Updated on 2022/05/26


Graduate School of Medicine Assistant Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Assistant Professor

Degree 1

  1. 博士(医学) ( 2021.3   群馬大学 ) 

Research Interests 1

  1. ライフサイエンス、循環器内科学、生理学、自律神経、腸内細菌学、代謝・内分泌学

Research History 2

  1. Nagoya University   Assistant Professor


  2. Gunma University

    2018.4 - 2020.9

Awards 2

  1. American Heart Association (AHA) 2018 Scientific Sessions Basic Cardiovascular Sciences Abstract Travel Awa


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    Award type:Award from international society, conference, symposium, etc. 

  2. American Heart Association (AHA) 2016 Scientific Sessions Basic Cardiovascular Sciences Abstract Travel Award


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    Award type:Award from international society, conference, symposium, etc. 


Papers 7

  1. Pharmacological inhibition of the lipid phosphatase PTEN ameliorates heart damage and adipose tissue inflammation in stressed rats with metabolic syndrome

    Ashikawa Sao, Komatsu Yuki, Kawai Yumeno, Aoyama Kiyoshi, Nakano Shiho, Cui Xixi, Hayakawa Misaki, Sakabe Nanako, Furukawa Nozomi, Ikeda Katsuhide, Murohara Toyoaki, Nagata Kohzo

    PHYSIOLOGICAL REPORTS   Vol. 10 ( 1 ) page: e15165   2022.1

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    Language:Japanese   Publisher:Physiological Reports  

    Phosphatidylinositol 3-kinase (PI3K) signaling promotes the differentiation and proliferation of regulatory B (Breg) cells, and the lipid phosphatase phosphatase and tensin homolog deleted on chromosome 10 (PTEN) antagonizes the PI3K–Akt signaling pathway. We previously demonstrated that cardiac Akt activity is increased and that restraint stress exacerbates hypertension and both heart and adipose tissue (AT) inflammation in DS/obese rats, an animal model of metabolic syndrome (MetS). We here examined the effects of restraint stress and pharmacological inhibition of PTEN on heart and AT pathology in such rats. Nine-week-old animals were treated with the PTEN inhibitor bisperoxovanadium-pic [bpV(pic)] or vehicle in the absence or presence of restraint stress for 4 weeks. BpV(pic) treatment had no effect on body weight or fat mass but attenuated hypertension in DS/obese rats subjected to restraint stress. BpV(pic) ameliorated left ventricular (LV) inflammation, fibrosis, and diastolic dysfunction as well as AT inflammation in the stressed rats. Restraint stress reduced myocardial capillary density, and this effect was prevented by bpV(pic). In addition, bpV(pic) increased the proportions of Breg and B-1 cells as well as reduced those of CD8+ T and B-2 cells in AT of stressed rats. Our results indicate that inhibition of PTEN by bpV(pic) alleviated heart and AT inflammation in stressed rats with MetS. These positive effects of bpV(pic) are likely due, at least in part, to a reduction in blood pressure, an increase in myocardial capillary formation, and an altered distribution of immune cells in fat tissue that result from the activation of PI3K–Akt signaling.

    DOI: 10.14814/phy2.15165

    Web of Science



  2. Characterizing the Effect of Processing Technique and Solution Type on Cytomorphology Using Liquid-Based Cytology

    Ikeda Katsuhide, Oboshi Wataru, Hashimoto Yusuke, Komene Tetsuya, Yamaguchi Yoshitaka, Sato Shouichi, Maruyama Sayumi, Furukawa Nozomi, Sakabe Nanako, Nagata Kohzo

    ACTA CYTOLOGICA   Vol. 66 ( 1 ) page: 55 - 60   2021.10

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    Language:Japanese   Publisher:Acta Cytologica  

    Introduction: Liquid-based cytology (LBC) is increasingly used for nongynecologic applications. However, the cytological preparation of LBC specimens is influenced by the processing technique and the preservative used. In this study, the influence of the processing techniques and preservatives on cell morphology was examined mathematically and statistically. Methods: Cytological specimens were prepared using the ThinPrep (TP), SurePath (SP), and AutoSmear methods, with 5 different preservative solutions. The cytoplasmic and nuclear areas of Papanicolaou-stained specimens were measured for all samples. Results: The cytoplasmic and nuclear areas were smaller in cells prepared using the 2 LBC methods, compared to that prepared using the AutoSmear method, irrespective of the preservative used. The cytoplasmic and nuclear areas of cells prepared using the SP method were smaller than those of cells prepared using the TP method, irrespective of the preservative used. There were fewer differences among the cytoplasmic areas of cells prepared with different preservative solutions using the TP method; however, the cytoplasmic areas of cells prepared using the SP method changed with the preservative solution used. Conclusions: The most significant difference affecting the cytoplasmic and nuclear areas was the processing technique. The TP method increased the cytoplasmic and nuclear areas, while the methanol-based PreservCyt solution enabled the highest enlargement of the cell. LBC is a superior preparation technique for standardization of the specimens. Our results offer a better understanding of methods suitable for specimen preparation for developing precision AI-based diagnosis in cytology.

    DOI: 10.1159/000519335

    Web of Science



  3. Surgical ablation of whitened interscapular brown fat ameliorates cardiac pathology in salt-loaded metabolic syndrome rats

    Komatsu Yuki, Aoyama Kiyoshi, Yoneda Mamoru, Ito Shogo, Sano Yusuke, Kawai Yumeno, Cui Xixi, Yamada Yuichiro, Furukawa Nozomi, Ikeda Katsuhide, Nagata Kohzo

    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES   Vol. 1492 ( 1 ) page: 11 - 26   2021.5

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    Language:Japanese   Publisher:Annals of the New York Academy of Sciences  

    Brown adipose tissue (BAT) is an endocrine organ that contributes to thermogenesis and energy consumption. We investigated the effects of salt loading and surgical removal of whitened interscapular BAT (iBAT) on cardiac and adipose tissue pathology in DahlS.Z-Leprfa/Leprfa (DS/obese) rats, an animal model of metabolic syndrome (MetS). DS/obese rats were subjected to surgical removal of iBAT or sham surgery at 8 weeks of age and were provided with drinking water containing or not containing 0.3% NaCl for 4 weeks beginning at 9 weeks of age. Removal of iBAT suppressed the salt-induced exacerbation of left ventricular inflammation, fibrosis, and diastolic dysfunction, but not that of hypertension development, in DS/obese rats. Salt loading attenuated adipocyte hypertrophy but enhanced inflammation in both visceral white adipose tissue (WAT) and iBAT. Although iBAT removal did not affect visceral WAT pathology in salt-loaded DS/obese rats, it attenuated the elevation of circulating interleukin-6 levels in these animals. Downregulation of uncoupling protein-1 expression in iBAT of DS/obese rats was not affected by salt loading. Our results suggest that the conversion of iBAT to WAT-like tissue contributes to a salt-induced elevation of circulating proinflammatory cytokine levels that leads to exacerbation of cardiac pathology in this model of MetS.

    DOI: 10.1111/nyas.14546

    Web of Science



  4. DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism.

    Furukawa N, Koitabashi N, Matsui H, Sunaga H, Umbarawan Y, Syamsunarno MRAA, Yamaguchi A, Obokata M, Hanaoka H, Yokoyama T, Kurabayashi M

    Heart and vessels   Vol. 36 ( 1 ) page: 136 - 146   2021.1

  5. The prebiotic fiber inulin ameliorates cardiac, adipose tissue, and hepatic pathology, but exacerbates hypertriglyceridemia in rats with metabolic syndrome

    Komatsu Yuki, Aoyama Kiyoshi, Yoneda Mamoru, Ashikawa Sao, Nakano Shiho, Kawai Yumeno, Cui Xixi, Furukawa Nozomi, Ikeda Katsuhide, Nagata Kohzo


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    Publisher:American Journal of Physiology - Heart and Circulatory Physiology  

    DOI: 10.1152/ajpheart.00657.2020

    Web of Science



  6. Periostin-expressing cell-specific transforming growth factor-β inhibition in pulmonary artery prevents pulmonary arterial hypertension.

    Seki M, Furukawa N, Koitabashi N, Obokata M, Conway SJ, Arakawa H, Kurabayashi M

    PloS one   Vol. 14 ( 8 ) page: e0220795   2019

  7. Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise.

    Iso T, Sunaga H, Matsui H, Kasama S, Oshima N, Haruyama H, Furukawa N, Nakajima K, Machida T, Murakami M, Yokoyama T, Kurabayashi M

    Clinical biochemistry   Vol. 50 ( 16-17 ) page: 896 - 902   2017.11

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KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. FGF21のミトコンドリアオートファジーを介した心臓の栄養・代謝調節機構の解明

    Grant number:21K17639  2021.4 - 2023.3


    古川 希

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

  2. 心臓のエネルギー代謝における心臓線維芽細胞と心筋細胞の相互連関

    Grant number:18J23428  2018.4 - 2021.3

    科学研究費助成事業  特別研究員奨励費

    古川 希

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