Updated on 2024/03/18

写真a

 
NAKAYAMA Tomoya
 
Organization
Institute for Advanced Research Designated assistant professor
Graduate School of Bioagricultural Sciences Designated assistant professor
Title
Designated assistant professor
External link

Degree 1

  1. 博士(農学) ( 2019.3   名古屋大学 ) 

Research Interests 6

  1. 温度適応

  2. 季節適応

  3. 動物生理学

  4. 分子生物学

  5. 光周性

  6. メダカ

Research Areas 5

  1. Life Science / Aquatic life science

  2. Life Science / Laboratory animal science

  3. Life Science / Animal physiological chemistry, physiology and behavioral biology

  4. Life Science / Animal physiological chemistry, physiology and behavioral biology

  5. Life Science / Molecular biology

Research History 4

  1. Nagoya University   Nagoya University

    2020.4

  2. 日本学術振興会 特別研究員 PD

    2019.4 - 2020.3

  3. 日本学術振興会 特別研究員 DC2

    2018.4 - 2019.3

  4. 自然科学研究機構 基礎生物学研究所 技術支援員

    2016.1 - 2016.3

Education 2

  1. National Institutes of Natural Sciences

    2016.4 - 2019.3

  2. 名古屋大学 大学院生命農学研究科 博士課程後期課程(吉村崇教授)

    2016.4 - 2019.3

Professional Memberships 4

  1. 日本水産学会

    2021

  2. 日本生態学会

    2019

  3. 日本動物学会

    2017

  4. 日本時間生物学会

    2016

Committee Memberships 2

  1.   生物リズム若手研究者の集い, 世話人  

    2024.1   

  2.   日本時間生物学会, 評議員  

    2022.8   

Awards 2

  1. 日本時間生物学会優秀ポスター賞

    2019.10   日本時間生物学会   長鎖ノンコーディングRNAであるLDAIRは自己防衛行動の季節変化を制御する

    中山 友哉

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    Award type:Award from Japanese society, conference, symposium, etc. 

    第26回日本時間生物学会学術大会

  2. ITbM Research Award

    2019.1   Long-term live imaging of glutathione in cells and tissues by phospha-rhodamine based fluorescent probes

    L. Wang, S. Takeda, T. Nakayama, Y. Nakane, M. Taki

 

Papers 12

  1. A transcriptional program underlying the circannual rhythms of gonadal development in medaka Reviewed International journal

    Tomoya Nakayama, Miki Tanikawa, Yuki Okushi, Thoma Itoh, Tsuyoshi Shimmura, Michiyo Maruyama, Taiki Yamaguchi, Akiko Matsumiya, Ai Shinomiya, Ying-Jey Guh, Junfeng Chen, Kiyoshi Naruse, Hiroshi Kudoh, Yohei Kondo, Honda Naoki, Kazuhiro Aoki, Atsushi J. Nagano, Takashi Yoshimura

    Proceedings of the National Academy of Sciences   Vol. 120 ( 52 )   2023.12

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Proceedings of the National Academy of Sciences  

    To cope with seasonal environmental changes, organisms have evolved approximately 1-y endogenous circannual clocks. These circannual clocks regulate various physiological properties and behaviors such as reproduction, hibernation, migration, and molting, thus providing organisms with adaptive advantages. Although several hypotheses have been proposed, the genes that regulate circannual rhythms and the underlying mechanisms controlling long-term circannual clocks remain unknown in any organism. Here, we show a transcriptional program underlying the circannual clock in medaka fish ( Oryzias latipes ). We monitored the seasonal reproductive rhythms of medaka kept under natural outdoor conditions for 2 y. Linear regression analysis suggested that seasonal changes in reproductive activity were predominantly determined by an endogenous program. Medaka hypothalamic and pituitary transcriptomes were obtained monthly over 2 y and daily on all equinoxes and solstices. Analysis identified 3,341 seasonally oscillating genes and 1,381 daily oscillating genes. We then examined the existence of circannual rhythms in medaka via maintaining them under constant photoperiodic conditions. Medaka exhibited approximately 6-mo free-running circannual rhythms under constant conditions, and monthly transcriptomes under constant conditions identified 518 circannual genes. Gene ontology analysis of circannual genes highlighted the enrichment of genes related to cell proliferation and differentiation. Altogether, our findings support the “histogenesis hypothesis” that postulates the involvement of tissue remodeling in circannual time-keeping.

    DOI: 10.1073/pnas.2313514120

  2. Orphan nuclear receptor nr4a1 regulates winter depression-like behavior in medaka. Reviewed International journal

    Tomoya Nakayama, Fuka Hirano, Yuki Okushi, Kousuke Matsuura, Miki Ohashi, Akiko Matsumiya, Takashi Yoshimura

    Neuroscience letters     page: 137469 - 137469   2023.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    About 10% of the population suffers from depression in winter at high latitude. Although it has become a serious public health issue, its underlying mechanism remains unknown and new treatments and therapies are required. As an adaptive strategy, many animals also exhibit depression-like behavior in winter. Previously, it has been reported that celastrol, a traditional Chinese medicine, can rescue winter depression-like behavior in medaka, an excellent model of winter depression. Nuclear receptor subfamily 4 group A member 1 (nr4a1, also known as nur77) is a known target of celastrol, and the signaling pathway of nr4a1 was suggested to be inactive in medaka brain during winter, implying the association of nr4a1 and winter depression-like behavior. However, the direct evidence for its involvement in winter depression-like behavior remains unclear. The present study found that nr4a1 was suppressed in the medaka brain under winter conditions. Cytosporone B, nr4a1 chemical activator, reversed winter depression-like behavior under winter conditions. Additionally, nr4a1 mutant fish generated by CRISPR/Cas9 system showed decreased sociability under summer conditions. Therefore, our results demonstrate that the seasonal regulation of nr4a1 regulates winter depression-like behavior and offers potential therapeutic target.

    DOI: 10.1016/j.neulet.2023.137469

    PubMed

  3. Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior. Reviewed International journal

    Tomoya Nakayama, Kousuke Okimura, Jiachen Shen, Ying-Jey Guh, T Katherine Tamai, Akiko Shimada, Souta Minou, Yuki Okushi, Tsuyoshi Shimmura, Yuko Furukawa, Naoya Kadofusa, Ayato Sato, Toshiya Nishimura, Minoru Tanaka, Kei Nakayama, Nobuyuki Shiina, Naoyuki Yamamoto, Andrew S Loudon, Taeko Nishiwaki-Ohkawa, Ai Shinomiya, Toshitaka Nabeshima, Yusuke Nakane, Takashi Yoshimura

    Proceedings of the National Academy of Sciences of the United States of America   Vol. 117 ( 17 ) page: 9594 - 9603   2020.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Seasonal changes in the environment lead to depression-like behaviors in humans and animals. The underlying mechanisms, however, are unknown. We observed decreased sociability and increased anxiety-like behavior in medaka fish exposed to winter-like conditions. Whole brain metabolomic analysis revealed seasonal changes in 68 metabolites, including neurotransmitters and antioxidants associated with depression. Transcriptome analysis identified 3,306 differentially expressed transcripts, including inflammatory markers, melanopsins, and circadian clock genes. Further analyses revealed seasonal changes in multiple signaling pathways implicated in depression, including the nuclear factor erythroid-derived 2-like 2 (NRF2) antioxidant pathway. A broad-spectrum chemical screen revealed that celastrol (a traditional Chinese medicine) uniquely reversed winter behavior. NRF2 is a celastrol target expressed in the habenula (HB), known to play a critical role in the pathophysiology of depression. Another NRF2 chemical activator phenocopied these effects, and an NRF2 mutant showed decreased sociability. Our study provides important insights into winter depression and offers potential therapeutic targets involving NRF2.

    DOI: 10.1073/pnas.2000278117

    PubMed

  4. Seasonal regulation of the lncRNA LDAIR modulates self-protective behaviours during the breeding season Reviewed International journal

    Tomoya Nakayama, *, Tsuyoshi Shimmura, Ai Shinomiya, Kousuke Okimura, Yusuke Takehana, Yuko Furukawa, Takayuki Shimo, Takumi Senga, Mana Nakatsukasa, Toshiya Nishimura, Minoru Tanaka, Kataaki Okubo, Yasuhiro Kamei, Kiyoshi Naruse, Takashi Yoshimura, Equal contribution

    Nature Ecology & Evolution   Vol. 3 ( 5 ) page: 1 - 8   2019.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    DOI: 10.1038/s41559-019-0866-6

  5. Dynamic plasticity in phototransduction regulates seasonal changes in color perception Reviewed International journal

    Tsuyoshi Shimmura, Tomoya Nakayama, Ai Shinomiya, Shoji Fukamachi, Masaki Yasugi, Eiji Watanabe, Takayuki Shimo, Takumi Senga, Toshiya Nishimura, Minoru Tanaka, Yasuhiro Kamei, Kiyoshi Naruse, Takashi Yoshimura

    Nature Communications   Vol. 8 ( 1 )   2017.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

    To cope with seasonal changes in the environment, organisms adapt their physiology and behavior. Although color perception varies among seasons, the underlying molecular basis and its physiological significance remain unclear. Here we show that dynamic plasticity in phototransduction regulates seasonal changes in color perception in medaka fish. Medaka are active and exhibit clear phototaxis in conditions simulating summer, but remain at the bottom of the tank and fail to exhibit phototaxis in conditions simulating winter. Mate preference tests using virtual fish created with computer graphics demonstrate that medaka are more attracted to orange-red-colored model fish in summer than in winter. Transcriptome analysis of the eye reveals dynamic seasonal changes in the expression of genes encoding photopigments and their downstream pathways. Behavioral analysis of photopigment-null fish shows significant differences from wild type, suggesting that plasticity in color perception is crucial for the emergence of seasonally regulated behaviors.

    DOI: 10.1038/s41467-017-00432-8

    Web of Science

  6. Prostaglandin E2 synchronizes lunar-regulated beach spawning in grass puffers Reviewed International journal

    Junfeng Chen, Yuma Katada, Kousuke Okimura, Taiki Yamaguchi, Ying-Jey Guh, Tomoya Nakayama, Michiyo Maruyama, Yuko Furukawa, Yusuke Nakane, Naoyuki Yamamoto, Yoshikatsu Sato, Hironori Ando, Asako Sugimura, Kazufumi Tabata, Ayato Sato, Takashi Yoshimura

    Current Biology   Vol. 32 ( 22 ) page: 4881 - 4889.e5   2022.10

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.cub.2022.09.062

  7. Novel hypnotics of Japanese traditional herbal medicines to caffeine-induced insomnia in Drosophila by using Newly-developed automated sleep and rhythm analysis system (AutoCircaS). Reviewed International journal

    Eiji Inoue, Takahiro Suzuki, Tomoya Nakayama, Takashi Yoshimura, Keiichi Sudo, Yasuharu Shimizu, Yoshikazu Iwaki, Haruhisa Kawasaki, Norio Ishida

    Gene     page: 146852 - 146852   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    Sleep in Drosophila was defined in the year 2000 by using Drosophila Activity Monitor (DAM) system. But DAM is very small tube space and one fly per tube is very limited to analyze for fly social behavior. To overcome such demerits of DAM system, we developed a novel automated sleep and rhythm analysis system (AutoCircaS) which monitors and records any behaviors like social mating, sleep, and circadian rhythm in flies (Drosophila) and small fishes medaka (Oryzias latipes) in free space using the time-lapse (one frame per 10 sec) imaging. AutoCircaS can detect the caffeine-induced insomnia in flies in light-dark (LD) and constant dark (DD) conditions. Thus, using the AutoCircaS, we discovered that Japanese traditional herbal medicines, KyushinKannouGan-ki (KKG), NouKassei (NK) as well as, and Sansoninto, significantly improved caffeine-induced insomnia in flies. The data suggest that AutoCircaS is useful for sleep analysis of small animals and screening of new sedative-hypnotics from many origins.

    DOI: 10.1016/j.gene.2022.146852

    PubMed

  8. Indirect pathway to pectoral fin motor neurons from nucleus ruber in the Nile tilapia Oreochromis niloticus Reviewed International journal

    Tomoya Nakayama, Hirotaka Nishino, Junya Narita, Hideki Abe, Naoyuki Yamamoto

    Journal of Comparative Neurology   Vol. 527   page: 957 - 971   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cne.24578

  9. Seasonal changes in color perception Reviewed International journal

    Tsuyoshi Shimmura, Tomoya Nakayama, Ai Shinomiya, Takashi Yoshimura

    General and Comparative Endocrinology   Vol. 260   page: 171 - 174   2018.5

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    Language:English   Publisher:Academic Press Inc.  

    In temperate zones, organisms experience dynamic fluctuations in environment including changes in color. To cope with such seasonal changes in the environment, organisms adapt their physiology and behavior. Although color perception has been believed to be fixed throughout life, there is increasing evidence for the alteration in opsin gene expression induced by environmental stimuli in a number of animals. Very recently, dynamic seasonal plasticity in color perception has been reported in the seasonally breeding medaka fish. Interestingly, seasonal changes in human color perception have also been reported. Therefore, plasticity of color perception, induced by environmental stimuli, might be a common phenomenon across various species.

    DOI: 10.1016/j.ygcen.2017.12.010

    Scopus

  10. Seasonal Rhythms: The Role of Thyrotropin and Thyroid Hormones Reviewed International journal

    Tomoya Nakayama, Takashi Yoshimura

    Thyroid   Vol. 28 ( 1 ) page: 4 - 10   2018.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Mary Ann Liebert Inc  

    DOI: 10.1089/thy.2017.0186

  11. Descending pathways to the spinal cord in comparison with mammals, with special attention to rubrospinal pathways Reviewed International journal

    Yamamoto N, Hagio H, Nakayama T

    Development Growth and Differentiation   Vol. 59 ( 4 ) page: 199-193 - 193   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    In this article we review descending neural pathways to the spinal cord in teleosts, compared with mammals. Descending pathways to the spinal cord are crucial in controlling various behaviors in vertebrates. The major difference between teleosts and mammals is the lack of corticospinal (or palliospinal) tracts. Other descending pathways, which originate from the brain stem, are basically identical in teleosts and mammals. This suggests the presence of common systems in the spinal motor control by higher order centers. The homologue of nucleus ruber remained unclear in teleosts until recently, and this review pays special attention to the rubrospinal tract.

    DOI: 10.1111/dgd.12355

    Web of Science

  12. Nucleus Ruber of Actinopterygians Reviewed International journal

    Tomoya Nakayama, Satoshi Miyajima, Hirotaka Nishino, Junya Narita, Hideki Abe, Naoyuki Yamamoto

    Brain, Behavior and Evolution   Vol. 88 ( 1 ) page: 25 - 42   2016

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:KARGER  

    Nucleus ruber is known as an important supraspinal center that controls forelimb movements in tetrapods, and the rubral homologue may serve similar functions in fishes (motor control of pectoral fin). However, two apparently different structures have been identified as 'nucleus ruber' in actinop-terygians. One is nucleus ruber of Goldstein (1905) (NRg), and the other nucleus ruber of Nieuwenhuys and Pouwels (1983) (NRnp). It remains unclear whether one of these nuclei (or perhaps both) is homologous to tetrapod nucleus ruber. To resolve this issue from a phylogenetic point of view, we have investigated the distribution of tegmental neurons retrogradely labeled from the spinal cord in eight actinopterygian species. We also investigated the presence/absence of the two nuclei with Nissl- or Bodian-stained brain section series of an additional 28 actinopterygian species by comparing the morphological features of candidate rubral neurons with those of neurons revealed by the tracer studies. Based on these analyses, the NRg was identified in all actinopterygians investigated in the present study, while the NRnp appears to be absent in basal actinopterygians. The phylogenetic distribution pattern indicates that the NRg is the more likely homologue of nucleus ruber, and the NRnp may be a derived nucleus that emerged during the course of actinopterygian evolution. (C) 2016 S. Karger AG, Basel

    DOI: 10.1159/000447442

    Web of Science

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Books 1

  1. Identification and Characterization of Genes Involved in Vertebrate Photoperiodism

    Tomoya Nakayama, Kataaki Okubo, Satoshi Ansai, Takashi Yoshimura

    2022.9 

MISC 6

  1. メダカの見ている世界 ー眼の光感受性と色覚の季節変化についてー

    中山友哉, 吉村崇

    月刊アクアライフ 2023年5月号     2023.5

  2. メダカに学ぶ脊椎動物の冬季適応戦略 Reviewed

    中山友哉, 吉村崇

    低温科学   Vol. 81   page: 61 - 70   2023.3

  3. Identification and Characterization of Genes Involved in Vertebrate Photoperiodism

    Tomoya Nakayama, Kataaki Okubo, Satoshi Ansai, Takashi Yoshimura

    Circadian Clocks (Neuromethods)     2022.9

  4. ケミカルゲノミクスで明らかにするメダカの冬季うつ様行動の分子基盤 Reviewed

    沖村 光祐, 中山 友哉, 吉村 崇

    化学と生物   Vol. 59 ( 8 ) page: 369 - 376   2021.8

  5. 脊椎動物の季節感知機構の解明とその応用 動物たちの季節適応戦略の謎に迫る Invited Reviewed

    中山 友哉, 中根 右介, 吉村 崇

    化学と生物   Vol. 57 ( 2 ) page: 121 - 128   2019.1

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    Language:Japanese  

  6. The 64th NIBB Conference: Evolution of Seasonal Timers

    中山友哉

    日本進化学会ニュース     2016.7

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    Language:Japanese  

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Presentations 27

  1. シングルセルマルチオミクスによる日長応答性を示す機能未知遺伝子の解析

    中山友哉, 吉村崇

    2023年度「先進ゲノム支援」拡大班会議  2023.12.25 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Poster presentation  

  2. ⽇⻑応答性を⽰す機能未知遺伝⼦の解析

    中山友哉, 吉村崇

    生物リズム若手研究者の集い2023  2023.11.26 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Poster presentation  

  3. 光周反応を示す機能未知遺伝子の発現制御機構の解析

    中山友哉, 吉村崇

    日本睡眠学会第45回定期学術集会・ 第30回日本時間生物学会学術大会 合同大会  2023.9.16 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Poster presentation  

  4. 光情報の季節変化によって制御される動物の生理機能や行動の仕組み Invited

    中山友哉

    日本動物学会 第94回山形大会  2023.9.7 

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    Event date: 2023.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  5. メダカの季節温度適応におけるトランスクリプトーム解析

    中山友哉, 鹿島誠, 成瀬清, 吉村崇

    令和5年度日本水産学会春季大会  2023.3.30 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  6. Transcriptome analysis of the low temperature response in fish using medaka as a model

    Tomoya Nakayama, Makoto Kashima, Kiyoshi Naruse, Takashi Yoshimura

    2023.3.18 

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    Event date: 2023.3

    Language:English   Presentation type:Oral presentation (general)  

  7. 日長応答性を示す機能未知遺伝子の発現制御機構の解析

    中山友哉

    2022年度「先進ゲノム支援」拡大班会議  2023.1.19 

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    Event date: 2023.1

    Presentation type:Poster presentation  

  8. メダカから明らかとなった動物の季節適応戦略の分子基盤 Invited

    中山友哉

    生物リズム若手研究者の集い2022  2022.12.5 

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    Event date: 2022.12

    Presentation type:Oral presentation (invited, special)  

  9. 光周反応を示す機能未知遺伝子の機能解析

    中山友哉, 安齋賢, Romain Fontaine, Christiaan Henkel, 成瀬清, 吉村崇

    第29回日本時間生物学会学術大会  2022.12.3 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Poster presentation  

  10. メダカから探る魚類の季節適応機構 Invited

    中山友哉, 吉村崇

    日本動物学会 第93回早稲田大会  2022.9.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  11. トランスクリプトーム解析より明らかになった光周性反応を示す機能未知遺伝子

    中山友哉, 安齋賢, 成瀬清, 吉村崇

    令和4年度公益社団法人日本水産学会 春季大会  2022.3.28 

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    Event date: 2022.3

    Language:Japanese  

  12. トランスクリプトーム解析より明らかになった光周性反応を示す機能未知遺伝子

    中山友哉, 安齋賢, 成瀬清, 吉村崇

    令和4年度公益社団法人日本水産学会 春季大会  2022.3.28 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  13. Functional analysis of novel gene that shows photoperiodic responsiveness in medaka fish

    Tomoya Nakayama, Satoshi Ansai, Kiyoshi Naruse, Takashi Yoshimura

    2022.3.14 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

  14. Functional analysis of novel gene that shows photoperiodic responsiveness in medaka fish

    Tomoya Nakayama, Satoshi Ansai, Kiyoshi Naruse, Takashi Yoshimura

    第69回 日本生態学会大会  2022.3.14 

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    Event date: 2022.3

    Language:English   Presentation type:Oral presentation (general)  

  15. 長鎖ノンコーディングRNAであるLDAIRは自己防衛行動の季節変化を制御する

    中山友哉, 新村毅, 四宮愛, 沖村光祐, 竹花佑介, 古川祐子, 下貴行, 千賀琢未, 中務真愛, 西村俊哉, 田中実, 大久保範聡, 亀井保博, 成瀬清, 吉村崇

    第26回日本時間生物学会学術大会  2019.10.12 

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    Event date: 2019.10

    Language:Japanese   Presentation type:Poster presentation  

  16. Seasonal regulation of the lncRNA LDAIR modulates self-protective behaviors during the breeding season Invited International conference

    Tomoya Nakayama, Tsuyoshi Shimmura, Ai Shinomiya, Kousuke Okimura, Yusuke Takehana, Yuko Furukawa, Takayuki Shimo, Takumi Senga, Mana Nakatsukasa, Toshiya Nishimura, Minoru Tanaka, Kataaki Okubo, Yasuhiro Kamei, Kiyoshi Naruse, Takashi Yoshimura

    the 1st International Exchange Symposium of Zoology: Invitation to Neuroscience  2019.9 

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    Event date: 2019.9

    Language:English   Presentation type:Oral presentation (invited, special)  

  17. Seasonal regulation of the lncRNA LDAIR modulates self-protective behaviors during the breeding season International conference

    Tomoya Nakayama, Tsuyoshi Shimmura, Ai Shinomiya, Kousuke Okimura, Yusuke Takehana, Yuko Furukawa, Takayuki Shimo, Takumi Senga, Mana Nakatsukasa, Toshiya Nishimura, Minoru Tanaka, Kataaki Okubo, Yasuhiro Kamei, Kiyoshi Naruse, Takashi Yoshimura

    XVI European Biological Rhythms Society Congress  2019.8 

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    Event date: 2019.8

    Language:English   Presentation type:Poster presentation  

  18. Molecular mechanism of seasonal adaptation in medaka Invited International conference

    Tomoya Nakayama, Tsuyoshi Shimmura, Ai Shinomiya, Yusuke Takehana, Shoji Fukamachi, Masaki Yasugi, Eiji Watanabe, Toshiya Nishimura, Minoru Tanaka, Kataaki Okubo, Yasuhiro Kamei, Kiyoshi Naruse, Takashi Yoshimura

    The 14th International Zebrafish Conference  2019.6 

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    Event date: 2019.6

    Language:English   Presentation type:Oral presentation (invited, special)  

  19. Transcriptome analysis of spring-responsive genes in medaka (Oryzias latipes) International conference

    Tomoya Nakayama, Tsuyoshi Shimmura, Ai Shinomiya, Yusuke Takehana, Takayuki Shimo, Takumi Senga, Toshiya Nishimura, Minoru Tanaka, Yasuhiro Kamei, Kiyoshi Naruse, Takashi Yoshimura

    Society for Research on Biological Rhythms  2018.5 

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    Event date: 2018.5

    Language:English   Presentation type:Poster presentation  

  20. メダカの春季適応機構におけるトランスクリプトーム解析

    中山 友哉

    第2回名古屋リズム研究会  2018.3 

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    Event date: 2018.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  21. 光情報伝達経路のダイナミックな可塑性が色覚の季節変化を制御する

    新村毅, 中山友哉, 四宮愛, 深町昌司, 八杉公基, 渡辺英治, 下貴行, 千賀琢未, 西村俊哉, 田中実, 亀井保博, 成瀬清, 吉村崇

    第24回日本時間生物学会学術大会  2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Poster presentation  

  22. メダカにおける秋季適応機構

    中山友哉, 新村毅, 四宮愛, 下貴行, 千賀琢未, 西村俊哉, 田中実, 成瀬清, 吉村崇

    日本動物学会 第88回富山大会  2017.9 

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    Event date: 2017.9

    Language:Japanese   Presentation type:Poster presentation  

  23. Transcriptome analysis of autumn-resposive genes in medaka (Oryzias latipes) International conference

    Tomoya Nakayama, Tsuyoshi Shimmura, Ai Shinomiya, Takayuki Shimo, Takumi Senga, Toshiya Nishimura, Minoru Tanaka, Kiyoshi Naruse, Takashi Yoshimura

    International Symposium on Biological Rhythms “Towards understanding the molecular clockwork”  2016.11 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

  24. メダカの秋季応答におけるトランスクリプトーム解析

    中山友哉, 新村毅, 四宮愛, 下貴行, 千賀琢未, 西村俊哉, 田中実, 成瀬清, 吉村崇

    第23回日本時間生物学会学術大会  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Poster presentation  

  25. Genome-wide expression analysis of genes in response to the autumn season in medaka (Oryzias latipes)

    2016.8 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Poster presentation  

  26. Genome-wide expression analysis of genes in response to the autumn season in medaka (Oryzias latipes) International conference

    Tomoya Nakayama, Tsuyoshi Shimmura, Ai Shinomiya, Takayuki Shimo, Takumi Senga, Toshiya Nishimura, Minoru Tanaka, Kiyoshi Naruse, Takashi Yoshimura

    Evolution of seasonal timers  2016.4 

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    Event date: 2016.4

    Language:English   Presentation type:Poster presentation  

  27. 生きものは季節をどうやって知る? Invited

    中山友哉

    日本自然保護協会 NACS-J市民カレッジ  2022.5.30 

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    Language:Japanese  

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. 脊椎動物が日長の変化を読み取り、季節適応する仕組みの解明

    2024.4 - 2027.3

    日本学術振興会 科学研究費助成事業  若手研究 

    中山 友哉

  2. 変温動物の低温耐性の分子基盤の解明から明らかにする冬眠の分子機構

    2024.4 - 2026.3

    日本学術振興会 科学研究費助成事業  学術変革領域研究(A)(公募研究) 

    中山 友哉

  3. 柔軟性と頑健性を備えた季節温度適応能の分子基盤の解明

    2024.4 - 2025.3

    国立研究開発法人 科学技術振興機構(JST)  ACT-X「環境とバイオテクノロジー」加速フェーズ 

    中山 友哉

  4. 日長応答性を示す機能未知遺伝子の機能解明

    2022.9 - 2023.3

    「先進ゲノム支援」(先進ゲノム解析研究推進プラットフォーム)支援課題 

    中山 友哉

  5. 柔軟性と頑健性を備えた季節温度適応能の分子基盤の解明

    2021.10 - 2024.3

    国立研究開発法人 科学技術振興機構(JST)  ACT-X「環境とバイオテクノロジー」 

    中山 友哉

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    Authorship:Principal investigator 

  6. 日長応答性を示す機能未知遺伝子の機能解明

    Grant number:20K15840  2020.4 - 2024.3

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    中山 友哉

  7. Understanding the seasonal adaptation mechanism and its application

    Grant number:19H05643  2019.6 - 2024.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (S)

  8. メダカの秋季感知機構の解明

    Grant number:18J10936  2018.4 - 2020.3

    日本学術振興会  科学研究費助成事業 特別研究員奨励費  特別研究員奨励費

    中山 友哉

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    近年の研究から季節繁殖の制御機構は明らかになってきたものの、行動の季節変化などの動物の季節適応機構の分子基盤はほとんど明らかにされていない。短日条件から長日条件へと移行した際の脳の時系列サンプルを用いて、DNAマイクロアレイによるトランスクリプトーム解析が実施されたところ、多数の転写産物やシグナル伝達経路が長日刺激によって変動していることが明らかとなった。その中には長日条件移行後にほかの転写産物に先駆けて誘導される機能未知な長鎖ノンコーディングRNAであるLDAIRが含まれていた。LDAIRノックアウト(KO)メダカを用いたトランスクリプトーム解析を行ったところ、LDAIRはストレス反応に関与するコルチコトロピン放出ホルモン受容体2(CRHR2)を含む近傍遺伝子の発現を制御していることが明らかとなった。LDAIR KOメダカを作製し、ストレス応答を評価したところ、長日条件で飼育された野生型のメダカはLDAIR KOメダカと比べてストレスに敏感であり、危険な状況を避けることが明らかとなった。以上の結果より、LDAIRによるCRHR2の日長制御は繁殖期における自己防衛行動を制御していることが明らかとなった。
    メダカは春に繁殖を開始し、秋に繁殖を停止する長日繁殖動物であるが、動物がどのように秋を感知し、繁殖を停止しているかについては依然として明らかとなっていない。これまでの長日条件から短日条件へと移行した際の脳の時系列サンプルを用いたDNAマイクロアレイ解析により短日刺激に応じて様々な遺伝子の発現が変動することが明らかとなっていた。また、新たにRNA-seq解析からメダカは短日刺激によりいくつかの遺伝子のスプライシングパターンを変化させていることも明らかとなった。

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Teaching Experience (Off-campus) 5

  1. 名古屋大学PhD登龍門ヤングメンターコース

    2021.1 - 2021.10

  2. 動物生理学1

    2020.4 Nagoya University)

  3. 資源生物科学実験実習2

    2020.4 Nagoya University)

  4. 動物生理学特論Ⅰ

    2020.4

  5. Animal physiology2

    2020.4 Nagoya University)

 

Social Contribution 2

  1. 高校出前講義

    Role(s):Lecturer

    岐阜県立多治見北高等学校  2021.11

  2. 進路探求特別講座

    Role(s):Lecturer

    名古屋市立菊里高等学校  2020.11