記述言語：英語   出版者・発行元：Biomacromolecules  

We prepared biocompatible elastic fibers with high porosity and high tensile strength from poly[(R)-3-hydroxybutyrate-co-4-hydroxybutyrate], which is a microbial polyester that can be produced from renewable carbon resources by isothermal crystallization. It was possible to control the pore size by adjusting the isothermal crystallization time. Most of the pores were approximately less than 10 μm in diameter, did not penetrate, and were distributed discontinuously throughout the fibers. The elasticity of the fibers was apparently attributable to the generation of tie molecules with planar zigzag conformations between lamellar crystals and to the deformation of the pores. The ligature area occupied by the porous fibers in surgical knots was reduced by 75% compared with that of nonporous fibers. This is expected to make the ligature more difficult to untie and reduce the feeling of foreign matter. X-ray tomography revealed that the porous fibers had a relatively small fiber diameter owing to the collapse of the porous area. The rate of enzymatic degradation of the porous fibers was more than four times that of nonporous fibers. These results suggest that this elastic porous fiber will have many applications, including in the medical and marine material fields.

DOI： 10.1021/acs.biomac.4c01144

Web of Science

Scopus

PubMed

記述言語：英語   出版者・発行元：Diagnostics  

Malunion of thumb and finger fractures causes problems in the cosmetic and functional aspects of the hand. Malunion of phalangeal fractures usually manifests as a combination of rotational deformities in the coronal, sagittal, and transverse planes, and corrective osteotomy is performed on the planes that cause these problems. Quantification of the deformity is essential for precise osteotomy and is difficult to perform in the transverse plane, even with radiography or computed tomography. Thus, we developed a technique called linkage simulation for the quantitative measurement of rotational deformities for surgical planning. In this procedure, finger extension and flexion can be simulated based on the predicted rotational axis of the joint, which is useful for determining the appropriate correction. Furthermore, by performing a reduction simulation in the software, it is possible to simulate the surgery and predict the postoperative results. This paper reports the details of this technique.

DOI： 10.3390/diagnostics14161818

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PubMed

担当区分：筆頭著者   記述言語：英語   出版者・発行元：Scientific Reports  

To address the growing demand for more elastic sutures free from unwanted knot loosening, we fabricated an absorbable monofilament suture from poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and subjected it to physical property characterization and performance evaluation (in vitro and in vivo degradability tests and a porcine abdominal wall suture test). As this flexible, highly stretchable, and difficult-to-untie suture exhibited additional advantages of small knot size and medium to long-term bioabsorbability, it was concluded to be a safe alternative to existing monofilament sutures, with far-reaching potential applications.

DOI： 10.1038/s41598-023-30292-w

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PubMed

記述言語：日本語   出版者・発行元：日本肘関節学会  

神経周膜腫は稀な神経原性腫瘍である．尺骨神経に発生し，肘部管症候群と鑑別を要した症例を経験したので報告する．症例は，17歳男性．2年前から握力低下，環指小指の痺れを自覚，徐々に手の変形も進行し，前医を受診した．身体所見，神経伝導速度検査から肘部管症候群と診断し，神経剥離，皮下前方移行術を施行するも神経所見の回復が乏しかった．術後2年経過時，上腕骨内側上顆近位レベルで尺骨神経に索状物を触れ，神経原性腫瘍を疑い当院に紹介された．<BR>　腫大した尺骨神経を7cm切除，腓腹神経でcable graftを作成し，神経移植した．病理所見は、EMA陽性，S-100陰性の神経周膜細胞の増殖を認め，神経内神経周膜腫と診断した．<BR>　筋力は徐々に回復し，術後6年経過時点で，骨間筋の萎縮は残存するも，鷲手変形は認めず，小指は感覚鈍麻が残存するも感覚障害も回復傾向を示した．この論文は第35回日本肘関節学会で発表した．

DOI： 10.24810/jelbow.30.2_402

CiNii Research

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1177/17531934211059300

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PubMed

総ページ数：7   担当ページ：S176-182   記述言語：日本語 著書種別：教科書・概説・概論

開催年月日： 2023年12月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（指名）  

開催地：名古屋   国名：日本国  

開催年月日： 2023年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：つくば   国名：日本国  

開催年月日： 2023年10月

記述言語：英語   会議種別：ポスター発表  

開催地：Toronto   国名：カナダ  

開催年月日： 2023年5月 - 2023年6月

記述言語：英語   会議種別：ポスター発表  

開催地：Singapore   国名：シンガポール共和国