Updated on 2024/10/21

写真a

 
MOMOHARA Mariko
 
Organization
Nagoya University Hospital Dermatology Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor

Research History 5

  1. 名古屋大学医学部附属病院   皮膚科   助教

    2023.1

  2. ペンシルバニア大学   皮膚科   ポスドク

    2021.1 - 2022.3

  3. 名古屋大学医学部附属病院   皮膚科   助教

    2020.6 - 2020.12

  4. 稲沢市民病院   皮膚科   医員

    2014.9 - 2015.3

  5. 名古屋大学附属病院

    2012.4 - 2014.3

To the head of Research History.▲

Education 1

  1. Nagoya University   School of Medicine   Department of Medicine

    2015.4 - 2018.9

To the head of Education.▲

Professional Memberships 3

  1. 日本リウマチ学会

  2. 日本研究皮膚科学会

  3. 日本皮膚科学会

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Committee Memberships 1

  1. 日本皮膚研究学会   評議員会  

    2022.4   

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Awards 6

  1. 高木賞研究奨励賞

    2024.3   公益財団法人 マルホ・高木皮膚科学振興財団  

  2. 医学系研究科医学奨励賞

    2023.12   名古屋大学医学研究科  

  3. Best Poster Award

    2023.5   5th International conference on cutaneous lupus erythematosus  

  4. ISID2023 Travel Grant

    2023.5   International Society for Investigative Dermatology 2023  

  5. 留学支援制度助成

    2020.1   日本皮膚科学会  

  6. ポストドクトラルフェローシップ

    2019.11   上原記念生命科学財団  

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To the head of Awards.▲
 

Papers 53

  1. Strong correlation between cancer progression and anti-transcription intermediary factor 1 gamma antibodies in dermatomyositis patients Reviewed

    M. Ogawa-Momohara, Y. Muro, T. Mitsuma, M. Katayama, K. Yanaba, M. Nara, M. Kakeda, M. Kono, M. Akiyama

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY   Vol. 36 ( 6 ) page： 990 - 995   2018.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：CLINICAL & EXPER RHEUMATOLOGY  

    ObjectiveTranscription intermediary factor 1 gamma (TIF1 gamma) protein is known as a tumour suppressor that promotes cellular differentiation. Autoantibodies to TIF1 gamma. have a strong clinical association with cancers associated with dermatomyositis (DM). This study aims to identify the clinical characteristics of cancers in anti-..F1. antibody-positive adult patients with DM.MethodsThis retrospective analysis covered 160 adult DM patients who visited Nagoya University Hospital or collaborating medical centres between 2003 and 2016. Anti-TIF1 gamma antibody and other myositis-specific autoantibodies were detected by ELISA. Based on a review of medical charts, the cancers were staged according to the TNM Classification of Malignant Tumours of the Union for International Cancer Control and were divided into the two groups of " advanced" or " non-advanced" according to the stage classification.ResultsForty-one of the 160 (26%) patients had cancer. The incidence was significantly higher in the anti-TIF1 gamma-positive patients than in the anti-TIF1 gamma-negative patients (23/34= 68% vs. 18/126= 14%, p< 1x10(-6)). Anti-TIF1 gamma-positive patients with cancer were found more frequently in the "advanced" group than in the "non-advanced" group (21/23= 91% vs. 9/18= 50%, p< 0.0046). The intervals between DM diagnosis and cancer diagnosis were significantly shorter in the anti-TIF1 gamma-positive patients than in the anti-TIF1 gamma-negative patients (p= 0.047).ConclusionNot only did anti-TIF1 gamma antibodies correlate strongly with malignancy in DM patients, but cancers were also significantly more advanced in anti-TIF1 gamma-positive DM patients than in anti-TIF1 gamma-negative patients. Cancers in such cases were very frequently found close to the time of the DM diagnosis.

    Web of Science

  2. Myositis-specific and myositis-associated autoantibodies: their clinical characteristics and potential pathogenic roles. Invited Reviewed International journal

    Mariko Ogawa-Momohara, Yoshinao Muro

    Immunological medicine     page： 1 - 13   2024.10

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    In recent years, various myositis-specific and myositis-associated autoantibodies have been identified in idiopathic inflammatory myopathies, including dermatomyositis (DM), anti-synthetase syndrome (ASS), immune-mediated necrotizing myopathy (IMNM), and inclusion body myositis (IBM). These autoantibodies exhibit unique characteristics in terms of organ involvement, severity, and treatment response, making their understanding crucial for accurate diagnosis and effective therapy. This review provides a comprehensive overview of the clinical features of recently discovered myositis-specific and associated autoantibodies, while exploring their potential roles in the pathogenesis and exacerbation of myositis. Key findings include the production of anti-TIF1γ antibodies in model mice, the upregulation of Mi2-related genes in anti-Mi2 antibody-positive dermatomyositis muscle tissue, and Jo-1 antigen-induced T cell activation, shedding light on whether disease mechanisms are driven by autoantibodies or autoantigens.

    DOI： 10.1080/25785826.2024.2413604

    PubMed

  3. Keratinocyte derived extracellular vesicles mediated crosstalk between epidermis and dermis in UVB-induced skin inflammation. Reviewed International journal

    Yubin Li, Avital Baniel, DeAnna Diaz, Mariko Ogawa-Momohara, Cristina Ricco, Ahmed Eldaboush, Muhammad Bashir, Meena Sharma, Ming-Lin Liu, Victoria P Werth

    Cell communication and signaling : CCS   Vol. 22 ( 1 ) page： 461 - 461   2024.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    BACKGROUND AND RATIONALE: Ultraviolet-B (UVB) light induces dermal inflammation, although it is mostly absorbed in the epidermis. Recent reports suggest extracellular vesicles (EVs) act as a mediator of photodamage signaling. Melatonin is reported to be a protective factor against UV-induced damage. We hypothesized that EVs derived from UVB-irradiated keratinocytes might trigger proinflammatory responses in dermal cells and tested whether melatonin can ameliorate UVB-induced inflammation. METHODS: We used UVB-irradiated HaCaT cells, primary keratinocytes and STING knock-out mice to model production of EVs under photodamaging conditions and performed immunoblotting and ELISA to measure their effect on dermal macrophages. RESULTS: UVB-irradiated keratinocytes produce an increased number of EVs that contain higher concentrations of DNA and protein compared with controls. KC-derived EVs (KEVs) induced a STING- and inflammasome-mediated proinflammatory response in macrophages in vitro, and a pronounced inflammatory infiltrate in mouse dermis in vivo. Melatonin ameliorated KEVs inflammatory effect both in vitro and in vivo. CONCLUSIONS: This data suggests EVs are mediators in a crosstalk that takes place between keratinocytes and their neighboring cells as a result of photodamage. Further studies exploring EVs induced by damaging doses of UVB, and their impact on other cells will provide insight into photodamage and may help develop targeted therapeutic approaches.

    DOI： 10.1186/s12964-024-01839-9

    PubMed

  4. Correlation of serum allergen-specific IgE with total serum IgE and IgE specific to other allergens in Atopic dermatitis patients. Reviewed International journal

    Norika Akashi, Mariko Ogawa-Momohara, Tomoki Taki, Ryo Fukaura, Keiko Wakahara, Satoshi Kamiya, Yuta Yamashita, Haruka Koizumi, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama

    Journal of the European Academy of Dermatology and Venereology : JEADV   Vol. 38 ( 9 ) page： e761 - e763   2024.9

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/jdv.19872

    PubMed

  5. Pitfalls in the detection of anti-Nucleolar Organizer Region 90 (NOR90) antibodies. Reviewed International journal

    Satoshi Kamiya, Yoshinao Muro, Yuta Yamashita, Mariko Ogawa-Momohara, Masashi Akiyama

    European journal of internal medicine   Vol. 127   page： 157 - 160   2024.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ejim.2024.06.018

    PubMed

  6. Multiplexed mass cytometry of cutaneous lupus erythematosus and dermatomyositis skin: An in-depth, B cell directed immunoprofile. International journal

    Mariko Ogawa-Momohara, Thomas Vazquez, Felix Chin, Meena Sharma, Joshua Dan, Grant Sprow, Victoria P Werth

    The Journal of investigative dermatology     2024.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jid.2024.07.007

    PubMed

  7. Comment on: Longitudinal study of patients with anti-SAE antibody-positive dermatomyositis: a multicenter cohort study in China. Reviewed International journal

    Yuta Yamashita, Yoshinao Muro, Haruka Koizumi, Satoshi Kamiya, Norika Akashi, Mariko Ogawa-Momohara, Takuya Takeichi, Masashi Akiyama

    Rheumatology (Oxford, England)     2024.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/rheumatology/keae405

    PubMed

  8. Panniculitis on the trunk as a possible characteristic feature of anti-SAE1/2 antibody-positive dermatomyositis: A possible cutaneous manifestation of treatment resistance. Reviewed International journal

    Mahori Tago, Haruka Koizumi, Satoshi Kamiya, Norika Akashi, Akira Miyazaki, Yuta Yamashita, Mariko Ogawa-Momohara, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama

    The Journal of dermatology   Vol. 51 ( 7 ) page： e227 - e228   2024.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.17128

    PubMed

  9. Guideline for gynecological practice in Japan: Japan Society of Obstetrics and Gynecology and Japan Association of Obstetricians and Gynecologists 2023 edition.

    Nishio E, Ishitani K, Arimoto T, Igarashi T, Ishikawa T, Iwase A, Ogawa M, Ozawa N, Kajiyama H, Kawasaki K, Kudo R, Kumakiri J, Komura H, Komai K, Sato S, Shinohara K, Takahashi T, Tanaka K, Tanebe K, Deguchi M, Tozawa-Ono A, Nakashima A, Nakatsuka M, Hayakawa S, Hirata T, Fukuhara R, Miyakuni Y, Miyazaki H, Morisada T, Kuwabara Y, Takenaka M, Shozu M, Sugiura-Ogasawara M, Maeda T, Yokoyama Y, Fujii T

    The journal of obstetrics and gynaecology research   Vol. 50 ( 7 ) page： 1073 - 1094   2024.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/jog.15950

    PubMed

  10. Multiple subcutaneous reactive angioendotheliomatosis in a patient with antiphospholipid syndrome. Reviewed International journal

    Takashi Yokoyama, Masato Nakaguro, Mariko Ogawa-Momohara, Yoshihisa Nakano, Ryo Fukaura, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama

    Clinical and experimental dermatology     2024.6

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/ced/llae223

    PubMed

  11. ELISA detection of anti-eIF2B antibodies in Japanese patients with systemic sclerosis. Reviewed International journal

    Haruka Koizumi, Yasuhiko Yamano, Yoshinao Muro, Ryo Fukaura, Yuta Yamashita, Satoshi Kamiya, Norika Akashi, Mariko Ogawa-Momohara, Takuya Takeichi, Yasuhiro Kondoh, Masashi Akiyama

    Rheumatology (Oxford, England)   Vol. 63 ( 6 ) page： e164 - e165   2024.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/rheumatology/kead649

    PubMed

  12. Increased JAK activation in cutaneous vasculitis. Reviewed International journal

    Aoi Ebata, Mariko Ogawa-Momohara, Ryo Fukaura, Yuta Yamashita, Haruka Koizumi, Takuya Takeichi, Yoshinao Muro, Masashi Akiyama

    Journal of the American Academy of Dermatology   Vol. 90 ( 3 ) page： 627 - 629   2024.3

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jaad.2023.10.056

    PubMed

  13. 症例報告 特発性細菌性腹膜炎を合併した急性膵炎後の皮下結節性脂肪壊死症の1例

    天野 友里恵, 桃原 真理子, 竹内 想, 河野 通浩, 秋山 真志, 倉田 信彦, 植月 康太

    臨床皮膚科   Vol. 77 ( 11 ) page： 921 - 925   2023.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：株式会社医学書院  

    DOI： 10.11477/mf.1412207126

    CiNii Research

  14. Allergen-specific IgG4 increase in atopic dermatitis with long-term dupilumab use. Reviewed International journal

    Mariko Ogawa-Momohara, Yoshinao Muro, Chiaki Murase, Tomoki Taki, Kana Tanahashi, Yuta Yamashita, Haruka Koizumi, Ryo Fukaura, Takuya Takeichi, Masashi Akiyama

    The British journal of dermatology   Vol. 189 ( 4 ) page： 472 - 474   2023.9

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/bjd/ljad207

    PubMed

  15. Comment on: Successful treatment of rapid progressive interstitial lung disease in a case of anti-Zo antibody positive anti-synthetase syndrome. Reviewed International journal

    Haruka Koizumi, Yoshinao Muro, Satoshi Kamiya, Norika Akashi, Satoko Imai, Yuta Yamashita, Mariko Ogawa-Momohara, Takuya Takeichi, Masashi Akiyama

    International journal of rheumatic diseases   Vol. 26 ( 9 ) page： 1872 - 1873   2023.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1756-185X.14654

    PubMed

  16. Cutaneous manifestations of microscopic polyangiitis successfully controlled with avacopan alone. Reviewed International journal

    Satoshi Kamiya, Haruka Koizumi, Yuika Suzuki, Satoko Imai, Yuta Yamashita, Mariko Ogawa-Momohara, Takuya Takeichi, Yoshinao Muro, Kazushi Yasuda, Masashi Akiyama

    The Journal of dermatology   Vol. 50 ( 7 ) page： e206 - e207   2023.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.16726

    PubMed

    CiNii Research

  17. Successful combination therapy of bimekizumab and granulocyte monocyte adsorption apheresis for generalized pustular psoriasis complicated with microscopic polyangiitis. Reviewed International journal

    Rie Shukuin, Haruka Koizumi, Aoi Ebata, Satoko Imai, Yuta Yamashita, Mariko Ogawa-Momohara, Takuya Takeichi, Yoshinao Muro, Norito Takami, Masashi Akiyama

    The Journal of dermatology   Vol. 50 ( 6 ) page： e181 - e182   2023.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.16707

    PubMed

  18. Occurrence of cholangiocarcinoma, three years after negative seroconversion of anti-TIF1γ antibody, in a dermatomyositis patient. Reviewed International journal

    Ken Horisaki, Yoshinao Muro, Mariko Ogawa-Momohara, Yuta Yamashita, Haruka Koizumi, Takuya Takeichi, Masashi Akiyama

    European journal of dermatology : EJD   Vol. 33 ( 1 ) page： 48 - 49   2023.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1684/ejd.2023.4414

    PubMed

  19. Comment on: Disease evolution in a long-term follow-up of 104 undifferentiated connective tissue disease patients. Reviewed International journal

    Yuta Yamashita, Yoshinao Muro, Haruka Koizumi, Mariko Ogawa-Momohara, Takuya Takeichi, Masashi Akiyama

    Clinical and experimental rheumatology   Vol. 41 ( 1 ) page： 195 - 196   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.55563/clinexprheumatol/fnrck0

    PubMed

    CiNii Research

  20. A case of juvenile amyopathic dermatomyositis with anti-transcription intermediary factor 1-α antibody showing negative anti-TIF1-γ ELISA results: Comment on "Case of pembrolizumab-induced dermatomyositis with anti-transcription intermediary factor 1-γ antibody". Reviewed International journal

    Haruka Koizumi, Yoshinao Muro, Satoko Imai, Yuta Yamashita, Mariko Ogawa-Momohara, Takuya Takeichi, Megumi Murakami, Teruyuki Mitsuma, Masashi Akiyama

    The Journal of dermatology   Vol. 50 ( 1 ) page： e39 - e40   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/1346-8138.16587

    PubMed

    CiNii Research

  21. Appropriate immunoassay systems are needed to evaluate various anticentromere antibodies as biomarkers for disease progression in systemic sclerosis. Reviewed International journal

    Yoshinao Muro, Yuta Yamashita, Haruka Koizumi, Mariko Ogawa-Momohara, Takuya Takeichi, Masashi Akiyama

    Journal of immunological methods   Vol. 512   page： 113400 - 113400   2023.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jim.2022.113400

    PubMed

  22. Two novel anti-aminoacyl tRNA synthetase antibodies: Autoantibodies against cysteinyl-tRNA synthetase and valyl-tRNA synthetase. Reviewed International journal

    Yoshinao Muro, Yuta Yamashita, Haruka Koizumi, Mariko Ogawa-Momohara, Takuya Takeichi, Teruyuki Mitsuma, Masashi Akiyama

    Autoimmunity reviews   Vol. 21 ( 12 ) page： 103204 - 103204   2022.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    Anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies are useful for identifying a clinical subset of patients with inflammatory myopathies. Since the myositis of anti-ARS-positive patients is characterized by a unique set of non-myopathic manifestations, including interstitial lung disease, mechanic's hands, and arthralgia, the patients are classified as having anti-synthetase syndrome. Autoantibodies have been identified to eight kinds of ARSs. Of the other 12 ARSs, eight are components of the "OJ" multi-synthetase complex. Autoantibodies to the four remaining ARSs (CysARS, ValARS, SerARS, and TrpARS) have not been reported to be present in patients with inflammatory myopathies. In this study, we first screened samples from more than 300 Japanese patients majorly consisting of those with dermatomyositis (DM) by our established in-house ELISA to find autoantibodies against the four ARSs described above. Since sera from two DM patients specifically reacted to CysARS or ValARS, we determined their reactivities by immunoprecipitation (IP) with the corresponding recombinant proteins and IP-Western blotting with cellular extract. One patient had several features found in anti-synthetase syndrome, but the other did not. The clinical differences among the various anti-ARS antibodies should be explored in a future work.

    DOI： 10.1016/j.autrev.2022.103204

    PubMed

  23. Clinical significance of anti-NOR90 antibodies in systemic sclerosis and idiopathic interstitial pneumonia Reviewed International journal

    Yuta Yamashita, Yasuhiko Yamano, Yoshinao Muro, Mariko Ogawa-Momohara, Takuya Takeichi, Yasuhiro Kondoh, Masashi Akiyama

    RHEUMATOLOGY   Vol. 61 ( 4 ) page： 1709 - 1716   2022.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：OXFORD UNIV PRESS  

    Objective Anti-NOR90 antibodies are usually found in patients with SSc; however, their clinical relevance remains obscure. We developed an ELISA for measuring them to investigate the clinical features of patients with anti-NOR90 antibodies. Methods Serum samples from 1252 patients with various conditions from Nagoya University Hospital and 244 patients with idiopathic interstitial pneumonia (IIP) from Tosei General Hospital were included. Anti-NOR90 antibodies were assayed by an ELISA using the recombinant protein produced by in vitro transcription/translation. Results Five (0.4%) patients in the Nagoya University Hospital cohort had anti-NOR90 antibodies. One patient with diffuse cutaneous SSc, three with limited cutaneous SSc, and one with Raynaud's disease were positive for anti-NOR90 antibodies. Anti-NOR90 antibodies were found more frequently in patients with systemic scleroderma-spectrum disorders (SSDs) than without SSDs (5/316 vs 0/936, P <0.00101) and were found more frequently in patients with SSc than without SSc (4/249 vs 0/528, P <0.0104) in the systemic autoimmune rheumatic diseases cohort. Three of the four anti-NOR90-positive SSc patients had interstitial lung disease (ILD), and two of those four had cancer. Three (1.2%) patients in the Tosei General Hospital cohort had anti-NOR90 antibodies. All three of the anti-NOR90-positive IIP patients had gastrointestinal tract involvement, and two of those three had cancer or skin lesions observed in SSc. Conclusions Although anti-NOR90 antibodies are rarely found in clinics, our ELISA is useful for their detection. Further studies are needed to confirm the association of anti-NOR90 antibodies with ILD and cancer in SSc and IIP patients.

    DOI： 10.1093/rheumatology/keab575

    Web of Science

    PubMed

  24. Anti-Zo antibodies in Japanese myositis patients detected by a newly developed ELISA. Reviewed International journal

    Yoshinao Muro, Takako Hashimoto, Shinyu Izumi, Mariko Ogawa-Momohara, Takuya Takeichi, Hiroyuki Yamashita, Hidekata Yasuoka, Masashi Akiyama

    Clinical and experimental rheumatology   Vol. 40 ( 2 ) page： 219 - 223   2022.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：CLINICAL & EXPER RHEUMATOLOGY  

    OBJECTIVES: The myositis-specific autoantibodies that characterise certain forms of idiopathic inflammatory myopathy (IIM) are useful for diagnosing dermatomyositis (DM) / polymyositis (PM) and predicting its prognosis. The autoantibody to phenylalanyl-tRNA synthetase (anti-Zo) has been identified as a disease marker antibody for anti-synthetase syndrome only in a UK cohort. Here we aim to establish an ELISA for the measurement of anti-Zo and to characterise the clinical features of Japanese patients who have this autoantibody. METHODS: Anti-Zo was investigated by immunoprecipitation with recombinant phenylalanyl-tRNA synthetase α/β proteins. The results were confirmed by immunoprecipitation-Western blotting with cell extract. Sera from patients with DM/PM (n=224) were screened by an ELISA with the recombinant proteins. Medical records were retrospectively reviewed to obtain detailed information on the clinical phenotypes of the anti-Zo-positive patients. RESULTS: Only two male patients were confirmed to have anti-Zo. Both patients had fever, myopathy, interstitial lung disease, and mechanic's hands, and these clinical features are consistent with those of anti-synthetase syndrome. Another patient's serum showed a higher level than the cut-off value for anti-phenylalanyl-tRNA synthetase α by our in-house ELISA, but was judged to be negative for anti-Zo by immunoprecipitation-Western blotting. CONCLUSIONS: This is the first report of anti-Zo-positive IIM patients from Asia. Although Japanese patients with anti-Zo have a clinical phenotype similar to that of Caucasian patients, further large cohort studies are necessary to confirm the frequency of anti-Zo in Japanese IIM patients. Our newly developed ELISA should be validated for sensitivity and specificity in large cohorts.

    DOI： 10.55563/clinexprheumatol/q70vmh

    Web of Science

    PubMed

    CiNii Research

  25. Response to: 'Anti-Ku antibodies: important points to consider' by Mahler et al International journal

    Mariko Ogawa-Momohara, Yoshinao Muro, Masashi Akiyama

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 80 ( 11 ) page： e183   2021.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：BMJ PUBLISHING GROUP  

    DOI： 10.1136/annrheumdis-2019-216595

    Web of Science

    Scopus

    PubMed

  26. Overlap of systemic lupus erythematosus and myositis is rare in anti-Ku antibody-positive patients Reviewed International journal

    Mariko Ogawa--Momohara, Yoshinao Muro, Masashi Akiyama

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 80 ( 9 ) page： e147   2021.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：BMJ PUBLISHING GROUP  

    DOI： 10.1136/annrheumdis-2019-216375

    Web of Science

    Scopus

    PubMed

  27. Immune recognition of lysyl-tRNA synthetase and isoleucyl-tRNA synthetase by anti-OJ antibody-positive sera Reviewed International journal

    Yoshinao Muro, Yasuhiko Yamano, Ken Yoshida, Yohsuke Oto, Kimiko Nakajima, Teruyuki Mitsuma, Shiori Kikuchi, Akihiro Matsumae, Mariko Ogawa-Momohara, Takuya Takeichi, Yasuhiro Kondoh, Masao Katayama, Yasuyuki Todoroki, Yoshiya Tanaka, Minoru Satoh, Masashi Akiyama

    JOURNAL OF AUTOIMMUNITY   Vol. 122   page： 102680 - 102680   2021.8

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD  

    Objective: Anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies are useful for identifying a clinical subset of patients with idiopathic inflammatory myopathies (IIMs). Anti-OJ antibodies, which recognize multi-enzyme synthetase complexes including isoleucyl-tRNA synthetase (IARS) and lysyl-tRNA synthetase (KARS), are among the anti-ARS antibodies. Although testing antibodies to other ARSs have been used clinically, no validated immunoassays for detecting anti-OJ antibodies are available. We aimed to establish an anti-OJ ELISA. Methods: Serum samples were collected from 279 patients with IIMs and 22 patients with idiopathic interstitial pneumonia. Sixty-four of the samples that had been confirmed to be negative for anti-OJ by standard immunoprecipitation were used as the negative control, and 12 anti-OJ-positive reference sera were used as the positive control. Antibodies to IARS and KARS were assayed by ELISA using biotinylated recombinant proteins generated by in vitro transcription/translation. Results: The anti-OJ-positive sera strongly reacted with the KARS and IARS recombinant proteins in ELISA. Although all 12 reference sera were positive in the anti-KARS ELISA, 4 of the 64 anti-OJ-negative sera were also weakly positive. The sensitivity and the specificity were 100% and 93.8%, respectively. Since our anti-KARS ELISA performed well, showing a high agreement with the results for immunoprecipitation (Cohen's kappa > 0.8), the remaining 237 samples were also tested. Thirteen anti-KARS-positive sera were newly found by ELISA, all of which were anti-OJ positive by immunoprecipitation. Conclusion: Immunoassays for detecting anti-OJ antibodies using KARS and IARS recombinant proteins were developed. Our ELISAs performed well, with very high agreement of the results by immunoprecipitation and can be applied to the first reliable, easy-to-use measurement assays for anti-OJ antibodies.

    DOI： 10.1016/j.jaut.2021.102680

    Web of Science

    PubMed

  28. Autoantibody profiles in patients' sera associated with distribution patterns of dermatomyositis skin symptoms. Reviewed International journal

    Mariko Ogawa-Momohara, Fumie Kinoshita, Yoshinao Muro, Yumiko Kobayashi, Takuya Takeichi, Masashi Akiyama

    Journal of the American Academy of Dermatology   Vol. 84 ( 6 ) page： 1720 - 1722   2021.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jaad.2020.07.131

    PubMed

  29. ANCA-associated neuropathy in systemic sclerosis: A case report and review of literature Reviewed

    Kayo Takenaka, Takuya Takeichi, Ryoji Nishi, Masashi Suzuki, Haruki Koike, Masahisa Katsuno, Mariko Ogawa-Momohara, Yoshinao Muro, Masashi Akiyama

    JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY   Vol. 4 ( 2 ) page： 34 - 36   2021.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JOHN WILEY & SONS LTD  

    Systemic sclerosis (SSc) is a multi-system autoimmune disease. Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed against enzymes found within primary granules of neutrophils and lysosomes in monocytes. Although up to 12% of SSc patients have ANCA, only a minority of these patients develop an overlap syndrome with ANCA-associated vasculitis. We summarize previous reports on SSc patients with ANCA-associated neuropathy. In all the reported cases, the SSc diagnosis preceded the ANCA-associated neuropathy diagnosis. Seven of the eight patients with limited cutaneous SSc had interstitial lung disease (ILD). Thus, patients with ANCA-associated neuropathy in lSSc may be prone to complication with ILD.

    DOI： 10.1002/cia2.12153

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  30. Morphea in a Crohn's disease patient undergoing ustekinumab treatment Reviewed International journal

    Misako Makihara-Inukai, Takuya Takeichi, Mariko Ogawa-Momohara, Yoshinao Muro, Masashi Akiyama

    EUROPEAN JOURNAL OF DERMATOLOGY   Vol. 31 ( 1 ) page： 96 - 97   2021.2

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    DOI： 10.1684/ejd.2020.3956

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  31. A case with overlapping features of IgG4-related autoimmune pancreatitis, Sjogren's syndrome and anti-aminoacyl-tRNA synthetase syndrome Reviewed International journal

    Masato Yoshikawa, Yoshinao Muro, Mariko Ogawa-Momohara, Satoru Ito, Takuya Takeichi, Masashi Akiyama

    MODERN RHEUMATOLOGY CASE REPORTS   Vol. 5 ( 1 ) page： 82 - 86   2021.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：TAYLOR & FRANCIS LTD  

    A 55-year-old man who had been diagnosed with autoimmune pancreatitis five years earlier was referred to our department because of finger swelling, finger stiffness and the presence of interstitial lung disease (ILD). The patient was diagnosed with Sjogren's syndrome according to the pathological findings of minor salivary glands and positive anti-SS-A antibodies. Later, at age 58, he was hospitalised due to the exacerbation of the ILD. Serum IgG4 level was checked and was found to be elevated (417 mg/dL). After the introduction of cyclosporine in addition to the prednisolone, at age 60, the ILD disease activity stabilised. However, at age 62, fever, myalgia and mechanic's hands appeared. His serum creatine kinase level was high, and magnetic resonance imaging showed inflammatory findings of muscle. In-house ELISA clarified that his serum carried anti-PL-7 antibody among anti-aminoacyl-tRNA synthetase antibodies. This is a unique case who had overlapping features of IgG4-related autoimmune pancreatitis, Sjogren's syndrome and anti-synthetase syndrome. Although the aetiology of the complications in this patient is obscure, autoimmunity might have played a significant role in the disease conditions and prognosis of the present case with IgG4-related disease.

    DOI： 10.1080/24725625.2020.1816675

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  32. 2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases International journal

    Yoshiya Tanaka, Masataka Kuwana, Takao Fujii, Hideto Kameda, Yoshinao Muro, Keishi Fujio, Yasuhiko Itoh, Hidekata Yasuoka, Shusaku Fukaya, Konomi Ashihara, Daisuke Hirano, Koichiro Ohmura, Yuya Tabuchi, Hisanori Hasegawa, Ryo Matsumiya, Yuichiro Shirai, Takehisa Ogura, Yumi Tsuchida, Mariko Ogawa-Momohara, Hidehiko Narazaki, Yoshino Inoue, Ippei Miyagawa, Kazuhisa Nakano, Shintaro Hirata, Masaaki Mori

    MODERN RHEUMATOLOGY   Vol. 31 ( 1 ) page： 29 - 33   2021.1

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    Objective: To update and revise the diagnostic criteria for mixed connective tissue disease (MCTD) issued by the Japan Research Committee of the Ministry of Health, Labor, and Welfare (MHLW), a round table discussion by experts from rheumatology, dermatology, and pediatric medicine was conducted in multiple occasions. Methods: The definition of MCTD, and items included in the diagnostic criteria were generated by consensus method and evaluation using clinical data of typical and borderline cases of MCTD, by applying to the diagnostic criteria for MCTD proposed in 1996 and 2004 by the Research Committee of MHLW. Results: To the end, all committee members reached consensus. Then, the criteria were assessed in an independent validation cohort and tested against preexisting criteria. The revised criteria facilitate an understanding of the overall picture of this disease by describing the concept of MCTD, common manifestations, immunological manifestation and characteristic organ involvement. Conditions with characteristic organ involvement include pulmonary arterial hypertension, aseptic meningitis and trigeminal neuropathy. Even if the overlapping manifestations are absent, MCTD can be diagnosed based on the presence of the characteristic organ involvement. Furthermore, the criteria were validated for applicability in actual clinical cases, and public comments were solicited from the Japan College of Rheumatology and other associated societies. Conclusion: After being reviewed through public comments, the revised diagnostic criteria have been finalized.

    DOI： 10.1080/14397595.2019.1709944

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  33. A case of systemic lupus erythematosus/systemic sclerosis overlap syndrome successfully treated with belimumab Reviewed International journal

    Mami Hara, Mariko Ogawa-Momohara, Yoshinao Muro, Takuya Takeichi, Masashi Akiyama

    EUROPEAN JOURNAL OF DERMATOLOGY   Vol. 30 ( 5 ) page： 615 - 617   2020.10

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    DOI： 10.1684/ejd.2020.3868

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  34. Clinical and serological features of dermatomyositis and systemic lupus erythematosus patients with autoantibodies to ADAR1 Reviewed International journal

    Yoshinao Muro, Mariko Ogawa-Momohara, Takuya Takeichi, Shusaku Fukaya, Hidekata Yasuoka, Michihiro Kono, Masashi Akiyama

    JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 100 ( 1 ) page： 82 - 84   2020.10

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

    DOI： 10.1016/j.jdermsci.2020.08.008

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  35. Reducing immunosuppressant use in patients with chronic inflammation during the COVID-19 pandemic: Risks versus benefits Reviewed

    Mariko Ogawa-Momohara, Yoshinao Muro, Takuya Takeichi, Masashi Akiyama

    JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY   Vol. 3 ( 5 ) page： 120 - 121   2020.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：JOHN WILEY & SONS LTD  

    During the COVID-19 pandemic, clinicians are facing a difficult but important question: Should we try to reduce immunosuppressant use or postpone immunosuppressant therapies for newly diagnosed autoimmune disease patients with mild to moderate symptoms? We would like to alert your readership that although potential chronic inflammation itself is not always critical, it can trigger a hyper-inflammatory condition in patients who become infected with COVID-19. We should be careful when reducing immunosuppressant use.

    DOI： 10.1002/cia2.12132

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  36. A single-centre cohort study on cutaneous manifestations of antinuclear matrix protein 2 antibody-positive dermatomyositis. Reviewed International journal

    S Okochi, M Ogawa-Momohara, Y Muro, M R Dittmer, M Akiyama

    Clinical and experimental dermatology   Vol. 45 ( 5 ) page： 591 - 593   2020.7

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

    DOI： 10.1111/ced.14152

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  37. Subacute cutaneous lupus erythematosus with melanocyte elimination induced by pembrolizumab Reviewed International journal

    Mariko Ogawa-Momohara, Yoshinao Muro, Katsunobu Goto, Chikashi Obuse, Minoru Satoh, Michihiro Kono, Masashi Akiyama

    JOURNAL OF DERMATOLOGY   Vol. 47 ( 6 ) page： e217 - e219   2020.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

    DOI： 10.1111/1346-8138.15316

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  38. sQUIZ your knowledge: Multiple subcutaneous nodules symmetrically located on tendinous regions Reviewed International journal

    Naohiro Hokari, Mariko Ogawa-Momohara, Masashi Akiyama

    EUROPEAN JOURNAL OF DERMATOLOGY   Vol. 30 ( 2 ) page： 226 - 227   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：JOHN LIBBEY EUROTEXT LTD  

    DOI： 10.1684/ejd.2020.3803

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  39. Remodelling of calcinosis cutis in a patient with scleroderma overlap syndrome. Reviewed International journal

    M R Dittmer, M Ogawa-Momohara, Y Muro, M Kono, M Akiyama

    Journal of the European Academy of Dermatology and Venereology : JEADV   Vol. 34 ( 1 ) page： e20-e21 - E21   2020.1

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

    DOI： 10.1111/jdv.15864

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  40. Clinical characteristics of anti-Ro52 alpha and anti-Ro52 beta antibodies in dermatomyositis/polymyositis Reviewed International journal

    Mariko Ogawa-Momohara, Yoshinao Muro, Teruyuki Mitsuma, Masao Katayama, Koichi Yanaba, Mizuho Nara, Masato Kakeda, Masashi Akiyama

    JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 96 ( 1 ) page： 50 - 52   2019.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER IRELAND LTD  

    DOI： 10.1016/j.jdermsci.2019.08.002

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  41. Anti-Mi-2 antibody titers and cutaneous manifestations in dermatomyositis Reviewed

    Mariko Ogawa-Momohara, Yoshinao Muro, Masashi Akiyama

    JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY   Vol. 2 ( 2 ) page： 49 - 52   2019.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：JOHN WILEY & SONS LTD  

    The anti-Mi-2 antibody is a dermatomyositis (DM)-specific autoantibody. It is thought to be associated with photosensitivity in patients with DM because higher expression levels of Mi-2 antigens have been found in UV-irradiated cultured cells and because epidemiological studies have supported this association. This study aims to identify the relations between anti-Mi-2 antibody titers measured by ELISA and clinical characteristics in patients with DM. We focused on analyzing associations between anti-Mi-2 antibody titers and cutaneous manifestations. This retrospective analysis covered 160 adult DM patients. Anti-Mi-2 antibodies were detected by an in-house ELISA, and anti-Mi-2 titers were measured by a manufactured ELISA. Twelve of the 160 (7.5%) patients were anti-Mi-2 positive. The anti-Mi-2-positive patients showed extremely elevated muscle enzyme levels (P < 0.0001), less frequent interstitial lung disease complication (P = 0.031), and favorable survival rate (100%) (P = 0.07). No correlations were found between anti-Mi-2 antibody titers and clinical characteristics or skin manifestations, including photosensitive rashes. Further investigation is necessary to elucidate the pathological significance of the anti-Mi-2 antibody in DM.

    DOI： 10.1002/cia2.12048

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  42. Acrodermatitis continua of Hallopeau with dense infiltration of IgG4-positive cells in the lesional dermis. Reviewed International journal

    M Ogawa-Momohara, Y Muro, M Nakaguro, T Takeichi, M Kono, M Akiyama

    The British journal of dermatology   Vol. 180 ( 4 ) page： 941 - 942   2019.4

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

    DOI： 10.1111/bjd.17405

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  43. Prognosis of dysphagia in dermatomyositis.

    Ogawa-Momohara M, Muro Y, Kono M, Akiyama M

    Clinical and experimental rheumatology   Vol. 37 ( 1 ) page： 165   2019.1

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  44. Prognosis of dysphagia in dermatomyositis Reviewed

    M. Ogawa-Momohara, Y. Muro, M. Kono, M. Akiyama

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY   Vol. 37 ( 1 ) page： 165 - 165   2019.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：CLINICAL & EXPER RHEUMATOLOGY  

    Web of Science

  45. Prognosis of dysphagia in dermatomyositis

    Ogawa-Momohara M.

    Clinical and Experimental Rheumatology   Vol. 37 ( 1 ) page： .   2019

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    Scopus

  46. Strong correlation between cancer progression and anti-transcription intermediary factor 1γ antibodies in dermatomyositis patients

      Vol. 36 ( 6 ) page： 990-995   2018.11

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  47. Strong correlation between cancer progression and anti-transcription intermediary factor 1γ antibodies in dermatomyositis patients.

    Ogawa-Momohara M, Muro Y, Mitsuma T, Katayama M, Yanaba K, Nara M, Kakeda M, Kono M, Akiyama M

    Clinical and experimental rheumatology   Vol. 36 ( 6 ) page： 990 - 995   2018.11

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  48. Splicing variant of WDFY4 augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis Reviewed

    Yuta Kochi, Yoichiro Kamatani, Yuya Kondo, Akari Suzuki, Eiryo Kawakami, Ryosuke Hiwa, Yukihide Momozawa, Manabu Fujimoto, Masatoshi Jinnin, Yoshiya Tanaka, Takashi Kanda, Robert G. Cooper, Hector Chinoy, Simon Rothwell, Janine A. Lamb, Jiri Vencovsky, Herman Mann, Koichiro Ohmura, Keiko Myouzen, Kazuyoshi Ishigaki, Ran Nakashima, Yuji Hosono, Hiroto Tsuboi, Hidenaga Kawasumi, Yukiko Iwasaki, Hiroshi Kajiyama, Tetsuya Horita, Mariko Ogawa-Momohara, Akito Takamura, Shinichiro Tsunoda, Jun Shimizu, Keishi Fujio, Hirofumi Amano, Akio Mimori, Atsushi Kawakami, Hisanori Umehara, Tsutomu Takeuchi, Hajime Sano, Yoshinao Muro, Tatsuya Atsumi, Toshihide Mimura, Yasushi Kawaguchi, Tsuneyo Mimori, Atsushi Takahashi, Michiaki Kubo, Hitoshi Kohsaka, Takayuki Sumida, Kazuhiko Yamamoto

    ANNALS OF THE RHEUMATIC DISEASES   Vol. 77 ( 4 ) page： 602 - 611   2018.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：BMJ PUBLISHING GROUP  

    Objectives Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases in which both genetic and environmental factors play important roles. To identify genetic factors of IIM including polymyositis, dermatomyositis (DM) and clinically amyopathic DM (CADM), we performed the first genome-wide association study for IIM in an Asian population.Methods We genotyped and tested 496 819 single nucleotide polymorphism for association using 576 patients with IIM and 6270 control subjects. We also examined the causal mechanism of disease-associated variants by in silico analyses using publicly available data sets as well as by in in vitro analyses using reporter assays and apoptosis assays.Results We identified a variant in WDFY4 that was significantly associated with CADM (rs7919656; OR=3.87; P=1.5x10(-8)). This variant had a cis-splicing quantitative trait locus (QTL) effect for a truncated WDFY4isoform (tr-WDFY4), with higher expression in the risk allele. Transexpression QTL analysis of this variant showed a positive correlation with the expression of NF-B associated genes. Furthermore, we demonstrated that both WDFY4 and tr-WDFY4 interacted with pattern recognition receptors such as TLR3, TLR4, TLR9 and MDA5 and augmented the NF-B activation by these receptors. WDFY4 isoforms also enhanced MDA5-induced apoptosis to a greater extent in the tr-WDFY4-transfected cells.Conclusions As CADM is characterised by the appearance of anti-MDA5 autoantibodies and severe lung inflammation, the WDFY4 variant may play a critical role in the pathogenesis of CADM.

    DOI： 10.1136/annrheumdis-2017-212149

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  49. Pansclerotic morphea associated with hypohidrosis and anti-M3 muscarinic acetylcholine receptor antibodies Reviewed

    H. Fujita-Tanaka, Y. Ogawa, Y. Muro, M. Ogawa-Momohara, H. Asashima, H. Tsuboi, T. Sumida, M. Akiyama

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 178 ( 3 ) page： E210 - E211   2018.3

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY  

    DOI： 10.1111/bjd.16021

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  50. Autoantibodies to Su/Argonaute 2 in Japanese patients with inflammatory myopathy Reviewed

    Mariko Ogawa-Momohara, Yoshinao Muro, Minoru Satoh, Masashi Akiyama

    CLINICA CHIMICA ACTA   Vol. 471   page： 304 - 307   2017.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

    Backgrozrnd: Anti-Su antibodies are found in 5-20% of cases of various systemic autoimmune rheumatic diseases and in 5-10% of dermatomyositis (DM)/polymyositis (PM) patients. In 2006, the 100 kDa Su antigen was identified as argonaute2 (Ago2), and it was found to play a major role in RNA interference. However, immunoprecipitation (IP) remains the main method for detecting anti-Su and the clinical significance of the antibodies is uncertain.Methods: Sera from patients with DM/PM (n = 224) were screened by an ELISA that uses recombinant biotinylated Ago2 protein. Some serum samples were tested by IP and by indirect immunofluorescence (DP) analysis.Results: Seventeen (7.5%, 17/224) sera from DM/PM were positive in ELISA. Of the 33 IP-tested sera (17 ELISApositive and 16 ELISA-negative with high background), 13 were found to be anti-Ago2/Su-positive in IP and ELISA. Only one IP-positive serum was judged to be ELISA-negative. Among the 13 patients with anti-Su/Ago2, 7 cases also had myositis-specific autoantibodies. Six sera that were positive by both IP and ELISA showed the GW body pattern in IIF. Interestingly, one ELISA-positive serum with an inconclusive result in IP also showed the GW body pattern.Conclusion: Our novel ELISA appears to be useful for screening anti-Su/Ago2 antibodies (sensitivity: 93%, specificity: 79%).

    DOI： 10.1016/j.cca.2017.06.022

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  51. Ortner's syndrome caused by pulmonary arterial hypertension associated with mixed connective tissue disease.

    Ogawa-Momohara M, Muro Y, Hirashiki A, Fujimoto Y, Kondo T, Akiyama M

    Clinical and experimental rheumatology   Vol. 34 ( 6 ) page： 1125   2016.11

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  52. Ortner's syndrome caused by pulmonary arterial hypertension associated with mixed connective tissue disease Reviewed

    M. Ogawa-Momohara, Y. Muro, A. Hirashiki, Y. Fujimoto, T. Kondo, M. Akiyama

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY   Vol. 34 ( 6 ) page： 1125 - 1125   2016.11

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    Web of Science

  53. Successful topical adapalene treatment for the facial lesions of an adolescent case of epidermolytic ichthyosis. Reviewed International journal

    Mariko Ogawa, Masashi Akiyama

    Journal of the American Academy of Dermatology   Vol. 71 ( 3 ) page： e103 - 5   2014.9

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.jaad.2014.04.010

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To the head of Papers.▲

MISC 49

  1. 【皮膚科領域の自己抗体】筋炎と自己抗体

    桃原 真理子

    皮膚科   Vol. 5 ( 3 ) page： 261 - 267   2024.3

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    Language：Japanese   Publisher：(有)科学評論社  

  2. 早期治療介入が間質性肺炎に著効した抗PM/Scl抗体陽性皮膚筋炎の1例

    加藤 史織, 桃原 真理子, 山下 雄太, 小泉 遼, 武市 拓也, 室 慶直, 秋山 真志, 星野 慶

    日本皮膚科学会雑誌   Vol. 134 ( 2 ) page： 345 - 346   2024.2

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    Language：Japanese   Publisher：(公社)日本皮膚科学会  

  3. 自己免疫性多内分泌腺症候群3A型に併発した円形脱毛症をバリシチニブにて治療した1例

    後藤 文音, 山下 雄太, 小泉 遼, 桃原 真理子, 武市 拓也, 室 慶直, 秋山 真志, 湯浅 淳

    日本皮膚科学会雑誌   Vol. 134 ( 2 ) page： 350 - 350   2024.2

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    J-GLOBAL

  4. 血清抗BP180抗体が陽性であった疱疹状膿痂疹の1例

    服部いくみ, 小泉遼, 神谷怜志, 明石憲佳, 野田達弘, 山下雄太, 桃原真理子, 武市拓也, 室慶直, 秋山真志

    日本皮膚科学会雑誌   Vol. 134 ( 5 )   2024

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  5. デュピルマブの長期使用によるアトピー性皮膚炎におけるアレルゲン特異的IgG4の増加

    桃原 真理子, 室 慶直, 村瀬 千晶, 滝 奉樹, 棚橋 華奈, 山下 雄太, 小泉 遼, 深浦 遼, 武市 拓也, 秋山 真志

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   Vol. 53回   page： 203 - 203   2023.12

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    Language：Japanese   Publisher：(一社)日本皮膚免疫アレルギー学会  

  6. 特発性細菌性腹膜炎を合併した急性膵炎後の皮下結節性脂肪壊死症の1例

    天野 友里恵, 桃原 真理子, 竹内 想, 河野 通浩, 秋山 真志, 倉田 信彦, 植月 康太

    臨床皮膚科   Vol. 77 ( 11 ) page： 921 - 925   2023.10

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    Language：Japanese   Publisher：(株)医学書院  

    ＜文献概要＞50歳,女性.初診7か月前に自己免疫性肝炎による非代償性肝硬変と診断されていた.初診1週間前に生体肝移植を行うため入院,その翌日に上腹部痛が出現し,急性膵炎を発症した.抗菌薬治療で膵酵素は改善傾向になったが,採血上炎症反応の上昇を認め,特発性細菌性腹膜炎と診断された.数日後,両下腿に有痛性の皮下結節が多数出現した.病理組織像として脂肪細胞は"ghost-like cell"の形状を呈し,脂肪小葉は壊死に陥っており,皮下結節性脂肪壊死症と診断した.本疾患は膵疾患に合併することが知られているが,自験例のような感染症合併例においては皮膚症状から細菌の血行性播種による二次性脂肪織炎も鑑別に挙がる.臨床症状からだけでは確定診断は困難であり,皮膚生検検体の病理所見と組織培養が確定診断に重要である

    Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01559&link_issn=&doc_id=20231012280019&doc_link_id=10.11477%2Fmf.1412207126&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1412207126&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  7. 【皮膚筋炎とその周辺】筋炎のオーバーラップ症候群

    桃原 真理子

    皮膚科   Vol. 3 ( 1 ) page： 66 - 72   2023.1

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  8. 疥癬トンネル内におけるヒゼンダニ虫体および虫卵の走査型電顕観察

    村瀬千晶, 深浦遼, 桃原真理子, 秋山真志

    皮膚かたち研究学会学術大会プログラム・抄録集   Vol. 49th   2023

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  9. 当科における好酸球性多発血管炎性肉芽腫症に対するメポリズマブの使用経験と有効性の検討

    山下 雄太, 室 慶直, 小泉 遼, 桃原 真理子, 武市 拓也, 秋山 真志

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   Vol. 52回   page： 217 - 217   2022.12

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    Language：Japanese   Publisher：(一社)日本皮膚免疫アレルギー学会  

  10. 当科における好酸球性多発血管炎性肉芽腫症に対するメポリズマブの使用経験と有効性の検討

    山下 雄太, 室 慶直, 小泉 遼, 桃原 真理子, 武市 拓也, 秋山 真志

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   Vol. 52回   page： 217 - 217   2022.12

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  11. 膠原病の新知見 皮膚エリテマトーデスの最新知見

    桃原 真理子

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   Vol. 52回   page： 74 - 74   2022.12

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  12. 膠原病の新知見 皮膚エリテマトーデスの最新知見

    桃原 真理子

    日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集   Vol. 52回   page： 74 - 74   2022.12

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    Language：Japanese   Publisher：(一社)日本皮膚免疫アレルギー学会  

  13. Lenabasum, a Cannabinoid Type 2 Receptor Agonist, Activates Diverse Cell-specific Pathways in Whole Blood Leukocytes in Dermatomyositis

    Nilesh Kodali, Thomas Vazquez, DeAnna Diaz, Josh Dan, Grant Sprow, Rohan Dhiman, Mariko Ogawa-Momohara, Muhammad Bashir, Meena Sharma, Victoria Werth

    ARTHRITIS & RHEUMATOLOGY   Vol. 74   page： 3674 - 3677   2022.9

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：WILEY  

    Web of Science

  14. Plasmacytoid Dendritic Cells Are Not Major Producers of Type 1 Interferons in Cutaneous Lupus

    Thomas Vazquez, Nilesh Kodali, DeAnna Diaz, Jay Patel, Emily Keyes, Grant Sprow, Meena Sharma, Mariko Ogawa-Momohara, Madison Grinnell, Josh Dan, Victoria Werth

    ARTHRITIS & RHEUMATOLOGY   Vol. 74   page： 4508 - 4510   2022.9

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：WILEY  

    Web of Science

  15. Multiplexed Mass Cytometry of Cutaneous Lupus Erythematosus and Dermatomyositis Skin: An In-depth B Cell Directed Immunoprofile Reviewed International journal

    Mariko Ogawa-Momohara, Thomas Vazquez, Meena Sharma, Josh Dan, Grant Sprow, Victoria Werth

    ARTHRITIS & RHEUMATOLOGY   Vol. 74   page： 658 - 660   2022.9

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    Authorship：Lead author   Language：English   Publisher：WILEY  

    DOI： 10.1016/j.jid.2024.07.007

    Web of Science

    PubMed

  16. 四肢関節背面と臀裂部にも皮疹を呈した抗ARS抗体陽性皮膚筋炎の1例

    牧原 実紗子, 桃原 真理子, 武市 拓也, 室 慶直, 秋山 真志

    日本皮膚科学会雑誌   Vol. 131 ( 8 ) page： 1894 - 1894   2021.7

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  17. 全身性強皮症との鑑別を要したPalmar fasciitis and polyarthritis syndromeの1例

    山下 雄太, 室 慶直, 福澤 沙麗, 桃原 真理子, 武市 拓也, 秋山 真志

    日本皮膚科学会雑誌   Vol. 131 ( 5 ) page： 1402 - 1402   2021.5

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  18. ウステキヌマブ投与中のクローン病患者に生じた限局性強皮症

    牧原 実紗子, 武市 拓也, 桃原 真理子, 室 慶直, 秋山 真志

    日本皮膚科学会雑誌   Vol. 131 ( 1 ) page： 113 - 113   2021.1

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  19. シェーグレン症候群の経過中に抗U1-RNP抗体の陽転化と肺高血圧症の発症を認めた2症例

    玉腰 和, 桃原 真理子, 吉田 雅博, 室 慶直, 武市 拓也, 秋山 真志, 中野 嘉久

    日本皮膚科学会雑誌   Vol. 131 ( 1 ) page： 113 - 113   2021.1

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  20. ベリムマブが奏功したSLE/強皮症overlap症候群の1例

    原 真望, 桃原 真理子, 武市 拓也, 室 慶直, 秋山 真志

    日本皮膚科学会雑誌   Vol. 130 ( 9 ) page： 2090 - 2090   2020.8

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  21. 重篤な急性肝不全を来した骨髄性プロトポルフィリン症の1例

    鈴木 由以佳, 桃原 真理子, 秋山 真志, 小倉 靖弘, 清水 真

    日本皮膚科学会雑誌   Vol. 130 ( 9 ) page： 2091 - 2091   2020.8

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  22. 顔面・両下肢に紫斑を認めたIgA血管炎の1例

    竹中 花予, 桃原 真理子, 武市 拓也, 室 慶直, 秋山 真志

    日本皮膚科学会雑誌   Vol. 130 ( 9 ) page： 2090 - 2090   2020.8

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  23. 大腸癌切除後も病状が進行した抗PM/Scl抗体陽性皮膚筋炎の1例

    大野 由以佳, 桃原 真理子, 室 慶直, 秋山 真志, 山田 益丈

    日本皮膚科学会雑誌   Vol. 130 ( 7 ) page： 1672 - 1672   2020.6

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  24. 四肢に多発した腱黄色腫の1例

    帆苅 直弘, 桃原 真理子, 秋山 真志, 榊原 章浩

    日本皮膚科学会雑誌   Vol. 130 ( 2 ) page： 253 - 253   2020.2

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  25. 肺高血圧症を契機に診断され、免疫抑制療法が奏功した混合性結合組織病の1例

    原 真望, 桃原 真理子, 河野 通浩, 室 慶直, 秋山 真志, 中野 嘉久

    日本皮膚科学会雑誌   Vol. 129 ( 9 ) page： 1936 - 1936   2019.8

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  26. 左頸部の軟属腫様皮疹から診断した多臓器型Langerhans cell histiocytosis(LCH)の1例

    太田 早紀, 桃原 真理子, 河野 通浩, 秋山 真志, 北澤 宏展, 高橋 義行

    日本皮膚科学会雑誌   Vol. 129 ( 6 ) page： 1360 - 1360   2019.5

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  27. 当科における抗MJ抗体陽性の皮膚筋炎・多発筋炎の検討

    大河内 智子, 桃原 真理子, 室 慶直, 秋山 真志

    日本皮膚科学会雑誌   Vol. 129 ( 6 ) page： 1358 - 1358   2019.5

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  28. 【リウマチ性疾患診療に関連する皮膚病変の病態・診断・治療】皮膚筋炎および抗ARS抗体症候群の皮膚症状

    桃原 真理子, 室 慶直

    リウマチ科   Vol. 61 ( 3 ) page： 219 - 226   2019.3

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    Language：Japanese   Publisher：(有)科学評論社  

  29. 多発性筋炎・皮膚筋炎-4 皮膚筋炎/多発性筋炎群における抗Ro52抗体の臨床像

    桃原 真理子, 室 慶直

    日本リウマチ学会総会・学術集会プログラム・抄録集   Vol. 63回   page： 553 - 553   2019.3

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  30. TNFα阻害薬投与後に生じた抗MJ抗体陽性の炎症性筋疾患の1例

    大河内 智子, 桃原 真理子, 室 慶直, 河野 通浩, 秋山 真志, 原田 祐三子

    日本皮膚科学会雑誌   Vol. 129 ( 2 ) page： 193 - 193   2019.2

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  31. 急性膵炎に伴う皮下結節性脂肪壊死症の1例

    竹内 想, 桃原 真理子, 金田 友里恵, 河野 通浩, 秋山 真志

    日本皮膚科学会雑誌   Vol. 129 ( 2 ) page： 193 - 193   2019.2

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  32. 抗TIF1γ抗体陽性皮膚筋炎と合併癌の進行度は強く関連する

    桃原 真理子, 室 慶直, 満間 照之, 片山 雅夫, 簗場 広一, 奈良 瑞穂, 欠田 成人, 河野 通浩, 秋山 真志

    日本臨床免疫学会総会プログラム・抄録集   Vol. 46回   page： 126 - 126   2018.11

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  33. 抗TIF1γ抗体陽性皮膚筋炎と合併癌の進行度は強く関連する

    桃原 真理子, 室 慶直, 満間 照之, 片山 雅夫, 簗場 広一, 奈良 瑞穂, 欠田 成人, 河野 通浩, 秋山 真志

    日本臨床免疫学会総会プログラム・抄録集   Vol. 46回   page： 102 - 102   2018.11

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  34. IgG4陽性形質細胞の密な浸潤をみとめたアロポー稽留性肢端皮膚炎の一例

    桃原 真理子, 室 慶直, 武市 拓也, 中黒 匡人, 河野 通浩, 秋山 真志

    日本皮膚免疫アレルギー学会雑誌   Vol. 2 ( 1 ) page： 181 - 181   2018.10

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  35. IgG4陽性形質細胞の密な浸潤をみとめたアロポー稽留性肢端皮膚炎の一例

    桃原 真理子, 室 慶直, 武市 拓也, 中黒 匡人, 河野 通浩, 秋山 真志

    日本皮膚免疫アレルギー学会雑誌   Vol. 2 ( 1 ) page： 181 - 181   2018.10

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  36. 皮膚筋炎に伴う嚥下障害の予後

    桃原 真理子, 室 慶直, 満間 照之, 片山 雅夫, 簗場 広一, 奈良 瑞穂, 欠田 成人, 河野 通浩, 秋山 真志

    日本皮膚科学会雑誌   Vol. 128 ( 5 ) page： 1204 - 1204   2018.5

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  37. 免疫チェックポイント阻害薬に伴う膠原病発症と自己抗体産生に関する研究

    桃原 真理子, 室 義直

    大和証券ヘルス財団研究業績集   ( 41 ) page： 74 - 78   2018.3

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    自己免疫疾患(全身性エリテマトーデス、全身性強皮症、皮膚筋炎/多発筋炎等)に関連する自己抗体の産生動態および疾患の発症、免疫チェックポイント阻害薬を投与し抗腫瘍効果が得られた検体における腫瘍特異抗体産生の有無について検討した。1年の研究期間で得られた12症例では、約30%の4症例に抗甲状腺抗体を認めた。免疫チェックポイント阻害薬治療を受けた12例の患者より血清を採取した。部分奏効例(PR)が4例(M4、M5、M7、M11)、完全奏効例は1例(M8)のみであった。また、メラノーマ細胞、HaCaT細胞(ヒト不死化角化細胞)の培養細胞から抽出した細胞成分を用いて、患者検体12症例においてウエスタンブロットを行ったところ、検体M4、M8、M7においてHaCaT細胞、メラノーマ細胞の両方の細胞抽出物に対し強い反応を認めた。

  38. 皮膚筋炎に伴う嚥下障害の予後

    桃原 真理子, 室 慶直, 片山 雅夫, 奈良 瑞穂

    日本リウマチ学会総会・学術集会プログラム・抄録集   Vol. 62回   page： 665 - 665   2018.3

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  39. 【膠原病】皮膚筋炎

    桃原 真理子, 室 慶直, 秋山 真志

    現代医学   Vol. 65 ( 2 ) page： 17 - 20   2017.12

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    Language：Japanese   Publisher：(公社)愛知県医師会  

    近年、皮膚筋炎特異自己抗体の研究が進み、各抗体陽性例の臨床的特徴が明らかとなりつつある。本稿では、それらを紹介し、2015年に新たに刊行された多発性筋炎(以下PM)・皮膚筋炎(以下DM)治療ガイドラインと照らし合わせながら、治療におけるトピックを示す。(著者抄録)

  40. 【エリテマトーデスをきわめる-SLEエンサイクロペディア】(Part2)非特異的皮疹(case 15) 日光過敏

    桃原 真理子, 室 慶直, 秋山 真志

    Visual Dermatology   Vol. 16 ( 8 ) page： 776 - 777   2017.7

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    Language：Japanese   Publisher：(株)学研メディカル秀潤社  

  41. 【診断基準を満たさないとき、どうする?】(Part2)非典型例をどう考えるか(case10) 皮膚筋炎

    桃原 真理子, 室 慶直, 秋山 真志

    Visual Dermatology   Vol. 16 ( 7 ) page： 680 - 685   2017.6

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  42. スキルアップのためのQ&A 皮膚筋炎における筋生検のやり方を教えてください

    桃原 真理子, 室 慶直

    皮膚アレルギーフロンティア   Vol. 15 ( 1 ) page： 53 - 53   2017.3

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  43. 抗PM/Scl抗体陽性皮膚筋炎の3例はじめに

    桃原 真理子, 室 慶直, 滝 奉樹, 小川 靖, 杉浦 一充, 秋山 真志, 岡地 祥太郎, 曽根 淳

    中部リウマチ   Vol. 46 ( 2 ) page： 37 - 37   2017.3

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  44. 抗Ku抗体陽性であった若年発症の多発性筋炎/全身性強皮症の重複症候群の1例

    恒川 真央, 桃原 真理子, 河野 通浩, 室 慶直, 秋山 真志, 平山 哲之, 中西 浩隆, 勝野 雅央

    日本皮膚科学会雑誌   Vol. 127 ( 3 ) page： 484 - 484   2017.3

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  45. Sjoegren症候群および抗ARS抗体陽性多発性筋炎を併発したIgG4関連自己免疫性膵炎の1例

    吉川 真人, 室 慶直, 桃原 真理子, 河野 通浩, 秋山 真志, 伊藤 理

    日本皮膚科学会雑誌   Vol. 127 ( 2 ) page： 185 - 185   2017.2

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  46. 抗Mi-2抗体陽性で筋炎症状の乏しい皮膚筋炎の1例

    日高 友梨, 桃原 真理子, 室 慶直, 河野 通浩, 秋山 真志

    日本皮膚科学会雑誌   Vol. 126 ( 12 ) page： 2319 - 2319   2016.11

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  47. 腹痛およびショックバイタルで来院し、初診時、急性腹症が疑われたセロトニン症候群の1例

    西平 賀政, 桃原 真理子, 親富祖 勝己

    九州神経精神医学   Vol. 62 ( 2 ) page： 89 - 89   2016.8

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  48. 巨大石灰化を認めた抗U1-RNP抗体陽性強皮症の2例

    桃原 真理子, 室 慶直, 杉浦 一充, 松本 高明, 秋山 真志

    日本皮膚科学会雑誌   Vol. 126 ( 5 ) page： 941 - 941   2016.5

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  49. Long-term survival of a patient with paraneoplastic pemphigus due to follicular dendritic cell sarcoma

    Mariko Ogawa, Kazumitsu Sugiura, Yoshinao Muro, Takaaki Matsumoto, Hiroshi Koga, Takashi Hashimoto, Masashi Akiyama

    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY   Vol. 72 ( 5 ) page： AB121 - AB121   2015.5

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    Language：English   Publishing type：Research paper, summary (international conference)   Publisher：MOSBY-ELSEVIER  

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To the head of MISC.▲

KAKENHI (Grants-in-Aid for Scientific Research) 7

  1. 令和6年度日本皮膚科学会基礎医学研究費（資生堂寄付）

    2024.6 - 2025.6

    公益社団法人 日本皮膚科学会 

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    Authorship：Principal investigator 

  2. 表皮脂質異常・バリア障害・炎症、三位一体の魚鱗癬発症機序解明と現実的治療法の開拓

    Grant number：24K02470  2024.4 - 2027.3

    日本学術振興会  科学研究費助成事業  基盤研究(B)

    秋山 真志, 室 慶直, 棚橋 華奈, 滝 奉樹, 桃原 真理子

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    Authorship：Coinvestigator(s) 

    本研究では、多数の常染色体劣性先天性魚鱗癬(ARCI)患者と多系統の遺伝子改変魚鱗癬モデルマウス、皮膚炎症誘発マウスを対象に、表皮機能脂質の分析、角層バリア機能の評価、皮膚・血液でのシングルセル解析を含めた遺伝子発現プロファイリングを行う。そのデータから、表皮脂質異常、バリア障害、炎症の鍵となる分子、経路を明らかにする。さらに、表皮脂質異常・角層バリア障害・皮膚炎症の三位一体の病態の核となる分子、経路を特定し、それらを標的としたモデルマウス植皮治療実験により、ARCIの新規治療法を提案する。この新規治療法には、皮膚脂質異常、バリア障害を病因とする炎症性疾患の治療、予防への波及効果が期待される。

  3. 2023年度研究奨励金

    2024.4 - 2025.3

    公益財団法人 上原記念生命科学財団 

  4. Extracellular vesicle and autoantibody production

    Grant number：23K15265  2023.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

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    Authorship：Principal investigator 

    Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

  5. アレルゲン特異的IgG4の経皮的感作、脱感作における機能解析

    Grant number：19K17768  2021.11 - 2023.3

    日本学術振興会  科学研究費助成事業  若手研究

    桃原 真理子

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    Authorship：Principal investigator 

    Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）

    1.　尋常性魚鱗癬患者におけるアレルゲン特異的IgEとIgG4の検討：尋常性魚鱗癬のアトピー群、非アトピー群、健常群の血清を用いて、吸入抗原、食物抗原、皮膚表在菌などの皮膚感作抗原に対する各群での抗体の有無の傾向や抗体価の比較をELISAで行う。
    2.　抗炎症抗体としてのIgG4機能検討 ：アレルゲンと反応させた患者血清IgG4をM2マクロファージ（代替活性化マクロファージ）等と反応させ、活性化するかどうかを検証する。
    3.　抗原に吸着したIgG4のB細胞活性制御に関する検討：魚鱗癬患者より採取したB細胞に、アレルゲンに吸着したIgG4を反応させ、IgG4、IgEの産生量変化を見る。
    名古屋大学附属病院に採血、アンケート調査のための倫理申請を行い、2019年8月5日に前向き研究の許可を得た。アトピー性皮膚炎、先天性角化症患者さん、健常人へのアンケートおよび採血のご協力を得て、現在約70名ほどのデータと検体収集を行った。各アレルゲン（ヤケヒョウダニ、スギ、アスペルギルス、カンジタ、イヌ皮膚、黄色ブドウ球菌、マラセチア、アルテルナリア、卵白OVA）に対し、抗原を固相化したELISA法を用いて各患者およびコンロトール群の血清中のIgG4とIgE間の反応性を検体群ごとに比較した。
    現時点までの検討では、各検体のIgG4とIgEの反応性の傾向（IgG４、IｇEが抗吸着される頻度とパターン）が、各群で抗原ごとに大きく異なり、アレルゲンごとの感作、脱感作の経路や形式、あるいはIgG4の持つ役割が異なる可能性が強く示唆された。
    また、骨髄移植後のサンプルでは、寛解長期生存後もアレルギーの臨床症状を認めるものの、血清学的には全く反応を示していなかった例があり、別途検討を行う予定である。
    本研究は患者検体100と健常人検体30以上を予定しており、今後も引き続き検体の収集を平行して行っていく予定である。また、アレルゲン毎に異なる反応性が見られたため、その傾向をさらに検討するためにアレルゲンの種類を拡大、改良し、ELISAの方法を画一していく予定となっている。当実験ではIgEの反応性がやや弱い傾向にあり、今後改良の必要があると考えている。また、はっきりとした反応が見られた検体に対し、肥満細胞や形質細胞を用いた血球レベルの実験を追加していく予定である。

  6. 免疫チェックポイント阻害薬に伴う 膠原病発症と自己抗体産生に関する研究

    2017.4 - 2018.3

    大和証券ヘルス財団  第43回調査研究助成 

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    Authorship：Principal investigator 

  7. Analysis of autoimmune responses against DNA mismatch repair enzymes in dermatomyositis

    Grant number：26461656  2014.4 - 2018.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Muro Yoshinao, MOMOHARA MARIKO, YAMAMOTO ERI

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    Authorship：Other 

    DNA mismatch repair is an important life system, which is conserved from bacteria to human, and starts by mismatch recognition where seven kinds of enzymes are involved in human. We reported that patients with collagen diseases including inflammatory myopathy carry autoantibodies against four kinds of these enzymes. Further studies clarified that major targets of these antibodies are MLH1 and PMS1 and that some patients who had these antibodies also simultaneously carried other myositis-marker autoantibodies and other patients did not. We have found that commercially available substrates for indirect immunofluorescence tests were not suitable for the screening of autoantibodies against these enzymes and the suitable fixed cultured cells for the screening. Moreover, we have found the possibility that ultraviolet irradiation to cultured keratinocytes might influence the expression of these enzymes (autoantigens).

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To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲