Faculty Profiles - TAKEDA Ikuko

写真a

TAKEDA Ikuko

Organization

Graduate School of Medicine Program in Integrated Medicine Anatomy and Cell Biology Associate professor

Graduate School

Graduate School of Medicine

Undergraduate School

School of Medicine Department of Medicine

External link

Degree 1

医学（博士）（ 2014.1 広島大学）

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Research Interests 2

neuronal circuit
chronic pain

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Research History 6

Nagoya University Associate professor

2024.8
Nagoya University Department of Anatomy and Molecular Cell Biology, Gragudate School of Medicine Lecturer

2022.11 - 2024.7

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Country：Japan

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National Institutes of Natural Sciences, National Institute for Physiological Sciences Division of Multicellular Circuit Dynamics

2022.4

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Nagoya University Department of Anatomy and Molecular Cell Biology Graduate School of Medicine Assistant Professor

2021.9 - 2022.10

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National Institutes of Natural Sciences, National Institute for Physiological Sciences Division of Homeostatic Development

2020.5 - 2022.3

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Hiroshima University Assistant Professor

2015.4 - 2016.4

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Education 1

Hiroshima University

2009.4 - 2014.1

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Professional Memberships 6

The Physiological Society of Japan

2021.10
The Japan Neuroscience Society

2021.3
The Japanses Association of Anatomists

2021.3
Japanese sciety of neurology

2007.4
The Japan Stroke Society

2007.1
The Japan Society of Internal Medicine

2006.6

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Papers 27

Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour Reviewed International coauthorship International journal

Ikuko Takeda, Kohei Yoshihara, Dennis L. Cheung, Tomoko Kobayashi, Masakazu Agetsuma, Makoto Tsuda, Kei Eto, Schuichi Koizumi, Hiroaki Wake, Andrew J. Moorhouse, Junichi Nabekura

Nature Communications Vol. 13 ( 1 ) page： 4100 - 4100 2022.7

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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Chronic pain is a major public health problem that currently lacks effective treatment options. Here, a method that can modulate chronic pain-like behaviour induced by nerve injury in mice is described. By combining a transient nerve block to inhibit noxious afferent input from injured peripheral nerves, with concurrent activation of astrocytes in the somatosensory cortex (S1) by either low intensity transcranial direct current stimulation (tDCS) or via the chemogenetic DREADD system, we could reverse allodynia-like behaviour previously established by partial sciatic nerve ligation (PSL). Such activation of astrocytes initiated spine plasticity to reduce those synapses formed shortly after PSL. This reversal from allodynia-like behaviour persisted well beyond the active treatment period. Thus, our study demonstrates a robust and potentially translational approach for modulating pain, that capitalizes on the interplay between noxious afferents, sensitized central neuronal circuits, and astrocyte-activation induced synaptic plasticity.

DOI： 10.1038/s41467-022-31773-8

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Propagation of neuronal micronuclei regulates microglial characteristics

Sarasa Yano, Natsu Asami, Yusuke Kishi, Ikuko Takeda, Hikari Kubotani, Yuki Hattori, Ayako Kitazawa, Kanehiro Hayashi, Ken-ichiro Kubo, Mai Saeki, Chihiro Maeda, Chihiro Hiraki, Rin-ichiro Teruya, Takumi Taketomi, Kaito Akiyama, Tomomi Okajima-Takahashi, Ban Sato, Hiroaki Wake, Yukiko Gotoh, Kazunori Nakajima, Takeshi Ichinohe, Takeshi Nagata, Tomoki Chiba, Fuminori Tsuruta

Nature Neuroscience 2025.1

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Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1038/s41593-024-01863-5

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Other Link： https://www.nature.com/articles/s41593-024-01863-5
Neuromodulation with transcranial direct current stimulation contributes to motor function recovery via microglia in spinal cord injury. Reviewed International journal

Ryotaro Oishi, Ikuko Takeda, Yukihito Ode, Yuya Okada, Daisuke Kato, Hiroaki Nakashima, Shiro Imagama, Hiroaki Wake

Scientific reports Vol. 14 ( 1 ) page： 18031 - 18031 2024.8

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Spinal cord injury (SCI) is damage or trauma to the spinal cord, which often results in loss of function, sensation, or mobility below the injury site. Transcranial direct current stimulation (tDCS) is a non-invasive and affordable brain stimulation technique used to modulate neuronal circuits, which changes the morphology and activity of microglia in the cerebral cortex. However, whether similar morphological changes can be observed in the spinal cord remains unclear. Therefore, we evaluated neuronal population activity in layer 5 (L5) of M1 following SCI and investigated whether changes in the activities of L5 neurons affect microglia-axon interactions using C57BL/6J mice. We discovered that L5 of the primary motor cortex (corticospinal neurons) exhibited reduced synchronized activity after SCI that correlates with microglial morphology, which was recovered using tDCS. This indicates that tDCS promotes changes in the morphological properties and recovery of microglia after SCI. Combining immunotherapy with tDCS may be effective in treating SCI.

DOI： 10.1038/s41598-024-69127-7

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A dopamine D1-like receptor-specific agonist improves the survival of septic mice. Reviewed International journal

Koichi Tanaka, Mohammed E Choudhury, Satoshi Kikuchi, Ikuko Takeda, Kensuke Umakoshi, Noriyuki Miyaue, Kanta Mikami, Ayane Takenaga, Harumichi Yagi, Rintaro Shinabe, Hironori Matsumoto, Hajime Yano, Masahiro Nagai, Jun Takeba, Junya Tanaka

iScience Vol. 27 ( 4 ) page： 109587 - 109587 2024.4

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Language：English Publishing type：Research paper (scientific journal)

In this study, a murine sepsis model was developed using the cecum ligation and puncture (CLP) technique. The expression of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β) in the brain increased 6 h after CLP but decreased 24 h later when elevated endogenous dopamine levels in the brain were sustained. Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride reduced dopamine levels in the striatum and increased mortality in septic mice. Dopamine D1-like receptors were significantly expressed in the brain, but not in the lungs. Intraperitoneally administered SKF-81297 (SKF), a blood-brain barrier-permeable D1-like receptor agonist, prevented CLP-induced death of septic mice with ameliorated acute lung injury and cognitive dysfunction and suppressed TNF-α and IL-1β expression. The D1-like receptor antagonist SCH-23390 abolished the anti-inflammatory effects of SKF. These data suggest that D1-like receptor-mediated signals in the brain prevent CLP-induced inflammation in both the brain and the periphery.

DOI： 10.1016/j.isci.2024.109587

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Activity-dependent oligodendrocyte calcium dynamics and their changes in Alzheimer's disease. Reviewed International journal

Kenji Yoshida, Daisuke Kato, Shouta Sugio, Ikuko Takeda, Hiroaki Wake

Frontiers in cellular neuroscience Vol. 17 page： 1154196 - 1154196 2023.10

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Oligodendrocytes (OCs) form myelin around axons, which is dependent on neuronal activity. This activity-dependent myelination plays a crucial role in training and learning. Previous studies have suggested that neuronal activity regulates proliferation and differentiation of oligodendrocyte precursor cells (OPCs) and myelination. In addition, deficient activity-dependent myelination results in impaired motor learning. However, the functional response of OC responsible for neuronal activity and their pathological changes is not fully elucidated. In this research, we aimed to understand the activity-dependent OC responses and their different properties by observing OCs using in vivo two-photon microscopy. We clarified that the Ca2+ activity in OCs is neuronal activity dependent and differentially regulated by neurotransmitters such as glutamate or adenosine triphosphate (ATP). Furthermore, in 5-month-old mice models of Alzheimer's disease, a period before the appearance of behavioral abnormalities, the elevated Ca2+ responses in OCs are ATP dependent, suggesting that OCs receive ATP from damaged tissue. We anticipate that our research will help in determining the correct therapeutic strategy for neurodegenerative diseases beyond the synapse.

DOI： 10.3389/fncel.2023.1154196

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【ミクログリアがコードする情報の読み出しへの挑戦】ミクログリアによる脳機能制御と病態時の変化 Invited

和氣弘明, 橋本明香里, 加藤大輔, 竹田育子

日本薬理学雑誌 Vol. 158 ( 5 ) page： 359 - 361 2023.9

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Language：Japanese Publisher：(公社)日本薬理学会

ミクログリアは中枢神経系唯一の免疫細胞である.これまで発達期及び成熟期において神経幹細胞の細胞死に関与することで,能動的に神経細胞の数を制御することが明らかにされている.さらに近年の光学技術を用いて,生体イメージングが可能となり,ミクログリアのシナプスに対する機能が明らかとなってきた.ミクログリアはシナプス活動を定期的にモニターし,脳梗塞などの障害時には異常な活動を示すシナプスを取り除く働きがある.また発達期においては発達早期のシナプス形成時には,樹状突起に接触することで,未熟なシナプス形成に寄与し,さらに古典的補体カスケードシグナルを用いることで,活動の弱いシナプスを選択的に除去し,シナプス除去過程に関わる.さらにこれらの異常は発達期においては自閉症の発症に関与することが知られ,成熟期においてはアルツハイマー型認知症の発症に寄与することが知られている.これに加えて,ミクログリアは成熟期の学習過程のシナプスの可塑的変化にも寄与する.さらにシナプス活動を修飾することで,神経回路の活動変化にも関わることが知られている.このようなシナプスに対する機能に加えて,近年血液脳関門の透過性に関わることなども知られている.本章ではこれらの機能を総括し,論じたい.(著者抄録)

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The role of astrocytes in V2L neuronal remodeling following vision loss

Takeda, I; Hashimoto, A; Takei, I; Inoue, M; Kagamiuchi, M; Kato, D; Wake, H

JOURNAL OF NEUROCHEMISTRY Vol. 166 page： 127 - 128 2023.8

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Microglia enable cross-modal plasticity by removing inhibitory synapses. Reviewed International journal

Akari Hashimoto, Nanami Kawamura, Etsuko Tarusawa, Ikuko Takeda, Yuki Aoyama, Nobuhiko Ohno, Mio Inoue, Mai Kagamiuchi, Daisuke Kato, Mami Matsumoto, Yoshihiro Hasegawa, Junichi Nabekura, Anne Schaefer, Andrew J Moorhouse, Takeshi Yagi, Hiroaki Wake

Cell reports Vol. 42 ( 5 ) page： 112383 - 112383 2023.5

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Cross-modal plasticity is the repurposing of brain regions associated with deprived sensory inputs to improve the capacity of other sensory modalities. The functional mechanisms of cross-modal plasticity can indicate how the brain recovers from various forms of injury and how different sensory modalities are integrated. Here, we demonstrate that rewiring of the microglia-mediated local circuit synapse is crucial for cross-modal plasticity induced by visual deprivation (monocular deprivation [MD]). MD relieves the usual inhibition of functional connectivity between the somatosensory cortex and secondary lateral visual cortex (V2L). This results in enhanced excitatory responses in V2L neurons during whisker stimulation and a greater capacity for vibrissae sensory discrimination. The enhanced cross-modal response is mediated by selective removal of inhibitory synapse terminals on pyramidal neurons by the microglia in the V2L via matrix metalloproteinase 9 signaling. Our results provide insights into how cortical circuits integrate different inputs to functionally compensate for neuronal damage.

DOI： 10.1016/j.celrep.2023.112383

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特集慢性疼痛慢性疼痛とシナプス再編-グリア細胞制御による治療法を目指して

鍋倉淳一, 竹田育子

BRAIN and NERVE Vol. 75 ( 3 ) page： 207 - 216 2023.3

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Publisher：株式会社医学書院

DOI： 10.11477/mf.1416202310

CiNii Research
[Microglial regulation of brain function and pathological changes].

Wake H, Hashimoto A, Kato D, Takeda I

Nihon yakurigaku zasshi. Folia pharmacologica Japonica Vol. 158 ( 5 ) page： 359 - 361 2023

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Language：Japanese

DOI： 10.1254/fpj.23010

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【グリアデコード:新領域の発展性】ミクログリアとシナプス機能

和氣弘明, 橋本明香里, 竹田育子, 加藤大輔

Medical Science Digest Vol. 48 ( 14 ) page： 678 - 680 2022.12

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Language：Japanese Publisher：(株)ニュー・サイエンス社

神経細胞間はシナプスと呼ばれる構造で連結されている。このシナプスはヒトの記憶や学習を司る構造物として,重要な知見が明らかにされている。本章では脳唯一の免疫細胞であるミクログリアのシナプス修飾に対する知見を紹介したい。(著者抄録)

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Overexpression of neuronal K+-Cl- co-transporter enhances dendritic spine plasticity and motor learning. Reviewed

Kayo Nakamura, Andrew John Moorhouse, Dennis Lawrence Cheung, Kei Eto, Ikuko Takeda, Paul Wiers Rozenbroek, Junichi Nabekura

The journal of physiological sciences : JPS Vol. 69 ( 3 ) page： 453 - 463 2019.5

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The neuronal K+-Cl- cotransporter KCC2 maintains a low intracellular Cl- concentration and facilitates hyperpolarizing GABAA receptor responses. KCC2 also plays a separate role in stabilizing and enhancing dendritic spines in the developing nervous system. Using a conditional transgenic mouse strategy, we examined whether overexpression of KCC2 enhances dendritic spines in the adult nervous system and characterized the effects on spine dynamics in the motor cortex in vivo during rotarod training. Mice overexpressing KCC2 showed significantly increased spine density in the apical dendrites of layer V pyramidal neurons, measured in vivo using two-photon imaging. During modest accelerated rotarod training, mice overexpressing KCC2 displayed enhanced spine formation rates, greater balancing skill at higher rotarod speeds and a faster rate of learning in this ability. Our results demonstrate that KCC2 enhances spine density and dynamics in the adult nervous system and suggest that KCC2 may play a role in experience-dependent synaptic plasticity.

DOI： 10.1007/s12576-018-00654-5

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Cortical astrocytes prime the induction of spine plasticity and mirror image pain. Reviewed International journal

Tatsuya Ishikawa, Kei Eto, Sun Kwang Kim, Hiroaki Wake, Ikuko Takeda, Hiroshi Horiuchi, Andrew J Moorhouse, Hitoshi Ishibashi, Junichi Nabekura

Pain Vol. 159 ( 8 ) page： 1592 - 1606 2018.8

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Peripheral nerve injury causes maladaptive plasticity in the central nervous system and induces chronic pain. In addition to the injured limb, abnormal pain sensation can appear in the limb contralateral to the injury, called mirror image pain. Because synaptic remodeling in the primary somatosensory cortex (S1) has critical roles in the induction of chronic pain, cortical reorganization in the S1 ipsilateral to the injured limb may also accompany mirror image pain. To elucidate this, we conducted in vivo 2-photon calcium imaging of neuron and astrocyte activity in the ipsilateral S1 after a peripheral nerve injury. We found that cross-callosal inputs enhanced the activity of both S1 astrocytes and inhibitory neurons, whereas activity of excitatory neurons decreased. When local inhibitory circuits were blocked, astrocyte-dependent spine plasticity and allodynia were revealed. Thus, we propose that cortical astrocytes prime the induction of spine plasticity and mirror image pain after peripheral nerve injury. Moreover, this result suggests that cortical synaptic rewiring could be sufficient to cause allodynia on the uninjured periphery.

DOI： 10.1097/j.pain.0000000000001248

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The roles of cortical astrocytes in chronic pain and other brain pathologies. Reviewed International journal

Kei Eto, Sun Kwang Kim, Ikuko Takeda, Junichi Nabekura

Neuroscience research Vol. 126 page： 3 - 8 2018.1

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Astrocytes are the most abundant cell type in the brain. Several decades ago, they were considered to be only support cells in the central nervous system. Recent studies using advanced technologies have clarified that astrocytes play more active roles in regulating neuronal function and remodeling synaptic structures by releasing molecules called gliotransmitters. In addition to various physiological functions, astrocytes are activated under disease conditions, such as chronic pain, releasing molecules that in turn cause reorganization of the central nervous system microstructure and disrupt behavior in pathological conditions. In the present review, we summarize cortical astrocyte function in chronic pain and other neurological disorders and discuss the role of astrocytes in brain pathologies.

DOI： 10.1016/j.neures.2017.08.009

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Neurological Complications in Eosinophilic Granulomatosis with Polyangiitis (EGPA): The Roles of History and Physical Examinations in the Diagnosis of EGPA. Reviewed

Hiroshi Oiwa, Sho Mokuda, Tomoyasu Matsubara, Masamoto Funaki, Ikuko Takeda, Takemori Yamawaki, Kazuhiko Kumagai, Eiji Sugiyama

Internal medicine (Tokyo, Japan) Vol. 56 ( 22 ) page： 3003 - 3008 2017.11

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Objective To investigate the clinical symptoms, the physical and neurological findings, and the clinical course of neurological complications in eosinophilic granulomatosis with polyangiitis (EGPA). Methods A retrospective chart review of EGPA cases managed by two referral hospitals was performed, with a focus on the neurological findings. The study analyzed the symptoms at the onset of EGPA and investigated their chronological relationship. The patient delay (the delay between the onset of symptoms and the initial consultation), and the physician delay (the delay from consultation to the initiation of therapy) were determined and compared. The involved nerves were identified thorough a neurological examination. The cases with central nervous system (CNS) involvement were described. Results The average duration of symptoms prior to the initiating of therapy for sensory disturbances, motor deficits, rash, edema, and fever was 23, 5, 21, 18, and 24 days, respectively. Among the EGPA-specific symptoms, sensory disturbance was often the first symptom (63%), and was usually followed by the appearance of rash within four days (63%). The average physician delay (32.9±38.3 days) was significantly longer than the average patient delay (7.9±7.8 days; p=0.010). Reduced touch sensation in the superficial peroneal area, and weakness of dorsal flexion of the first toe secondary to deep peroneal nerve involvement, were highly sensitive for identifying the presence of peripheral nerve involvement in our series of patients with EGPA. Two cases, with CNS involvement, had multiple skin lesions over their hands and feet (Janeway lesions). Conclusion Japanese physicians are not always familiar with EGPA. It is important for us to consider this disease, when an asthmatic patient complains about the new onset of an abnormal sensation in the distal lower extremities, which is followed several days later by rash.

DOI： 10.2169/internalmedicine.8457-16

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A case of chronic inflammatory demyelinating polyradiculoneuropathy after treatment with pegylated interferon ?-2a in a patient with chronic hepatitis B virus infection Reviewed

Hiroyuki Naito, Ikuko Takeda, Akiko Segawa, Masataka Tsuge, Hirofumi Maruyama, Masayasu Matsumoto

Clinical neurology Vol. 56 ( 10 ) 2016.9

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CD34+/CD144+ Circulating Endothelial Cells as an Indicator of Carotid Atherosclerosis Reviewed

Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association Vol. 24 ( 3 ) page： 583 - 590 2014.12

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DOI： 10.1016/j.jstrokecerebrovasdis.2014.10.001
Safety Evaluation of Substituting Clopidogrel for Ticlopidine in Japanese Patients with Ischemic Stroke—Hiroshima Ticlopidine, Clopidogrel Safe Exchange Trial Reviewed

Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association Vol. 23 ( 6 ) 2014.7

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Isolated Unilateral Hypoglossal Nerve Paralysis Caused by Internal Carotid Artery Dissection Reviewed

Journal of stroke and cerebrovascular diseases: the official journal of National Stroke Association Vol. 23 ( 8 ) 2014.7

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Fiber Type-Specific Expression of Low-Density Lipoprotein Receptor-Related Protein 6 in Human Skeletal Muscles Reviewed

Pathobiology Vol. 81 ( 2 ) page： 94 - 99 2014.1

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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Autosomal recessive Andersen–Tawil syndrome with a novel mutation L94P in Kir2.1 Invited Reviewed

Neurology and Clinical Neuroscience 2013.7

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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)
Cancer-associated ischemic stroke is associated with elevated D-dimer and fibrin degradation product levels in acute ischemic stroke with advanced cancer Invited Reviewed

Geriatrics & Gerontology International 2012.1

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Clinical characteristics of ischemic stroke in elderly patients with cancer Invited Reviewed

Japanese Journal of Geriatrics 2011.1

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Two Cases of Cerebral Embolism Caused by Apical Thrombi in Midventricular Obstructive Cardiomyopathy Invited Reviewed

Internal Medicine 2011.1

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Efficacy of the Free Radical Scavenger, Edaravone, for Motor Palsy of Acute Lacunar Infarction Invited Reviewed

Internal Medicine 2009.1

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Two Populations of microglial cells isolated from rat primary mixed glial cultures Reviewed

Journal of Neuroscience Research 2003.7

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Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors Reviewed

Neuropharmacology 2002.11

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Books 1

糖尿病診療ガイドライン

竹田育子，大槻俊輔，松本昌泰（ Role： Joint author , 糖尿病における脳血管障害のリスク）

南山堂 2011.2 （ ISBN:978-4-525-23821-6 ）

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Total pages：422

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MISC 17

Psychiatric disorders and neuroinflammation: Approaching the multidirectional function of microglia

竹田育子, 和氣弘明

臨床精神医学 Vol. 53 ( 4 ) 2024

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J-GLOBAL

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Holographic measurement and manipulation of multicellular circuit dynamics

和氣弘明, 和氣弘明, 加藤大輔, 竹田育子, 竹田育子

実験医学 Vol. 42 ( 7 ) 2024

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J-GLOBAL

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一次体性感覚野アストロサイトの活動制御による痛み関連行動の治療 Invited

竹田育子

Vol. 2 2023.4

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Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (other)
【慢性疼痛】慢性疼痛とシナプス再編グリア細胞制御による治療法を目指して

鍋倉淳一, 竹田育子

BRAIN and NERVE: 神経研究の進歩 Vol. 75 ( 3 ) page： 0207 - 0216 2023.3

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Language：Japanese Publisher：(株)医学書院

＜文献概要＞慢性疼痛は,痛覚過敏など体性感覚ばかりでなく,不安など多くの脳機能の異常を伴う。その病態メカニズムとして関連する脳部位の神経回路の長期変化が挙げられる。本論では,痛覚過敏を引き起こす病的回路構築へのグリア細胞の関与,および,異常感覚に関連する回路の可塑性を操作し,病的回路の修復と異常痛覚の除去の試みと臨床応用への期待について解説する。

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体の「痛い」を脳から治す ―痛みに関わる神経回路を標的とした疼痛の新たな治療戦略― Invited

竹田育子

神経科学トピックス 2023.2

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ミクログリアによる脳機能制御と病態時の変化 Invited

和氣弘明、橋本明香里、加藤大輔、竹田育子

日本薬理学雑誌 Vol. 158 ( 5 ) 2023

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Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)

DOI： https://doi.org/10.1254/fpj.23010
ミクログリアとシナプス機能

和氣弘明、橋本明香里、竹田育子、加藤大輔

2022.11
ミクログリアの生理機能と病態 Invited

渋下碧、竹田育子、和氣弘明

炎症と免疫 Vol. 30 ( 3 ) 2022.4

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医学用語解説ミクログリアの生理機能と病態

渋下碧, 竹田育子, 和氣弘明

炎症と免疫 Vol. 30 ( 3 ) page： 280 - 285 2022.4

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Language：Japanese Publisher：(株)先端医学社

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【脳神経回路と高次脳機能スクラップ&ビルドによる心の発達と脳疾患の謎を解く】(第3章)脳発達・再編と病気・障害発達・病態における神経回路再編成

江藤圭, 竹田育子, 鍋倉淳一

実験医学 Vol. 36 ( 12 ) page： 2087 - 2094 2018.8

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Language：Japanese Publisher：(株)羊土社

感覚や感情は脳で多くの神経細胞がシナプスを介して情報のやりとりをすることで生じる。このシナプスは常に一定ではなくさまざまな内外環境変化に応じて劇的に変化する。発達期には、シナプスが一度過剰に形成された後、不要なシナプスが刈り込まれることで、適切な機能を行うための脳神経回路が形成される。一方、脳梗塞や慢性疼痛などのさまざまな病態においてもシナプス構造の劇的な変化が起きる。本稿では、二光子顕微鏡を用いた生体イメージングにより明らかにされた発達期、病態時の神経回路再編成に関する知見を中心に紹介する。(著者抄録)

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【ペインリハビリテーションの新潮流・新戦略】ペインリハビリテーションの基礎理論大脳皮質体性感覚野における神経回路の再構築慢性疼痛への関与

竹田育子, 江藤圭, 鍋倉淳一

ペインクリニック Vol. 39 ( 別冊春 ) page： S35 - S41 2018.4

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Language：Japanese Publisher：(株)シービーアール

慢性疼痛において、末梢神経傷害後の急性期には、大脳皮質一次体性感覚野では神経活動亢進している。それに加えてアストロサイトの活動が亢進しており、シナプス形成分子を分泌することにより新たなシナプス形成を促進し、神経細胞のシナプスの形成・消失が亢進、痛覚回路を構築する。(著者抄録)

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The roles of cortical astrocytes in chronic pain and other brain pathologies. Invited

Eto K, Kim SK, Takeda I, Nabekura J

Neuroscience Research Vol. 126 page： 3 - 8 2018

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Authorship：Last author Language：English
発達・病態における神経回路再編成 Invited

江藤圭，竹田育子，鍋倉淳一

実験医学 Vol. 36 page： 125 - 132 2018

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Authorship：Last author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
大脳皮質体性感覚野における神経回路の再構築 Invited

竹田育子，江藤圭，鍋倉淳一

ペインクリニック Vol. 39 page： 35 - 41 2018

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Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (scientific journal)
突発性ミオグロビン尿で発症した脂質代謝異常症の一例 Reviewed

増田沙季, 倉重毅志, 同道頼子, 竹田育子, 上野弘貴, 西野一三, 丸山博文

臨床神経学 Vol. 57 ( 5 ) page： 251 - 251 2017.5

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Language：Japanese Publisher：(一社)日本神経学会

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平衡機能障害・運動失調 Invited

竹田育子，山脇健盛

medicina Vol. 49 ( 4 ) page： 614 - 616 2012

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Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)
麻痺／しびれ Invited

竹田育子，山脇健盛

診断と治療 Vol. 99 ( 1 ) page： 31 - 35 2011

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Authorship：Lead author Language：Japanese Publishing type：Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)

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To the head of MISC.▲

Presentations 27

痛みに関わるニューロングリア連関から見た心・知・体ネットワーク Invited

竹田育子

女性研究者によるシンポジウム(APPW2025) 2025.3.16

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Event date： 2025.3

Venue：幕張メッセ
The role of astrocyte in V2L neuronal remodeling following vision loss International conference

Ikuko Takeda

ASPIRE-GLIA Symposium 2024.9.17

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Event date： 2024.9

Language：English Presentation type：Oral presentation (general)

Country：Switzerland
アストロサイトの活動制御による慢性疼痛治療

竹田育子

第129回日本解剖学会総会・全国学術集会 2024.3.23

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Event date： 2024.3

Language：Japanese Presentation type：Symposium, workshop panel (public)

Venue：沖縄 Country：Japan
視覚喪失がもたらすアストロサイトによる高次視覚野V2Lの神経回路編成

竹田　育子

第10回　先進イメージング医学研究会 2024.3.1

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Event date： 2024.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：兵庫県
色視覚入力による疼痛治療の開発

竹田　育子

JST-CREST「マルチセンシング」領域会議 2024.1.18

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Event date： 2024.1

Language：Japanese Presentation type：Oral presentation (general)

Venue：京都　知恩院和順会館
The role of astrocyte in V2L neuronal remodeling following vision loss

Ikuko Takeda, Mio Inoue, Izumo Takei, Akari Hashimoto, Mai Kagamiuchi, Yuki Aoyama, Daisuke Kato, Hiroaki Wake

2023.12.26

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Event date： 2023.12

Language：Japanese Presentation type：Poster presentation
The role of astrocytes in V2L neuronal remodeling following vision loss

Ikuko Takeda, Akari Hashimoto, Izumo Takei, Mio Inoue, Hiroaki Wake

Neuroscience2023 2023.11.11

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Event date： 2023.11

Language：English Presentation type：Poster presentation

Country：United States
Reactivation of astrocytes reverses pain-like behaviour International conference

FAOPS 2023 2023.11.2

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Event date： 2023.10 - 2023.11

Language：English Presentation type：Symposium, workshop panel (public)
The role of astrocytes following vision loss

Ikuko Takeda, Akari Hashimoto, Izumo Takei, Mio Inoue, Mai Kagamiuchi, Daisuke Kato, Hiroaki Wake

50th Naito Conference 2023.10.11

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Event date： 2023.10

Language：English Presentation type：Poster presentation
The role of astrocytes in V2L neuronal remodeling following vision loss International conference

Ikuko Takeda

Young Glia Meeting 2023.10.4

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Event date： 2023.10

Language：English Presentation type：Oral presentation (general)

Venue：Victoria
The role of astrocytes following vision loss

Ikuko Takeda

2023.9.19

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Event date： 2023.9

Language：Japanese
The role of astrocytes in V2L neuronal remodeling following vision loss International conference

Ikuko Takeda

ISN-ESN meeting 2023.8.12

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Event date： 2023.8

Language：English Presentation type：Poster presentation

Venue：Porto Country：Portugal
アストロサイトが関与する高次視覚野感覚統合機序

竹田育子

第6回グリアデコーディング領域会議 2023.7.17 グリアデコード

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Event date： 2023.7

Language：English Presentation type：Poster presentation

Country：Japan
The role of glial cells in cross-modal plasticity

2023.7.7

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Event date： 2023.7

Language：English Presentation type：Symposium, workshop panel (public)

Country：Japan
Astrocyte-mediated neuronal circuit remodeling in higher visual cortex induced by sensory deprivation International conference

2023.4.27 CSH Asia

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Event date： 2023.4

Language：English Presentation type：Poster presentation

Country：Japan
Astrocyte-mediated neuronal circuit remodeling in higher visual cortex induced by sensory deprivation

2023.3.15

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Event date： 2023.3

Language：English Presentation type：Poster presentation

Country：Japan
アストロサイトが誘導する神経回路再編成 Invited

竹田育子

次世代脳 2022.12.16 次世代脳プロジェクト

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Event date： 2022.12

Language：Japanese Presentation type：Public lecture, seminar, tutorial, course, or other speech

Venue：オンライン Country：Japan
ミクログリアによる異種感覚の可塑性

竹田育子

学術変革A iPlasticity 夏の領域会議 2022.8.3 学術変革A iPlasticity

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Event date： 2022.8

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
The alteration of astrocytes in cross-modal plasticity

Ikuko Takeda

Neuro2022 2022.7.1

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Event date： 2022.6 - 2022.7

Language：English Presentation type：Poster presentation

Country：Japan
一次体性感覚野のアストロサイトによる慢性疼痛への治療的アプローチ

竹田　育子、Dennis L. Chung、和氣　弘明、鍋倉　淳一

第127回日本解剖学会総会・全国学術集会 2022.3.28

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Event date： 2022.3

Language：Japanese Presentation type：Poster presentation
Modulating astrocytes activation reorganizes noxious circuits in chronic pain

Ikuko Takeda, Dennis L. Cheung, Hiroaki Wake, Junichi Nabekura

2022.3.17

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Event date： 2022.3

Language：English Presentation type：Poster presentation
Modulating astrocyte activity reverse allodynia in chronic pain

Ikuko Takeda

2022.1.18

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Event date： 2022.1

Language：English Presentation type：Oral presentation (general)
ミクログリアによる異種感覚の可塑性構築機序

竹田　育子

学術変革A臨界期生物学2021年領域班会議 2022.1.14

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Event date： 2022.1

Language：Japanese Presentation type：Oral presentation (general)
Modulating astrocyte activation reorganizes noxious circuits in chronic pain

Ikuko Takeda, Hiroaki Wake, Junichi Nabekura

2021.12.17

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Event date： 2021.12
Activated astrocytes as a therapeutic approach adjust noxious circuits in chronic pain International coauthorship

Ikuko Takeda, Dennis L. Cheung, Junichi Nabekura

2021.7.28

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Event date： 2021.7

Language：English Presentation type：Poster presentation
Astrocyte rehabilitate noxious circuits

Ikuko Takeda

the 98th Annual Meeting of The Physiological Society of Japan, the 126th Annual Meeting of The Japanese Association of Anatomists 2021.3.29

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Event date： 2021.3

Language：English Presentation type：Symposium, workshop panel (public)
Reactivation of astrocytes can reverse chronic pain

Ikuko Takeda

The 10th NIPS-PRI-BRINU Joint Symposium 2021.3.12

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Event date： 2021.3

Language：English Presentation type：Poster presentation

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To the head of Presentations.▲

Research Project for Joint Research, Competitive Funding, etc. 1

色から迫る慢性疼痛治療と神経回路基盤編成

Grant number：2600007301 2022.4 - 2023.3

堀科学芸術振興財団研究費助成

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Authorship：Principal investigator Grant type：Competitive

Grant amount：\1000000

To the head of Research Project for Joint Research, Competitive Funding, etc..▲

KAKENHI (Grants-in-Aid for Scientific Research) 6

ミクログリアによる異種感覚の可塑性構築機序

Grant number：21H05688 2021.9 - 2023.3

科学研究費助成事業学術変革領域研究(A)

竹田育子

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Authorship：Principal investigator

Grant amount：\7800000 （ Direct Cost: \6000000 、 Indirect Cost：\1800000 ）
Cheromotherapy relieves pain by neural circuit organisation

Grant number：23K06825 2023.4 - 2026.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Principal investigator

Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）

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Development of pain treatment using color

2023.4 - 2024.3

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感覚モダリティ理解のためのミクログリア・シナプス接触の多角的解析

Grant number：20KK0170 2020.10 - 2024.3

国際共同研究加速基金(国際共同研究強化(B))

和氣弘明

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Authorship：Coinvestigator(s)

本国際研究では中枢神経系唯一の免疫細胞であるミクログリアに着目し、ミクログリアがシナプスの構造的・機能的可塑性を修飾する背景を踏まえ、多角的階層的な技術を相互補完することによって、ミクログリアのシナプスに対する時間的(発達・成熟)および空間(脳領域)特異的な生理機能を明らかにする。さらにこれを異種感覚の可塑的変化のメカニズムに繋げ、そこから精神病態を考察する。
S1 astrocytes are therapeutic target for chronic pain

Grant number：20K16510 2020.4 - 2022.3

Grant-in-Aid for Early-Career Scientists

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Authorship：Principal investigator

Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）
Astrocytic modulation of tauopathy

Grant number：17K16133 2017.4 - 2019.3

Takeda Ikuko

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Authorship：Principal investigator

Grant amount：\3640000 （ Direct Cost: \2800000 、 Indirect Cost：\840000 ）

This study is to find a new tool to specifically activate astrocytes for a novel therapeutic target of tauopathy. To induce astrocyte activation, I used hM3Dq(Gq)-DREADD under GFAP promter. Astrocytes exprssed hM3Dq(Gq)-DREADD showed the increase of long-term Ca2+ transients via G protein signaling following CNO intraperitoneal injection. Activated astrocytes increased spine turnover rates in long-term spine imaging during CNO injection, possibly rewiring neural circuits.

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To the head of KAKENHI (Grants-in-Aid for Scientific Research).▲

Teaching Experience (On-campus) 15

肉眼解剖

2024
ベーシックトレーニングコース

2024
基礎セミナーＡ

2024
基礎医学体験実習

2024
神経解剖

2024
基礎医学体験実習

2023
解剖学実習

2023

　詳細を見る

頭頸部解剖
基礎セミナーＡ

2023
骨解剖実習

2023
神経解剖実習

2022
解剖学実習

2022
骨解剖実習

2022
基礎セミナーＡ

2022
Neuroanatomy

2022
基礎生物学II

2021

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To the head of Teaching Experience (On-campus).▲