Updated on 2022/05/23

写真a

 
SAITO Ryuta
 
Organization
Graduate School of Medicine Program in Integrated Medicine Clinical Neurosciences Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Professor

Degree 1

  1. 博士(医学) ( 2004.3   東北大学 ) 

Research Interests 5

  1. 集学的治療

  2. 脳腫瘍治療に向けたトランスレーショナルリサーチ

  3. 脳腫瘍免疫治療の開発

  4. surgical treatment for brain tumor

  5. convection enhanced delivery

Research Areas 2

  1. Life Science / Neurosurgery

  2. Life Science / Neurosurgery  / brain tumor

Research History 12

  1. 名古屋大学脳神経外科

    2020.12

      More details

    Country:Japan

  2. Tohoku University   Graduate School of Medicine   Lecturer

    2018

  3. 東北大学脳神経外科

    2008.9 - 2020.12

      More details

    Country:Japan

  4. Tohoku University   Graduate School of Medicine   Assistant Professor

    2008 - 2017

  5. さいたま赤十字病院脳神経外科

    2007.6 - 2008.8

      More details

    Country:Japan

  6. 仙台医療センター脳神経外科

    2007.4 - 2007.5

      More details

    Country:Japan

  7. 岩手県立中央病院脳神経外科

    2006.10 - 2007.3

      More details

    Country:Japan

  8. 広南病院脳神経外科

    2006.1 - 2006.9

      More details

    Country:Japan

  9. 東北大学脳神経外科

    2005.4 - 2005.12

      More details

    Country:Japan

  10. 宮城県立がんセンター

    2004.10 - 2005.3

      More details

    Country:Japan

  11. Department of Neurological Surgery, University of California San Francisco

    2002.9 - 2004.9

      More details

    Country:United States

  12. Department of Neurosurgery, Tohoku University

    1998.5 - 2000.4

      More details

    Country:Japan

▼display all

Education 3

  1. Tohoku University   Department of Neurosurgery

    2000.4 - 2004.3

      More details

    Country: Japan

  2. Tohoku University   Faculty of Medicine

    - 1998.3

      More details

    Country: Japan

  3. Tohoku University   Faculty of Medicine

    - 1998.3

      More details

    Country: Japan

Professional Memberships 23

  1. 日本脳神経外科コングレス   理事・運営委員

    2000

  2. 日本脳神経外科学会   理事・中部支部長

    1998

  3. American Society of Clinical Oncology

    2022.4

  4. 愛知県脳卒中対策推進委員会   委員長

    2022.4

  5. 愛知県脳卒中協会   副会長

    2021

  6. 脳神経外科手術と機器学会   理事

    2000.12

  7. Society for Neurooncology

  8. 日本脳卒中の外科学会   評議員

  9. 日本脳卒中学会

  10. 日本小児脳神経外科学会

  11. 日本神経内視鏡学会

  12. 日本癌学会

  13. 日本がん治療学会

  14. 日本脳腫瘍病理学会

  15. 日本脳腫瘍の外科学会

  16. 日本脳腫瘍学会

  17. The Japan Neurosurgical Society

  18. THE JAPAN SOCIETY OF BRAIN TUMOR PATHOLOGY

  19. 日本脳腫瘍の外科学会

  20. THE JAPAN STROKE SOCIETY

  21. THE JAPANESE SOCIETY ON SURGERY FOR CEREBRAL STROKE

  22. 日本小児脳神経外科学会

  23. 日本脳腫瘍病理学会   理事・事務局長

▼display all

Committee Memberships 1

  1. 名古屋大学脳とこころの研究センター   副センター長  

    2022.4   

 

Papers 72

  1. H3K27M and <i>TERT</i> promoter mutations are poor prognostic factors in surgical cases of adult thalamic high-grade glioma.

    Osada Y, Saito R, Shibahara I, Sasaki K, Shoji T, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T

    Neuro-oncology advances   Vol. 3 ( 1 ) page: vdab038   2021.1

     More details

  2. Blood flow stagnation after treatment of a giant internal carotid artery aneurysm: a computed fluid dynamics analysis.

    Muraoka S, Takagi R, Araki Y, Uda K, Sumitomo M, Okamoto S, Nishihori M, Izumi T, Nakamura M, Saito R

    Scientific reports   Vol. 12 ( 1 ) page: 7283   2022.5

     More details

    Language:English   Publisher:Scientific reports  

    Balloon test occlusion (BTO) is an angiographic test to evaluate ischemic tolerance after permanent occlusion of an internal carotid artery (ICA). BTO can simulate ischemia caused by parent artery occlusion and can be used to select a suitable bypass surgery using specific criteria. On the other hand, a postoperative thrombus can form despite proper case selection, optimal radiological evaluation, and an appropriate surgical strategy. Postoperative ischemic complications related to perforating branches are clinically significant. This simulation study aimed to analyze postoperative flow characteristics and elucidate the cause of ischemic complications related to the perforating branch using computational fluid dynamics (CFD). An unexpected postoperative thrombus formation related to the perforating branch occurred after treating a giant aneurysm in the cavernous portion of the ICA in a patient. Three-dimensional digital subtraction angiography was used to acquire flow data and set up the CFD simulation. The flow simulations were performed at various bypass flow rates. The CFD analysis indicated flow stagnation in the ICA only when surgical treatment using a low-flow bypass graft was performed. Thrombus formation may lead to ischemic complications related to the perforating branch, such as the anterior choroidal artery. BTO did not reflect the influence of bypass blood flow. Therefore, recognizing that blood flow stagnation may occur and comprehensively deciding on the surgical strategy by CFD analysis can be helpful to prevent ischemic complications in patients with giant aneurysms.

    DOI: 10.1038/s41598-022-11321-6

    Scopus

    PubMed

  3. Quick and simple dural threading technique for transsphenoidal surgery - dural tenting, haemostasis and skull base reconstruction

    Takeuchi Kazuhito, Nagata Yuichi, Tanahashi Kuniaki, Saito Ryuta

    ACTA NEUROCHIRURGICA     2022.5

     More details

  4. Medical Management of a Mural Thrombus Inducing Repeated Ischemic Strokes in a Patient with Congenital Afibrinogenemia.

    Nishihori M, Araki Y, Suzuki N, Tamura S, Hattori M, Izumi T, Goto S, Yokoyama K, Uda K, Matsushita T, Saito R

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   Vol. 31 ( 7 ) page: 106526   2022.4

     More details

  5. Radiological analysis of minimally invasive microscopic laminectomy for lumbar canal stenosis with a focus on multilevel stenosis and spondylolisthesis.

    Awaya T, Nishimura Y, Eguchi K, Nagashima Y, Ando R, Akahori S, Yoshikawa S, Haimoto S, Hara M, Takayasu M, Saito R

    World neurosurgery     2022.4

     More details

    Language:English  

    DOI: 10.1016/j.wneu.2022.04.079

    PubMed

  6. Risk Factors for Cerebral Infarction Early After Revascularization in Children Younger than 5 Years with Moyamoya Disease.

    Araki Y, Uda K, Yokoyama K, Kanamori F, Kurimoto M, Shiba Y, Mamiya T, Nishihori M, Takeuchi K, Tanahashi K, Nagata Y, Nishimura Y, Okamoto S, Sumitomo M, Izumi T, Saito R

    World neurosurgery   Vol. 160   page: e220 - e226   2022.4

     More details

    Language:English   Publisher:World Neurosurgery  

    Objective: Cerebral revascularization is necessary for pediatric patients younger than 5 years with moyamoya disease (MMD). However, they have a high risk of developing cerebral infarction early after surgery. This study aimed to analyze the risk factors for developing cerebral infarction among these patients. Methods: The charts of 21 consecutive patients with MMD (39 surgeries) younger than 5 years who had undergone revascularization at our hospital were retrospectively analyzed. Because cerebral infarction occurring within 1 month after surgery was the primary end point, other clinical information was evaluated, including each surgical procedure. Multivariate analysis of the risk factors for postoperative cerebral infarction was performed. Results: Cerebral infarction occurred after 7 of 39 surgeries (17.9%). Of the 39 surgeries, 23 (59%) included direct and indirect combined revascularization. The incidence of cerebral infarction did not differ significantly between the combined (21.7%) and indirect (12.5%) groups (P = 0.46). Logistic regression showed no association between the revascularization procedure and the occurrence of cerebral infarction after surgery (P = 0.3). However, younger age at surgery was correlated with a higher risk of developing cerebral infarction in the early postoperative period (P = 0.05). Conclusions: No differences were found in the risk of developing cerebral infarction early after surgery as a result of surgical procedures. However, younger patients had higher postoperative risk. Further multicenter research should examine this issue for young pediatric patients with moyamoya at high risk of developing cerebral infarction.

    DOI: 10.1016/j.wneu.2021.12.115

    Scopus

    PubMed

  7. Challenging direct bypass surgery for very young children with moyamoya disease: technical notes

    Araki Yoshio, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Kurimoto Michihiro, Shiba Yoshiki, Mamiya Takashi, Nishihori Masahiro, Takeuchi Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Okamoto Sho, Sumitomo Masaki, Izumi Takashi, Saito Ryuta

    NEUROSURGICAL REVIEW   Vol. 45 ( 2 ) page: 1799 - 1807   2022.4

     More details

    Language:Japanese   Publisher:Neurosurgical Review  

    Cerebral revascularization for moyamoya disease (MMD) is an effective treatment for improving cerebral ischaemia and preventing rebleeding. Although direct bypass surgery is commonly performed on older children and adults, it is challenging in very young children due to the high difficulty level of the procedure. The subjects were MMD patients under 3 years of age on whom surgery was performed by a single surgeon (Y.A.). Preoperative clinical findings, information related to direct bypass surgery, bypass patency, and the incidence of postoperative stroke were investigated. Combined revascularization, including direct bypass surgery, was performed on 3 MMD patients (3 sides) under 3 years of age. The average diameter of the grafts used in direct bypass was 0.8 mm. The average recipient diameter was 0.8 ± 0.17 (range 0.6–1) mm. In all cases, the anastomotic procedure was completed using 11–0 monofilament nylon thread, and patency was confirmed. Direct bypass for MMD patients under 3 years old is technically challenging. However, despite the anatomical differences between very young children and elderly individuals, direct bypass surgery could certainly be completed. In addition, a rapid recovery from cerebral blood flow insufficiency could yield a promising neurological outcome.

    DOI: 10.1007/s10143-021-01685-0

    Web of Science

    Scopus

    PubMed

  8. Advantages of petrosectomy for superficial temporal artery to superior cerebellar artery bypass based on three-dimensional distance measurements using cadaver heads

    Uda Kenji, Tanahashi Kuniaki, Mamiya Takashi, Kanamori Fumiaki, Yokoyama Kinya, Nishihori Masahiro, Izumi Takashi, Araki Yoshio, Saito Ryuta

    NEUROSURGICAL REVIEW   Vol. 45 ( 2 ) page: 1617 - 1624   2022.4

     More details

    Language:Japanese   Publisher:Neurosurgical Review  

    Superficial temporal artery (STA) to superior cerebellar artery (SCA) bypass is usually performed via the subtemporal approach (StA), anterior transpetrosal approach (ApA), or combined petrosal approach (CpA), but no study has yet reported a quantitative comparison of the operative field size provided by each approach, and the optimal approach is unclear. The objective of this study is to establish evidence for selecting the approach by using cadaver heads to measure the three-dimensional distances that represent the operative field size for STA–SCA bypass. Ten sides of 10 cadaver heads were used to perform the four approaches: StA, ApA with and without zygomatic arch osteotomy (ApA-ZO− and ApA-ZO+), and CpA. For each approach, the major-axis length and the minor-axis length at the anastomosis site (La-A and Li-A), the major-axis length and the minor-axis length at the brain surface (La-B and Li-B), the depth from the brain surface to the anastomosis site (Dp), and the operating angles of the major axis and the minor axis (OAa and OAi) were measured. Shallower Dp and wider operating angle were obtained in the order CpA, ApA-ZO+, ApA-ZO−, and StA. In all parameters, ApA-ZO− extended the operative field more than StA. ApA-ZO+ extended La-B and OAa more than ApA-ZO−, whereas it did not contribute to Dp and OAi. CpA significantly decreased Dp, and widened OAa and OAi more than ApA-ZO+. ApA and CpA greatly expanded the operative field compared with StA. These results provide criteria for selecting the optimal approach for STA-SCA bypass in light of an individual surgeon’s anastomosis skill level.

    DOI: 10.1007/s10143-021-01686-z

    Web of Science

    Scopus

    PubMed

  9. A novel endoscopic ventriculocisternostomy and stenting technique with a transparent acryl puncture needle for a trapped temporal horn: a technical report and literature review

    Yamamoto Taiki, Takeuchi Kazuhito, Nagata Yuichi, Mizuno Akihiro, Harada Hideyuki, Saito Ryuta

    NEUROSURGICAL REVIEW   Vol. 45 ( 2 ) page: 1783 - 1789   2022.4

     More details

    Language:Japanese   Publisher:Neurosurgical Review  

    Trapped temporal horn is a rare type of noncommunicating focal hydrocephalus, and no standard treatment has been established yet for trapped temporal horn. Recent studies have shown the efficacy of endoscopic ventriculocisternostomy by opening the choroidal fissure; however, some surgical complications were reported during the procedure. Thus, we aimed to report a novel endoscopic ventriculocisternostomy and stenting technique for trapped temporal horn. In this technique, a 5.8-mm transparent acryl puncture needle with a 2.7-mm 0° rigid endoscope was used to open the choroidal fissure. It can fenestrate the choroidal fissure under real-time endoscopic observation of the critical neurovascular structures over the choroidal fissure. Moreover, the dull tip of the needle is less likely to injure the critical neurovascular structures, resulting in safer ventriculocisternostomy than the previously reported technique. Then, a stent is placed along the tract to prevent future obstruction of the stoma. Six trapped temporal horns in four patients were treated using the technique. All the patients showed improved symptoms with no surgical complications. None of the patients showed recurrence of trapped temporal horn during the mean follow-up period of 39.3 months. The combination of endoscopic ventriculocisternostomy and stenting with a transparent acryl puncture needle is a safe and effective treatment option for trapped temporal horn.

    DOI: 10.1007/s10143-021-01634-x

    Web of Science

    Scopus

    PubMed

  10. 特集 脊椎脊髄疾患の再手術症例における手術のコツと留意点 頸椎症における再手術

    西村 由介, 永島 吉孝, 齋藤 竜太

    脊椎脊髄ジャーナル   Vol. 34 ( 12 ) page: 896 - 901   2022.3

     More details

    Publisher:三輪書店  

    DOI: 10.11477/mf.5002201765

    CiNii Research

  11. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

    Iwama Shintaro, Kobayashi Tomoko, Yasuda Yoshinori, Okuji Takayuki, Ito Masaaki, Ando Masahiko, Zhou Xin, Yamagami Ayana, Onoue Takeshi, Kawaguchi Yohei, Miyata Takashi, Sugiyama Mariko, Takagi Hiroshi, Hagiwara Daisuke, Suga Hidetaka, Banno Ryoichi, Hase Tetsunari, Morise Masahiro, Wakahara Keiko, Yokota Kenji, Kato Masashi, Nishio Naoki, Tanaka Chie, Miyata Kazushi, Ogura Atsushi, Ito Takanori, Sawada Tsunaki, Shimokata Tomoya, Niimi Kaoru, Ohka Fumiharu, Ishigami Masatoshi, Gotoh Momokazu, Hashimoto Naozumi, Saito Ryuta, Kiyoi Hitoshi, Kajiyama Hiroaki, Ando Yuichi, Hibi Hideharu, Sone Michihiko, Akiyama Masashi, Kodera Yasuhiro, Arima Hiroshi

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   Vol. 107 ( 4 ) page: E1620 - E1630   2022.3

     More details

    Language:Japanese   Publisher:Journal of Clinical Endocrinology and Metabolism  

    Background: Previous studies showed that although the risk of thyroid dysfunction [thyroid immune-related adverse events (irAEs)] induced by anti-programmed cell death-1 antibodies (PD-1-Ab) was as low as 2% to 7% in patients negative for anti-thyroid antibodies (ATAs) at baseline, it was much higher (30%-50%) in patients positive for ATAs. However, whether a similar increase occurs with combination therapy using PD-1-Ab plus anti-cytotoxic T-lymphocyte antigen-4 antibody (CTLA-4-Ab) is unknown. Methods: A total of 451 patients with malignancies treated with PD-1-Ab, CTLA-4-Ab, or a combination of PD-1-Ab and CTLA-4-Ab (PD-1/CTLA-4-Abs) were evaluated for ATAs at baseline and for thyroid function every 6 weeks for 24 weeks after treatment initiation and then observed until the last clinical visit. Results: Of the 451 patients, 51 developed thyroid irAEs after immunotherapy [41 of 416 (9.9%) treated with PD-1-Ab, 0 of 8 (0%) treated with CTLA-4-Ab, and 10 of 27 (37.0%) treated with PD-1/CTLA-4-Abs]. The cumulative incidence of thyroid irAEs was significantly higher in patients who were positive vs negative for ATAs at baseline after both PD-1-Ab [28/87 (32.2%) vs 13/329 (4.0%), P < 0.001] and PD-1/CTLA-4-Abs [6/10 (60.0%) vs 4/17 (23.5%), P < 0.05] treatments. The risk of thyroid irAEs induced by PD-1/CTLA-4Abs, which was significantly higher than that induced by PD-1-Ab, in patients negative for ATAs at baseline was not statistically different from that induced by PD-1-Ab in patients positive for ATAs at baseline. Conclusions: This study showed that the incidence of thyroid irAEs was high and not negligible after PD-1/CTLA-4-Abs treatment even in patients negative for ATAs at baseline.

    DOI: 10.1210/clinem/dgab829

    Web of Science

    Scopus

    PubMed

  12. Changes in cerebral blood flow in the postoperative chronic phase after combined cerebral revascularization for moyamoya disease with ischaemic onset

    Araki Yoshio, Mamiya Takashi, Fujita Naotoshi, Uda Kenji, Yokoyama Kinya, Kanamori Fumiaki, Takayanagi Kai, Ishii Kazuki, Nishihori Masahiro, Takeuch Kazuhito, Tanahashi Kuniaki, Nagata Yuichi, Nishimura Yusuke, Tanei Takafumi, Sumitomo Masaki, Okamoto Sho, Izumi Takashi, Kato Katsuhiko, Saito Ryuta

    NEUROSURGICAL REVIEW     2022.3

     More details

    Language:Japanese   Publisher:Neurosurgical Review  

    The purpose of this study was to examine the effects of combined revascularization for ischaemic-onset moyamoya disease (MMD) on cerebral haemodynamics by comparing cerebral blood flow (CBF) during the postoperative chronic phase with preoperative CBF. A retrospective cohort of 24 MMD patients (representing 31 surgeries) who received single photon emission computed tomography (SPECT) before and more than 6 months after surgery was investigated. The CBF value of each vascular territory was extracted from SPECT data, and the value relative to the ipsilateral cerebellar value (relative CBF, or RCBF) was calculated. The correlation between the revascularization effect and the proportional change in RCBF before and after surgery (calculated as post-RCBF/pre-RCBF (“post/pre-RCBF”)) was analysed. Furthermore, the relationships between changes in neurological symptoms and post/pre-RCBF were investigated. Preoperative and postoperative mean RCBF values were 0.92 ± 0.15 and 0.96 ± 0.13 (p = 0.619) in the anterior cerebral artery territory, 0.99 ± 0.17 and 1.01 ± 0.17 (p = 0.598) in the middle cerebral artery territory and 1.15 ± 0.22 and 1.14 ± 0.19 (p = 0.062) in the posterior cerebral artery territory, respectively. No significant correlation was found between the revascularization score and post/pre-RCBF. The revascularization score and post/pre-RCBF were not significant predictors of worsening neurological symptoms postoperatively. No significant change in RCBF was observed in any vascular territory in the chronic phase after revascularization. Combined revascularization may assist in the redirection of blood flow from the internal to the external carotid system and contribute to CBF maintenance.

    DOI: 10.1007/s10143-022-01774-8

    Web of Science

    Scopus

    PubMed

  13. Modified Shoelace Dural Closure with Collagen Matrix in Extended Transsphenoidal Surgery

    NAGATA Yuichi, TAKEUCHI Kazuhito, SASAKI Hiroo, MIZUNO Akihiro, HARADA Hideyuki, TANAHASHI Kuniaki, ARAKI Yoshio, SAITO Ryuta

    Neurologia medico-chirurgica   Vol. 62 ( 4 ) page: 203 - 208   2022.3

     More details

    Language:Japanese   Publisher:The Japan Neurosurgical Society  

    DOI: 10.2176/jns-nmc.2021-0355

    Web of Science

    Scopus

    PubMed

    CiNii Research

  14. [Diffuse midline glioma].

    Saito R

    No shinkei geka. Neurological surgery   Vol. 50 ( 1 ) page: 29 - 38   2022.1

     More details

    Language:Japanese   Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1436204529

    PubMed

    CiNii Research

  15. Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas

    Nishikawa Tomohide, Watanabe Reiko, Kitano Yotaro, Yamamichi Akane, Motomura Kazuya, Ohka Fumiharu, Aoki Kosuke, Hirano Masaki, Kato Akira, Yamaguchi Junya, Maeda Sachi, Kibe Yuji, Saito Ryuta, Wakabayashi Toshihiko, Kato Yukinari, Sato Shuta, Ogino Tomoyoshi, Natsume Atsushi, Ito Ichiro

    BRAIN TUMOR PATHOLOGY   Vol. 39 ( 1 ) page: 14 - 24   2022.1

     More details

    Language:Japanese   Publisher:Brain Tumor Pathology  

    Since the World Health Organization 2016 classification (2016 WHO), genetic status has been incorporated into the diagnosis of Grade 2/3 gliomas (lower-grade gliomas). Therefore, immunohistochemistry (IHC) of IDH1-R132H, ATRX, and p53 have been used in place of genetic status. We report the associations between histological findings, IHC, and genetic status. We performed IHC of IDH1-R132H, ATRX, and p53 in 76 lower-grade gliomas and discussed its validity based on the 2016 WHO and the upcoming 2021 WHO classification. The sensitivity and specificity of anti-ATRX, p53, and IDH1-R132H IHC were 40.9%/98.1%, 78.6%/85.4%, and 90.5%/84.6%, respectively. Among 21 IDH1-mutant gliomas without 1p/19q codeletion, two gliomas (9.5%) mimicked the so-called classic for oligodendroglioma (CFO) in their morphology. Of the 42 gliomas with 1p/19q codeletion, four cases were difficult to diagnose as oligodendroglioma through morphological examination. Moreover, there were three confusing cases with ATRX mutations but with retained ATRX-IHC positivity. The lessons learned from this study are as follows: (1) ATRX-IHC and p53-IHC should be supplementary to morphological diagnosis, (2) rare IDH mutations other than IDH1 R132H should be considered, and (3) there is no complete alternative test to detect molecular features of glioblastoma under the 2021 WHO classification.

    DOI: 10.1007/s10014-021-00418-x

    Web of Science

    Scopus

    PubMed

  16. Multitier Network Analysis Using Resting-state Functional MRI for Epilepsy Surgery

    MAESAWA Satoshi, BAGARINAO Epifanio, NAKATSUBO Daisuke, ISHIZAKI Tomotaka, TAKAI Sou, TORII Jun, KATO Sachiko, SHIBATA Masashi, WAKABAYASHI Toshihiko, SAITO Ryuta

    Neurologia medico-chirurgica   Vol. 62 ( 1 ) page: 45 - 55   2022.1

     More details

    Language:Japanese   Publisher:The Japan Neurosurgical Society  

    <p>Resting-state functional MRI (rs-fMRI) has been utilized to visualize large-scale brain networks. We evaluated the usefulness of multitier network analysis using rs-fMRI in patients with focal epilepsy. Structural and rs-fMRI data were retrospectively evaluated in 20 cases with medically refractory focal epilepsy, who subsequently underwent surgery. First, structural changes were examined using voxel-based morphometry analysis. Second, alterations in large-scale networks were evaluated using dual-regression analysis. Third, changes in cortical hubs were analyzed and the relationship between aberrant hubs and the epileptogenic zone (EZ) was evaluated. Finally, the relationship between the hubs and the default mode network (DMN) was examined using spectral dynamic causal modeling (spDCM). Dual-regression analysis revealed significant decrease in functional connectivity in several networks including DMN in patients, although no structural difference was seen between groups. Aberrant cortical hubs were observed in and around the EZ (EZ hubs) in 85% of the patients, and a strong degree of EZ hubs correlated to good seizure outcomes postoperatively. In spDCM analysis, facilitation was often seen from the EZ hub to the contralateral side, while inhibition was seen from the EZ hub to nodes of the DMN. Some cognition-related networks were impaired in patients with focal epilepsy. The EZ hub appeared in the vicinity of EZ facilitating connections to distant regions in the early phase, which may eventually generate secondary focus, while inhibiting connections to the DMN, which may cause cognitive deterioration. Our results demonstrate pathological network alterations in epilepsy and suggest that earlier surgical intervention may be more effective.</p>

    DOI: 10.2176/nmc.oa.2021-0173

    Web of Science

    Scopus

    PubMed

    CiNii Research

  17. Contrast-Enhanced Magnetic Resonance Imaging Suggested a Possibility of Transvenous Embolization in the Superior Petrosal Sinus Dural Arteriovenous Fistula: A Case Report

    Nishihori Masahiro, Izumi Takashi, Tsukada Tetsuya, Kato Yutaka, Uda Kenji, Yokoyama Kinya, Araki Yoshio, Saito Ryuta

    Journal of Neuroendovascular Therapy   Vol. 16 ( 3 ) page: 163 - 169   2022

     More details

    Language:English   Publisher:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective</b>: Superior petrosal sinus dural arteriovenous fistula (SPS-DAVF) is a rare subtype of intracranial DAVF that sometimes leads to hemorrhagic symptoms following deep venous drainage. Here we report the case of SPS-DAVF with retrograde venous reflux to the cerebellar vein. Preoperative contrast-enhanced MRI was a decisive factor in a safe and effective treatment.</p><p><b>Case presentation</b>: A 37-year-old woman was referred to our hospital with abnormal MRI findings, which was performed when she had a mild headache during her check-up. DSA revealed left-sided SPS-DAVF, which was diagnosed as Cognard type IIb. Both CTA and DSA could not detect the whole SPS but only the shunt pouch. Using contrast-enhanced MRI, we were able to visualize the presence of the SPS and its continuity within the shunt pouch. 3D-T1 turbo spin echo (SPACE) showed a low-intensity area in the SPS, which was not seen in the 3D-T1 fast field echo (FFE). During the procedure, there was a point where it was difficult to advance the microcatheter, which coincided with the low-intensity area. We achieved effective transvenous embolization from the occluded venous access by devising a surgical technique.</p><p><b>Conclusion</b>: In addition to the contrast-enhanced 3D-T1 FFE, 3D-T1 SPACE might provide beneficial information for endovascular therapy in the evaluation of venous sinuses, which could not be detected by standard examinations.</p>

    DOI: 10.5797/jnet.cr.2021-0029

    CiNii Research

  18. Role of the parietooccipital fissure and its implications in the pathophysiology of posterior medial temporal gliomas.

    Shibahara I, Saito R, Kanamori M, Sonoda Y, Sato S, Hide T, Tominaga T, Kumabe T

    Journal of neurosurgery     page: 1 - 10   2021.12

     More details

    Language:English  

    DOI: 10.3171/2021.7.JNS21990

    PubMed

  19. Two cases of solitary fibrous tumor/hemangiopericytoma with different clinical features according to the World Health Organization classification: case report and review of the literature.

    Nishii T, Nagashima Y, Nishimura Y, Ito H, Oyama T, Matsuo M, Sakakibara A, Shimada S, Saito R

    Journal of spine surgery (Hong Kong)   Vol. 7 ( 4 ) page: 532 - 539   2021.12

     More details

    Language:English  

    DOI: 10.21037/jss-21-83

    PubMed

  20. Clinical and Radiological Clues of Traumatic Craniocervical Junction Injuries Requiring Occipitocervical Fusion to Early Diagnosis

    Shiraishi Daimon, Nishimura Yusuke, Aguirre-Carreno Isaac, Hara Masahito, Yoshikawa Satoshi, Eguchi Kaoru, Nagashima Yoshitaka, Ito Hiroshi, Haimoto Shoichi, Yamamoto Yu, Ginsberg Howard J., Takayasu Masakazu, Saito Ryuta

    NEUROSPINE   Vol. 18 ( 4 ) page: 741 - 748   2021.12

     More details

    Language:Japanese   Publisher:Neurospine  

    Objective: The purpose of this study is to find the clinical and radiographic characteristics of traumatic craniocervical junction (CCJ) injuries requiring occipitocervical fusion (OC fusion) for early diagnosis and surgical intervention. Methods: We retrospectively reviewed 12 patients with CCJ injuries presenting to St. Mi-chaels Hospital in Toronto who underwent OC fusion and looked into the following vari-ables; (1) initial trauma data on emergency room arrival, (2) associated injuries, (3) imaging characteristics of computed tomography (CT) scan and magnetic resonance imaging (MRI), (4) surgical procedures, surgical complications, and neurological outcome. Results: All patients were treated as acute spinal injuries and underwent OC fusion on an emergency basis. Patients consisted of 10 males and 2 females with an average age of 47 years (range, 18–82 years). All patients sustained high-energy injuries. Three patients out of 6 patients with normal BAI (basion-axial interval) and BDI (basion-dens interval) values showed visible CCJ injuries on CT scans. However, the remaining 3 patients had no clear evidence of occipitoatlantal instability on CT scans. MRI clearly described several findings indicating occipitoatlantal instability. The 8 patients with normal values of ADI (atlanto-dens interval interval) demonstrated atlantoaxial instability on CT scan, however, all MRI more clearly and reliably demonstrated C1/2 facet injury and/or cruciate ligament injury. Conclusion: We advocate measures to help recognize CCJ injury at an early stage in the present study. Occipitoatlantal instability needs to be carefully investigated on MRI in addition to CT scan with special attention to facet joint and ligament integrity.

    DOI: 10.14245/ns.2142860.430

    Web of Science

    Scopus

    PubMed

  21. A Super-selective Wada Test Successfully Detected an Artery That Supplied Broca's Area in a Case of Left Frontal Lobe Glioblastoma: Technical Case Report.

    Yamashita S, Saito R, Osawa SI, Niizuma K, Ukishiro K, Kanamori M, Kakinuma K, Suzuki K, Tominaga T

    Neurologia medico-chirurgica   Vol. 61 ( 11 ) page: 661 - 666   2021.11

     More details

    Language:English  

    DOI: 10.2176/nmc.tn.2021-0054

    PubMed

  22. Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging

    Maesawa Satoshi, Mizuno Satomi, Bagarinao Epifanio, Watanabe Hirohisa, Kawabata Kazuya, Hara Kazuhiro, Ohdake Reiko, Ogura Aya, Mori Daisuke, Nakatsubo Daisuke, Isoda Haruo, Hoshiyama Minoru, Katsuno Masahisa, Saito Ryuta, Ozaki Norio, Sobue Gen

    FRONTIERS IN HUMAN NEUROSCIENCE   Vol. 15   page: 753836   2021.11

     More details

    Language:Japanese   Publisher:Frontiers in Human Neuroscience  

    Purpose: Maintenance of cognitive performance is important for healthy aging. This study aims to elucidate the relationship between brain networks and cognitive function in subjects maintaining relatively good cognitive performance. Methods: A total of 120 subjects, with equal number of participants from each age group between 20 and 70 years, were included in this study. Only participants with Addenbrooke’s Cognitive Examination – Revised (ACE-R) total score greater than 83 were included. Anatomical T1-weighted MR images and resting-state functional MR images (rsfMRIs) were taken from all participants using a 3-tesla MRI scanner. After preprocessing, several factors associated with age including the ACE-R total score, scores of five domains, sub-scores of ACE-R, and brain volumes were tested. Morphometric changes associated with age were analyzed using voxel based morphometry (VBM) and changes in resting state networks (RSNs) were examined using dual regression analysis. Results: Significant negative correlations with age were seen in the total gray matter volume (GMV, r = −0.58), and in the memory, attention, and visuospatial domains. Among the different sub-scores, the score of the delayed recall (DR) showed the highest negative correlation with age (r = −0.55, p < 0.001). In VBM analysis, widespread regions demonstrated negative correlation with age, but none with any of the cognitive scores. Quadratic approximations of cognitive scores as functions of age showed relatively delayed decline compared to total GMV loss. In dual regression analysis, some cognitive networks, including the dorsal default mode network, the lateral dorsal attention network, the right / left executive control network, the posterior salience network, and the language network, did not demonstrate negative correlation with age. Some regions in the sensorimotor networks showed positive correlation with the DR, memory, and fluency scores. Conclusion: Some domains of the cognitive test did not correlate with age, and even the highly correlated sub-scores such as the DR score, showed delayed decline compared to the loss of total GMV. Some RSNs, especially involving cognitive control regions, were relatively maintained with age. Furthermore, the scores of memory, fluency, and the DR were correlated with the within-network functional connectivity values of the sensorimotor network, which supported the importance of exercise for maintenance of cognition.

    DOI: 10.3389/fnhum.2021.753836

    Web of Science

    Scopus

    PubMed

  23. Aphasic status epilepticus after glioma resection: two case reports.

    Shimoda Y, Kanamori M, Saito R, Osawa S, Mugikura S, Tominaga T

    Acta neurochirurgica   Vol. 163 ( 11 ) page: 3109 - 3113   2021.11

     More details

    Language:English  

    DOI: 10.1007/s00701-021-04984-z

    PubMed

  24. Techniques, Indications, and Outcomes in Magnetic Resonance-guided Focused Ultrasound Thalamotomy for Tremor

    MAESAWA Satoshi, NAKATSUBO Daisuke, TSUGAWA Takahiko, KATO Sachiko, SHIBATA Masashi, TAKAI Sou, TORII Jun, ISHIZAKI Tomotaka, WAKABAYASHI Toshihiko, SAITO Ryuta

    Neurologia medico-chirurgica   Vol. 61 ( 11 ) page: 629 - 639   2021.11

     More details

    Language:Japanese   Publisher:The Japan Neurosurgical Society  

    <p>Magnetic resonance (MR)-guided focused ultrasound surgery (MRgFUS) is the latest minimally invasive stereotactic procedure, and thalamotomy using this novel modality has demonstrated its effectiveness and safety, especially for patients with essential tremor (ET) and Parkinson’s disease (PD). In Japan, the application of MRgFUS to treat ET and PD has recently been covered by health insurance. Technically, the transducer with 1024 elements emits ultrasound beams, which are then focused on the target with a phase control, resulting in optimal ablation by thermal coagulation. The technical advantages of MRgFUS are continuous intraoperative monitoring of clinical symptoms and MR images and fine adjustment of the target by the steering function. Postoperative tremor control is compatible with other modalities, although long-term follow-up is necessary. The adverse effects are usually transient and acceptable. Prognostic factors for good tremor control include high temperature and large lesion size. A high skull density ratio is a factor to achieve high temperature and large lesioning, but it may not be necessary and sufficient for clinical outcomes. For patients with advanced symptoms such as bilateral tremor or head/neck tremor, deep brain stimulation may be recommended because of the adjustability of stimulation and the possibility of bilateral treatment. Patients have high expectations of MRgFUS because of its non-invasiveness. To perform this treatment safely and effectively, physicians need to understand the technological aspects, the physiological principles. To choose the appropriate modality, physicians also should recognize the clinical advantages and disadvantages of MRgFUS compared to other modalities.</p>

    DOI: 10.2176/nmc.ra.2021-0187

    Web of Science

    Scopus

    PubMed

    CiNii Research

  25. Newly established patient-derived organoid model of intracranial meningioma

    Yamazaki Shintaro, Ohka Fumiharu, Hirano Masaki, Shiraki Yukihiro, Motomura Kazuya, Tanahashi Kuniaki, Tsujiuchi Takashi, Motomura Ayako, Aoki Kosuke, Shinjo Keiko, Murofushi Yoshiteru, Kitano Yotaro, Maeda Sachi, Kato Akira, Shimizu Hiroyuki, Yamaguchi Junya, Adilijiang Alimu, Wakabayashi Toshihiko, Saito Ryuta, Enomoto Atsushi, Kondo Yutaka, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 23 ( 11 ) page: 1936 - 1948   2021.11

     More details

    Language:Japanese   Publisher:Neuro-Oncology  

    Background: Recent comprehensive studies have revealed several molecular alterations that are frequently found in meningiomas. However, effective treatment reagents targeting specific molecular alterations have not yet been identified because of the limited number of representative research models of meningiomas. Methods: We performed organoid cultures using meningioma cells and meningioma tumor tissues. Using immunohistochemistry and molecular analyses consisting of whole-exome sequencing, RNA-seq, and DNA methylation analyses, we compared the histological findings and molecular profiling of organoid models with those of parental tumors. Further, using these organoid models together with a public database of meningiomas, we explored molecular alterations, which are a potent treatment target for meningioma. Results: We established 18 organoid models comprising of two malignant meningioma cells (HKBMM and IOMM-Lee), 10 benign meningiomas, four malignant meningiomas, and two solitary fibrous tumors (SFTs). The organoids exhibited consistent histological features and molecular profiles with those of the parental tumors. Using a public database, we identified that upregulated forkhead box M1 (FOXM1) was correlated with increased tumor proliferation. Overexpression of FOXM1 in benign meningioma organoids increased organoid proliferation; depletion of FOXM1 in malignant organoids decreased proliferation. Additionally, thiostrepton, a FOXM1 inhibitor combined with radiation therapy, significantly inhibited the proliferation of malignant meningioma organoid models. Conclusions: An organoid model for meningioma enabled us to elucidate the tumor biology of meningioma along with potent treatment targets for meningioma.

    DOI: 10.1093/neuonc/noab155

    Web of Science

    Scopus

    PubMed

  26. Effects of oxytocin on responses to nociceptive and non-nociceptive stimulation in the upper central nervous system

    Saito Hidehisa, Hidema Shizu, Otsuka Ayano, Suzuki Jun, Kumagai Michio, Kanaya Akihiro, Murakami Toru, Takei Yusuke, Saito Kazutomo, Sugino Shigekazu, Toyama Hiroaki, Saito Ryuta, Tominaga Teiji, Nishimori Katsuhiko, Yamauchi Masanori

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 574   page: 8 - 13   2021.10

     More details

    Language:Japanese   Publisher:Biochemical and Biophysical Research Communications  

    Oxytocin is known as a social bonding hormone, but it also functions as an anxiolytic or analgesic neurotransmitter. When oxytocin regulates pain or anxiousness centrally as a neurotransmitter, it is secreted by neurons and directly projected to targeted regions. Although the function of oxytocin at the spinal level is well studied, its effects at the supraspinal level are poorly understood. We aimed to investigate the effect of oxytocin at the supraspinal level in vivo using C57BL/6J (wild-type [WT]), oxytocin-deficient (Oxt−/−), oxytocin receptor-deficient (Oxtr−/−), and oxytocin receptor-Venus (OxtrVenus/+) mice lines. Response thresholds in Oxtr−/− mice in Hargreaves and von-Frey tests were significantly lower than those in WT mice, whereas open field and light/dark tests showed no significant differences. Moreover, response thresholds in Oxt−/− mice were raised to those in WT mice after oxytocin administration. Following the Hargreaves test, we observed the co-localisation of c-fos with Venus or the oxytocin receptor in the periaqueductal gray (PAG), medial amygdala (MeA), and nucleus accumbens (NAc) regions in OxtrVenus/+ mice. Furthermore, in the PAG, MeA, and NAc regions, the co-localisation of oxytocin with c-fos and gamma-aminobutyric acid was much stronger in Oxtr−/− mice than in WT mice. However, following von-Frey test, the same findings were observed only in the MeA and NAc regions. Our results suggest that oxytocin exerts its analgesic effect on painful stimulation via the PAG region and a self-protective effect on unpleasant stimulation via the MeA and NAc regions.

    DOI: 10.1016/j.bbrc.2021.08.042

    Web of Science

    Scopus

    PubMed

  27. Triggering of Carotid Sinus Reflex during Deployment of the Flow-diverter Device

    GOTO Shunsaku, IZUMI Takashi, NISHIHORI Masahiro, TSUKADA Tetsuya, ARAKI Yoshio, UDA Kenji, YOKOYAMA Kinya, SAITO Ryuta

    Neurologia medico-chirurgica   Vol. 61 ( 10 ) page: 583 - 590   2021.10

     More details

    Language:Japanese   Publisher:The Japan Neurosurgical Society  

    <p>The carotid sinus reflex (CSR) is a rare complication of the Pipeline Embolization Device (PED) deployment. No study has assessed the potential risk factors in a case series. The purpose of this study was to examine CSR triggering during PED deployment. Thirty-seven consecutive patients who underwent PED deployment were included. All procedures were performed under local anesthesia with mild sedation. We retrospectively analyzed patient characteristics, PED deployment time, and vital signs during the procedure. The vital signs included the pulse rate (PR) and systolic blood pressure (SBP) obtained at three timepoints (pre-deployment, during deployment, post-deployment). We examined the triggering of the CSR during PED deployment by comparing the vital signs at the three timepoints. Moreover, risk factors for CSR were analyzed with univariate analysis. The patients’ average age was 66.3 years. The average size of the aneurysm was 18.0 mm. Six patients (16.2%) showed a decline in the SBP or PR defined as CSR. One patient had a transient cardiac arrest and two had severe transient bradycardia. Deployment into the ophthalmic segment of the internal carotid artery (C2 segment) aneurysm (p = 0.022), prolonged PED deployment time more than 14.5 minutes (p = 0.005), and an acute angle of the anterior genu less than 51.5 degrees (p = 0.005) were risk factors in triggering CSR. CSR may be triggered during PED deployment under local anesthesia with mild sedation. Deployment to the C2 segment aneurysm, prolonged PED deployment time, and an acute angle of the anterior genu were associated with CSR triggering.</p>

    DOI: 10.2176/nmc.oa.2021-0049

    Web of Science

    Scopus

    PubMed

    CiNii Research

  28. Sellar arachnoid cystに対する経鼻内視鏡手術

    永田 雄一, 竹内 和人, 山本 太樹, 水野 晃宏, 永谷 哲也, 齋藤 竜太

    日本内分泌学会雑誌   Vol. 97 ( S.HPT ) page: 49 - 51   2021.9

     More details

    Language:Japanese   Publisher:一般社団法人 日本内分泌学会  

    DOI: 10.1507/endocrine.97.s.hpt_49

    CiNii Research

  29. 内視鏡下経鼻頭蓋底手術後の再建戦略

    竹内 和人, 永田 雄一, 山本 太樹, 原田 英幸, 齋藤 竜太

    日本内分泌学会雑誌   Vol. 97 ( S.HPT ) page: 16 - 18   2021.9

     More details

    Language:Japanese   Publisher:一般社団法人 日本内分泌学会  

    DOI: 10.1507/endocrine.97.s.hpt_16

    CiNii Research

  30. Evaluation of the differences in pressure applied to the vessel wall by different types of balloon remodeling microcatheters in an experimental model

    Ikezawa Mizuka, Izumi Takashi, Nishihori Masahiro, Tsukada Tetsuya, Tamari Yosuke, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Goto Shunsaku, Kropp Asuka E., Otsuka Takafumi, Kato Naoki, Nakano Mizuki, Saito Ryuta

    INTERVENTIONAL NEURORADIOLOGY     page: 15910199211031765   2021.9

     More details

    Language:Japanese   Publisher:Interventional Neuroradiology  

    Background: We examined compliance differences among balloon remodeling microcatheters, which have not been established previously. Methods: Straight and 120° angulated vascular models were created in a 3 mm diameter tube with 3 mm hole (vascular model A), a tube with a 4 mm hole (vascular model B), and a 4 mm diameter tube (vascular model C). We compared the pressure exerted when each balloon was herniated 1 or 2 mm between three compliant balloons (SHOURYU SR, TransForm C, and Scepter C) and four super-compliant balloons (HyperForm, SHOURYU HR, TransForm SC, and Scepter XC). Results: In vascular model A, there was a significant difference in the pressure exerted by compliant balloons and super-compliant balloons in both the straight and angulated models. In the straight model (1 and 2 mm), the lowest pressure was exerted by HyperForm (super-compliant balloons group) and SHOURYU SR (compliant balloons group). The lowest pressure was exerted in the angulated model by HyperForm (super-compliant balloons group) and Scepter C (compliant balloons group). The Scepter balloon exerted higher pressure in the straight model than other balloon remodeling microcatheters but less in the angulated model. In vascular model B, the pressure decreased in all balloons compared with model A. In vascular model C, the pressure increased in all balloons compared with model A. Conclusions: Pressure differed across balloon remodeling microcatheters. In addition, vessel shape and diameter, and hole size, affected the results. Our findings can help select balloon remodeling microcatheters.

    DOI: 10.1177/15910199211031765

    Web of Science

    Scopus

    PubMed

  31. Mathematical Modeling and Mutational Analysis Reveal Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas

    Aoki Kosuke, Suzuki Hiromichi, Yamamoto Takashi, Yamamoto Kimiyo N., Maeda Sachi, Okuno Yusuke, Ranjit Melissa, Motomura Kazuya, Ohka Fumiharu, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Shimizu Hiroyuki, Kitano Yotaro, Yamaguchi Junya, Yamazaki Shintaro, Nakamura Hideo, Takahashi Masamichi, Narita Yoshitaka, Nakada Mitsutoshi, Deguchi Shoichi, Mizoguchi Masahiro, Momii Yasutomo, Muragaki Yoshihiro, Abe Tatsuya, Akimoto Jiro, Wakabayashi Toshihiko, Saito Ryuta, Ogawa Seishi, Haeno Hiroshi, Natsume Atsushi

    CANCER RESEARCH   Vol. 81 ( 18 ) page: 4861 - 4873   2021.9

     More details

    Language:Japanese   Publisher:Cancer Research  

    Isocitrate dehydrogenase-mutant low-grade gliomas (IDHmut- LGG) grow slowly but frequently undergo malignant transformation, which eventually leads to premature death. Chemotherapy and radiotherapy treatments prolong survival, but can also induce genetic (or epigenetic) alterations involved in transformation. Here, we developed a mathematical model of tumor progression based on serial tumor volume data and treatment history of 276 IDHmut- LGGs classified by chromosome 1p/19q codeletion (IDHmut/ 1p19qcodel and IDHmut/1p19qnoncodel) and performed genomewide mutational analyses, including targeted sequencing and longitudinal whole-exome sequencing data. These analyses showed that tumor mutational burden correlated positively with malignant transformation rate, and chemotherapy and radiotherapy significantly suppressed tumor growth but increased malignant transformation rate per cell by 1.8 to 2.8 times compared with before treatment. This model revealed that prompt adjuvant chemoradiotherapy prolonged malignant transformation-free survival in small IDHmut-LGGs (≤ 50 cm3). Furthermore, optimal treatment differed according to genetic alterations for large IDHmut-LGGs (> 50 cm3); adjuvant therapies delayed malignant transformation in IDHmut/1p19qnoncodel but often accelerated it in IDHmut/1p19qcodel. Notably, PI3K mutation was not associated with malignant transformation but increased net postoperative proliferation rate and decreased malignant transformation-free survival, prompting the need for adjuvant therapy in IDHmut/1p19qcodel. Overall, this model uncovered therapeutic strategies that could prevent malignant transformation and, consequently, improve overall survival in patients with IDHmut-LGGs.

    DOI: 10.1158/0008-5472.CAN-21-0985

    Web of Science

    Scopus

    PubMed

  32. [Magnetic Resonance-guided Focused Ultrasound Ablation:Techniques and Neurological Applications].

    Maesawa S, Nakatsubo D, Tsugawa T, Kato S, Shibata M, Takai S, Torii J, Wakabayashi T, Saito R

    No shinkei geka. Neurological surgery   Vol. 49 ( 4 ) page: 847 - 856   2021.7

     More details

    Language:Japanese   Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1436204463

    PubMed

    CiNii Research

  33. Association between IDH mutational status and tumor-associated epilepsy or venous thromboembolism in patients with grade II and III astrocytoma.

    Osada Y, Saito R, Miyata S, Shoji T, Shibahara I, Kanamori M, Sonoda Y, Kumabe T, Watanabe M, Tominaga T

    Brain tumor pathology   Vol. 38 ( 3 ) page: 218 - 227   2021.7

     More details

    Language:English  

    DOI: 10.1007/s10014-021-00406-1

    PubMed

  34. Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping

    Motomura Kazuya, Chalise Lushun, Ohka Fumiharu, Aoki Kosuke, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Yamaguchi Junya, Shimizu Hiroyuki, Wakabayashi Toshihiko, Saito Ryuta

    JOURNAL OF NEURO-ONCOLOGY   Vol. 153 ( 2 ) page: 361 - 372   2021.6

     More details

    Language:Japanese   Publisher:Journal of Neuro-Oncology  

    Purpose: The aim of this study was to assess the effect of the extent of resection (EOR) of tumors on survival in a series of patients with grade II and III gliomas (GII/III-gliomas) who underwent awake brain mapping. Methods: We retrospectively analyzed 126 patients with GII/III-gliomas in the dominant and non-dominant hemisphere who underwent awake brain surgery at the same institution between December 2012 and May 2020. Results: EOR cut-off values for improved progression-free survival (PFS) were determined by a receiver operator characteristic (ROC) analysis of 5-year PFS. The ROC for EOR showed a cut-off value of ≥ 85.3%. The median PFS rate of patients with GII/III-gliomas in the group with an EOR ≥ 100%, including supratotal resection (n = 47; median survival [MS], not reached), was significantly higher than that in the group with an EOR < 90% (n = 52; MS, 43.1 months; 95% CI 37.7–48.5 months; p = 0.03). In patients with diffuse astrocytomas and anaplastic astrocytomas, the group with EOR ≥ 100%, including supratotal resection (n = 25; MS, not reached), demonstrated a significantly better PFS rate than did the group with an EOR < 100% (n = 45; MS, 35.8 months; 95% CI 19.9–51.6 months; p = 0.03). Supratotal or gross total resection was correlated with better PFS in IDH-mutant type of diffuse astrocytomas and anaplastic astrocytomas (n = 19; MS, not reached vs. n = 35; MS, 40.6 months; 95% CI 22.3–59.0 months; p = 0.02). By contrast, supratotal or gross total resection was not associated with longer PFS rates in patients with IDH-wild type of diffuse astrocytomas and anaplastic astrocytomas. Conclusions: The present study demonstrates a significant association between tumor EOR and survival in patients with GII/III gliomas. The EOR cut-off value for 5-year PFS was ≥ 85.3%. It is noteworthy that supratotal or gross total resection significantly correlated with better PFS in IDH-mutant type of WHO grade II and III astrocytic tumors. In light of our finding that EOR did not correlate with PFS in patients with aggressive IDH-wild type of diffuse astrocytomas and anaplastic astrocytomas, we suggest treatments that are more intensive will be needed for the control of these tumors.

    DOI: 10.1007/s11060-021-03776-w

    Web of Science

    Scopus

    PubMed

  35. Orengedokuto and shosaikoto for intractable intracranial carmustine implant-induced fever in a patient with brain tumor: A case report.

    Suzuki S, Takayama S, Kikuchi A, Arita R, Abe M, Saito R, Kanamori M, Tominaga T, Ishii T

    Explore (New York, N.Y.)   Vol. 17 ( 3 ) page: 236 - 238   2021.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.explore.2020.08.014

    PubMed

  36. Postcentral gyrus resection of opercular gliomas is a risk factor for motor deficits caused by damaging the radiologically invisible arteries supplying the descending motor pathway.

    Shibahara I, Sato S, Hide T, Saito R, Kanamori M, Sonoda Y, Tominaga T, Kumabe T

    Acta neurochirurgica   Vol. 163 ( 5 ) page: 1269 - 1278   2021.5

     More details

    Language:English  

    DOI: 10.1007/s00701-021-04737-y

    PubMed

  37. [Chemotherapy for Glioma].

    Saito R

    No shinkei geka. Neurological surgery   Vol. 49 ( 3 ) page: 588 - 596   2021.5

     More details

    Language:Japanese   Publisher:株式会社医学書院  

    DOI: 10.11477/mf.1436204432

    PubMed

    CiNii Research

  38. Effect of endoscope flexibility on tissue dissection profile assessed with pulsed water jet device: ensuring safety, efficacy, and handling of thin devices for neuroendoscopic surgery.

    Kusunoki T, Kawaguchi T, Nakagawa A, Noguchi Y, Osawa SI, Endo H, Endo T, Saito R, Kanamori M, Niizuma K, Tominaga T

    BMC research notes   Vol. 14 ( 1 ) page: 64   2021.2

  39. Hepatitis B virus reactivation during temozolomide administration for malignant glioma.

    Shoji T, Kanamori M, Inoue J, Saito R, Osada Y, Shimoda Y, Chonan M, Uenohara H, Masamune A, Tominaga T

    International journal of clinical oncology   Vol. 26 ( 2 ) page: 305 - 315   2021.2

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10147-020-01814-7

    PubMed

  40. 覚醒下手術中痙攣発作コントロールにおけるレベチラセタム・ペランパネル併用療法の有効性について

    本村 和也, 齋藤 竜太

    神経治療学   Vol. 38 ( 6 ) page: S211 - S211   2021

     More details

    Language:Japanese   Publisher:日本神経治療学会  

    DOI: 10.15082/jsnt.38.6_s211

    CiNii Research

  41. An Approach to Superior Petrosal Sinus via Contralateral Superior Petrosal Sinus in a Case of Dural Arteriovenous Fistulas with Difficulty in Access

    SUZUKI Keita, NISHIHORI Masahiro, IZUMI Takashi, SUZUKI Osamu, MUTO Manabu, ARAKI Yoshio, UDA Kenji, YOKOYAMA Kinya, SAITO Ryuta

    No Kekkannai Chiryo   Vol. 6 ( 3 ) page: 161 - 168   2021

     More details

    Language:Japanese   Publisher:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective</b>: Herein, we report a case of multiple dural arteriovenous fistulas (DAVFs) in the left superior petrosal sinus (SPS) successfully treated by transvenous embolization via the right SPS.</p><p><b>Case Presentation</b>: A 60-year-old woman was diagnosed with multiple DAVFs with deep venous reflux to evaluate consciousness disturbance. We performed packing of the left transverse sinus, which was chiefly involved in reflux to the straight sinus. However, consciousness continued to be mildly disturbed, and DSA was performed again. A shunt was inserted into the left SPS, and the subsequently occurring deep venous reflux was clearly revealed. Because the ipsilateral transverse sinus and both inferior petrosal sinuses were already occluded and unavailable as access routes, we used the contralateral SPS and both cavernous sinuses to navigate the microcatheter into the shunt. We achieved occlusion of the SPS and stopped the reflux by inserting the intermediate catheter firmly into the bilateral SPS.</p><p><b>Conclusion</b>: An access route through the contralateral SPS might successfully enable transvenous embolization of DAVF cases without an ipsilateral access route.</p>

    DOI: 10.20626/nkc.tn.2021-0009

    CiNii Research

  42. Corpus Callosum Swelling after Resection of Intraventricular Central Neurocytoma.

    Aburakawa D, Kanamori M, Akashi T, Sato S, Saito R, Tominaga T

    NMC case report journal   Vol. 8 ( 1 ) page: 535 - 543   2021

     More details

    Language:English  

    DOI: 10.2176/nmccrj.cr.2020-0369

    PubMed

  43. Atypical Incomplete Detachment Following PulseRider Deployment

    Goto Shunsaku, Izumi Takashi, Nishihori Masahiro, Araki Yoshio, Yokoyama Kinya, Uda Kenji, Saito Ryuta

    Journal of Neuroendovascular Therapy   Vol. advpub ( 0 )   2021

     More details

    Language:English   Publisher:The Japanese Society for Neuroendovascular Therapy  

    <p><b>Objective</b>: Owing to the limited time since the introduction of the PulseRider (PR), inconsequential or rare complications that clinicians should be aware of remain unreported yet. Here, we report a rare complication of incomplete detachment.</p><p><b>Case Presentation</b>: A 50-year-old male underwent PR-assisted coil embolization for a basilar tip aneurysm. Coiling was completed, and the detachment procedure was performed using a detachment machine; the success signal was observed. The delivery microcatheter was subsequently advanced back up to the proximal markers, and no reapproximation of the proximal markers, which indicates successful detachment, was observed. However, only one of the proximal markers returned to the microcatheter, and incomplete detachment of only one leg was detected. Ultimately, electrical detachment was not possible, and physical separation by tension was achieved.</p><p><b>Conclusion</b>: Our case report presents a rare case of a detachment problem in the PR. The PR could not be detached, although the signal revealed successful detachment. Therefore, careful withdrawal of the delivery wire by checking not only the proximal markers but also the behavior of the entire PR and coil complex is important.</p>

    DOI: 10.5797/jnet.cr.2021-0095

    CiNii Research

  44. Unilateral chronic subdural hematoma due to spontaneous intracranial hypotension: a report of four cases.

    Osada Y, Shibahara I, Nakagawa A, Sakata H, Niizuma K, Saito R, Kanamori M, Fujimura M, Suzuki S, Tominaga T

    British journal of neurosurgery   Vol. 34 ( 6 ) page: 632 - 637   2020.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/02688697.2019.1667482

    PubMed

  45. TERT promoter mutation confers favorable prognosis regardless of 1p/19q status in adult diffuse gliomas with IDH1/2 mutations.

    Arita H, Matsushita Y, Machida R, Yamasaki K, Hata N, Ohno M, Yamaguchi S, Sasayama T, Tanaka S, Higuchi F, Iuchi T, Saito K, Kanamori M, Matsuda KI, Miyake Y, Tamura K, Tamai S, Nakamura T, Uda T, Okita Y, Fukai J, Sakamoto D, Hattori Y, Pareira ES, Hatae R, Ishi Y, Miyakita Y, Tanaka K, Takayanagi S, Otani R, Sakaida T, Kobayashi K, Saito R, Kurozumi K, Shofuda T, Nonaka M, Suzuki H, Shibuya M, Komori T, Sasaki H, Mizoguchi M, Kishima H, Nakada M, Sonoda Y, Tominaga T, Nagane M, Nishikawa R, Kanemura Y, Kuchiba A, Narita Y, Ichimura K

    Acta neuropathologica communications   Vol. 8 ( 1 ) page: 201   2020.11

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-020-01078-2

    PubMed

  46. Frequent Clinical and Radiological Progression of Optic Pathway/Hypothalamic Pilocytic Astrocytoma in Adolescents and Young Adults.

    Shoji T, Kanamori M, Saito R, Watanabe Y, Watanabe M, Fujimura M, Ogawa Y, Sonoda Y, Kumabe T, Kure S, Tominaga T

    Neurologia medico-chirurgica   Vol. 60 ( 6 ) page: 277 - 285   2020.6

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.oa.2019-0208

    PubMed

  47. Regression of Recurrent Spinal Cord High-Grade Glioma After Convection-Enhanced Delivery of Nimustine Hydrochloride: Case Reports and Literature Review.

    Endo T, Inoue T, Sugiyama S, Saito R, Tominaga T

    Operative neurosurgery (Hagerstown, Md.)   Vol. 18 ( 4 ) page: 451 - 459   2020.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/ons/opz172

    PubMed

  48. Experience of Low Dose Perampanel to Add-on in Glioma Patients with Levetiracetam-uncontrollable Epilepsy.

    Chonan M, Saito R, Kanamori M, Osawa SI, Watanabe M, Suzuki H, Nakasato N, Tominaga T

    Neurologia medico-chirurgica   Vol. 60 ( 1 ) page: 37 - 44   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmc.oa.2018-0245

    PubMed

  49. Phase I trial of convection-enhanced delivery of nimustine hydrochloride (ACNU) for brainstem recurrent glioma.

    Neuro-oncology advances   Vol. 2 ( 1 ) page: vdaa033   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/noajnl/vdaa033

    PubMed

  50. <i>TERT</i> promoter mutation associated with multifocal phenotype and poor prognosis in patients with <i>IDH</i> wild-type glioblastoma.

    Kikuchi Z, Shibahara I, Yamaki T, Yoshioka E, Shofuda T, Ohe R, Matsuda KI, Saito R, Kanamori M, Kanemura Y, Kumabe T, Tominaga T, Sonoda Y

    Neuro-oncology advances   Vol. 2 ( 1 ) page: vdaa114   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/noajnl/vdaa114

    PubMed

  51. Cystic Glioblastoma Rupturing into the Ventricle.

    Sato Y, Saito R, Kanamori M, Tominaga T

    NMC case report journal   Vol. 7 ( 1 ) page: 39-41   2020.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2176/nmccrj.cr.2019-0043

    PubMed

  52. A multicenter randomized phase III study for newly diagnosed maximally resected glioblastoma comparing carmustine wafer implantation followed by chemoradiotherapy with temozolomide with chemoradiotherapy alone; Japan Clinical Oncology Group Study JCOG1703 (MACS study).

    Kadota T, Saito R, Kumabe T, Mizusawa J, Katayama H, Sumi M, Igaki H, Kinoshita M, Komori T, Ichimura K, Narita Y, Nishikawa R

    Japanese journal of clinical oncology   Vol. 49 ( 12 ) page: 1172 - 1175   2019.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jjco/hyz169

    PubMed

  53. Coexistence of Intracranial Germ Cell Tumor with Growing Arteriovenous Fistula.

    Ishida T, Endo H, Saito R, Kanamori M, Sato K, Matsumoto Y, Endo T, Fujimura M, Tominaga T

    World neurosurgery   Vol. 127   page: 126 - 130   2019.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2019.04.015

    PubMed

  54. Phase I study of a brain penetrant mutant IDH1 inhibitor DS-1001b in patients with recurrent or progressive IDH1 mutant gliomas.

    Natsume Atsushi, Wakabayashi Toshihiko, Miyakita Yasuji, Narita Yoshitaka, Mineharu Yohei, Arakawa Yoshiki, Yamasaki Fumiyuki, Sugiyama Kazuhiko, Hata Nobuhiro, Muragaki Yoshihiro, Nishikawa Ryo, Shinojima Naoki, Kumabe Toshihiro, Saito Ryuta, Ito Kazumi, Tachibana Masaya, Kakurai Yasuyuki, Nishijima Soichiro, Tsubouchi Hiroshi

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 37 ( 15 ) page: .   2019.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Web of Science

  55. Incidence of initial spinal metastasis in glioblastoma patients and the importance of spinal screening using MRI. Reviewed International journal

    Ichiyo Shibahara, Ryuta Saito, Yoshinari Osada, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Shunji Mugikura, Mika Watanabe, Teiji Tominaga

    Journal of neuro-oncology   Vol. 141 ( 2 ) page: 337 - 345   2019.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    PURPOSE: Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magnetic resonance imaging (Gd-MRI). METHODS: Consecutive adult patients with intracranial glioblastoma were treated between 2010 and 2014 and received spinal screening using Gd-MRI. Spinal screening was performed regardless of spine-related symptoms, and patients presenting with and without initial spinal metastasis (spinal and non-spinal groups, respectively) were compared based on patient demographics, tumor characteristics, radiological and molecular features, and overall survival (OS). RESULTS: During the study period, 116 glioblastoma cases were treated and 87 of these (76%) underwent spinal screening. Among these patients, 11 (13%) were included in the spinal group, and 76 (87%) were included in the non-spinal group. All patients of the spinal group were free of symptoms related to spinal lesions. Compared with the non-spinal group, intracranial lesions of the spinal group presented higher incidences of intracranial dissemination and were located at subventricular zones (P = 0.0012 and 0.020, respectively). MIB-1 labeling index, molecular alterations such as IDH1 mutation, TERT promoter mutation, and immunoreactivity of ATRX and MGMT did not differ between two groups. OS was significantly shorter in the spinal group than in the non-spinal group (P = 0.0054). CONCLUSIONS: This study revealed a relatively high incidence of spinal metastasis. A subset of glioblastoma patients benefited from spinal screening, through which early detection of asymptomatic spinal metastasis was achieved.

    DOI: 10.1007/s11060-018-03036-4

    PubMed

  56. Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors.

    Fukuoka K, Kanemura Y, Shofuda T, Fukushima S, Yamashita S, Narushima D, Kato M, Honda-Kitahara M, Ichikawa H, Kohno T, Sasaki A, Hirato J, Hirose T, Komori T, Satomi K, Yoshida A, Yamasaki K, Nakano Y, Takada A, Nakamura T, Takami H, Matsushita Y, Suzuki T, Nakamura H, Makino K, Sonoda Y, Saito R, Tominaga T, Matsusaka Y, Kobayashi K, Nagane M, Furuta T, Nakada M, Narita Y, Hirose Y, Ohba S, Wada A, Shimizu K, Kurozumi K, Date I, Fukai J, Miyairi Y, Kagawa N, Kawamura A, Yoshida M, Nishida N, Wataya T, Yamaoka M, Tsuyuguchi N, Uda T, Takahashi M, Nakano Y, Akai T, Izumoto S, Nonaka M, Yoshifuji K, Kodama Y, Mano M, Ozawa T, Ramaswamy V, Taylor MD, Ushijima T, Shibui S, Yamasaki M, Arai H, Sakamoto H, Nishikawa R, Ichimura K, Japan Pediatric Molecular Neuro-Oncology Group (JPMNG).

    Acta neuropathologica communications   Vol. 6 ( 1 ) page: 134   2018.12

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40478-018-0630-1

    PubMed

  57. SMART (stroke-like migraine attacks after radiation therapy) syndrome responded to steroid pulse therapy: Report of a case and review of the literature. Reviewed International journal

    Wenting Jia, Ryuta Saito, Masayuki Kanamori, Naoya Iwabuchi, Masaki Iwasaki, Teiji Tominaga

    eNeurologicalSci   Vol. 12   page: 1 - 4   2018.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    This report presents a case of stroke-like migraine attacks after radiation therapy (SMART) syndrome in a 31-year-old man in whom symptoms and radiological findings resolved with steroid pulsed therapy and reviews the literatures with special emphasis on the use of steroids against SMART syndrome. The patient had a past history of left temporal anaplastic astrocytoma and was treated with surgery followed by local 72 Gy radiation therapy and chemotherapy using Nimustine Hydrochloride. Four years after the surgery, he was suffering from subacute progressing symptoms of headache, right hemianopia, right hemiparesis and aphasia from 2 to 4 days before admission to our hospital. At first he was diagnosed as symptomatic epilepsy but after extensive examination, the final diagnosis was SMART syndrome. His symptoms soon improved with steroid pulse therapy. In the literature, steroid pulse therapy is not necessarily a standard of care for SMART syndrome, but it seemed to decrease the need of biopsy. As the lesions of SMART syndrome require differential diagnosis from recurrences, biopsy was performed in some cases. However, lack of benefit and possible detriment is reported with biopsy of SMART lesions. Through this experience we suggest that steroid pulse therapy may provide speedy recovery from symptoms, and it should be considered before other invasive investigations or treatments.

    DOI: 10.1016/j.ensci.2018.05.003

    PubMed

  58. Indications for salvage surgery during treatment for intracranial germ cell tumors. Reviewed International journal

    Masayuki Kanamori, Toshihiro Kumabe, Mika Watanabe, Masashi Chonan, Ryuta Saito, Yoji Yamashita, Yoshikazu Ogawa, Yukihiko Sonoda, Teiji Tominaga

    Journal of neuro-oncology   Vol. 138 ( 3 ) page: 601 - 607   2018.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuvant treatment before salvage surgery into increase (growing group, five cases), no change (stable group, seven cases), and decrease (shrinkage group, eight cases) in tumor size. Changes in tumor markers, histological findings, and the pattern of failure after salvage surgery were reviewed. Growing teratoma syndrome (GTS) is defined as enlargement of tumor consisting of mature teratoma after chemotherapy with normalization of tumor markers. In growing group, two cases presented GTS, whereas other three cases did not fulfill the criteria for GTS. All cases in stable and shrinkage group had elevated levels of tumor markers at presentation and decreased levels after neoadjuvant treatment. Histologically, sparse components of mature teratoma with extensive fibrosis were found in cases with GTS and seven of eight cases in shrinkage group, whereas mature teratoma without fibrosis was found in six of seven cases in stable group. Six cases recurred after salvage surgery. We identified three factors as risks for recurrence after salvage surgery, as follows: (1) growing lesion which did not fulfill the criteria for GTS, (2) non-normalized level of tumor marker before salvage surgery, and (3) residual germinoma component. In conclusion, salvage surgery is recommended for patients with GTS, or with normalized tumor markers in stable or shrinkage group.

    DOI: 10.1007/s11060-018-2827-3

    PubMed

  59. [A Case of Ventriculoperitoneal Shunt Dysfunction in an Adult Secondary to Constipation]. Reviewed

    Nakamura L, Saito R, Kanamori M, Morita T, Tashiro R, Tominaga T

    No shinkei geka. Neurological surgery   Vol. 46 ( 5 ) page: 385 - 389   2018.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    INTRODUCTION: Ventriculoperitoneal(VP)shunts function because of the pressure differential between the intracranial space and the peritoneal cavity. Although chronic constipation is often a cause of VP shunt dysfunction in children, it is not well recognized in adults. We present a case of shunt dysfunction that not only resolved after resolution of constipation but also resulted in overdrainage. CASE REPORT: A 28-year-old woman who had a VP shunt placed 11 years prior for hydrocephalus was referred to our department because of an enlarged ventricle diagnosed with computed tomography(CT). She had a previous history of pineal germinoma and a VP shunt was placed to treat the associated hydrocephalus. At presentation, she complained of headache and somnolence. Shunt dysfunction was suspected, but no problem was detected in the shunt system, including pressure settings. As constipation was detected, we treated this condition. Soon after, her symptoms resolved and ventricle size normalized. She was discharged without any deficit, but overdrainage was detected with CT obtained 1 month later. CONCLUSION: Although constipation is not a common cause of shunt dysfunction in adult patients, it is important to consider to avoid unnecessary shunt revision. In the present case, resolution of chronic constipation resulted in resolution of shunt dysfunction. This suggests the importance of resolution of constipation in case of shunt adjustment, even in adult cases.

    DOI: 10.11477/mf.1436203739

    PubMed

  60. Clinical Features of Precocious, Synchronous, and Metachronous Brain Metastases and the Role of Tumor Resection. Reviewed International journal

    Ichiyo Shibahara, Masayuki Kanamori, Takashi Watanabe, Akihiro Utsunomiya, Hiroyoshi Suzuki, Ryuta Saito, Yukihiko Sonoda, Hidefumi Jokura, Hiroshi Uenohara, Teiji Tominaga

    World neurosurgery   Vol. 113   page: e1 - e9   2018.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: The purpose of this study was to clarify clinical features, outcomes, and the role of tumor resection in precocious, synchronous, and metachronous brain metastases. METHODS: Brain metastases were found before primary cancer detection in the precocious group, within 2 months after primary cancer detection in the synchronous group, and 2 months or later after primary cancer detection in the metachronous group. RESULTS: Of 471 patients with brain metastases, 93 (20%) were included in the precocious group, 76 (16%) in the synchronous group, and 302 (64%) in the metachronous group. The precocious group tended to be symptomatic, show a low Karnofsky Performance Status, and have a large single tumor, infrequent extracranial metastases, and frequent tumor resection compared with the other 2 groups. There were no differences in overall survival from the detection of brain metastases among the 3 groups in univariate and multivariate analyses. Of 471 cases, 97 (21%) underwent surgeries. Among this surgical cohort, overall survival from surgery was significantly shorter in the precocious group than in the metachronous group (P = 0.039). After adjustment for age, sex, tumor size, primary cancer, and the Graded Prognostic Assessment score, the hazard ratio for metachronous metastases was 0.52 (confidence interval, 0.29-0.95; P = 0.035). CONCLUSIONS: The timing of brain metastasis diagnosis is not a modifiable factor but affects patient demographics and treatment strategies. In particular, the precocious group is a unique subset of brain metastases that require special consideration during clinical decision making.

    DOI: 10.1016/j.wneu.2017.10.145

    PubMed

  61. [Results for Treatment of Newly-Diagnosed Glioblastoma Using Carmustine Wafers(Gliadel<sup>®</sup>)]. Reviewed

    Kumabe T, Shibahara I, Saito R

    No shinkei geka. Neurological surgery   Vol. 46 ( 5 ) page: 367 - 376   2018.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.11477/mf.1436203736

    PubMed

  62. Rapid detection of mutation in isocitrate dehydrogenase 1 and 2 genes using mass spectrometry. Reviewed

    Masayuki Kanamori, Masamitsu Maekawa, Ichiyo Shibahara, Ryuta Saito, Masashi Chonan, Miki Shimada, Yukihiko Sonoda, Toshihiro Kumabe, Mika Watanabe, Nariyasu Mano, Teiji Tominaga

    Brain tumor pathology   Vol. 35 ( 2 ) page: 90 - 96   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    The 2016 World Health Organization classification of tumors of the central nervous system was recently revised. Mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes and chromosome 1p/19q codeletion are especially important for both the integrated diagnosis and the determination of surgical strategy. To establish a method for intraoperative molecular diagnosis, a simple, rapid method was developed for the measurement of 2-hydroxyglutarate (2-HG), a specific oncometabolite formed in the presence of IDH gene mutation, using liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS). This method requires only 10 min to measure the level of 2-HG from tissue preparation to completion of examination. Using this method, the level of 2-HG was analyzed in 105 patients with diffuse infiltrating glioma, and showed that IDH mutated glioma had significantly higher level of 2-HG compared to IDH wild-type glioma. Receiver operating characteristic curve analysis showed the area under the curve, sensitivity, and specificity were 0.9815, 97.5, and 100%, respectively. In contrast, tumor grade and presence of chromosome 1p/19q codeletion in the IDH mutated glioma could not be predicted from the level of 2-HG. Measurement of 2-HG level using LC/ESI-MS/MS can provide rapid and accurate information of mutation status in the IDH gene.

    DOI: 10.1007/s10014-018-0317-0

    PubMed

  63. Three case reports of radiation-induced glioblastoma after complete remission of acute lymphoblastic leukemia. Reviewed

    Kajitani T, Kanamori M, Saito R, Watanabe Y, Suzuki H, Watanabe M, Kure S, Tominaga T

    Brain tumor pathology   Vol. 35 ( 2 ) page: 114 - 122   2018.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10014-018-0316-1

    PubMed

  64. Convection-enhanced delivery of sulfasalazine prolongs survival in a glioma stem cell brain tumor model. Reviewed International journal

    Shinya Haryu, Ryuta Saito, Wenting Jia, Takuhiro Shoji, Yui Mano, Aya Sato, Masayuki Kanamori, Yukihiko Sonoda, Oltea Sampetrean, Hideyuki Saya, Teiji Tominaga

    Journal of neuro-oncology   Vol. 136 ( 1 ) page: 23 - 31   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Expression of CD44 in glioma cells was previously correlated with tumor grade and is considered a stem cell marker. CD44 stabilizes the cystine-glutamate transporter (xCT) and inhibits apoptosis in cancer stem cells (CSCs). Recently it was found that Sulfasalazine (SSZ), an anti-inflammatory drug, acts as an inhibitor of xCT and therefore has potential as a targeted therapy for CSCs. In this study, we tested an efficacy of SSZ against glioma stem cell model developed in rats. As poor penetration of blood-brain barrier resulted in insufficient efficacy of systemic SSZ treatment, SSZ was delivered locally with convection-enhanced delivery (CED). In vitro, expression of CD44 in glioma cells and efficacy of SSZ against glioma cells and glioma stem cells were confirmed. SSZ demonstrated anti-proliferative activity in a dose dependent manner against these cells. This activity was partially reversible with the addition of antioxidant, N-acetyl-L-cysteine, to the medium. In vivo, CED successfully delivered SSZ into the rat brain parenchyma. When delivered at 5 mM concentration, which was the highest possible concentration when SSZ was dissolved in water, CED of SSZ resulted in almost no tissue damage. Against highly malignant bRiTs-G3 brain tumor xenografted rat model; the glioma stem cell model, CED of SSZ at 5 mM concentration induced apoptosis and prolonged survival. Consequently, CED of SSZ induced glioma stem cell death without evidence of tissue damage to normal brain parenchyma. This strategy may be a promising targeted treatment against glioma stem cells.

    DOI: 10.1007/s11060-017-2621-7

    PubMed

  65. Fingolimod-associated PML with mild IRIS in MS: A clinicopathologic study. Reviewed International journal

    Shuhei Nishiyama, Tatsuro Misu, Yukiko Shishido-Hara, Kazuo Nakamichi, Masayuki Saijo, Yoshiki Takai, Kentarou Takei, Naoki Yamamoto, Hiroshi Kuroda, Ryuta Saito, Mika Watanabe, Teiji Tominaga, Ichiro Nakashima, Kazuo Fujihara, Masashi Aoki

    Neurology(R) neuroimmunology & neuroinflammation   Vol. 5 ( 1 ) page: e415   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Objective: To clarify the clinical, neuropathologic, and virologic characteristics of progressive multifocal leukoencephalopathy (PML) and its immune reconstitution inflammatory syndrome (IRIS) in a patient with fingolimod-treated MS. Methods: A case study. Results: A 34-year-old patient with MS using fingolimod for 4 years had a gradual progression of right hemiparesis and aphasia with a new subcortical white matter lesion in the precentral gyrus by initial MRI. Blood tests were normal, except for lymphopenia (160 cells/μL). One month after the cessation of fingolimod, brain MRI depicted a diffusely exacerbated hyperintensity on fluid-attenuated inversion recovery and diffusion-weighed imaging in the white matter with punctate gadolinium enhancement, suggesting PML-IRIS. A very low level of JC virus (JCV)-DNA (15 copies/mL) was detected in the CSF as judged by quantitative PCR. Brain tissues were biopsied from the left frontal lesion, which showed some small demyelinated foci with predominant loss of myelin-associated glycoprotein with infiltrations of lymphocytes and macrophages, but clear viral inclusion was not observed with hematoxylin-eosin staining. JCV-DNA was uniquely detectable in an active inflammatory demyelinating lesion by in situ hybridization, possibly suggesting an early phase of PML. DNA extracted from the brain sample was positive for JCV-DNA (151 copies/cell). It took 3 months to normalize the blood lymphocyte count. The patient was treated with 1 g of IV methylprednisolone for 3 days and a weekly oral dose (375 mg) of mefloquine, and her symptoms gradually improved. Conclusion: Low CSF JCV-DNA and unfound viral inclusions initially made her diagnosis difficult. The clinical course of fingolimod-associated PML may be associated with mild immune reconstitution.

    DOI: 10.1212/NXI.0000000000000415

    PubMed

  66. Glioblastoma in neurofibromatosis 1 patients without IDH1, BRAF V600E, and TERT promoter mutations. Reviewed

    Ichiyo Shibahara, Yukihiko Sonoda, Hiroyoshi Suzuki, Akifumi Mayama, Masayuki Kanamori, Ryuta Saito, Yasuhiro Suzuki, Shoji Mashiyama, Hiroshi Uenohara, Mika Watanabe, Toshihiro Kumabe, Teiji Tominaga

    Brain tumor pathology   Vol. 35 ( 1 ) page: 10 - 18   2018.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Pilocytic astrocytomas and low-grade gliomas are more common compared with glioblastomas in patients with neurofibromatosis 1 (NF1). A recent genome-wide analysis has shown frequent NF1 gene alterations in the mesenchymal subtype of a glioblastoma; however, little is known about clinicopathological features of glioblastomas in NF1 patients (NF1 glioblastomas). We analyzed four NF1 glioblastomas. Radiographical and intraoperative findings showed well-circumscribed tumors from surrounding brain. Pathological analysis presented a paucity of processes with an eosinophilic cytoplasm, bizarre nuclei, xanthomatous-like appearance, multinucleated giant cells, and histiocytoid appearance. During the follow-up period, one patient died at 49 months and others remained alive for 60, 87, and 106 months; thus, patients with NF1 glioblastoma presented a relatively favorable survival. None of the NF1 glioblastomas harbored isocitrate dehydrogenase 1 (IDH1) gene mutation, v-RAF murine sarcoma viral oncogene homolog B1 (BRAF) gene mutation, and telomerase reverse transcriptase (TERT) gene promoter mutation. We identified that NF1 glioblastoma is a unique subset of glioblastoma.

    DOI: 10.1007/s10014-017-0302-z

    PubMed

  67. Opening the ventricle during surgery diminishes survival among patients with newly diagnosed glioblastoma treated with carmustine wafers: a multi-center retrospective study Reviewed

    Yukihiko Sonoda, Ichiyo Shibahara, Ken-ichiro Matsuda, Ryuta Saito, Tomoyuki Kawataki, Masaya Oda, Yuichi Sato, Hirokazu Sadahiro, Sadahiro Nomura, Toshio Sasajima, Takaaki Beppu, Masayuki Kanamori, Kaori Sakurada, Toshihiro Kumabe, Teiji Tominaga, Hiroyuki Kinouchi, Hiroaki Shimizu, Kuniaki Ogasawara, Michiyasu Suzuki

    JOURNAL OF NEURO-ONCOLOGY   Vol. 134 ( 1 ) page: 83 - 88   2017.8

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    Carmustine wafers (CW) were approved in Japan for newly diagnosed and recurrent malignant gliomas during 2013. The ventricle is often opened during surgery to achieve maximum resection. While not generally recommended in such situations, CW might be safely achieved by occluding an opened ventricle using gelform or collagen sheets. However, whether CW implantation actually confers a survival benefit for patients who undergo surgery with an open ventricle to treat glioblastoma remains unclear. Clinical, imaging, and survival data were collected in this multicenter retrospective study of 122 consecutive patients with newly diagnosed glioblastoma to determine adverse events and efficacy. Overall, 54 adverse events of all grades developed in 35 (28.6%) patients, with the most common being new seizures (16%). Adverse events did not significantly differ between patients with opened and closed ventricles during surgery. The 10- and 21.7-month, median, progression-free (PFS) and overall survival (OS), respectively did not significantly differ according to resection rates. However, median PFS and OS were significantly longer among patients with closed, than open ventricles (12.8 vs. 7.4 months; p = 0.0039 and 26.9 vs. 18.6 months; p = 0.011, respectively). Implanting CW into the resection cavity during concomitant radiochemotherapy with temozolomide seems to yield better survival rates without increased adverse events. Occlusion of the ventricular opening during surgery might be safe for CW implantation, but less so for treating patients with newly diagnosed glioblastoma.

    DOI: 10.1007/s11060-017-2488-7

    Web of Science

    PubMed

  68. Distant recurrences limit the survival of patients with thalamic high-grade gliomas after successful resection Reviewed

    Ryuta Saito, Toshihiro Kumabe, Masayuki Kanamori, Yukihiko Sonoda, Teiji Tominaga

    NEUROSURGICAL REVIEW   Vol. 40 ( 3 ) page: 469 - 477   2017.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    The indications of surgery for thalamic high-grade gliomas are not well established. The present study investigated the outcome of 21 patients treated by surgery and reports the high incidence of distant recurrences including disseminations after successful removal. Twenty-one patients with thalamic high-grade gliomas not invading the pyramidal tract or midbrain underwent cytoreductive surgery at our institute from June 1997 to August 2015. Surgery was performed with the aid of a neuronavigation system, electrophysiological monitoring, and fluorescence navigation. Tumor histology included 12 cases of the World Health Organization grade III and nine cases of grade IV. Gross total resection was achieved in six cases, subtotal in 13, and partial in two. Motor weakness accompanied by sensory disturbance deteriorated immediately after surgery in 13 patients. However, five patients were determined to show deterioration at 2 months after surgery. Postoperative radiation and chemotherapy were given to every patient, and median progression-free survival of patients with grade III and IV tumors was 12.1 and 7.0 months, respectively. Median overall survival of patients with grade III and IV tumors was 25.6 and 12.6 months, respectively. High incidence of distant recurrences was found, with distant lesions at recurrence in 13 of 19 patients with recurrence, suggesting the life-restricting factor in these patients. Thalamic high-grade glioma without invasion into the pyramidal tract and brainstem can be considered as a candidate for surgical resection. Distant lesion limits the survival of patients after successful resection.

    DOI: 10.1007/s10143-016-0804-x

    Web of Science

    PubMed

  69. Convection-enhanced delivery of a hydrophilic nitrosourea ameliorates deficits and suppresses tumor growth in experimental spinal cord glioma models Reviewed

    Shogo Ogita, Toshiki Endo, Shinichiro Sugiyama, Ryuta Saito, Tomoo Inoue, Akira Sumiyoshi, Hiroi Nonaka, Ryuta Kawashima, Yukihiko Sonoda, Teiji Tominaga

    ACTA NEUROCHIRURGICA   Vol. 159 ( 5 ) page: 939 - 946   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER WIEN  

    Convection-enhanced delivery (CED) is a technique allowing local infusion of therapeutic agents into the central nervous system, circumventing the blood-brain or spinal cord barrier.
    To evaluate the utility of nimustine hydrochloride (ACNU) CED in controlling tumor progression in an experimental spinal cord glioma model.
    Toxicity studies were performed in 42 rats following the administration of 4 mu l of ACNU CED into the mid-thoracic spinal cord at concentrations ranging from 0.1 to 10 mg/ml. Behavioral analyses and histological evaluations were performed to assess ACNU toxicity in the spinal cord. A survival study was performed in 32 rats following the implantation of 9 L cells into the T8 spinal cord. Seven days after the implantation, rats were assigned to four groups: ACNU CED (0.25 mg/ml; n = 8); ACNU intravenous (i.v.) (0.4 mg; n = 8); saline CED (n = 8); saline i.v. (n = 8). Hind limb movements were evaluated daily in all rats for 21 days. Tumor sizes were measured histologically.
    The maximum tolerated ACNU concentration was 0.25 mg/ml. Preservation of hind limb motor function and tumor growth suppression was observed in the ACNU CED (0.25 mg/ml) and ACNU i.v. groups. Antitumor effects were more prominent in the ACNU CED group especially in behavioral analyses (P &lt; 0.05; log-rank test).
    ACNU CED had efficacy in controlling tumor growth and preserving neurological function in an experimental spinal cord tumor model. ACNU CED can be a viable treatment option for spinal cord high-grade glioma.

    DOI: 10.1007/s00701-017-3123-2

    Web of Science

    PubMed

  70. Intraoperative Visualization of Subependymal Arteries at the Atrium Supplying the Descending Motor Pathway Reviewed

    Mitsuto Hanihara, Sumito Sato, Ichiyo Shibahara, Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Hiroyuki Kinouchi, Teiji Tominaga, Toshihiro Kumabe

    WORLD NEUROSURGERY   Vol. 101   page: 296 - 303   2017.5

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    OBJECTIVE: We previously disclosed that damage to the subependymal arteries (SEAs) caused by coagulation of the choroid plexus at the atrium can result in infarction within the lateral posterior choroidal artery territory, followed by hemiparesis. The present study describes the intra-operative anatomical findings of the SEAs and choroid plexus at the atrium, which were verified only by a few cadaveric studies.
    METHODS: Locations of the SEA and descending motor pathway were determined with the neuronavigation system and subcortical electrical stimulation in 8 cases of periatrial brain tumor. Indocyanine green videoangiography was performed to verify the blood flowin the choroid plexus and SEAs.
    RESULTS: Intraoperative visualization of the SEAs was performed successfully in all patients. The neuronavigation system and subcortical electrical stimulation mapping demonstrated that these SEAs penetrated into the descending motor pathway. Indocyanine green depicted the blood flow of the SEAs entering the wall of the lateral ventricle and adjacent brain parenchyma. The blood flow directions between the SEAs and choroid plexus were not uniform, because the SEAs were filled ahead of the choroid plexus in 3 cases, whereas the choroid plexus was filled first in the other 2 cases.
    CONCLUSIONS: Manipulations to the inner side of the choroid plexus at the transition from the atrium to the body of lateral ventricle can damage the SEAs. Not only coagulation of the SEAs themselves, but also coagulation of choroid plexus itself may reduce the blood flow in the SEAs, resulting in ischemic complications at descending motor pathway.

    DOI: 10.1016/j.wneu.2017.02.022

    Web of Science

    PubMed

  71. Convection-enhanced Delivery of Therapeutics for Malignant Gliomas Reviewed

    Ryuta Saito, Teiji Tominaga

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 57 ( 1 ) page: 8 - 16   2017.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN NEUROSURGICAL SOC  

    Convection-enhanced delivery (CED) circumvents the blood-brain barrier by delivering agents directly into the tumor and surrounding parenchyma. CED can achieve large volumes of distribution by continuous positive-pressure infusion. Although promising as an effective drug delivery method in concept, the administration of therapeutic agents via CED is not without challenges. Limitations of distribution remain a problem in large brains, such as those of humans. Accurate and consistent delivery of an agent is another challenge associated with CED. Similar to the difficulties caused by immunosuppressive environments associated with gliomas, there are several mechanisms that make effective local drug distribution difficult in malignant gliomas. In this review, methods for local drug application targeting gliomas are discussed with special emphasis on CED. Although early clinical trials have failed to demonstrate the efficacy of CED against gliomas, CED potentially can be a platform for translating the molecular understanding of glioblastomas achieved in the laboratory into effective clinical treatments. Several clinical studies using CED of chemotherapeutic agents are ongoing. Successful delivery of effective agents should prove the efficacy of CED in the near future.

    DOI: 10.2176/nmc.ra.2016-0071

    Web of Science

    PubMed

  72. Extremely Late Recurrence 21 Years after Total Removal of Immature Teratoma: A Case Report and Literature Review Reviewed

    Yui Mano, Masayuki Kanamori, Toshihiro Kumabe, Ryuta Saito, Mika Watanabe, Yukihiko Sonoda, Teiji Tominaga

    NEUROLOGIA MEDICO-CHIRURGICA   Vol. 57 ( 1 ) page: 51 - 56   2017.1

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN NEUROSURGICAL SOC  

    Immature teratoma (IMT) is normally treated by resection and adjuvant therapy. The present unusual case of recurrent germinoma occurred 21 years after total resection of pineal IMT. A 3-year-old boy presented with headache, disturbance of consciousness, and Parinaud's syndrome. Magnetic resonance (MR) imaging revealed a pineal mass lesion, and total resection of the tumor was achieved. The histological diagnosis was mature teratoma. He did not receive further treatment, and did well without recurrence for 20 years. However, he suffered headache 21 years after resection, and MR imaging revealed a homogeneously enhanced pineal mass with low minimum apparent diffusion coefficient value and proton MR spectroscopy showed a huge lipid peak. The levels of tumor markers were not elevated. Cerebrospinal fluid (CSF) cytology found atypical cells with large nuclei and irregularly shaped nucleoli. To elucidate the relationship between the primary and recurrent tumors, we reviewed the histological specimens and CSF cytology at the initial treatment and found a subset of incompletely differentiated components resembling fetal tissues in the histological specimen and atypical large cells in the CSF. Based on these radiological and histological findings, we presume that the recurrent disease was disseminated germinoma after the resection of disseminated IMT. He received chemotherapy and craniospinal radiation therapy, and the enhanced lesion and atypical cells in the CSF disappeared. This case demonstrates that disseminated IMT can be controlled for the long term without adjuvant therapy, but may recur as germinoma. Tumor dormancy may account for this unusual course.

    DOI: 10.2176/nmc.cr.2016-0241

    Web of Science

    PubMed

▼display all

MISC 6

  1. Medical Management of a Mural Thrombus Inducing Repeated Ischemic Strokes in a Patient with Congenital Afibrinogenemia.

    Nishihori M, Araki Y, Suzuki N, Tamura S, Hattori M, Izumi T, Goto S, Yokoyama K, Uda K, Matsushita T, Saito R

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association   Vol. 31 ( 7 ) page: 106526   2022.4

     More details

    Language:English   Publisher:Journal of Stroke and Cerebrovascular Diseases  

    Objectives: Congenital afibrinogenemia is an autosomal recessive inherited disorder that can cause thrombotic as well as hemorrhagic events. We describe a case of repeated mild ischemic strokes due to a mural thrombus in the carotid artery and our medical treatment. Case description: A 49-year-old woman with congenital afibrinogenemia developed two minor ischemic strokes in two months. Clinical images revealed scattered fresh infarcts in the right middle cerebral artery region and mild cervical carotid artery stenosis. The risk for surgical treatment was considered to be extraordinarily high. The patient was treated with 100 mg/day of aspirin and 3 g fibrinogen infusion every two weeks. After the one-year course of medication, the mural thrombus gradually decreased, and there were no bleeding or ischemic stroke events. Conclusion: This case report highlights the successful treatment of an ischemic stroke in a patient with a congenital afibrinogenemia with an antiplatelet agent and fibrinogen replacement. There are no guidelines for managing ischemic stroke in patients with congenital afibrinogenemia, and further studies are needed.

    DOI: 10.1016/j.jstrokecerebrovasdis.2022.106526

    Scopus

    PubMed

  2. Atypical radiographic case of arachnoid web without scalpel sign.

    Nagashima Y, Nishimura Y, Ito H, Oyama T, Nishii T, Gonda T, Kato H, Saito R

    Surgical neurology international   Vol. 13   page: 108   2022

     More details

    Language:English   Publisher:Surgical Neurology International  

    Background: Spinal arachnoid webs (SAW) occur when abnormally thickened bands of arachnoid membranes commonly located dorsal to the thoracic spine cause blockage of normal cerebrospinal fluid (CSF) flow, resulting in focal cord compression and myelopathy. The pathognomonic MR finding for SAW is the "positive scalpel sign"comprised of an enlarged dorsal CSF space with a normal ventral subarachnoid space. The main differential diagnostic consideration for SAW is idiopathic spinal cord herniation (ISCH); however, for ISCH, MR studies classically demonstrate ventral displacement of the spinal cord through an anterior dural defect. Here, we describe a 60-year-old female with an atypical SAW at the T3-T4 level (i.e., the preoperative MR failed to demonstrate the "positive scalpel sign"). Nevertheless, at surgery, intraoperative ultrasonography confirmed that SAW was present and was decompressed/marsupialized/removed. Case Description: A 60-year-old female presented with sensory impairment to both lower extremities. The thoracic MR images showed an enlarged dorsal CSF space at the T3-T4 level but without the "scalpel sign"suggesting "interruption"of CSF flow by thickened bands of focal dorsal arachnoidal tissues. Although the initial preoperative diagnosis was ISCH, intraoperative ultrasound (IOUS) confirmed the presence of a thickened arachnoid band, confirming the diagnosis of a SAW that was appropriately decompressed/resected. Conclusion: Correctly, establishing the preoperative diagnosis of a SAW based on MR imaging may sometimes be difficult as the typical "scalpel sign"may not be present in all patients. Notably, in cases like this one, IOUS may critically confirm the diagnosis of SAW thus leading to appropriate SAW decompression/removal.

    DOI: 10.25259/SNI_179_2022

    Scopus

    PubMed

  3. Two cases of solitary fibrous tumor/hemangiopericytoma with different clinical features according to the World Health Organization classification: case report and review of the literature.

    Nishii T, Nagashima Y, Nishimura Y, Ito H, Oyama T, Matsuo M, Sakakibara A, Shimada S, Saito R

    Journal of spine surgery (Hong Kong)   Vol. 7 ( 4 ) page: 532 - 539   2021.12

     More details

    Language:English   Publisher:Journal of Spine Surgery  

    Solitary fibrous tumors (SFTs) and hemangiopericytomas (HPCs) have been classified as one entity by the World Health Organization in 2016 due to gene fusion between NAB2 and STAT6. In the Central Nervous System (CNS), a hypocellular, collagenized tumor with a classic SFT phenotype is considered grade I, whereas more densely cellular tumors mostly corresponding to the HPC phenotype are classified as grade II or III (anaplastic) depending in mitotic count (<5 vs. >5 mitoses per 10 high-power fields). Herein, we report two cases of targeted SFT/HPC in which pathological differences and WHO grading affect clinical features. A 75-year-old woman presented with headache and had an intradural extramedullary tumor at the C1 to C2 level. The tumor was well-circumscribed and attached only to the dura mater. It was totally removed and diagnosed SFT/HPC grade I. In contrast, a 68-year-old woman presented with numbness in the right upper limb and had an intradural extramedullary tumor at the medulla to C3 levels The tumor was irregularly marginated and strongly adherent to the spinal cord and involved the vertebral artery. It was sub totally removed and diagnosed SFT/HPC grade II. To the best of our knowledge, there are only 12 cases of SFT/HPC at the craniocervical junction, including the present two cases, of which four that were adherent to the spinal cord or involved the vertebral artery were grade II or III. Although the location of the tumor was almost the same, there were significant differences in the intraoperative findings according to the WHO grading.

    DOI: 10.21037/jss-21-83

    Scopus

    PubMed

  4. Management of Asymptomatic Vertebral Artery Injury Caused by a Cervical Pedicle Screw Malposition: Two Case Reports

    OTSUKA Takafumi, IZUMI Takashi, NISHIHORI Masahiro, TSUKADA Tetsuya, ARAKI Yoshio, YOKOYAMA Kinya, UDA Kenji, GOTO Shunsaku, IKEZAWA Mizuka, KATO Naoki, NAKANO Mizuki, SAITO Ryuta

    NMC Case Report Journal   Vol. 8 ( 1 ) page: 713 - 717   2021

     More details

    Language:English   Publisher:The Japan Neurosurgical Society  

    <p>Iatrogenic vertebral artery (VA) injury in cervical fusion is an extremely rare complication but can lead to serious sequelae. We present two successful cases of internal trapping for preventing delayed-onset ischemic stroke after iatrogenic VA stenosis caused by a cervical pedicle screw. A 34-year-old female underwent posterior cervical fusion for C4/C5 dislocation fracture. No neurological deficits were observed after the operation. However, the postoperative images revealed that the left C5 pedicle screw perforated the transverse foramen, and the left VA was suspected to be occluded at the screw insertion site. Before revision surgery, we tried to embolize the injured VA with coils. A microcatheter could be navigated from the ipsilateral VA to the distal of the screw, and internal trapping was performed with coils. Another case is that of a 50-year-old male with cervical spondylosis, who underwent posterior decompression and cervical fusion. The neurological symptoms did not deteriorate after the operation. However, the postoperative computed tomography images revealed the perforation of the right C3 transverse foramen by the pedicle screw. In right vertebral angiography, about 70% stenosis was observed at the screw insertion site. Although revision surgery was not planned due to good stability, we embolized the right VA after balloon occlusion test, to prevent the delayed-onset thromboembolic complications. Both the patients recovered without any neurological deficits. Iatrogenic VA injuries, even if asymptomatic immediately after surgery, can lead to serious sequelae in case of delayed-onset ischemic stroke. Therefore, careful attention should be paid when the screw perforates the transverse foramen.</p>

    DOI: 10.2176/nmccrj.cr.2021-0062

    PubMed

    CiNii Research

  5. Survival Benefit of Supratotal Resection in a Long-term Survivor of <i>IDH</i>-wildtype Glioblastoma: A Case Report and Literature Review

    YAMAGUCHI Junya, MOTOMURA Kazuya, OHKA Fumiharu, AOKI Kosuke, TANAHASHI Kuniaki, HIRANO Masaki, CHALISE Lushun, NISHIKAWA Tomohide, SHIMIZU Hiroyuki, NATSUME Atsushi, WAKABAYASHI Toshihiko, SAITO Ryuta

    NMC Case Report Journal   Vol. 8 ( 1 ) page: 747 - 753   2021

     More details

    Language:English   Publisher:The Japan Neurosurgical Society  

    <p>Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3–5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. Magnetic resonance imaging (MRI) revealed a heterogeneous gadolinium-enhancing lesion in the left inferior parietal lobule. The patient underwent awake surgery, and tumor resection included abnormalities on T2-weighted MRI, with subcortical mapping used to identify the deep functional boundaries. After supratotal resection, the tumor was diagnosed as GBM without isocitrate dehydrogenase (<i>IDH</i>) 1 and 2 mutations. At a follow-up evaluation, 9 years and 2 months after the surgery, the patient appeared healthy, and no relapse or recurrence was observed. We present the case of a long-term survivor of <i>IDH</i>-wildtype GBM. This case suggests that supratotal resection with intraoperative awake brain mapping can improve survival without impairing the patient’s neurological functions.</p>

    DOI: 10.2176/nmccrj.cr.2021-0120

    PubMed

    CiNii Research

  6. Postoperative Cervicothoracic Kyphosis Following Infantile Intramedullary Tumor Resection Accelerates Neurological Deterioration

    GONDA Tomomi, NAGASHIMA Yoshitaka, NISHIMURA Yusuke, ITO Hiroshi, NISII Tomoya, OYAMA Takahiro, HARA Masahito, SAITO Ryuta

    NMC Case Report Journal   Vol. 8 ( 1 ) page: 705 - 711   2021

     More details

    Language:English   Publisher:The Japan Neurosurgical Society  

    <p>Intramedullary spinal cord tumors are rare in children. Regardless of the type of tumor, surgical removal is thought to improve progression-free survival. However, postoperative kyphosis is a serious problem in children, who can expect long-term survival. We present a pediatric case of neurofibromatosis type 2-related spinal ependymoma at the cervicothoracic regions where acute neurological deterioration was developed due to a combination of tumor recurrence and postoperative kyphotic deformity. In the first surgery, subtotal tumor resection was performed via osteoplastic laminotomy. Postoperative radiological evaluation at several months showed cervicothoracic junctional kyphosis, which subsequently made a significant improvement by lifestyle instructions. However, 22 months after the surgery, he exhibited rapid neurological deterioration caused by the regrowth of the recurrent tumor and re-emergence of kyphotic deformity, which led to the fixed laminar flap sank into the spinal canal. Therefore, a second surgery was performed 23 months after the first surgery, and gross total removal was achieved. Osteoplastic laminotomy is presumed to reduce the occurrence of postoperative kyphosis compared with laminectomy, but there have been no reports on the spinal cord compression by plunging of the re-fixed laminar flap into the spinal canal. The kyphosis deformity increases the chance of re-fixed laminar flap coming off, thereby accelerating neurological injury on top of the neural damage by tumor recurrence itself. Therefore, pediatric patients with spinal cord tumors should be carefully managed in terms of recurrent tumors and postoperative kyphosis, and timely surgical intervention is necessary before kyphotic deformity becomes evident.</p>

    DOI: 10.2176/nmccrj.cr.2021-0086

    PubMed

    CiNii Research

▼display all

Presentations 32

  1. 悪性グリオーマの最新治療とprecision medicineの未来

    齋藤竜太

    第42回日本脳神経外科コングレス  2022.5.13  日本脳神経外科コングレス

     More details

    Event date: 2022.5

    Language:English   Presentation type:Symposium, workshop panel (nominated)  

  2. 摘出度を適格規準として術中ランダム化を行う膠芽腫に対する比較臨床試験

    齋藤竜太、木下 学、山崎文之、角 美奈子、井垣 浩、渋谷 誠、佐々木 惇、小森隆司、荒川芳輝、成田善孝、西川亮、関野雄太、佐々木啓太、隈部俊宏

    第39回日本脳腫瘍学会学術集会  2021.12.5  日本脳腫瘍学会

     More details

    Event date: 2021.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:兵庫  

  3. 薬剤局所投与による脳腫瘍新規治療法の開発 Invited

    齋藤竜太

    第1回東海北陸脳腫瘍セミナー  2021.11.29 

     More details

    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  4. 脳腫瘍治療成績向上に向けた取り組みの現状

    齋藤竜太

    第24回日本臨床脳神経外科学会学術集会  2021.11.12  日本臨床脳神経外科学会

     More details

    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:沖縄  

  5. Visualization of drug delivery in local convection-enhanced delivery against brain tumors Invited

    2021.10.30 

     More details

    Event date: 2021.10

    Language:English  

  6. 脳腫瘍治療成績向上を目指して:摘出術を中心に Invited

    齋藤竜太

    第80回日本脳神経外科学会学術集会  2021.10.29  日本脳神経外科学会

     More details

    Event date: 2021.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:横浜  

  7. 脳幹グリオーマに対するConvection-enhanced deliveryを用いた局所化学療法

    齋藤竜太

    第80回日本脳神経外科学会学術集会  2021.10.27  日本脳神経外科学会

     More details

    Event date: 2021.10

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:横浜  

  8. グリオーマ治療の現状と近未来 Invited

    齋藤竜太

    第100回日本脳神経外科学会中部支部学術集会  2021.9.18  日本脳神経外科学会中部支部

     More details

    Event date: 2021.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋  

  9. 画像誘導下脳腫瘍局所治療

    齋藤竜太

    2021.5.15  日本脳神経外科コングレス

     More details

    Event date: 2021.5

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:大阪  

  10. 脳腫瘍に対する局所化学療法 Invited

    齋藤竜太

    第30回脳神経外科手術と機器学会  2021.4.24  日本脳神経外科手術と機器学会

     More details

    Event date: 2021.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:札幌  

  11. 脳腫瘍の局所治療 Invited

    齋藤竜太

    第99回日本脳神経外科学会中部支部学術集会  2021.4.3  日本脳神経外科学会中部支部

     More details

    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:金沢  

  12. 悪性神経膠腫治療成績向上を目指して Invited

    齋藤竜太

    ニューロオンコロジーセントラル  2021.3.27  NeuroOncology Centeral/中外製薬

     More details

    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:名古屋  

  13. Convection-enhanced delivery of nimustine hydrochloride for malignant glioma.

    Ryuta Saito, Teiji Tominaga

    The Fourth International MASSIN Congress  Madjid Samii Congress of International Neurosurgeons

  14. ACNU as the best nitrosourea for local convection-enhanced delivery: report on pharmacokinetics

    Ryuta Saito, Jia Wenting, Aya Sato, Saori Okuno, Taigen Nakamura, Masashi Chonan, Rong Zhang, Masayuki Kanamori, Teiji Tominaga

    Society for Neuro-oncology  2017 

  15. A Pediatric Case of Left Frontal Hemorrhagic Tumor Radiographically Diagnosed as Leukoencephalopathy with Calcification and Cysts.

    Ryuta Saito, Masayuki Kanamori, Mitsugu Uematsu, Mika Watanabe, Teiji Tominaga

    ICN/BTP2018 (第36回日本脳腫瘍病理学会)  2018  日本脳腫瘍病理学会

  16. Convection-enhanced delivery of Nimustine Hydrochroride against brainstem gliomas.

    Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga

    22th International Conference on Brain Tumor Research and Therapy  2018 

  17. 脳腫瘍関連てんかんに対するフィコンパ投与経験

    Ryuta Saito

    Epilepsy Summit in Sendai  2018 

  18. 脳腫瘍に対するニトロソウレア剤局所投与:ACNUの有用性に関する基礎的研究

    Ryuta Saito, Jia Wenting, Aya Sato, Saori Okuno, Taigen Nakamura, Masashi Chonan, Rong Zhang, Masayuki Kanamori, Teiji Tominaga

    第18回日本分子脳神経外科学会  2017  日本分子脳神経外科学会

  19. 神経膠腫症例における症候性脳梗塞

    Ryuta Saito, Masayuki Kanamori, Masashi Chonan, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga

    第43回日本脳卒中学会学術集会  2018  日本脳卒中学会

  20. 神経膠腫に対する治療戦略 -臨床と研究から-

    Ryuta Saito

    岩手県立病院医学会脳神経外科分科会  2018 

  21. 東北大学脳神経外科における悪性神経膠腫に対するベバシズマブ使用の実際

    Ryuta Saito, Masayuki Kanamori, Masashi Chonan, Yukihiko Sonoda, Teiji Tominaga

    東北地方会  2017  日本脳神経外科学会

  22. 悪性神経膠腫に対する局所化学療法

    Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga

    第37回日本脳神経外科コングレス  2017  日本脳神経外科学会

  23. 悪性神経膠腫における血栓塞栓症

    Ryuta Saito

    東北脳腫瘍研究会  2018 

  24. 小児第4 脳室上衣腫に対する治療戦略

    Ryuta Saito

    第23回日本脳腫瘍の外科学会  2018  日本脳腫瘍の外科学会

  25. 小児びまん性橋神経膠腫に対するConvection-enhanced deliveryを用いた塩酸ニムスチン局所投与:医師主導治験

    Ryuta Saito, Masayuki Kanamori, Aya Sato, Saori Okuno, Teiji Tominaga

    第46回日本小児神経外科学会  2018  日本小児神経外科学会

  26. 初回再発悪性神経膠腫に対する摘出術後塩酸ニムスチンconvection enhanced delivery 投与とテモゾロミド内服?Phase I/II臨床試験?.

    Ryuta Saito

    第32回日本脳腫瘍学会学術集会  日本脳腫瘍学会

  27. Venous thromboembolism in patients with malignant brain tumor: 〜management strategy to avoid mortality〜

    Ryuta Saito

    第39回日本血栓止血学会学術集会  2017  日本血栓止血学会

  28. Use of Bevacizumab against malignant glioma cases at Tohoku University Hospital: Initial experience with 100 cases

    Ryuta Saito, Masayuki Kanamori, Masashi Chonan, Yukihiko Sonoda, Teiji Tominaga

    Asian Society for Neuro-Oncology  2017 

  29. Phase I Trial of a Convection-enhanced Delivery of Nimustine Hydrochloride (ACNU) for Patients With Brainstem Recurrent Glioma

    Ryuta Saito, Yukihiko Sonoda, Masayuki Kanamori, Yoji Yamashita, Kenichi Nagamatsu, Toshihiro Kumabe, Teiji Tominaga

    Society for Neuro-oncology  2017 

  30. Convection-enhanced deliveryによる脳幹腫瘍の治療:医師主導治験に向けて

    Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Yoji Yamashita, Shunji Mugikura, Toshihiro Kumabe, Teiji Tominaga

    日本脳神経外科学会第76回学術総会  2017  日本脳神経外科学会

  31. Convection-enhanced deliveryによる脳幹腫瘍の治療

    Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Yoji Yamashita, Shunji Mugikura, Toshihiro Kumabe, Teiji Tominaga

    第22回日本脳腫瘍の外科学会  2017  日本脳腫瘍の外科学会

  32. Convection-enhanced deliveryによる局所化学療法開発の現状

    Ryuta Saito, Masayuki Kanamori, Yukihiko Sonoda, Shunji Mugikura, Toshihiro Kumabe, Teiji Tominaga

    第35回日本脳腫瘍学会学術集会  2017  日本脳腫瘍学会

▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 9

  1. Research for clinical application of ultrasound facilitated drug delivery system

    Grant number:21H03039  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

      More details

    Authorship:Principal investigator 

    Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )

  2. 超音波併用脳内局所広範囲薬剤投与法を用いた画期的なアルツハイマー病新規治療法開発

    Grant number:20K21641  2020.7 - 2023.3

    科学研究費助成事業  挑戦的研究(萌芽)

    齋藤 竜太

      More details

    Authorship:Principal investigator 

    Grant amount:\6240000 ( Direct Cost: \4800000 、 Indirect Cost:\1440000 )

    アルツハイマー病に関して近年、精力的に研究が進められており、アミロイド蛋白の蓄積を可視化する研究が進められている。この中で、早期におけるアミロイド蛋白の蓄積は全般性ではなく、脳のある部位に特に蓄積が多くなる傾向があることが判明しており、アミロイド蓄積部位の局所治療が功を奏する可能性が示唆される。これまでに脳内広範囲薬剤送達技術によりアミロイド蓄積を低減できる可能性を確認しており、本研究では脳局所のアミロイド沈着を解除する新規治療法の開発を行う。

  3. Development of a weak shock wave pulse jet scalpel that achieves both local control of infiltrating lesions and preservation of postoperative function

    Grant number:18H04157  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Nakagawa Atsuhiro

      More details

    Authorship:Coinvestigator(s) 

    The purpose of present study was to achieve infiltration of drug delivery to brain parenchyma through neuroendoscopic procedure by applying pulsed water jet. We have hypothesized that the penetration depth and area can be modified by applying shock wave. We have measured material property of brain and measured penetration depth and area using brain phantom and animal model. Present results showed the possibility of shock wave modified pulsed water jet can be additional treatment tool for the malignant lesion without well demarcated margin.

  4. 浸潤病変の局所制御と術後機能温存を両立する微弱衝撃波パルスジェットメスの開発

    2018.4 - 2021.3

    文部科学省  科学研究費助成事業 基盤研究(A) 

    中川 敦寛

      More details

    Grant type:Competitive

  5. 希少・難治小児脳幹部神経膠腫に対する塩酸ニムスチン局所投薬による新規治療法開発:多施設共同医師主導治験

    2017.4 - 2020.3

    日本医療研究開発機構(AMED)  臨床研究・治験推進研究事業 

    冨永 悌二

      More details

    Grant type:Competitive

  6. 脳内広範囲薬剤送達技術を用いたChemicalSurgery確立に向けた基礎研究

    2017.4 - 2020.3

    文部科学省  科学研究費助成事業 基盤研究(B) 

    齋藤 竜太

      More details

    Authorship:Principal investigator  Grant type:Competitive

  7. Basic Research for Development of Chemical Surgery

    Grant number:17H04299  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Saito Ryuta

      More details

    Authorship:Principal investigator 

    Grant amount:\17290000 ( Direct Cost: \13300000 、 Indirect Cost:\3990000 )

    Basic research of local convection-enhanced delivery (CED) was performed and following data were acquired. 1)Detection of local distribution and analysis of route of clearance after CED of ACNU. Mass spectrometric analysis demonstrated the robust distribution of ACNU after CED in the brain parenchyma. Radiolabeled ACNU enabled the detection of systemic clearance route after CED. 2)Establishment of MRI detection method to monitor the drug distribution without using contrast enhancing agent. We succeeded to monitor the drug distribution using T2-map based MRI. 3)The effect of pharmaceutical preparation on CED was summarized. The appropriate preparation of ACNU was defined. 4)Aiming at evaluating the effect of ultrasound on brain tissue with our newly developed ultrasound facilitated drug delivery system, acoustic characteristic of the device was analyzed by accumulation of the data measuring the conduction of ultrasound in the water.

  8. 脳内広範囲薬剤送達 システムの開発- 塩酸ニムスチン局所投与による脳腫瘍治療法-

    2016.4 - 2017.3

    文部科学省  橋渡し研究加速ネットワークプログラム研究開発施設共用等促進費補助金 シーズB 

    冨永 悌二

      More details

    Grant type:Competitive

  9. 幹細胞分化誘導薬を用いたCED法による膠芽腫新規治療法の開発

    2014 - 2017

    文部科学省  科学研究費助成事業 基盤研究(C) 

    園田 順彦

      More details

    Grant type:Competitive

▼display all

 

Teaching Experience (On-campus) 2

  1. 医学入門

    2021

     詳細を見る

    医学部1年生に対して
    Human BiologyのSencesを担当した

  2. ポリクリ1

    2020

     詳細を見る

    ポリクリ1で実習に来る全てのグループに対してオリエンテーション、総括を行った。

Teaching Experience (Off-campus) 1

  1. 脳腫瘍

    2021.9 Meijo University)

     More details

    Level:Undergraduate (specialized) 

 

Social Contribution 1

  1. ストップ!NO卒中プロジェクト 支部講演会in愛知

    Role(s):Presenter

    公益社団法人日本脳卒中協会/ファイザー株式会社  2021.11