2022/05/26 更新

写真a

フルカワ ノゾミ
古川 希
FURUKAWA Nozomi
所属
大学院医学系研究科 総合保健学専攻 オミックス医療科学 助教
大学院担当
大学院医学系研究科
学部担当
医学部(保健学科)
職名
助教

学位 1

  1. 博士(医学) ( 2021年3月   群馬大学 ) 

研究キーワード 1

  1. ライフサイエンス、循環器内科学、生理学、自律神経、腸内細菌学、代謝・内分泌学

経歴 2

  1. 名古屋大学   総合保健学専攻 オミックス医療科学 病態情報科学講座   助教

    2020年10月 - 現在

  2. 群馬大学   循環器内科学   日本学術振興会 特別研究員(DC1)

    2018年4月 - 2020年9月

受賞 2

  1. American Heart Association (AHA) 2018 Scientific Sessions Basic Cardiovascular Sciences Abstract Travel Awa

    2018年11月  

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    受賞区分:国際学会・会議・シンポジウム等の賞 

  2. American Heart Association (AHA) 2016 Scientific Sessions Basic Cardiovascular Sciences Abstract Travel Award

    2016年11月  

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    受賞区分:国際学会・会議・シンポジウム等の賞 

 

論文 7

  1. Pharmacological inhibition of the lipid phosphatase PTEN ameliorates heart damage and adipose tissue inflammation in stressed rats with metabolic syndrome

    Ashikawa Sao, Komatsu Yuki, Kawai Yumeno, Aoyama Kiyoshi, Nakano Shiho, Cui Xixi, Hayakawa Misaki, Sakabe Nanako, Furukawa Nozomi, Ikeda Katsuhide, Murohara Toyoaki, Nagata Kohzo

    PHYSIOLOGICAL REPORTS   10 巻 ( 1 ) 頁: e15165   2022年1月

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    記述言語:日本語   出版者・発行元:Physiological Reports  

    Phosphatidylinositol 3-kinase (PI3K) signaling promotes the differentiation and proliferation of regulatory B (Breg) cells, and the lipid phosphatase phosphatase and tensin homolog deleted on chromosome 10 (PTEN) antagonizes the PI3K–Akt signaling pathway. We previously demonstrated that cardiac Akt activity is increased and that restraint stress exacerbates hypertension and both heart and adipose tissue (AT) inflammation in DS/obese rats, an animal model of metabolic syndrome (MetS). We here examined the effects of restraint stress and pharmacological inhibition of PTEN on heart and AT pathology in such rats. Nine-week-old animals were treated with the PTEN inhibitor bisperoxovanadium-pic [bpV(pic)] or vehicle in the absence or presence of restraint stress for 4 weeks. BpV(pic) treatment had no effect on body weight or fat mass but attenuated hypertension in DS/obese rats subjected to restraint stress. BpV(pic) ameliorated left ventricular (LV) inflammation, fibrosis, and diastolic dysfunction as well as AT inflammation in the stressed rats. Restraint stress reduced myocardial capillary density, and this effect was prevented by bpV(pic). In addition, bpV(pic) increased the proportions of Breg and B-1 cells as well as reduced those of CD8+ T and B-2 cells in AT of stressed rats. Our results indicate that inhibition of PTEN by bpV(pic) alleviated heart and AT inflammation in stressed rats with MetS. These positive effects of bpV(pic) are likely due, at least in part, to a reduction in blood pressure, an increase in myocardial capillary formation, and an altered distribution of immune cells in fat tissue that result from the activation of PI3K–Akt signaling.

    DOI: 10.14814/phy2.15165

    Web of Science

    Scopus

    PubMed

  2. Characterizing the Effect of Processing Technique and Solution Type on Cytomorphology Using Liquid-Based Cytology

    Ikeda Katsuhide, Oboshi Wataru, Hashimoto Yusuke, Komene Tetsuya, Yamaguchi Yoshitaka, Sato Shouichi, Maruyama Sayumi, Furukawa Nozomi, Sakabe Nanako, Nagata Kohzo

    ACTA CYTOLOGICA   66 巻 ( 1 ) 頁: 55 - 60   2021年10月

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    記述言語:日本語   出版者・発行元:Acta Cytologica  

    Introduction: Liquid-based cytology (LBC) is increasingly used for nongynecologic applications. However, the cytological preparation of LBC specimens is influenced by the processing technique and the preservative used. In this study, the influence of the processing techniques and preservatives on cell morphology was examined mathematically and statistically. Methods: Cytological specimens were prepared using the ThinPrep (TP), SurePath (SP), and AutoSmear methods, with 5 different preservative solutions. The cytoplasmic and nuclear areas of Papanicolaou-stained specimens were measured for all samples. Results: The cytoplasmic and nuclear areas were smaller in cells prepared using the 2 LBC methods, compared to that prepared using the AutoSmear method, irrespective of the preservative used. The cytoplasmic and nuclear areas of cells prepared using the SP method were smaller than those of cells prepared using the TP method, irrespective of the preservative used. There were fewer differences among the cytoplasmic areas of cells prepared with different preservative solutions using the TP method; however, the cytoplasmic areas of cells prepared using the SP method changed with the preservative solution used. Conclusions: The most significant difference affecting the cytoplasmic and nuclear areas was the processing technique. The TP method increased the cytoplasmic and nuclear areas, while the methanol-based PreservCyt solution enabled the highest enlargement of the cell. LBC is a superior preparation technique for standardization of the specimens. Our results offer a better understanding of methods suitable for specimen preparation for developing precision AI-based diagnosis in cytology.

    DOI: 10.1159/000519335

    Web of Science

    Scopus

    PubMed

  3. Surgical ablation of whitened interscapular brown fat ameliorates cardiac pathology in salt-loaded metabolic syndrome rats

    Komatsu Yuki, Aoyama Kiyoshi, Yoneda Mamoru, Ito Shogo, Sano Yusuke, Kawai Yumeno, Cui Xixi, Yamada Yuichiro, Furukawa Nozomi, Ikeda Katsuhide, Nagata Kohzo

    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES   1492 巻 ( 1 ) 頁: 11 - 26   2021年5月

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    記述言語:日本語   出版者・発行元:Annals of the New York Academy of Sciences  

    Brown adipose tissue (BAT) is an endocrine organ that contributes to thermogenesis and energy consumption. We investigated the effects of salt loading and surgical removal of whitened interscapular BAT (iBAT) on cardiac and adipose tissue pathology in DahlS.Z-Leprfa/Leprfa (DS/obese) rats, an animal model of metabolic syndrome (MetS). DS/obese rats were subjected to surgical removal of iBAT or sham surgery at 8 weeks of age and were provided with drinking water containing or not containing 0.3% NaCl for 4 weeks beginning at 9 weeks of age. Removal of iBAT suppressed the salt-induced exacerbation of left ventricular inflammation, fibrosis, and diastolic dysfunction, but not that of hypertension development, in DS/obese rats. Salt loading attenuated adipocyte hypertrophy but enhanced inflammation in both visceral white adipose tissue (WAT) and iBAT. Although iBAT removal did not affect visceral WAT pathology in salt-loaded DS/obese rats, it attenuated the elevation of circulating interleukin-6 levels in these animals. Downregulation of uncoupling protein-1 expression in iBAT of DS/obese rats was not affected by salt loading. Our results suggest that the conversion of iBAT to WAT-like tissue contributes to a salt-induced elevation of circulating proinflammatory cytokine levels that leads to exacerbation of cardiac pathology in this model of MetS.

    DOI: 10.1111/nyas.14546

    Web of Science

    Scopus

    PubMed

  4. The prebiotic fiber inulin ameliorates cardiac, adipose tissue, and hepatic pathology, but exacerbates hypertriglyceridemia in rats with metabolic syndrome

    Komatsu Yuki, Aoyama Kiyoshi, Yoneda Mamoru, Ashikawa Sao, Nakano Shiho, Kawai Yumeno, Cui Xixi, Furukawa Nozomi, Ikeda Katsuhide, Nagata Kohzo

    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY   320 巻 ( 1 ) 頁: H281 - H295   2021年1月

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    出版者・発行元:American Journal of Physiology - Heart and Circulatory Physiology  

    DOI: 10.1152/ajpheart.00657.2020

    Web of Science

    Scopus

    PubMed

  5. DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism.

    Furukawa N, Koitabashi N, Matsui H, Sunaga H, Umbarawan Y, Syamsunarno MRAA, Yamaguchi A, Obokata M, Hanaoka H, Yokoyama T, Kurabayashi M

    Heart and vessels   36 巻 ( 1 ) 頁: 136 - 146   2021年1月

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  6. Periostin-expressing cell-specific transforming growth factor-β inhibition in pulmonary artery prevents pulmonary arterial hypertension.

    Seki M, Furukawa N, Koitabashi N, Obokata M, Conway SJ, Arakawa H, Kurabayashi M

    PloS one   14 巻 ( 8 ) 頁: e0220795   2019年

  7. Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise.

    Iso T, Sunaga H, Matsui H, Kasama S, Oshima N, Haruyama H, Furukawa N, Nakajima K, Machida T, Murakami M, Yokoyama T, Kurabayashi M

    Clinical biochemistry   50 巻 ( 16-17 ) 頁: 896 - 902   2017年11月

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科研費 2

  1. FGF21のミトコンドリアオートファジーを介した心臓の栄養・代謝調節機構の解明

    研究課題/研究課題番号:21K17639  2021年4月 - 2023年3月

    若手研究

    古川 希

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    担当区分:研究代表者 

    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

  2. 心臓のエネルギー代謝における心臓線維芽細胞と心筋細胞の相互連関

    研究課題/研究課題番号:18J23428  2018年4月 - 2021年3月

    科学研究費助成事業  特別研究員奨励費

    古川 希

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    担当区分:その他 

    ①線維芽細胞特異的FGF21欠損マウス[FB-FGF21KOマウス]:前年度よりサンプル数を重ねて、コンダクタンスカテーテルで詳細に心機能検討したところ、コントロール圧負荷群と比較し収縮期末圧容積関係や弛緩能[Tau]がFB-FGF21KOマウス群では更に増悪していた。心臓エネルギー代謝の定量の検討では、糖取り込みはコントロールの圧負荷群で有意に増加していたが、FB-FGF21KOマウスの圧負荷群と比較し更に増加傾向であることが分かった。脂肪酸取り込みはコントロール群との差は見られなかった。その他、マッソン染色による線維化定量の検討ではコントロールの圧負荷群と比較しFB-FGF21KOマウスの圧負荷群で更に増悪していることが分かった。これまでの研究成果はアメリカ心臓学会基礎研究会(BCVS)2020に採択された。②心筋細胞特異的FGF21欠損マウス[MCM-FGF21KOマウス]:前年度ではFGF21floxマウスとMCM-FGF21の圧負荷無処置・処置群の4群で比較検討したが、FGF21mflox群も加え全6群のマウスの心臓におけるRNAサンプルにて検討を行った。その結果、心ストレスや線維化マーカーのmRNA発現がMCM-FGF21KOマウス群では増悪することが分かった。③全身FGF21欠損マウス[FGF21KOマウス]:これまでのKOマウスと同様、圧負荷後に著明な収縮能の低下、拡張末期径の増悪がみられた。圧負荷1週及び3-4週後でタイムコース実験を行い急性期/慢性期のFGF21の応答を検討したところ、特に圧負荷1週で心機能が著明に低下することが明らかとなった。以上より、FGF21は病的心ストレスに対して多臓器だけでなく心臓自体からも産生され、線維芽細胞によるパラクライン作用、心筋細胞自体からのオートクライン作用によっても心臓エネルギー代謝を調節する可能性が示唆された。
    令和2年度が最終年度であるため、記入しない。
    令和2年度が最終年度であるため、記入しない。