 教授
大学院担当
大学院医学系研究科
学部担当
医学部 医学科
職名
教授

学位 1

  1. 博士(医学) ( 2004年3月   東北大学 ) 

研究キーワード 6

  1. 集学的治療

  2. 小児脳腫瘍

  3. 脳腫瘍治療に向けたトランスレーショナルリサーチ

  4. 脳腫瘍免疫治療の開発

  5. 脳腫瘍の外科治療

  6. 対流強化送達法(CED)の開発

研究分野 2

  1. ライフサイエンス / 脳神経外科学

  2. ライフサイエンス / 脳神経外科学  / 脳腫瘍

経歴 12

  1. 名古屋大学脳神経外科

    2020年12月 - 現在

      詳細を見る

    国名:日本国

  2. 東北大学   大学院医学系研究科   講師

    2018年 - 現在

  3. 東北大学脳神経外科

    2008年9月 - 2020年12月

      詳細を見る

    国名:日本国

  4. 東北大学   大学院医学系研究科   助教

    2008年 - 2017年

  5. さいたま赤十字病院脳神経外科

    2007年6月 - 2008年8月

      詳細を見る

    国名:日本国

  6. 仙台医療センター脳神経外科

    2007年4月 - 2007年5月

      詳細を見る

    国名:日本国

  7. 岩手県立中央病院脳神経外科

    2006年10月 - 2007年3月

      詳細を見る

    国名:日本国

  8. 広南病院脳神経外科

    2006年1月 - 2006年9月

      詳細を見る

    国名:日本国

  9. 東北大学脳神経外科

    2005年4月 - 2005年12月

      詳細を見る

    国名:日本国

  10. 宮城県立がんセンター

    2004年10月 - 2005年3月

      詳細を見る

    国名:日本国

  11. 米国カルフォルニア大学サンフランシスコ校

    2002年9月 - 2004年9月

      詳細を見る

    国名:アメリカ合衆国

  12. 東北大学脳神経外科

    1998年5月 - 2000年4月

      詳細を見る

    国名:日本国

▼全件表示

学歴 3

  1. 東北大学   神経外科学分野

    2000年4月 - 2004年3月

      詳細を見る

    国名: 日本国

  2. 東北大学   医学部   医学科

    - 1998年3月

      詳細を見る

    国名: 日本国

  3. 東北大学   医学部

    - 1998年3月

      詳細を見る

    国名: 日本国

所属学協会 23

  1. 日本脳神経外科コングレス   理事・運営委員

    2000年 - 現在

  2. 日本脳神経外科学会   理事・中部支部長

    1998年 - 現在

  3. American Society of Clinical Oncology

    2022年4月 - 現在

  4. 愛知県脳卒中対策推進委員会   委員長

    2022年4月

  5. 愛知県脳卒中協会   副会長

    2021年 - 現在

  6. 脳神経外科手術と機器学会   理事

    2000年12月 - 現在

  7. Society for Neurooncology

  8. 日本脳卒中の外科学会   評議員

  9. 日本脳卒中学会

  10. 日本小児脳神経外科学会

  11. 日本神経内視鏡学会

  12. 日本癌学会

  13. 日本がん治療学会

  14. 日本脳腫瘍病理学会

  15. 日本脳腫瘍の外科学会

  16. 日本脳腫瘍学会   理事

  17. (社)日本脳神経外科学会

  18. 日本脳腫瘍病理学会   理事、事務局長

  19. 日本脳腫瘍の外科学会

  20. 日本脳卒中学会

  21. 日本脳卒中の外科学会

  22. 日本小児脳神経外科学会

  23. 日本脳腫瘍病理学会   理事・事務局長

▼全件表示

委員歴 1

  1. 名古屋大学脳とこころの研究センター   副センター長  

    2022年4月 - 現在   

 

論文 109

  1. Dural Arteriovenous Fistula Mimicking a Brain Tumor on Methionine-positron Emission Tomography: A Case Report

    HANYU Taketo, NISHIHORI Masahiro, IZUMI Takashi, MOTOMURA Kazuya, OHKA Fumiharu, GOTO Shunsaku, ARAKI Yoshio, YOKOYAMA Kinya, UDA Kenji, SAITO Ryuta

    NMC Case Report Journal   9 巻 ( 0 ) 頁: 289 - 294   2022年12月

     詳細を見る

    記述言語:英語   出版者・発行元:The Japan Neurosurgical Society  

    <p>In this article, we report a case wherein a brain tumor was suspected based on computed tomography and magnetic resonance imaging findings. We made an initial diagnosis of malignant brain tumor based on methionine-positron emission tomography (PET) findings, but the correct diagnosis was dural arteriovenous fistula (DAVF). The patient was a 45-year-old man with DAVF who developed headache. Methionine-PET imaging showed high methionine uptake in the lesion. Although the tumor was strongly suspected from the findings of methionine-PET, the diagnosis of DAVF could be made correctly only by interpreting digital subtraction angiography and computed tomographic angiography. The findings of methionine-PET, which is considered useful in the diagnosis and denial of brain tumors, made the diagnosis of DAVF more difficult. The increased uptake of methionine-PET in DAVF is an important finding because, to our knowledge, this study is the first to report such finding. The results of this study might be useful for differential diagnoses when the diagnosis is uncertain.</p>

    DOI: 10.2176/jns-nmc.2022-0055

    CiNii Research

  2. Diagnosis and Treatment Strategies for Arachnoiditis Ossificans Following Subarachnoid Hemorrhage: A Case Report

    NAGASHIMA Yoshitaka, NISHIMURA Yusuke, ITO Hiroshi, NISHII Tomoya, OYAMA Takahiro, SAITO Ryuta

    NMC Case Report Journal   9 巻 ( 0 ) 頁: 295 - 299   2022年12月

     詳細を見る

    記述言語:英語   出版者・発行元:The Japan Neurosurgical Society  

    <p>Arachnoiditis ossificans (AO) is a rare disease, wherein ossified lesions in the subarachnoid space obstruct the flow of spinal fluid or compress the spinal cord, thereby causing myelopathy. Here we describe a rare case of AO and discuss the diagnosis and treatment strategies for this disease. A 66-year-old man with a history of subarachnoid hemorrhage presented with gait disturbance and dysuria for 7 months. Spinal magnetic resonance imaging and computed tomography (CT) myelography showed syringomyelia at the T5-T8 level and dorsally tethered spinal cord at the T8-T10 level. Preoperative noncontrast CT was not performed. The patient was diagnosed with adhesive arachnoiditis and underwent arachnoidolysis. However, intraoperative findings showed the presence of ossification lesions on the dorsal surface of the spinal cord, and intraoperative ultrasound (IOU) showed a hyperintense lesion with acoustic shadowing on the dorsal surface of the spinal cord, with limited visibility of the spinal cord. After removal of the lesions, IOU showed untethered and well-decompressed spinal cord and restoration of cerebrospinal fluid pulsation. Based on these findings, the patient was finally diagnosed with AO, which is an extremely rare disease, with an unknown frequency of occurrence. Therefore, all patients with adhesive spinal arachnoiditis require a preoperative noncontrast CT scan to evaluate for ossification lesions. In this case, we were fortunate to be able to treat AO with IOU, which demonstrated specific findings.</p>

    DOI: 10.2176/jns-nmc.2022-0036

    CiNii Research

  3. Delayed Recurrence of Choroid Plexus Carcinoma in the Sacral Spinal Cord 17 Years after Its Initial Presentation

    NAGAI Arata, KANAMORI Masayuki, SHIMODA Yoshiteru, WATANABE Mika, SAITO Ryuta, KUMABE Toshihiro, AIZAWA Toshimi, TOMINAGA Teiji

    NMC Case Report Journal   9 巻 ( 0 ) 頁: 301 - 306   2022年12月

     詳細を見る

    記述言語:英語   出版者・発行元:The Japan Neurosurgical Society  

    <p>Choroid plexus carcinomas (CPCs) are rare malignant tumors of neuro-ectodermal origin, accounting for less than 1% of all intracranial tumors. The recurrence rates of CPCs are very high and typically occur in the short-term following surgery, even after gross total removal. Here we present a rare case of CPC with spinal metastasis, which occurred long after its initial presentation. A 25-year-old woman with a history of increased intracranial pressure underwent resection for a tumor of the fourth ventricle, with a histopathological diagnosis of CPC. After tumor resection, she received 30 Gy of radiation therapy to the craniospinal axis and 20 Gy to the primary site, followed by nimustine hydrochloride chemotherapy. The residual lesion completely responded to these treatments. She suffered sensory loss in the sacral region 13 years later, followed by refractory skin ulcer in the sacral region 17 years after the initial treatments. Magnetic resonance imaging at 17 years after the initial treatments showed tumor in the sacral region, which was enlarged upon follow-up after 18 months, causing incontinence and loss of urinary intention. She underwent tumor resection, with a histological diagnosis of recurrent CPC. She received salvage re-irradiation. This case shows that CPC can spread via the cerebrospinal fluid pathways and cause spinal metastasis, with relatively slow clinical course. The present case suggests that patients with CPCs may need long-term follow-up imaging of the total neural axis to identify late recurrence at both the primary site and spinal metastasis.</p>

    DOI: 10.2176/jns-nmc.2022-0056

    CiNii Research

  4. Wearable sensor device-based detection of decreased heart rate variability in Parkinson's disease

    Suzuki Masashi, Nakamura Tomohiko, Hirayama Masaaki, Ueda Masamichi, Hatanaka Mai, Harada Yumiko, Nakatochi Masahiro, Nakatsubo Daisuke, Maesawa Satoshi, Saito Ryuta, Fujiwara Koichi, Katsuno Masahisa

    JOURNAL OF NEURAL TRANSMISSION   129 巻 ( 10 ) 頁: 1299 - 1306   2022年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:Journal of Neural Transmission  

    The evidence that heart rate variability (HRV) decreases during early Parkinson's disease (PD) largely depends on electrocardiogram data. In this study, we examined HRV in PD using wearable sensors and assessed various evaluation methods for detecting disease-related alterations. We evaluated 27 patients with PD and 23 disease controls. The wearable sensors POLAR V800 HR and POLAR H10 were used for the HRV measurements. The participants wore the two sensors for approximately 24 h, and long-term HRV data were acquired. We analyzed the standard deviation of normal R-R intervals (SDNN) and coefficient of variation of R-R intervals (CVRR) for every 100 consecutive beats. Focusing on the fluctuation of SDNN and CVRR, we extracted the minimum, first decile, first quartile, and median values of SDNN and CVRR. The area under the receiver operating characteristic curve (AUC) for each HRV parameter was calculated to differentiate PD from the disease controls. The minimum values of SDNN and CVRR had the highest AUC (SDNN: AUC 0.90, 95% confidence interval [CI] 0.78–0.96; CVRR: AUC 0.90, CI 0.76–0.96) among the evaluation methods tested. The minimum values of SDNN and CVRR were significantly decreased in PD (SDNN: 9.5 ± 4.0 ms vs. 4.4 ± 2.0 ms, p < 0.0001; CVRR: 1.15 ± 0.33% vs. 0.65 ± 0.24%, p < 0.0001). We detected decreased HRV in PD using wearable sensors. Analyzing the minimum values of the HRV parameter in long-term recordings appears to be appropriate for detecting the decrease in HRV in PD.

    DOI: 10.1007/s00702-022-02528-y

    Web of Science

    Scopus

    PubMed

  5. Endoscopic Trans-Mini-Cylinder Biopsy for Intraparenchymal Brain Lesions.

    Takeuchi K, Ohka F, Nagata Y, Maeda S, Tanahashi K, Araki Y, Yamamoto T, Sasaki H, Mizuno A, Harada H, Saito R

    World neurosurgery     2022年9月

     詳細を見る

    記述言語:英語  

    DOI: 10.1016/j.wneu.2022.08.147

    PubMed

  6. Magnetic resonance imaging scans of cervical spinal cord ependymoma with changing radiological features over a short period of time.

    Nagashima Y, Nishimura Y, Saito R

    World neurosurgery     2022年8月

     詳細を見る

    記述言語:英語  

    DOI: 10.1016/j.wneu.2022.08.116

    PubMed

  7. Human herpesvirus 6 DNA was not detected in a brain specimen from a patient with mesial temporal sclerosis after status epilepticus due to human herpesvirus 6 infection

    Kawamura Yoshiki, Maesawa Satoshi, Numoto Shingo, Saito Ryuta, Yoshikawa Tetsushi, Okumura Akihisa

    EPILEPSIA OPEN     2022年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:Epilepsia Open  

    We performed virological analysis of resected brain tissues from a patient with temporal lobe epilepsy associated with mesial temporal sclerosis after febrile status epilepticus caused by human herpesvirus 6 infection. The patient had febrile status epilepticus at 9 months of age associated with human herpesvirus 6 infection. Magnetic resonance imaging revealed reduced water diffusion in the right temporal lobe and hippocampus. Polymerase chain reaction analysis detected 1.6 × 105 copies/μg of human herpesvirus 6 DNA in whole blood, but none in the cerebrospinal fluid. The patient developed temporal lobe epilepsy associated with mesial temporal sclerosis at 67 months of age, necessitating surgical treatment. Anterior temporal lobectomy was performed at 171 months of age. Real-time polymerase chain reaction analysis of resected brain tissues revealed no viral DNA. In our patient, human herpesvirus 6 infection triggered febrile status epilepticus, while direct evidence to prove contribution of HHV-6 to the development of MTS was not obtained.

    DOI: 10.1002/epi4.12634

    Web of Science

    Scopus

    PubMed

  8. 経鼻頭蓋底術後髄液漏の検討

    竹内 和人, 永田 雄一, 佐々木 博勇, 水野 晃宏, 齋藤 竜太

    日本内分泌学会雑誌   98 巻 ( S.HPT ) 頁: 25 - 27   2022年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:一般社団法人 日本内分泌学会  

    DOI: 10.1507/endocrine.98.s.hpt_25

    CiNii Research

  9. ラトケ嚢胞に類似した所見を示した頭蓋咽頭腫の一例

    原田 英幸, 竹内 和人, 永田 雄一, 棚橋 邦明, 佐々木 博勇, 水野 晃宏, 井下 尚子, 齋藤 竜太

    日本内分泌学会雑誌   98 巻 ( S.HPT ) 頁: 72 - 73   2022年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:一般社団法人 日本内分泌学会  

    DOI: 10.1507/endocrine.98.s.hpt_72

    CiNii Research

  10. Primary central nervous system malignant lymphoma in a patient with rheumatoid arthritis receiving tocilizumab: illustrative case.

    Ohno M, Kuramitsu S, Iwakoshi A, Yamaguchi J, Ohka F, Saito R

    Journal of neurosurgery. Case lessons   4 巻 ( 6 )   2022年8月

     詳細を見る

    記述言語:英語  

    DOI: 10.3171/CASE22256

    PubMed

  11. Antiplatelet therapy discontinuation after stent-assisted coil embolization for intracranial aneurysms: a single-center, long-term, retrospective, observational study.

    Goto S, Izumi T, Nishihori M, Imai T, Araki Y, Kanamori F, Uda K, Yokoyama K, Saito R

    Journal of neurosurgery     頁: 1 - 8   2022年8月

     詳細を見る

    記述言語:英語  

    DOI: 10.3171/2022.6.JNS22815

    PubMed

  12. Radiological Analysis of Minimally Invasive Microscopic Laminectomy for Lumbar Canal Stenosis with a Focus on Multilevel Stenosis and Spondylolisthesis.

    Awaya T, Nishimura Y, Eguchi K, Nagashima Y, Ando R, Akahori S, Yoshikawa S, Haimoto S, Hara M, Takayasu M, Saito R

    World neurosurgery   164 巻   頁: e224 - e234   2022年8月

     詳細を見る

    記述言語:英語   出版者・発行元:World Neurosurgery  

    Objective: We retrospectively compared the radiological and clinical outcomes of two different surgical techniques (lumbar spinous process splitting laminectomy [LSPSL] and unilateral laminotomy for bilateral decompression [ULBD]) to treat lumbar spinal canal stenosis (LCS). Methods: We performed a retrospective comparative study of 141 consecutive patients with an average age of 70.8 ± 9.4 years who had undergone LSPSL or ULBD for LCS between April 2015 and April 2019. None of the patients had developed remote fractures of the spinous processes using either technique. These cases were divided into 2 groups: group L, 73 patients who had undergone LSPSL from April 2015 to April 2017; and group U, 68 patients who had undergone ULBD from May 2017 to April 2019. The clinical and radiological outcomes and surgical complications at the 1-year postoperative follow-up period were evaluated. Results: We found no significant differences in the operative time between the 2 groups. However, group U had had significantly less blood loss than group L. The facet joints were significantly well preserved in group U. We examined the multilevel and spondylolisthesis cases separately and found that both surgical procedures were equally effective and that the visual analog scale scores for back or leg pain and Japanese Orthopaedic Association scores had significantly improved postoperatively in each group. Group U showed better outcomes in terms of LCS recurrence, with 3 patients in the group L requiring repeat surgery. Conclusions: We found both ULBD and LSPSL to be safe and effective techniques for LCS, even for patients with spondylolisthesis and multilevel disease. ULBD was superior in terms of recurrence prevention, preservation of the facet joints, and less blood loss.

    DOI: 10.1016/j.wneu.2022.04.079

    Scopus

    PubMed

  13. Role of the parietooccipital fissure and its implications in the pathophysiology of posterior medial temporal gliomas 国際誌

    Shibahara Ichiyo, Saito Ryuta, Kanamori Masayuki, Sonoda Yukihiko, Sato Sumito, Hide Takuichiro, Tominaga Teiji, Kumabe Toshihiro

    JOURNAL OF NEUROSURGERY   137 巻 ( 2 ) 頁: 505 - 514   2022年8月

     詳細を見る

    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Neurosurgery  

    OBJECTIVE The parietooccipital fissure is an anatomical landmark that divides the temporal, occipital, and parietal lobes. More than 40% of gliomas are located in these three lobes, and the temporal lobe is the most common location. The parietooccipital fissure is located just posterior to the medial temporal lobe, but little is known about the clinical significance of this fissure in gliomas. The authors investigated the anatomical correlations between the parietooccipital fissure and posterior medial temporal gliomas to reveal the radiological features and unique invasion patterns of these gliomas. METHODS The authors retrospectively reviewed records of all posterior medial temporal glioma patients treated at their institutions and examined the parietooccipital fissure. To clarify how the surrounding structures were invaded in each case, the authors categorized tumor invasion as being toward the parietal lobe, occipital lobe, isthmus of the cingulate gyrus, insula/basal ganglia, or splenium of the corpus callosum. DSI Studio was used to visualize the fiber tractography running through the posterior medial temporal lobe. RESULTS Twenty-four patients with posterior medial temporal gliomas were identified. All patients presented with a parietooccipital fissure as an uninterrupted straight sulcus and as the posterior border of the tumor. Invasion direction was toward the parietal lobe in 13 patients, the occipital lobe in 4 patients, the isthmus of the cingulate gyrus in 19 patients, the insula/basal ganglia in 3 patients, and the splenium of the corpus callosum in 8 patients. Although the isthmus of the cingulate gyrus and the occipital lobe are located just posterior to the posterior medial temporal lobe, there was a significantly greater preponderance of invasion toward the isthmus of the cingulate gyrus than toward the occipital lobe (p = 0.00030, McNemar test). Based on Schramm's classification for the medial temporal tumors, 4 patients had type A and 20 patients had type D tumors. The parietooccipital fissure determined the posterior border of the tumors, resulting in a unique and identical radiological feature. Diffusion spectrum imaging (DSI) tractography indicated that the fibers running through the posterior medial temporal lobe toward the occipital lobe had to detour laterally around the bottom of the parietooccipital fissure. CONCLUSIONS Posterior medial temporal gliomas present identical invasion patterns, resulting in unique radiological features that are strongly affected by the parietooccipital fissure. The parietooccipital fissure is a key anatomical landmark for understanding the complex infiltrating architecture of posterior medial temporal gliomas.

    DOI: 10.3171/2021.7.JNS21990

    Web of Science

    Scopus

    PubMed

  14. Long noncoding RNA profile of the intracranial artery in patients with moyamoya disease.

    Mamiya T, Kanamori F, Yokoyama K, Ota A, Karnan S, Uda K, Araki Y, Maesawa S, Yoshikawa K, Saito R

    Journal of neurosurgery     頁: 1 - 8   2022年7月

     詳細を見る

    記述言語:英語  

    DOI: 10.3171/2022.5.JNS22579

    PubMed

  15. Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor.

    Kato S, Maesawa S, Bagarinao E, Nakatsubo D, Tsugawa T, Mizuno S, Kawabata K, Tsuboi T, Suzuki M, Shibata M, Takai S, Ishizaki T, Torii J, Mutoh M, Saito R, Wakabayashi T, Katsuno M, Ozaki N, Watanabe H, Sobue G

    Journal of neurosurgery     頁: 1 - 12   2022年7月

     詳細を見る

    記述言語:英語  

    DOI: 10.3171/2022.5.JNS22411

    PubMed

  16. The usefulness and safety of dexmedetomidine for postoperative sedation in pediatric patients with moyamoya disease.

    Kanamori F, Araki Y, Yokoyama K, Uda K, Kurimoto M, Shiba Y, Mamiya T, Takayanagi K, Ishii K, Nishihori M, Izumi T, Okamoto S, Saito R

    Journal of neurosurgery. Pediatrics     頁: 1 - 7   2022年7月

     詳細を見る

    記述言語:英語  

    DOI: 10.3171/2022.6.PEDS2241

    PubMed

  17. Medical Management of a Mural Thrombus Inducing Repeated Ischemic Strokes in a Patient with Congenital Afibrinogenemia

    Nishihori Masahiro, Araki Yoshio, Suzuki Nobuaki, Tamura Shogo, Hattori Mayo, Izumi Takashi, Goto Shunsaku, Yokoyama Kinya, Uda Kenji, Matsushita Tadashi, Saito Ryuta

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES   31 巻 ( 7 ) 頁: 106526   2022年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:Journal of Stroke and Cerebrovascular Diseases  

    Objectives: Congenital afibrinogenemia is an autosomal recessive inherited disorder that can cause thrombotic as well as hemorrhagic events. We describe a case of repeated mild ischemic strokes due to a mural thrombus in the carotid artery and our medical treatment. Case description: A 49-year-old woman with congenital afibrinogenemia developed two minor ischemic strokes in two months. Clinical images revealed scattered fresh infarcts in the right middle cerebral artery region and mild cervical carotid artery stenosis. The risk for surgical treatment was considered to be extraordinarily high. The patient was treated with 100 mg/day of aspirin and 3 g fibrinogen infusion every two weeks. After the one-year course of medication, the mural thrombus gradually decreased, and there were no bleeding or ischemic stroke events. Conclusion: This case report highlights the successful treatment of an ischemic stroke in a patient with a congenital afibrinogenemia with an antiplatelet agent and fibrinogen replacement. There are no guidelines for managing ischemic stroke in patients with congenital afibrinogenemia, and further studies are needed.

    DOI: 10.1016/j.jstrokecerebrovasdis.2022.106526

    Web of Science

    Scopus

    PubMed

  18. 特集 癒着性くも膜炎の病態と治療法を学ぼう 術後に生じる癒着性くも膜炎

    西村 由介, 永島 吉孝, 齋藤 竜太

    脊椎脊髄ジャーナル   35 巻 ( 2 ) 頁: 99 - 105   2022年6月

     詳細を見る

    出版者・発行元:三輪書店  

    DOI: 10.11477/mf.5002201799

    CiNii Research

  19. Efficacy and safety of the endoscopic "wet-field" technique for removal of supratentorial cavernous malformations

    Takeuchi Kazuhito, Nagata Yuichi, Tanahashi Kuniaki, Araki Yoshio, Mizuno Akihiro, Sasaki Hiroo, Harada Hideyuki, Ito Keishi, Saito Ryuta

    ACTA NEUROCHIRURGICA     2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:Acta Neurochirurgica  

    Objective: Cerebral cavernous malformations (CMs) presenting with focal neurological symptoms or mass effects require surgical removal. In recent years, cylindrical retractors have been widely utilized for the removal of deep-seated lesions during both microscopic and endoscopic surgery. In the present study, we evaluated the efficacy and safety of endoscopic transcylinder removal of CMs using a novel wet-field technique. Methods: We included 13 patients with supratentorial CMs who had undergone endoscopic transcylinder surgery between April 2013 and March 2022. One patient experienced recurrence of the CM and underwent a second endoscopic transcylinder surgery. Therefore, we retrospectively evaluated 14 procedures. The surgical field was continuously irrigated with artificial cerebrospinal fluid to maintain expansion and visualization of the tumor bed. We termed this method as the “wet-field technique.” Patient characteristics, symptoms, and pre- and postoperative magnetic resonance imaging results were obtained from medical records. Results: The average maximum CM diameter was 35.3 mm (range: 10–65 mm). Cylinder diameters were 6 mm in eight procedures, 10 mm in four procedures, and 17 mm in one procedure. Wet-field technique was applied in all cases. The endoscope provided a bright field of view even under water. Continuous water irrigation made it easier to observe the entire tumor bed which naturally expanded by water pressure. Gross total resection was achieved in 13 procedures, while subtotal resection was achieved in one procedure. No surgical complications were observed. Conclusions: The endoscopic transcylinder removal using wet-field technique is safe and effective for the removal of symptomatic intracranial supratentorial CMs.

    DOI: 10.1007/s00701-022-05273-z

    Web of Science

    Scopus

    PubMed

  20. The first-in-human phase I study of a brain-penetrant mutant IDH1 inhibitor DS-1001 in patients with recurrent or progressive IDH1-mutant gliomas

    Natsume Atsushi, Arakawa Yoshiki, Narita Yoshitaka, Sugiyama Kazuhiko, Hata Nobuhiro, Muragaki Yoshihiro, Shinojima Naoki, Kumabe Toshihiro, Saito Ryuta, Motomura Kazuya, Mineharu Yohei, Miyakita Yasuji, Yamasaki Fumiyuki, Matsushita Yuko, Ichimura Koichi, Ito Kazumi, Tachibana Masaya, Kakurai Yasuyuki, Okamoto Naoko, Asahi Takashi, Nishijima Soichiro, Yamaguchi Tomoyuki, Tsubouchi Hiroshi, Nakamura Hideo, Nishikawa Ryo

    NEURO-ONCOLOGY     2022年6月

     詳細を見る

    記述言語:日本語  

    DOI: 10.1093/neuonc/noac155

    Web of Science

    PubMed

  21. Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review

    Kibe Yuji, Tanahashi Kuniaki, Ohtakara Kazuhiro, Okumura Yuka, Ohka Fumiharu, Takeuchi Kazuhito, Nagata Yuichi, Motomura Kazuya, Akahori Sho, Mizuno Akihiro, Sasaki Hiroo, Shimizu Hiroyuki, Yamaguchi Junya, Nishikawa Tomohide, Yokota Kenji, Saito Ryuta

    BMC NEUROLOGY   22 巻 ( 1 ) 頁: 223   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:BMC Neurology  

    Background: Eccrine spiradenocarcinoma (SC), also known as malignant eccrine spiradenoma, is a rare malignant cutaneous adnexal neoplasm arising from long-standing benign eccrine spiradenoma. Malignant skin tumors rarely show direct intracranial invasion. However, once the intracranial structure is infiltrated, curative excision with sufficient margins can become extremely difficult, particularly when the venous sinuses are involved. No effective adjuvant therapies have yet been established. Here, we report an extremely rare case of scalp eccrine SC with direct intracranial invasion, which does not appear to have been reported previously. Case presentation: An 81-year-old woman presented with a large swelling on the parietal scalp 12 years after resection of spiradenoma from the same site. The tumor showed intracranial invasion with involvement of the superior sagittal sinus and repeated recurrences after four surgeries with preservation of the sinus. The histopathological diagnosis was eccrine SC. Adjuvant high-precision external beam radiotherapy (EBRT) proved effective after the third surgery, achieving remission of the residual tumor. The patient died 7 years after the first surgery for SC. Conclusions: Scalp SC with direct intracranial invasion is extremely rare. Radical resection with tumor-free margins is the mainstay of treatment, but the involvement of venous sinuses makes this unfeasible. High-precision EBRT in combination with maximal resection preserving the venous sinuses could be a treatment option for local tumor control.

    DOI: 10.1186/s12883-022-02749-4

    Web of Science

    Scopus

    PubMed

  22. The prognosis and treatment effectiveness of de novo aneurysm formation after radiation therapy for brain tumor

    Shinoda Satoshi, Muraoka Shinsuke, Shimizu Hiroyuki, Koketsu Naoki, Araki Yoshio, Saito Ryuta

    NEUROSURGICAL REVIEW     2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurosurgical Review  

    Radiation therapy is a well-established, minimally invasive method of treating brain tumors. In recent years, the number of post-radiotherapy patients has increased, and delayed side effects are evident. De novo aneurysm formation after radiation often manifests as fatal subarachnoid hemorrhage (SAH), resulting in severe clinical outcomes. Nevertheless, the prognosis and therapeutic efficacy of radiation-induced aneurysms (RIAs) remain unclear. Using the PubMed database from 1980 to 2021, we screened 45 articles (53 individual cases) on RIAs; approximately 70% of RIAs were diagnosed after rupture. Of 38 ruptured RIAs, 12 (31.6%) had modified Rankin scale (mRS) 5–6. On the other hand, all unruptured RIAs (15 cases) recovered without neurological deficits (p = 0.012). Ten of the 39 ruptured RIAs were treated surgically, and 22 were treated endovascularly. There was no significant difference in mRS between treatment modalities (p = 0.393), but conservative therapy was significantly related to unfavorable outcomes (p = 0.025). To improve clinical outcomes, RIAs need to be diagnosed before rupture. Surgeons should be aware of de novo aneurysm formation in patients long after radiation therapy.

    DOI: 10.1007/s10143-022-01820-5

    Web of Science

    Scopus

    PubMed

  23. Changes in cerebral blood flow in the postoperative chronic phase after combined cerebral revascularization for moyamoya disease with ischaemic onset

    Araki Yoshio, Mamiya Takashi, Fujita Naotoshi, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Takayanagi Kai, Ishii Kazuki, Nishihori Masahiro, Takeuch Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Tanei Takafumi, Sumitomo Masaki, Okamoto Sho, Izumi Takashi, Kato Katsuhiko, Saito Ryuta

    NEUROSURGICAL REVIEW   45 巻 ( 3 ) 頁: 2471 - 2480   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurosurgical Review  

    The purpose of this study was to examine the effects of combined revascularization for ischaemic-onset moyamoya disease (MMD) on cerebral haemodynamics by comparing cerebral blood flow (CBF) during the postoperative chronic phase with preoperative CBF. A retrospective cohort of 24 MMD patients (representing 31 surgeries) who received single photon emission computed tomography (SPECT) before and more than 6 months after surgery was investigated. The CBF value of each vascular territory was extracted from SPECT data, and the value relative to the ipsilateral cerebellar value (relative CBF, or RCBF) was calculated. The correlation between the revascularization effect and the proportional change in RCBF before and after surgery (calculated as post-RCBF/pre-RCBF (“post/pre-RCBF”)) was analysed. Furthermore, the relationships between changes in neurological symptoms and post/pre-RCBF were investigated. Preoperative and postoperative mean RCBF values were 0.92 ± 0.15 and 0.96 ± 0.13 (p = 0.619) in the anterior cerebral artery territory, 0.99 ± 0.17 and 1.01 ± 0.17 (p = 0.598) in the middle cerebral artery territory and 1.15 ± 0.22 and 1.14 ± 0.19 (p = 0.062) in the posterior cerebral artery territory, respectively. No significant correlation was found between the revascularization score and post/pre-RCBF. The revascularization score and post/pre-RCBF were not significant predictors of worsening neurological symptoms postoperatively. No significant change in RCBF was observed in any vascular territory in the chronic phase after revascularization. Combined revascularization may assist in the redirection of blood flow from the internal to the external carotid system and contribute to CBF maintenance.

    DOI: 10.1007/s10143-022-01774-8

    Web of Science

    Scopus

    PubMed

  24. Quick and simple dural threading technique for transsphenoidal surgery - dural tenting, haemostasis and skull base reconstruction

    Takeuchi Kazuhito, Nagata Yuichi, Tanahashi Kuniaki, Saito Ryuta

    ACTA NEUROCHIRURGICA   164 巻 ( 6 ) 頁: 1619 - 1622   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:Acta Neurochirurgica  

    Background: Dural suturing is one of the most robust reconstruction methods in transsphenoidal surgery; however, the technique is considered difficult, primarily due to the restricted range of needle movement. Method: We performed dural threading during transsphenoidal surgery by holding the needle with forceps as a hook and moving the needle in a distal to proximal direction. Conclusion: Our dural suturing technique is simple and quick. It can be used not only for dural closure but also for other procedures, such as controlling haemostasis from the intercavernous sinus and dural tenting.

    DOI: 10.1007/s00701-022-05227-5

    Web of Science

    Scopus

    PubMed

  25. Evaluation of the differences in pressure applied to the vessel wall by different types of balloon remodeling microcatheters in an experimental model

    Ikezawa Mizuka, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Tamari Yosuke, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Goto Shunsaku, Kropp Asuka E., Otsuka Takafumi, Kato Naoki, Nakano Mizuki, Saito Ryuta

    INTERVENTIONAL NEURORADIOLOGY   28 巻 ( 3 ) 頁: 323 - 331   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:Interventional Neuroradiology  

    Background: We examined compliance differences among balloon remodeling microcatheters, which have not been established previously. Methods: Straight and 120° angulated vascular models were created in a 3 mm diameter tube with 3 mm hole (vascular model A), a tube with a 4 mm hole (vascular model B), and a 4 mm diameter tube (vascular model C). We compared the pressure exerted when each balloon was herniated 1 or 2 mm between three compliant balloons (SHOURYU SR, TransForm C, and Scepter C) and four super-compliant balloons (HyperForm, SHOURYU HR, TransForm SC, and Scepter XC). Results: In vascular model A, there was a significant difference in the pressure exerted by compliant balloons and super-compliant balloons in both the straight and angulated models. In the straight model (1 and 2 mm), the lowest pressure was exerted by HyperForm (super-compliant balloons group) and SHOURYU SR (compliant balloons group). The lowest pressure was exerted in the angulated model by HyperForm (super-compliant balloons group) and Scepter C (compliant balloons group). The Scepter balloon exerted higher pressure in the straight model than other balloon remodeling microcatheters but less in the angulated model. In vascular model B, the pressure decreased in all balloons compared with model A. In vascular model C, the pressure increased in all balloons compared with model A. Conclusions: Pressure differed across balloon remodeling microcatheters. In addition, vessel shape and diameter, and hole size, affected the results. Our findings can help select balloon remodeling microcatheters.

    DOI: 10.1177/15910199211031765

    Web of Science

    Scopus

    PubMed

  26. Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors

    Nagashima Yoshitaka, Nishimura Yusuke, Eguchi Kaoru, Yamaguchi Junya, Haimoto Shoichi, Ohka Fumiharu, Takayasu Masakazu, Saito Ryuta

    NEUROSPINE   19 巻 ( 2 ) 頁: 262 - 271   2022年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurospine  

    The study of genetic alterations and molecular biology in central nervous system (CNS) tumors has improved the accuracy of estimations of patient prognosis and tumor categorization. Therefore, the updated 2021 World Health Organization (WHO) classification includes various diagnostic genes, molecules, and pathways for diagnosis, as well as histological findings. These findings are expected both to have diagnostic applications and to facilitate new targeted therapies that target tumor-specific genetic changes and molecular biology. Intramedullary spinal cord tumors (IMSCTs) are rare CNS tumors that are difficult to treat because they occur in eloquent areas. Although the genetic underpinnings of IMSCTs remain unclear compared to their intracranial counterparts, the genetic characteristics of these tumors are gradually being revealed. Here, we describe the major changes in the new 2021 WHO classification and review the major types of IMSCTs, with an emphasis on their clinical features and genetic alterations.

    DOI: 10.14245/ns.2244168.084

    Web of Science

    Scopus

    PubMed

  27. Supratotal Resection of Gliomas With Awake Brain Mapping: Maximal Tumor Resection Preserving Motor, Language, and Neurocognitive Functions

    Motomura Kazuya, Ohka Fumiharu, Aoki Kosuke, Saito Ryuta

    FRONTIERS IN NEUROLOGY   13 巻   頁: 874826   2022年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:Frontiers in Neurology  

    Gliomas are a category of infiltrating glial neoplasms that are often located within or near the eloquent areas involved in motor, language, and neurocognitive functions. Surgical resection being the first-line treatment for gliomas, plays a crucial role in patient outcome. The role of the extent of resection (EOR) was evaluated, and we reported significant correlations between a higher EOR and better clinical prognosis of gliomas. However, recurrence is inevitable, even after aggressive tumor removal. Thus, efforts have been made to achieve extended tumor resection beyond contrast-enhanced mass lesions in magnetic resonance imaging (MRI)-defined areas, a process known as supratotal resection. Since it has been reported that tumor cells invade beyond regions visible as abnormal areas on MRI, imaging underestimates the true spatial extent of tumors. Furthermore, tumor cells have the potential to spread 10–20 mm away from the MRI-verified tumor boundary. The primary goal of supratotal resection is to maximize EOR and prolong the progression-free and overall survival of patients with gliomas. The available data, as well as our own work, clearly show that supratotal resection of gliomas is a feasible technique that has improved with the aid of awake functional mapping using intraoperative direct electrical stimulation. Awake brain mapping has enabled neurosurgeons achieve supratotal resection with favorable motor, language, and neurocognitive outcomes, ensuring a better quality of life in patients with gliomas.

    DOI: 10.3389/fneur.2022.874826

    Web of Science

    Scopus

    PubMed

  28. Cutoff values for the best management strategy for magnetic resonance-guided focused ultrasound ablation for essential tremor.

    Torii J, Maesawa S, Nakatsubo D, Tsugawa T, Kato S, Ishizaki T, Takai S, Shibata M, Wakabayashi T, Tsuboi T, Suzuki M, Saito R

    Journal of neurosurgery     頁: 1 - 12   2022年5月

     詳細を見る

    記述言語:英語  

    DOI: 10.3171/2022.3.JNS212460

    PubMed

  29. Blood flow stagnation after treatment of a giant internal carotid artery aneurysm: a computed fluid dynamics analysis

    Muraoka Shinsuke, Takagi Reiya, Araki Yoshio, Uda Kenji, Sumitomo Masaki, Okamoto Sho, Nishihori Masahiro, Izumi Takashi, Nakamura Masanori, Saito Ryuta

    SCIENTIFIC REPORTS   12 巻 ( 1 ) 頁: 7283   2022年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:Scientific Reports  

    Balloon test occlusion (BTO) is an angiographic test to evaluate ischemic tolerance after permanent occlusion of an internal carotid artery (ICA). BTO can simulate ischemia caused by parent artery occlusion and can be used to select a suitable bypass surgery using specific criteria. On the other hand, a postoperative thrombus can form despite proper case selection, optimal radiological evaluation, and an appropriate surgical strategy. Postoperative ischemic complications related to perforating branches are clinically significant. This simulation study aimed to analyze postoperative flow characteristics and elucidate the cause of ischemic complications related to the perforating branch using computational fluid dynamics (CFD). An unexpected postoperative thrombus formation related to the perforating branch occurred after treating a giant aneurysm in the cavernous portion of the ICA in a patient. Three-dimensional digital subtraction angiography was used to acquire flow data and set up the CFD simulation. The flow simulations were performed at various bypass flow rates. The CFD analysis indicated flow stagnation in the ICA only when surgical treatment using a low-flow bypass graft was performed. Thrombus formation may lead to ischemic complications related to the perforating branch, such as the anterior choroidal artery. BTO did not reflect the influence of bypass blood flow. Therefore, recognizing that blood flow stagnation may occur and comprehensively deciding on the surgical strategy by CFD analysis can be helpful to prevent ischemic complications in patients with giant aneurysms.

    DOI: 10.1038/s41598-022-11321-6

    Web of Science

    Scopus

    PubMed

  30. A novel endoscopic ventriculocisternostomy and stenting technique with a transparent acryl puncture needle for a trapped temporal horn: a technical report and literature review

    Yamamoto Taiki, Takeuchi Kazuhito, Nagata Yuichi, Mizuno Akihiro, Harada Hideyuki, Saito Ryuta

    NEUROSURGICAL REVIEW   45 巻 ( 2 ) 頁: 1783 - 1789   2022年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurosurgical Review  

    Trapped temporal horn is a rare type of noncommunicating focal hydrocephalus, and no standard treatment has been established yet for trapped temporal horn. Recent studies have shown the efficacy of endoscopic ventriculocisternostomy by opening the choroidal fissure; however, some surgical complications were reported during the procedure. Thus, we aimed to report a novel endoscopic ventriculocisternostomy and stenting technique for trapped temporal horn. In this technique, a 5.8-mm transparent acryl puncture needle with a 2.7-mm 0° rigid endoscope was used to open the choroidal fissure. It can fenestrate the choroidal fissure under real-time endoscopic observation of the critical neurovascular structures over the choroidal fissure. Moreover, the dull tip of the needle is less likely to injure the critical neurovascular structures, resulting in safer ventriculocisternostomy than the previously reported technique. Then, a stent is placed along the tract to prevent future obstruction of the stoma. Six trapped temporal horns in four patients were treated using the technique. All the patients showed improved symptoms with no surgical complications. None of the patients showed recurrence of trapped temporal horn during the mean follow-up period of 39.3 months. The combination of endoscopic ventriculocisternostomy and stenting with a transparent acryl puncture needle is a safe and effective treatment option for trapped temporal horn.

    DOI: 10.1007/s10143-021-01634-x

    Web of Science

    Scopus

    PubMed

  31. Risk Factors for Cerebral Infarction Early After Revascularization in Children Younger than 5 Years with Moyamoya Disease

    Araki Yoshio, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Nishihori Masahiro, Takeuchi Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Okamoto Sho, Sumitomo Masaki, Izumi Takashi, Saito Ryuta

    WORLD NEUROSURGERY   160 巻   頁: E220 - E226   2022年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:World Neurosurgery  

    Objective: Cerebral revascularization is necessary for pediatric patients younger than 5 years with moyamoya disease (MMD). However, they have a high risk of developing cerebral infarction early after surgery. This study aimed to analyze the risk factors for developing cerebral infarction among these patients. Methods: The charts of 21 consecutive patients with MMD (39 surgeries) younger than 5 years who had undergone revascularization at our hospital were retrospectively analyzed. Because cerebral infarction occurring within 1 month after surgery was the primary end point, other clinical information was evaluated, including each surgical procedure. Multivariate analysis of the risk factors for postoperative cerebral infarction was performed. Results: Cerebral infarction occurred after 7 of 39 surgeries (17.9%). Of the 39 surgeries, 23 (59%) included direct and indirect combined revascularization. The incidence of cerebral infarction did not differ significantly between the combined (21.7%) and indirect (12.5%) groups (P = 0.46). Logistic regression showed no association between the revascularization procedure and the occurrence of cerebral infarction after surgery (P = 0.3). However, younger age at surgery was correlated with a higher risk of developing cerebral infarction in the early postoperative period (P = 0.05). Conclusions: No differences were found in the risk of developing cerebral infarction early after surgery as a result of surgical procedures. However, younger patients had higher postoperative risk. Further multicenter research should examine this issue for young pediatric patients with moyamoya at high risk of developing cerebral infarction.

    DOI: 10.1016/j.wneu.2021.12.115

    Web of Science

    Scopus

    PubMed

  32. Modified Shoelace Dural Closure with Collagen Matrix in Extended Transsphenoidal

    Nagata Yuichi, Takeuchi Kazuhito, Sasaki Hiroo, Mizuno Akihiro, Harada Hideyuki, Tanahashi Kuniaki, Araki Yoshio, Saito Ryuta

    NEUROLOGIA MEDICO-CHIRURGICA   62 巻 ( 4 ) 頁: 203 - 208   2022年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurologia Medico-Chirurgica  

    Extended endonasal transsphenoidal surgery (eTSS) offers a wide surgical field for various parasellar lesions; however, intraoperative high-flow cerebrospinal fluid (CSF) leakage is inevitable. Therefore, se-cure sellar reconstruction methods are essential to prevent postoperative CSF leakage. Although collagen matrix has been applied for dural reconstruction in neurosurgery, its suitability for application in extended eTSS remains unclear. Eighteen patients underwent modified shoelace dural closure using collagen matrix after lesionectomy via extended eTSS. In this technique, a collagen matrix, which was placed subdurally (inlay graft), was continuously sutured with both open dural edges like a shoelace. Then, another collagen matrix was placed epidurally (onlay graft), and rigid reconstruction was performed using the septal bone and a resorbable fixation mesh. Postoperative CSF leakage did not occur in 17 patients but did occur in 1 patient with tuberculum sellae meningioma. In this case, the CSF leakage point was detected just around the area between the coagulated dura and the adjacent colla-gen matrix. The collagen matrix harvested from this area was pathologically examined; neovasculari-zation and fibroblastic infiltration into the collagen matrix were not detected. On the other hand, ne-ovascularization and fibroblast infiltration into the collagen matrix were apparent on the surface of the collagen matrix harvested from the non-CSF leakage area. Our novel dural closure technique using collagen matrix could be an effective option for sellar reconstruction in extended eTSS; however, it should be applied in patients in whom normal dural edges are preserved.

    DOI: 10.2176/jns-nmc.2021-0355

    Web of Science

    Scopus

    PubMed

    CiNii Research

  33. Challenging direct bypass surgery for very young children with moyamoya disease: technical notes

    Araki Yoshio, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Nishihori Masahiro, Takeuchi Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Okamoto Sho, Sumitomo Masaki, Izumi Takashi, Saito Ryuta

    NEUROSURGICAL REVIEW   45 巻 ( 2 ) 頁: 1799 - 1807   2022年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurosurgical Review  

    Cerebral revascularization for moyamoya disease (MMD) is an effective treatment for improving cerebral ischaemia and preventing rebleeding. Although direct bypass surgery is commonly performed on older children and adults, it is challenging in very young children due to the high difficulty level of the procedure. The subjects were MMD patients under 3 years of age on whom surgery was performed by a single surgeon (Y.A.). Preoperative clinical findings, information related to direct bypass surgery, bypass patency, and the incidence of postoperative stroke were investigated. Combined revascularization, including direct bypass surgery, was performed on 3 MMD patients (3 sides) under 3 years of age. The average diameter of the grafts used in direct bypass was 0.8 mm. The average recipient diameter was 0.8 ± 0.17 (range 0.6–1) mm. In all cases, the anastomotic procedure was completed using 11–0 monofilament nylon thread, and patency was confirmed. Direct bypass for MMD patients under 3 years old is technically challenging. However, despite the anatomical differences between very young children and elderly individuals, direct bypass surgery could certainly be completed. In addition, a rapid recovery from cerebral blood flow insufficiency could yield a promising neurological outcome.

    DOI: 10.1007/s10143-021-01685-0

    Web of Science

    Scopus

    PubMed

  34. Advantages of petrosectomy for superficial temporal artery to superior cerebellar artery bypass based on three-dimensional distance measurements using cadaver heads

    Uda Kenji, Tanahashi Kuniaki, Mamiya Takashi, Kanamori Fumiaki, Yokoyama Kinya, Nishihori Masahiro, Izumi Takashi, Araki Yoshio, Saito Ryuta

    NEUROSURGICAL REVIEW   45 巻 ( 2 ) 頁: 1617 - 1624   2022年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurosurgical Review  

    Superficial temporal artery (STA) to superior cerebellar artery (SCA) bypass is usually performed via the subtemporal approach (StA), anterior transpetrosal approach (ApA), or combined petrosal approach (CpA), but no study has yet reported a quantitative comparison of the operative field size provided by each approach, and the optimal approach is unclear. The objective of this study is to establish evidence for selecting the approach by using cadaver heads to measure the three-dimensional distances that represent the operative field size for STA–SCA bypass. Ten sides of 10 cadaver heads were used to perform the four approaches: StA, ApA with and without zygomatic arch osteotomy (ApA-ZO− and ApA-ZO+), and CpA. For each approach, the major-axis length and the minor-axis length at the anastomosis site (La-A and Li-A), the major-axis length and the minor-axis length at the brain surface (La-B and Li-B), the depth from the brain surface to the anastomosis site (Dp), and the operating angles of the major axis and the minor axis (OAa and OAi) were measured. Shallower Dp and wider operating angle were obtained in the order CpA, ApA-ZO+, ApA-ZO−, and StA. In all parameters, ApA-ZO− extended the operative field more than StA. ApA-ZO+ extended La-B and OAa more than ApA-ZO−, whereas it did not contribute to Dp and OAi. CpA significantly decreased Dp, and widened OAa and OAi more than ApA-ZO+. ApA and CpA greatly expanded the operative field compared with StA. These results provide criteria for selecting the optimal approach for STA-SCA bypass in light of an individual surgeon’s anastomosis skill level.

    DOI: 10.1007/s10143-021-01686-z

    Web of Science

    Scopus

    PubMed

  35. 特集 脊椎脊髄疾患の再手術症例における手術のコツと留意点 頸椎症における再手術

    西村 由介, 永島 吉孝, 齋藤 竜太

    脊椎脊髄ジャーナル   34 巻 ( 12 ) 頁: 896 - 901   2022年3月

     詳細を見る

    出版者・発行元:三輪書店  

    DOI: 10.11477/mf.5002201765

    CiNii Research

  36. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

    Iwama Shintaro, Kobayashi Tomoko, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Ando Masahiko, Zhou Xin, Yamagami Ayana, Onoue Takeshi, Kawaguchi Yohei, Miyata Takashi, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Wakahara Keiko, Yokota Kenji, Kato Masashi, Nishio Naoki, Tanaka Chie, Miyata Kazushi, Ogura Atsushi, Ito Takanori, Sawada Tsunaki, Shimokata Tomoya, Niimi Kaoru, Ohka Fumiharu, Ishigami Masatoshi, Gotoh Momokazu, Hashimoto Naozumi, Saito Ryuta, Kiyoi Hitoshi, Kajiyama Hiroaki, Ando Yuichi, Hibi Hideharu, Sone Michihiko, Akiyama Masashi, Kodera Yasuhiro, Arima Hiroshi

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   107 巻 ( 4 ) 頁: E1620 - E1630   2022年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:Journal of Clinical Endocrinology and Metabolism  

    Background: Previous studies showed that although the risk of thyroid dysfunction [thyroid immune-related adverse events (irAEs)] induced by anti-programmed cell death-1 antibodies (PD-1-Ab) was as low as 2% to 7% in patients negative for anti-thyroid antibodies (ATAs) at baseline, it was much higher (30%-50%) in patients positive for ATAs. However, whether a similar increase occurs with combination therapy using PD-1-Ab plus anti-cytotoxic T-lymphocyte antigen-4 antibody (CTLA-4-Ab) is unknown. Methods: A total of 451 patients with malignancies treated with PD-1-Ab, CTLA-4-Ab, or a combination of PD-1-Ab and CTLA-4-Ab (PD-1/CTLA-4-Abs) were evaluated for ATAs at baseline and for thyroid function every 6 weeks for 24 weeks after treatment initiation and then observed until the last clinical visit. Results: Of the 451 patients, 51 developed thyroid irAEs after immunotherapy [41 of 416 (9.9%) treated with PD-1-Ab, 0 of 8 (0%) treated with CTLA-4-Ab, and 10 of 27 (37.0%) treated with PD-1/CTLA-4-Abs]. The cumulative incidence of thyroid irAEs was significantly higher in patients who were positive vs negative for ATAs at baseline after both PD-1-Ab [28/87 (32.2%) vs 13/329 (4.0%), P < 0.001] and PD-1/CTLA-4-Abs [6/10 (60.0%) vs 4/17 (23.5%), P < 0.05] treatments. The risk of thyroid irAEs induced by PD-1/CTLA-4Abs, which was significantly higher than that induced by PD-1-Ab, in patients negative for ATAs at baseline was not statistically different from that induced by PD-1-Ab in patients positive for ATAs at baseline. Conclusions: This study showed that the incidence of thyroid irAEs was high and not negligible after PD-1/CTLA-4-Abs treatment even in patients negative for ATAs at baseline.

    DOI: 10.1210/clinem/dgab829

    Web of Science

    Scopus

    PubMed

  37. Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas

    Nishikawa Tomohide, Watanabe Reiko, Kitano Yotaro, Yamamichi Akane, Motomura Kazuya, Ohka Fumiharu, Aoki Kosuke, Hirano Masaki, Kato Akira, Yamaguchi Junya, Maeda Sachi, Kibe Yuji, Saito Ryuta, Wakabayashi Toshihiko, Kato Yukinari, Sato Shuta, Ogino Tomoyoshi, Natsume Atsushi, Ito Ichiro

    BRAIN TUMOR PATHOLOGY   39 巻 ( 1 ) 頁: 14 - 24   2022年1月

     詳細を見る

    記述言語:日本語   出版者・発行元:Brain Tumor Pathology  

    Since the World Health Organization 2016 classification (2016 WHO), genetic status has been incorporated into the diagnosis of Grade 2/3 gliomas (lower-grade gliomas). Therefore, immunohistochemistry (IHC) of IDH1-R132H, ATRX, and p53 have been used in place of genetic status. We report the associations between histological findings, IHC, and genetic status. We performed IHC of IDH1-R132H, ATRX, and p53 in 76 lower-grade gliomas and discussed its validity based on the 2016 WHO and the upcoming 2021 WHO classification. The sensitivity and specificity of anti-ATRX, p53, and IDH1-R132H IHC were 40.9%/98.1%, 78.6%/85.4%, and 90.5%/84.6%, respectively. Among 21 IDH1-mutant gliomas without 1p/19q codeletion, two gliomas (9.5%) mimicked the so-called classic for oligodendroglioma (CFO) in their morphology. Of the 42 gliomas with 1p/19q codeletion, four cases were difficult to diagnose as oligodendroglioma through morphological examination. Moreover, there were three confusing cases with ATRX mutations but with retained ATRX-IHC positivity. The lessons learned from this study are as follows: (1) ATRX-IHC and p53-IHC should be supplementary to morphological diagnosis, (2) rare IDH mutations other than IDH1 R132H should be considered, and (3) there is no complete alternative test to detect molecular features of glioblastoma under the 2021 WHO classification.

    DOI: 10.1007/s10014-021-00418-x

    Web of Science

    Scopus

    PubMed

  38. Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery

    Maesawa Satoshi, Bagarinao Epifanio, Nakatsubo Daisuke, Ishizaki Tomotaka, Takai Sou, Torii Jun, Kato Sachiko, Shibata Masashi, Wakabayashi Toshihiko, Saito Ryuta

    NEUROLOGIA MEDICO-CHIRURGICA   62 巻 ( 1 ) 頁: 45 - 55   2022年1月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurologia Medico-Chirurgica  

    Resting-state functional MRI (rs-fMRI) has been utilized to visualize large-scale brain networks. We evaluated the usefulness of multitier network analysis using rs-fMRI in patients with focal epilepsy. Structural and rs-fMRI data were retrospectively evaluated in 20 cases with medically refractory focal epilepsy, who subsequently underwent surgery. First, structural changes were examined using voxel-based morphometry analysis. Second, alterations in large-scale networks were evaluated using dual-regression analysis. Third, changes in cortical hubs were analyzed and the relationship between aberrant hubs and the epileptogenic zone (EZ) was evaluated. Finally, the relationship between the hubs and the default mode network (DMN) was examined using spectral dynamic causal modeling (spDCM). Dual-regression analysis revealed significant decrease in functional connectivity in several networks including DMN in patients, although no structural difference was seen between groups. Aberrant cortical hubs were observed in and around the EZ (EZ hubs) in 85% of the patients, and a strong degree of EZ hubs correlated to good seizure outcomes postoperatively. In spDCM analysis, facilitation was often seen from the EZ hub to the contralateral side, while inhibition was seen from the EZ hub to nodes of the DMN. Some cognition-related networks were impaired in patients with focal epilepsy. The EZ hub appeared in the vicinity of EZ facilitating connections to distant regions in the early phase, which may eventually generate secondary focus, while inhibiting connections to the DMN, which may cause cognitive deterioration. Our results demonstrate pathological network alterations in epilepsy and suggest that earlier surgical intervention may be more effective.

    DOI: 10.2176/nmc.oa.2021-0173

    Web of Science

    Scopus

    PubMed

    CiNii Research

  39. [Diffuse midline glioma].

    Saito R

    No shinkei geka. Neurological surgery   50 巻 ( 1 ) 頁: 29 - 38   2022年1月

     詳細を見る

    記述言語:日本語   出版者・発行元:株式会社医学書院  

    DOI: 10.11477/mf.1436204529

    PubMed

    CiNii Research

  40. Spontaneous regression of asymptomatic tumefactive perivascular spaces in the anterior temporal lobe

    Hashida M., Nagashima Y., Nishimura Y., Eguchi K., Taoka T., Kawai H., Saito R.

    Nagoya Journal of Medical Science   84 巻 ( 3 ) 頁: 678 - 685   2022年

     詳細を見る

    記述言語:日本語   出版者・発行元:Nagoya Journal of Medical Science  

    Perivascular spaces are fluid-filled spaces that surround the perforating vessels of the brain and are normal findings on brain imaging. These are usually asymptomatic and are considered a manifestation of aging. Perivascular spaces occasionally undergo significant enlargement and are referred to as tumefactive perivascular spaces, which are often indistinguishable from neoplastic lesions. Spontaneous regression of tumefactive perivascular spaces during follow-up is rare. We report the imaging findings and clinical course of a patient who showed spontaneous regression of tumefactive perivascular spaces in the anterior temporal lobe, together with a literature review and discussion regarding the characteristics and pathogenesis of spontaneous regression of tumefactive perivascular spaces. Most studies in the available literature report tumefactive perivascular spaces in the anterior temporal lobe; in our view, the characteristics of anterior temporal lobe tumefactive perivascular spaces may differ from those of tumefactive perivascular spaces that occur at other locations.

    DOI: 10.18999/nagjms.84.3.678

    Scopus

  41. 胸部大動脈ステントグラフト治療の既往がある急性主幹動脈閉塞症に対しsurgical embolectomyが奏功した1例

    村松 佑亮, 布施 佑太郎, 太田 慎次, 中村 茂和, 栗本 太志, 渡邉 和彦, 齋藤 竜太

    脳卒中   advpub 巻 ( 0 )   2022年

     詳細を見る

    記述言語:日本語   出版者・発行元:一般社団法人 日本脳卒中学会  

    <p>症例は83歳男性.突然の右半身麻痺および失語を呈し,当院に救急搬送された.来院時,全失語,右半身完全麻痺の状態であった.頭部造影CTと脳MRIで左MCA急性閉塞を認めた.機械的血栓回収療法を検討したが,胸部大動脈瘤に対するステントグラフト留置(thoracic endovascular aortic repair: TEVAR)の既往があり,経大動脈的アプローチは困難と予測された.そのため,緊急で顕微鏡下のsurgical embolectomyを施行した.術後症状は著明に改善し,NIHSS 3点,mRS 2点で自宅退院となった.発症から来院までの時間が短いMCA急性閉塞症に対して,機械的血栓回収療法のリスクが高い場合にsurgical embolectomyを行い,良好な転帰を得た.急性期脳主幹動脈閉塞に対して,大動脈アプローチが困難と予想される場合には,surgical embolectomyをはじめから治療の選択肢に加えることを検討してもよいかもしれない.</p>

    DOI: 10.3995/jstroke.11028

    CiNii Research

  42. Contrast-Enhanced Magnetic Resonance Imaging Suggested a Possibility of Transvenous Embolization in the Superior Petrosal Sinus Dural Arteriovenous Fistula: A Case Report

    Nishihori Masahiro, Izumi Takashi, Tsukada Tetsuya, Kato Yutaka, Uda Kenji, Yokoyama Kinya, Araki Yoshio, Saito Ryuta

    Journal of Neuroendovascular Therapy   16 巻 ( 3 ) 頁: 163 - 169   2022年

     詳細を見る

    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective</b>: Superior petrosal sinus dural arteriovenous fistula (SPS-DAVF) is a rare subtype of intracranial DAVF that sometimes leads to hemorrhagic symptoms following deep venous drainage. Here we report the case of SPS-DAVF with retrograde venous reflux to the cerebellar vein. Preoperative contrast-enhanced MRI was a decisive factor in a safe and effective treatment.</p><p><b>Case Presentation</b>: A 37-year-old woman was referred to our hospital with abnormal MRI findings, which was performed when she had a mild headache during her check-up. DSA revealed left-sided SPS-DAVF, which was diagnosed as Cognard type IIb. Both CTA and DSA could not detect the whole SPS but only the shunt pouch. Using contrast-enhanced MRI, we were able to visualize the presence of the SPS and its continuity within the shunt pouch. 3D-T1 turbo spin echo (SPACE) showed a low-intensity area in the SPS, which was not seen in the 3D-T1 fast field echo (FFE). During the procedure, there was a point where it was difficult to advance the microcatheter, which coincided with the low-intensity area. We achieved effective transvenous embolization from the occluded venous access by devising a surgical technique.</p><p><b>Conclusion</b>: In addition to the contrast-enhanced 3D-T1 FFE, 3D-T1 SPACE might provide beneficial information for endovascular therapy in the evaluation of venous sinuses, which could not be detected by standard examinations.</p>

    DOI: 10.5797/jnet.cr.2021-0029

    CiNii Research

  43. Atypical Incomplete Detachment Following PulseRider Deployment

    Goto Shunsaku, Izumi Takashi, Nishihori Masahiro, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Saito Ryuta

    Journal of Neuroendovascular Therapy   16 巻 ( 8 ) 頁: 409 - 412   2022年

     詳細を見る

    記述言語:英語   出版者・発行元:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective</b>: Owing to the limited time since the introduction of the PulseRider (PR), inconsequential or rare complications that clinicians should be aware of remain unreported yet. Here, we report a rare complication of incomplete detachment.</p><p><b>Case Presentation</b>: A 50-year-old male underwent PR-assisted coil embolization for a basilar tip aneurysm. Coiling was completed, and the detachment procedure was performed using a detachment machine; the success signal was observed. The delivery microcatheter was subsequently advanced back up to the proximal markers, and no reapproximation of the proximal markers, which indicates successful detachment, was observed. However, only one of the proximal markers returned to the microcatheter, and incomplete detachment of only one leg was detected. Ultimately, electrical detachment was not possible, and physical separation by tension was achieved.</p><p><b>Conclusion</b>: Our case report presents a rare case of a detachment problem in the PR. The PR could not be detached, although the signal revealed successful detachment. Therefore, careful withdrawal of the delivery wire by checking not only the proximal markers but also the behavior of the entire PR and coil complex is important.</p>

    DOI: 10.5797/jnet.cr.2021-0095

    CiNii Research

  44. 頚椎症性脊髄症が疑われたACTH単独欠損症の1例

    齋藤 剛, 吉田 光宏, 中林 規容, 相見 有理, 石田 衛, 濱﨑 一, 寺尾 和一, 中嶋 祥子, 苗代 朋樹, 齋藤 竜太

    脊髄外科   36 巻 ( 1 ) 頁: 88 - 93   2022年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本脊髄外科学会  

    DOI: 10.2531/spinalsurg.36.88

    CiNii Research

  45. Laminectomy triggers symptomatic growth of spinal schwannoma in a patient with schwannomatosis.

    Oyama T, Nishimura Y, Nagashima Y, Nishii T, Hara M, Takayasu M, Sakakibara A, Saito R

    Surgical neurology international   13 巻   頁: 261   2022年

     詳細を見る

    記述言語:英語  

    DOI: 10.25259/SNI_453_2022

    PubMed

  46. Clinical and Radiological Clues of Traumatic Craniocervical Junction Injuries Requiring Occipitocervical Fusion to Early Diagnosis

    Shiraishi Daimon, Nishimura Yusuke, Aguirre-Carreno Isaac, Hara Masahito, Yoshikawa Satoshi, Eguchi Kaoru, Nagashima Yoshitaka, Ito Hiroshi, Haimoto Shoichi, Yamamoto Yu, Ginsberg Howard J., Takayasu Masakazu, Saito Ryuta

    NEUROSPINE   18 巻 ( 4 ) 頁: 741 - 748   2021年12月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurospine  

    Objective: The purpose of this study is to find the clinical and radiographic characteristics of traumatic craniocervical junction (CCJ) injuries requiring occipitocervical fusion (OC fusion) for early diagnosis and surgical intervention. Methods: We retrospectively reviewed 12 patients with CCJ injuries presenting to St. Mi-chaels Hospital in Toronto who underwent OC fusion and looked into the following vari-ables; (1) initial trauma data on emergency room arrival, (2) associated injuries, (3) imaging characteristics of computed tomography (CT) scan and magnetic resonance imaging (MRI), (4) surgical procedures, surgical complications, and neurological outcome. Results: All patients were treated as acute spinal injuries and underwent OC fusion on an emergency basis. Patients consisted of 10 males and 2 females with an average age of 47 years (range, 18–82 years). All patients sustained high-energy injuries. Three patients out of 6 patients with normal BAI (basion-axial interval) and BDI (basion-dens interval) values showed visible CCJ injuries on CT scans. However, the remaining 3 patients had no clear evidence of occipitoatlantal instability on CT scans. MRI clearly described several findings indicating occipitoatlantal instability. The 8 patients with normal values of ADI (atlanto-dens interval interval) demonstrated atlantoaxial instability on CT scan, however, all MRI more clearly and reliably demonstrated C1/2 facet injury and/or cruciate ligament injury. Conclusion: We advocate measures to help recognize CCJ injury at an early stage in the present study. Occipitoatlantal instability needs to be carefully investigated on MRI in addition to CT scan with special attention to facet joint and ligament integrity.

    DOI: 10.14245/ns.2142860.430

    Web of Science

    Scopus

    PubMed

  47. Two cases of solitary fibrous tumor/hemangiopericytoma with different clinical features according to the World Health Organization classification: case report and review of the literature.

    Nishii T, Nagashima Y, Nishimura Y, Ito H, Oyama T, Matsuo M, Sakakibara A, Shimada S, Saito R

    Journal of spine surgery (Hong Kong)   7 巻 ( 4 ) 頁: 532 - 539   2021年12月

     詳細を見る

    記述言語:英語  

    DOI: 10.21037/jss-21-83

    PubMed

  48. A Super-selective Wada Test Successfully Detected an Artery That Supplied Broca's Area in a Case of Left Frontal Lobe Glioblastoma: Technical Case Report.

    Yamashita S, Saito R, Osawa SI, Niizuma K, Ukishiro K, Kanamori M, Kakinuma K, Suzuki K, Tominaga T

    Neurologia medico-chirurgica   61 巻 ( 11 ) 頁: 661 - 666   2021年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2176/nmc.tn.2021-0054

    PubMed

  49. Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging

    Maesawa Satoshi, Mizuno Satomi, Bagarinao Epifanio, Watanabe Hirohisa, Kawabata Kazuya, Hara Kazuhiro, Ohdake Reiko, Ogura Aya, Mori Daisuke, Nakatsubo Daisuke, Isoda Haruo, Hoshiyama Minoru, Katsuno Masahisa, Saito Ryuta, Ozaki Norio, Sobue Gen

    FRONTIERS IN HUMAN NEUROSCIENCE   15 巻   頁: 753836   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:Frontiers in Human Neuroscience  

    Purpose: Maintenance of cognitive performance is important for healthy aging. This study aims to elucidate the relationship between brain networks and cognitive function in subjects maintaining relatively good cognitive performance. Methods: A total of 120 subjects, with equal number of participants from each age group between 20 and 70 years, were included in this study. Only participants with Addenbrooke’s Cognitive Examination – Revised (ACE-R) total score greater than 83 were included. Anatomical T1-weighted MR images and resting-state functional MR images (rsfMRIs) were taken from all participants using a 3-tesla MRI scanner. After preprocessing, several factors associated with age including the ACE-R total score, scores of five domains, sub-scores of ACE-R, and brain volumes were tested. Morphometric changes associated with age were analyzed using voxel based morphometry (VBM) and changes in resting state networks (RSNs) were examined using dual regression analysis. Results: Significant negative correlations with age were seen in the total gray matter volume (GMV, r = −0.58), and in the memory, attention, and visuospatial domains. Among the different sub-scores, the score of the delayed recall (DR) showed the highest negative correlation with age (r = −0.55, p < 0.001). In VBM analysis, widespread regions demonstrated negative correlation with age, but none with any of the cognitive scores. Quadratic approximations of cognitive scores as functions of age showed relatively delayed decline compared to total GMV loss. In dual regression analysis, some cognitive networks, including the dorsal default mode network, the lateral dorsal attention network, the right / left executive control network, the posterior salience network, and the language network, did not demonstrate negative correlation with age. Some regions in the sensorimotor networks showed positive correlation with the DR, memory, and fluency scores. Conclusion: Some domains of the cognitive test did not correlate with age, and even the highly correlated sub-scores such as the DR score, showed delayed decline compared to the loss of total GMV. Some RSNs, especially involving cognitive control regions, were relatively maintained with age. Furthermore, the scores of memory, fluency, and the DR were correlated with the within-network functional connectivity values of the sensorimotor network, which supported the importance of exercise for maintenance of cognition.

    DOI: 10.3389/fnhum.2021.753836

    Web of Science

    Scopus

    PubMed

  50. Aphasic status epilepticus after glioma resection: two case reports. 国際誌

    Shimoda Y, Kanamori M, Saito R, Osawa S, Mugikura S, Tominaga T

    Acta neurochirurgica   163 巻 ( 11 ) 頁: 3109 - 3113   2021年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00701-021-04984-z

    PubMed

  51. Techniques, Indications, and Outcomes in Magnetic Resonance-guided Focused Ultrasound Thalamotomy for Tremor

    Maesawa Satoshi, Nakatsubo Daisuke, Tsugawa Takahiko, Kato Sachiko, Shibata Masashi, Takai Sou, Torii Jun, Ishizaki Tomotaka, Wakabayashi Toshihiko, Saito Ryuta

    NEUROLOGIA MEDICO-CHIRURGICA   61 巻 ( 11 ) 頁: 629 - 639   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurologia Medico-Chirurgica  

    Magnetic resonance (MR)-guided focused ultrasound surgery (MRgFUS) is the latest minimally invasive stereotactic procedure, and thalamotomy using this novel modality has demonstrated its effectiveness and safety, especially for patients with essential tremor (ET) and Parkinson’s disease (PD). In Japan, the application of MRgFUS to treat ET and PD has recently been covered by health insurance. Technically, the transducer with 1024 elements emits ultrasound beams, which are then focused on the target with a phase control, resulting in optimal ablation by thermal coagulation. The technical advantages of MRgFUS are continuous intraoperative monitoring of clinical symptoms and MR images and fine adjustment of the target by the steering function. Postoperative tremor control is compatible with other modalities, although long-term follow-up is necessary. The adverse effects are usually transient and acceptable. Prognostic factors for good tremor control include high temperature and large lesion size. A high skull density ratio is a factor to achieve high temperature and large lesioning, but it may not be necessary and sufficient for clinical outcomes. For patients with advanced symptoms such as bilateral tremor or head/neck tremor, deep brain stimulation may be recommended because of the adjustability of stimulation and the possibility of bilateral treatment. Patients have high expectations of MRgFUS because of its non-invasiveness. To perform this treatment safely and effectively, physicians need to understand the technological aspects, the physiological principles. To choose the appropriate modality, physicians also should recognize the clinical advantages and disadvantages of MRgFUS compared to other modalities.

    DOI: 10.2176/nmc.ra.2021-0187

    Web of Science

    Scopus

    PubMed

    CiNii Research

  52. Newly established patient-derived organoid model of intracranial meningioma

    Yamazaki Shintaro, Ohka Fumiharu, Hirano Masaki, Shiraki Yukihiro, Motomura Kazuya, Tanahashi Kuniaki, Tsujiuchi Takashi, Motomura Ayako, Aoki Kosuke, Shinjo Keiko, Murofushi Yoshiteru, Kitano Yotaro, Maeda Sachi, Kato Akira, Shimizu Hiroyuki, Yamaguchi Junya, Adilijiang Alimu, Wakabayashi Toshihiko, Saito Ryuta, Enomoto Atsushi, Kondo Yutaka, Natsume Atsushi

    NEURO-ONCOLOGY   23 巻 ( 11 ) 頁: 1936 - 1948   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neuro-Oncology  

    Background: Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific molecular alterations have not yet been identified because of the limited number of representative research models of meningiomas. Methods: We performed organoid cultures using meningioma cells and meningioma tumor tissues. Using immunohistochemistry and molecular analyses consisting of whole-exome sequencing, RNA-seq, and DNA methylation analyses, we compared the histological findings and molecular profiling of organoid models with those of parental tumors. Further, using these organoid models together with a public database of meningiomas, we explored molecular alterations, which are a potent treatment target for meningioma. Results: We established 18 organoid models comprising of two malignant meningioma cells (HKBMM and IOMM-Lee), 10 benign meningiomas, four malignant meningiomas, and two solitary fibrous tumors (SFTs). The organoids exhibited consistent histological features and molecular profiles with those of the parental tumors. Using a public database, we identified that upregulated forkhead box M1 (FOXM1) was correlated with increased tumor proliferation. Overexpression of FOXM1 in benign meningioma organoids increased organoid proliferation; depletion of FOXM1 in malignant organoids decreased proliferation. Additionally, thiostrepton, a FOXM1 inhibitor combined with radiation therapy, significantly inhibited the proliferation of malignant meningioma organoid models. Conclusions: An organoid model for meningioma enabled us to elucidate the tumor biology of meningioma along with potent treatment targets for meningioma.

    DOI: 10.1093/neuonc/noab155

    Web of Science

    Scopus

    PubMed

  53. Effects of oxytocin on responses to nociceptive and non-nociceptive stimulation in the upper central nervous system

    Saito Hidehisa, Hidema Shizu, Otsuka Ayano, Suzuki Jun, Kumagai Michio, Kanaya Akihiro, Murakami Toru, Takei Yusuke, Saito Kazutomo, Sugino Shigekazu, Toyama Hiroaki, Saito Ryuta, Tominaga Teiji, Nishimori Katsuhiko, Yamauchi Masanori

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   574 巻   頁: 8 - 13   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:Biochemical and Biophysical Research Communications  

    Oxytocin is known as a social bonding hormone, but it also functions as an anxiolytic or analgesic neurotransmitter. When oxytocin regulates pain or anxiousness centrally as a neurotransmitter, it is secreted by neurons and directly projected to targeted regions. Although the function of oxytocin at the spinal level is well studied, its effects at the supraspinal level are poorly understood. We aimed to investigate the effect of oxytocin at the supraspinal level in vivo using C57BL/6J (wild-type [WT]), oxytocin-deficient (Oxt−/−), oxytocin receptor-deficient (Oxtr−/−), and oxytocin receptor-Venus (OxtrVenus/+) mice lines. Response thresholds in Oxtr−/− mice in Hargreaves and von-Frey tests were significantly lower than those in WT mice, whereas open field and light/dark tests showed no significant differences. Moreover, response thresholds in Oxt−/− mice were raised to those in WT mice after oxytocin administration. Following the Hargreaves test, we observed the co-localisation of c-fos with Venus or the oxytocin receptor in the periaqueductal gray (PAG), medial amygdala (MeA), and nucleus accumbens (NAc) regions in OxtrVenus/+ mice. Furthermore, in the PAG, MeA, and NAc regions, the co-localisation of oxytocin with c-fos and gamma-aminobutyric acid was much stronger in Oxtr−/− mice than in WT mice. However, following von-Frey test, the same findings were observed only in the MeA and NAc regions. Our results suggest that oxytocin exerts its analgesic effect on painful stimulation via the PAG region and a self-protective effect on unpleasant stimulation via the MeA and NAc regions.

    DOI: 10.1016/j.bbrc.2021.08.042

    Web of Science

    Scopus

    PubMed

  54. Triggering of Carotid Sinus Reflex during Deployment the Flow-diverter Device

    Goto Shunsaku, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Araki Yoshio, Uda Kenji, Yokoyama Kinya, Saito Ryuta

    NEUROLOGIA MEDICO-CHIRURGICA   61 巻 ( 10 ) 頁: 583 - 590   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:Neurologia Medico-Chirurgica  

    The carotid sinus reflex (CSR) is a rare complication of the Pipeline Embolization Device (PED) deployment. No study has assessed the potential risk factors in a case series. The purpose of this study was to examine CSR triggering during PED deployment. Thirty-seven consecutive patients who underwent PED deployment were included. All procedures were performed under local anesthesia with mild sedation. We retrospectively analyzed patient characteristics, PED deployment time, and vital signs during the procedure. The vital signs included the pulse rate (PR) and systolic blood pressure (SBP) obtained at three timepoints (pre-deployment, during deployment, post-deployment). We examined the triggering of the CSR during PED deployment by comparing the vital signs at the three timepoints. Moreover, risk factors for CSR were analyzed with univar-iate analysis. The patients’ average age was 66.3 years. The average size of the aneurysm was 18.0 mm. Six patients (16.2%) showed a decline in the SBP or PR defined as CSR. One patient had a transient cardiac arrest and two had severe transient bradycardia. Deployment into the ophthalmic segment of the internal carotid artery (C2 segment) aneurysm (p = 0.022), prolonged PED deployment time more than 14.5 minutes (p = 0.005), and an acute angle of the anterior genu less than 51.5 degrees (p = 0.005) were risk factors in triggering CSR. CSR may be triggered during PED deployment under local anesthesia with mild sedation. Deployment to the C2 segment aneu-rysm, prolonged PED deployment time, and an acute angle of the anterior genu were associated with CSR triggering.

    DOI: 10.2176/nmc.oa.2021-0049

    Web of Science

    Scopus

    PubMed

    CiNii Research

  55. Sellar arachnoid cystに対する経鼻内視鏡手術

    永田 雄一, 竹内 和人, 山本 太樹, 水野 晃宏, 永谷 哲也, 齋藤 竜太

    日本内分泌学会雑誌   97 巻 ( S.HPT ) 頁: 49 - 51   2021年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:一般社団法人 日本内分泌学会  

    DOI: 10.1507/endocrine.97.s.hpt_49

    CiNii Research

  56. 内視鏡下経鼻頭蓋底手術後の再建戦略

    竹内 和人, 永田 雄一, 山本 太樹, 原田 英幸, 齋藤 竜太

    日本内分泌学会雑誌   97 巻 ( S.HPT ) 頁: 16 - 18   2021年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:一般社団法人 日本内分泌学会  

    DOI: 10.1507/endocrine.97.s.hpt_16

    CiNii Research

  57. Mathematical Modeling and Mutational Analysis Reveal Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas

    Aoki Kosuke, Suzuki Hiromichi, Yamamoto Takashi, Yamamoto Kimiyo N., Maeda Sachi, Okuno Yusuke, Ranjit Melissa, Motomura Kazuya, Ohka Fumiharu, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Shimizu Hiroyuki, Kitano Yotaro, Yamaguchi Junya, Yamazaki Shintaro, Nakamura Hideo, Takahashi Masamichi, Narita Yoshitaka, Nakada Mitsutoshi, Deguchi Shoichi, Mizoguchi Masahiro, Momii Yasutomo, Muragaki Yoshihiro, Abe Tatsuya, Akimoto Jiro, Wakabayashi Toshihiko, Saito Ryuta, Ogawa Seishi, Haeno Hiroshi, Natsume Atsushi

    CANCER RESEARCH   81 巻 ( 18 ) 頁: 4861 - 4873   2021年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:Cancer Research  

    Isocitrate dehydrogenase-mutant low-grade gliomas (IDHmut- LGG) grow slowly but frequently undergo malignant transformation, which eventually leads to premature death. Chemotherapy and radiotherapy treatments prolong survival, but can also induce genetic (or epigenetic) alterations involved in transformation. Here, we developed a mathematical model of tumor progression based on serial tumor volume data and treatment history of 276 IDHmut- LGGs classified by chromosome 1p/19q codeletion (IDHmut/ 1p19qcodel and IDHmut/1p19qnoncodel) and performed genomewide mutational analyses, including targeted sequencing and longitudinal whole-exome sequencing data. These analyses showed that tumor mutational burden correlated positively with malignant transformation rate, and chemotherapy and radiotherapy significantly suppressed tumor growth but increased malignant transformation rate per cell by 1.8 to 2.8 times compared with before treatment. This model revealed that prompt adjuvant chemoradiotherapy prolonged malignant transformation-free survival in small IDHmut-LGGs (≤ 50 cm3). Furthermore, optimal treatment differed according to genetic alterations for large IDHmut-LGGs (> 50 cm3); adjuvant therapies delayed malignant transformation in IDHmut/1p19qnoncodel but often accelerated it in IDHmut/1p19qcodel. Notably, PI3K mutation was not associated with malignant transformation but increased net postoperative proliferation rate and decreased malignant transformation-free survival, prompting the need for adjuvant therapy in IDHmut/1p19qcodel. Overall, this model uncovered therapeutic strategies that could prevent malignant transformation and, consequently, improve overall survival in patients with IDHmut-LGGs.

    DOI: 10.1158/0008-5472.CAN-21-0985

    Web of Science

    Scopus

    PubMed

  58. [Magnetic Resonance-guided Focused Ultrasound Ablation:Techniques and Neurological Applications].

    Maesawa S, Nakatsubo D, Tsugawa T, Kato S, Shibata M, Takai S, Torii J, Wakabayashi T, Saito R

    No shinkei geka. Neurological surgery   49 巻 ( 4 ) 頁: 847 - 856   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:株式会社医学書院  

    DOI: 10.11477/mf.1436204463

    PubMed

    CiNii Research

  59. Association between IDH mutational status and tumor-associated epilepsy or venous thromboembolism in patients with grade II and III astrocytoma.

    Osada Y, Saito R, Miyata S, Shoji T, Shibahara I, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T

    Brain tumor pathology   38 巻 ( 3 ) 頁: 218 - 227   2021年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10014-021-00406-1

    PubMed

    その他リンク: https://link.springer.com/article/10.1007/s10014-021-00406-1/fulltext.html

  60. 頭蓋内胚腫治療後にてんかんを発症した症例群の検討

    下田 由輝, 金森 政之, 大沢 伸一郎, 齋藤 竜太, 園田 順彦, 隈部 俊宏, 中里 信和, 冨永 悌二

    てんかん研究   39 巻 ( 2 ) 頁: 305 - 305   2021年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本てんかん学会  

  61. Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping

    Motomura Kazuya, Chalise Lushun, Ohka Fumiharu, Aoki Kosuke, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Yamaguchi Junya, Shimizu Hiroyuki, Wakabayashi Toshihiko, Saito Ryuta

    JOURNAL OF NEURO-ONCOLOGY   153 巻 ( 2 ) 頁: 361 - 372   2021年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:Journal of Neuro-Oncology  

    Purpose: The aim of this study was to assess the effect of the extent of resection (EOR) of tumors on survival in a series of patients with grade II and III gliomas (GII/III-gliomas) who underwent awake brain mapping. Methods: We retrospectively analyzed 126 patients with GII/III-gliomas in the dominant and non-dominant hemisphere who underwent awake brain surgery at the same institution between December 2012 and May 2020. Results: EOR cut-off values for improved progression-free survival (PFS) were determined by a receiver operator characteristic (ROC) analysis of 5-year PFS. The ROC for EOR showed a cut-off value of ≥ 85.3%. The median PFS rate of patients with GII/III-gliomas in the group with an EOR ≥ 100%, including supratotal resection (n = 47; median survival [MS], not reached), was significantly higher than that in the group with an EOR < 90% (n = 52; MS, 43.1 months; 95% CI 37.7–48.5 months; p = 0.03). In patients with diffuse astrocytomas and anaplastic astrocytomas, the group with EOR ≥ 100%, including supratotal resection (n = 25; MS, not reached), demonstrated a significantly better PFS rate than did the group with an EOR < 100% (n = 45; MS, 35.8 months; 95% CI 19.9–51.6 months; p = 0.03). Supratotal or gross total resection was correlated with better PFS in IDH-mutant type of diffuse astrocytomas and anaplastic astrocytomas (n = 19; MS, not reached vs. n = 35; MS, 40.6 months; 95% CI 22.3–59.0 months; p = 0.02). By contrast, supratotal or gross total resection was not associated with longer PFS rates in patients with IDH-wild type of diffuse astrocytomas and anaplastic astrocytomas. Conclusions: The present study demonstrates a significant association between tumor EOR and survival in patients with GII/III gliomas. The EOR cut-off value for 5-year PFS was ≥ 85.3%. It is noteworthy that supratotal or gross total resection significantly correlated with better PFS in IDH-mutant type of WHO grade II and III astrocytic tumors. In light of our finding that EOR did not correlate with PFS in patients with aggressive IDH-wild type of diffuse astrocytomas and anaplastic astrocytomas, we suggest treatments that are more intensive will be needed for the control of these tumors.

    DOI: 10.1007/s11060-021-03776-w

    Web of Science

    Scopus

    PubMed

  62. Orengedokuto and shosaikoto for intractable intracranial carmustine implant-induced fever in a patient with brain tumor: A case report. 国際誌

    Suzuki S, Takayama S, Kikuchi A, Arita R, Abe M, Saito R, Kanamori M, Tominaga T, Ishii T

    Explore (New York, N.Y.)   17 巻 ( 3 ) 頁: 236 - 238   2021年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.explore.2020.08.014

    PubMed

  63. Postcentral gyrus resection of opercular gliomas is a risk factor for motor deficits caused by damaging the radiologically invisible arteries supplying the descending motor pathway.

    Shibahara I, Sato S, Hide T, Saito R, Kanamori M, Sonoda Y, Tominaga T, Kumabe T

    Acta neurochirurgica   163 巻 ( 5 ) 頁: 1269 - 1278   2021年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00701-021-04737-y

    PubMed

    その他リンク: https://link.springer.com/article/10.1007/s00701-021-04737-y/fulltext.html

  64. [Chemotherapy for Glioma].

    Saito R

    No shinkei geka. Neurological surgery   49 巻 ( 3 ) 頁: 588 - 596   2021年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:株式会社医学書院  

    DOI: 10.11477/mf.1436204432

    PubMed

    CiNii Research

  65. Effect of endoscope flexibility on tissue dissection profile assessed with pulsed water jet device: ensuring safety, efficacy, and handling of thin devices for neuroendoscopic surgery. 国際誌

    Kusunoki T, Kawaguchi T, Nakagawa A, Noguchi Y, Osawa SI, Endo H, Endo T, Saito R, Kanamori M, Niizuma K, Tominaga T

    BMC research notes   14 巻 ( 1 ) 頁: 64 - 64   2021年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s13104-021-05475-1

    PubMed

  66. Hepatitis B virus reactivation during temozolomide administration for malignant glioma.

    Shoji T, Kanamori M, Inoue J, Saito R, Osada Y, Shimoda Y, Chonan M, Uenohara H, Masamune A, Tominaga T

    International journal of clinical oncology   26 巻 ( 2 ) 頁: 305 - 315   2021年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10147-020-01814-7

    PubMed

  67. H3K27M and <i>TERT</i> promoter mutations are poor prognostic factors in surgical cases of adult thalamic high-grade glioma.

    Osada Y, Saito R, Shibahara I, Sasaki K, Shoji T, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T

    Neuro-oncology advances   3 巻 ( 1 ) 頁: vdab038   2021年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/noajnl/vdab038

    PubMed

    その他リンク: http://academic.oup.com/noa/article-pdf/3/1/vdab038/37929606/vdab038.pdf

  68. Corpus Callosum Swelling after Resection of Intraventricular Central Neurocytoma.

    Aburakawa D, Kanamori M, Akashi T, Sato S, Saito R, Tominaga T

    NMC case report journal   8 巻 ( 1 ) 頁: 535 - 543   2021年

     詳細を見る

    記述言語:英語  

    DOI: 10.2176/nmccrj.cr.2020-0369

    PubMed

  69. アクセス困難な硬膜動静脈瘻症例における,対側上錐体静脈洞を経由する上錐体静脈洞へのアプローチ

    鈴木 啓太, 西堀 正洋, 泉 孝嗣, 鈴木 宰, 武藤 学, 荒木 芳生, 宇田 憲司, 横山 欣也, 齋藤 竜太

    脳血管内治療   6 巻 ( 3 ) 頁: 161 - 168   2021年

     詳細を見る

    記述言語:日本語   出版者・発行元:特定非営利活動法人 日本脳神経血管内治療学会  

    <p>【目的】多発硬膜動静脈瘻(dural arteriovenous fistula: DAVF)の症例において,左上錐体静脈洞部(superior petrosal sinus: SPS)のシャントを右 SPS 経由で塞栓した症例を報告する.【症例】60 歳女性,意識障害の精査にて深部静脈逆流を伴う多発 DAVF を認めた.逆流に最も関与する左横静脈洞部 DAVF に対して経静脈的塞栓術を施行した.術後症状改善が乏しく,再度DSA を行うと,左 SPS へのシャントと深部静脈への逆流が明らかとなった.左横静脈洞と両側下錐体静脈洞は閉塞していたため,右 SPS と両側海綿静脈洞を経由してマイクロカテーテルをシャント部へ誘導し,左 SPS を塞栓し,逆流の消失を得た.【結論】対側 SPS を経由した SPS へのアクセスは,同側からのアクセスが困難な症例において,有効な選択肢になり得る.</p>

    DOI: 10.20626/nkc.tn.2021-0009

    CiNii Research

  70. 覚醒下手術中痙攣発作コントロールにおけるレベチラセタム・ペランパネル併用療法の有効性について

    本村 和也, 齋藤 竜太

    神経治療学   38 巻 ( 6 ) 頁: S211 - S211   2021年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本神経治療学会  

    DOI: 10.15082/jsnt.38.6_s211

    CiNii Research

  71. Unilateral chronic subdural hematoma due to spontaneous intracranial hypotension: a report of four cases. 査読有り 国際誌

    Osada Y, Shibahara I, Nakagawa A, Sakata H, Niizuma K, Saito R, Kanamori M, Fujimura M, Suzuki S, Tominaga T

    British journal of neurosurgery   34 巻 ( 6 ) 頁: 632 - 637   2020年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/02688697.2019.1667482

    PubMed

  72. A multinodular and vacuolating neuronal tumor in the right temporal lobe with positive methionine uptake: A case report

    Taketo Nishizawa, Ryuta Saito, Masashi Chonan, Masayuki Kanamori, Kentaro Takanami, Mika Watanabe, Teiji Tominaga

    Interdisciplinary Neurosurgery: Advanced Techniques and Case Management   22 巻   2020年12月

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

    Multinodular and vacuolating neuronal tumor (MVNT) is a recently recognized type of neural tumor that was first documented in 2013. This tumor type is characterized by multiple nodules of neuronal cells with vacuolar degeneration localized in the subcortical white matter. Here, we report a case of MVNT in the right temporal lobe of a 26-year-old female. Magnetic resonance imaging (MRI) revealed a high-intensity lesion on a T2- weighted image of the right temporal lobe without contrast enhancement. Positron emission tomography revealed increased 11C-methionine uptake in the lesion, which was pathologically diagnosed as MVNT.

    DOI: 10.1016/j.inat.2020.100861

    Scopus

  73. TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations.

    Arita H, Matsushita Y, Machida R, Yamasaki K, Hata N, Ohno M, Yamaguchi S, Sasayama T, Tanaka S, Higuchi F, Iuchi T, Saito K, Kanamori M, Matsuda KI, Miyake Y, Tamura K, Tamai S, Nakamura T, Uda T, Okita Y, Fukai J, Sakamoto D, Hattori Y, Pareira ES, Hatae R, Ishi Y, Miyakita Y, Tanaka K, Takayanagi S, Otani R, Sakaida T, Kobayashi K, Saito R, Kurozumi K, Shofuda T, Nonaka M, Suzuki H, Shibuya M, Komori T, Sasaki H, Mizoguchi M, Kishima H, Nakada M, Sonoda Y, Tominaga T, Nagane M, Nishikawa R, Kanemura Y, Kuchiba A, Narita Y, Ichimura K

    Acta neuropathologica communications   8 巻 ( 1 ) 頁: 201   2020年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s40478-020-01078-2

    PubMed

  74. がん遺伝子パネル検査でSMARCB1変異を認め、INI-1蛋白陽性のAT/RTと考えられた一例(Clinical sequencing revealed two distinct mutations in SMARCB1, in an INI-1 positive AT/RT)

    Kaino Akira, Niizuma Hidetaka, Moriya Kunihiko, Katayama Saori, Irie Masahiro, Rikiishi Takeshi, Saito Ryuta, Kanamori Masayuki, Sasahara Yoji, Kure Shigeo

    日本小児血液・がん学会雑誌   57 巻 ( 4 ) 頁: 245 - 245   2020年10月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本小児血液・がん学会  

  75. Frequent Clinical and Radiological Progression of Optic Pathway/Hypothalamic Pilocytic Astrocytoma in Adolescents and Young Adults. 査読有り

    Shoji T, Kanamori M, Saito R, Watanabe Y, Watanabe M, Fujimura M, Ogawa Y, Sonoda Y, Kumabe T, Kure S, Tominaga T

    Neurologia medico-chirurgica   60 巻 ( 6 ) 頁: 277 - 285   2020年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2176/nmc.oa.2019-0208

    PubMed

  76. Regression of Recurrent Spinal Cord High-Grade Glioma After Convection-Enhanced Delivery of Nimustine Hydrochloride: Case Reports and Literature Review.

    Endo T, Inoue T, Sugiyama S, Saito R, Tominaga T

    Operative neurosurgery (Hagerstown, Md.)   18 巻 ( 4 ) 頁: 451 - 459   2020年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/ons/opz172

    PubMed

  77. 髄芽腫の放射線療法中に合併した難治性ITPに対し,rituximabが奏功した一例

    戒能 明, 新妻 秀剛, 入江 正寛, 片山 紗乙莉, 森谷 邦彦, 力石 健, 齋藤 竜太, 金森 政之, 笹原 洋二, 呉 繁夫

    日本小児科学会雑誌   124 巻 ( 2 ) 頁: 321 - 321   2020年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

  78. 髄芽腫の放射線療法中に合併した難治性ITPに対し,rituximabが奏功した一例

    戒能 明, 新妻 秀剛, 入江 正寛, 片山 紗乙莉, 森谷 邦彦, 力石 健, 齋藤 竜太, 金森 政之, 笹原 洋二, 呉 繁夫

    日本小児科学会雑誌   124 巻 ( 2 ) 頁: 321 - 321   2020年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

  79. Experience of Low Dose Perampanel to Add-on in Glioma Patients with Levetiracetam-uncontrollable Epilepsy. 査読有り

    Chonan M, Saito R, Kanamori M, Osawa SI, Watanabe M, Suzuki H, Nakasato N, Tominaga T

    Neurologia medico-chirurgica   60 巻 ( 1 ) 頁: 37 - 44   2020年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2176/nmc.oa.2018-0245

    PubMed

  80. Phase I trial of convection-enhanced delivery of nimustine hydrochloride (ACNU) for brainstem recurrent glioma.

    Saito R, Kanamori M, Sonoda Y, Yamashita Y, Nagamatsu K, Murata T, Mugikura S, Kumabe T, Wembacher-Schröder E, Thomson R, Tominaga T

    Neuro-oncology advances   2 巻 ( 1 ) 頁: vdaa033   2020年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/noajnl/vdaa033

    PubMed

    その他リンク: http://academic.oup.com/noa/article-pdf/2/1/vdaa033/33171642/vdaa033.pdf

  81. <i>TERT</i> promoter mutation associated with multifocal phenotype and poor prognosis in patients with <i>IDH</i> wild-type glioblastoma.

    Kikuchi Z, Shibahara I, Yamaki T, Yoshioka E, Shofuda T, Ohe R, Matsuda KI, Saito R, Kanamori M, Kanemura Y, Kumabe T, Tominaga T, Sonoda Y

    Neuro-oncology advances   2 巻 ( 1 ) 頁: vdaa114   2020年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/noajnl/vdaa114

    PubMed

    その他リンク: http://academic.oup.com/noa/article-pdf/2/1/vdaa114/35106481/vdaa114.pdf

  82. Cystic Glioblastoma Rupturing into the Ventricle.

    Sato Y, Saito R, Kanamori M, Tominaga T

    NMC case report journal   7 巻 ( 1 ) 頁: 39-41   2020年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2176/nmccrj.cr.2019-0043

    PubMed

  83. A multicenter randomized phase III study for newly diagnosed maximally resected glioblastoma comparing carmustine wafer implantation followed by chemoradiotherapy with temozolomide with chemoradiotherapy alone; Japan Clinical Oncology Group Study JCOG1703 (MACS study). 国際誌

    Kadota T, Saito R, Kumabe T, Mizusawa J, Katayama H, Sumi M, Igaki H, Kinoshita M, Komori T, Ichimura K, Narita Y, Nishikawa R

    Japanese journal of clinical oncology   49 巻 ( 12 ) 頁: 1172 - 1175   2019年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jjco/hyz169

    Web of Science

    PubMed

  84. 超選択的Wada testによる血管解剖と機能解剖のハイブリッド評価 査読有り

    大沢 伸一郎, 鈴木 匡子, 新妻 邦泰, 浮城 一司, 柿沼 一雄, 上利 大, 神 一敬, 斎藤 竜太, 金森 政之, 中里 信和, 冨永 悌二

    脳血管内治療   4 巻 ( Suppl. ) 頁: S383 - S383   2019年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(NPO)日本脳神経血管内治療学会  

  85. Coexistence of Intracranial Germ Cell Tumor with Growing Arteriovenous Fistula.

    Ishida T, Endo H, Saito R, Kanamori M, Sato K, Matsumoto Y, Endo T, Fujimura M, Tominaga T

    World neurosurgery   127 巻   頁: 126 - 130   2019年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.wneu.2019.04.015

    PubMed

  86. Phase I study of a brain penetrant mutant IDH1 inhibitor DS-1001b in patients with recurrent or progressive IDH1 mutant gliomas.

    Natsume Atsushi, Wakabayashi Toshihiko, Miyakita Yasuji, Narita Yoshitaka, Mineharu Yohei, Arakawa Yoshiki, Yamasaki Fumiyuki, Sugiyama Kazuhiko, Hata Nobuhiro, Muragaki Yoshihiro, Nishikawa Ryo, Shinojima Naoki, Kumabe Toshihiro, Saito Ryuta, Ito Kazumi, Tachibana Masaya, Kakurai Yasuyuki, Nishijima Soichiro, Tsubouchi Hiroshi

    JOURNAL OF CLINICAL ONCOLOGY   37 巻 ( 15 ) 頁: .   2019年5月

     詳細を見る

    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Web of Science

  87. 脳幹部神経膠腫診断におけるメチオニンPET検査の有用性

    齋藤 竜太, 金森 政之, 高浪 健太郎, 園田 順彦, 冨永 悌二

    Brain Tumor Pathology   36 巻 ( Suppl. ) 頁: 090 - 090   2019年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

  88. Coexistence of an intracranial germ cell tumor with a growing arteriovenous fistula: a case report. 査読有り

    Ishida T, Endo H, Saito R, Kanamori M, Sato K, Matsumoto Y, Endo T, Fujimura M, Tominaga T

    World Neurosurg     2019年4月

     詳細を見る

    記述言語:英語  

  89. Incidence of initial spinal metastasis in glioblastoma patients and the importance of spinal screening using MRI. 査読有り 国際誌

    Shibahara I, Saito R, Osada Y, Kanamori M, Sonoda Y, Kumabe T, Mugikura S, Watanabe M, Tominaga T

    Journal of neuro-oncology   141 巻 ( 2 ) 頁: 337 - 345   2019年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11060-018-03036-4

    PubMed

  90. Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors. 査読有り 国際誌

    Fukuoka K, Kanemura Y, Shofuda T, Fukushima S, Yamashita S, Narushima D, Kato M, Honda-Kitahara M, Ichikawa H, Kohno T, Sasaki A, Hirato J, Hirose T, Komori T, Satomi K, Yoshida A, Yamasaki K, Nakano Y, Takada A, Nakamura T, Takami H, Matsushita Y, Suzuki T, Nakamura H, Makino K, Sonoda Y, Saito R, Tominaga T, Matsusaka Y, Kobayashi K, Nagane M, Furuta T, Nakada M, Narita Y, Hirose Y, Ohba S, Wada A, Shimizu K, Kurozumi K, Date I, Fukai J, Miyairi Y, Kagawa N, Kawamura A, Yoshida M, Nishida N, Wataya T, Yamaoka M, Tsuyuguchi N, Uda T, Takahashi M, Nakano Y, Akai T, Izumoto S, Nonaka M, Yoshifuji K, Kodama Y, Mano M, Ozawa T, Ramaswamy V, Taylor MD, Ushijima T, Shibui S, Yamasaki M, Arai H, Sakamoto H, Nishikawa R, Ichimura K, Japan Pediatric Molecular Neuro-Oncology Group (JPMNG).

    Acta neuropathologica communications   6 巻 ( 1 ) 頁: 134 - 134   2018年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s40478-018-0630-1

    PubMed

  91. Development and evaluation of ultrasound-facilitated drug delivery device 査読有り

    Inoue Kenji, Sato Aya, Saito Ryuta, Jia Wenting, Okuno Saori, Ohashi Yuji, Kamada Kei, Yoshikawa Akira, Tominaga Teiji

    JAPANESE JOURNAL OF APPLIED PHYSICS   57 巻 ( 11 )   2018年11月

  92. DEVELOPMENT OF ULTRASOUND-FACILITATED DRUG DELIVERY DEVICE FOR LOCAL DRUG INFUSION AGAINST BRAIN TUMORS 査読有り

    Saito Ryuta, Sato Aya, Inoue Kenji, Jia Wenting, Okuno Saori, Ohashi Yuji, Kamada Kei, Yoshikawa Akira, Tominaga Teiji

    NEURO-ONCOLOGY   20 巻   頁: 88   2018年11月

     詳細を見る

  93. SMART (stroke-like migraine attacks after radiation therapy) syndrome responded to steroid pulse therapy: Report of a case and review of the literature. 査読有り 国際誌

    Jia W, Saito R, Kanamori M, Iwabuchi N, Iwasaki M, Tominaga T

    eNeurologicalSci   12 巻   頁: 1 - 4   2018年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.ensci.2018.05.003

    PubMed

  94. Indications for salvage surgery during treatment for intracranial germ cell tumors. 査読有り 国際誌

    Kanamori M, Kumabe T, Watanabe M, Chonan M, Saito R, Yamashita Y, Ogawa Y, Sonoda Y, Tominaga T

    Journal of neuro-oncology   138 巻 ( 3 ) 頁: 601 - 607   2018年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11060-018-2827-3

    PubMed

  95. [A Case of Ventriculoperitoneal Shunt Dysfunction in an Adult Secondary to Constipation]. 査読有り

    Nakamura L, Saito R, Kanamori M, Morita T, Tashiro R, Tominaga T

    No shinkei geka. Neurological surgery   46 巻 ( 5 ) 頁: 385 - 389   2018年5月

     詳細を見る

    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.11477/mf.1436203739

    PubMed

  96. Clinical Features of Precocious, Synchronous, and Metachronous Brain Metastases and the Role of Tumor Resection. 査読有り 国際誌

    Shibahara I, Kanamori M, Watanabe T, Utsunomiya A, Suzuki H, Saito R, Sonoda Y, Jokura H, Uenohara H, Tominaga T

    World neurosurgery   113 巻   頁: e1 - e9   2018年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.wneu.2017.10.145

    PubMed

  97. [Results for Treatment of Newly-Diagnosed Glioblastoma Using Carmustine Wafers(Gliadel<sup>®</sup>)]. 査読有り

    Kumabe T, Shibahara I, Saito R

    No shinkei geka. Neurological surgery   46 巻 ( 5 ) 頁: 367 - 376   2018年5月

     詳細を見る

    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.11477/mf.1436203736

    PubMed

  98. Rapid detection of mutation in isocitrate dehydrogenase 1 and 2 genes using mass spectrometry. 査読有り

    Kanamori M, Maekawa M, Shibahara I, Saito R, Chonan M, Shimada M, Sonoda Y, Kumabe T, Watanabe M, Mano N, Tominaga T

    Brain tumor pathology   35 巻 ( 2 ) 頁: 90 - 96   2018年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10014-018-0317-0

    PubMed

  99. Three case reports of radiation-induced glioblastoma after complete remission of acute lymphoblastic leukemia. 査読有り

    Kajitani T, Kanamori M, Saito R, Watanabe Y, Suzuki H, Watanabe M, Kure S, Tominaga T

    Brain tumor pathology   35 巻 ( 2 ) 頁: 114 - 122   2018年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10014-018-0316-1

    Scopus

    PubMed

  100. Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model. 査読有り 国際誌

    Haryu S, Saito R, Jia W, Shoji T, Mano Y, Sato A, Kanamori M, Sonoda Y, Sampetrean O, Saya H, Tominaga T

    Journal of neuro-oncology   136 巻 ( 1 ) 頁: 23 - 31   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11060-017-2621-7

    PubMed

  101. Fingolimod-associated PML with mild IRIS in MS: A clinicopathologic study. 査読有り 国際誌

    Nishiyama S, Misu T, Shishido-Hara Y, Nakamichi K, Saijo M, Takai Y, Takei K, Yamamoto N, Kuroda H, Saito R, Watanabe M, Tominaga T, Nakashima I, Fujihara K, Aoki M

    Neurology(R) neuroimmunology & neuroinflammation   5 巻 ( 1 ) 頁: e415   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1212/NXI.0000000000000415

    PubMed

  102. Glioblastoma in neurofibromatosis 1 patients without IDH1, BRAF V600E, and TERT promoter mutations. 査読有り

    Shibahara I, Sonoda Y, Suzuki H, Mayama A, Kanamori M, Saito R, Suzuki Y, Mashiyama S, Uenohara H, Watanabe M, Kumabe T, Tominaga T

    Brain tumor pathology   35 巻 ( 1 ) 頁: 10 - 18   2018年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10014-017-0302-z

    PubMed

  103. Opening the ventricle during surgery diminishes survival among patients with newly diagnosed glioblastoma treated with carmustine wafers: a multi-center retrospective study. 査読有り

    Sonoda Y, Shibahara I, Matsuda KI, Saito R, Kawataki T, Oda M, Sato Y, Sadahiro H, Nomura S, Sasajima T, Beppu T, Kanamori M, Sakurada K, Kumabe T, Tominaga T, Kinouchi H, Shimizu H, Ogasawara K, Suzuki M

    Journal of neuro-oncology   134 巻 ( 1 ) 頁: 83 - 88   2017年8月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s11060-017-2488-7

    Web of Science

    PubMed

  104. Distant recurrences limit the survival of patients with thalamic high-grade gliomas after successful resection. 査読有り

    Saito R, Kumabe T, Kanamori M, Sonoda Y, Tominaga T

    Neurosurgical review   40 巻 ( 3 ) 頁: 469 - 477   2017年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10143-016-0804-x

    Web of Science

    PubMed

  105. Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models. 査読有り

    Ogita S, Endo T, Sugiyama S, Saito R, Inoue T, Sumiyoshi A, Nonaka H, Kawashima R, Sonoda Y, Tominaga T

    Acta neurochirurgica   159 巻 ( 5 ) 頁: 939 - 946   2017年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00701-017-3123-2

    Web of Science

    PubMed

  106. Intraoperative Visualization of Subependymal Arteries at the Atrium Supplying the Descending Motor Pathway. 査読有り

    Hanihara M, Sato S, Shibahara I, Saito R, Kanamori M, Sonoda Y, Kinouchi H, Tominaga T, Kumabe T

    World neurosurgery   101 巻   頁: 296 - 303   2017年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.wneu.2017.02.022

    Web of Science

    PubMed

  107. 術中迅速診断へのmass spectrometryの応用

    金森 政之, 前川 正充, 柴原 一陽, 斎藤 竜太, 園田 順彦, 渡辺 みか, 冨永 悌二

    Brain Tumor Pathology   34 巻 ( Suppl. ) 頁: 105 - 105   2017年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

  108. Convection-enhanced Delivery of Therapeutics for Malignant Gliomas. 査読有り

    Saito R, Tominaga T

    Neurologia medico-chirurgica   57 巻 ( 1 ) 頁: 8 - 16   2017年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2176/nmc.ra.2016-0071

    Web of Science

    PubMed

  109. Extremely Late Recurrence 21 Years after Total Removal of Immature Teratoma: A Case Report and Literature Review. 査読有り

    Mano Y, Kanamori M, Kumabe T, Saito R, Watanabe M, Sonoda Y, Tominaga T

    Neurologia medico-chirurgica   57 巻 ( 1 ) 頁: 51 - 56   2017年1月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2176/nmc.cr.2016-0241

    Web of Science

    PubMed

▼全件表示

MISC 21

  1. Medical Management of a Mural Thrombus Inducing Repeated Ischemic Strokes in a Patient with Congenital Afibrinogenemia.

    Nishihori M, Araki Y, Suzuki N, Tamura S, Hattori M, Izumi T, Goto S, Yokoyama K, Uda K, Matsushita T, Saito R  

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association31 巻 ( 7 ) 頁: 106526   2022年7月

     詳細を見る

    記述言語:英語   出版者・発行元:Journal of Stroke and Cerebrovascular Diseases  

    Objectives: Congenital afibrinogenemia is an autosomal recessive inherited disorder that can cause thrombotic as well as hemorrhagic events. We describe a case of repeated mild ischemic strokes due to a mural thrombus in the carotid artery and our medical treatment. Case description: A 49-year-old woman with congenital afibrinogenemia developed two minor ischemic strokes in two months. Clinical images revealed scattered fresh infarcts in the right middle cerebral artery region and mild cervical carotid artery stenosis. The risk for surgical treatment was considered to be extraordinarily high. The patient was treated with 100 mg/day of aspirin and 3 g fibrinogen infusion every two weeks. After the one-year course of medication, the mural thrombus gradually decreased, and there were no bleeding or ischemic stroke events. Conclusion: This case report highlights the successful treatment of an ischemic stroke in a patient with a congenital afibrinogenemia with an antiplatelet agent and fibrinogen replacement. There are no guidelines for managing ischemic stroke in patients with congenital afibrinogenemia, and further studies are needed.

    DOI: 10.1016/j.jstrokecerebrovasdis.2022.106526

    Scopus

    PubMed

  2. Atypical radiographic case of arachnoid web without scalpel sign.

    Nagashima Y, Nishimura Y, Ito H, Oyama T, Nishii T, Gonda T, Kato H, Saito R  

    Surgical neurology international13 巻   頁: 108   2022年

     詳細を見る

    記述言語:英語   出版者・発行元:Surgical Neurology International  

    Background: Spinal arachnoid webs (SAW) occur when abnormally thickened bands of arachnoid membranes commonly located dorsal to the thoracic spine cause blockage of normal cerebrospinal fluid (CSF) flow, resulting in focal cord compression and myelopathy. The pathognomonic MR finding for SAW is the "positive scalpel sign"comprised of an enlarged dorsal CSF space with a normal ventral subarachnoid space. The main differential diagnostic consideration for SAW is idiopathic spinal cord herniation (ISCH); however, for ISCH, MR studies classically demonstrate ventral displacement of the spinal cord through an anterior dural defect. Here, we describe a 60-year-old female with an atypical SAW at the T3-T4 level (i.e., the preoperative MR failed to demonstrate the "positive scalpel sign"). Nevertheless, at surgery, intraoperative ultrasonography confirmed that SAW was present and was decompressed/marsupialized/removed. Case Description: A 60-year-old female presented with sensory impairment to both lower extremities. The thoracic MR images showed an enlarged dorsal CSF space at the T3-T4 level but without the "scalpel sign"suggesting "interruption"of CSF flow by thickened bands of focal dorsal arachnoidal tissues. Although the initial preoperative diagnosis was ISCH, intraoperative ultrasound (IOUS) confirmed the presence of a thickened arachnoid band, confirming the diagnosis of a SAW that was appropriately decompressed/resected. Conclusion: Correctly, establishing the preoperative diagnosis of a SAW based on MR imaging may sometimes be difficult as the typical "scalpel sign"may not be present in all patients. Notably, in cases like this one, IOUS may critically confirm the diagnosis of SAW thus leading to appropriate SAW decompression/removal.

    DOI: 10.25259/SNI_179_2022

    Scopus

    PubMed

  3. Two cases of solitary fibrous tumor/hemangiopericytoma with different clinical features according to the World Health Organization classification: case report and review of the literature.

    Nishii T, Nagashima Y, Nishimura Y, Ito H, Oyama T, Matsuo M, Sakakibara A, Shimada S, Saito R  

    Journal of spine surgery (Hong Kong)7 巻 ( 4 ) 頁: 532 - 539   2021年12月

     詳細を見る

    記述言語:英語   出版者・発行元:Journal of Spine Surgery  

    Solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) have been classified as one entity by the World Health Organization in 2016 due to gene fusion between NAB2 and STAT6. In the Central Nervous System (CNS), a hypocellular, collagenized tumor with a classic SFT phenotype is considered grade I, whereas more densely cellular tumors mostly corresponding to the HPC phenotype are classified as grade II or III (anaplastic) depending in mitotic count (<5 vs. >5 mitoses per 10 high-power fields). Herein, we report two cases of targeted SFT/HPC in which pathological differences and WHO grading affect clinical features. A 75-year-old woman presented with headache and had an intradural extramedullary tumor at the C1 to C2 level. The tumor was well-circumscribed and attached only to the dura mater. It was totally removed and diagnosed SFT/HPC grade I. In contrast, a 68-year-old woman presented with numbness in the right upper limb and had an intradural extramedullary tumor at the medulla to C3 levels The tumor was irregularly marginated and strongly adherent to the spinal cord and involved the vertebral artery. It was sub totally removed and diagnosed SFT/HPC grade II. To the best of our knowledge, there are only 12 cases of SFT/HPC at the craniocervical junction, including the present two cases, of which four that were adherent to the spinal cord or involved the vertebral artery were grade II or III. Although the location of the tumor was almost the same, there were significant differences in the intraoperative findings according to the WHO grading.

    DOI: 10.21037/jss-21-83

    Scopus

    PubMed

  4. Management of Asymptomatic Vertebral Artery Injury Caused by a Cervical Pedicle Screw Malposition: Two Case Reports.

    Otsuka T, Izumi T, Nishihori M, Tsukada T, Araki Y, Yokoyama K, Uda K, Goto S, Ikezawa M, Kato N, Nakano M, Saito R  

    NMC case report journal8 巻 ( 1 ) 頁: 713 - 717   2021年

     詳細を見る

    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/nmccrj.cr.2021-0062

    PubMed

    CiNii Research

  5. Postoperative Cervicothoracic Kyphosis Following Infantile Intramedullary Tumor Resection Accelerates Neurological Deterioration.

    Gonda T, Nagashima Y, Nishimura Y, Ito H, Nisii T, Oyama T, Hara M, Saito R  

    NMC case report journal8 巻 ( 1 ) 頁: 705 - 711   2021年

     詳細を見る

    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/nmccrj.cr.2021-0086

    PubMed

    CiNii Research

  6. 高齢者脳実質内腫瘍における非痙攣性てんかん重積

    金森政之, 大沢伸一郎, 下田由輝, 斎藤竜太, 冨永悌二  

    日本老年脳神経外科学会プログラム・抄録集34th (CD-ROM) 巻   2021年

     詳細を見る

  7. 頭蓋内胚腫治療後にてんかんを発症した症例群の検討

    下田由輝, 金森政之, 大沢伸一郎, 齋藤竜太, 園田順彦, 隈部俊宏, 中里信和, 冨永悌二  

    てんかん研究39 巻 ( 2 )   2021年

     詳細を見る

  8. Survival Benefit of Supratotal Resection in a Long-term Survivor of <i>IDH</i>-wildtype Glioblastoma: A Case Report and Literature Review.

    Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Shimizu H, Natsume A, Wakabayashi T, Saito R  

    NMC case report journal8 巻 ( 1 ) 頁: 747 - 753   2021年

     詳細を見る

    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/nmccrj.cr.2021-0120

    PubMed

    CiNii Research

  9. 頭蓋内胚腫治療後にてんかんを発症した症例群の検討

    下田由輝, 金森政之, 大沢伸一郎, 大沢伸一郎, 齋藤竜太, 園田順彦, 隈部俊宏, 中里信和, 冨永悌二  

    日本てんかん外科学会プログラム・抄録集44th 巻   2020年

     詳細を見る

  10. ULTRASOUND-FACILITATED DRUG DELIVERY DEVICE FOR LOCAL DRUG INFUSION AGAINST BRAIN TUMORS

    Ryuta Saito, Wenting Jia, Aya Sato, Kenji Inoue, Saori Okuno, Yuji Ohashi, Kei Kamada, Akira Yoshikawa, Teiji Tominaga  

    NEURO-ONCOLOGY21 巻   頁: 278 - 278   2019年11月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

    Web of Science

  11. 超選択的Wada testによる血管解剖と機能解剖のハイブリッド評価

    大沢 伸一郎, 鈴木 匡子, 新妻 邦泰, 浮城 一司, 柿沼 一雄, 上利 大, 神 一敬, 斎藤 竜太, 金森 政之, 中里 信和, 冨永 悌二  

    脳血管内治療4 巻 ( Suppl. ) 頁: S383 - S383   2019年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(NPO)日本脳神経血管内治療学会  

  12. Phase I study of a brain penetrant mutant IDH1 inhibitor DS-1001b in patients with recurrent or progressive IDH1 mutant gliomas.

    Atsushi Natsume, Toshihiko Wakabayashi, Yasuji Miyakita, Yoshitaka Narita, Yohei Mineharu, Yoshiki Arakawa, Fumiyuki Yamasaki, Kazuhiko Sugiyama, Nobuhiro Hata, Yoshihiro Muragaki, Ryo Nishikawa, Naoki Shinojima, Toshihiro Kumabe, Ryuta Saito, Kazumi Ito, Masaya Tachibana, Yasuyuki Kakurai, Soichiro Nishijima, Hiroshi Tsubouchi  

    JOURNAL OF CLINICAL ONCOLOGY37 巻 ( 15 )   2019年5月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER SOC CLINICAL ONCOLOGY  

    DOI: 10.1200/JCO.2019.37.15_suppl.2004

    Web of Science

  13. 急性リンパ性白血病完全緩解後に発生した放射線誘発性膠芽腫の3例

    金森 政之, 斎藤 竜太, 梶谷 卓未, 渡辺 みか, 鈴木 博義, 渡辺 祐子, 呉 繁夫, 冨永 悌二  

    Brain Tumor Pathology35 巻 ( Suppl. ) 頁: 165 - 165   2018年9月

     詳細を見る

    記述言語:日本語   出版者・発行元:日本脳腫瘍病理学会  

  14. Fingolimod-Associated PML with Mild Immune Reconstitution Inflammatory Syndrome in Multiple Sclerosis

    Shuhei Nishiyama, Tatsuro Misu, Yukiko Shishido-Hara, Kazuo Nakamichi, Masayuki Saijo, Yoshiki Takai, Kentarou Takei, Naoki Yamamoto, Hiroshi Kuroda, Ryuta Saito, Mika Watanabe, Teiji Tominaga, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki  

    MULTIPLE SCLEROSIS JOURNAL24 巻 ( 3 ) 頁: 381 - 382   2018年3月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

    Web of Science

  15. 小児血液・腫瘍入院患者の傾向と、診断まで時間のかかった症例の検討

    新妻 秀剛, 鈴木 資, 片山 紗乙莉, 渡辺 祐子, 入江 正寛, 力石 健, 笹原 洋二, 呉 繁夫, 齋藤 竜太, 金森 政之, 風間 理郎, 綿貫 宗則, 保坂 正美  

    日本小児科学会雑誌122 巻 ( 1 ) 頁: 93 - 93   2018年1月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

  16. ACNU AS THE BEST NITROSOUREA FOR LOCAL CONVECTION-ENHANCED DELIVERY: REPORT ON PHARMACOKINETICS

    Ryuta Saito, Jia Wenting, Aya Sato, Saori Okuno, Taigen Nakamura, Masashi Chonan, Rong Zhang, Masayuki Kanamori, Teiji Tominaga  

    NEURO-ONCOLOGY19 巻   頁: 90 - 90   2017年11月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

    Web of Science

  17. LONG-TERM OUTCOME OF CRANIOSPINAL IRRADIATION FOR RECURRENT GERMINOMA

    Masayuki Kanamori, Ryuta Saito, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga  

    NEURO-ONCOLOGY19 巻   頁: 222 - 222   2017年11月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

    Web of Science

  18. LIMITATION OF RADICAL RESECTION OF GLIOBLASTOMA INFILTRATING FROM AMYGDALA TO GLOBUS PALLIDUS: EFFECTIVENESS OF CARMUSTINE WAFERS FOR RESIDUAL TUMOR CONTROL

    Toshihiro Kumabe, Mitsuto Hanihara, Ichiyo Shibahara, Sumito Sato, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Teiji Tominaga  

    NEURO-ONCOLOGY19 巻   頁: 265 - 265   2017年11月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS INC  

    Web of Science

  19. 心因性嘔吐が疑われた膠芽腫の1例 脳腫瘍を見逃さないために

    相原 悠, 渡辺 祐子, 鈴木 佐和子, 鈴木 資, 入江 正寛, 新妻 秀剛, 力石 健, 笹原 洋二, 呉 繁夫, 齋藤 竜太, 金森 政之, 富永 悌二  

    日本小児科学会雑誌121 巻 ( 6 ) 頁: 1124 - 1124   2017年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(公社)日本小児科学会  

  20. 東北大学病院におけるSJMB96による治療経験

    渡辺 祐子, 新妻 秀剛, 入江 正寛, 力石 健, 笹原 洋二, 渡辺 みか, 齋藤 竜太, 金森 政之, 園田 順彦, 冨永 悌二, 呉 繁夫  

    小児の脳神経42 巻 ( 2 ) 頁: 120 - 120   2017年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本小児神経外科学会  

  21. Hypoxia-like Tissue Injury and Glial Response Contribute to the Development of Balo's Concentric Demyelination

    Y. Takai, T. Misu, S. Nishiyama, H. Ono, H. Kuroda, I. Nakashima, R. Saito, M. Kanamori, S. Mugikura, M. Watanabe, M. Aoki, K. Fujihara  

    MULTIPLE SCLEROSIS JOURNAL23 巻 ( 2 ) 頁: 349 - 350   2017年2月

     詳細を見る

    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SAGE PUBLICATIONS LTD  

    Web of Science

▼全件表示

講演・口頭発表等 32

  1. 悪性グリオーマの最新治療とprecision medicineの未来

    齋藤竜太

    第42回日本脳神経外科コングレス  2022年5月13日  日本脳神経外科コングレス

     詳細を見る

    開催年月日: 2022年5月

    記述言語:英語   会議種別:シンポジウム・ワークショップ パネル(指名)  

  2. 摘出度を適格規準として術中ランダム化を行う膠芽腫に対する比較臨床試験

    齋藤竜太、木下 学、山崎文之、角 美奈子、井垣 浩、渋谷 誠、佐々木 惇、小森隆司、荒川芳輝、成田善孝、西川亮、関野雄太、佐々木啓太、隈部俊宏

    第39回日本脳腫瘍学会学術集会  2021年12月5日  日本脳腫瘍学会

     詳細を見る

    開催年月日: 2021年12月

    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(公募)  

    開催地:兵庫  

  3. 薬剤局所投与による脳腫瘍新規治療法の開発 招待有り

    齋藤竜太

    第1回東海北陸脳腫瘍セミナー  2021年11月29日 

     詳細を見る

    開催年月日: 2021年11月

    記述言語:日本語   会議種別:口頭発表(招待・特別)  

  4. 脳腫瘍治療成績向上に向けた取り組みの現状

    齋藤竜太

    第24回日本臨床脳神経外科学会学術集会  2021年11月12日  日本臨床脳神経外科学会

     詳細を見る

    開催年月日: 2021年11月

    記述言語:日本語   会議種別:口頭発表(招待・特別)  

    開催地:沖縄  

  5. Visualization of drug delivery in local convection-enhanced delivery against brain tumors 招待有り

    2021年10月30日 

     詳細を見る

    開催年月日: 2021年10月

    記述言語:英語  

  6. 脳腫瘍治療成績向上を目指して:摘出術を中心に 招待有り

    齋藤竜太

    第80回日本脳神経外科学会学術集会  2021年10月29日  日本脳神経外科学会

     詳細を見る

    開催年月日: 2021年10月

    記述言語:日本語   会議種別:口頭発表(招待・特別)  

    開催地:横浜  

  7. 脳幹グリオーマに対するConvection-enhanced deliveryを用いた局所化学療法

    齋藤竜太

    第80回日本脳神経外科学会学術集会  2021年10月27日  日本脳神経外科学会

     詳細を見る

    開催年月日: 2021年10月

    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(指名)  

    開催地:横浜  

  8. グリオーマ治療の現状と近未来 招待有り

    齋藤竜太

    第100回日本脳神経外科学会中部支部学術集会  2021年9月18日  日本脳神経外科学会中部支部

     詳細を見る

    開催年月日: 2021年9月

    記述言語:日本語   会議種別:口頭発表(招待・特別)  

    開催地:名古屋  

  9. 画像誘導下脳腫瘍局所治療

    齋藤竜太

    2021年5月15日  日本脳神経外科コングレス

     詳細を見る

    開催年月日: 2021年5月

    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(指名)  

    開催地:大阪  

  10. 脳腫瘍に対する局所化学療法 招待有り

    齋藤竜太

    第30回脳神経外科手術と機器学会  2021年4月24日  日本脳神経外科手術と機器学会

     詳細を見る

    開催年月日: 2021年4月

    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(指名)  

    開催地:札幌  

  11. 脳腫瘍の局所治療 招待有り

    齋藤竜太

    第99回日本脳神経外科学会中部支部学術集会  2021年4月3日  日本脳神経外科学会中部支部

     詳細を見る

    開催年月日: 2021年4月

    記述言語:日本語   会議種別:口頭発表(招待・特別)  

    開催地:金沢  

  12. 悪性神経膠腫治療成績向上を目指して 招待有り

    齋藤竜太

    ニューロオンコロジーセントラル  2021年3月27日  NeuroOncology Centeral/中外製薬

     詳細を見る

    開催年月日: 2021年3月

    記述言語:日本語   会議種別:口頭発表(招待・特別)  

    開催地:名古屋  

  13. A Pediatric Case of Left Frontal Hemorrhagic Tumor Radiographically Diagnosed as Leukoencephalopathy with Calcification and Cysts.

    齋藤竜太, 金森政之, 植松貢, 渡辺みか, 冨永悌二

    ICN/BTP2018 (第36回日本脳腫瘍病理学会)  2018年  日本脳腫瘍病理学会

  14. 脳腫瘍関連てんかんに対するフィコンパ投与経験

    齋藤竜太

    Epilepsy Summit in Sendai  2018年 

  15. 脳腫瘍に対するニトロソウレア剤局所投与:ACNUの有用性に関する基礎的研究

    齋藤竜太, Jia Wenting, 佐藤綾耶, 奥野さおり, 中村太源, 長南雅志, Rong Zhang, Xiaoliang Yang, 金森政之, 冨永悌二

    第18回日本分子脳神経外科学会  2017年  日本分子脳神経外科学会

  16. 神経膠腫症例における症候性脳梗塞

    齋藤竜太, 金森政之, 長南雅志, 園田順彦, 隈部俊宏, 冨永悌二

    第43回日本脳卒中学会学術集会  2018年  日本脳卒中学会

  17. 神経膠腫に対する治療戦略 -臨床と研究から-

    齋藤竜太

    岩手県立病院医学会脳神経外科分科会  2018年 

  18. 東北大学脳神経外科における悪性神経膠腫に対するベバシズマブ使用の実際

    齋藤竜太, 金森政之, 長南雅志, 園田順彦, 冨永悌二

    東北地方会  2017年  日本脳神経外科学会

  19. 悪性神経膠腫に対する局所化学療法

    齋藤竜太, 金森政之, 園田順彦, 隈部俊宏, 冨永悌二

    第37回日本脳神経外科コングレス  2017年  日本脳神経外科学会

  20. 悪性神経膠腫における血栓塞栓症

    齋藤竜太

    東北脳腫瘍研究会  2018年 

  21. 小児第4 脳室上衣腫に対する治療戦略

    齋藤竜太, 金森政之, 園田順彦, 冨永悌二

    第23回日本脳腫瘍の外科学会  2018年  日本脳腫瘍の外科学会

  22. 小児びまん性橋神経膠腫に対するConvection-enhanced deliveryを用いた塩酸ニムスチン局所投与:医師主導治験

    齋藤竜太, 金森政之, 佐藤綾耶, 奥野さおり, 冨永悌二

    第46回日本小児神経外科学会  2018年  日本小児神経外科学会

  23. 初回再発悪性神経膠腫に対する摘出術後塩酸ニムスチンconvection enhanced delivery 投与とテモゾロミド内服?Phase I/II臨床試験?.

    齋藤竜太

    第32回日本脳腫瘍学会学術集会  日本脳腫瘍学会

  24. Venous thromboembolism in patients with malignant brain tumor: 〜management strategy to avoid mortality〜

    齋藤竜太

    第39回日本血栓止血学会学術集会  2017年  日本血栓止血学会

  25. Use of Bevacizumab against malignant glioma cases at Tohoku University Hospital: Initial experience with 100 cases

    齋藤竜太, 長南雅志, 園田順彦, 冨永悌二

    Asian Society for Neuro-Oncology  2017年 

  26. Phase I Trial of a Convection-enhanced Delivery of Nimustine Hydrochloride (ACNU) for Patients With Brainstem Recurrent Glioma

    Ryuta Saito, Yukihiko Sonoda, Masayuki Kanamori, Yoji Yamashita, Kenichi Nagamatsu, Toshihiro Kumabe, Teiji Tominaga

    Society for Neuro-oncology  2017年 

  27. Convection-enhanced deliveryによる脳幹腫瘍の治療:医師主導治験に向けて

    齋藤竜太, 金森政之, 園田順彦, 山下洋二, 麦倉俊司, 隈部俊宏, 冨永悌二

    日本脳神経外科学会第76回学術総会  2017年  日本脳神経外科学会

  28. Convection-enhanced deliveryによる脳幹腫瘍の治療

    齋藤竜太, 金森政之, 園田順彦, 山下洋二, 麦倉俊司, 隈部俊宏, 冨永悌二

    第22回日本脳腫瘍の外科学会  2017年  日本脳腫瘍の外科学会

  29. Convection-enhanced deliveryによる局所化学療法開発の現状

    齋藤竜太, 金森政之, 園田順彦, 麦倉俊司, 隈部俊宏, 冨永悌二

    第35回日本脳腫瘍学会学術集会  2017年  日本脳腫瘍学会

  30. Convection-enhanced delivery of Nimustine Hydrochroride against brainstem gliomas.

    齋藤竜太, 金森政之, 園田順彦, 隈部俊宏, 冨永悌二

    22th International Conference on Brain Tumor Research and Therapy  2018年 

  31. Convection-enhanced delivery of nimustine hydrochloride for malignant glioma.

    齋藤竜太, 冨永悌二

    The Fourth International MASSIN Congress  Madjid Samii Congress of International Neurosurgeons

  32. ACNU as the best nitrosourea for local convection-enhanced delivery: report on pharmacokinetics

    齋藤竜太, ジャウェンティン, 佐藤綾耶, 奥野さおり, 中村太源, 冨永悌二

    Society for Neuro-oncology  2017年 

▼全件表示

科研費 10

  1. 非侵襲的シミュレーションを可能とするコネクトーム基盤型機能外科手術の開発研究

    研究課題/研究課題番号:22H03184  2022年4月 - 2027年3月

    科学研究費助成事業  基盤研究(B)

    前澤 聡, Bagarinao E., 臼井 直敬, 齋藤 竜太, 藤原 幸一, 坪井 崇, 夏目 淳

      詳細を見る

    担当区分:研究分担者 

    本研究の概要は、定位的機能外科手術によるニューロモデュレーションがパーキンソン病、本態性振戦で有効性が認知され、更にてんかんや精神神経疾患、認知症への適応拡大に向けて期待されている背景において、治療の標的部位選択やモダリティの最適化への非侵襲的術前評価アルゴリズムを、特に安静時機能的MRIに代表される脳神経回路(コネクトーム)解析を利用して開発し、この様な技術に基づいたコネクトーム基盤型定位機能外科手術を確立を目指す研究である。

  2. 超音波併用脳内局所薬剤送達システムの臨床応用に向けた研究

    研究課題/研究課題番号:21H03039  2021年4月 - 2024年3月

    科学研究費助成事業  基盤研究(B)

    齋藤 竜太, 冨永 悌二, 大橋 雄二, 金森 政之

      詳細を見る

    担当区分:研究代表者 

    配分額:17550000円 ( 直接経費:13500000円 、 間接経費:4050000円 )

    これまで脳実質内局所広範囲に高濃度薬剤送達を可能とする新規薬物送達法Convectionenhanced delivery(CED)を用いた中枢神経系疾患の新規治療法の開発を進め、2018年より小児脳幹部神経膠腫を対象とした化学療法剤局所投与の医師主導治験を開始した。さらに超音波併用薬剤投与技術を確立し、CEDを超える広範囲薬剤投与を可能とした。本技術は、脳内薬剤注入局所での超音波併用を可能とする点で独自の技術であり、複雑な組織構築へも均一な薬剤分布を可能とする可能性がある。特に現在、治療開発を進めている脳腫瘍モデルへの治療効果解析を進め、臨床応用に向けた基盤を構築し、臨床応用へ繋げたい。

  3. 超音波併用脳内局所広範囲薬剤投与法を用いた画期的なアルツハイマー病新規治療法開発

    研究課題/研究課題番号:20K21641  2020年7月 - 2023年3月

    科学研究費助成事業  挑戦的研究(萌芽)

    齋藤 竜太

      詳細を見る

    担当区分:研究代表者 

    配分額:6240000円 ( 直接経費:4800000円 、 間接経費:1440000円 )

    アルツハイマー病に関して近年、精力的に研究が進められており、アミロイド蛋白の蓄積を可視化する研究が進められている。この中で、早期におけるアミロイド蛋白の蓄積は全般性ではなく、脳のある部位に特に蓄積が多くなる傾向があることが判明しており、アミロイド蓄積部位の局所治療が功を奏する可能性が示唆される。これまでに脳内広範囲薬剤送達技術によりアミロイド蓄積を低減できる可能性を確認しており、本研究では脳局所のアミロイド沈着を解除する新規治療法の開発を行う。

  4. 浸潤病変の局所制御と術後機能温存を両立する微弱衝撃波パルスジェットメスの開発

    研究課題/研究課題番号:18H04157  2018年4月 - 2021年3月

    科学研究費助成事業  基盤研究(A)

    中川 敦寛, 冨永 悌二, 遠藤 俊毅, 中西 史, 大沢 伸一郎, 齋藤 竜太, 山下 慎一, 唐澤 秀明, 辻田 哲平, 荒船 龍彦, 大谷 清伸, 近野 敦, 八木橋 真央, 森田 隆弘, 西嶌 泰生

      詳細を見る

    担当区分:研究分担者 

    本研究の目的は、申請者らが原理開発から臨床研究まで開発を進めたパルスジェットメスに微弱衝撃波を印加することで、内視鏡下に脳内浸潤病変境界部への薬剤深達が得られることを明らかにすることである。本研究では、1. 浸潤病変部の物性値を物性工学的検討で測定、2. 微弱衝撃波印加後のパルスジェットの流体動態と組織内深達効果を流体工学、模擬モデルを用いた検討、組織学的検討で臨床的に有用性をもたらすことができる条件を同定、3.模擬モデルおよび動物モデルで内視鏡下手術用パルスジェットメスに微弱衝撃波を印加、照射し、従来の切開、剥離に加え局所病変制御効果を評価した。
    本研究で得られた知見から、水ジェットの組織選択性に加えて、パルスジェットに微弱衝撃波を印加することで、液体を意図した範囲で拡散させられる可能性が示唆された。
    衝撃波による流体動態修飾が可能である点は液体制御の産業応用の観点だけでなく衝撃波工学の観点から学術的意義がある。パルスジェットメスの特徴である細血管・神経の温存下の切開、剥離に加えて脳損傷を発生させない微弱衝撃波を照射し、手術摘出腔周囲に薬剤を浸潤する機能を付加することで、最大限の局所病変制御と機能温存の両立が期待でき、脳を含めた悪性疾患の浸潤病変に対する新たな治療戦略の提供、機器の事業化につながり得る点で意義がある。

  5. 浸潤病変の局所制御と術後機能温存を両立する微弱衝撃波パルスジェットメスの開発

    2018年4月 - 2021年3月

    文部科学省  科学研究費助成事業 基盤研究(A) 

    中川 敦寛

      詳細を見る

    資金種別:競争的資金

  6. 希少・難治小児脳幹部神経膠腫に対する塩酸ニムスチン局所投薬による新規治療法開発:多施設共同医師主導治験

    2017年4月 - 2020年3月

    日本医療研究開発機構(AMED)  臨床研究・治験推進研究事業 

    冨永 悌二

      詳細を見る

    資金種別:競争的資金

  7. 脳内広範囲薬剤送達技術を用いたChemicalSurgery確立に向けた基礎研究

    研究課題/研究課題番号:17H04299  2017年4月 - 2020年3月

    科学研究費助成事業  基盤研究(B)

    齋藤 竜太, 冨永 悌二, 宇留野 晃

      詳細を見る

    担当区分:研究代表者 

    配分額:17290000円 ( 直接経費:13300000円 、 間接経費:3990000円 )

    脳内広範囲薬剤送達技術の基礎研究として(1)投与薬剤の代謝経路解明:RI標識した塩酸ニムスチンによる薬物動態、質量分析による薬剤の局所分布可視化、(2)生体内での薬剤動態の可視化:MRI撮像技術の開発、(3)最適投薬剤形の選択に関する知見の総括・ACNU剤形の決定:剤形による投与後局所での薬剤拡散・薬剤クリアランスの違いを総括し、ACNUの剤形を確定した、(4)新規超音波送達システムを用いる際の超音波が脳に与える影響の解明:新規超音波システムの音場特性評価として水中における超音波の伝搬を測定しデータの集積を実施した。
    CEDは拡散を利用した従来の脳内局所投与とは異なり、陽圧をかけ、脳構造に機械的な損傷を加えることなく脳組織間隙に広範で高濃度の薬剤分布が得られる新規薬剤投与法である。薬剤の脳内分布は注入量と速度によりある程度制御可能で、薬剤による全身合併症はほとんど無視できるレベルにとどまるとされている。近年の分子生物学の発展により、遺伝子治療を初めとする核酸医薬、分子標的薬の投与にも局所投与は必要になると考えられ、病変局所に広く投薬できる手法の開発は新たな医療開発の可能性を秘めている。特に血液脳関門による薬剤送達困難のため、アンメットメディカルニーズが高い中枢神経疾患の治療においては重要な分野となっている。

  8. 脳内広範囲薬剤送達技術を用いたChemicalSurgery確立に向けた基礎研究

    2017年4月 - 2020年3月

    文部科学省  科学研究費助成事業 基盤研究(B) 

    齋藤 竜太

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

  9. 脳内広範囲薬剤送達 システムの開発- 塩酸ニムスチン局所投与による脳腫瘍治療法-

    2016年4月 - 2017年3月

    文部科学省  橋渡し研究加速ネットワークプログラム研究開発施設共用等促進費補助金 シーズB 

    冨永 悌二

      詳細を見る

    資金種別:競争的資金

  10. 幹細胞分化誘導薬を用いたCED法による膠芽腫新規治療法の開発

    2014年 - 2017年

    文部科学省  科学研究費助成事業 基盤研究(C) 

    園田 順彦

      詳細を見る

    資金種別:競争的資金

▼全件表示

 

担当経験のある科目 (本学) 2

  1. 医学入門

    2021

     詳細を見る

    医学部1年生に対して
    Human BiologyのSencesを担当した

  2. ポリクリ1

    2020

     詳細を見る

    ポリクリ1で実習に来る全てのグループに対してオリエンテーション、総括を行った。

担当経験のある科目 (本学以外) 1

  1. 脳腫瘍

    2021年9月 名城大学)

     詳細を見る

    科目区分:学部専門科目 

 

社会貢献活動 2

  1. 日本脳神経外科学会中部支部会市民公開講座

    役割:司会

    日本脳神経外科学会中部支部会  2022年9月

  2. ストップ!NO卒中プロジェクト 支部講演会in愛知

    役割:司会

    公益社団法人日本脳卒中協会/ファイザー株式会社  2021年11月

学術貢献活動 1

  1. 日本脳神経外科学会中部支部会

    役割:企画立案・運営等

    日本脳神経外科学会中部支部会  2022年9月

     詳細を見る

    種別:学会・研究会等