Updated on 2024/03/20

写真a

 
TSUBOI Takashi
 
Organization
Nagoya University Hospital Center for Postgraduate Clinical Training and Career Development Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. 医学博士 ( 2015.1   名古屋大学 ) 

Research Interests 5

  1. パーキンソン病

  2. 振戦

  3. ジストニア

  4. 脳深部刺激療法

  5. Speech and voice disorders

Research Areas 1

  1. Life Science / Neurology  / Parkinson's disease, tremor, movement disorders, DBS, FUS

Research History 8

  1. Nagoya University   Neurology department & Center for Medical Education   Assistant Professor   MD., PhD.

    2020.12

  2. Nagoya University Hospital   Neurology department   Assistant Professor   MD, PhD

    2020.12

  3. 名古屋大学医学部附属病院 医員

    2020.4

  4. 名古屋大学医学部附属病院   脳神経内科   医員

    2020.4 - 2020.11

  5. フロリダ大学神経内科 研究員

    2018.4 - 2020.3

  6. 名古屋大学医学部附属病院   神経内科   医員

    2015.4 - 2018.3

  7. 名古屋大学大学院医学系研究科 客員研究員

    2014.4 - 2015.3

  8. 安城更生病院 後期研修医

    2007.4 - 2010.3

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Education 2

  1. 名古屋大学大学院医学系研究科

    2010.4 - 2014.3

  2. Nagoya University

    1999.4 - 2005.3

Professional Memberships 4

  1. Movement Disorders Society Japan

  2. Movement Disorders Society

  3. 日本神経学会

  4. 日本内科学会

Committee Memberships 4

  1. Movement Disorders Society   Steering Committee member of Speech Impairment in Movement Disorders Study Group  

    2023.11   

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    Committee type:Academic society

  2. 日本パーキンソン病・運動障害疾患学会   評議員  

    2022.7   

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    Committee type:Academic society

  3. Movement Disorders Society   Awards Committee member  

    2021.8   

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    Committee type:Academic society

  4. Movement Disorders Society Asia Oceania Section   Educational Committee member  

    2021.8   

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    Committee type:Academic society

Awards 6

  1. 2021年度いしがね海老原財団Neuroscience Awards

    2021.9   いしがね海老原財団   脳内ネットワークに着目したパーキンソン病と運動障害疾患の病態解明とQOL向上

    坪井崇

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    Award type:Award from publisher, newspaper, foundation, etc. 

  2. パーキンソン病・運動障害疾患コングレス最優秀賞

    2021.7   Movement Disorders Society Japan   本態性振戦とジストニア性振戦における脳深部刺激療法後の振戦改善効果に関連する脳内ネットワークの相違

    Tsuboi T, Wong JK, Eisinger RS, Okromelidze L, Burns MR, Ramirez-Zamora A, Almeida L, Wagle Shukla A, Foote KD, Okun MS, Grewal SS, Katsuno M, Middlebrooks EH

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    Award type:Award from Japanese society, conference, symposium, etc. 

  3. パーキンソン病・運動障害疾患コングレス最優秀賞

    2021.3   Movement Disorders Society Japan   パーキンソン病における淡蒼球脳深部刺激療法後の刺激誘発性ジスキネジアの病態解析

    Tsuboi T,Elkouzi A, Deeb W, Ramirez-Zamora A, Almeida L, Zeilman PR, Eisinger RS, Foote KD, Okromelidze L, Grewal SS, Okun MS, katsuno M, Middlebrooks EH

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    Award type:Award from Japanese society, conference, symposium, etc. 

  4. パーキンソン病・運動障害疾患コングレス最優秀賞

    2017.10   Movement Disorders Society Japan   パーキンソン病患者の発話機能に対する視床下核脳深部刺激術の影響-縦断的観察研究-

    坪井崇,渡辺宏久,田中康博,大嶽れい子,服部誠,川畑和也,原一洋,中坪大輔,前澤聡,梶田泰一,若林俊彦,勝野雅央,祖父江元

  5. 2017 international PD symposium Best Video Presentation Award

    2017.2   Takamatsu international PD symposium  

  6. The Best Presentation Award

    2015.8   Movement Disorders Society  

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    Award type:Award from international society, conference, symposium, etc. 

    the Basic Scientist Summer School

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Papers 73

  1. Effects of MAO-B inhibitors on non-motor symptoms and quality of life in Parkinson’s disease: A systematic review Reviewed

    Takashi Tsuboi, Yuki Satake, Keita Hiraga, Katsunori Yokoi, Makoto Hattori, Masashi Suzuki, Kazuhiro Hara, Adolfo Ramirez-Zamora, Michael S. Okun, Masahisa Katsuno

    npj Parkinson's Disease   Vol. 8 ( 1 ) page: 75   2022.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41531-022-00339-2

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  2. Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation Reviewed International coauthorship

    Takashi Tsuboi, Joshua K Wong, Robert S Eisinger, Lela Okromelidze, Mathew R Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D Foote, Michael S Okun, Sanjeet S Grewal, Erik H Middlebrooks

    Brain   Vol. 144 ( 6 ) page: 1774 - 1786   2021.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Oxford University Press (OUP)  

    Abstract

    The pathophysiology of dystonic tremor and essential tremor remains partially understood. In patients with medication-refractory dystonic tremor or essential tremor, deep brain stimulation (DBS) targeting the thalamus or posterior subthalamic area has evolved into a promising treatment option. However, the optimal DBS targets for these disorders remains unknown. This retrospective study explored the optimal targets for DBS in essential tremor and dystonic tremor using a combination of volumes of tissue activated estimation and functional and structural connectivity analyses. We included 20 patients with dystonic tremor who underwent unilateral thalamic DBS, along with a matched cohort of 20 patients with essential tremor DBS. Tremor severity was assessed preoperatively and approximately 6 months after DBS implantation using the Fahn-Tolosa-Marin Tremor Rating Scale. The tremor-suppressing effects of DBS were estimated using the percentage improvement in the unilateral tremor-rating scale score contralateral to the side of implantation. The optimal stimulation region, based on the cluster centre of gravity for peak contralateral motor score improvement, for essential tremor was located in the ventral intermediate nucleus region and for dystonic tremor in the ventralis oralis posterior nucleus region along the ventral intermediate nucleus/ventralis oralis posterior nucleus border (4 mm anterior and 3 mm superior to that for essential tremor). Both disorders showed similar functional connectivity patterns: a positive correlation between tremor improvement and involvement of the primary sensorimotor, secondary motor and associative prefrontal regions. Tremor improvement, however, was tightly correlated with the primary sensorimotor regions in essential tremor, whereas in dystonic tremor, the correlation was tighter with the premotor and prefrontal regions. The dentato-rubro-thalamic tract, comprising the decussating and non-decussating fibres, significantly correlated with tremor improvement in both dystonic and essential tremor. In contrast, the pallidothalamic tracts, which primarily project to the ventralis oralis posterior nucleus region, significantly correlated with tremor improvement only in dystonic tremor. Our findings support the hypothesis that the pathophysiology underpinning dystonic tremor involves both the cerebello-thalamo-cortical network and the basal ganglia-thalamo-cortical network. Further our data suggest that the pathophysiology of essential tremor is primarily attributable to the abnormalities within the cerebello-thalamo-cortical network. We conclude that the ventral intermediate nucleus/ventralis oralis posterior nucleus border and ventral intermediate nucleus region may be a reasonable DBS target for patients with medication-refractory dystonic tremor and essential tremor, respectively. Uncovering the pathophysiology of these disorders may in the future aid in further improving DBS outcomes.

    DOI: 10.1093/brain/awab074

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    Other Link: http://academic.oup.com/brain/article-pdf/144/6/1774/39427710/awab074.pdf

  3. Pallidal Connectivity Profiling of Stimulation-Induced Dyskinesia in Parkinson's Disease. Reviewed International coauthorship International journal

    Takashi Tsuboi, Marc Charbel, David T Peterside, Mohit Rana, Ahmad Elkouzi, Wissam Deeb, Adolfo Ramirez-Zamora, Janine Lemos Melo Lobo Jofili Lopes, Leonardo Almeida, Pamela R Zeilman, Robert S Eisinger, Kelly D Foote, Lela Okromelidze, Sanjeet S Grewal, Michael S Okun, Erik H Middlebrooks

    Movement disorders : official journal of the Movement Disorder Society   Vol. 36 ( 2 ) page: 380 - 388   2021.2

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVES: The aim of this study is to identify anatomical regions related to stimulation-induced dyskinesia (SID) after pallidal deep brain stimulation (DBS) in Parkinson's disease (PD) patients and to analyze connectivity associated with SID. METHODS: This retrospective study analyzed the clinical and imaging data of PD patients who experienced SID during the monopolar review after pallidal DBS. We analyzed structural and functional connectivity using normative connectivity data with the volume of tissue activated (VTA) modeling. Each contact was assigned to either that producing SID (SID VTA) or that without SID (non-SID VTA). Structural and functional connectivity was compared between SID and non-SID VTAs. "Optimized VTAs" were also estimated using the DBS settings at 6 months after implantation. RESULTS: Of the 68 consecutive PD patients who underwent pallidal implantation, 20 patients (29%) experienced SID. SID VTAs were located more dorsally and anteriorly compared with non-SID and optimized VTAs and were primarily in the dorsal globus pallidus internus (GPi) and dorsal globus pallidus externus (GPe). SID VTAs showed significantly higher structural connectivity than non-SID VTAs to the associative cortex and supplementary motor area/premotor cortex (P < 0.0001). Simultaneously, non-SID VTAs showed greater connectivity to the primary sensory cortex, cerebellum, subthalamic nucleus, and motor thalamus (all P < 0.0004). Functional connectivity analysis showed significant differences between SID and non-SID VTAs in multiple regions, including the primary motor, premotor, and prefrontal cortices and cerebellum. CONCLUSION: SID VTAs were primarily in the dorsal GPi/GPe. The connectivity difference between the motor-related cortices and subcortical regions may explain the presence and absence of SID. © 2020 International Parkinson and Movement Disorder Society.

    DOI: 10.1002/mds.28324

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  4. Quality of life outcomes after globus pallidus internus deep brain stimulation in idiopathic or inherited isolated dystonia: a meta-analysis. Reviewed International coauthorship International journal

    Takashi Tsuboi, James H Cauraugh, Joshua K Wong, Michael S Okun, Adolfo Ramirez-Zamora

    Journal of neurology, neurosurgery, and psychiatry   Vol. 91 ( 9 ) page: 938 - 944   2020.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:{BMJ}  

    BACKGROUND: Several studies reported the beneficial effects of globus pallidus internus deep brain stimulation (GPi DBS) on health-related quality of life (HRQoL) in patients with inherited or idiopathic isolated dystonia. However, the impact of this intervention on physical and mental/psychological domains and the effects over time remain unclear. METHODS: We conducted a systematic literature review from January 2000 to May 2019 and performed a meta-analysis of HRQoL outcomes based on the Short Form Health Survey-36 (SF-36) after GPi DBS in patients with inherited or idiopathic isolated dystonia to evaluate the effects of DBS on physical and mental QoL. RESULTS: Seven studies comprising 144 patients with dystonia (78, generalised; 34, segmental; and 32, focal cervical) were included in this comprehensive analysis. The mean (SD) age at DBS implantation was 41.0 (11.4) years, and the follow-up period after implantation was 3.2 (3.8) years. The random effects model meta-analysis revealed that both physical and mental domains of SF-36 improved following DBS with a significantly larger effect size for the physical domains (effect size=0.781; p<0.0001) compared with the mental domains (effect size=0.533; p<0.0001). A moderator variable analysis demonstrated that effect sizes for HRQoL improvement were maintained over time. CONCLUSIONS: This is the first meta-analysis that demonstrates significant benefits in HRQoL following DBS in patients with inherited or idiopathic isolated dystonia. The benefits are greater for physical QoL domains compared with mental/psychological QoL. These findings highlight the importance of a comprehensive multidisciplinary approach to improve mental/psychological QoL.

    DOI: 10.1136/jnnp-2019-322575

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  5. Longitudinal follow-up with VIM thalamic deep brain stimulation for dystonic or essential tremor. Reviewed International coauthorship International journal

    Takashi Tsuboi, Zakia Jabarkheel, Pamela R Zeilman, Matthew J Barabas, Kelly D Foote, Michael S Okun, Aparna Wagle Shukla

    Neurology   Vol. 94 ( 10 ) page: e1073-e1084   2020.3

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Ovid Technologies (Wolters Kluwer Health)  

    OBJECTIVE: To assess longitudinal tremor outcomes with ventral intermediate nucleus deep brain stimulation (VIM DBS) in patients with dystonic tremor (DT) and to compare with DBS outcomes in essential tremor (ET). METHODS: We retrospectively investigated VIM DBS outcomes for 163 patients followed at our center diagnosed with either DT or ET. The Fahn-Tolosa-Marin tremor rating scale (TRS) was used to assess change in tremor and activities of daily living (ADL) at 6 months, 1 year, 2-3 years, 4-5 years, and ≥6 years after surgery. RESULTS: Twenty-six patients with DT and 97 patients with ET were analyzed. Compared to preoperative baseline, there were significant improvements in TRS motor up to 4-5 years (52.2%; p = 0.032) but this did not reach statistical significance at ≥6 years (46.0%, p = 0.063) in DT, which was comparable to the outcomes in ET. While the improvements in the upper extremity tremor, head tremor, and axial tremor were also comparable between DT and ET throughout the follow-up, the ADL improvements in DT were lost at 2-3 years follow-up. CONCLUSION: Overall, tremor control with VIM DBS in DT and ET was comparable and remained sustained at long term likely related to intervention at the final common node in the pathologic tremor network. However, the long-term ADL improvements in DT were not sustained, possibly due to inadequate control of concomitant dystonia symptoms. These findings from a large cohort of DT indicate that VIM targeting is reasonable if the tremor is considerably more disabling than the dystonic features. CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that VIM DBS improves tremor in patients with DT or ET.

    DOI: 10.1212/WNL.0000000000008875

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  6. Distinct phenotypes of speech and voice disorders in Parkinson's disease after subthalamic nucleus deep brain stimulation

    Tsuboi Takashi, Watanabe Hirohisa, Tanaka Yasuhiro, Ohdake Reiko, Yoneyama Noritaka, Hara Kazuhiro, Nakamura Ryoichi, Watanabe Hazuki, Senda Jo, Atsuta Naoki, Ito Mizuki, Hirayama Masaaki, Yamamoto Masahiko, Fujimoto Yasushi, Kajita Yasukazu, Wakabayashi Toshihiko, Sobue Gen

    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY   Vol. 86 ( 8 ) page: 856 - 864   2015.8

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    Language:Japanese   Publisher:Journal of Neurology, Neurosurgery and Psychiatry  

    Objectives To elucidate the phenotypes and pathophysiology of speech and voice disorders in Parkinson's disease (PD) with subthalamic nucleus deep brain stimulation (STN-DBS). Methods We conducted a cross-sectional study on 76 PD patients treated with bilateral STN-DBS (PD-DBS) and 33 medically treated PD patients (PD-Med). Speech and voice functions, electrode positions, motor function and cognitive function were comprehensively assessed. Moreover, speech and voice functions were compared between the on-stimulation and off-stimulation conditions in 42 PD-DBS patients. Results Speech and voice disorders in PD-DBS patients were significantly worse than those in PD-Med patients. Factor analysis and subsequent cluster analysis classified PD-DBS patients into five clusters: relatively good speech and voice function type, 25%; stuttering type, 24%; breathy voice type, 16%; strained voice type, 18%; and spastic dysarthria type, 17%. STN-DBS ameliorated voice tremor or low volume; however, it deteriorated the overall speech intelligibility in most patients. Breathy voice did not show significant changes and stuttering exhibited slight improvement after stopping stimulation. In contrast, patients with strained voice type or spastic dysarthria type showed a greater improvement after stopping stimulation. Spastic dysarthria type patients showed speech disorders similar to spastic dysarthria, which is associated with bilateral upper motor neuron involvement. Strained voice type and spastic dysarthria type appeared to be related to current diffusion to the corticobulbar fibres. Conclusions Stuttering and breathy voice can be aggravated by STN-DBS, but are mainly due to aging or PD itself. Strained voice and spastic dysarthria are considered corticobulbar side effects.

    DOI: 10.1136/jnnp-2014-308043

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  7. Outcomes and Prognostic Factors of Magnetic Resonance-guided Focused Ultrasound Thalamotomy for Essential Tremor at 2-year Follow-up. Reviewed

    Hashida M, Maesawa S, Kato S, Nakatsubo D, Tsugawa T, Torii J, Tanei T, Ishizaki T, Mutoh M, Ito Y, Tsuboi T, Mizuno S, Suzuki M, Wakabayashi T, Katsuno M, Saito R

    Neurologia medico-chirurgica   Vol. advpub ( 0 )   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:The Japan Neurosurgical Society  

    Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is an effective treatment for essential tremor (ET). However, its long-term outcomes and prognostic factors remain unclear. This study aimed to retrospectively investigate 38 patients with ET who underwent MRgFUS thalamotomy and were followed up for >2 years. The improvement in tremor was evaluated using the Clinical Rating Scale for Tremor (CRST). Adverse events were documented, and correlations with factors, such as skull density ratio (SDR), maximum mean temperature (T-max), and lesion size, were examined. Furthermore, the outcomes were compared between two groups, one that met the cutoff values, which was previously reported (preoperative CRST-B ≤ 25, T-max ≥ 52.5°C, anterior-posterior size of lesion ≥ 3.9 mm, superior-inferior [SI] size of lesion > 5.5 mm), and the other that did not. The improvement rate was 59.4% on average at the 2-year follow-up. Adverse events, such as numbness (15.8%), dysarthria (10.5%), and lower extremity weakness (2.6%), were observed even after 2 years, although these were mild. The factors correlated with tremor improvement were the T-max and SI size of the lesion (p < 0.05), whereas the SDR showed no significance. Patients who met the aforementioned cutoff values demonstrated a 69.8% improvement at the 2-year follow-up, whereas others showed a 43.6% improvement (p < 0.05). In conclusion, MRgFUS is effective even after 2 years. The higher the T-max and the larger the lesion size, the better the tremor control. Previously reported cutoff values clearly predict the 2-year prognosis, indicating the usefulness of MRgFUS.

    DOI: 10.2176/jns-nmc.2023-0202

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  8. Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor. Reviewed

    Bagarinao E, Maesawa S, Kato S, Mutoh M, Ito Y, Ishizaki T, Tanei T, Tsuboi T, Suzuki M, Watanabe H, Hoshiyama M, Isoda H, Katsuno M, Sobue G, Saito R

    Parkinsonism & related disorders   Vol. 121   page: 106034   2024.2

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    Language:English   Publisher:Parkinsonism and Related Disorders  

    Introduction: Connector hubs are specialized brain regions that connect multiple brain networks and therefore have the potential to affect the functions of multiple systems. This study aims to examine the involvement of connector hub regions in essential tremor. Methods: We examined whole-brain functional connectivity alterations across multiple brain networks in 27 patients with essential tremor and 27 age- and sex-matched healthy controls to identify affected hub regions using a network metric called functional connectivity overlap ratio estimated from resting-state functional MRI. We also evaluated the relationships of affected hubs with cognitive and tremor scores in all patients and with motor function improvement scores in 15 patients who underwent postoperative follow-up evaluations after focused ultrasound thalamotomy. Results: We have identified affected connector hubs in the cerebellum and thalamus. Specifically, the dentate nucleus in the cerebellum and the dorsomedial thalamus exhibited more extensive connections with the sensorimotor network in patients. Moreover, the connections of the thalamic pulvinar with the visual network were also significantly widespread in the patient group. The connections of these connector hub regions with cognitive networks were negatively associated (FDR q < 0.05) with cognitive, tremor, and motor function improvement scores. Conclusion: In patients with essential tremor, connector hub regions within the cerebellum and thalamus exhibited widespread functional connections with sensorimotor and visual networks, leading to alternative pathways outside the classical tremor axis. Their connections with cognitive networks also affect patients’ cognitive function.

    DOI: 10.1016/j.parkreldis.2024.106034

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  9. Plasma biomarkers of neurodegeneration in patients with Parkinson’s disease and dementia with Lewy bodies and at-risk individuals of Lewy body disease in the NaT-PROBE cohort Reviewed

    Keita Hiraga, Makoto Hattori, Yuki Satake, Daigo Tamakoshi, Taiki Fukushima, Takashi Uematsu, Takashi Tsuboi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Yukihiko Washimi, Akihiro Hori, Masayuki Yamamoto, Hideaki Shimizu, Masakazu Wakai, Harutsugu Tatebe, Takahiko Tokuda, Akinori Nakamura, Shumpei Niida, Masahisa Katsuno

        2023.12

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  10. Preoperative Recording of Original Voices in Laryngectomized Patients : The Save the Voice Project Reviewed

    Nishio Naoki, Toda Tomoki, Kobayashi Kazuhiro, Mitani Sohei, Ameya Misato, Mukoyama Nobuaki, Kimura Hiroyuki, Tokura Tatsuya, Tsuboi Takashi, Fujimoto Yasushi, Sone Michihiko

    Koutou (THE LARYNX JAPAN)   Vol. 35 ( 2 ) page: 142 - 147   2023.12

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    Language:Japanese   Publisher:THE JAPAN LARYNGOLOGICAL ASSOCIATION  

    <p>Laryngectomy still plays an important role in the treatment of head and neck cancer. However, laryngectomized patients experience several difficulties in their lives because of the loss of their original voice. This study aimed to record the original voice before laryngectomy via a recording application or studio recording in patients who planned to undergo laryngectomy (Save the Voice project). In 2021, a multicenter prospective observational study was initiated for patients who planned to undergo laryngectomy in Japan. Before surgery, patients recorded their original voices using a voice recording application or in a recording studio. After laryngectomy, electrolarynx voices were obtained and stored in our database system. The study included 34 patients who were managed in three academic university hospitals (30 males, 4 females; median age at the time of surgery, 69 [range, 46–80] years). The tumor sites were the hypopharynx in 21 patients, esophagus in 6, larynx in 5, oropharynx in 1, and trachea in 1 patient. Among the 34 patients, the original voices were preoperatively recorded via a voice-recording application in 28 patients and via a recording studio in 6 patients. Preoperative recording of the patient’s original voice is essential to regenerate the voice after laryngectomy.</p>

    DOI: 10.5426/larynx.35.142

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  11. Efficacy of endoscopic cricopharyngeal myotomy using a curved rigid laryngoscope in patients with sporadic inclusion body myositis: four retrospective case reviews.

    Mayu Shigeyama, Naoki Nishio, Sayaka Yokoi, Nobuaki Mukoyama, Akihisa Wada, Takashi Maruo, Seiya Noda, Ayuka Murakami, Takashi Tsuboi, Masahisa Katsuno, Yasushi Fujimoto, Michihiko Sone

    Nagoya journal of medical science   Vol. 85 ( 4 ) page: 866 - 874   2023.11

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    Sporadic inclusion body myositis (s-IBM) is an acquired degenerative inflammatory myopathy that leads to slowly progressive muscle weakness and atrophy of the limbs, face, and pharynx. Owing to the slow progression of the disease, the indications for surgical intervention remain unclear. Herein, we retrospectively reviewed the records of four patients with s-IBM who had undergone cricopharyngeal myotomy for severe dysphagia at our institution between 2016 and 2021. Among these, one patient underwent transcervical cricopharyngeal myotomy and laryngeal suspension, as videofluoroscopic examination of swallowing revealed poor laryngeal elevation. The remaining three patients underwent endoscopic cricopharyngeal myotomy using a curved rigid laryngoscope. Preoperatively, the mean Hyodo score was 8 points (range: 6-10) using a flexible endoscope. The mean surgical duration was 104 min, and no severe complications were observed. Postoperatively, all patients achieved improvement in swallowing function and food intake. Moreover, swallowing function was maintained in all four patients even 6-12 months postoperatively. Cricopharyngeal myotomy may be a safe surgical procedure with the potential to improve swallowing function, and a Hyodo score of 6 may be considered a surgical indication for cricopharyngeal myotomy in patients with s-IBM.

    DOI: 10.18999/nagjms.85.4.866

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  12. Effect of education regarding treatment guidelines for schizophrenia and depression on the treatment behavior of psychiatrists: A multicenter study.

    Hasegawa N, Yasuda Y, Yasui-Furukori N, Yamada H, Hori H, Ichihashi K, Takaesu Y, Iida H, Muraoka H, Kodaka F, Iga JI, Hashimoto N, Ogasawara K, Ohi K, Fukumoto K, Numata S, Tsuboi T, Usami M, Hishimoto A, Furihata R, Kishimoto T, Nakamura T, Katsumoto E, Ochi S, Nagasawa T, Atake K, Kubota C, Komatsu H, Yamagata H, Ide K, Takeshima M, Kido M, Kikuchi S, Okada T, Matsumoto J, Miura K, Shimazu T, Inada K, Watanabe K, Hashimoto R

    Psychiatry and clinical neurosciences     2023.9

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    DOI: 10.1111/pcn.13578

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  13. 音声にてre-emergent tremorを呈したパーキンソン病例

    坪井 丈治, 田中 康博, 小林 孝輔, 橋本 里奈, 伊藤 陽子, 西尾 直樹, 坪井 崇, 曾根 三千彦, 勝野 雅央, 饗場 郁子

    言語聴覚研究   Vol. 20 ( 3 ) page: 195 - 196   2023.9

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    Language:Japanese   Publisher:(一社)日本言語聴覚士協会  

  14. 嗄声の検出にケプストラム分析が有効であった球脊髄性筋萎縮症の1例

    小林 孝輔, 田中 康博, 坪井 丈治, 橋本 里奈, 伊藤 陽子, 西尾 直樹, 坪井 崇, 曾根 三千彦, 勝野 雅央, 饗場 郁子

    言語聴覚研究   Vol. 20 ( 3 ) page: 272 - 273   2023.9

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  15. Analysis of spontaneous speech in Parkinson's disease by natural language processing. Reviewed

    Yokoi K, Iribe Y, Kitaoka N, Tsuboi T, Hiraga K, Satake Y, Hattori M, Tanaka Y, Sato M, Hori A, Katsuno M

    Parkinsonism & related disorders   Vol. 113   page: 105411   2023.8

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    <h4>Introduction</h4>Patients with Parkinson's disease (PD) encounter a variety of speech-related problems, including dysarthria and language disorders. To elucidate the pathophysiological mechanisms for linguistic alteration in PD, we compared the utterance of patients and that of healthy controls (HC) using automated morphological analysis tools.<h4>Methods</h4>We enrolled 53 PD patients with normal cognitive function and 53 HC, and assessed their spontaneous speech using natural language processing. Machine learning algorithms were used to identify the characteristics of spontaneous conversation in each group. Thirty-seven features focused on part-of-speech and syntactic complexity were used in this analysis. A support-vector machine (SVM) model was trained with ten-fold cross-validation.<h4>Results</h4>PD patients were found to speak less morphemes on one sentence than the HC group. Compared to HC, the speech of PD patients had a higher rate of verbs, case particles (dispersion), and verb utterances, and a lower rate of common noun utterances, proper noun utterances, and filler utterances. Using these conversational changes, the respective discrimination rates for PD or HC were more than 80%.<h4>Conclusions</h4>Our results demonstrate the potential of natural language processing for linguistic analysis and diagnosis of PD.

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  16. Clinico-imaging features of subjects at risk of Lewy body disease in NaT-PROBE baseline analysis Reviewed

    Makoto Hattori, Keita Hiraga, Yuki Satake, Takashi Tsuboi, Daigo Tamakoshi, Maki Sato, Katsunori Yokoi, Keisuke Suzuki, Yutaka Arahata, Akihiro Hori, Motoshi Kawashima, Hideaki Shimizu, Hiroshi Matsuda, Katsuhiko Kato, Yukihiko Washimi, Masahisa Katsuno

    npj Parkinson's Disease   Vol. 9 ( 1 ) page: 67   2023.4

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    DOI: 10.1038/s41531-023-00507-y

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  17. Safety and Clinical Benefits of Laryngeal Closure in Patients with Amyotrophic Lateral Sclerosis. Reviewed

    Yokoi S, Naoki Nishio, Maruo T, Hiramatsu M, Mukoyama N, Tsuzuki H, Wada A, Atsuta N, Ito D, Takashi Tsuboi, Sobue G, Katsuno M, Fujimoto Y, Michihiko Sone

    Dysphagia   Vol. 38 ( 1 ) page: 211 - 219   2023.2

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    This study evaluated the safety of laryngeal closure and post-surgical changes in swallowing function of patients with amyotrophic lateral sclerosis (ALS) and proposed an appropriate surgical strategy for patients with ALS. Clinical and surgical data of 26 consecutive patients with ALS who underwent laryngeal closure at Nagoya University Hospital in Japan between 2003 and 2020 were retrospectively analyzed. Changes in swallowing functions were evaluated before and approximately 1 month post-surgery using Neuromuscular Disease Swallowing Status Scale (NdSSS), and Functional Oral Intake Scale (FOIS). The median operation time was 126 min (range, 51-163 min), and the median intraoperative blood loss was 20 mL (range, 0-88 mL). Among the 26 ALS patients who underwent laryngeal closure, grade 1 (mild) complications occurred in three patients (12%); however, no severe complications were observed. After surgery, 25 patients (96%) maintained the swallowing function and only one patient (4%) had deteriorating NdSSS and FOIS scores. No patients were referred to our hospital due to severe aspiration pneumonia after the surgery. Two patients did not require a feeding tube after the surgery and returned to oral intake. Laryngeal closure may be a safe surgical procedure for preventing chronic aspiration and may also maintain swallowing function of patients with ALS. Further multicenter prospective studies using the gold standard videofluoroscopic swallowing examination are required to support our findings.

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  18. Cutoff values for the best management strategy for magnetic resonance-guided focused ultrasound ablation for essential tremor. Reviewed

    Torii J, Maesawa S, Nakatsubo D, Tsugawa T, Kato S, Ishizaki T, Takai S, Shibata M, Wakabayashi T, Takashi Tsuboi, Suzuki M, Saito R

    Journal of neurosurgery   Vol. 138 ( 1 ) page: 38 - 49   2023.1

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    <h4>Objective</h4>The efficacy of magnetic resonance-guided focused ultrasound (MRgFUS) ablation for essential tremor (ET) is well known; however, no prognostic factors have been established. The authors aimed to retrospectively investigate MRgFUS ablation outcomes and associated factors and to define the cutoff values for each prognostic factor.<h4>Methods</h4>Sixty-four Japanese patients who underwent unilateral ventral intermediate nucleus thalamotomy with MRgFUS for ET were included. Follow-up evaluations were performed at 1 week and 1, 3, 6, 12, and 24 months postoperatively. Tremor suppression was evaluated using the Clinical Rating Scale for Tremor (CRST), and adverse effects were recorded postoperatively. Outcome-associated factors were examined preoperatively, intraoperatively, and postoperatively using multivariate analyses. The cutoff values for the prognostic factors were calculated using receiver operating characteristics.<h4>Results</h4>Percentage improvements in the CRST scores of the affected upper limb were 82.4%, 72.2%, 68.6%, and 65.9% at 1, 3, 6, and 12 months, respectively. Preoperatively, a high skull density ratio (SDR) (p ≤ 0.047), low CRST part B score (used to assess tremors during several tasks) (cutoff value 25, p ≤ 0.041), and nonoccurrence of resting tremors (p = 0.027) were significantly associated with improved tremor control. An intraoperatively high maximum mean temperature (cutoff value 52.5°C, p ≤ 0.047), postoperatively large lesion (cutoff value 3.9 mm in the anterior-posterior direction, p ≤ 0.002; cutoff value 5.0-5.55 mm in the superior-inferior direction, p ≤ 0.026), and small transducer focus correction (p ≤ 0.015) were also associated with improved tremor control. No valid cutoff value was found for SDR. Adverse effects (limb weakness, sensory disturbance, ataxia/walking disturbance, dysgeusia, dysarthria, and facial swelling) occurred transiently and were associated with high SDR, high temperature, high number of sonication sessions, large lesion, and occurrence of resting tremor. Patients who developed leg weakness experienced greater percentage improvement in tremors at 3 months postoperatively than those who did not.<h4>Conclusions</h4>MRgFUS ablation could be used to achieve good tremor control with acceptable adverse effects in Japanese patients with ET. The relatively low SDR in Asian ethnic groups as compared with that of Western populations makes treatment difficult; however, the cutoff values obtained in this study may be useful for achieving good treatment outcomes even in such patients. Clinical trial registration no.: UMIN000026952 (University Hospital Medical Information Network).<h4>Abbreviations</h4>ACPC = anterior commissure-posterior commissure; AP = anterior to posterior; CRST = Clinical Rating Scale for Tremor; ET = essential tremor; MRgFUS = magnetic resonance-guided focused ultrasound; PC = posterior commissure; PSA = posterior subthalamic area; RL = right to left; ROC = receiver operating characteristic; SDR = skull density ratio; SI = superior to inferior; T2WI = T2-weighted imaging; VIM = ventral intermediate nucleus.

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  19. A case report: Dual-lead deep brain stimulation of the posterior subthalamic area and the thalamus was effective for Holmes tremor after unsuccessful focused ultrasound thalamotomy. Reviewed

    Maesawa S, Torii J, Nakatsubo D, Noda H, Mutoh M, Ito Y, Ishizaki T, Takashi Tsuboi, Suzuki M, Tanei T, Katsuno M, Saito R

    Frontiers in human neuroscience   Vol. 16   page: 1065459   2022.12

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    Holmes tremor is a symptomatic tremor that develops secondary to central nervous system disorders. Stereotactic neuromodulation is considered when the tremors are intractable. Targeting the ventral intermediate nucleus (Vim) is common; however, the outcome is often unsatisfactory, and the posterior subthalamic area (PSA) is expected as alternative target. In this study, we report the case of a patient with intractable Holmes tremor who underwent dual-lead deep brain stimulation (DBS) to stimulate multiple locations in the PSA and thalamus. The patient was a 77-year-old female who complained of severe tremor in her left upper extremity that developed one year after her right thalamic infarction. Vim-thalamotomy using focused ultrasound therapy (FUS) was initially performed but failed to control tremor. Subsequently, we performed DBS using two leads to stimulate four different structures. Accordingly, one lead was implanted with the aim of targeting the ventral oralis nucleus (Vo)/zona incerta (Zi), and the other with the aim of targeting the Vim/prelemniscal radiation (Raprl). Electrode stimulation revealed that Raprl and Zi had obvious effects. Postoperatively, the patient achieved good tremor control without any side effects, which was maintained for two years. Considering that she demonstrated resting, postural, and intention/action tremor, and Vim-thalamotomy by FUS was insufficient for tremor control, complicated pathogenesis was presumed in her symptoms including both the cerebellothalamic and the pallidothalamic pathways. Using the dual-lead DBS technique, we have more choices to adjust the stimulation at multiple sites, where different functional networks are connected. Intractable tremors, such as Holmes tremor, may have complicated pathology, therefore, modulating multiple pathological networks is necessary. We suggest that the dual-lead DBS (Vo/Raprl and Vim/Zi) presented here is safe, technically feasible, and possibly effective for the control of Holmes tremor.

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  20. [Dyskinesia-hyperpyrexia syndrome triggered by overdose of istradefylline: a case report].

    Shota Komori, Takashi Tsuboi, Masashi Suzuki, Tomohiko Nakamura, Masahisa Katsuno

    Rinsho shinkeigaku = Clinical neurology   Vol. 62 ( 8 ) page: 627 - 631   2022.8

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    We present a 71-year-old woman with an eight-year history of Parkinson's disease (PD). She began to experience wearing-off at the age of 66 and subsequently developed dyskinesia. She had worsened dyskinesias for three days, followed by a high fever, and she was subsequently hospitalized. On admission, severe dyskinesia, hyperpyrexia, and elevation of serum creatine kinase were observed. Severe dyskinesia without rigidity continued throughout the day and she was diagnosed with dyskinesia-hyperpyrexia syndrome (DHS). She was treated with standard medical care and anti-parkinsonian medications were reduced drastically. Dyskinesia started to wane three days after admission and almost disappeared on day twelve. Prior to admission, the patient reported she had been taking two to three times the dose prescribed of istradefylline, which was the suspected to be a trigger of DHS. Because DHS is a rare but potentially life-threatening complication, early recognition and diagnosis is vital. A proper treatment strategy for DHS may include standard medical care together with reduced anti-parkinsonian medications.

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  21. Eosinophilic granulomatosis with polyangiitis complicated with idiopathic thrombocytopenic purpura and sclerosing cholangitis showing eosinophilic infiltration. Reviewed

    Yuta Yamashita, Takuya Takeichi, Ishizu Y, Suzuki N, Takashi Tsuboi, Matsuura K, Haruka Koizumi, Yoshinao Muro, Masashi Akiyama

    The Journal of dermatology   Vol. 49 ( 8 ) page: E270 - E271   2022.8

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  22. Magnetic resonance-guided focused ultrasound thalamotomy restored distinctive resting-state networks in patients with essential tremor. International journal

    Sachiko Kato, Satoshi Maesawa, Epifanio Bagarinao, Daisuke Nakatsubo, Takahiko Tsugawa, Satomi Mizuno, Kazuya Kawabata, Takashi Tsuboi, Masashi Suzuki, Masashi Shibata, Sou Takai, Tomotaka Ishizaki, Jun Torii, Manabu Mutoh, Ryuta Saito, Toshihiko Wakabayashi, Masahisa Katsuno, Norio Ozaki, Hirohisa Watanabe, Gen Sobue

    Journal of neurosurgery     page: 1 - 12   2022.7

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    <h4>Objective</h4>Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy ameliorates symptoms in patients with essential tremor (ET). How this treatment affects canonical brain networks has not been elucidated. The purpose of this study was to clarify changes of brain networks after MRgFUS thalamotomy in ET patients by analyzing resting-state networks (RSNs).<h4>Methods</h4>Fifteen patients with ET were included in this study. Left MRgFUS thalamotomy was performed in all cases, and MR images, including resting-state functional MRI (rsfMRI), were taken before and after surgery. MR images of 15 age- and sex-matched healthy controls (HCs) were also used for analysis. Using rsfMRI data, canonical RSNs were extracted by performing dual regression analysis, and the functional connectivity (FC) within respective networks was compared among pre-MRgFUS patients, post-MRgFUS patients, and HCs. The severity of tremor was evaluated using the Clinical Rating Scale for Tremor (CRST) score pre- and postoperatively, and its correlation with RSNs was examined.<h4>Results</h4>Preoperatively, ET patients showed a significant decrease in FC in the sensorimotor network (SMN), primary visual network (VN), and visuospatial network (VSN) compared with HCs. The decrease in FC in the SMN correlated with the severity of tremor. After MRgFUS thalamotomy, ET patients still exhibited a significant decrease in FC in a small area of the SMN, but they exhibited an increase in the cerebellar network (CN). In comparison between pre- and post-MRgFUS patients, the FC in the SMN and the VSN significantly increased after treatment. Quantitative evaluation of the FCs in these three groups showed that the SMN and VSN increased postoperatively and demonstrated a trend toward those of HCs.<h4>Conclusions</h4>The SMN and CN, which are considered to be associated with the cerebello-thalamo-cortical loop, exhibited increased connectivity after MRgFUS thalamotomy. In addition, the FC of the visual network, which declined in ET patients compared with HCs, tended to normalize postoperatively. This could be related to the hypothesis that visual feedback is involved in tremor severity in ET patients. Overall, the analysis of the RSNs by rsfMRI reflected the pathophysiology with the intervention of MRgFUS thalamotomy in ET patients and demonstrated a possibility of a biomarker for successful treatment.

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  23. Evolving Concepts in Our Understanding and Treatment of Holmes Tremor, Over 100 Years in the Making. Reviewed

    Hey G, wei Hu, Wong J, Takashi Tsuboi, Matthew Burns, Adolfo Ramirez-Zamora

    Tremor and other hyperkinetic movements (New York, N.Y.)   Vol. 12 ( 1 ) page: 1 - 12   2022.5

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    Holmes Tremor (HT) is an irregular, slow-frequency (<4.5 Hz) tremor characterized by a combination of resting, postural, and action tremors mostly of the upper extremities. Symptoms of HT typically emerge 4 weeks to 2 years after a brain injury caused by a spectrum of etiologies. HT pathophysiology is thought to result from aberrant collateral axonal sprouting and synaptic dysfunction following neuronal damage. To date, the dopaminergic nigrostriatal system, cerebello-thalamo-cortical pathway, and dentate-rubro-olivary pathway have all been implicated in the clinical manifestations of HT. The diversity of HT etiologies usually requires a personalized treatment plan. Current treatment options include carbidopa-levodopa, levetiracetam, and trihexyphenidyl, and surgical management such as deep brain stimulation in selected medication-refractory patients. In this review we discuss the pathophysiology, etiology, neuroimaging, and the latest clinical guidelines for care and management of HT.

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  24. Using Self-learning Representations for Objective Assessment of Patient Voice in Dysphonia

    Dang, SX; Matsumoto, T; Takeuchi, Y; Kudo, H; Tsuboi, T; Tanaka, Y; Katsuno, M

    PROCEEDINGS OF 2022 ASIA-PACIFIC SIGNAL AND INFORMATION PROCESSING ASSOCIATION ANNUAL SUMMIT AND CONFERENCE (APSIPA ASC)     page: 359 - 363   2022

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  25. Instability of speech in Parkinson disease patients with subthalamic nucleus deep brain stimulation Reviewed

    Tanaka Yasuhiro, Tsuboi Takashi, Watanabe Hirohisa, Torii Jun, Nakatsubo Daisuke, Maesawa Satoshi, Sato Maki, Hiraga Keita, Satake Yuki, Yokoi Katsunori, Hattori Makoto, Kawabata Kazuya, Hara Kazuhiro, Yamamoto Masahiko, Sobue Gen, Katsuno Masahisa

    PARKINSONISM AND RELATED DISORDERS   Vol. 93   page: 8 - 11   2021.11

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    Introduction: The impact of deep brain stimulation (DBS) on speech rhythm and its mechanism remains unclear. We investigated speech rhythm characteristics of patients with Parkinson's disease (PD) treated with subthalamic nucleus (STN) DBS to understand the underlying pathophysiology better. Methods: We enrolled a total of 105 participants and evaluated speech rhythm performances among patients with PD who had undergone STN-DBS (the PD-DBS group), patients with PD treated only with medication (the PD-Med group), patients with cerebellar ataxia (the CA group), and healthy controls (the HC group). Each participant was asked to repeat the syllable/pa/at a comfortable self-chosen steady pace. A widely-used software (the Motor Speech Profile) program performed an acoustic analysis. Results: Compared to the PD-Med and HC groups, speech rate instability (DDKjit) was significantly higher in the PD-DBS and CA groups (p < 0.01). However, after DBS was turned off, the DDKjit of the PD-DBS group improved to a level comparable to that of the PD-Med and HC groups. In contrast to the significantly higher variability of speech volume (DDKcvi) in the CA group, the PD-DBS group showed similar DDKcvi to the PD-Med and HC groups. Conclusions: STN-DBS affects the speech rate stability of patients with PD. Speech rhythm disorders caused by STN-DBS were phenotypically similar to that in CA in terms of interval variability but different regarding amplitude variability. Further studies are warranted to elucidate the underlying pathophysiology of speech rhythm disorders in PD patients treated with DBS.

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  26. 筋生検が診断の一助となったALアミロイドーシスの1例

    平野 聡子, 坪井 崇, 中村 友彦, 野田 成哉, 小池 春樹, 西田 徹也, 勝野 雅央

    臨床神経学   Vol. 61 ( 11 ) page: 787 - 787   2021.11

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  27. Corrigendum to: Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation. Reviewed International coauthorship

    Tsuboi T, Wong JK, Eisinger RS, Okromelidze L, Burns MR, Ramirez-Zamora A, Almeida L, Shukla AW, Foote KD, Okun MS, Grewal SS, Middlebrooks EH

    Brain : a journal of neurology   Vol. 144 ( 8 ) page: e71   2021.9

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  28. Evolution of Globus Pallidus Targeting for Parkinson's and Dystonia Deep Brain Stimulation: A 15-Year Experience Reviewed International coauthorship

    Holanda Vanessa M., Eisinger Robert Stephen, Almeida Leonardo, Tsuboi Takashi, Wang Huimin, Okun Michael S., Deeb Wissam, Patterson Addie, Shukla Aparna Wagle, Lopes Janine Lobo, Foote Kelly Douglas

    FRONTIERS IN NEUROLOGY   Vol. 12   page: 679918   2021.8

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    Objective: The aim of this study is to evaluate the evolution of GPi DBS targeting. Methods: This retrospective, single-center study included patients implanted with GPi DBS leads for dystonia or PD during the years 2004 to 2018 at the University of Florida Fixel Institute for Neurological Diseases. Each patient underwent a high-resolution targeting study on the day prior to the surgery, which was fused with a high resolution CT scan that was acquired on the day of the procedure. Intraoperative target location was selected using a digitized 3D Schaltenbrand-Bailey atlas. All patients underwent a high-resolution head CT scan without contrast approximately one month after lead implantation and accurate measurement of neuroanatomical lead position was acquired after fusion of pre-operative and post-operative image studies. Results: We analyzed 253 PD patients with 352 leads and 80 dystonia patients with 141 leads. During 15 years of follow-up, lead locations in the PD group migrated more laterally (β = 0.09, p < 0.0001), posteriorly [slope (β) = 0.04, p < 0.05], and dorsally (β = 0.07, p < 0.001), whereas leads in the dystonia group did not significantly change position aside from a trend in the dorsal direction (β = 0.06, p = 0.053). Conclusion: The evolving target likely results from multiple factors including improvements in targeting techniques and clinical feedback intraoperatively and post-operatively. Our demonstrates the potential importance of a systematic post-operative DBS lead measurement protocol to ensure quality control and to inform and optimize DBS programming.

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  29. Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson's Disease Reviewed International coauthorship

    Wong Joshua K., Hu Wei, Barmore Ryan, Lopes Janine, Moore Kathryn, Legacy Joseph, Tahafchi Parisa, Jackson Zachary, Judy Jack W., Raike Robert S., Wang Anson, Tsuboi Takashi, Okun Michael S., Almeida Leonardo

    FRONTIERS IN HUMAN NEUROSCIENCE   Vol. 15   page: 651168   2021.4

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    Background: Freezing of gait (FOG) is a common symptom in Parkinson’s disease (PD) and can be difficult to treat with dopaminergic medications or with deep brain stimulation (DBS). Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation (BCDBS) delivers current in various frequencies of bursts (e.g., 4, 10, or 15 Hz), while maintaining an intra-burst frequency identical to conventional DBS. Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG. Methods: Ten PD subjects with STN or GPi DBS and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state. Results: There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS. Conclusions: BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy.

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  30. Connectivity correlates to predict essential tremor deep brain stimulation outcome: Evidence for a common treatment pathway. Reviewed

    Erik Middlebrooks, Okromelidze L, Joshua Wong, Eisinger RS, Burns MR, Jain A, Lin HP, Yu J, Opri E, Andreas Horn, Lukas L Goede, Foote KD, Okun MS, Quiñones-Hinojosa A, Uitti RJ, Grewal SS, Takashi Tsuboi

    NeuroImage. Clinical   Vol. 32   page: 102846   2021

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    <h4>Background and purpose</h4>Deep brain stimulation (DBS) is the most common surgical treatment for essential tremor (ET), yet there is variation in outcome and stimulation targets. This study seeks to consolidate proposed stimulation "sweet spots," as well as assess the value of structural connectivity in predicting treatment outcomes.<h4>Materials and methods</h4>Ninety-seven ET individuals with unilateral thalamic DBS were retrospectively included. Using normative brain connectomes, structural connectivity measures were correlated with the percentage improvement in contralateral tremor, based on the Fahn-Tolosa-Marin tremor rating scale (TRS), after parameter optimization (range 3.1-12.9 months) using a leave-one-out cross-validation in 83 individuals. The predictive feature map was used for cross-validation in a separate cohort of 14 ET individuals treated at another center. Lastly, estimated volumes of tissue activated (VTA) were used to assess a treatment "sweet spot," which was compared to seven previously reported stimulation sweet spots and their relationship to the tract identified by the predictive feature map.<h4>Results</h4>In the training cohort, structural connectivity between the VTA and dentato-rubro-thalamic tract (DRTT) correlated with contralateral tremor improvement (R = 0.41; p < 0.0001). The same connectivity profile predicted outcomes in a separate validation cohort (R = 0.59; p = 0.028). The predictive feature map represented the anatomical course of the DRTT, and all seven analyzed sweet spots overlapped the predictive tract (DRTT).<h4>Conclusions</h4>Our results strongly support the possibility that structural connectivity is a predictor of contralateral tremor improvement in ET DBS. The results suggest the future potential for a patient-specific functionally based surgical target. Finally, the results showed convergence in "sweet spots" suggesting the importance of the DRTT to the outcome.

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  31. Globus Pallidus Internus (GPi) Deep Brain Stimulation for Parkinson's Disease: Expert Review and Commentary. Invited Reviewed International journal

    Ka Loong Kelvin Au, Joshua K Wong, Takashi Tsuboi, Robert S Eisinger, Kathryn Moore, Janine Lemos Melo Lobo Jofili Lopes, Marshall T Holland, Vanessa M Holanda, Zhongxing Peng-Chen, Addie Patterson, Kelly D Foote, Adolfo Ramirez-Zamora, Michael S Okun, Leonardo Almeida

    Neurology and therapy     2020.11

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    INTRODUCTION: The globus pallidus internus (GPi) region has evolved as a potential target for deep brain stimulation (DBS) in Parkinson's disease (PD). DBS of the GPi (GPi DBS) is an established, safe and effective method for addressing many of the motor symptoms associated with advanced PD. It is important that clinicians fully understand this target when considering GPi DBS for individual patients. METHODS: The literature on GPi DBS in PD has been comprehensively reviewed, including the anatomy, physiology and potential pitfalls that may be encountered during surgical targeting and post-operative management. Here, we review and address the implications of lead location on GPi DBS outcomes. Additionally, we provide a summary of randomized controlled clinical trials conducted on DBS in PD, together with expert commentary on potential applications of the GPi as target. Finally, we highlight future technologies that will likely impact GPi DBS, including closed-loop adaptive approaches (e.g. sensing-stimulating capabilities), advanced methods for image-based targeting and advances in DBS programming, including directional leads and pulse shaping. RESULTS: There are important disease characteristics and factors to consider prior to selecting the GPi as the DBS target of PD surgery. Prior to and during implantation of the leads it is critical to consider the neuroanatomy, which can be defined through the combination of image-based targeting and intraoperative microelectrode recording strategies. There is an increasing body of literature on GPi DBS in patients with PD suggesting both short- and long-term benefits. Understanding the GPi target can be useful in choosing between the subthalamic (STN), GPi and ventralis intermedius nucleus as lead locations to address the motor symptoms and complications of PD. CONCLUSION: GPi DBS can be effectively used in select cases of PD. As the ongoing DBS target debate continues (GPi vs. STN as DBS target), clinicians should keep in mind that GPi DBS has been shown to be an effective treatment strategy for a variety of symptoms, including bradykinesia, rigidity and tremor control. GPi DBS also has an important, direct anti-dyskinetic effect. GPi DBS is easier to program in the outpatient setting and will allow for more flexibility in medication adjustments (e.g. levodopa). Emerging technologies, including GPi closed-loop systems, advanced tractography-based targeting and enhanced programming strategies, will likely be future areas of GPi DBS expansion. We conclude that although the GPi as DBS target may not be appropriate for all PD patients, it has specific clinical advantages.

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  32. Cerebello-basal ganglia connectivity fingerprints related to motor/cognitive performance in Parkinson's disease. Reviewed International journal

    Kazuya Kawabata, Hirohisa Watanabe, Epifanio Bagarinao, Reiko Ohdake, Kazuhiro Hara, Aya Ogura, Michihito Masuda, Toshiyasu Kato, Takashi Tsuboi, Satoshi Maesawa, Masahisa Katsuno, Gen Sobue

    Parkinsonism & related disorders   Vol. 80   page: 21 - 27   2020.11

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    INTRODUCTION: The role of the cerebellum in Parkinson's disease (PD) has attracted increasing attention; however, the role of functional connectivity (FC) between the basal ganglia and particular cerebellar subregions remains to be elucidated. We aimed to clarify the FC and its contribution to motor and cognitive performances in patients with PD. METHODS: We included 99 patients with PD and 99 age- and sex-matched healthy controls in this study. We created a cerebellar functional parcellation by performing cerebellum-only independent component analysis. Using the functional parcellation map, we performed seed-based connectivity analysis using each region as a seed and extracted the mean correlation coefficients within the thalamus and basal ganglia, including the caudate, pallidum, putamen and subthalamic nucleus. We examined the group differences and correlations with the motor and general cognitive scores. In addition, we conducted a mediation analysis to clarify the relationship among FC, motor severity, and cognition. RESULTS: The PD group showed decreased FC between a wide range of cerebellar subregions and the basal ganglia. Motor severity was correlated with FC between the subthalamic nucleus and posterior Crus I/II, and general cognitive performance scores correlated with FC between the caudate nucleus and medial-posterior part of the Crus I/II (p < 0.05, corrected for multiple comparisons). The cerebello-caudate network had a direct effect on cognitive performance (p = 9.0 × 10-3), although partially mediated by motor performance (p = 8.2 × 10-3). CONCLUSION: FC between cerebellar Crus I/II and divergent basal ganglia related to motor and cognitive performance in PD.

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  33. Long-term clinical outcomes of bilateral GPi deep brain stimulation in advanced Parkinson's disease: 5 years and beyond. Reviewed International journal

    Takashi Tsuboi, Janine Lemos Melo Lobo Jofili Lopes, Kathryn Moore, Bhavana Patel, Joseph Legacy, Adrianna M Ratajska, Dawn Bowers, Robert S Eisinger, Leonardo Almeida, Kelly D Foote, Michael S Okun, Adolfo Ramirez-Zamora

    Journal of neurosurgery     page: 1 - 10   2020.10

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    OBJECTIVE: Few studies have reported long-term outcomes of globus pallidus internus (GPi) deep brain stimulation (DBS) in Parkinson's disease (PD). The authors aimed to investigate long-term outcomes of bilateral GPi DBS for 5 years and beyond for PD patients. METHODS: The authors retrospectively analyzed the clinical outcomes in 65 PD patients treated with bilateral GPi DBS at a single center. The outcome measures of motor symptoms and health-related quality of life (HRQoL) included the Unified Parkinson's Disease Rating Scale (UPDRS) and the Parkinson's Disease Questionnaire (PDQ-39). Scores at baseline were compared with those at 1, 3, 5, and 6-8 years after implantation using Wilcoxon signed-rank tests with α correction. RESULTS: GPi DBS significantly improved the off-medication UPDRS III total scores, UPDRS IV, and dyskinesia score at 1 year when compared with baseline (all p < 0.001). The off- and on-medication tremor scores, UPDRS IV, and dyskinesia scores showed moderate and sustained improvement (the ranges of the mean percentage improvement at each time point were 61%-75%, 30%-80%, 29%-40%, and 40%-65%, respectively) despite lacking statistical significance at long-term follow-up with diminishing sample sizes. The off-medication UPDRS III total scores did not show significant improvement at 5 years or later, primarily because of worsening in rigidity, akinesia, speech, gait, and postural stability scores. The on-medication UPDRS III total scores also worsened over time, with a significant worsening at 6-8 years when compared with baseline (p = 0.008). The HRQoL analyses based on the PDQ-39 revealed significant improvement in the activities of daily living and discomfort domains at 1 year (p = 0.003 and 0.006, respectively); however, all the domains showed gradual worsening at the later time points without reaching statistical significance. At 3 years, the communication domain showed significant worsening compared with baseline scores (p = 0.002). CONCLUSIONS: GPi DBS in PD patients in this single-center cohort was associated with sustained long-term benefits in the off- and on-medication tremor score and motor complications. HRQoL and the cardinal motor symptoms other than tremor may worsen gradually in the long term. When counseling patients, it is important to recognize that benefits in tremor and dyskinesia are expected to be most persistent following bilateral GPi DBS implantation.

    DOI: 10.3171/2020.6.JNS20617

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  34. Neuroimaging Advances in Deep Brain Stimulation: Review of Indications, Anatomy, and Brain Connectomics Reviewed International journal

    E.H. Middlebrooks, R.A. Domingo, T. Vivas-Buitrago, L. Okromelidze, T. Tsuboi, J.K. Wong, R.S. Eisinger, L. Almeida, M.R. Burns, A. Horn, R.J. Uitti, R.E. Wharen, Jr, V.M. Holanda, S.S. Grewal

    American Journal of Neuroradiology   Vol. 41 ( 9 ) page: 1558 - 1568   2020.9

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  35. Motor outcomes and adverse effects of deep brain stimulation for dystonic tremor: A systematic review. Reviewed International coauthorship International journal

    Takashi Tsuboi, Ka Loong Kelvin Au, Wissam Deeb, Leonardo Almeida, Kelly D Foote, Michael S Okun, Adolfo Ramirez-Zamora

    Parkinsonism & related disorders   Vol. 76   page: 32 - 41   2020.7

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    Dystonic tremor (DT) is defined as the tremor in body parts affected by dystonia. Although deep brain stimulation (DBS) has been used to manage medically-refractory DT patients, its efficacy has not been well established. The objective of this study is to provide an up-to-date systematic review of DBS outcomes for DT patients. We conducted a literature search using Medline, Embase, and Cochrane Library databases in February 2020 according to the PRISMA guidelines. From 858 publications, we identified 30 articles involving 89 DT patients who received DBS of different targets. Thalamic DBS was the most common (n = 39) and improved tremor by 40-50% potentially in the long-term over five years with variable effects on dystonic symptoms. Globus pallidus internus (GPi), subthalamic, and subthalamic nucleus (STN) DBS improved both tremor and dystonic symptoms; however, data were limited. A few studies have reported better tremor and dystonia outcomes with combinations of different targets. Concerning adverse effects, gait/balance disorders, and ataxia seemed to be more common among patients treated with thalamic or subthalamic DBS, whereas parkinsonian adverse effects were observed only in patients treated with subthalamic or GPi DBS. Comparative benefits and limitations of these targets remain unclear because of the lack of randomized controlled trials. In conclusion, DBS of these targets may improve tremor with a variable effect on dystonia with different adverse effect profiles. The shortcomings in the literature include long-term motor outcomes, quality of life outcomes, optimal DBS targeting, and DBS programming strategy.

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  36. Secondary Worsening Following DYT1 Dystonia Deep Brain Stimulation: A Multi-country Cohort. Reviewed International coauthorship International journal

    Takashi Tsuboi, Laura Cif, Philippe Coubes, Jill L Ostrem, Danilo A Romero, Yasushi Miyagi, Andres M Lozano, Philippe De Vloo, Ihtsham Haq, Fangang Meng, Nutan Sharma, Laurie J Ozelius, Aparna Wagle Shukla, James H Cauraugh, Kelly D Foote, Michael S Okun

    Frontiers in human neuroscience   Vol. 14   page: 242 - 242   2020.6

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    Objective: To reveal clinical characteristics of suboptimal responses to deep brain stimulation (DBS) in a multi-country DYT1 dystonia cohort. Methods: In this multi-country multi-center retrospective study, we analyzed the clinical data of DYT1 patients who experienced suboptimal responses to DBS defined as <30% improvement in dystonia scales at the last follow-up compared with baseline. We used a literature-driven historical cohort of 112 DYT1 patients for comparison. Results: Approximately 8% of our study cohort (11 out of 132) experienced suboptimal responses to DBS. Compared with the historical cohort, the multi-country cohort with suboptimal responses had a significantly younger age at onset (mean, 7.0 vs. 8.4 years; p = 0.025) and younger age at DBS (mean, 12.0 vs. 18.6 years; p = 0.019). Additionally, cranial involvement was more common in the multi-country cohort (before DBS, 64% vs. 45%, p = 0.074; before or after DBS, 91% vs. 47%, p = 0.001). Mean motor improvement at the last follow-up from baseline were 0% and 66% for the multi-country and historical cohorts, respectively. All 11 patients of the multi-country cohort had generalization of dystonia within 2.5 years after disease onset. All patients experienced dystonia improvement of >30% postoperatively; however, secondary worsening of dystonia commenced between 6 months and 3 years following DBS. The improvement at the last follow-up was less than 30% despite optimally-placed leads, a trial of multiple programming settings, and additional DBS surgeries in all patients. The on-/off-stimulation comparison at the long-term follow-up demonstrated beneficial effects of DBS despite missing the threshold of 30% improvement over baseline. Conclusion: Approximately 8% of patients represent a more aggressive phenotype of DYT1 dystonia characterized by younger age at onset, faster disease progression, and cranial involvement, which seems to be associated with long-term suboptimal responses to DBS (e.g., secondary worsening). This information could be useful for both clinicians and patients in clinical decision making and patient counseling before and following DBS implantations. Patients with this phenotype may have different neuroplasticity, neurogenetics, or possibly distinct neurophysiology.

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  37. Parkinson's disease motor subtypes and bilateral GPi deep brain stimulation: One-year outcomes. Reviewed International journal

    Takashi Tsuboi, Janine Lemos Melo Lobo Jofili Lopes, Bhavana Patel, Joseph Legacy, Kathryn Moore, Robert S Eisinger, Leonardo Almeida, Kelly D Foote, Michael S Okun, Adolfo Ramirez-Zamora

    Parkinsonism & related disorders   Vol. 75   page: 7 - 13   2020.6

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    OBJECTIVE: We aimed to explore the differences in motor symptoms and quality of life (QOL) outcomes following bilateral globus pallidus internus deep brain stimulation (GPi DBS), across well-defined motor subtypes of Parkinson's disease (PD), to improve clinical decision making. METHODS: This single-center retrospective study investigated bilateral GPi DBS outcomes in 65 PD patients. Outcome measures included the Unified Parkinson's Disease Rating Scale (UPDRS) and Parkinson's Disease Questionnaire (PDQ-39) before and one year after surgery. Outcomes were compared between the tremor-dominant (TD) and postural instability and gait difficulty (PIGD) subtypes and between the TD and akinetic-rigid (AR) subtypes. RESULTS: For the entire cohort, motor function (UPDRS III) in the Off-medication state, motor complications (UPDRS IV), activities of daily living (ADL, UPDRS II), and the ADL and discomfort domains of PDQ-39 significantly improved one year following GPi implantation compared to baseline (effect size = 1.32, 1.15, 0.25, 0.45, and 0.34, respectively). GPi DBS improved the Off-medication UPDRS III scores regardless of the motor subtypes. However, compared to the PIGD and AR patients, the TD patients showed greater improvement in overall UPDRS III postoperatively primarily due to greater tremor improvement in the Off-medication state. The outcomes in akinesia, rigidity, axial symptoms and QOL were similar among all subtypes. CONCLUSION: Bilateral GPi DBS was effective for advanced PD patients regardless of motor subtypes. Greater tremor improvement in the TD patients accounted for greater Off-medication motor improvement. Longer-term GPi DBS outcomes across different motor subtypes and brain targets should be further studied.

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  38. Steroid-responsive recurrent tumefactive demyelination with multiple petechial hemorrhages along non-displaced medullary veins. Reviewed International journal

    Takashi Tsuboi, Yumiko Harada, Masashi Suzuki, Takashi Ando, Naoki Atsuta, Fumiharu Ohka, Kazuhito Takeuchi, Toshiaki Taoka, Shigeo Ohba, Masato Nakaguro, Masato Abe, Ichiro Nakashima, Mari Yoshida, Masahisa Katsuno

    Clinical neurology and neurosurgery   Vol. 193   page: 105764 - 105764   2020.6

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  39. A pooled meta-analysis of GPi and STN deep brain stimulation outcomes for cervical dystonia. Reviewed International coauthorship International journal

    Takashi Tsuboi, Joshua K Wong, Leonardo Almeida, Christopher W Hess, Aparna Wagle Shukla, Kelly D Foote, Michael S Okun, Adolfo Ramirez-Zamora

    Journal of neurology   Vol. 267 ( 5 ) page: 1278 - 1290   2020.5

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    OBJECTIVE: To analyze deep brain stimulation (DBS) outcomes in patients with cervical dystonia (CD), the relationships between motor and disability/pain outcomes, and the differences in outcomes between globus pallidus internus (GPi) and subthalamic nucleus (STN) DBS, and to identify potential outcome predictors. METHODS: A systematic literature search identified individual patient data of CD patients who underwent DBS and whose outcomes were assessed with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Then, we performed a pooled meta-analysis on this cohort. RESULTS: A review of 39 papers yielded 208 patients with individual TWSTRS scores and demographic information. At a mean follow-up period of 23.3 months after either GPi or STN DBS, the TWSTRS total (58.8%), severity (53.9%), disability (61.3%), and pain (46.6%) scores significantly improved compared to baseline status (all p < 0.001). There were no significant outcome differences between short-term (< 23.3 months) and long-term (≥ 23.3 months). The TWSTRS outcomes after GPi and STN DBS were comparable, whereas these two targets showed different adverse effect profiles. The rates of responders to DBS according to the TWSTRS total and severity (defined as ≥ 25% improvement) were both 89%. Regression analyses demonstrated motor benefits associated with disability improvement more than pain relief (R2 = 0.345 and 0.195, respectively). No clinically meaningful predictors for DBS outcomes were identified. CONCLUSION: DBS improves motor symptoms, disability, and pain in CD patients and may provide sustained benefits over 2 years. GPi and STN appear to be equally effective targets with different adverse effect profiles.

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  40. Subjects at risk of Parkinson's disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study. Reviewed International journal

    Makoto Hattori, Takashi Tsuboi, Katsunori Yokoi, Yasuhiro Tanaka, Maki Sato, Keisuke Suzuki, Yutaka Arahata, Akihiro Hori, Motoshi Kawashima, Akihiro Hirakawa, Yukihiko Washimi, Hirohisa Watanabe, Masahisa Katsuno

    Journal of neurology   Vol. 267 ( 5 ) page: 1516 - 1526   2020.5

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    INTRODUCTION: The present study aimed to survey the prevalence of prodromal symptoms of Parkinson's disease (PD) in Japanese health checkup examinees, for identifying at-risk subjects. METHODS: We conducted a questionnaire survey of annual health checkup examinees without neurological symptoms using the following self-reported questionnaires: Japanese version of the Scale for Outcomes in Parkinson's disease for Autonomic Symptoms (SCOPA-AUT); Self-administered Odor Question (SAOQ); REM Sleep Behavior Disorder Screening Scale (RBDSQ); Beck Depression Inventory-Second Edition (BDI-II); Epworth Sleepiness Scale (ESS); and Physical Activity Scale for the Elderly (PASE). The presence of prodromal symptoms was determined using the 90th percentile threshold of each questionnaire. Subjects ≥ 50 years of age with ≥ 2 core prodromal symptoms (dysautonomia, hyposmia, and RBD), were classified as at risk. RESULTS: Between March 2017 and March 2018, 4,953 participants sufficiently answered the questionnaires. Among 2,726 subjects ≥ 50 years of age, 155 were classified as at risk. These subjects had worse values of BDI-II (12.0 ± 8.3 vs. 4.4 ± 3.8, p < 0.001) and ESS (9.6 ± 5.0 vs. 6.3 ± 3.2, p < 0.001), in addition to SCOPA-AUT, SAOQ, and RBDSQ. Male at-risk subjects showed lower values of hemoglobin (14.8 ± 1.3 vs. 15.0 ± 1.1, p = 0.032) and low density lipoprotein cholesterol (114.5 ± 30.3 vs. 123.0 ± 28.9, p = 0.004) than the examinees reporting no prodromal symptoms. CONCLUSION: Approximately 6% of the population aged 50 years or older was at risk for PD. Male at-risk subjects had mild hematological and metabolic changes relevant to PD.

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  41. Functional and Structural Connectivity Patterns Associated with Clinical Outcomes in Deep Brain Stimulation of the Globus Pallidus Internus for Generalized Dystonia Reviewed International coauthorship International journal

    L. Okromelidze, T. Tsuboi, R.S. Eisinger, M.R. Burns, M. Charbel, M. Rana, S.S. Grewal, C.-Q. Lu, L. Almeida, K.D. Foote, M.S. Okun, E.H. Middlebrooks

    American Journal of Neuroradiology   Vol. 41 ( 3 ) page: 508 - 514   2020.3

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    DOI: 10.3174/ajnr.A6429

  42. Hospital Management of Parkinson Disease Patients. Invited Reviewed International coauthorship International journal

    Adolfo Ramirez-Zamora, Takashi Tsuboi

    Clinics in geriatric medicine   Vol. 36 ( 1 ) page: 173 - 181   2020.2

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    Management of patients with Parkinson disease (PD) during inpatient hospital stays is complex and poses unique challenges for physicians and ancillary staff. Patients with PD have a high risk of complications, encephalopathy, and prolonged hospital stay. Early recognition of complications and implementation of rehabilitation strategies along with appropriate management of medications are critical to improve outcomes. Patients with PD can exhibit worsening mobility and balance, insomnia, orthostatic hypotension, multiple neuropsychiatric symptoms, and gastrointestinal dysfunction while hospitalized. This review summarizes the specific in-hospital concerns observed in patients with PD and discusses potential treatment approaches.

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  43. Quality of life outcomes after deep brain stimulation in dystonia: A systematic review. Reviewed International coauthorship International journal

    Takashi Tsuboi, Joshua K Wong, Michael S Okun, Adolfo Ramirez-Zamora

    Parkinsonism & related disorders   Vol. 70   page: 82 - 93   2020.1

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    Dystonia is an incurable movement disorder which can cause not only physical but also mental problems, leading to impaired health-related quality of life (HRQoL). For patients with dystonia refractory to medical treatment, deep brain stimulation (DBS) is a well-established surgical treatment. The objective of this systematic review is to provide a better understanding of HRQoL outcomes after DBS for dystonia. A search of the literature was conducted using Medline (PubMed), Embase, and Cochrane Library databases in May 2019. HRQoL outcomes after DBS along with motor outcomes were reported in a total of 36 articles involving 610 patients: 21 articles on inherited or idiopathic isolated dystonia, 5 on tardive dystonia, 3 on cerebral palsy, 2 on myoclonus-dystonia, 1 on X-linked dystonia-parkinsonism, and 3 on mixed cohorts of different dystonia subtypes. DBS improved motor symptoms in various subtypes of dystonia. Most studies on patients with inherited or idiopathic isolated dystonia showed significant improvement in physical QoL, whereas gains in mental QoL were less robust and likely related to the complexity of associated neuropsychiatric problems. HRQoL outcomes beyond 5 years remain scarce. Although the studies on patients with other subtypes of dystonia also demonstrated improvement in HRQoL after DBS, the interpretation is difficult because of a limited number of articles with small cohorts. Most articles employed generic measures (e.g. Short Form Health Survey-36) and this highlights the critical need to develop and to utilize sensitive and disease-specific HRQoL measures. Finally, long-term HRQoL outcomes and predictors of HRQoL should also be clarified.

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  44. Dysarthria and Speech Intelligibility Following Parkinson's Disease Globus Pallidus Internus Deep Brain Stimulation. Reviewed International journal

    Shannon Y Chiu, Takashi Tsuboi, Karen W Hegland, Nicole E Herndon, Aparna Wagle Shukla, Addie Patterson, Leonardo Almeida, Kelly D Foote, Michael S Okun, Adolfo Ramirez-Zamora

    Journal of Parkinson's disease   Vol. 10 ( 4 ) page: 1493 - 1502   2020

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    BACKGROUND: Although earlier studies reported variable speech changes following subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) patients, the effects of globus pallidus internus (GPi) DBS on speech performance in PD remain largely unknown. OBJECTIVE: We aimed to characterize speech changes following PD GPi-DBS. METHODS: We retrospectively analyzed clinical and speech outcomes of 25 PD patients treated with bilateral GPi-DBS at a single center. Outcome measures included the Unified Parkinson's Disease Rating Scale (UPDRS), speech subsystem domains (respiratory, laryngeal, resonance, orofacial, rate, prosody, rhythm, and naturalness), and overall speech intelligibility. Scores at baseline were compared with those at 6 months, 1 year, and the longest clinical follow-up available. RESULTS: In the off-medication state, activities of daily living and motor function based on UPDRS II and III significantly improved postoperatively. We observed unique patterns of speech changes in patients with PD following GPi-DBS in the short- (n = 25) and longer-term (n = 8) follow-up periods. Velopharyngeal (resonance), laryngeal components, and prosody worsened after bilateral GPi-DBS (p < 0.015). Speech intelligibility did not worsen after GPi-DBS in the short-term, but there was a trend to deteriorate at long-term follow-up (e.g., one year and beyond). We observed worsening of hypokinetic dysarthria in individual patients. Also, a minority of patients developed stuttering, spastic dysarthria, or ataxic dysarthria. CONCLUSION: Bilateral GPi-DBS worsened several modalities of parkinsonian speech without compromising overall speech intelligibility. GPi-DBS can potentially worsen or induce hypokinetic dysarthria, stuttering, spastic dysarthria, or ataxic dysarthria. GPi-DBS may have different and variable effects on speech function when compared to STN-DBS.

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  45. Longitudinal Speech Change After Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease Patients: A 2-Year Prospective Study. Reviewed International journal

    Yasuhiro Tanaka, Takashi Tsuboi, Hirohisa Watanabe, Daisuke Nakatsubo, Satoshi Maesawa, Sachiko Kato, Yasukazu Kajita, Maki Sato, Reiko Oodake, Makoto Hattori, Masahiko Yamamoto, Toshihiko Wakabayashi, Masahisa Katsuno, Gen Sobue

    Journal of Parkinson's disease   Vol. 10 ( 1 ) page: 131 - 140   2020

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    BACKGROUND: Speech disorders are among the most common adverse effects after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients. However, longitudinal speech changes after STN-DBS are not fully understood. OBJECTIVE: We performed a two-year prospective study on PD patients who underwent STN-DBS and analyzed changes in speech function to clarify factors predicting for speech deterioration. METHODS: Twenty-five PD patients were assessed before and up to two years after STN implantation. Speech function was evaluated in the on-stimulation condition and 30 min after stimulation cessation using auditory-perceptual assessment. Patients who experienced overall worsening in speech intelligibility or naturalness ≥1 point during follow-up were classified into a deteriorated group (n = 16), with the remaining subjects being classified into a stable group (n = 9). Cognitive and motor functions were also assessed. RESULTS: The stable group had significantly better values of low volume, monoloudness, and asthenic voice subscores of the auditory-perceptual assessment in the on-stimulation condition compared with the off-stimulation condition. Imprecise consonants, excess loudness variation, and strained voice subscores were improved via cessation of stimulation in both groups. Before surgery, the deteriorated group had significantly lower scores in the Stroop Color-Word Test and Digit Span compared to the stable group. CONCLUSIONS: During follow-up, some subscores showed significant worsening in the on-stimulation condition in both groups. However, beneficial effects of STN-DBS on speech appeared to counterbalance negative effects of STN-DBS on speech function only in the stable group. Worse cognitive function may be a potential predictor for speech deterioration after STN-DBS in PD patients.

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  46. Three-Year Gait and Axial Outcomes of Bilateral STN and GPi Parkinson's Disease Deep Brain Stimulation. Reviewed International coauthorship International journal

    Shanshan Mei, Robert S Eisinger, Wei Hu, Takashi Tsuboi, Kelly D Foote, Christopher J Hass, Michael S Okun, Piu Chan, Adolfo Ramirez-Zamora

    Frontiers in human neuroscience   Vol. 14   page: 1 - 1   2020

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    Objective: To examine the short- and long-term clinical outcomes of the bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on gait and axial symptoms in Parkinson's disease (PD) patients. Available data have been inconsistent and mostly short-term regarding the effect of both brain targets on gait and axial symptoms. We aimed to identify potential target specific differences at 3-year follow-up from a large single-center experience. Methods: We retrospectively reviewed short-term (6-month follow-up) and long-term (36-month follow-up) changes in the Unified Parkinson's Disease Rating Scale (UPDRS) Part II and III total scores of 72 PD patients (53 with bilateral STN-DBS and 19 with bilateral GPi-DBS). An interdisciplinary team made target-specific decisions for each DBS patient. We analyzed changes in gait and axial subscores derived from UPDRS II and III. Results: In both the STN- and GPi-DBS cohorts, we observed no significant differences in gait and axial UPDRS derived subscores in the off-med/on stimulation state at long-term follow-up when compared to baseline. On-med axial scores remained similar in the short-term but worsened in both groups (STN, 2.23 ± 3.43, p < 0.001; GPi, 2.53 ± 2.37, p < 0.01) in the long-term possibly due to disease progression. At long-term follow-up, the UPDRS III off-med/on stimulation scores worsened but were persistently improved from baseline in both groups (-9.07 ± 13.9, p < 0.001). Conclusions: The study showed that long-term both STN- and GPi-DBS had a similar effect on gait and axial symptoms in UPDRS derived subscores at 36-month follow-up despite potential baseline differences in criteria for selection of each target. More sophisticated measures of gait and balance beyond the categorical UPDRS score will be needed for future studies.

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  47. Importance of the initial response to GPi deep brain stimulation in dystonia: A nine year quality of life study. Reviewed International journal

    Takashi Tsuboi, Zakia Jabarkheel, Kelly D Foote, Michael S Okun, Aparna Wagle Shukla

    Parkinsonism & related disorders   Vol. 64   page: 249 - 255   2019.7

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    BACKGROUND: Long-term efficacy of deep brain stimulation (DBS) on health-related quality-of-life (HRQoL) for isolated dystonia is not well established. This study aims to determine the long-term impact of DBS on HRQoL outcomes and identify clinical predictors. METHODS: We retrospectively investigated 16 inherited or idiopathic isolated dystonia patients treated with bilateral globus pallidus internus DBS who were followed beyond 9 years at our center. The cohort consisted of 9 males, 7 females; 10 generalized, 6 segmental; mean (range) age at implantation, 37.0 (8-67) years; mean follow-up duration after implantation, 10.9 (9-13) years. We employed the Unified Dystonia Rating Scale for motor and Short Form Health Survey for HRQoL assessments to monitor the change longitudinally. We analyzed the changes in motor and HRQoL at 1-2 years (short-term) and ≥9 years (long-term) follow-up as compared to baseline with a Wilcoxon signed-rank test. We assessed the factors that predicted motor and HRQoL improvement with univariate regression analyses. RESULTS: Motor (41.6%; p = 0.004) and HRQoL (total score, p = 0.039) improvements remained significant at long-term follow-up and, in the regression analysis, change in HRQoL outcomes correlated significantly with change in motor outcomes (R2 = 0.384, p = 0.010). Additionally, short-term motor and HRQoL improvements predicted the long-term motor (R2 = 0.384, p = 0.010) and HRQoL (total score, R2 = 0.594, p < 0.001) outcomes, respectively. CONCLUSION: Motor and HRQoL improvements with DBS in isolated dystonia remain sustained for nearly a decade and may largely be predictable by the short-term response to DBS.

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  48. Clinical correlates of repetitive speech disorders in Parkinson's disease. Reviewed International journal

    Takashi Tsuboi, Hirohisa Watanabe, Yasuhiro Tanaka, Reiko Ohdake, Maki Sato, Makoto Hattori, Kazuya Kawabata, Kazuhiro Hara, Daisuke Nakatsubo, Satoshi Maesawa, Yasukazu Kajita, Masahisa Katsuno, Gen Sobue

    Journal of the neurological sciences   Vol. 401   page: 67 - 71   2019.6

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    OBJECTIVES: This study aimed to explore clinical correlates of repetitive speech disorders in patients with Parkinson's disease (PD). METHODS: This study investigated speech function (Assessment of Motor Speech for Dysarthria and Stuttering Severity Instrument-3), motor function (Unified Parkinson's Disease Rating Scale III [UPDRS-III] and UPDRS-IV), cognitive function (Mini-Mental State Examination [MMSE], Montreal Cognitive Assessment [MoCA], Stroop color-word test, verbal fluency, digit span tests, and line orientation), and activities of daily living of 113 PD patients. Comparison between groups (independent t-tests, Mann-Whitney U tests, or χ2 test) and linear regression analyses were performed to determine clinical correlates of repetitive speech disorders. RESULTS: Totally, 65 patients (57.5%) had repetitive speech disorders. Patients with repetitive speech disorders had significantly worse UPDRS-III (P = .049), MoCA (P = .030), and speech function and higher levodopa equivalent daily dose (LEDD; P = .031) than those without repetitive speech disorders. Males were significantly predominant in patients with repetitive speech disorders (64.6%) compared to those without repetitive speech disorders (18.7%; P < .001). The univariate and subsequent multiple linear regression analyses revealed that the severity of repetitive speech disorders significantly correlated with gender (P < .001), MoCA (P = .006), and speech variables (abnormal rate, P = .007; imprecise consonants, P = .043), independent from disease duration, UPDRS III, and LEDD. CONCLUSIONS: PD patients with repetitive speech disorders had worse motor, cognitive, and speech functions than those without repetitive speech disorders. The most influential factor for repetitive speech disorders might be male gender.

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  49. Dorsal GPi/GPe Stimulation Induced Dyskinesia in a Patient with Parkinson's Disease.

    Elkouzi A, Tsuboi T, Burns MR, Eisinger RS, Patel A, Deeb W

    Tremor and other hyperkinetic movements (New York, N.Y.)   Vol. 9   2019

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  50. Cabergoline in the Treatment of Parkinson’s Disease Invited Reviewed

    Takashi Tsuboi, Hirohisa Watanabe, Masahisa Katsuno, Gen Sobue

    NeuroPsychopharmacotherapy     page: 1 - 10   2019

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    DOI: 10.1007/978-3-319-56015-1_223-1

  51. 特集 首下がり症候群 錐体外路疾患による首下がり症候群-その病態と分類,治療

    渡辺 宏久, 坪井 崇, 勝野 雅央, 祖父江 元

    脊椎脊髄ジャーナル   Vol. 31 ( 12 ) page: 1042 - 1048   2018.12

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    DOI: 10.11477/mf.5002201012

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  52. 球脊髄性筋萎縮症における前臨床バイオマーカーの変化(Preclinical biomarker changes in spinal and bulbar muscular atrophy)

    Hijikata Yasuhiro, Hashizume Atsushi, Yamada Shinichiro, Inagaki Tomonori, Ito Daisuke, Hirakawa Akihiro, Suzuki Keisuke, Atsuta Naoki, Tsuboi Takashi, Hattori Makoto, Banno Haruhiko, Sobue Gen, Katsuno Masahisa

    臨床神経学   Vol. 58 ( Suppl. ) page: S416 - S416   2018.12

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  53. Corpus callosal involvement is correlated with cognitive impairment in multiple system atrophy. International journal

    Kazuhiro Hara, Hirohisa Watanabe, Epifanio Bagarinao, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Takashi Tsuboi, Mizuki Ito, Naoki Atsuta, Hisayoshi Niwa, Toshiaki Taoka, Satoshi Maesawa, Shinji Naganawa, Masahisa Katsuno, Gen Sobue

    Journal of neurology   Vol. 265 ( 9 ) page: 2079 - 2087   2018.9

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    OBJECTIVE: We examined the anatomical involvement related to cognitive impairment in patients with multiple system atrophy (MSA). METHODS: We examined 30 patients with probable MSA and 15 healthy controls. All MSA patients were assessed by the Unified MSA-Rating scale and Addenbrooke's Cognitive Examination-Revised (ACE-R). We classified 15 MSA patients with ACE-R scores > 88 as having normal cognition (MSA-NC) and 15 with scores ≤ 88 as having cognitive impairment (MSA-CI). All subjects underwent 3 T MRI scanning and were investigated using voxel-based morphometry and diffusion tensor imaging. RESULTS: Both the MSA-NC and MSA-CI patients exhibited cerebellar but not cerebral atrophy in voxel-based morphometry compared to controls. In contrast, tract-based spatial statistics revealed widespread and significantly decreased fractional anisotropy (FA) values, as well as increased mean diffusivity, radial diffusivity, and axial diffusivity in both the cerebrum and cerebellum in MSA-CI patients compared to controls. MSA-NC patients also exhibited similar involvement of the cerebellum but less extensive involvement of the cerebrum compared with the MSA-CI patients. In particular, FA values in MSA-CI patients were significantly decreased in the anterior part of the left corpus callosum compared with those in MSA-NC patients. The mean FA values in the left anterior part of the corpus callosum were significantly correlated with total ACE-R scores and subscores (memory, fluency, and language) in MSA patients. CONCLUSIONS: Decreased FA values in the anterior corpus callosum showed a significant correlation with cognitive impairment in MSA.

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  54. Biomarker-based analysis of preclinical progression in spinal and bulbar muscular atrophy. Reviewed International journal

    Yasuhiro Hijikata, Atsushi Hashizume, Shinichiro Yamada, Tomonori Inagaki, Daisuke Ito, Akihiro Hirakawa, Keisuke Suzuki, Naoki Atsuta, Takashi Tsuboi, Makoto Hattori, Akihiro Hori, Haruhiko Banno, Gen Sobue, Masahisa Katsuno

    Neurology   Vol. 90 ( 17 ) page: E1501 - E1509   2018.4

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    OBJECTIVE: To identify a candidate biomarker reflecting biological changes during the preclinical progression of spinal and bulbar muscular atrophy (SBMA). METHODS: We analyzed longitudinal changes in biochemical parameters obtained during health examinations before and after the diagnosis of SBMA. We estimated trajectories of clinical markers across years from the onset of weakness using linear mixed models and compared these trajectories with those estimated for male healthy controls and patients with amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). Moreover, we examined the relationship between serum creatinine level and the onset of symptoms using Kaplan-Meier curves. RESULTS: Between October 2014 and October 2017, we enrolled 40 patients with genetically confirmed SBMA, 48 healthy controls, 25 patients with ALS, and 20 patients with PD. In patients with SBMA, we evaluated the patients' data for a period of 17.3 ± 7.5 years, including 11.4 ± 7.1 years of preclinical phase. Decreases in serum creatinine occurred >10 years before the onset. The mean serum creatinine concentration was 0.56 mg/dL at the onset of weakness in patients with SBMA compared to 0.88 ± 0.10 mg/dL on final evaluation in healthy controls. Serum levels of alanine transaminase and aspartate transaminase showed tendencies to increase in preclinical SBMA. These preclinical changes of biomarkers were not observed in either ALS or PD. CONCLUSIONS: Our findings suggest that serum creatinine begins to decrease before the onset of clinical symptoms and is a biomarker for disease progression and the efficacy of therapeutics in preclinical SBMA.

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  55. Distinct manifestation of cognitive deficits associate with different resting-state network disruptions in non-demented patients with Parkinson's disease. Reviewed International journal

    Kazuya Kawabata, Hirohisa Watanabe, Kazuhiro Hara, Epifanio Bagarinao, Noritaka Yoneyama, Aya Ogura, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Reiko Ohdake, Yasuhiro Tanaka, Takashi Tsuboi, Tomohiko Nakamura, Masaaki Hirayama, Mizuki Ito, Naoki Atsuta, Satoshi Maesawa, Shinji Naganawa, Masahisa Katsuno, Gen Sobue

    Journal of neurology   Vol. 265 ( 3 ) page: 688 - 700   2018.3

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    Cognitive deficits in Parkinson's disease (PD) are heterogeneous entities, but a relationship between the heterogeneity of cognitive deficits and resting-state network (RSN) changes remains elusive. In this study, we examined five sub-domain scores according to Addenbrooke's Cognitive Examination-Revised (ACE-R) for the cognitive evaluation and classification of 72 non-demented patients with PD. Twenty-eight patients were classified as PD with normal cognition (PD-NC). The remaining 44 were subdivided into the following 2 groups using a hierarchical cluster analysis: 20 with a predominant decrease in memory (PD with amnestic cognitive deficits: PD-A) and 24 with good memory who exhibited a decrease in other sub-domains (PD with non-amnestic cognitive deficits: PD-NA). We used an independent component analysis of RS-fMRI data to investigate the inter-group differences of RSN. Compared to the controls, the PD-A showed lower FC within the ventral default mode network (vDMN) and the visuospatial network. On the other hand, the PD-NA showed lower FC within the visual networks and the cerebellum-brainstem network. Significant differences in the FC within the vDMN and cerebellum-brainstem network were observed between the PD-A and PD-NA, which provided a good discrimination between PD-A and PD-NA using a support vector machine. Distinct patterns of cognitive deficits correspond to different RSN changes.

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  56. Long-standing overt ventriculomegaly without aqueductal stenosis: A case report Reviewed International journal

    Kazuhiro Ikumi, Takashi Tsuboi, Naoki Atsuta, Kazuhito Takeuchi, Haruki Koike, Masahisa Katsuno

    Neurology and Clinical Neuroscience   Vol. 6 ( 2 ) page: 42 - 44   2018.3

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  57. Peritonitis after percutaneous endoscopic gastrojejunostomy for levodopa-carbidopa intestinal gel treatment despite concomitant use of gastropexy Reviewed International journal

    Takashi Tsuboi, Hirohisa Watanabe, Kouhei Funasaka, Mikiko Takebayashi, Kazushi Miyata, Masahisa Katsuno

    Neurology and Clinical Neuroscience   Vol. 6 ( 2 ) page: 64 - 66   2018.3

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  58. Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease. Reviewed International journal

    Noritaka Yoneyama, Hirohisa Watanabe, Kazuya Kawabata, Epifanio Bagarinao, Kazuhiro Hara, Takashi Tsuboi, Yasuhiro Tanaka, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Tatsuya Hattori, Mizuki Ito, Naoki Atsuta, Tomohiko Nakamura, Masaaki Hirayama, Satoshi Maesawa, Masahisa Katsuno, Gen Sobue

    PloS one   Vol. 13 ( 1 ) page: e0190072   2018.1

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    OBJECTIVE: Severe hyposmia is a risk factor of dementia in Parkinson's disease (PD), while the underlying functional connectivity (FC) and brain volume alterations in PD patients with severe hyposmia (PD-SH) are unclear. METHODS: We examined voxel-based morphometric and resting state functional magnetic resonance imaging findings in 15 cognitively normal PD-SH, 15 cognitively normal patients with PD with no/mild hyposmia (PD-N/MH), and 15 healthy controls (HCs). RESULTS: Decreased gray matter volume (GMV) was observed in the bilateral cuneus, right associative visual area, precuneus, and some areas in anterior temporal lobes in PD-SH group compared to HCs. Both the PD-SH and PD-N/MH groups showed increased GMV in the bilateral posterior insula and its surrounding regions. A widespread significant decrease in amygdala FC beyond the decreased GMV areas and olfactory cortices were found in the PD-SH group compared with the HCs. Above all, decreased amygdala FC with the inferior parietal lobule, lingual gyrus, and fusiform gyrus was significantly correlated with both reduction of Addenbrooke's Cognitive Examination-Revised scores and severity of hyposmia in all participants. Canonical resting state networks exhibited decreased FC in the precuneus and left executive control networks but increased FC in the primary and high visual networks of patients with PD compared with HCs. Canonical network FC to other brain regions was enhanced in the executive control, salience, primary visual, and visuospatial networks of the PD-SH. CONCLUSION: PD-SH showed extensive decreased amygdala FC. Particularly, decreased FC between the amygdala and inferior parietal lobule, lingual gyrus, and fusiform gyrus were associated with the severity of hyposmia and cognitive performance. In contrast, relatively preserved canonical networks in combination with increased FC to brain regions outside of canonical networks may be related to compensatory mechanisms, and preservation of brain function.

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  59. Early detection of speech and voice disorders in Parkinson's disease patients treated with subthalamic nucleus deep brain stimulation: a 1-year follow-up study. Reviewed International journal

    Takashi Tsuboi, Hirohisa Watanabe, Yasuhiro Tanaka, Reiko Ohdake, Makoto Hattori, Kazuya Kawabata, Kazuhiro Hara, Mizuki Ito, Yasushi Fujimoto, Daisuke Nakatsubo, Satoshi Maesawa, Yasukazu Kajita, Masahisa Katsuno, Gen Sobue

    Journal of neural transmission (Vienna, Austria : 1996)   Vol. 124 ( 12 ) page: 1547 - 1556   2017.12

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    We previously reported that Parkinson's disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS) had distinct phenotypes of speech and voice disorders: hypokinetic dysarthria, stuttering, breathy voice, strained voice, and spastic dysarthria. However, changes over time remain unclear. In the present study, 32 consecutive PD patients were assessed before and up to 1 year after surgery (PD-DBS). Eleven medically treated PD patients were also assessed (PD-Med). Speech, voice, motor, and cognitive functions were evaluated. At baseline, the incidence of hypokinetic dysarthria (63% of PD-DBS vs. 82% of PD-Med), stuttering (50% vs. 45%), breathy voice (66% vs. 73%), and strained voice (3% vs. 9%) was similar between groups. At 1 year, a slight but significant deterioration in speech intelligibility (p < 0.001) and grade of dysphonia (p = 0.001) were observed only in PD-DBS group compared with baseline. During the follow-up, stuttering (9% vs. 18%) and breathy voice (13% vs. 9%) emerged in PD-DBS and PD-Med, but strained voice (28%) and spastic dysarthria (44%) emerged only in PD-DBS. After the stimulation was stopped, strained voice and spastic dysarthria improved in most patients, while stuttering and breathy voice improved in a minority of patients. These findings indicate that the most common DBS-induced speech and voice disorders are strained voice and spastic dysarthria and that STN-DBS potentially aggravates stuttering and breathy voice. An improved understanding of these types of disorders may help detect speech and voice deteriorations during the early phase and lead to appropriate treatments.

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  60. Corpus callosum involvement by diffusion tensor imaging is early marker of cognitive decline in multiple system atrophy Reviewed International journal

    Hara K., Watanabe H., Bagarinao E., Kawabata K., Yoneyama N., Ohdake R., Imai K., Masuda M., Yokoi T., Tsuboi T., Ito M., Atsuta N., Katsuno M., Sobue G.

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 256 - 256   2017.10

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  61. Early cognitive decline pattern is associated with distinct resting-state networks disruption in non-demented Parkinson's disease patients Reviewed International journal

    Kawabata K., Watanabe H., Hara K., Bagarinao E., Yoneyama N., Ogura A., Imai K., Masuda M., Yokoi T., Ohdake R., Tsuboi T., Ito M., Atsuta N., Katsuno M., Sobue G.

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 128 - 128   2017.10

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  62. Highly asymmetric and subacutely progressive motor weakness with unilateral T2-weighted high intensities along the pyramidal tract in the brainstem in adrenomyeloneuropathy. Reviewed International journal

    Takashi Tsuboi, Yasuhiro Tanaka, Yusuke Yoshida, Tomohiko Nakamura, Nobuyuki Shimozawa, Masahisa Katsuno

    Journal of the neurological sciences   Vol. 381   page: 107 - 109   2017.10

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  63. Instability of syllable repetition in Parkinson's disease after subthalamic nucleus deep brain stimulation Reviewed International journal

    Tanaka Y., Tsuboi T., Watanabe H., Nakatsubo D., Maesawa S., Kajita Y., Hattori M., Ohdake R., Yamamoto M., Wakabatkabayashi T., Katsuno M., Sobue G.

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 1036 - 1036   2017.10

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  64. Longitudinal changes in speech and voice functions after subthalamic nucleus deep brain stimulation in Parkinson's disease patients Reviewed International journal

    Tsuboi, T; Watanabe, H; Tanaka, Y; Ohdake, R; Hattori, M; Kawabata, K; Hara, K; Ito, M; Nakatsubo, D; Maesawa, S; Kajita, Y; Katsuno, M; Sobue, G

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 381   page: 1042 - 1042   2017.10

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  65. Voice and speech treatment of Parkinson's disease

    Tanaka Yasuhiro, Tsuboi Takashi, Levitt June S., Tanaka Mayu, Tanaka Noriyoshi, Watanabe Hirohisa, Katsuno Masahisa

    Journal of allied health sciences   Vol. 8 ( 1 ) page: 80 - 88   2017

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    <p><b>ABSTRACT: </b>Following the Lee Silverman Voice Treatment® program, multiple treatment options became available to address dysphonia, secondary to Parkinson's disease (PD). One of the treatment methods, developed by Elandary and colleagues of the Parkinson Voice Project (a speech clinic solely specialized for PD) in the U.S., takes a unique, two-layer approach. The program starts with a series of one-on-one therapy sessions (SPEAK OUT!®) followed by a group therapy program designed to maintain speech improvements (LOUD Crowd®). With its catchphrase, “Speak with Intent,” the SPEAK OUT!®/LOUD Crowd® program's aim is to activate the pyramidal system that is relatively intact with PD. Two of the authors (YT and NT) recently participated in the SPEAK OUT!®/LOUD Crowd® workshop for clinicians to learn about this new treatment approach. The present report provides the overview of the program as well as a brief summary of other methods that address speech issues for individuals with PD.</p>

    DOI: 10.15563/jalliedhealthsci.8.80

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  66. Active brain changes after initiating fingolimod therapy in multiple sclerosis patients using individual voxel-based analyses for diffusion tensor imaging

    Senda Joe, Watanabe Hirohisa, Endo Kuniyuki, Yasui Keizo, Hawsegawa Yasuhiro, Yoneyama Noritaka, Tsuboi Takashi, Hara Kazuhiro, Ito Mizuki, Atsuta Naoki, Epifanio Bagarinao Jr., Katsuno Masahisa, Naganawa Shinji, Sobue Gen

    Nagoya Journal of Medical Science   Vol. 78 ( 4 ) page: 455 - 463   2016.11

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    Voxel-based analysis (VBA) of diffusion tensor images (DTI) and voxel-based morphometry (VBM) in patients with multiple sclerosis (MS) can sensitively detect occult tissue damage that underlies pathological changes in the brain. In the present study, both at the start of fingolimod and post-four months clinical remission, we assessed four patients with MS who were evaluated with VBA of DTI, VBM, and fluid-attenuated inversion recovery (FLAIR). DTI images for all four patients showed widespread areas of increased mean diffusivity (MD) and decreased fractional anisotropy (FA) that were beyond the highintensity signal areas across images. After four months of continuous fingolimod therapy, DTI abnormalities progressed; in particular, MD was significantly increased, while brain volume and high-intensity signals were unchanged. These findings suggest that VBA of DTI (e.g., MD) may help assess MS demyelination as neuroinflammatory conditions, even though clinical manifestations of MS appear to be in complete remission during fingolimod.

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  67. Articulation Features of Parkinson's Disease Patients with Subthalamic Nucleus Deep Brain Stimulation

    Tanaka Yasuhiro, Tsuboi Takashi, Watanabe Hirohisa, Kajita Yasukazu, Nakatsubo Daisuke, Fujimoto Yasushi, Ohdake Reiko, Ito Mizuki, Atsuta Naoki, Yamamoto Masahiko, Wakabayashi Toshihiko, Katsuno Masahisa, Sobue Gen

    JOURNAL OF PARKINSONS DISEASE   Vol. 6 ( 4 ) page: 811 - 819   2016

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    Background: Voice and speech disorders are one of the most important issues after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients. However, articulation features in this patient population remain unclear. Objective: We studied the articulation features of PD patients with STN-DBS. Methods: Participants were 56 PD patients treated with STN-DBS (STN-DBS group) and 41 patients treated only with medical therapy (medical-therapy-alone group). Articulation function was evaluated with acoustic and auditory-perceptual analyses. The vowel space area (VSA) was calculated using the formant frequency data of three vowels (/a/, /i/, and /u/) from sustained phonation task. The VSA reportedly reflects the distance of mouth/jaw and tongue movements during speech and phonation. Correlations between acoustic and auditory-perceptual measurements were also assessed. Results: The VSA did not significantly differ between the medical-therapy-alone group and the STN-DBS group in the off-stimulation condition. In the STN-DBS group, the VSA was larger in the on-stimulation condition than in the off-stimulation condition. However, individual analysis showed the VSA changes after stopping stimulation were heterogeneous. In total, 89.8 of the STN-DBS group showed a large VSA size in the on- than in the off-stimulation condition. In contrast, the VSA of the remaining patients in that group was smaller in the on- than the off-stimulation condition. Conclusions: STN-DBS may resolve hypokinesia of the articulation structures, including the mouth/jaw and tongue, and improve maximal vowel articulation. However, in the on-stimulation condition, the VSA was not significantly correlated with speech intelligibility. This may be because STN-DBS potentially affects other speech processes such as voice and/or respiratory process.

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  68. Characteristic laryngoscopic findings in Parkinson's disease patients after subthalamic nucleus deep brain stimulation and its correlation with voice disorder

    Tsuboi Takashi, Watanabe Hirohisa, Tanaka Yasuhiro, Ohdake Reiko, Yoneyama Noritaka, Hara Kazuhiro, Ito Mizuki, Hirayama Masaaki, Yamamoto Masahiko, Fujimoto Yasushi, Kajita Yasukazu, Wakabayashi Toshihiko, Sobue Gen

    JOURNAL OF NEURAL TRANSMISSION   Vol. 122 ( 12 ) page: 1663 - 1672   2015.12

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    Speech and voice disorders are one of the most common adverse effects in Parkinson’s disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS). However, the pathophysiology of voice and laryngeal dysfunction after STN-DBS remains unclear. We assessed 47 PD patients (22 treated with bilateral STN-DBS (PD-DBS) and 25 treated medically (PD-Med); all patients in both groups matched by age, sex, disease duration, and motor and cognitive function) using the objective and subjective voice assessment batteries (GRBAS scale and Voice Handicap Index), and laryngoscopy. Laryngoscopic examinations revealed that PD-DBS patients showed a significantly higher incidence of incomplete glottal closure (77 vs 48 %; p = 0.039), hyperadduction of the false vocal folds (73 vs 44 %; p = 0.047), anteroposterior hypercompression (50 vs 20 %; p = 0.030) and asymmetrical glottal movement (50 vs 16 %; p = 0.002) than PD-Med patients. On- and off-stimulation assessment revealed that STN-DBS could induce or aggravate incomplete glottal closure, hyperadduction of the false vocal folds, anteroposterior hypercompression, and asymmetrical glottal movement. Incomplete glottal closure and hyperadduction of the false vocal folds significantly correlated with breathiness and strained voice, respectively (r = 0.590 and 0.539). We should adjust patients’ DBS settings in consideration of voice and laryngeal functions as well as motor function.

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  69. Voice features of Parkinson's disease patients with subthalamic nucleus deep brain stimulation

    Tanaka Yasuhiro, Tsuboi Takashi, Watanabe Hirohisa, Kajita Yasukazu, Fujimoto Yasushi, Ohdake Reiko, Yoneyama Noritaka, Masuda Michihito, Hara Kazuhiro, Senda Joe, Ito Mizuki, Atsuta Naoki, Horiguchi Satoshi, Yamamoto Masahiko, Wakabayashi Toshihiko, Sobue Gen

    JOURNAL OF NEUROLOGY   Vol. 262 ( 5 ) page: 1173 - 1181   2015.5

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    Voice and speech disorders are one of the most important issues after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease patients; however, their characteristics remain unclear. We performed a comprehensive voice evaluation including the multi-dimensional voice program for acoustic analysis, the GRBAS scale for perceptual analysis, and the evaluation of the voice handicap index (VHI) for psychosocial analysis. In total, 68 patients who had undergone STN-DBS (37 assessed in the on- and off-stimulation conditions) and 40 who had been treated with medical therapy alone were evaluated. Further, we performed laryngoscopic examinations in 13 STN-DBS and 19 medical-therapy-alone patients. The STN-DBS group, especially females, showed widespread impairment of voice parameters and significantly poorer VHI scores than the medical-therapy-alone group. The degree of voiceless (DUV) and strained voice were the most impaired factors in the STN-DBS group; and DUV significantly improved after stopping stimulation. Furthermore strained voice, breathiness, and asthenia improved after stopping stimulation. Laryngoscopic examination showed that abnormal laryngeal muscle contraction and incomplete glottal closure were more prominent in the STN-DBS group than in the medical-therapy-alone group. We demonstrated that (1) more widespread voice impairment in females, (2) poorer voice-related QOL, (3) worse DUV and strained voice, and (4) abnormal laryngeal muscle contraction were the characteristic voice and laryngeal findings in the STN-DBS group compared with those in the medical-therapy-alone group.

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  70. Potential of a new MRI for visualizing cerebellar involvement in progressive supranuclear palsy

    Hara Kazuhiro, Watanabe Hirohisa, Ito Mizuki, Tsuboi Takashi, Watanabe Hazuki, Nakamura Ryoichi, Senda Jo, Atsuta Naoki, Adachi Hiroaki, Aiba Ikuko, Naganawa Shinji, Sobue Gen

    PARKINSONISM & RELATED DISORDERS   Vol. 20 ( 2 ) page: 157 - 161   2014.2

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    Objectives: We assessed the usefulness of differential diagnosis of parkinsonism by evaluating lesions of the decussation of the superior cerebellar peduncle (SCP) in patients with progressive supranuclear palsy (PSP) using a new MRI procedure known as readout segmentation of long variable echo-trains (RESOLVE). Methods: We evaluated 100 cases, consisting of 20 with PSP, 24 with Parkinson's disease (PD), 13 with multiple system atrophy with predominant parkinsonism (MSA-P), 18 with multiple system atrophy with predominant cerebellar ataxia (MSA-C), and 24 controls. All patients were scored on the Unified Parkinson's Disease Rating Scale Part III and the Scale for the Assessment and Rating Scale of Ataxia, and MRI using RESOLVE was conducted. Results: Images acquired by this MRI procedure clearly showed high intensity areas corresponding to the decussation of the SCP in all controls, PD, and MSA patients. In contrast, ten of the 20 PSP patients exhibited abnormal iso intensities of the decussation of the SCP, while the other 10 showed high intensity signals. Among the PSP patients, there were no differences in clinical features between those with and those without visualization of the decussation of the SCP. Iso intensity signals had a sensitivity of 50% and a specificity of 100% for differentiating PSP from PD, MSA, and controls. Conclusion: This MRI procedure (RESOLVE) shows a potential for detecting the involvement of the decussation of the SCP in PSP, and can be used for discriminating PSP from PD and MSA-P. © 2013 Elsevier Ltd.

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  71. Cortical and Subcortical Brain Atrophy in Parkinson's Disease With Visual Hallucination

    Watanabe Hirohisa, Senda Jo, Kato Shigenori, Ito Mizuki, Atsuta Naoki, Hara Kazuhiro, Tsuboi Takashi, Katsuno Masahisa, Nakamura Tomohiko, Hirayama Masaaki, Adachi Hiroaki, Naganawa Shinji, Sobue Gen

    MOVEMENT DISORDERS   Vol. 28 ( 12 ) page: 1732 - 1736   2013.10

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    Background: The aim of this study was to investigate the cortical and subcortical brain structures in Parkinson's disease (PD) with visual hallucination (VH), and to elucidate the association between the proposed hypothesis of VH in PD and regional brain volume changes. Methods: We used 3T magnetic resonance imaging (MRI) and voxel-based morphometry (VBM) to investigate the brain structures of PD patients with VH (PD-VH; n=13) and PD patients without VH (PD-C; n=13). Results: The PD-VH patients showed significant cortical atrophy compared to the PD-C patients in the bilateral dorsolateral prefrontal cortex, left rostral region of the prefrontal cortex, left ventral section of the cingulate cortex, bilateral primary visual cortex, and secondary visual cortex including the left inferior occipital gyrus, right lingual cortex, right supramarginal gyrus, and left fusiform gyrus. Significant subcortical atrophic changes were observed in the white matter of the right parahippocampal gyrus, the bilateral posterior part of the cingulate gyrus, the left lingual gyrus, and the right middle occipital gyrus. Conclusions: VH in PD can occur due to distinctive neuroanatomical involvement. © 2013 Movement Disorder Society.

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  72. Cutting-edge MRI techniques for studying neurological diseases focusing on spinocerebellar degeneration

    Watanabe Hirohisa, Senda Joe, Ito Mizuki, Atsuta Naoki, Haram Kazuhiro, Watanabe Hazuki, Nakamura Ryoichi, Tsuboi Takashi, Yoshida Mari, Naganawa Shinji, Sobue Gen

    Rinsho Shinkeigaku   Vol. 53 ( 11 ) page: 1087 - 90   2013

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    This symposium discusses the utility of the different MR techniques in the diagnosis and management of spinocerebellar degeneration (SCD). Conventional MRI is widely used and can show characteristic signal abnormalities such as putaminal hyperintensity, hyperintense putaminal rim, putaminal hypointensity, hot cross bun sign in the pontine base, and hyperintensity in the middle cerebellar peduncles strengthening a diagnosis of multiple system atrophy (MSA). However, the diagnostic utility of these signal abnormalities in early MSA remains restricted. In addition, it should be considered that different magnetic field strengths and sequences could be influenced on the findings resulting false negative. On the other hand, proton magnetic resonance spectroscopy, diffusion weighted imaging (DWI), diffusion tensor imaging (DTI) and voxel based morphometry (VBM) in the pontine base, cerebellum, and putamen will be informative in the early diagnosis of MSA and other SCD prior to conventional MRI changes and even before any clinical manifestation of symptoms. Particularly, DWI, DTI, and VBM are expected to have potential as surrogate markers of disease progression. Further prospective and large studies including earlier disease stages will be needed to clarify whether these novel MR techniques will aid in the future sets of diagnostic criteria and therapeutic trials.

    DOI: 10.5692/clinicalneurol.53.1087

    Scopus

    PubMed

    CiNii Research

  73. MRI mean diffusivity detects widespread brain degeneration in multiple sclerosis

    Senda Joe, Watanabe Hirohisa, Tsuboi Takashi, Hara Kazuhiro, Watanabe Hazuki, Nakamura Ryoichi, Ito Mizuki, Atsuta Naoki, Tanaka Fumiaki, Naganawa Shinji, Sobue Gen

    JOURNAL OF THE NEUROLOGICAL SCIENCES   Vol. 319 ( 1-2 ) page: 105 - 110   2012.8

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    Language:Japanese   Publisher:Journal of the Neurological Sciences  

    We investigated the magnetic resonance imaging (MRI) findings of 32 multiple sclerosis (MS) patients using voxel-based morphometry (VBM) and voxel-based analysis of white matter fluid-attenuated inversion recovery image (FLAIR) high-intensity lesions and diffusion tensor imaging (DTI). Compared with 18 healthy controls, MS patients showed gray matter volume reduction in the thalamus, hypothalamus, caudate, limbic lobe, and frontal lobe. A marked volume reduction of white matter was evident along the ventriculus lateralis and corpus callosum. FLAIR high-intensity lesions were observed beside the ventriculus lateralis. DTI revealed reduced fractional anisotropy areas similar to those of the FLAIR high-intensity lesions. Changes in the volume of increased mean diffusivity (MD) were the most widespread and extended to normal-appearing white matter (p < 0.001). Multiple regression analysis revealed that MD values were significantly correlated with both disease duration (r = 0.381, p = 0.032) and expanded disability status scale scores (EDSS) (r = 0.393, p = 0.026). This study demonstrated that combined voxel-based analysis for volumetry, FLAIR high-intensity lesions, and DTI could reveal widespread brain abnormalities in MS patients. Furthermore, DTI, especially MD, showed far more widespread brain degeneration than other MRI parameters, and was significantly correlated with both severity and disease duration. © 2012 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jns.2012.04.019

    Web of Science

    Scopus

    PubMed

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Books 14

  1. レジデントノート増刊 Vol.25 No.8 救急、プライマリ・ケアでの神経診療がわかる、できる!〜重要疾患を見抜く病歴聴取・神経診察を脳神経内科のエキスパートがやさしく教えます

    坪井崇( Role: Contributor ,  ふるえ)

    羊土社  2023.7  ( ISBN:4758127026

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    Total pages:262   Language:Japanese

    CiNii Books

    ASIN

  2. Cabergoline in the Treatment of Parkinson’s Disease

    Tsuboi T., Watanabe H., Katsuno M., Sobue G.

    NeuroPsychopharmacotherapy  2022.1  ( ISBN:9783030620585

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    Cabergoline, an ergot dopamine agonist with a long elimination half-life, has been proved to be effective for treating Parkinson’s disease (PD) either as monotherapy in de novo patients or as an adjunct to levodopa therapy in patients with advanced PD. Typically, cabergoline is the second choice when patients do not respond adequately to other antiparkinsonian drugs. In the United States, cabergoline is recommended for the treatment of hyperprolactinemic disorders, either idiopathic or because of pituitary adenomas. Clinicians should be aware of the risk of fibrosis, especially of the heart valves. Perhaps, the underlying mechanism for the development of fibrosis is associated with the activation of serotonin receptor subtype 5-HT2B. A meta-analysis reported that the risk of valvular regurgitation increased by 7.25 times in patients with PD taking cabergoline. Additionally, the mean cumulative dose of cabergoline was positively related to the odds ratio concerning valve regurgitation, although the possibility of developing valvular regurgitation is not excluded even with low dose of cabergoline. Thus, regular screening with echocardiography is imperative for the early detection of valvular dysfunction. Furthermore, chest X-rays, urine tests, and blood tests, including erythrocyte sedimentation rate and/or C-reactive protein, should be performed regularly. Currently, the recommended dose of cabergoline is up to 3 mg once daily.

    DOI: 10.1007/978-3-030-62059-2_223

    Scopus

  3. Pergolide in the Treatment of Parkinson’s Disease

    Tsuboi T., Watanabe H., Katsuno M., Sobue G.

    NeuroPsychopharmacotherapy  2022.1  ( ISBN:9783030620585

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    Pergolide, an ergot dopamine agonist with high affinity for dopamine receptors, was first approved as an adjunct to levodopa therapy in patients with Parkinson’s disease (PD) in the United States in 1988. Later, the efficacy of pergolide monotherapy was established for patients with early-stage PD. Since the 2000s, clinicians learned that idiopathic fibrosis, particularly of the heart valves, can be caused by long-term treatment with ergot dopamine agonists. Consequently, pergolide was withdrawn from the US market in 2007. The underlying mechanism for the development of fibrosis was thought to be associated with activation of serotonin receptor subtype 5-HT2B. A meta-analysis reported that the risk of valvular regurgitation increased by 3.05 times in patients with PD taking pergolide. In addition, the mean cumulative dose of pergolide could be positively associated with the odds ratio concerning valvular regurgitation. Nevertheless, pergolide is still used as a treatment for PD in some countries but is considered as a second choice when patients do not respond well to other parkinsonian drugs. The recommended dose for pergolide is up to 3 mg/day, and it should be judiciously used with regular echocardiography, chest X-rays, and urine and blood tests.

    DOI: 10.1007/978-3-030-62059-2_232

    Scopus

  4. パーキンソン病200年 : James Parkinsonの夢

    山本, 光利( Role: Contributor ,  心理的側面:不安・パニック障害)

    中外医学社  2020.1  ( ISBN:9784498328464

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    Total pages:xiv, 424p   Language:Japanese

    CiNii Books

  5. 言語聴覚士のためのパーキンソン病のリハビリテーションガイド : 摂食嚥下障害と発話障害の理解と治療

    杉下, 周平, 福永, 真哉, 田中, 康博(言語聴覚士), 今井, 教仁( Role: Contributor ,  パーキンソン病の概論)

    協同医書出版社  2019.7  ( ISBN:9784763930569

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    Total pages:vii, 150p   Language:Japanese

    CiNii Books

  6. 【首下がり症候群】錐体外路疾患による首下がり症候群 その病態と分類,治療

    渡辺 宏久, 坪井 崇, 勝野 雅央, 祖父江 元

    (株)三輪書店  2018.12 

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    <文献概要>はじめに 首下がり症候群は,体幹に比して頸部が異常に前屈した状態を呈する疾患群を指す(図1).高橋は,「いくつかの基礎疾患に伴ってみられる症候としての首下がり」を首下がり症候群とした.首下がり症候群は,神経筋疾患が原因となる場合,神経変性疾患が原因となる場合,さらには脊椎・脊髄病変が原因となる場合に大別される(図1).一方,"首下がり"は,神経学用語集改訂第3版において,「三浦謹之助が詳述した項部筋不全麻痺による首下がりを主徴とする病態.当初地方病[Gerlier病]とされたが諸原因による」との記載がある.三浦の報告した「Kubisagari」で認めた頸部の前屈は,発作性,麻痺性,再発性で,しばしば家族性であるなど,現在,われわれが診療している首下がり症候群とは臨床像が大きく異なる.このため,目崎は,その総説の中で,dropped headを首下がりと訳すことに対して異を唱えている.この過度の頸部の前屈が,錐体外路疾患において注目されるようになったのは比較的最近であり,用語についてもその成因をジストニアと考えたことに由来するdisproportionate anterocollisや,筋力低下と考えたことに由来するdropped head syndrome(首下がり症候群)が用いられてきた.本レビューでは,錐体外路疾患におけるdisproportionate anterocollis(antecollis)・首下がり症候群の病態,分類,治療について整理したい.

  7. Annual review神経 2018

    後藤, 文男, 柳澤, 信夫, 鈴木, 則宏( Role: Contributor ,  パーキンソン病における発声・発話障害)

    中外医学社  2018.2 

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    Total pages:冊   Language:Japanese

    CiNii Books

  8. 各種疾患 変性疾患 パーキンソン病における発声・発話障害

    坪井 崇, 渡辺 宏久, 祖父江 元, 勝野 雅央

    (株)中外医学社  2018.1 

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    Language:Japanese

  9. 神経疾患治療ストラテジー : 既存の治療・新規治療・今後の治療と考え方

    祖父江, 元( Role: Contributor ,  言語療法)

    中山書店  2017.9  ( ISBN:9784521745435

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    Total pages:xi, 451p   Language:Japanese

    CiNii Books

  10. パーキンソン病における発声・発話治療 般化に向けて

    田中 康博, 坪井 崇, レビット 順子, 田中 まゆ, 田中 教義, 渡辺 宏久, 勝野 雅央

    保健医療学学会  2017.4 

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    パーキンソン病(PD)に対する言語療法はLee Silverman Voice Treatmentが嚆矢となり,その後に病態解明や治療法の開発が進んできた.本稿では,米国のParkinson Voice Project(PD専門の言語治療クリニック)で行われている治療法を中心に紹介する.本施設ではPDにより低下した発声・発話機能の回復を目的とした個別療法と,改善した発声・発話機能の維持を目的とした集団療法の2つの治療プログラムが提供されている.いずれの治療法においてもPD患者が日常生活で良好な発話が保てるよう緻密に構想化されたアプローチのみならず,患者のモチベーションを高めるための創意工夫が随所に施されていた.(著者抄録)

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J06406&link_issn=&doc_id=20170411330011&doc_link_id=%2Fem9allhe%2F2017%2F000801%2F011%2F0080-0088%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fem9allhe%2F2017%2F000801%2F011%2F0080-0088%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  11. 【DBSとrTMSの最近の進歩】DBSに伴う発話障害

    坪井 崇, 渡辺 宏久, 田中 康博, 祖父江 元

    (有)科学評論社  2014.5 

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  12. 【1日1回投与による新時代の幕開け〜徐放型ドパミンアゴニストを用いたパーキンソン病治療戦略〜】難治性運動合併症症例に対する徐放製剤の使用経験 視床下核脳深部刺激術後例におけるロピニロール徐放錠の有用性

    渡辺 宏久, 坪井 崇, 田中 康博, 梶田 泰一, 祖父江 元

    (株)メディカルレビュー社  2013.9 

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    視床下核脳深部刺激療法(STN-DBS)後、長期治療中に再増悪した運動合併症に対し、ロピエロール徐放錠が有効であった2例を経験した。症例1は56歳女で、44歳時に両上肢静止時振戦で発症した。薬物療法の調整は困難と判断し、52歳時に両側STN-DBSを施行した。刺激の調整による運動症状のロントロールは、刺激部位の変更や刺激強度の変更により、ジスキネジアの増悪、複視、手足のしびれなどが出現した。ロピニロール徐放錠へと切り替えたところ、ジスキネジアの増悪を伴うことなく軽度改善した。症例2は54歳女で、38歳時に両上肢静止時振戦で発症した。47歳時に左STN-DBSを施行した。左側への側前屈が増悪したため、ロピニロール徐放錠へと切り替えた。直後は動きの悪化を訴えたが、姿勢異常の軽度から中等度改善を認めた。

  13. 【足の特異な症候】Parkinson病における下肢不随意運動

    渡辺 宏久, 伊藤 瑞規, 坪井 崇, 中村 友彦, 平山 正昭, 祖父江 元

    (株)三輪書店  2013.7 

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  14. 眼で見る神経内科 ビタミンB12補充により臨床症候とMRI画像が改善した亜急性脊髄連合変性症

    坪井 崇, 安藤 哲朗, 川上 治

    (有)科学評論社  2010.5 

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MISC 138

  1. 若手研究者が担う自律神経研究の新時代(臨床編) 心拍変動解析によるパーキンソン病の自律神経障害の検出

    鈴木 将史, 大羽 知里, 畑中 麻衣, 平賀 経太, 玉腰 大悟, 福島 大喜, 植松 高史, 坪井 崇, 平山 正昭, 勝野 雅央

    日本自律神経学会総会プログラム・抄録集   Vol. 76回   page: 73 - 73   2023.10

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  2. 脳深部刺激療法による過剰刺激によりlevodopaが効かなくなるoff症状を呈したパーキンソン病の1例

    福島 大喜, 坪井 崇, 勝野 雅央

    神経治療学   Vol. 40 ( 6 ) page: S233 - S233   2023.10

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    Language:Japanese   Publisher:(一社)日本神経治療学会  

  3. 本態性振戦およびジストニア性振戦の9軸モーションセンサを用いた特徴抽出

    坪井 崇, 澤田 桂都, 星野 聖奈, 樋口 萌花, 武藤 学, 伊藤 芳記, 石崎 友崇, 種井 隆文, 中坪 大輔, 前澤 聡, 鈴木 将史, 佐藤 茉紀, 玉腰 大悟, 平賀 経太, 佐竹 勇紀, 齋藤 竜太, 勝野 雅央

    臨床神経学   Vol. 63 ( Suppl. ) page: S246 - S246   2023.9

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  4. レビー小体病患者・レビー小体病ハイリスク者の嗅覚機能へのNOS-DX1000の有用性の検討

    福島 大喜, 平賀 経太, 玉腰 大悟, 佐竹 勇紀, 服部 誠, 植松 高史, 佐藤 茉紀, 坪井 崇, 勝野 雅央

    臨床神経学   Vol. 63 ( Suppl. ) page: S271 - S271   2023.9

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  5. パーキンソン病のprodromal症状を有する集団における尿中titin濃度の上昇

    佐竹 勇紀, 服部 誠, 平賀 経太, 玉腰 大悟, 坪井 崇, 佐藤 茉紀, 志水 英明, 山本 昌幸, 若井 正一, 勝野 雅央

    臨床神経学   Vol. 63 ( Suppl. ) page: S270 - S270   2023.9

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  6. レビー小体病の非運動症状を有する集団における、レビー小体病前駆期患者検出の試み

    玉腰 大悟, 服部 誠, 佐竹 勇紀, 平賀 経太, 坪井 崇, 佐藤 茉紀, 志水 英明, 山本 昌幸, 若井 正一, 勝野 雅央

    臨床神経学   Vol. 63 ( Suppl. ) page: S271 - S271   2023.9

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  7. レビー小体病患者およびハイリスク者の神経変性関連血液バイオマーカーに関する検討

    平賀 経太, 服部 誠, 佐竹 勇紀, 玉腰 大悟, 坪井 崇, 佐藤 茉紀, 志水 英明, 山本 昌幸, 若井 正一, 横井 克典, 鈴木 啓介, 新畑 豊, 鷲見 幸彦, 中村 昭範, 徳田 隆彦, 勝野 雅央

    臨床神経学   Vol. 63 ( Suppl. ) page: S271 - S271   2023.9

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  8. 脳深部刺激療法による過剰刺激によりoff症状を呈したパーキンソン病の一例

    福島 大喜, 坪井 崇, 勝野 雅央

    臨床神経学   Vol. 63 ( 7 ) page: 478 - 478   2023.7

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  9. 振戦優位型パーキンソン病(TD-PD)におけるMRガイド下集束超音波治療(MRgFUS)の適応判断と治療効果

    中坪 大輔, 津川 隆彦, 加藤 祥子, 前澤 聡, 坪井 崇, 鈴木 将史, 鳥居 潤, 武藤 学, 伊藤 芳記, 若林 俊彦, 勝野 雅央, 齋藤 竜太

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 101 - 101   2023.7

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  10. パーキンソン病のprodromal症状を有する集団での尿中titin濃度とDaT SPECTの関連

    佐竹 勇紀, 服部 誠, 平賀 経太, 玉腰 大悟, 福島 大喜, 坪井 崇, 佐藤 茉紀, 志水 英明, 山本 昌幸, 若井 正一, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 91 - 91   2023.7

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  11. レビー小体病の非運動症状を有する集団における、レビー小体病前駆期患者検出の試み

    玉腰 大悟, 平賀 経太, 佐竹 勇紀, 服部 誠, 坪井 崇, 福島 大喜, 佐藤 茉紀, 志水 英明, 山本 昌幸, 若井 正一, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 108 - 108   2023.7

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  12. レビー小体病患者およびハイリスク者の神経変性関連血液バイオマーカーに関する検討

    平賀 経太, 服部 誠, 佐竹 勇紀, 玉腰 大悟, 福島 大喜, 坪井 崇, 佐藤 茉紀, 志水 英明, 山本 昌幸, 若井 正一, 横井 克典, 鈴木 啓介, 新畑 豊, 鷲見 幸彦, 中村 昭範, 徳田 隆彦, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 76 - 76   2023.7

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  13. レビー小体病患者・レビー小体病ハイリスク者の嗅覚機能評価におけるNOS-DX1000の有用性の検討

    福島 大喜, 平賀 経太, 玉腰 大悟, 佐竹 勇紀, 服部 誠, 植松 高史, 佐藤 茉紀, 生熊 良規, 藤田 修二, 坪井 崇, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 109 - 109   2023.7

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    Language:Japanese   Publisher:Movement Disorder Society of Japan (MDSJ)  

  14. 交感神経負荷によるレム睡眠行動異常症、早期パーキンソン病の心拍変動低下の検出

    鈴木 将史, 大羽 知里, 畑中 麻衣, 坪井 崇, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 109 - 109   2023.7

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  15. 振戦優位型パーキンソン病(TD-PD)におけるMRガイド下集束超音波治療(MRgFUS)の適応判断と治療効果

    中坪 大輔, 津川 隆彦, 加藤 祥子, 前澤 聡, 坪井 崇, 鈴木 将史, 鳥居 潤, 武藤 学, 伊藤 芳記, 若林 俊彦, 勝野 雅央, 齋藤 竜太

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 101 - 101   2023.7

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  16. 脳深部刺激療法による過剰刺激によりoff症状を呈したパーキンソン病の一例

    福島 大喜, 坪井 崇, 勝野 雅央

    臨床神経学   Vol. 63 ( 7 ) page: 478 - 478   2023.7

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  17. パーキンソン病のprodromal症状を有する集団での尿中titin濃度とDaT SPECTの関連

    佐竹 勇紀, 服部 誠, 平賀 経太, 玉腰 大悟, 福島 大喜, 坪井 崇, 佐藤 茉紀, 志水 英明, 山本 昌幸, 若井 正一, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 91 - 91   2023.7

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  18. レビー小体病の非運動症状を有する集団における、レビー小体病前駆期患者検出の試み

    玉腰 大悟, 平賀 経太, 佐竹 勇紀, 服部 誠, 坪井 崇, 福島 大喜, 佐藤 茉紀, 志水 英明, 山本 昌幸, 若井 正一, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 108 - 108   2023.7

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  19. レビー小体病患者およびハイリスク者の神経変性関連血液バイオマーカーに関する検討

    平賀 経太, 服部 誠, 佐竹 勇紀, 玉腰 大悟, 福島 大喜, 坪井 崇, 佐藤 茉紀, 志水 英明, 山本 昌幸, 若井 正一, 横井 克典, 鈴木 啓介, 新畑 豊, 鷲見 幸彦, 中村 昭範, 徳田 隆彦, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 76 - 76   2023.7

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  20. レビー小体病患者・レビー小体病ハイリスク者の嗅覚機能評価におけるNOS-DX1000の有用性の検討

    福島 大喜, 平賀 経太, 玉腰 大悟, 佐竹 勇紀, 服部 誠, 植松 高史, 佐藤 茉紀, 生熊 良規, 藤田 修二, 坪井 崇, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 109 - 109   2023.7

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  21. 交感神経負荷によるレム睡眠行動異常症、早期パーキンソン病の心拍変動低下の検出

    鈴木 将史, 大羽 知里, 畑中 麻衣, 坪井 崇, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 17回   page: 109 - 109   2023.7

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  22. 運動合併症の改善に淡蒼球DBSが有効であったPARK14の1例

    近藤 初, 坪井 崇, 古川 宗磨, 小池 春樹, 中坪 大輔, 前澤 聡, 齋藤 竜太, 勝野 雅央

    臨床神経学   Vol. 63 ( 3 ) page: 182 - 182   2023.3

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  23. 運動合併症の改善に淡蒼球DBSが有効であったPARK14の1例

    近藤 初, 坪井 崇, 古川 宗磨, 小池 春樹, 中坪 大輔, 前澤 聡, 齋藤 竜太, 勝野 雅央

    臨床神経学   Vol. 63 ( 3 ) page: 182 - 182   2023.3

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  24. 特発性血小板減少性紫斑病、好酸球浸潤を呈した硬化性胆管炎を合併し、メポリズマブが奏功した好酸球性多発血管炎性肉芽腫症の1例

    山下 雄太, 武市 拓也, 石津 洋二, 鈴木 伸明, 坪井 崇, 松浦 健太郎, 小泉 遼, 室 慶直, 秋山 真志

    中部リウマチ   Vol. 52 ( 1 ) page: 28 - 28   2023.3

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  25. 振戦優位型パーキンソン病(TD-PD)におけるMRガイド下集束超音波治療(MRgFUS)の適応判断と治療効果の検討

    中坪 大輔, 前澤 聡, 津川 隆彦, 加藤 祥子, 鳥居 潤, 武藤 学, 伊藤 芳記, 坪井 崇, 鈴木 将史, 若林 俊彦, 勝野 雅央, 齊藤 竜太

    日本定位・機能神経外科学会プログラム・抄録集   Vol. 62回   page: 133 - 133   2023.1

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  26. 脳神経内科領域における医学教育の展望 Post/withコロナ時代を見据えて(Vol.15) 大学間連携によるオンライン臨床実習の試み

    吉倉 延亮, 原 一洋, 橋詰 淳, 坪井 崇, 下畑 享良, 勝野 雅央

    BRAIN and NERVE: 神経研究の進歩   Vol. 74 ( 11 ) page: 1309 - 1312   2022.11

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    <文献概要>COVID-19パンデミックは人類と社会に大きなインパクトを与えたが,パンデミック前と比べた最も大きな変化の1つが,オンライン会議システムの普及と活用である。その影響を受けているのは医学も例外ではなく,オンライン診療と並んでオンライン教育の試みも進んでいる。本稿では,東海国立大学機構(名古屋大学と岐阜大学)における脳神経内科領域の合同オンライン臨床実習の試みを紹介する。

  27. 質問紙調査でレビー小体病のprodromal症状を有さない健康診断受診者の臨床的特徴

    平賀 経太, 服部 誠, 佐竹 勇紀, 坪井 崇, 佐藤 茉紀, 志水 英明, 堀 明洋, 若井 正一, 勝野 雅央

    臨床神経学   Vol. 62 ( Suppl. ) page: S282 - S282   2022.10

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  28. 機能的脳神経外科治療が検討された振戦性疾患の診断と治療方針

    坪井 崇, 鈴木 将史, 佐藤 茉紀, 平賀 経太, 佐竹 勇紀, 服部 誠, 原 一洋, 鳥居 潤, 中坪 大輔, 前澤 聡, 斎藤 竜太, 勝野 雅央

    臨床神経学   Vol. 62 ( Suppl. ) page: S256 - S256   2022.10

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  29. パーキンソン病患者における尿中titin濃度の上昇とADLとの関連

    佐竹 勇紀, 服部 誠, 横井 克典, 平賀 経太, 坪井 崇, 佐藤 茉紀, 鷲見 幸彦, 新畑 豊, 鈴木 啓介, 堀 明洋, 勝野 雅央

    臨床神経学   Vol. 62 ( Suppl. ) page: S305 - S305   2022.10

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  30. ALアミロイドーシスに伴うアミロイドミオパチーの1例

    鬼頭 大志, 坪井 崇, 村上 あゆ香, 野田 成哉, 小池 春樹, 勝野 雅央

    神経治療学   Vol. 39 ( 6 ) page: S259 - S259   2022.10

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  31. パーキンソン病患者における尿中titin濃度の上昇とADLとの関連

    佐竹 勇紀, 服部 誠, 横井 克典, 平賀 経太, 坪井 崇, 佐藤 茉紀, 鷲見 幸彦, 新畑 豊, 鈴木 啓介, 堀 明洋, 勝野 雅央

    臨床神経学   Vol. 62 ( Suppl. ) page: S305 - S305   2022.10

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  32. 機能的脳神経外科治療が検討された振戦性疾患の診断と治療方針

    坪井 崇, 鈴木 将史, 佐藤 茉紀, 平賀 経太, 佐竹 勇紀, 服部 誠, 原 一洋, 鳥居 潤, 中坪 大輔, 前澤 聡, 斎藤 竜太, 勝野 雅央

    臨床神経学   Vol. 62 ( Suppl. ) page: S256 - S256   2022.10

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  33. 質問紙調査でレビー小体病のprodromal症状を有さない健康診断受診者の臨床的特徴

    平賀 経太, 服部 誠, 佐竹 勇紀, 坪井 崇, 佐藤 茉紀, 志水 英明, 堀 明洋, 若井 正一, 勝野 雅央

    臨床神経学   Vol. 62 ( Suppl. ) page: S282 - S282   2022.10

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  34. イストラデフィリンの過量服薬が誘因と考えられたdyskinesia-hyperpyrexia syndromeの1例

    小森 祥太, 坪井 崇, 鈴木 将史, 中村 友彦, 勝野 雅央

    臨床神経学   Vol. 62 ( 8 ) page: 627 - 631   2022.8

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    症例は71歳女性.63歳でパーキンソン病を発症し,66歳からウェアリングオフ,その後ジスキネジアも出現した.3日前からジスキネジアの増悪,前日から発熱あり,高クレアチンキナーゼ血症を認め入院.筋強剛を伴わず覚醒中に持続する重度ジスキネジアを認め,dyskinesia-hyperpyrexia syndrome(DHS)と診断した.全身管理と抗パーキンソン病薬の大幅な減量を行い,2週間で改善した.イストラデフィリンの過量服薬がDHSの誘因と考えられた.DHSは稀ではあるが致死的となり得る合併症であり,早期の診断が求められる.治療として,全身管理とともに抗パーキンソン病薬の減量が重要である.(著者抄録)

    Other Link: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01550&link_issn=&doc_id=20220817430006&doc_link_id=10.5692%2Fclinicalneurol.cn-001740&url=https%3A%2F%2Fdoi.org%2F10.5692%2Fclinicalneurol.cn-001740&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  35. 質問紙調査でレビー小体病のprodromal症状を有さない健康診断受診者の臨床的特徴

    平賀 経太, 服部 誠, 佐竹 勇紀, 坪井 崇, 佐藤 茉紀, 志水 英明, 堀 明洋, 若井 正一, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 16回   page: 97 - 97   2022.7

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  36. 9軸モーションセンサによる本態性振戦およびジストニア性振戦の特徴抽出

    坪井 崇, 澤田 桂都, 星野 聖奈, 樋口 萌花, 武藤 学, 鳥居 淳, 中坪 大輔, 前澤 聡, 鈴木 将史, 佐藤 茉紀, 平賀 経太, 佐竹 勇紀, 横井 克典, 服部 誠, 齋藤 竜太, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 16回   page: 91 - 91   2022.7

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  37. パーキンソン病患者における尿中titin濃度とADLとの関連

    佐竹 勇紀, 服部 誠, 横井 克典, 平賀 経太, 坪井 崇, 佐藤 茉紀, 鷲見 幸彦, 新畑 豊, 鈴木 啓介, 堀 明洋, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 16回   page: 101 - 101   2022.7

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  38. 服薬アドヒアランス不良の進行期パーキンソン病に発症したdyskinesia-hyperpyrexia syndromeの1例

    小森 祥太, 坪井 崇, 佐橋 健太郎, 勝野 雅央

    臨床神経学   Vol. 62 ( 3 ) page: 236 - 236   2022.3

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  39. 筋生検が診断の一助となったALアミロイドーシスの1例

    平野 聡子, 坪井 崇, 中村 友彦, 野田 成哉, 小池 春樹, 西田 徹也, 勝野 雅央

    臨床神経学   Vol. 61 ( 11 ) page: 787 - 787   2021.11

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  40. 下肢近位のジストニアによる歩行障害で発症した若年性パーキンソン病の1例

    古川 宗磨, 坪井 崇, 小池 春樹, 勝野 雅央

    臨床神経学   Vol. 61 ( 11 ) page: 773 - 773   2021.11

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  41. パーキンソン病患者の音読と会話の自然言語処理

    横井 克典, 坪井 崇, 服部 誠, 佐竹 勇紀, 平賀 経太, 田中 康博, 佐藤 茉紀, 堀 明洋, 入部 百合絵, 北岡 教英, 鷲見 幸彦, 勝野 雅央

    臨床神経学   Vol. 61 ( Suppl. ) page: S315 - S315   2021.9

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  42. 脳内ネットワークに着目したパーキンソン病と運動障害疾患の病態解明とQOL向上

    坪井 崇

    百年人生におけるパーキンソン病治療の展望   ( 3 ) page: 14 - 15   2021.8

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  43. パーキンソン病患者の音読と会話の自然言語処理

    横井 克典, 坪井 崇, 服部 誠, 佐竹 勇紀, 平賀 経太, 田中 康博, 佐藤 茉紀, 堀 明洋, 入部 百合絵, 北岡 教英, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 15回   page: 81 - 81   2021.7

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  44. 本態性振戦とジストニア性振戦における脳深部刺激療法後の振戦改善効果に関連する脳内ネットワークの相違

    坪井 崇, Wong Joshua, Eisinger Robert, Okromelidze Lela, Burns Mathew, Ramirez-Zamora Adolfo, Almeida Leonardo, Shukla Aparna Wagle, Foote Kelly, Okun Michael, Grewal Sanjeet, 勝野 雅央, Middlebrooks Erik

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 15回   page: 76 - 76   2021.7

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  45. 本態性振戦とジストニア性振戦における脳深部刺激療法後の振戦改善効果に関連する脳内ネットワークの相違

    坪井 崇, Wong Joshua, Eisinger Robert, Okromelidze Lela, Burns Mathew, Ramirez-Zamora Adolfo, Almeida Leonardo, Shukla Aparna Wagle, Foote Kelly, Okun Michael, Grewal Sanjeet, 勝野 雅央, Middlebrooks Erik

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 15回   page: 76 - 76   2021.7

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  46. レビー小体病ハイリスク者コホートの縦断解析

    服部 誠, 横井 克典, 佐竹 勇紀, 平賀 経太, 坪井 崇, 佐藤 茉紀, 川島 基, 堀 明洋, 若井 正一, 鈴木 啓介, 新畑 豊, 鷲見 幸彦, 松川 則之, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 15回   page: 75 - 75   2021.7

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  47. レビー小体病ハイリスク者コホートの縦断解析

    服部 誠, 横井 克典, 佐竹 勇紀, 平賀 経太, 坪井 崇, 佐藤 茉紀, 川島 基, 堀 明洋, 若井 正一, 鈴木 啓介, 新畑 豊, 鷲見 幸彦, 松川 則之, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 15回   page: 75 - 75   2021.7

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  48. パーキンソン病患者の音読と会話の自然言語処理

    横井 克典, 坪井 崇, 服部 誠, 佐竹 勇紀, 平賀 経太, 田中 康博, 佐藤 茉紀, 堀 明洋, 入部 百合絵, 北岡 教英, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 15回   page: 81 - 81   2021.7

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  49. パーキンソン病における淡蒼球脳深部刺激療法後の刺激誘発性ジスキネジアの病態解析

    坪井 崇, Elkouzi Ahmad, Deeb Wissam, Ramirez-Zamora Adolfo, Almeida Leonardo, Zeilman Pamela, Eisinger Robert, Foote Kelly, Okromelidze Lela, Grewal Sanjeet, Okun Michael, Middlebrooks Erik

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 14回   page: 77 - 77   2021.2

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  50. パーキンソン病の小脳萎縮および小脳基底核回路と運動/認知機能との関連

    川畑 和也, 渡辺 宏久, 原 一洋, Bagarinao Epifanio, 大嶽 れい子, 小倉 礼, 桝田 道人, 加藤 隼康, 坪井 崇, 勝野 雅央, 祖父江 元

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 14回   page: 77 - 77   2021.2

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  51. 血清M蛋白を認めなかったPOEMS症候群の1例 診断と治療に関する考察

    鳥居 良太, 土方 靖浩, 坪井 崇, 熱田 直樹, 小池 春樹, 中村 友彦, 勝野 雅央

    神経治療学   Vol. 37 ( 6 ) page: S231 - S231   2020.10

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  52. パーキンソン病の小脳 大脳基底核ネットワークと高次脳機能との関連

    川畑 和也, 渡辺 宏久, バガリナオ・エピファニオ, 大嶽 れい子, 原 一洋, 小倉 礼, 桝田 道人, 加藤 隼康, 坪井 崇, 前澤 聡, 勝野 雅央, 祖父江 元

    Dementia Japan   Vol. 34 ( 4 ) page: 487 - 487   2020.10

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  53. 音節の繰り返しにてリズム異常を認める視床下核脳深部刺激術後のパーキンソン病患者の特徴 小脳疾患との比較 International journal

    田中 康博, 坪井 崇, 渡辺 宏久, 中坪 大輔, 前澤 聡, 加藤 祥子, 佐藤 茉紀, 服部 誠, 横井 克典, 山本 正彦, 勝野 雅央, 祖父江 元

    言語聴覚研究   Vol. 16 ( 3 ) page: 189 - 190   2019.9

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  54. 視床下核脳深部刺激術後のパーキンソン病患者に生じる発話のリズム異常 小脳疾患との比較 International journal

    田中 康博, 坪井 崇, 渡辺 宏久, 中坪 大輔, 前澤 聡, 加藤 祥子, 佐藤 茉紀, 服部 誠, 横井 克典, 山本 正彦, 祖父江 元, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 13回   page: 120 - 120   2019.7

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  55. SNCA点変異を有する家族性パーキンソン病の1例 International journal

    蛭薙 智紀, 坪井 崇, 辻河 高陽, 中村 亮一, 熱田 直樹, 岩井 克成, 勝野 雅央

    臨床神経学   Vol. 59 ( 1 ) page: 46 - 46   2019.1

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  56. 封入体ミオパチーに骨Paget病を合併しmultisystem proteinopathyを疑われた一例 International journal

    原田 祐三子, 村上 あゆ香, 野田 成哉, 木村 正剛, 坪井 崇, 熱田 直樹, 勝野 雅央

    臨床神経学   Vol. 59 ( 1 ) page: 46 - 46   2019.1

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  57. SNCA点変異を有する家族性パーキンソン病の1例

    蛭薙智紀, 坪井崇, 辻河高陽, 中村亮一, 熱田直樹, 岩井克成, 勝野雅央

    臨床神経学(Web)   Vol. 59 ( 1 )   2019

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  58. 【首下がり症候群】錐体外路疾患による首下がり症候群 その病態と分類,治療 International journal

    渡辺 宏久, 坪井 崇, 勝野 雅央, 祖父江 元

    脊椎脊髄ジャーナル   Vol. 31 ( 12 ) page: 1042 - 1048   2018.12

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    <文献概要>はじめに 首下がり症候群は,体幹に比して頸部が異常に前屈した状態を呈する疾患群を指す(図1).高橋は,「いくつかの基礎疾患に伴ってみられる症候としての首下がり」を首下がり症候群とした.首下がり症候群は,神経筋疾患が原因となる場合,神経変性疾患が原因となる場合,さらには脊椎・脊髄病変が原因となる場合に大別される(図1).一方,"首下がり"は,神経学用語集改訂第3版において,「三浦謹之助が詳述した項部筋不全麻痺による首下がりを主徴とする病態.当初地方病[Gerlier病]とされたが諸原因による」との記載がある.三浦の報告した「Kubisagari」で認めた頸部の前屈は,発作性,麻痺性,再発性で,しばしば家族性であるなど,現在,われわれが診療している首下がり症候群とは臨床像が大きく異なる.このため,目崎は,その総説の中で,dropped headを首下がりと訳すことに対して異を唱えている.この過度の頸部の前屈が,錐体外路疾患において注目されるようになったのは比較的最近であり,用語についてもその成因をジストニアと考えたことに由来するdisproportionate anterocollisや,筋力低下と考えたことに由来するdropped head syndrome(首下がり症候群)が用いられてきた.本レビューでは,錐体外路疾患におけるdisproportionate anterocollis(antecollis)・首下がり症候群の病態,分類,治療について整理したい.

    Other Link: https://search.jamas.or.jp/default/link?pub_year=2018&ichushi_jid=J02317&link_issn=&doc_id=20181206110006&doc_link_id=10.11477%2Fmf.5002201012&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.5002201012&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  59. パーキンソン病における視知覚障害の機能的ネットワークの特徴(Functional network features of visuoperceptual disturbances in Parkinson's disease)

    Kawabata Kazuya, Watanabe Hirohisa, Ohdake Reiko, Hara Kazuhiro, Bagarinao Epifanio, Kato Toshiyasu, Ogura Aya, Masuda Michihito, Yokoi Takamasa, Tsuboi Takashi, Katsuno Masahisa, Sobue Gen

    臨床神経学   Vol. 58 ( Suppl. ) page: S203 - S203   2018.12

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  60. 多系統萎縮症において小脳萎縮は認知関連の結合性に影響する(Cerebellar atrophy influence on connectivities related to cognition in multiple system atrophy)

    Hara Kazuhiro, Watanabe Hirohisa, Kawabata Kazuya, Bagarinao Epifanio, Ohdake Reiko, Masuda Michihito, Yokoi Takamasa, Ogura Aya, Tsuboi Takashi, Ito Mizuki, Atsuta Naoki, Niwa Hisayoshi, Taoka Toshiaki, Maesawa Satoshi, Naganawa Shinji, Katsuno Masahisa, Sobue Gen

    臨床神経学   Vol. 58 ( Suppl. ) page: S210 - S210   2018.12

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  61. Tumefactive demyelinatiing lesionsにステロイドパルス療法は有用か? International journal

    深見 祐樹, 岡田 弘明, 山口 啓二, 原田 祐三子, 坪井 崇, 熱田 直樹, 勝野 雅央

    神経治療学   Vol. 35 ( 6 ) page: S222 - S222   2018.11

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  62. めまいを契機に診断された神経核内封入体病の1例 International journal

    岸本 祥之, 坪井 崇, 曽根 淳, 勝野 雅央

    臨床神経学   Vol. 58 ( 11 ) page: 710 - 710   2018.11

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  63. 高度な壊死所見と髄液細胞数増多を伴ったTumefactive demyelinating lesionの一例 International journal

    原田 祐三子, 坪井 崇, 熱田 直樹, 勝野 雅央, 大岡 史治, 竹内 和人

    臨床神経学   Vol. 58 ( 11 ) page: 709 - 709   2018.11

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  64. パーキンソン病患者の発話機能に対して視床下核脳深部刺激術が与える影響 2年の縦断研究 International journal

    田中 康博, 坪井 崇, 渡辺 宏久, 中坪 大輔, 前澤 聡, 加藤 祥子, 服部 誠, 佐藤 茉紀, 原 一洋, 川畑 和也, 山本 正彦, 勝野 雅央, 祖父江 元

    言語聴覚研究   Vol. 15 ( 3 ) page: 214 - 214   2018.9

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  65. 視床下核脳深部刺激術後に発話障害を呈すパーキンソン病患者の臨床背景 2年の縦断研究 International journal

    田中 康博, 坪井 崇, 渡辺 宏久, 中坪 大輔, 前澤 聡, 加藤 祥子, 服部 誠, 佐藤 茉紀, 原 一洋, 川畑 和也, 大嶽 れい子, 山本 正彦, 勝野 雅央, 祖父江 元

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 12回   page: 83 - 83   2018.7

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  66. 健診受診者におけるパーキンソン病(PD)の非運動症状のスコア分布とPD at risk群抽出の試み International journal

    服部 誠, 坪井 崇, 渡辺 宏久, 田中 康博, 川島 基, 堀 明洋, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 12回   page: 88 - 88   2018.7

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  67. 各種疾患 変性疾患 パーキンソン病における発声・発話障害 International journal

    坪井 崇, 渡辺 宏久, 祖父江 元, 勝野 雅央

    Annual Review神経   Vol. 2018   page: 201 - 209   2018.1

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  68. 健診受診者におけるパーキンソン病(PD)の非運動症状のスコア分布とPD at risk群抽出の試み International journal

    服部 誠, 坪井 崇, 渡辺 宏久, 田中 康博, 川島 基, 堀 明洋, 勝野 雅央

    総合健診   Vol. 45 ( 1 ) page: 237 - 237   2018.1

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  69. めまいを契機に診断された神経核内封入体病の1例

    岸本祥之, 坪井崇, 曽根淳, 勝野雅央

    臨床神経学(Web)   Vol. 58 ( 11 )   2018

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  70. パーキンソン病患者の発話機能に対する視床下核脳深部刺激術の影響 縦断的観察研究 International journal

    坪井 崇, 渡辺 宏久, 田中 康博, 大嶽 れい子, 服部 誠, 川畑 和也, 原 一洋, 中坪 大輔, 前澤 聡, 梶田 泰一, 若林 俊彦, 勝野 雅央, 祖父江 元

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 11回   page: 69 - 69   2017.10

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  71. 認知機能低下を示す多系統萎縮症の脳内神経回路解析 International journal

    原 一洋, 渡辺 宏久, 川畑 和也, 大嶽 れい子, 小倉 礼, 横井 孝政, 桝田 道人, 坪井 崇, 伊藤 瑞規, 熱田 直樹, バガリナオ・エピファニオ, 勝野 雅央, 祖父江 元

    Dementia Japan   Vol. 31 ( 4 ) page: 597 - 597   2017.10

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  72. 視床下核脳深部刺激術を施行したパーキンソン病患者における発話の不安定性 International journal

    田中 康博, 坪井 崇, 渡辺 宏久, 中坪 大輔, 前澤 聡, 服部 誠, 加藤 祥子, 大嶽 れい子, 原 一洋, 川畑 和也, 山本 正彦, 勝野 雅央, 祖父江 元

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 11回   page: 77 - 77   2017.10

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  73. 健診受診者におけるパーキンソン病の非運動症状のスコア分布とPD at risk群抽出の試み International journal

    服部 誠, 坪井 崇, 渡辺 宏久, 田中 康博, 川島 基, 堀 明洋, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 11回   page: 71 - 71   2017.10

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  74. 中脳水道狭窄を伴わなかったlong-standing overt ventriculomegaly in adults(LOVA)様水頭症の1例 International journal

    井汲 一尋, 坪井 崇, 田中 康博, 川端 哲平, 秋 禎樹, 永田 雄一, 竹内 和人, 若林 俊彦, 伊藤 瑞規, 勝野 雅央

    臨床神経学   Vol. 57 ( 10 ) page: 613 - 613   2017.10

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  75. 両側声帯麻痺を合併した球脊髄性筋萎縮症1症例の治療経験 International journal

    辻河 高陽, 山田 晋一郎, 橋詰 淳, 坪井 崇, 熱田 直樹, 伊藤 瑞規, 勝野 雅央

    臨床神経学   Vol. 57 ( 10 ) page: 608 - 608   2017.10

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  76. 脳深部刺激調整においてSTが関われること DBSチームの発足 International journal

    田中 康博, 坪井 崇, 渡辺 宏久, 中坪 大輔, 前澤 聡, 加藤 祥子, 伊藤 瑞規, 原 一洋, 川畑 和也, 服部 誠, 山本 正彦, 勝野 雅央, 祖父江 元

    言語聴覚研究   Vol. 14 ( 3 ) page: 196 - 196   2017.9

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  77. 視床下核脳深部刺激術後のパーキンソン病で認める発話のリズム障害 なぜDBS後のPD患者発話はしばしば小脳失調様に聴こえるか? International journal

    田中 康博, 坪井 崇, 渡辺 宏久, 中坪 大輔, 前澤 聡, 加藤 祥子, 大嶽 れい子, 伊藤 瑞規, 原 一洋, 川畑 和也, 服部 誠, 山本 正彦, 勝野 雅央, 祖父江 元

    言語聴覚研究   Vol. 14 ( 3 ) page: 196 - 196   2017.9

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  78. Early cognitive impairment phenotype and functional connectivity in non-demented Parkinson's disease patients

    K. Kawabata, H. Watanabe, K. Hara, E. Bagarinao, N. Yoneyama, A. Ogura, K. Imai, M. Masuda, T. Yokoi, R. Ohdake, T. Tsuboi, M. Ito, N. Atsuta, M. Katsuno, G. Sobue

    MOVEMENT DISORDERS   Vol. 32   2017.6

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    Web of Science

  79. Longitudinal changes in speech and voice functions after subthalamic stimulation in Parkinson's disease patients

    T. Tsuboi, H. Watanabe, Y. Tanaka, R. Ohdake, K. Kawabata, K. Hara, D. Nakatsubo, S. Maesawa, Y. Kajita, T. Wakabayashi, M. Katsuno, G. Sobue

    MOVEMENT DISORDERS   Vol. 32   2017.6

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    Web of Science

  80. パーキンソン病における発声・発話治療 般化に向けて International journal

    田中 康博, 坪井 崇, レビット 順子, 田中 まゆ, 田中 教義, 渡辺 宏久, 勝野 雅央

    保健医療学雑誌   Vol. 8 ( 1 ) page: 80 - 88   2017.4

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    パーキンソン病(PD)に対する言語療法はLee Silverman Voice Treatmentが嚆矢となり,その後に病態解明や治療法の開発が進んできた.本稿では,米国のParkinson Voice Project(PD専門の言語治療クリニック)で行われている治療法を中心に紹介する.本施設ではPDにより低下した発声・発話機能の回復を目的とした個別療法と,改善した発声・発話機能の維持を目的とした集団療法の2つの治療プログラムが提供されている.いずれの治療法においてもPD患者が日常生活で良好な発話が保てるよう緻密に構想化されたアプローチのみならず,患者のモチベーションを高めるための創意工夫が随所に施されていた.(著者抄録)

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J06406&link_issn=&doc_id=20170411330011&doc_link_id=%2Fem9allhe%2F2017%2F000801%2F011%2F0080-0088%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fem9allhe%2F2017%2F000801%2F011%2F0080-0088%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  81. 視床下核脳深部刺激術後のパーキンソン病で認める発話のリズム障害

    田中 康博, 坪井 崇, 渡辺 宏久, 大嶽 れい子, 桝田 道人, 今井 和憲, 伊藤 瑞規, 熱田 直樹, 原 一洋, 川畑 和也, 山本 正彦, 梶田 泰一, 勝野 雅央, 祖父江 元

    臨床神経学   Vol. 56 ( Suppl. ) page: S243 - S243   2016.12

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  82. 両側視床下核脳深部刺激術を施行したパーキンソン病患者における発話機能の縦断的検討

    坪井 崇, 渡辺 宏久, 田中 康博, 大嶽 れい子, 原 一洋, 伊藤 瑞規, 藤本 保志, 梶田 泰一, 勝野 雅央, 祖父江 元

    臨床神経学   Vol. 56 ( Suppl. ) page: S519 - S519   2016.12

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  83. 音素流暢性低下を呈するPD患者における機能的結合の低下(Disruption of functional connectivity in PD patients presenting phonemic fluency impairment)

    Kawabata Kazuya, Watanabe Hirohisa, Bagarinao Epifanio, Hara Kazuhiro, Yoneyama Noritaka, Yokoi Takamasa, Imai Kazunori, Masuda Michihito, Ohdake Reiko, Tsuboi Takashi, Ito Mizuki, Atsuta Naoki, Katsuno Masahisa, Sobue Gen

    臨床神経学   Vol. 56 ( Suppl. ) page: S349 - S349   2016.12

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  84. 認知機能低下を示す多系統萎縮症の脳内ネットワーク解析所見

    原 一洋, 渡辺 宏久, 今井 和憲, 川畑 和也, 大嶽 れい子, 桝田 道人, 坪井 崇, 中村 亮一, 伊藤 瑞規, 熱田 直樹, Bagarinao Epifanio, 勝野 雅央, 祖父江 元

    臨床神経学   Vol. 56 ( Suppl. ) page: S484 - S484   2016.12

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  85. 明日から役立つunmet clinical needsへの対応 パーキンソン病における発声・発話障害

    坪井 崇, 渡辺 宏久, 田中 康博, 中坪 大輔, 前澤 聡, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 10回   page: 63 - 63   2016.10

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  86. 視床下核脳深部刺激がパーキンソン病患者の発話リズムに与える影響

    田中 康博, 坪井 崇, 渡辺 宏久, 大嶽 れい子, 桝田 道人, 今井 和憲, 伊藤 瑞規, 熱田 直樹, 原 一洋, 川畑 和也, 梶田 泰一, 勝野 雅央, 祖父江 元

    言語聴覚研究   Vol. 13 ( 3 ) page: 196 - 196   2016.9

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  87. Brain network imaging findings in multiple system atrophy with cognitive decline

    K. Hara, H. Watanabe, E. Bagarinao, K. Kawabata, N. Yoneyama, R. Ohdake, K. Imai, M. Masuda, T. Yokoi, T. Tsuboi, M. Ito, N. Atsuta, M. Katsuno, G. Sobue

    MOVEMENT DISORDERS   Vol. 31   page: S373 - S373   2016.6

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  88. Disruption of functional connectivity in Parkinson's disease patients presenting phonemic fluency impairment

    K. Kawabata, H. Watanabe, E. Bagarinao, N. Yoneyama, K. Hara, R. Ohdake, K. Imai, M. Masuda, T. Yokoi, T. Tsuboi, M. Ito, N. Atsuta, M. Katsuno, G. Sobue

    MOVEMENT DISORDERS   Vol. 31   page: S394 - S394   2016.6

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  89. Longitudinal changes of speech and voice disorders following subthalamic stimulation in Parkinson's disease patients

    T. Tsuboi, H. Watanabe, Y. Tanaka, R. Ohdake, K. Kawabata, K. Hara, M. Ito, M. Hirayama, Y. Fujimoto, Y. Kajita, M. Katsuno, G. Sobue

    MOVEMENT DISORDERS   Vol. 31   page: S6 - S6   2016.6

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  90. 視床下核脳深部刺激術後のパーキンソン病患者における構音動態

    田中 康博, 坪井 崇, 渡辺 宏久, 梶田 泰一, 藤本 保志, 大嶽 れい子, 桝田 道人, 今井 和憲, 伊藤 瑞規, 原 一洋, 山本 正彦, 勝野 雅央, 祖父江 元

    音声言語医学   Vol. 57 ( 1 ) page: 78 - 78   2016.1

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  91. 視床下核脳深部刺激術後のパーキンソン病患者における発声障害と喉頭機能異常の検討

    坪井 崇, 渡辺 宏久, 田中 康博, 大嶽 れい子, 原 一洋, 米山 典孝, 伊藤 瑞規, 藤本 保志, 梶田 泰一, 祖父江 元

    臨床神経学   Vol. 55 ( Suppl. ) page: S315 - S315   2015.12

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  92. パーキンソン病における重度嗅覚低下と安静時脳機能MRIの検討

    米山 典孝, 渡辺 宏久, 原 一洋, 川畑 和也, 平山 正昭, 今井 和憲, 坪井 崇, 桝田 道人, 横井 大知, 渡辺 はづき, 熱田 直樹, 伊藤 瑞規, 田中 康博, 大嶽 れい子, 祖父江 元

    臨床神経学   Vol. 55 ( Suppl. ) page: S432 - S432   2015.12

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  93. tract-based spatial statisticsを用いた多系統萎縮症の画像解析

    原 一洋, 渡辺 宏久, 今井 和憲, 川畑 和也, 米山 典孝, 桝田 道人, 坪井 崇, 渡邉 はづき, 中村 亮一, 伊藤 瑞規, 熱田 直樹, バガリナオ・エピファニオ・ジュニア, 辻河 高陽, 加藤 重典, 安井 敬三, 長谷川 康博, 祖父江 元

    臨床神経学   Vol. 55 ( Suppl. ) page: S257 - S257   2015.12

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  94. MMSEが正常のパーキンソン病に対するACE-Rを用いた高次機能の検討

    川畑 和也, 渡辺 宏久, 米山 典孝, 原 一洋, 大嶽 れい子, 田中 康博, 坪井 崇, 渡辺 はづき, 中村 亮一, 伊藤 瑞規, 熱田 直樹, 祖父江 元

    臨床神経学   Vol. 55 ( Suppl. ) page: S431 - S431   2015.12

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  95. 音響分析を用いた視床下核脳深部刺激術後のパーキンソン病患者の構音動態

    田中 康博, 坪井 崇, 渡辺 宏久, 梶田 泰一, 大嶽 れい子, 桝田 道人, 今井 和憲, 伊藤 瑞規, 熱田 直樹, 原 一洋, 川畑 和也, 藤本 保志, 山本 正彦, 勝野 雅央, 祖父江 元

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 9回   page: 95 - 95   2015.10

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  96. 早期運動合併症をもつパーキンソン病2症例における淡蒼球内節脳深部刺激療法の臨床効果

    坪井 崇, 渡辺 宏久, 田中 康博, 川畑 和也, 梶田 泰一, 祖父江 元, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 9回   page: 94 - 94   2015.10

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  97. MMSEが正常のパーキンソン病におけるACE-Rを用いた高次脳機能障害の特徴

    川畑 和也, 渡辺 宏久, 米山 典孝, 原 一洋, 横井 孝政, 今井 和憲, 桝田 道人, 大嶽 れい子, 田中 康博, 坪井 崇, 横井 大知, 中村 亮一, 伊藤 瑞規, 熱田 直樹, 祖父江 元, 勝野 雅央

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 9回   page: 101 - 101   2015.10

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  98. Delayed Auditory Feedbackの使用にて劇的に発話の明瞭性が改善したPSP例

    田中 康博, 渡辺 宏久, 坪井 崇, 桝田 道人, 今井 和憲, 大嶽 れい子, 原 一洋, 伊藤 瑞規, 勝野 雅央, 祖父江 元

    神経治療学   Vol. 32 ( 5 ) page: 797 - 797   2015.9

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  99. 淡蒼球内節脳深部刺激術が有効であった頸部ジストニアと早期運動合併症を併存したパーキンソン病の1例

    坪井 崇, 渡辺 宏久, 田中 康博, 梶田 泰一, 祖父江 元

    神経治療学   Vol. 32 ( 5 ) page: 763 - 763   2015.9

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  100. MMSEが正常のパーキンソン病におけるACE-Rを用いた高次脳機能障害の特徴

    川畑 和也, 渡辺 宏久, 米山 典孝, 原 一洋, 横井 孝政, 今井 和憲, 桝田 道人, 大嶽 れい子, 田中 康博, 坪井 崇, 横井 大知, 中村 亮一, 伊藤 瑞規, 熱田 直樹, 勝野 雅央, 祖父江 元

    神経治療学   Vol. 32 ( 5 ) page: 809 - 809   2015.9

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  101. 運動失調症の医療基盤に関する調査研究 多系統萎縮症の脳内神経回路解析

    祖父江元, 原一洋, 今井和憲, 川畑和也, 米山典孝, 桝田道人, 坪井崇, 渡邉はづき, 中村亮一, 伊藤瑞規, 熱田直樹, 渡辺宏久, エピファニオジュニア バガリナオ, 辻河高陽, 加藤重典, 安井敬三, 長谷川康博

    運動失調症の医療基盤に関する調査研究 平成26年度 総括・分担研究報告書     2015

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  102. 筋萎縮性側索硬化症と前頭側頭型認知症はMRIにて共通の皮質・皮質下病変を有する

    渡辺 宏久, 千田 譲, 桝田 道人, 陸 雄一, 勝野 雅央, 石垣 診祐, 熱田 直樹, 伊藤 瑞規, 中村 亮一, 渡辺 はづき, 原 一洋, 坪井 崇, 米山 典孝, 長縄 慎二, 祖父江 元

    臨床神経学   Vol. 54 ( Suppl. ) page: S70 - S70   2014.12

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  103. 脳容積・拡散テンソル測定を用いた筋萎縮性側索硬化症の症状進行予測

    千田 譲, 陸 雄一, 桝田 道人, 坪井 崇, 原 一洋, 中村 亮一, 渡辺 はづき, 伊藤 瑞規, 熱田 直樹, 渡辺 宏久, 長縄 慎二, 祖父江 元

    臨床神経学   Vol. 54 ( Suppl. ) page: S22 - S22   2014.12

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  104. 視床下核脳深部刺激療法後に認めたパーキンソン病の音声障害の解析

    米山 典孝, 田中 康博, 渡辺 宏久, 坪井 崇, 藤本 保志, 梶田 泰一, 大嶽 れい子, 桝田 道人, 原 一洋, 渡辺 はづき, 千田 譲, 熱田 直樹, 伊藤 瑞規, 堀口 利之, 祖父江 元

    臨床神経学   Vol. 54 ( Suppl. ) page: S192 - S192   2014.12

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  105. 両側視床下核脳深部刺激術後のパーキンソン病患者における言語障害の解析

    坪井 崇, 田中 康博, 大嶽 れい子, 原 一洋, 中村 亮一, 渡辺 はづき, 千田 譲, 熱田 直樹, 伊藤 瑞規, 渡辺 宏久, 藤本 保志, 梶田 泰一, 祖父江 元

    臨床神経学   Vol. 54 ( Suppl. ) page: S6 - S6   2014.12

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  106. MRI脳容積・拡散テンソル画像を用いた前頭側頭型認知症における大脳病変の解析

    桝田 道人, 陸 雄一, 坪井 崇, 原 一洋, 渡辺 はずき, 中村 亮一, 千田 譲, 伊藤 瑞規, 熱田 直樹, 渡辺 宏久, 祖父江 元

    臨床神経学   Vol. 54 ( Suppl. ) page: S185 - S185   2014.12

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  107. 視床下核脳深部刺激療法後におけるパーキンソン病患者の音声特徴 音声の多面的評価より

    田中 康博, 渡辺 宏久, 坪井 崇, 藤本 保志, 梶田 泰一, 大嶽 れい子, 桝田 道人, 米山 典孝, 原 一洋, 千田 譲, 熱田 直樹, 伊藤 瑞規, 堀口 利之, 祖父江 元

    パーキンソン病・運動障害疾患コングレスプログラム・抄録集   Vol. 8回   page: 68 - 68   2014.10

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  108. 視床下核脳深部刺激術後のパーキンソン病患者の構音運動

    田中 康博, 渡辺 宏久, 坪井 崇, 大嶽 れい子, 桝田 道人, 千田 譲, 伊藤 瑞規, 熱田 直樹, 米山 典孝, 梶田 泰一, 山本 正彦, 辰巳 寛, 祖父江 元

    言語聴覚研究   Vol. 11 ( 3 ) page: 263 - 263   2014.9

  109. 淡蒼球内節脳深部刺激術(GPi-DBS)を施行した全身性ジストニア例における発話の変化

    大嶽 れい子, 田中 康博, 渡辺 宏久, 坪井 崇, 米山 典孝, 桝田 道人, 原 一洋, 中村 亮一, 渡辺 はづき, 千田 譲, 伊藤 瑞規, 熱田 直樹, 辰巳 寛, 梶田 泰一, 祖父江 元

    言語聴覚研究   Vol. 11 ( 3 ) page: 193 - 193   2014.9

  110. 【DBSとrTMSの最近の進歩】DBSに伴う発話障害

    坪井 崇, 渡辺 宏久, 田中 康博, 祖父江 元

    神経内科   Vol. 80 ( 5 ) page: 547 - 554   2014.5

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  111. 椎骨動脈の延髄圧迫により神経症状をきたした2症例

    川畑 和也, 熱田 直樹, 高橋 美江, 坪井 崇, 荒木 周, 伊藤 瑞規, 祖父江 元

    臨床神経学   Vol. 54 ( 3 ) page: 270 - 270   2014.3

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  112. 視床下核脳深部刺激術後のパーキンソン病患者の音声特徴

    田中 康博, 渡辺 宏久, 坪井 崇, 藤本 保志, 梶田 泰一, 大嶽 れい子, 桝田 道人, 原 一洋, 渡辺 はづき, 千田 譲, 熱田 直樹, 伊藤 瑞規, 堀口 利之, 祖父江 元

    音声言語医学   Vol. 55 ( 1 ) page: 66 - 66   2014.1

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  113. 病理学的にTDP-43 proteinopathyが確認された237剖検例の自然歴の検討

    渡辺 宏久, 陸 雄一, 熱田 直樹, 伊藤 瑞規, 千田 譲, 中村 亮一, 渡辺 はづき, 原 一洋, 坪井 崇, 岩崎 靖, 三室 マヤ, 辰己 新水, 吉田 眞理, 祖父江 元

    臨床神経学   Vol. 53 ( 12 ) page: 1554 - 1554   2013.12

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  114. 脳容積・拡散テンソルVBA MRI画像による前頭側頭葉変性症大脳病変の特徴

    桝田 道人, 陸 雄一, 坪井 崇, 原 一洋, 渡辺 はづき, 中村 亮一, 千田 譲, 伊藤 瑞規, 熱田 直樹, 渡辺 宏久, 祖父江 元

    臨床神経学   Vol. 53 ( 12 ) page: 1606 - 1606   2013.12

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  115. 筋萎縮性側索硬化症の大脳病変 脳容積・拡散テンソルを用いた検討

    千田 譲, 陸 雄一, 桝田 道人, 坪井 崇, 原 一洋, 中村 亮一, 渡辺 はづき, 伊藤 瑞規, 熱田 直樹, 渡辺 宏久, 長縄 慎二, 祖父江 元

    臨床神経学   Vol. 53 ( 12 ) page: 1438 - 1438   2013.12

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    Language:Japanese   Publisher:(一社)日本神経学会  

  116. 視床下核脳深部刺激術後のパーキンソン病患者における言語障害の解析

    坪井 崇, 渡辺 宏久, 田中 康博, 大嶽 れい子, 伊藤 瑞規, 千田 譲, 原 一洋, 藤本 保志, 梶田 泰一, 祖父江 元

    臨床神経学   Vol. 53 ( 12 ) page: 1558 - 1558   2013.12

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  117. RESOLVEを用いた進行性核上性麻痺における上小脳脚病変の検討

    原 一洋, 伊藤 瑞規, 坪井 崇, 渡辺 はづき, 中村 亮一, 千田 譲, 熱田 直樹, 渡辺 宏久, 饗場 郁子, 長縄 慎二, 祖父江 元

    臨床神経学   Vol. 53 ( 12 ) page: 1433 - 1433   2013.12

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  118. 運動機能障害を認めない多系統萎縮症の臨床病理学的検討

    土方 靖浩, 渡辺 宏久, 陸 雄一, 伊藤 瑞規, 熱田 直樹, 千田 譲, 原 一洋, 坪井 崇, 岩崎 靖, 三室 マヤ, 辰己 新水, 吉田 眞理, 祖父江 元

    臨床神経学   Vol. 53 ( 12 ) page: 1466 - 1466   2013.12

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  119. 病態と患者ニーズに基づいた筋萎縮性側索硬化症における拡大・代替コミュニケーション導入の工夫 高度球麻痺型症例の経験を通じて

    大嶽 れい子, 田中 康博, 桝田 道人, 渡辺 宏久, 伊藤 瑞規, 熱田 直樹, 千田 譲, 中村 亮一, 渡辺 はづき, 坪井 崇, 原 一洋, 岡田 暁典, 祖父江 元

    言語聴覚研究   Vol. 10 ( 3 ) page: 245 - 245   2013.9

  120. 【1日1回投与による新時代の幕開け〜徐放型ドパミンアゴニストを用いたパーキンソン病治療戦略〜】難治性運動合併症症例に対する徐放製剤の使用経験 視床下核脳深部刺激術後例におけるロピニロール徐放錠の有用性

    渡辺 宏久, 坪井 崇, 田中 康博, 梶田 泰一, 祖父江 元

    Pharma Medica   Vol. 31 ( 9 ) page: 187 - 191   2013.9

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    視床下核脳深部刺激療法(STN-DBS)後、長期治療中に再増悪した運動合併症に対し、ロピエロール徐放錠が有効であった2例を経験した。症例1は56歳女で、44歳時に両上肢静止時振戦で発症した。薬物療法の調整は困難と判断し、52歳時に両側STN-DBSを施行した。刺激の調整による運動症状のロントロールは、刺激部位の変更や刺激強度の変更により、ジスキネジアの増悪、複視、手足のしびれなどが出現した。ロピニロール徐放錠へと切り替えたところ、ジスキネジアの増悪を伴うことなく軽度改善した。症例2は54歳女で、38歳時に両上肢静止時振戦で発症した。47歳時に左STN-DBSを施行した。左側への側前屈が増悪したため、ロピニロール徐放錠へと切り替えた。直後は動きの悪化を訴えたが、姿勢異常の軽度から中等度改善を認めた。

  121. 急速に発話機能の改善を認めた視床下核脳深部刺激術後のパーキンソン病患者の1例

    田中 康博, 坪井 崇, 渡辺 宏久, 大嶽 れい子, 桝田 道人, 伊藤 瑞規, 熱田 直樹, 千田 譲, 中村 亮一, 渡辺 はづき, 原 一洋, 梶田 泰一, 藤本 保志, 祖父江 元

    言語聴覚研究   Vol. 10 ( 3 ) page: 186 - 186   2013.9

  122. 【足の特異な症候】 Parkinson病における下肢不随意運動 Reviewed

    渡辺 宏久, 伊藤 瑞規, 坪井 崇, 中村 友彦, 平山 正昭, 祖父江 元

    脊椎脊髄ジャーナル   Vol. 26 ( 7 ) page: 747-751 - 751   2013.7

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    Language:Japanese   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Publisher:(株)三輪書店  

  123. 筋萎縮性側索硬化症に対する脳容積・拡散テンソルVoxel-Based Analysis法を用いた検討

    千田 譲, 坪井 崇, 原 一洋, 中村 亮一, 渡辺 はづき, 伊藤 瑞規, 熱田 直樹, 渡辺 宏久, 長縄 慎二, 祖父江 元

    臨床神経学   Vol. 52 ( 12 ) page: 1446 - 1446   2012.12

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  124. 視床下核脳深部刺激術後のパーキンソン病患者における言語障害の解析

    坪井 崇, 田中 康博, 原 一洋, 伊藤 瑞規, 渡辺 宏久, 祖父江 元, 前澤 聡, 中坪 大輔, 梶田 泰一

    臨床神経学   Vol. 52 ( 12 ) page: 1507 - 1507   2012.12

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  125. 幻視を呈するパーキンソン病におけるvoxel based morphometry所見

    渡辺 宏久, 千田 譲, 加藤 重典, 伊藤 瑞規, 熱田 直樹, 渡辺 はづき, 原 一洋, 坪井 崇, 中村 亮一, 長縄 慎二, 祖父江 元

    臨床神経学   Vol. 52 ( 12 ) page: 1550 - 1550   2012.12

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  126. 多系統萎縮症におけるvolumetry・拡散テンソル画像を用いた大脳病変の広がり

    伊藤 瑞規, 渡辺 宏久, 千田 譲, 熱田 直樹, 中村 亮一, 渡辺 はづき, 原 一洋, 坪井 崇, 長縄 慎二, 祖父江 元

    臨床神経学   Vol. 52 ( 12 ) page: 1441 - 1441   2012.12

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  127. Resolve法を用いた進行性核上性麻痺における上小脳脚病変の検討

    原 一洋, 渡辺 宏久, 坪井 崇, 渡邉 はづき, 中村 亮一, 千田 譲, 伊藤 瑞規, 熱田 直樹, 饗場 郁子, 長縄 慎二, 祖父江 元

    臨床神経学   Vol. 52 ( 12 ) page: 1441 - 1441   2012.12

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  128. Resolve法を用いた進行性核上性麻痺(PSP)の脳幹病変の検討

    原 一洋, 渡辺 宏久, 坪井 崇, 千田 譲, 伊藤 瑞規, 熱田 直樹, 長縄 慎二, 祖父江 元

    臨床神経学   Vol. 51 ( 10 ) page: 804 - 804   2011.10

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  129. PET-CTで特徴的な所見を呈し、ステロイド治療で改善を認めたサルコイドミオパチーの1例

    坪井 崇, 中西 浩隆, 曽根 淳, 松尾 幸治, 木村 正剛, 渡辺 宏久, 祖父江 元

    神経治療学   Vol. 28 ( 5 ) page: 545 - 545   2011.9

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  130. 明らかな筋力低下を認めなかったDysferlinopathy3例の臨床・電気生理学的特徴

    坪井 崇, 中西 浩隆, 松尾 幸治, 渡辺 宏久, 祖父江 元, 朝倉 邦彦, 武藤 多津郎, 伊藤 慶太

    臨床神経学   Vol. 51 ( 9 ) page: 722 - 722   2011.9

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  131. 筋MRI、PET-CTで特徴的な所見を呈したサルコイドミオパチーの一例

    坪井 崇, 中西 浩隆, 曽根 淳, 松尾 幸治, 木村 正剛, 渡辺 宏久, 祖父江 元

    臨床神経学   Vol. 51 ( 6 ) page: 449 - 449   2011.6

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  132. ビタミンB12補充療法により臨床症候とMRI画像が改善した亜急性脊髄連合変性症の一例

    坪井 崇, 安井 哲朗, 川上 治

    臨床神経学   Vol. 51 ( 4 ) page: 297 - 297   2011.4

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  133. 左半身の異常感覚を呈するFisher症候群を再発した一例

    犬塚 円, 安藤 哲朗, 川上 治, 杉浦 真, 加藤 博子, 土方 靖浩, 坪井 崇, 鈴木 将史

    臨床神経学   Vol. 51 ( 4 ) page: 293 - 293   2011.4

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  134. PET-CTが診断に有用であった顎下腺腺様嚢胞癌の浸潤によるVillaret症候群の一例

    坪井 崇, 安藤 哲朗, 三矢 昭治, 祖父江 元

    臨床神経学   Vol. 50 ( 10 ) page: 749 - 749   2010.10

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  135. 眼で見る神経内科 ビタミンB12補充により臨床症候とMRI画像が改善した亜急性脊髄連合変性症

    坪井 崇, 安藤 哲朗, 川上 治

    神経内科   Vol. 72 ( 5 ) page: 541 - 542   2010.5

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  136. 脊髄梗塞と脳梗塞を同時発症した高度椎骨動脈狭窄例

    鈴木 将史, 安藤 哲朗, 川上 治, 杉浦 真, 加藤 博子, 土方 靖浩, 坪井 崇, 犬塚 円

    臨床神経学   Vol. 50 ( 2 ) page: 115 - 115   2010.2

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  137. 脳梗塞を契機に発見された原発性アルドステロン症の1症例

    坪井 崇, 安藤 哲朗, 川上 治, 杉浦 真, 加藤 博子, 土方 靖浩, 鈴木 将史, 犬塚 円

    臨床神経学   Vol. 50 ( 2 ) page: 116 - 116   2010.2

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  138. リチウム中毒による意識障害の一症例

    土方 靖浩, 安藤 哲朗, 川上 治, 杉浦 真, 加藤 博子, 坪井 崇, 鈴木 将史, 犬塚 円

    臨床神経学   Vol. 50 ( 2 ) page: 121 - 121   2010.2

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Presentations 22

  1. パーキンソン病の脳ネットワーク Invited

    坪井崇

    The 23rd Takamatsu International Symposium for PD and MD  2024.3.16 

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    Event date: 2024.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  2. 3D-accelerometry characteristics of essential tremor and dystonic tremor

    Takashi Tsuboi, Keito Sawada, Sena Hoshino, Moeka Higuchi, Manabu Mutoh, Yoshiki Ito, Daisuke Nakatsubo, Tomotaka Ishizaki, Takafumi Tanei, Satoshi Maesawa, Maki Sato, Daigo Tamakoshi, Takashi Uematsu, Keita Hiraga, Yuki Satake, Masashi Suzuki, Ryuta Saito, Masahisa Katsuno

    International Congress of Parkinson’s Disease and Movement Disorders  2023.8.23 

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    Event date: 2023.8

    Language:English   Presentation type:Poster presentation  

  3. Local field potentials detected from deep brain stimulation electrodes for Parkinson’s Disease Japan cohort study

    Nagako Murase, Hideo Mure, Hideki Oshima, Katsuo Kimura, Haruhiko Kishima, Yoshio Tsuboi, Takashi Tsuboi, Tatsuya Takezaki, Yoshinori Higuchi, Genko Oyama

    2023.11.30 

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    Event date: 2023.11 - 2023.12

  4. Local field potential characteristics of adaptive deep brain stimulation for Parkinson’s Disease

    Katsuo Kimura, Hideo Mure, Hideki Oshima, Haruhiko Kishima, Nagako Murase, Yoshio Tsuboi, Takashi Tsuboi, Tatsuya Takezaki, Yoshinori Higuchi, Genko Oyama

    2023.11.3 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  5. Local field potential and programming characteristics of adaptive deep brain stimulation for Parkinson’s Disease in Japan

    Katsuo Kimura, Hideo Mure, Hideki Oshima, Haruhiko Kishima, Nagako Murase, Yoshio Tsuboi, Takashi Tsuboi, Tatsuya Takezaki, Yoshinori Higuchi, Yasushi Shimo, Takao Hashimoto, Alexa Singer, Katherine Stromberg, Nathan Morelli, Isabelle Buffin, Kazuhiro Hidaka, Genko Oyama

    XXV Congress of the European Society for Stereotactic and Functional Neurosurgery  2023.9.26 

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    Event date: 2023.9 - 2023.10

    Language:English   Presentation type:Oral presentation (general)  

  6. Characterizing essential tremor and dystonic tremor using 3D accelerometry analysis

    Takashi Tsuboi, Keito Sawada, Sena Hoshino, Moeka Higuchi, Manabu Mutoh, Jun Torii, Daisuke Nakatsubo, Satoshi Maesawa, Masashi Suzuki, Maki Sato, Keita Hiraga, Yuki Satake, Katsunori Yokoi, Makoto Hattori, Ryuta Saito, Masahisa Katsuno

    8th Asian and Oceanian Parkinson’s Disease and Movement Disorders Congress  2023.3.19 

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    Event date: 2023.3

    Language:English   Presentation type:Poster presentation  

  7. Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation

    Tsuboi T, Wong JK, Eisinger RS, Okromelidze L, Burns MR, Ramirez-Zamora A, Almeida L, Wagle Shukla A, Foote KD, Okun MS, Grewal SS, Middlebrooks EH

    International Congress of Parkinson’s Disease and Movement Disorders  2021.9.18 

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    Event date: 2021.9

    Language:English   Presentation type:Poster presentation  

  8. The Subthalamic Fasciculus and Connectivity Profiling of Stimulation-induced Dyskinesia following Pallidal DBS in Parkinson’s Disease.

    Tsuboi T, Elkouzi A, Deeb W, Ramirez-Zamora A, Almeida L, Zeilman P, Eisinger R, Foote K, Okromelidze L, Grewal S, Okun M, Middlebrooks E

    The Movement Disorders Society Virtual Congress 2020  2020.9.13 

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    Event date: 2020.9

    Language:English   Presentation type:Poster presentation  

  9. Importance of the initial response to GPi deep brain stimulation in isolated dystonia: A nine year quality of life study.

    Tsuboi T, Jabarkheel Z, Foote K, Okun S, Wagle Shukla A

    XXIV World Congress on Parkinson's Disease and Related Disorders (IAPRD), Montreal, Canada  2019.6.19 

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    Event date: 2019.6

    Language:English   Presentation type:Poster presentation  

  10. Outcomes with VIM deep brain stimulation in dystonic tremor versus essential tremor.

    Tsuboi T, Jabarkheel Z, Foote K, Okun S, Wagle Shukla A

    2019 American Academy of Neurology Annual Meeting, Philadelphia, USA  2019.5.9 

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    Event date: 2019.5

    Language:English   Presentation type:Poster presentation  

  11. How is DBS now and ten years later? Invited

    Tsuboi T

    The 18th International Parkinson Disease Symposium, Takamatsu, Japan  2019.3.16 

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    Event date: 2019.3

    Language:English   Presentation type:Oral presentation (invited, special)  

  12. Clinical correlates of stuttering in advanced Parkinson’s disease.

    Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Hattori M, Kawabata K, Hara K, Nakatsubo D, Maesawa S, Kajita Y, Wakabayashi T, Katsuno M, Sobue G

    the 23th International Congress of Parkinson's disease and movement disorders, Hong Kong, China  2018.10.7 

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    Event date: 2018.10

    Language:English   Presentation type:Poster presentation  

  13. Longitudinal changes in speech and voice functions after subthalamic nucleus deep brain stimulation in Parkinson’s disease patients.

    Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Kawabata K, Hara K, Nakatsubo D, Maesawa S, Kajita Y, Katsuno M, Sobue G

    the XXIII World Congress of Neurology, Kyoto, Japan.  2017.9.16 

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

  14. Longitudinal changes in speech and voice functions after subthalamic stimulation in Parkinson’s disease patients.

    Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Kawabata K, Hara K, Nakatsubo D, Maesawa S, Kajita Y, Wakabayashi T, Katsuno M, Sobue G

    the 21th International Congress of Parkinson's disease and movement disorders, Vancouver, Canada.  2017.6.5 

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    Event date: 2017.6

    Language:English   Presentation type:Poster presentation  

  15. Longitudinal changes in speech and voice functions after subthalamic stimulation in Parkinson’s disease patients.

    Tsuboi T, Watanabe H, Tanaka Y, Ohdake R, Kawabata K, Hara K, Nakatsubo D, Maesawa S, Kajita Y, Katsuno M, Sobue G

    the 2nd International Taiwanese Congress of Neurology, Taipei, Taiwan  2017.5.19 

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    Event date: 2017.5

    Language:English   Presentation type:Poster presentation  

  16. How to diagnose Parkinsonism. Invited

    Tsuboi T

    The 16th International Parkinson Disease Symposium, Takamatsu, Japan.  2017.2.17 

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    Event date: 2017.2

    Language:English   Presentation type:Oral presentation (invited, special)  

  17. DBS vs Drug therapy in PD patients. Invited

    Tsuboi T

    The 16th International Parkinson Disease Symposium, Takamatsu, Japan.  2017.2.18 

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    Event date: 2017.2

    Language:English   Presentation type:Oral presentation (invited, special)  

  18. 30-year-old man with progressive motor weakness in the right limbs.

    Tsuboi T

    The 16th International Parkinson Disease Symposium, Takamatsu, Japan.  2017.2.18 

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    Event date: 2017.2

    Language:English   Presentation type:Oral presentation (general)  

  19. Longitudinal changes of speech and voice disorders following subthalamic stimulation in Parkinson’s disease patients.

    Takashi Tsuboi, Hirohisa Watanabe, Yasuhiro Tanaka, Reiko Ohdake, Kazuya Kawabata, Kazuhiro Hara, Mizuki Ito, Masaaki Hirayama, Yasushi Fujimoto, Yasukazu Kajita, Masahisa Katsuno, Gen Sobue

    the 20th International Congress of Parkinson's disease and movement disorders, Berlin, Germany.  2016.6.20 

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    Event date: 2016.6

    Language:English   Presentation type:Poster presentation  

  20. Improving therapeutic strategies for Parkinson's disease patients treated with deep brain stimulation, particularly focusing on speech and voice functions.

    Takashi Tsuboi, Hirohisa Watanabe, Yasuhiro Tanaka, Reiko Ohdake, Kazuya Kawabata, Kazuhiro Hara, Mizuki Ito, Masaaki Hirayama, Yasushi Fujimoto, Yasukazu Kajita, Masahisa Katsuno, Gen Sobue

    the Basic Scientists Summer School, Tokyo, Japan  2015.8.7 

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    Event date: 2015.8

    Language:English   Presentation type:Oral presentation (general)  

  21. Distinct phenotypes of speech and voice disorders in Parkinson’s disease after subthalamic nucleus deep brain stimulation.

    Tsuboi T, Tanaka Y, Watanabe H, Sobue G

    2015 American Academy of Neurology Annual Meeting, Washington DC, USA  2015.4.20 

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    Event date: 2015.4

    Language:English   Presentation type:Poster presentation  

  22. Predictors of Suboptimal Response for Deep Brain Stimulation in DYT1 Dystonia: A Multi-center Cohort.

    Tsuboi T

    The 10th Tyler’s Hope Foundation Think Tank, Gainesville, USA  2019.12.7 

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. 集束超音波療法、脳機能画像解析と動作解析を通した振戦性疾患の病態メカニズム解明

    2022.5 - 2024.3

    Takeda Japan Medical Office Funded Research Grant 2022 

    坪井崇

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    Grant type:Competitive

    Grant amount:\2000000

  2. アダプティブ脳深部刺激療法日本レジストリ(aDBS Japan Registry)

    2021.10 - 2024.2

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    Authorship:Coinvestigator(s) 

KAKENHI (Grants-in-Aid for Scientific Research) 10

  1. 集束超音波療法、脳機能画像解析と動作解析を通した振戦性疾患の病態メカニズム解明

    2022.5 - 2024.3

    武田薬品  Takeda Japan Medical Office Funded Research Grant 2022 

    坪井崇

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    Grant type:Competitive

  2. Research for development of connectome-based functional neurosurgery and non-invasive simulation system

    Grant number:22H03184  2022.4 - 2027.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  3. 集束超音波療法と脳機能画像解析を通した振戦性疾患の病態メカニズム解明

    Grant number:22K15727  2022.4 - 2024.3

    日本学術振興会  科学研究費助成事業  若手研究

    坪井 崇

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    パーキンソン病・本態性振戦・ジストニア性振戦それぞれにおいて,1年間に10~20例の組み入れを想定している.研究期間終了までに術前後の評価が終了した症例については,研究計画1(パーキンソン病・本態性振戦・ジストニア性振戦における振戦に関連する脳ネットワークの相互比較),研究計画2(加速度計および表面筋電図における診断マーカーの検討),研究計画3(FUSを施行するパーキンソン病・本態性振戦・ジストニア性振戦におけるQOL変化の解析)の全てについて解析を行い,術前のみの評価が終了した症例については研究計画2の解析を行う予定としている.
    2021年4月から現在までに,合計41例の本態性振戦,ジストニア性振戦,パーキンソン病患者の研究への組み入れ,術前評価を行った.振戦重症度評価 (Fahn-Tolosa-Marin tremor rating scale, TRS)およびQOL評価尺度 (Quality of life in essential tremor questionnaire, QUEST; EuroQol) に加え,脳機能画像 (安静時機能的MRI)・拡散テンソル画像の撮像,加速度計および表面筋電図を用いた評価も行った.
    術前データの中でも特に加速度計データに着目し,本態性振戦およびジストニア性振戦の加速度計評価による特徴抽出を試みるとともに,加速度計の診断マーカーとなる可能性について,学会報告を行った.姿勢時振戦および動作時振戦の周波数は本態性振戦群でジストニア性振戦群よりも有意に大きかった.さらに,姿勢性振戦と運動性振戦の振幅の大きさの非対称性がジストニア性振戦群で有意に大きい結果であり,両疾患の鑑別に有用である可能性が示唆された.現在は論文化を目指し,症例のさらなる蓄積を行っている.
    また,集束超音波療法を施行した患者においては,名古屋大学および協力病院における術後の定期評価を行っている.データが蓄積されれば,術前後での比較が可能となる.術前後の比較により,(1) FUSの振戦および生活の質を改善する臨床効果を明らかにする,(2) 相互比較を通したパーキンソン病・本態性振戦・ジストニア性振戦における振戦に関連する脳ネットワークの共通点・相違点を安静時機能的MRIを用いて明らかにする,ことが期待される.研究は概ね計画通りに推移している.
    以下の通り,本研究から得られたデータのうち,特に加速度計データについてまとめた成果を国内外の学会にて発表した.本態性振戦15例,ジストニア性振戦20例の比較から,姿勢時振戦のFrequency width half magnitudeは本態性振戦群 0.6 ± 0.2,ジストニア性振戦群 1.3 ± 1.3(p=0.004),運動時振戦のTremor stability indexは本態性振戦群 0.0 ± 0.0,ジストニア性振戦群 0.6 ± 1.2(p=0.024)といずれもジストニア性振戦で高く,ジストニア性振戦群で振戦のリズムがより不規則であることが示唆された.今回の検討結果から,加速度計を用いた解析によって,両疾患の振戦の相違点を抽出可能であることが分かった.特に,Frequency width half magnitudeとTremor stability indexはいずれも振戦のリズムの規則性の程度を表すパラメータであるが,我々の対象群においてもETとDTの振戦のリズムの規則性の相違を検出できるパラメータであることが示唆された.今後は,既存のパラメータの組み合わせや新規パラメータの開発を通して,ETやDTの客観的な診断や重症度評価のマーカーとして確立すること,英語論文発表を目指している.
    また,術後の臨床データ,MRIデータなどの取得も順調に経過しており,データが蓄積されれば,これらを対象とした解析も可能となる見込みである.
    本態性振戦およびジストニア性振戦の集束超音波療法の術前の加速度計データを用いた検討結果については,さらに症例数を蓄積した上で,2023年度中の英語論文化を目指している.
    また,名古屋大学および協力病院において,術後1年の臨床データおよびMRIデータの収集を予定通り進めていく.これにより,(1) FUSの振戦および生活の質に対する臨床効果,(2) パーキンソン病・本態性振戦・ジストニア性振戦における振戦に関連する脳ネットワークの相違を明らかにすることを目指す.
    なお,本年度のMRI撮影件数の実績および次年度のMRI撮影予定件数の見込みから,次年度使用額が生じた.

  4. 遺伝性ジストニアに対する脳深部刺激療法(Deep Brain Stimulation)の治療効果に関わる臨床的および遺伝的因子の解明

    2019.4 - 2020.3

    上原記念生命科学財団 

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    Authorship:Coinvestigator(s) 

  5. リリー・サイエンティフィック・フェローシップ・プログラム

    2018.4 - 2019.3

    日本イーライリリー株式会社 

  6. Pathological elucidation of tremor by various modality and modification by Focal Ultrasounds and Deep Brain Stimulation

    Grant number:17K10891  2017.4 - 2020.3

    Nakatsubo Daisuke

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    Authorship:Coinvestigator(s) 

    MRgFUS (MR-guided focused ultrasound) has become possible in Japan as a non-invasive coagulation therapy for the treatment of involuntary movements such as essential tremor. In this study, the improvement rate of the upper limbs was about 65% one year after treatment, and no serious complications were observed. In addition, network analysis by resting fMRI revealed that the more severe the tremor, the lower the connectivity of the network, and the higher brain function mainly in the frontal lobe is also impaired.

  7. 認知症を伴うパーキンソン病の大脳皮質における前初期遺伝子発現異常の解析

    2016.12 - 2018.3

    グラクソスミスクラインジャパン 

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    Authorship:Principal investigator 

  8. Pathophysiology of speech and voice disorders in Parkinson's disease patients treated with deep brain stimulation

    Grant number:16K19507  2016.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Takashi Tsuboi

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    We aimed to reveal the pathophysiology of speech and voice disorders in Parkinson’s disease (PD) patients treated with deep brain stimulation (DBS) and establish the treatment strategies for them. We found that Approximately 90% of PD patients had one or more types of speech and voice disorders (hypokinetic dysarthria, breathy voice, and stuttering) before surgery, which stemmed from PD itself, that Strained voice and spastic dysarthria were the most common DBS-induced speech and voice disorders, and that stuttering and breathy voice can be worsened by STN-DBS in a minority of patients. Additionally, male gender, worse cognitive function especially visuospatial/executive function and memory, worse motor function, and higher dose of anti-parkinsonian drugs are the possible risk factors for stuttering. Further studies are warranted to establish objective evaluation methods of speech and voice disorders and effective treatment strategies.

  9. 多系統萎縮症の正確な病期診断法の開発

    Grant number:16K09714  2016.4 - 2017.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    伊藤 瑞規, 勝野 雅央, 坪井 崇, 小池 春樹, 原 一洋, 熱田 直樹

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    Authorship:Coinvestigator(s) 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    多系統萎縮症(MSA)は、50~60代の働き盛りの年代に好発する神経難病であり、現在のところ早期診断や正確な病期診断が難しい疾患の一つである。50~60代は初老期にあたり、認知症を発症したり、また健常者であっても脳の様々な変化を起こし得ると思われる。多系統萎縮症の早期診断や正確な病期診断を行うためには、これら健常者に起こり得ると思われる脳の萎縮や解剖学的・機能的神経回路の変化を確認することは極めて重要であると考えられる。
    そこで、本年度は名古屋大学 脳とこころの研究センターで構築中の正常健常者の大規模な認知機能と頭部MRIのコホートを用いて、年齢とともに小脳の萎縮、小脳の解剖学的、機能的神経回路がどのように変化しているかを検討した。
    研究に同意の得られた連続445例のうち、うつ症状がなく、各種認知機能検査で異常を認めず、頭部MRI画像で脳梗塞・脳出血や脳腫瘍などを認めない295例の解析を行った。
    Voxel-based morphometry(VBM)、Tract-based spatial statistics(TBSS)および安静時脳機能MRIを大脳と小脳で評価した。VBMでは、大脳において頭頂葉、側頭葉、一部の前頭葉に萎縮を認め、小脳では小脳歯状核、虫部頭側に萎縮を認めた。TBSSでは、大脳で側脳室周囲の異常を認めたが、小脳では異常を認めなかった。安静時機能MRIでは、大脳でExecutive control networkやDefault mode networkなどの様々な機能的回路の異常を認めたが、小脳では異常を認めなかった。
    健常者において、大脳は様々な変化を認めていたが、小脳においては萎縮を認めるものの、解剖学的・機能的神経回路の異常を認めず、小脳の異常をきたしやすいMSAと比較するのに適していると考えられた。

  10. 脳深部刺激療法後のパーキンソン病患者における発話障害の病態解明と治療法の開発

    2016.4 - 2017.3

    ノバルティスファーマ 

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    Authorship:Principal investigator 

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Teaching Experience (On-campus) 13

  1. 脳神経内科

    2023

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    医学部5,6年生に対する講義,実習

  2. 医学

    2023

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    医学部生に対するオンラインPBL

  3. 脳神経内科

    2023

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    医学部4年生に対する臨床講義

  4. 医学

    2023

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    看護師特定行為研修

  5. 脳神経内科

    2022

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    医学部5,6年生に対する講義,実習

  6. 脳神経内科

    2022

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    岐阜大学とのジョイントプログラム.反転学習

  7. 医学

    2022

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    文系学生に対する医学の講義

  8. 脳神経内科

    2022

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    医学部4年生に対する臨床講義

  9. 医学

    2022

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    看護師特定行為研修

  10. 看護師特定行為研修

    2021

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    看護師特定行為研修

  11. 脳神経内科

    2021

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    医学部5,6年生に対する講義,実習

  12. 脳神経内科

    2021

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    岐阜大学とのジョイントプログラム.反転学習

  13. 脳神経内科

    2021

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    医学部4年生に対する臨床講義

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Teaching Experience (Off-campus) 2

  1. Neurology

    2020.4 Nagoya University)

  2. Medicine

    2020.4 Nagoya University)