Language：English   Publisher：Biomacromolecules  

We prepared biocompatible elastic fibers with high porosity and high tensile strength from poly[(R)-3-hydroxybutyrate-co-4-hydroxybutyrate], which is a microbial polyester that can be produced from renewable carbon resources by isothermal crystallization. It was possible to control the pore size by adjusting the isothermal crystallization time. Most of the pores were approximately less than 10 μm in diameter, did not penetrate, and were distributed discontinuously throughout the fibers. The elasticity of the fibers was apparently attributable to the generation of tie molecules with planar zigzag conformations between lamellar crystals and to the deformation of the pores. The ligature area occupied by the porous fibers in surgical knots was reduced by 75% compared with that of nonporous fibers. This is expected to make the ligature more difficult to untie and reduce the feeling of foreign matter. X-ray tomography revealed that the porous fibers had a relatively small fiber diameter owing to the collapse of the porous area. The rate of enzymatic degradation of the porous fibers was more than four times that of nonporous fibers. These results suggest that this elastic porous fiber will have many applications, including in the medical and marine material fields.

DOI： 10.1021/acs.biomac.4c01144

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Scopus

PubMed

Language：English   Publisher：Diagnostics  

Malunion of thumb and finger fractures causes problems in the cosmetic and functional aspects of the hand. Malunion of phalangeal fractures usually manifests as a combination of rotational deformities in the coronal, sagittal, and transverse planes, and corrective osteotomy is performed on the planes that cause these problems. Quantification of the deformity is essential for precise osteotomy and is difficult to perform in the transverse plane, even with radiography or computed tomography. Thus, we developed a technique called linkage simulation for the quantitative measurement of rotational deformities for surgical planning. In this procedure, finger extension and flexion can be simulated based on the predicted rotational axis of the joint, which is useful for determining the appropriate correction. Furthermore, by performing a reduction simulation in the software, it is possible to simulate the surgery and predict the postoperative results. This paper reports the details of this technique.

DOI： 10.3390/diagnostics14161818

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PubMed

Authorship：Lead author   Language：English   Publisher：Scientific Reports  

To address the growing demand for more elastic sutures free from unwanted knot loosening, we fabricated an absorbable monofilament suture from poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and subjected it to physical property characterization and performance evaluation (in vitro and in vivo degradability tests and a porcine abdominal wall suture test). As this flexible, highly stretchable, and difficult-to-untie suture exhibited additional advantages of small knot size and medium to long-term bioabsorbability, it was concluded to be a safe alternative to existing monofilament sutures, with far-reaching potential applications.

DOI： 10.1038/s41598-023-30292-w

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PubMed

Language：Japanese   Publisher：Japan Elbow Society  

DOI： 10.24810/jelbow.30.2_402

CiNii Research

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1177/17531934211059300

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PubMed

Total pages：7   Responsible for pages：S176-182   Language：Japanese Book type：Textbook, survey, introduction

Event date： 2023.12

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：名古屋   Country：Japan  

Event date： 2023.10

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：つくば   Country：Japan  

Event date： 2023.10

Language：English   Presentation type：Poster presentation  

Venue：Toronto   Country：Canada  

Event date： 2023.5 - 2023.6

Language：English   Presentation type：Poster presentation  

Venue：Singapore   Country：Singapore