2023/10/26 更新

写真a

カドマツ ユカ
門松 由佳
KADOMATSU Yuka
所属
医学部附属病院 呼吸器外科 病院助教
職名
病院助教

学位 1

  1. 博士(医学) ( 2021年3月   名古屋大学 ) 

研究分野 1

  1. ライフサイエンス / 呼吸器外科学  / 原発性自然気胸、肺癌

経歴 1

  1. 名古屋大学   病院助教

    2020年4月 - 現在

学歴 2

  1. 名古屋大学   医学部   博士課程

    2017年4月 - 2021年3月

  2. 名古屋大学   医学部   医学科

    2002年4月 - 2008年3月

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    国名: 日本国

所属学協会 6

  1. 日本臨床疫学会

    2020年5月 - 現在

  2. 日本疫学学会

    2017年12月 - 現在

  3. 日本胸部外科学会

    2011年5月 - 現在

  4. 日本呼吸器外科学会   評議員

    2011年5月 - 現在

  5. 日本肺癌学会

    2010年12月 - 現在

  6. 日本外科学会   専門医

    2010年3月 - 現在

▼全件表示

 

論文 55

  1. Differential impacts of postoperative complications on patients' survival in completely resected non-small-cell lung cancer 査読有り

    Yuka Kadomatsu, Hideki Tsubouchi, Keita Nakanishi, Tomoshi Sugiyama, Harushi Ueno, Masaki Goto, Naoki Ozeki, Shota Nakamura, Takayuki Fukui, Toyofumi Fengshi Chen-Yoshikawa

    Gen Thorac Cardiovasc Surg .     2021年3月

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    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1007/s11748-021-01619-z.

  2. New method for delineation of the intersegmental line in a deflated lung

    Okado Shoji, Kadomatsu Yuka, Nakao Megumi, Ueno Harushi, Fukumoto Koichi, Nakamura Shota, Chen-Yoshikawa Toyofumi Fengshi

    JOURNAL OF THORACIC DISEASE   15 巻 ( 9 ) 頁: 4736 - 4744   2023年8月

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    記述言語:英語  

    DOI: 10.21037/jtd-23-421

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  3. Prognostic impact of highly solid component in early-stage solid lung adenocarcinoma

    Kato Taketo, Iwano Shingo, Hanamatsu Yuki, Nakaguro Masato, Emoto Ryo, Okado Shoji, Sato Keiyu, Noritake Osamu, Nakanishi Keita, Kadomatsu Yuka, Ueno Harushi, Ozeki Naoki, Nakamura Shota, Fukumoto Koichi, Takeuchi Tamotsu, Karube Kennosuke, Matsui Shigeyuki, Chen-Yoshikawa Toyofumi Fengshi

    QUANTITATIVE IMAGING IN MEDICINE AND SURGERY   13 巻 ( 9 ) 頁: 5641 - 5652   2023年7月

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    記述言語:英語   出版者・発行元:Quantitative Imaging in Medicine and Surgery  

    Background: Based on computed tomography (CT) findings of lung cancer, solid nodules have a much worse prognosis than subsolid nodules, even if the nodules are subcentimeter in size. There is, however, no systematic method for determining the prognosis of solid tumors on CT. This study aimed to discover the prognostic factor of early-stage solid lung adenocarcinoma using three-dimensional CT volumetry. Methods: Patients with pathological stage I solid lung adenocarcinoma who underwent complete resection between 2007 and 2012 were selected in this retrospective study. Clinicopathological data and preoperative multidetector CT findings, such as tumor size on the two-dimensional axial image, three-dimensional tumor volume between -600 and 199 HU, and three-dimensional solid volume between 0 and 199 HU, which corresponded to highly solid components, were compared between recurrence and non-recurrence. Furthermore, these radiological values were compared to pathological invasive volume (PIV). Results: During this time, 709 patients had their lung cancer completely removed. From this cohort, 90 patients with pathological stage I solid lung adenocarcinoma were selected. In addition, recurrence was found in 26 patients (28.9%). Although two-dimensional axial image, serum carcinoembryonic antigen (CEA) level, and SUVmax on 18F fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/ CT) did not differ statistically between recurrent and non-recurrent patients, three-dimensional tumor and solid tumor volume did. Multivariate analysis indicated that three-dimensional solid tumor volume [hazard ratio: 2.440; 95% confidence interval (CI): 1.110-5.361, P=0.026] and epidermal growth factor receptor (EGFR) mutation (hazard ratio: 4.307; 95% CI: 1.328-13.977, P=0.015) were significantly associated with disease-free survival (DFS). When three-dimensional tumor and solid tumor volume were compared to PIV, three-dimensional solid tumor volume (3,091 mm3 on average) showed a highly similar value with PIV (2,930 mm3 on average), whereas three-dimensional tumor volume (6,175 mm3 on average) was significantly larger than PIV (P<0.001). Conclusions: In patients with early-stage solid lung adenocarcinoma, the measurement of threedimensional solid tumor volume, which is correlated with PIV, accurately predicted the postoperative outcome.

    DOI: 10.21037/qims-23-36

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  4. Association of daily physical activity and leisure-time exercise with dysphagia risk in community-dwelling older adults: a cross-sectional study

    Maehara Tomoko, Nishimura Rumi, Yoshitake Akari, Tsukamoto Mineko, Kadomatsu Yuka, Kubo Yoko, Okada Rieko, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Takeuchi Kenji, Wakai Kenji, Naito Mariko

    SCIENTIFIC REPORTS   13 巻 ( 1 ) 頁: 10893   2023年7月

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    記述言語:英語   出版者・発行元:Scientific Reports  

    This study aimed to clarify the association of daily physical activity and leisure-time exercise with the risk of dysphagia in community-dwelling Japanese older adults using a questionnaire-based survey. We analyzed 3070 participants (1657 men, 1413 women; age 66 ± 4 years [mean ± SD]) of the Shizuoka and Daiko studies within the Japanese Multi-Institutional Collaborative Cohort study. We used the Dysphagia Risk Assessment for the Community-dwelling Elderly questionnaire to assess dysphagia risk and the International Physical Activity Questionnaire to assess daily physical activity and leisure-time exercise. Logistic regression analyses were used to evaluate the independent association of the amount of physical activity and leisure-time exercise with dysphagia risk. The proportion of participants with dysphagia risk was 27.5% (n = 844) and the risk was significantly higher in women (29.8%, n = 421) than in men (25.5%, n = 423; P = 0.008). Daily physical activity was not associated with dysphagia risk. A greater amount of leisure-time exercise was associated with lower dysphagia risk (P for trend = 0.003) and individuals in the highest leisure-time exercise quartile had a significantly lower odds ratio (0.68, 95% CI 0.52–0.89) than those in the lowest quartile, even after adjusting for the covariates.

    DOI: 10.1038/s41598-023-37605-z

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  5. Setting a quality indicator for actual surgery time relative to scheduled surgery time in the context of increasing robotic-assisted thoracic surgery cases

    Ozeki Naoki, Ueno Harushi, Saeki Jun, Kadomatsu Yuka, Kato Taketo, Nakamura Shota, Fukumoto Koichi, Fukui Takayuki, Chen-Yoshikawa Toyofumi Fengshi

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   71 巻 ( 7 ) 頁: 396 - 402   2023年7月

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    記述言語:英語   出版者・発行元:General Thoracic and Cardiovascular Surgery  

    Objective: This study aimed to demonstrate to the involved departments the goal of increasing the number of robotic-assisted thoracic surgery (RATS) cases/surgeons and acceptable surgery times. Methods: This retrospective study included 1572 patients who underwent thoracic surgery from fiscal year (FY) 2018 to FY 2021. The factors evaluated included the number of surgery cases and actual and scheduled surgery times. Results: The total number of RATS and total surgery cases increased after the quality indicator (QI) setting (n = 363, 360, 417, and 432 in FY 2018, 2019, 2020, and 2021, respectively). In FY 2020, 93.3% of the QI target was achieved, while in FY 2021, 88% was achieved. The number of RATS lobectomy/segmentectomy increased as the FY progressed (n = 31, 47, 58, and 116 in FY 2018, 2019, 2020, and 2021, respectively). The mean surgical time by RATS starters decreased in FY 2020 and 2021 (171.4 min.; 74 cases; seven RATS starters) compared with those in FY 2018 and 2019 (198.0 min.; 57 cases; six RATS starters) (P = 0.002). Conclusions: The goal of increasing the number of surgery cases and RATS cases/surgeons within the given framework was achieved by setting the QI.

    DOI: 10.1007/s11748-022-01903-6

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  6. Lingular-segment torsion after extended left-upper division segmentectomy by video-assisted thoracic surgery with indocyanine green fluorescence imaging

    Kato Taketo, Ohara Yuko, Okado Shoji, Noritake Osamu, Nakanishi Keita, Kadomatsu Yuka, Ueno Harushi, Nakamura Shota, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   16 巻 ( 3 ) 頁: 584 - 587   2023年7月

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    記述言語:英語   出版者・発行元:Asian Journal of Endoscopic Surgery  

    Lingular-segment torsion after left-upper division segmentectomy (LUDS) is a rare complication, and the cause remains unclear. Here we report the case of a patient who developed lingular-segment torsion after LUDS for multiple lung metastases of breast cancer. One lung nodule was located in the S1 + 2 segment and another between the upper lobe and S6 on an incomplete interlobar fissure. The lung metastases were resected by extended LUDS using video-assisted thoracic surgery with indocyanine green fluorescence imaging. The staple line on the lingular segment was vertically tilted against the interlobar line because of the atypical defect of the fluorescence plane and nodule position. Chest X-ray and contrast-enhanced computed tomography indicated ischemia and torsion of the lingular segment on the second postoperative day, and completion of lingular segmentectomy was performed. This case showed the vertical intersegment staple line during LUDS was one of the important causes of postoperative torsion of the lingular segment.

    DOI: 10.1111/ases.13189

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  7. [Robot-assisted Extended Thymectomy via a Bilateral Approach for Patients with Myasthenia Gravis].

    Nakamura S, Nakanishi K, Kadomatsu Y, Ueno H, Kato T, Chen-Yoshikawa TF

    Kyobu geka. The Japanese journal of thoracic surgery   76 巻 ( 7 ) 頁: 523 - 527   2023年7月

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    記述言語:日本語  

    PubMed

  8. Robotic resection of ectopic mediastinal parathyroid adenoma in multiple endocrine neoplasia 1

    Ohara Yuko, Kadomatsu Yuka, Kikumori Toyone, Chen-Yoshikawa Toyofumi F.

    SURGICAL CASE REPORTS   9 巻 ( 1 ) 頁: 114   2023年6月

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  9. Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study

    Hara Megumi, Nishida Yuichiro, Tanaka Keitaro, Shimanoe Chisato, Koga Kayoko, Furukawa Takuma, Higaki Yasuki, Shinchi Koichi, Ikezaki Hiroaki, Murata Masayuki, Takeuchi Kenji, Tamura Takashi, Hishida Asahi, Tsukamoto Mineko, Kadomatsu Yuka, Matsuo Keitaro, Oze Isao, Mikami Haruo, Kusakabe Miho, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Nakagawa-Senda Hiroko, Matsui Daisuke, Koyama Teruhide, Kuriki Kiyonori, Takashima Naoyuki, Nakamura Yasuyuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Wakai Kenji

    JOURNAL OF EPIDEMIOLOGY   33 巻 ( 6 ) 頁: 285 - 293   2023年6月

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    記述言語:英語   出版者・発行元:Journal of Epidemiology  

    Background: Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function. Methods: We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m2. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied. Results: After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (P for trend MVPA <0.0001) and lower eGFR (P for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68–0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52–2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD. Conclusion: These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.

    DOI: 10.2188/jea.JE20210155

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    CiNii Research

  10. Clinical application of resection process map as a novel surgical guide in thoracic surgery

    Kadomatsu Yuka, Nakao Megumi, Ueno Harushi, Nakamura Shota, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY   36 巻 ( 4 )   2023年4月

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  11. Video-assisted thoracoscopic surgery for pleuroperitoneal communication

    Tsubouchi Hideki, Nakamura Shota, Fukui Takayuki, Kadomatsu Yuka, Ueno Harushi, Ozeki Naoki, Fukumoto Koichi, Mizuno Masashi, Chen-Yoshikawa Toyofumi F.

    ASIAN JOURNAL OF ENDOSCOPIC SURGERY   16 巻 ( 2 ) 頁: 262 - 265   2023年4月

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    記述言語:英語   出版者・発行元:Asian Journal of Endoscopic Surgery  

    Here we report the cases of five patients on continuous ambulatory peritoneal dialysis (CAPD) who developed hydrothorax because of pleuroperitoneal communication. Preoperative computed tomography (CT) peritoneography revealed penetrated sites on the diaphragm in all patients. All patients underwent video-assisted thoracoscopic surgery (VATS), and a dialysate containing indigo carmine was injected intraperitoneally through a CAPD catheter to confirm the fistula. In all patients, a thinned bleb was found at the center of the diaphragmatic tendon consistent with that noted on preoperative CT peritoneography. The bleb was resected using a surgical stapler in four patients, and the pleuroperitoneal communication did not recur. However, in one patient, the bleb was only covered with reinforcement agents and the hydrothorax recurred after CAPD. This study demonstrates that VATS treatment for pleuroperitoneal communication is safe and effective but that lesion resection would be more useful for preventing hydrothorax recurrence in patients undergoing CAPD.

    DOI: 10.1111/ases.13127

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  12. Real-world evidence of safety and influence for lung cancer surgery under COVID-19 pandemic in Japan

    Kato Taketo, Katsuya Ryotaro, Okado Shoji, Sato Keiyu, Noritake Osamu, Nakanishi Keita, Noguchi Misa, Kadomatsu Yuka, Ueno Harushi, Ozeki Naoki, Nakamura Shota, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    JOURNAL OF THORACIC DISEASE   15 巻 ( 2 ) 頁: 542 - +   2023年2月

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    記述言語:英語   出版者・発行元:Journal of Thoracic Disease  

    Background: The COVID-19 pandemic has affected the clinical practice of lung cancer surgery in Japan, but few studies have revealed the real situation of surgical practice for lung cancer in this country. This latest information will help us to decide the future direction of lung cancer surgery under pandemic circumstances. Methods: We collected data from patients with primary lung cancer who underwent thoracic surgery between 2018 and 2021. To investigate the impact of the COVID-19 pandemic on lung cancer surgery, we compared between 2018–2019 (prepandemic group) and 2020–2021 (pandemic group) in the respect of patient characteristics, pathological findings, and short-term outcome after lung cancer resection by Mann-Whitney and Fisher’s exact tests. Moreover, the monthly number of surgeries for lung cancer in our institution during 2020–2021 was compared with the number of newly diagnosed COVID-19 patients in Japan by Spearman correlation analysis. Results: From 2018 through 2021, 936 patients with primary lung cancer underwent surgical intervention in our institute and were included in this study. The number of surgeries did not decrease in the pandemic group (n=443) compared with that in the prepandemic group (n=493). Tumor and invasive size in stage I which was measured by pathologist were significantly larger in the pandemic group than in the prepandemic group (tumor size: P=0.031, invasive size: P<0.001). In terms of postoperative short-term outcome, the median hospital stay was 6 days, 30-day mortality was 2, and morbidity was around 20% in both groups. Only one patient suffered from COVID-19 infection 5 months after right upper lobectomy. An increased ratio of newly diagnosed COVID-19 cases in Japan was negatively correlated with the number of surgeries for lung cancer in our institution in the next month (r=−0.393, P=0.007), although there was no correlation in the present or the month after next. Conclusions: Even during the COVID-19 pandemic period, lung cancer surgery could be performed safely and in a sustainable manner. However, pathological findings of lung cancer tended to be progressive in early-stage lung cancer.

    DOI: 10.21037/jtd-22-1289

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  13. ASO Visual Abstract: Impact of Pleural Thickness on the Occurrence of Postoperative Complications in Patients with Malignant Pleural Mesothelioma

    Ito Toshinari, Nakamura Shota, Kadomatsu Yuka, Ueno Harushi, Kato Taketo, Ozeki Naoki, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    ANNALS OF SURGICAL ONCOLOGY   30 巻 ( 3 ) 頁: 1586   2022年11月

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    記述言語:英語   出版者・発行元:Annals of surgical oncology  

    DOI: 10.1245/s10434-022-12860-y

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  14. Impact of Pleural Thickness on Occurrence of Postoperative Complications in Patients with Malignant Pleural Mesothelioma

    Ito Toshinari, Nakamura Shota, Kadomatsu Yuka, Ueno Harushi, Kato Taketo, Ozeki Naoki, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    ANNALS OF SURGICAL ONCOLOGY   30 巻 ( 3 ) 頁: 1574 - 1583   2022年11月

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    記述言語:英語   出版者・発行元:Annals of Surgical Oncology  

    Objectives: The rates of postoperative mortality and morbidity are high in patients with malignant pleural mesothelioma (MPM). Therefore, it is important to identify variables that increase the risk of postoperative complications. Pleural thickness has recently been identified as a prognostic indicator in patients with MPM. The aim of this study was to investigate clinical variables, including pleural thickness, that contribute to postoperative complications in patients with MPM. Patients and Methods: A total of 47 patients who underwent surgical excision of MPM between 2005 and 2021 were enrolled in this study. Correlations between postoperative complications within 90 days of surgery and preoperative clinical factors were investigated. Results: A total of 27 patients underwent extrapleural pneumonectomy (EPP), and the remaining 20 underwent pleurectomy/decortication (P/D). Macroscopic complete resections were obtained in all but three patients. Of the 47 patients, 23 (49%) experienced postoperative complications of grade 3 or worse. The major complication in patients with EPP was respiratory failure (n = 6), whereas the major complication in patients with P/D was prolonged air leakage (n = 7). Univariate logistic regression analysis found a correlation between postoperative complications and age, surgical side, and pleural thickness, while multivariate logistic regression analysis found surgical side (p = 0.04, 95% Cl 1.10–21.71, OR 4.90) and pleural thickness (p = 0.03, 95% Cl 1.21–23.00, OR 5.26) to significantly influence the occurrence of postoperative complications. Conclusions: Pleural thickness has a significant effect on the occurrence of postoperative complications. Patients with thick pleura on the right side are at greater risk of postoperative complications.

    DOI: 10.1245/s10434-022-12790-9

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  15. Neoadjuvant Therapy for Patients With Non-small Cell Lung Cancer Complicated With Chest Wall Invasion

    Sato Keiyu, Nakamura Shota, Kadomatsu Yuka, Ueno Harushi, Kato Taketo, Ozeki Naoki, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    ANTICANCER RESEARCH   42 巻 ( 11 ) 頁: 5539 - 5546   2022年11月

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    記述言語:英語   出版者・発行元:Anticancer Research  

    Background/Aim: Multidisciplinary treatment including anatomical pulmonary and chest wall resection is recommended for lung cancer complicated by chest wall invasion. The present study aimed to investigate the survival benefit and safety of preoperative therapy followed by surgery for non-small cell lung cancer with chest wall invasion. Patients and Methods: Sixty-five patients who underwent surgical excision of lung cancer complicated with chest wall invasion between 2009 and 2020 were enrolled in this study. Results: The median age was 65 (37-81) years old, with 59 males and 6 females. Histological types included squamous cell carcinoma (n=32) and adenocarcinoma (n=21). The median tumor diameter was 5.5 cm (2.3-12.5 cm). The clinical nodal status was N0 in 49 cases and N positive in 16 cases. Of the 65 eligible patients, 5- and 10-year overall survival (OS) rates were 58.4% and 46.0%, respectively, and 5- and 10-year progression-free survival (PFS) rates were 54.2% and 41.7%, respectively. For patients receiving preoperative therapy followed by surgery (Pre-Tx), 5- and 10-year OS survival rates were 69.2% and 62.9%, and among patients receiving up-front surgery (UFS) were 48.5% and 29.1%, respectively (p=0.03). The 5- and 10-year PFS rates for pre-Tx were 65.8% and 59.2%, respectively, and 44.7% and 26.8% for UFS, respectively (p=0.02). Cox regression analysis preoperative therapy was significantly associated with OS and PFS. Conclusion: We demonstrate the survival benefit of preoperative therapy followed by surgery for patients with lung cancer and chest wall invasion.

    DOI: 10.21873/anticanres.16059

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  16. Prognostic Value of Uncertain Resection for Overall Survival in Non-small Cell Lung Cancer

    Kadomatsu Yuka, Nakamura Shota, Ueno Harushi, Goto Masaki, Ozeki Naoki, Fukumoto Koichi, Fukui Takayuki, Suzuki Yuka, Chen-Yoshikawa Toyofumi Fengshi

    ANNALS OF THORACIC SURGERY   114 巻 ( 4 ) 頁: 1262 - 1268   2022年10月

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    記述言語:英語   出版者・発行元:Annals of Thoracic Surgery  

    Background: In this study we evaluated the R(un) category proposed by the International Association for the Study of Lung Cancer (IASLC) for non-small cell lung cancer (NSCLC). Methods: We retrospectively reviewed the medical records of patients with NSCLC who underwent segmentectomy or lobectomy between 2014 and 2015 at our institution. Residual tumor (R) status was reclassified from the Union for International Cancer Control designation to the IASLC-proposed R classification of R0 and R(un). The underlying reasons for the R(un) reclassification were analyzed according to pathologic stage, lymph node status, and resected lobe. A Cox proportional hazard model was used to evaluate the impacts of R(un) categorization on overall survival. Results: Of 355 patients, 44.5% were reclassified as R(un). The most common reason for the reclassification was insufficient number of harvested lymph nodes or no station 7 lymph nodes. When stratified by tumor location, the absence of station 7 lymph nodes was especially prominent in both the right and left upper lung resections. In the multivariate Cox regression model, the IASLC R classification was associated with poor overall survival in node-positive patients (hazard ratio, 2.657; P = .016). Conclusions: Various factors resulted in reclassification to R(un) because the R(un) group was highly heterogeneous. Careful consideration is required to determine whether the R(un) classification can be used as an indicator of lymph node dissection quality. For advanced cases, the R(un) definition may be useful in predicting poor prognosis.

    DOI: 10.1016/j.athoracsur.2021.07.087

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  17. A novel system applying artificial intelligence in the identification of air leak sites

    Kadomatsu Yuka, Nakao Megumi, Ueno Harushi, Nakamura Shota, Chen-Yoshikawa Toyofumi Fengshi

    JTCVS TECHNIQUES   15 巻   頁: 181 - 191   2022年10月

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    記述言語:英語   出版者・発行元:JTCVS Techniques  

    Objective: Prolonged air leak is the most common complication of thoracic surgery. Intraoperative leak site detection is the first step in decreasing the risk of leak-related postoperative complications. Methods: We retrospectively reviewed the surgical videos of patients who underwent lung resection at our institution. In the training phase, deep learning-based air leak detection software was developed using leak-positive endoscopic images. In the testing phase, a different data set was used to evaluate our proposed application for each predicted box. Results: A total of 110 originally captured and labeled images obtained from 70 surgeries were preprocessed for the training data set. The testing data set contained 64 leak-positive and 45 leak-negative sites. The testing data set was obtained from 93 operations, including 58 patients in whom an air leak was present and 35 patients in whom an air leak was absent. In the testing phase, our software detected leak sites with a sensitivity and specificity of 81.3% and 68.9%, respectively. Conclusions: We have successfully developed a deep learning-based leak site detection application, which can be used in deflated lungs. Although the current version is still a prototype with a limited training data set, it is a novel concept of leak detection based entirely on visual information.

    DOI: 10.1016/j.xjtc.2022.06.011

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  18. Computer-Aided Volumetry by Multidetector Computed Tomography is Efficient for Prognostic Prediction of Early-Stage Solid Lung Cancers

    Kato T., Iwano S., Katsuya R., Okado S., Ito T., Sato K., Nakanishi K., Kadomatsu Y., Ueno H., Ozeki N., Nakamura S., Fukumoto K., Chen-Yoshikawa T. F.

    JOURNAL OF THORACIC ONCOLOGY   17 巻 ( 9 ) 頁: S206 - S207   2022年9月

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  19. Skeletal muscle and related protein expression as prognostic factors in thymic squamous cell carcinoma

    Nakanishi Keita, Ozeki Naoki, Tateyama Hisashi, Kadomatsu Yuka, Ueno Harushi, Goto Masaki, Nakamura Shota, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    JOURNAL OF THORACIC DISEASE   14 巻 ( 9 ) 頁: 3245 - 3254   2022年9月

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    記述言語:英語   出版者・発行元:Journal of Thoracic Disease  

    Background: Sarcopenia and its marker, the psoas muscle index (PMI), have attracted attention as prognostic factors for various types of cancers. The fragile X-related 1 (FXR1) gene is highly expressed in myocytes, and FXR1 overexpression is a candidate biomarker for poor survival in several types of cancers. Thymic squamous cell carcinoma (TSQCC) is rare, and no studies assessing its prognostic factors, particularly in terms of skeletal muscle mass and FXR1 expression, are available. Methods: We retrospectively investigated the prognostic significance of PMI in 34 patients who underwent TSQCC resection, considering the status of FXR1 and tumor programmed death-ligand 1 (PD-L1). PMI was calculated from the bilateral psoas muscle using preoperative computed tomography (CT). Patients were divided into two groups: low PMI (<58.2%, n=17) and normal PMI (≥58.2%, n=17). Immunohistochemical analysis was performed to determine the FXR1 and PD-L1 expression levels. Results: Low PMI was significantly associated with worse overall survival (OS) (5-year survival rate; 86% vs. 100%; P=0.026) and marginally associated with worse disease-free survival (DFS) (5-year survival rate; 39% vs. 66%; P=0.090) compared with normal PMI. The immunohistochemical analysis revealed that the FXR1 intensity score (0–1+: 6% vs. 0%; 2+–3+: 94% vs. 100%; P=0.31), median FXR1 distribution (95% vs. 90%; P=0.63), and PD-L1 status (high: 47% vs. 59%; P=0.49) were not significantly different between the two groups. Conclusions: Our findings suggest that PMI might be considered as a potential prognostic factor in TSQCC and that FXR1 is widely expressed regardless of the PMI status. Skeletal muscle mass may play a role in the prognosis of TSQCC.

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  20. Relationship of smoking cessation period with the incidence of complications in lung cancer surgery

    Kadomatsu Yuka, Sugiyama Tomoshi, Sato Keiyu, Nakanishi Keita, Ueno Harushi, Goto Masaki, Ozeki Naoki, Nakamura Shota, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   62 巻 ( 3 )   2022年8月

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    記述言語:英語   出版者・発行元:European Journal of Cardio-thoracic Surgery  

    OBJECTIVES: The incidence of postoperative complications is relatively high in smokers. Although 4-week smoking cessation before surgery is generally recommended, it has not been sufficiently studied in lung cancer surgery. This study investigated whether smoking cessation for a short period of time significantly reduced complications after lung cancer surgery. METHODS: This was a retrospective, observational study that investigated the relationship between the smoking cessation period and the incidence of complications in lung cancer surgery. Patients who underwent curative-intent surgery for lung cancer at our institution between January 2014 and December 2017 were included. The smokers were classified into the following 4 categories of smoking cessation period before surgery: current (<4 weeks), recent (4 weeks to 12 months), distant (12 months to 5 years) and ex-smokers (>5 years). RESULTS: A total of 911 patients were included in this study. The incidence of pulmonary complications was 5 times higher in the smoker group than in the never smoker group (12.9% vs 2.5%, P < 0.001). On multivariable analysis in both models, the odds ratio for complications was significantly higher in distant smokers than in recent smokers and never smokers. Across all models, low lung function significantly predicted the development of postoperative complications. CONCLUSIONS: The evidence-based smoking cessation duration that reduces the incidence of complications after thoracic surgery remains unclear. The incidence of postoperative complications was more strongly affected by low pulmonary function than by the duration of preoperative smoking cessation. For patients with marginal indications for surgery, postponing surgery to accommodate a smoking cessation period seemed unnecessary.

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  21. Commentary: Change the temperature before we have to 査読有り

    Kadomatsu Yuka, Chen-Yoshikawa Toyofumi Fengshi

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   164 巻 ( 2 ) 頁: E71 - E72   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Thoracic and Cardiovascular Surgery  

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  22. Postoperative empyema complicated with descending necrotizing fasciitis: a case report

    Kadomatsu Yuka, Ueno Harushi, Goto Masaki, Ozeki Naoki, Nakamura Shota, Chen-Yoshikawa Toyofumi Fengshi

    SURGICAL CASE REPORTS   8 巻 ( 1 ) 頁: 133   2022年7月

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  23. The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study

    Ohashi Mizuki, Miura Katsuyuki, Takashima Naoyuki, Kadota Aya, Saito Yoshino, Tsuji Shunichiro, Murakami Takashi, Kadomatsu Yuka, Nagayoshi Mako, Hara Megumi, Tanaka Keitaro, Tamura Takashi, Hishida Asahi, Takezaki Toshiro, Shimoshikiryo Ippei, Ozaki Etsuko, Watanabe Isao, Suzuki Sadao, Watanabe Miki, Kuriki Kiyonori, Arisawa Kokichi, Katsuura-Kamano Sakurako, Yamasaki Sho, Ikezaki Hiroaki, Oze Isao, Koyanagi Yuriko N., Mikami Haruo, Nakamura Yohko, Takeuchi Kenji, Kita Yoshikuni, Wakai Kenji

    HYPERTENSION RESEARCH   45 巻 ( 4 ) 頁: 708 - 714   2022年4月

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    記述言語:英語   出版者・発行元:Hypertension Research  

    Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status. We evaluated the association of reproductive history with hypertension and obesity using a large cross-sectional dataset from the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). At the baseline survey, physical data, blood samples, and self-reported health questionnaires were collected. Participants with insufficient data were excluded, and 24,558 women from eight study regions were included in this study. Logistic regression analysis was conducted to evaluate the association of reproductive history with hypertension and obesity using multivariable-adjusted odds ratios. In premenopausal women, childbirth showed a generally protective effect on hypertension but not on obesity. In postmenopausal women, childbirth was positively associated with obesity and hypertension but not with hypertension after adjusting for BMI. In conclusion, reproductive history was associated with hypertension and obesity in a large Japanese population, and this association differed between premenopausal and postmenopausal women.

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  24. Risk Assessment for Loss-of-Exercise Capacity After Lung Cancer Surgery: Current Advances in Surgery and Systemic Treatment

    Ozeki Naoki, Kadomatsu Yuka, Mizuno Yota, Inoue Takayuki, Nagaya Motoki, Goto Masaki, Nakamura Shota, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    WORLD JOURNAL OF SURGERY   46 巻 ( 4 ) 頁: 933 - 941   2022年4月

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    記述言語:日本語   出版者・発行元:World Journal of Surgery  

    Background: Considering advances in current post-recurrence treatment, we examined the prognostic significance of the number of risk factors for loss-of-exercise capacity (LEC) after lung cancer surgery, which were identified by our previous prospective observational study. Methods: Risk factors for LEC were defined as a short baseline 6-min walk distance (<400 m), older age (≥75 years), and low predicted postoperative diffusing capacity for carbon monoxide (<60%). Patients were classified as Risk 0/I/II/III according to the number of risk factors. The survival data were retrospectively analyzed. Results: Between 2014 and 2017, 564 patients (n = 307, 193, 57, 7; Risk 0/I/II/III) who underwent lung cancer surgery were included in the study. The number of risk factors was associated with smoking status, predicted postoperative forced expiratory volume in 1 s, histology, pathological stage, and adjuvant therapy. In a multivariate Cox regression analysis, compared to Risk 0, Risk I/II/III showed significant associations with overall survival (hazard ratios: 1.92, 3.35, 9.21; 95% confidence interval: 1.27–2.92, 2.01–5.58, 3.64–23.35; Risk I/II/III, respectively). In 141 patients with recurrence, molecular targeted therapies (MTTs) or immune checkpoint inhibitors (ICIs) were included in 58%, 47%, 32%, and 0% (Risk 0/I/II/III) during the course of treatment. In patients with MTT/ICI treatment, the estimated 1-year and 3-year post-recurrence survival rates were 88% and 58%, respectively. Conclusions: Risk classification for LEC was associated with survival after lung cancer surgery, as well as post-recurrence treatment. The concept of physical performance-preserving surgery may contribute to improving the outcomes of current lung cancer treatment.

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  25. Pleural Invasion Depth of Disseminated Nodules in Patients with Stage IVa or Recurrent Thymoma: Assessment, Curative Impact, and Surgical Outcomes

    Nakamura Shota, Tateyama Hisashi, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Ueno Harushi, Goto Masaki, Ozeki Naoki, Fukui Takayuki, Yokoi Kohei, Chen-Yoshikawa Toyofumi F.

    ANNALS OF SURGICAL ONCOLOGY   29 巻 ( 3 ) 頁: 1829 - 1837   2022年3月

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    記述言語:日本語   出版者・発行元:Annals of Surgical Oncology  

    Background: Thymoma patients with pleural dissemination are difficult to manage, and their treatment strategy remains undefined. This study aimed to investigate the clinicopathologic features of these patients, focusing on the association between the depth of pleural invasion and prognosis. Methods: Between 2003 and 2019, the study identified 120 disseminated lesions in 20 thymoma patients. Seven patients had de novo stage IVa thymoma and 13 were recurrent cases. Extrapleural pneumonectomy was performed for 8 patients and debulking surgery for 12 patients. Invasion depth of pleural tumors was classified into two groups: when the disseminated tumors invaded the pleura beneath the elastic layer, the tumor was diagnosed as Da, and when the disseminated tumors invaded the pleura beyond the elastic layer, the tumor was diagnosed as Db. Results: Of 120 nodules, 31 (26%), found in eight patients with recurrent malignancies, were classified as Db. The pathologic status of the surgical margin (PSM) was positive in eight patients, seven of whom had Db nodules. The 5-year overall survival (OS) rate was 100% in the Da group and 75% in the Db group (P = 0.02). The 5-year progression-free survival (PFS) rate was 66.7% in the Da group and 25% in the Db group (P = 0.02). Cox univariate analysis showed that PFS was significantly influenced by the depth of invasion (P = 0.04) and PSM (P = 0.03). Conclusion: Depth of pleural invasion may influence survival outcomes for thymoma patients with pleural dissemination. The patients in this study with Da-disseminated nodules had an increased probability of a longer OS and PFS and tended to achieve negative PSM compared with the patients with Db.

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  26. ASO Visual Abstract: Pleural Invasion Depth of Disseminated Nodules in Patients with Stage IVa or Recurrent Thymoma: Assessment, Curative Impact, and Surgical Outcomes

    Nakamura Shota, Tateyama Hisashi, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Ueno Harushi, Goto Masaki, Ozeki Naoki, Fukui Takayuki, Yokoi Kohei, Chen-Yoshikawa Toyofumi F.

    ANNALS OF SURGICAL ONCOLOGY   29 巻 ( 3 ) 頁: 1838 - 1838   2022年3月

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    記述言語:日本語   出版者・発行元:Annals of surgical oncology  

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  27. Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study

    Matsunaga Takashi, Kadomatsu Yuka, Tsukamoto Mineko, Kubo Yoko, Okada Rieko, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Takezaki Toshiro, Shimoshikiryo Ippei, Suzuki Sadao, Nakagawa Hiroko, Takashima Naoyuki, Saito Yoshino, Kuriki Kiyonori, Arisawa Kokichi, Katsuura-Kamano Sakurako, Kuriyama Nagato, Matsui Daisuke, Mikami Haruo, Nakamura Yohko, Oze Isao, Ito Hidemi, Murata Masayuki, Ikezaki Hiroaki, Nishida Yuichiro, Shimanoe Chisato, Takeuchi Kenji, Wakai Kenji

    PLOS ONE   17 巻 ( 1 ) 頁: e0262252   2022年1月

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    記述言語:英語   出版者・発行元:PLoS ONE  

    Objective The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. Methods The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Results Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose–response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ?4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ?55 years old. Conclusions Breastfeeding history may be related to lower prevalence of metabolic syndrome in middleaged parous women.

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  28. Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study

    Takeuchi Kenji, Naito Mariko, Kawai Sayo, Tsukamoto Mineko, Kadomatsu Yuka, Kubo Yoko, Okada Rieko, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Nakatochi Masahiro, Sasakabe Tae, Hashimoto Shuji, Eguchi Hidetaka, Momozawa Yukihide, Ikezaki Hiroaki, Murata Masayuki, Furusyo Norihiro, Tanaka Keitaro, Hara Megumi, Nishida Yuichiro, Matsuo Keitaro, Ito Hidemi, Oze Isao, Mikami Haruo, Nakamura Yohko, Kusakabe Miho, Takezaki Toshiro, Ibusuki Rie, Shimoshikiryo Ippei, Suzuki Sadao, Nishiyama Takeshi, Watanabe Miki, Koyama Teruhide, Ozaki Etsuko, Watanabe Isao, Kuriki Kiyonori, Kita Yoshikuni, Ueshima Hirotsugu, Matsui Kenji, Arisawa Kokichi, Uemura Hirokazu, Katsuura-Kamano Sakurako, Nakamura Sho, Narimatsu Hiroto, Hamajima Nobuyuki, Tanaka Hideo, Wakai Kenji

    JOURNAL OF EPIDEMIOLOGY   31 巻 ( 12 ) 頁: 660 - 668   2021年12月

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    記述言語:英語   出版者・発行元:Journal of Epidemiology  

    Background: The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene–environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants. Methods: The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history and collected peripheral blood samples. Results: The baseline survey included 92,610 adults (mean age: 55.2 [standard deviation, 9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65–69 years for men and 60–64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women. Conclusions: The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.

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  29. Multicentre, prospective, observational study investigating the most appropriate surgical option that can prevent the recurrence of primary spontaneous pneumothorax after surgery: the PATCH study, protocol

    Kadomatsu Yuka, Yoshioka Hiromu, Shigemitsu Kikuo, Nomata Yuji, Mori Shunsuke, Hijiya Kyoko, Motoyama Hideki, Ichikawa Yasuhisa, Sueyoshi Kuniyo, Okasaka Toshiki, Miyamoto Ei, Kobayashi Masashi, Takahashi Mamoru, Fujinaga Takuji, Takechi Hiroko, Yamagishi Hiroya, Takuwa Teruhisa, Kobayashi Jun, Sakamoto Jin, Taniguchi Tetsuo, Hanaoka Nobuharu, Kubo Yoko, Chen-Yoshikawa Toyofumi F.

    BMJ OPEN   11 巻 ( 12 ) 頁: e052045   2021年12月

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    記述言語:日本語   出版者・発行元:BMJ Open  

    Introduction Thoracoscopic surgery is performed for refractory or recurrent primary spontaneous pneumothorax (PSP). To reduce postoperative recurrence, additional treatment is occasionally adopted during surgery after bulla resection. However, the most effective method has not been fully elucidated. Furthermore, the preference for additional treatment varies among countries, and its efficacy in preventing recurrence must be evaluated based on settings tailored for the conditions of a specific country. The number of registries collecting detailed data about PSP surgery is limited. Therefore, to address this issue, a prospective multicentre observational study was performed. Methods and analysis This multicentre, prospective, observational study will enrol 450 participants aged between 16 and 40 years who initially underwent PSP surgery. Data about demographic characteristics, disease and family history, surgical details, and CT scan findings will be collected. Follow-up must be conducted until 3 years after surgery or in the event of recurrence, whichever came first. Patients without recurrence will undergo annual follow-up until 3 years after surgery. The primary outcome is the rate of recurrence within 2 years after surgery. A multivariate analysis will be performed to compare the efficacy of different surgical options. Then, adverse outcomes correlated with various treatments and the feasibility of treatment methods will be compared. Ethics and dissemination This study was approved by the local ethics committee of all participating centres. The findings will be available in 2025, and they can be used as a basis for clinical decision-making regarding appropriate options for the initial PSP surgery. Trial registration number NCT04758143.

    DOI: 10.1136/bmjopen-2021-052045

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  30. Removal of hematoma due to massive hemoptysis after transbronchial biopsy: a case report

    Ueno Harushi, Tsubouchi Hideki, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Goto Masaki, Ozeki Naoki, Nakamura Shota, Fukui Takayuki, Chen-Yoshikawa Toyofumi Fengshi

    SURGICAL CASE REPORTS   7 巻 ( 1 ) 頁: 237   2021年11月

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  31. Diagnostic utility of metabolic parameters on FDG PET/CT for lymph node metastasis in patients with cN2 non-small cell lung cancer

    Nakanishi Keita, Nakamura Shota, Sugiyama Tomoshi, Kadomatsu Yuka, Ueno Harushi, Goto Masaki, Ozeki Naoki, Fukui Takayuki, Iwano Shingo, Chen-Yoshikawa Toyofumi Fengshi

    BMC CANCER   21 巻 ( 1 ) 頁: 983   2021年9月

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    記述言語:日本語   出版者・発行元:BMC Cancer  

    Background: The aim of this study was to assess the diagnostic utility of metabolic parameters on fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/computed tomography (CT) for predicting lymph node (LN) metastasis in patients with cN2 non-small cell lung cancer (NSCLC). Methods: We retrospectively reviewed patients who underwent surgery for cN2 NSCLC between 2007 and 2020. Those who had clinically diagnosed positive hilar and mediastinal LNs by routine CT and PET/CT imaging were investigated. To measure the metabolic parameters of LNs, the data according to maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and LN-to-primary tumor ratio of SUVmax (LPR) were examined. The diagnosis of each retrieved LN was confirmed based on histopathological examination of surgical tissue specimens. Receiver operating characteristics (ROC) curves with area under the curve (AUC) calculations and multivariate analysis by logistic regression were performed. Results: Forty-five patients with 84 clinically diagnosed positive hilar or mediastinal LNs were enrolled in the present study. Of the 84 LNs, 63 LNs were pathologically proven as positive (75%). The SUVmax, MTV, TLG, and LPR of LN metastasis were significantly higher than those of benign nodes. In the ROC analysis, the AUC value of LPR [AUC, 0.776; 95% confidence interval (CI), 0.640–0.913] was higher than that of LN SUVmax (AUC, 0.753; 95% CI, 0.626–0.880) or LN TLG3.5 (AUC, 0.746; 95% CI, 0.607–0.885). Using the optimal LPR cutoff value of 0.47, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 84.1, 66.7, 88.3, 58.3, and 79.8%, respectively. Multivariate analysis by logistic regression showed that LPR was an independent predictor for LN metastasis (odds ratio, 6.45; 95% CI, 1.785–23.301; P = 0.004). In the subgroup analysis of adenocarcinoma patients (n = 18; 32 LNs), TLG3.5 was a better predictor (AUC, 0.816; 95% CI, 0.639–0.985) than LPR (AUC, 0.792; 95% CI, 0.599–0.986) or LN SUVmax (AUC, 0.792; 95% CI, 0.625–0.959). Conclusions: Our findings suggest that LPR on FDG-PET is a useful predictor for LN metastasis in patients with cN2 NSCLC. TLG can be a good predictor for LN metastasis in patients with adenocarcinoma.

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  32. Differential impacts of postoperative complications on patients' survival in completely resected non-small-cell lung cancer

    Kadomatsu Yuka, Tsubouchi Hideki, Nakanishi Keita, Sugiyama Tomoshi, Ueno Harushi, Goto Masaki, Ozeki Naoki, Nakamura Shota, Fukui Takayuki, Chen-Yoshikawa Toyofumi Fengshi

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   69 巻 ( 9 ) 頁: 1283 - 1290   2021年9月

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    記述言語:日本語   出版者・発行元:General Thoracic and Cardiovascular Surgery  

    Objective: The aim of this study was to investigate the effects of inflammatory respiratory complications on long-term survival in patients with resected non-small cell lung cancer. We defined inflammatory respiratory complications to include the following six conditions: pneumonia, empyema, bronchial fistula, respiratory dysfunction, acute interstitial pneumonia, and atelectasis. Methods: Part of the National Clinical Database was linked to our prospective database from 2014 to 2017. Linkage was achieved for 866 patients. The Kaplan–Meier method was used to evaluate the overall, relapse-free, and cancer-related survival. The Cox proportional hazard model was used to analyze the impact of each complication. Results: Of the 736 patients included in the study, 149 had complications. The 5-year overall and cancer-specific survival rates were significantly lower in patients with inflammatory respiratory complications. The Cox proportional hazard model showed that the inflammatory respiratory complications had a significant impact on overall survival (hazard ratio 2.48, 95% confidence interval 1.41–4.38) but not air leak (hazard ratio 1.38, 95% confidence interval 0.70–2.70). Conclusions: Our study shows the differential impact of each complication on the survival of patients with non-small cell lung cancer. The presence of inflammatory respiratory complications was the only predictor of poor overall survival.

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  33. A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern 査読有り

    Suzuki Harumitsu, Nakamura Yasuyuki, Matsuo Keitaro, Imaeda Nahomi, Goto Chiho, Narita Akira, Shimizu Atsushi, Takashima Naoyuki, Matsui Kenji, Miura Katsuyuki, Nakatochi Masahiro, Hishida Asahi, Tamura Takashi, Kadomatsu Yuka, Okada Rieko, Nishida Yuichiro, Shimanoe Chisato, Nishimoto Daisaku, Takezaki Toshiro, Oze Isao, Ito Hidemi, Ikezaki Hiroaki, Murata Masayuki, Matsui Daisuke, Ozaki Etsuko, Mikami Haruo, Nakamura Yohko, Suzuki Sadao, Watanabe Miki, Arisawa Kokichi, Uemura Hirokazu, Kuriki Kiyonori, Momozawa Yukihide, Kubo Michiaki, Kita Yoshikuni, Takeuchi Kenji, Wakai Kenji

    EUROPEAN JOURNAL OF CLINICAL NUTRITION   75 巻 ( 6 ) 頁: 937 - 945   2021年6月

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    記述言語:日本語   出版者・発行元:European Journal of Clinical Nutrition  

    Background/Objectives: Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. Subjects/Methods: We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region. Results: We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10−8. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. Conclusion: We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.

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  34. Left brachiocephalic vein aneurysm: a case report

    Ueno Harushi, Yazawa Mari, Tsubouchi Hideki, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Goto Masaki, Ozeki Naoki, Nakamura Shota, Fukui Takayuki, Mutsuga Masato, Yoshikawa Toyofumi Fengshi Chen

    SURGICAL CASE REPORTS   7 巻 ( 1 ) 頁: 66   2021年3月

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  35. Left brachiocephalic vein aneurysm: a case report 査読有り

    Surg Case Rep .     2021年3月

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    記述言語:英語  

    DOI: 10.1186/s40792-021-01148-0.

  36. Polyglycolic acid sheet covering to prevent recurrence after surgery for spontaneous pneumothorax: a meta-analysis 査読有り

    Kadomatsu Yuka, Fukui Takayuki, Mori Shoichi, Chen-Yoshikawa Toyofumi Fengshi, Wakai Kenji

    SCIENTIFIC REPORTS   11 巻 ( 1 ) 頁: 3392   2021年2月

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    記述言語:日本語   出版者・発行元:Scientific Reports  

    The coverage technique using absorbable mesh was first described in a European guideline published in 2015 as a preventive method for the recurrence of spontaneous pneumothorax. We performed a meta-analysis based on a literature search of primary studies that compared the postoperative recurrence rate of primary spontaneous pneumothorax between the use and nonuse of polyglycolic acid sheet coverage. Two reviewers independently selected and evaluated the quality of the relevant studies. The risk ratio in each study was calculated in a random-effect meta-analysis. Statistical heterogeneity among the included studies was quantitatively evaluated using the I2 index, and publication bias was assessed using a funnel plot. A total of 19 retrospective cohort studies were analyzed: 1524 patients who underwent wedge resection alone (the control group) and 1579 who received additional sheet coverage. Polyglycolic acid sheet coverage was associated with a lower recurrence rate than that in the control group (risk ratio: 0.27, 95% confidence interval 0.20–0.37, P < 0.001; I2 0%). The funnel plot suggested possible publication bias. The covering technique reduced the recurrence rate of pneumothorax after thoracoscopic surgery to one-fourth.

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  37. Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study 査読有り

    Hishida Asahi, Nakatochi Masahiro, Tamura Takashi, Nagayoshi Mako, Okada Rieko, Kubo Yoko, Tsukamoto Mineko, Kadomatsu Yuka, Suzuki Sadao, Nishiyama Takeshi, Kuriyama Nagato, Watanabe Isao, Takezaki Toshiro, Nishimoto Daisaku, Kuriki Kiyonori, Arisawa Kokichi, Katsuura-Kamano Sakurako, Mikami Haruo, Kusakabe Miho, Oze Isao, Koyanagi Yuriko N., Nakamura Yasuyuki, Kadota Aya, Shimanoe Chisato, Tanaka Keitaro, Ikezaki Hiroaki, Murata Masayuki, Kubo Michiaki, Momozawa Yukihide, Takeuchi Kenji, Wakai Kenji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 1 ) 頁: 183 - 194   2021年2月

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    記述言語:日本語   出版者・発行元:Nagoya Journal of Medical Science  

    Prostate cancer is emerging as a significant global public health burden. The incidence and prevalence of prostate cancer has increased in Japan, as westernized lifestyles become more popular. Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with serum prostate-specific antigen (PSA) levels. One GWAS, which was based on classic GWAS microarray measurements, has been reported for Japanese so far. In the present study,we conducted a GWAS of serum PSA using 1000Genomes imputed GWAS data (n =1,216) from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, to detect candidate novel genetic loci that influence serum PSA levels in Japanese. The association of SNPs/genetic variants with serum PSA as a continuous variable was tested using the linear Wald test. SNP rs10000006 in SGMS2 (sphingomyelin synthase 2) on chromosome 4 had genome-wide significance (P <5×10∑8), and eight variants on three chromosomes (chromosomes 12, 14, 15) had genome-wide suggestive levels of significance (P <1×10∑6). With an independent data set from the J-MICC Shizuoka Study (n = 2,447), the association of the SGMS2 SNP with blood PSA levels was not replicated. Although our GWAS failed to detect novel loci associated with serum PSA levels in the Japanese cohort, it confirmed the significant effects of previously reported genetic loci on PSA levels in Japanese. Importantly, our results confirmed the significance of KLK3 SNPs also in Japanese, implying that consideration of individual genetic information in prostate cancer diagnosis may be possible in the future.

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  38. Impact of PSCA Polymorphisms on the Risk of Duodenal Ulcer

    Usui Yoshiaki, Matsuo Keitaro, Oze Isao, Ugai Tomotaka, Koyanagi Yuriko, Maeda Yoshinobu, Ito Hidemi, Hishida Asahi, Takeuchi Kenji, Tamura Takashi, Tsukamoto Mineko, Kadomatsu Yuka, Hara Megumi, Nishida Yuichiro, Shimoshikiryo Ippei, Takezaki Toshiro, Ozaki Etsuko, Matsui Daisuke, Watanabe Isao, Suzuki Sadao, Watanabe Miki, Nakagawa-Senda Hiroko, Mikami Haruo, Nakamura Yohko, Arisawa Kokichi, Uemura Hirokazu, Kuriki Kiyonori, Takashima Naoyuki, Kadota Aya, Ikezaki Hiroaki, Murata Masayuki, Nakatochi Masahiro, Momozawa Yukihide, Kubo Michiaki, Wakai Kenji

    JOURNAL OF EPIDEMIOLOGY   31 巻 ( 1 ) 頁: 12 - 20   2021年1月

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    記述言語:英語   出版者・発行元:Journal of Epidemiology  

    Background: While duodenal ulcer (DU) and gastric cancer (GC) are both H. pylori infection-related diseases, individuals withDU are known to have lower risk for GC. Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in PSCA and the risk of DU=GU and evaluate its interaction with environmental factors in a Japanese population. Methods: Six PSCA SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU=GU. Results: PSCA rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18-1.51; P = 2.28 × 10-6) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit, and H. pylori status. On the other hand, we did not observe an association between the risk of GU and PSCA SNPs. Conclusions: Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.

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  39. Prognostic factors of stage I thymic epithelial tumors 査読有り

    Fukui Takayuki, Kadomatsu Yuka, Tsubouchi Hideki, Nakanishi Keita, Ueno Harushi, Sugiyama Tomoshi, Goto Masaki, Ozeki Naoki, Nakamura Shota, Chen-Yoshikawa Toyofumi Fengshi

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   69 巻 ( 1 ) 頁: 59 - 66   2021年1月

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    記述言語:日本語   出版者・発行元:General Thoracic and Cardiovascular Surgery  

    Objective: According to the tumor-node-metastasis classification for thymic malignancies, the proportion of patients diagnosed with stage I is expected to increase significantly. However, whether those patients have homogenous clinicopathological features and survival has not been fully evaluated. Methods: We reviewed 153 consecutive patients with stage I thymic epithelial tumors (133 thymomas, 15 thymic carcinomas, and 5 neuroendocrine tumors) who underwent complete resection at our institution between 2001 and 2016 and evaluated the prognostic significance of their clinicopathological factors. Results: The stage I patients accounted for 78% of all thymic epithelial tumors. The 5-year overall survival and recurrence-free survival rates of the 153 patients were 94% and 80%, respectively. The patients with the histology of thymic carcinoma or neuroendocrine tumor and with a tumor larger than 5.0 cm showed significantly worse recurrence-free survival in multivariate analysis (p = 0.027 and 0.038, respectively). Only the tumor size was revealed as a significant prognostic factor for recurrence-free survival when limited in the 133 cases of thymoma (p = 0.048). Conclusions: Patients with large tumors showed significantly worse recurrence-free survival than those with small tumors both in stage I thymic epithelial tumors and thymomas.

    DOI: 10.1007/s11748-020-01427-x

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  40. 多職種チームで行う「献体を用いた臓器摘出トレーニング」in Clinical Anatomy Laboratory Nagoya (CALNA)

    中村 彰太, 六鹿 雅登, 後藤 和大, 仲西 慶太, 杉山 燈人, 門松 由佳, 上野 陽史, 後藤 真輝, 尾関 直樹, 福本 紘一, 伊藤 英樹, 小山 富生, 碓氷 章彦, 芳川 豊史

    移植   56 巻 ( Supplement ) 頁: s105 - s105   2021年

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    記述言語:日本語   出版者・発行元:一般社団法人 日本移植学会  

    <p>【背景】脳死ドナー臓器摘出では、外科医だけでなく臨床工学技士(ME)・看護師・コーディネーター等多職種が関わる医療で、実際の手技を知っていればよりよい連携が可能かもしれない。献体されたご遺体の固定方法は進化しており、特殊な保存液で固定された状態は生体と類似しているため、手術トレーニングに用いることが可能となった。肺移植実施施設でない当院での実施施設へのとり組みの一貫として、心臓外科医・ME・医学生と合同で臓器摘出トレーニングを実行したので報告する。</p><p>【トレーニング概要】開胸・心嚢切開し臓器評価方法を全員で確認した後、心灌流液注入用と肺灌流液ドレナージ用のカテーテルを各留置し、大血管を遮断し心臓摘出、続いて肺摘出を行った。続いてバックテーブルにて肺の植え込みができる状態にまで処理を行いトレーニング終了とした。心肺摘出に際して重要となる左房の処理については、操作を止め指導医にポイントを解説してもらいつつ、心臓外科・呼吸器外科の双方の考えを伝え、解剖を確認しながら行った。また、MEと肺灌流液ドレナージ経路の方法や肺灌流のタイミングなど細やかな部分まで共有できた。</p><p>【結語】本トレーニングは多職種での手技と順序の確認に有用で、臓器摘出の際互いに心がけているポイントや考えも共有・理解できた。今後はプログラムを定型化し、実践に対応できるレベルに質を高めつつ、看護師やコーディネーターも含めて行う予定である。</p>

    DOI: 10.11386/jst.56.supplement_s105

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  41. Associations between peroxisome proliferator-activated receptor γ (<i>PPAR</i>-γ ) polymorphisms and serum lipids: Two cross-sectional studies of community-dwelling adults 査読有り

    Matsunaga Takashi, Naito Mariko, Yin Guang, Hishida Asahi, Okada Rieko, Kawai Sayo, Sasakabe Tae, Kadomatsu Yuka, Tsukamoto Mineko, Kubo Yoko, Tamura Takashi, Takeuchi Kenji, Mori Atsuyoshi, Hamajima Nobuyuki, Wakai Kenji

    GENE   762 巻   頁: 145019   2020年12月

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    記述言語:英語   出版者・発行元:Gene  

    Dyslipidemia is a well-established risk factor for cardiovascular disease. Experimental studies have reported that peroxisome proliferator-activated receptor γ (PPAR-γ) regulates adipocyte differentiation, lipid storage, and glucose metabolism. Therefore, we examined the associations between PPAR-γ polymorphisms (rs1801282, rs3856806, rs12497191, rs1151999, and rs1152003) and serum lipids in two cross-sectional studies. In the Shizuoka area of the Japan Multi-Institutional Collaborative Cohort Study, we examined 4,952 participants (3,356 men and 1,596 women) in a baseline survey and 2,245 participants (1,550 men and 695 women) in a second survey 5 years later. Outcome measures were the prevalence of dyslipidemia (low-density lipoprotein-cholesterol [LDL-C] ≥ 140 mg/dl, high-density lipoprotein-cholesterol < 40 mg/dl, triglycerides ≥ 150 mg/dl, and/or use of cholesterol-lowering drugs) and the prevalence of high LDL-C (LDL-C ≥ 140 mg/dl and/or use of cholesterol-lowering drugs). Multivariate odds ratios (ORs) were estimated by using unconditional logistic regression models. A total of 2,114 and 1,431 individuals (42.7% and 28.9%) had dyslipidemia and high LDL-C in the baseline survey, respectively, as did 933 and 716 (41.6% and 31.9%), respectively, in the second survey. In the baseline study, compared with major allele homozygotes, minor allele homozygotes of rs3856806 and rs12497191 had a 42% (OR, 0.58; 95% confidence interval (CI), 0.39–0.85) and 23% (OR, 0.77; 95% CI, 0.60–0.99) lower risk of dyslipidemia, respectively, after adjustment for potential confounding factors. In addition, minor allele homozygotes of rs3856806 had a 45% (OR, 0.55; 95% CI, 0.35–0.86) lower risk of high LDL-C. Similar risk reductions were found in the second survey. In conclusion, rs3856806 and rs12497191 polymorphisms may be related to a lower risk of dyslipidemia and high LDL-C.

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  42. Association between plasma levels of homocysteine, folate, and vitamin B<sub>12</sub>, and dietary folate intake and hypertension in a cross-sectional study 査読有り

    Tamura Takashi, Kuriyama Nagato, Koyama Teruhide, Ozaki Etsuko, Matsui Daisuke, Kadomatsu Yuka, Tsukamoto Mineko, Kubo Yoko, Okada Rieko, Hishida Asahi, Sasakabe Tae, Kawai Sayo, Naito Mariko, Takashima Naoyuki, Kadota Aya, Tanaka Keitaro, Hara Megumi, Suzuki Sadao, Nakagawa-Senda Hiroko, Takezaki Toshiro, Shimoshikiryo Ippei, Ikezaki Hiroaki, Murata Masayuki, Oze Isao, Ito Hidemi, Mikami Haruo, Nakamura Yohko, Kuriki Kiyonori, Arisawa Kokichi, Uemura Hirokazu, Takeuchi Kenji, Wakai Kenji

    SCIENTIFIC REPORTS   10 巻 ( 1 ) 頁: 18499   2020年10月

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    記述言語:英語   出版者・発行元:Scientific Reports  

    There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41–3.96) in men and 1.86 (95% CI 1.11–3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.

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  43. Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study 査読有り

    Kenji Takeuchi 1, Mariko Naito 1 2, Sayo Kawai 1 3, Mineko Tsukamoto 1, Yuka Kadomatsu 1, Yoko Kubo 1, Rieko Okada 1, Mako Nagayoshi 1, Takashi Tamura 1, Asahi Hishida 1, Masahiro Nakatochi 4, Tae Sasakabe 1 3, Shuji Hashimoto 5, Hidetaka Eguchi 6, Yukihide Momozawa 7, Hiroaki Ikezaki 8 9, Masayuki Murata 9, Norihiro Furusyo 10, Keitaro Tanaka 11, Megumi Hara 11, Yuichiro Nishida 11, Keitaro Matsuo 12 13, Hidemi Ito 14 15, Isao Oze 12, Haruo Mikami 16, Yohko Nakamura 16, Miho Kusakabe 16, Toshiro Takezaki 17, Rie Ibusuki 17, Ippei Shimoshikiryo 17, Sadao Suzuki 18, Takeshi Nishiyama 18, Miki Watanabe 18, Teruhide Koyama 19, Etsuko Ozaki 19, Isao Watanabe 19, Kiyonori Kuriki 20, Yoshikuni Kita 21, Hirotsugu Ueshima 22, Kenji Matsui 23, Kokichi Arisawa 24, Hirokazu Uemura 24 25, Sakurako Katsuura-Kamano 24, Sho Nakamura 26 27, Hiroto Narimatsu 26 27, Nobuyuki Hamajima 28, Hideo Tanaka 29, Kenji Wakai 1

    J Epidemiol.     2020年9月

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    記述言語:英語  

  44. Current trends in thoracic surgery

    Chen-Yoshikawa Toyofumi F., Fukui Takayuki, Nakamura Shota, Ito Toshinari, Kadomatsu Yuka, Tsubouchi Hideki, Ueno Harushi, Sugiyama Tomoshi, Goto Masaki, Mori Shunsuke, Ozeki Naoki, Hakiri Shuhei, Kawaguchi Koji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   82 巻 ( 2 ) 頁: 161 - 174   2020年5月

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    記述言語:日本語   出版者・発行元:Nagoya Journal of Medical Science  

    Thoracic surgery has evolved drastically in recent years. Although thoracic surgeons mainly deal with tumorous lesion in the lungs, mediastinum, and pleura, they also perform lung transplantation surgery in patients with end-stage lung disease. Herein, we introduce various major current topics in thoracic surgery. Minimally invasive surgical procedures include robot-assisted thoracic surgery and uniportal video-assisted thoracic surgery. Novel techniques for sublobar resection include virtual-assisted lung mapping, imageguided video-assisted thoracic surgery, and segmentectomy using indocyanine green. Three-dimensional (3D) computed tomography (CT) simulation consists of surgeon-friendly 3D-CT image analysis systems and new-generation, dynamic 3D-CT imaging systems. Updates in cadaveric lung transplantation include use of marginal donors, including donation after circulatory death, and ex vivo lung perfusion for such donors. Topics in living donor lobar lung transplantation include size matching, donor issues, and new surgical techniques. During routine clinical practice, thoracic surgeons encounter various pivotal topics related to thoracic surgery, which are described in this report.

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  45. Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study

    Okada Rieko, Kadomatsu Yuka, Tsukamoto Mineko, Sasakabe Tae, Kawai Sayo, Tamura Takashi, Hishida Asahi, Ikezaki Hiroaki, Furusyo Norihiro, Tanaka Keitaro, Hara Megumi, Suzuki Sadao, Watanabe Miki, Takezaki Toshiro, Nishimoto Daisaku, Matsui Daisuke, Watanabe Isao, Kuriki Kiyonori, Takashima Naoyuki, Nakamura Yoshimasa, Katsuura-Kamano Sakurako, Arisawa Kokichi, Mikami Haruo, Nakamura Yoko, Oze Isao, Koyanagi Yuriko N., Naito Mariko Fujimoto, Wakai Kenji

    JOURNAL OF HUMAN HYPERTENSION   34 巻 ( 2 ) 頁: 125 - 131   2020年2月

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    記述言語:日本語   出版者・発行元:Journal of Human Hypertension  

    The aim of this study is to show the combined effect of weight gain within normal weight range in adulthood and parental HT on the prevalence of HT. The study subjects were 44,998 individuals (19,039 men and 25,959 women) with normal weight (body mass index [BMI] 18.5–24.9) aged 35–69 years who participated in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were categorized into six groups by weight gain from age 20 years (<10 kg, and ≥10 kg) and by the number of parents having HT (no parent, one parent, and both parents). Odds ratios for HT were estimated after adjustment for age, sex, current BMI, estimated daily sodium intake, and other confounding factors. The prevalence of HT (31.5% in total subjects) gradually increased with greater weight gain from age 20 years and with greater number of parents with HT. Subjects who gained weight ≥10 kg and having both parents with HT showed the highest risk of having HT compared with those who gained weight <10 kg without parental HT (59.8% vs. 24.9%, odds ratio 4.25, 95% CI 3.53–5.13 after adjustment). This association was similarly observed in any category of age, sex, and BMI. Subjects who gained weight within normal range of BMI and having one or both parent(s) with HT showed the higher risk of having HT independent of their attained BMI in their middle ages. Thus, subjects having parent(s) with HT should avoid gaining their weight during adulthood, even within normal range of BMI, to reduce the risk of having HT.

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  46. Associations between diet and mental health using the 12-item General Health Questionnaire: cross-sectional and prospective analyses from the Japan Multi-Institutional Collaborative Cohort Study

    Choda Naoki, Wakai Kenji, Naito Mariko, Imaeda Nahomi, Goto Chiho, Maruyama Kenta, Kadomatsu Yuka, Tsukamoto Mineko, Sasakabe Tae, Kubo Yoko, Okada Rieko, Kawai Sayo, Tamura Takashi, Hishida Asahi, Takeuchi Kenji, Mori Atsuyoshi, Hamajima Nobuyuki

    NUTRITION JOURNAL   19 巻 ( 1 ) 頁: 2   2020年1月

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    記述言語:日本語   出版者・発行元:Nutrition Journal  

    Background: Mental health has become a major public health issue worldwide. Biological and epidemiological studies suggest diet has a role in the prevention or cure of mental disorders. However, further research is required to elucidate the relationship between diet and mental health. This study aimed to investigate associations between dietary intake of nutrients (macronutrients, vitamins, calcium, and fatty acids) and food groups (fish, meat and chicken, dairy products, and vegetables) and mental health among middle-aged Japanese in cross-sectional and prospective studies. Methods: In total, 9298 men and women that participated in two areas of the Japan Multi-Institutional Collaborative Cohort Study were eligible for analysis at the baseline (cross-sectional) survey. Of these, 4701 participants were followed for about 5 years and included in the follow-up (prospective) analysis. The 12-item General Health Questionnaire (GHQ) was used to assess participants' general mental health status over the past several weeks. The average intake of 46 foods over the past year was assessed by a validated food frequency questionnaire. We also evaluated lifestyle and medical factors using a self-administered questionnaire. A cross-sectional logistic regression analysis was performed to estimate odds ratios for a GHQ score ≥ 4 (poor mental health) according to dietary intake of foods/nutrients at baseline. The prospective study used baseline dietary and lifestyle factors and GHQ scores at follow-up. Results: The cross-sectional logistic regression analysis showed vegetables, protein, calcium, vitamin D, carotene and n-3 highly-polyunsaturated fatty acids were inversely associated with a GHQ score ≥ 4. On the other hand, mono-unsaturated fatty acids showed a positive association with higher GHQ score. The prospective logistic regression analysis found dairy products, calcium, vitamin B2, and saturated fatty acids were inversely correlated with a GHQ score ≥ 4. Calcium was associated with GHQ scores in both the cross-sectional and follow-up studies. In the follow-up study, the multivariable-adjusted odds ratio for a GHQ score ≥ 4 was 0.71 (95% confidence interval, 0.55-0.92) for the highest versus lowest quartiles of calorie-adjusted dietary calcium intake. Conclusion: Consuming particular nutrients and foods, especially calcium and dairy products, may lead to better mental health in Japanese adults.

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  47. The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population[S]

    Nishida Yuichiro, Hachiya Tsuyoshi, Hara Megumi, Shimanoe Chisato, Tanaka Keitaro, Sutoh Yoichi, Shimizu Atsushi, Hishida Asahi, Tsukamoto Mineko, Kadomatsu Yuka, Oze Isao, Koyanagi Yuriko N., Kuriyama Nagato, Koyama Teruhide, Ibusuki Rie, Takezaki Toshiro, Ikezaki Hiroaki, Furusyo Norihiro, Takashima Naoyuki, Kadota Aya, Uemura Hirokazu, Katsuura-Kamano Sakurako, Suzuki Sadao, Nakagawa-Senda Hiroko, Kuriki Kiyonori, Mikami Haruo, Nakamura Yohko, Momozawa Yukihide, Kubo Michiaki, Nakatochi Masahiro, Naito Mariko, Wakai Kenji

    JOURNAL OF LIPID RESEARCH   61 巻 ( 1 ) 頁: 86 - 94   2020年1月

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    記述言語:日本語   出版者・発行元:Journal of Lipid Research  

    Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDLC- related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-Crelated SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β= 0.032) or high PA (β= 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.

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  48. Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study

    Koyama Teruhide, Kuriyama Nagato, Ozaki Etsuko, Tomida Satomi, Uehara Ritei, Nishida Yuichiro, Shimanoe Chisato, Hishida Asahi, Tamura Takashi, Tsukamoto Mineko, Kadomatsu Yuka, Oze Isao, Matsuo Keitaro, Mikami Haruo, Nakamura Yohko, Ibusuki Rie, Takezaki Toshiro, Suzuki Sadao, Nishiyama Takeshi, Kuriki Kiyonori, Takashima Naoyuki, Kadota Aya, Uemura Hirokazu, Katsuura-Kamano Sakurako, Ikezaki Hiroaki, Murata Masayuki, Takeuchi Kenji, Wakai Kenji

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   27 巻 ( 10 ) 頁: 1097 - 1107   2020年

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    記述言語:英語   出版者・発行元:Journal of Atherosclerosis and Thrombosis  

    Aim: Accumulating evidence reveals that sedentary behavior is associated with mortality and cardiometabolic disease; however, there are potential age and sex differences in sedentary behavior and health outcomes that have not been adequately addressed. This study aimed to determine the association of sedentary behavior with cardiometabolic diseases such as hypertension, dyslipidemia, diabetes mellitus, and its risk factors in a large Japanese population according to age and sex. Methods: Using data from the Japan Multi-Institutional Collaborative Cohort Study obtained from baseline surveys, data of 62,754 participants (27,930 males, 34,824 females) were analyzed. This study uses a cross-sectional design and self-administered questionnaires to evaluate sedentary time and anamnesis. For the logistic regression analysis, sedentary time <5 h/day was used as the reference and then adjusted for age, research areas, leisure-time metabolic equivalents, and alcohol and smoking status. From the analysis of anthropometric and blood examinations, 35,973 participants (17,109 males, 18,864 females) were analyzed. Results: For hypertension and diabetes, sedentary time was associated with a significantly higher proportion of male participants. Both sexes were associated with a significantly higher proportion of participants with dyslipidemia. Participants who had longer sedentary time tended to have increased levels of blood pressure, triglycerides, and non-high-density lipoprotein cholesterol (HDL-C), and decreased levels of HDL-C, especially in the 60–69 years group. Conclusions: Independent of leisure-time physical activity, sedentary time was associated with cardiometabolic diseases in a large Japanese population classified by age and sex. Our findings indicate that regularly interrupting and replacing sedentary time may contribute to better physical health-related quality of life.

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  49. A risk score predicting new incidence of hypertension in Japan 査読有り

    Kadomatsu Yuka, Tsukamoto Mineko, Sasakabe Tae, Kawai Sayo, Naito Mariko, Kubo Yoko, Okada Rieko, Tamura Takashi, Hishida Asahi, Mori Atsuyoshi, Hamajima Nobuyuki, Yokoi Kohei, Wakai Kenji

    JOURNAL OF HUMAN HYPERTENSION   33 巻 ( 10 ) 頁: 748 - 755   2019年10月

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    記述言語:日本語   出版者・発行元:Journal of Human Hypertension  

    The prevention of hypertension starts with the awareness of risk. Our aim was to construct a simple and well-validated risk model for nonhypertensive people in Japan consisting of basic clinical variables, using a dataset for two areas derived from the Japan Multi-Institutional Collaborative Cohort Study. We constructed a continuous-value model using data on 5105 subjects participating in both the baseline survey and a second survey conducted after 5 years. The area under the receiver operating characteristic curve (AUC) and the Hosmer–Lemeshow χ2 statistic for the entire cohort were 0.826 and 7.06, respectively. For validation, the entire cohort was randomly divided 100 times into derivation and validation sets at a ratio of 6:4. The summarized median AUC and the Hosmer–Lemeshow χ2 statistic were 0.83 and 12.2, respectively. The AUC of a point-based model consisting of integer scores assigned to each variable was 0.826 and showed no difference, compared with the continuous-value model. This simple risk model may help the general population to assess their risks of new-onset hypertension.

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  50. Frequency of forest walking is not associated with prevalence of hypertension based on cross-sectional studies of a general Japanese population: a reconfirmation by the J-MICC Daiko Study

    Morita Emi, Kadomatsu Yuka, Tsukamoto Mineko, Kubo Yoko, Okada Rieko, Sasakabe Tae, Kawai Sayo, Hishida Asahi, Naito Mariko, Wakai Kenji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   81 巻 ( 3 ) 頁: 489 - 500   2019年8月

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    記述言語:日本語   出版者・発行元:Nagoya Journal of Medical Science  

    Forest walking or Shinrin-yoku is a health promotion activity in Japan. Although some studies have reported the acute effects of walking a few hours in forested areas in reducing blood pressure level compared to other environments, studies investigating whether successive walking has long-term effects in lowering blood pressure levels or lowering prevalence of hypertension are rare. This study aimed to reconfirm the presence or absence of an association between the frequency of forest walking and prevalence of hypertension in a Japanese population. This J-MICC Daiko Study was conducted targeting residents in Nagoya City. A total of 5,109 participants (1,452 men and 3,657 women; age, mean ± standard deviation: 52.5 ± 10.3 years) were included in the analysis. Age-adjusted blood pressure level by frequency of forest walking was not significant. After adjusting for age and lifestyle, the adjusted odds ratios (aORs) of the most frequent group (n=88, 1.7%; once a week or more group) relative to the less than once a month group (n=4,558, 89.2%) for prevalence of hypertension were not also significant [0.80 (95% CI: 0.40-1.62) for men and 1.48 (95% CI: 0.73-3.00) for women]. This study reconfirmed that either lowering blood pressure level or lowering the prevalence of hypertension is not associated with frequency of forest walking, similar to the results of our previous J-MICC Shizuoka Study. Given that these two studies were cross-sectional studies, cohort studies investigating the causal relationship are required to evaluate the effect of frequent forest walking on the prevention of hypertension.

    DOI: 10.18999/nagjms.81.3.489

    Web of Science

    Scopus

    PubMed

  51. Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study

    Iwasaki Yuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Uemura Hirokazu, Tsukamoto Mineko, Kadomatsu Yuka, Okada Rieko, Hishida Asahi, Tanaka Keitaro, Hara Megumi, Takezaki Toshiro, Shimatani Keiichi, Ozaki Etsuko, Koyama Teruhide, Suzuki Sadao, Nakagawa-Senda Hiroko, Kuriki Kiyonori, Miyagawa Naoko, Kadota Aya, Ikezaki Hiroaki, Furusyo Norihiro, Oze Isao, Ito Hidemi, Mikami Haruo, Nakamura Yohko, Wakai Kenji

    NUTRIENTS   11 巻 ( 5 )   2019年5月

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    記述言語:日本語   出版者・発行元:Nutrients  

    The association between nutrient patterns and metabolic syndrome (MetS) has not been examined in a Japanese population. A cross-sectional study was performed on 30,108 participants (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Dietary intake was assessed using a 46-item food frequency questionnaire. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009, using body mass index instead of waist circumference. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and three nutrient patterns were extracted: Factor 1 (fiber, potassium and vitamins pattern); Factor 2 (fats and fat-soluble vitamins pattern); and Factor 3 (saturated fatty acids, calcium and vitamin B2 pattern). In multiple logistic regression analysis adjusted for sex, age, and other potential confounders, Factor 1 scores were associated with a significantly reduced odds ratio (OR) of MetS and all five components. Factor 2 scores were associated with significantly increased prevalence of MetS, obesity, and high blood pressure. Factor 3 scores were significantly associated with lower OR of MetS, high blood pressure, high serum triglycerides and low HDL cholesterol levels. Analysis of nutrient patterns may be useful to assess the overall quality of diet and its association with MetS.

    DOI: 10.3390/nu11050990

    Web of Science

    Scopus

    PubMed

  52. Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study

    Tamura Takashi, Kadomatsu Yuka, Tsukamoto Mineko, Okada Rieko, Sasakabe Tae, Kawai Sayo, Hishida Asahi, Hara Megumi, Tanaka Keitaro, Shimoshikiryo Ippei, Takezaki Toshiro, Watanabe Isao, Matsui Daisuke, Nishiyama Takeshi, Suzuki Sadao, Endoh Kaori, Kuriki Kiyonori, Kita Yoshikuni, Katsuura-Kamano Sakurako, Arisawa Kokichi, Ikezaki Hiroaki, Furusyo Norihiro, Koyanagi Yuriko N., Oze Isao, Nakamura Yohko, Mikami Haruo, Naito Mariko, Wakai Kenji

    MEDICINE   97 巻 ( 48 ) 頁: e13241   2018年11月

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    記述言語:日本語   出版者・発行元:Medicine (United States)  

    Brief exposure to passive smoking immediately elevates blood pressure. However, little is known about the association between exposure to passive smoking and chronic hypertension. We aimed to examine this association in a cross-sectional study, after controlling multiple potential confounders. Participants included 32,098 lifetime nonsmokers (7,216 men and 24,882 women) enrolled in the Japan Multi-Institutional Collaborative Cohort Study. Passive smoking was assessed using a self-administered questionnaire. The single question about exposure to passive smoking had five response options: Ågsometimes or almost never,Åh Ågalmost every day, 2 hours/day or less,Åh Ågalmost every day, 2 to 4 hours/day,Åh Ågalmost every day, 4 to 6 hours/day,Åh and Ågalmost every day, 6 hours/day or longer.Åh Hypertension was defined as any of the following: systolic blood pressure ≥140mmHg, diastolic blood pressure ≥90mmHg, or use of antihypertensive medication. Multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) for hypertension were estimated by exposure level to passive smoking using unconditional logistic regression models. The multivariate-adjusted OR for hypertension in those exposed almost every day was 1.11 (95% CI: 1.03.1.20) compared with those exposed sometimes or almost never. The OR for a 1-hour per day increase in exposure was 1.03 (95% CI: 1.01.1.06, Pfor trend=.006). This association was stronger in men than in women; the ORs were 1.08 (95% CI: 1.01.1.15, Pfor trend=.036) and 1.03 (95% CI: 1.00.1.05, Pfor trend=.055), respectively. Our findings suggest importance of tobacco smoke control for preventing hypertension.

    DOI: 10.1097/MD.0000000000013241

    Web of Science

    Scopus

    PubMed

  53. Comparison of the analgesic effects of modified continuous intercostal block and paravertebral block under surgeon's direct vision after video-assisted thoracic surgery: a randomized clinical trial 査読有り

    Kadomatsu Yuka, Mori Shoichi, Ueno Harushi, Uchiyama Mika, Wakai Kenji

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   66 巻 ( 7 ) 頁: 425 - 431   2018年7月

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    記述言語:日本語   出版者・発行元:General Thoracic and Cardiovascular Surgery  

    Objective: Clinical evidence comparing paravertebral (PVB) and continuous intercostal nerve (ICB) blocks for pain management post video-assisted thoracic surgery (VATS) is limited. This study confirms the analgesic effect of ICB using two catheters is not inferior to that of PVB under direct vision. Methods: Fifty patients who underwent VATS lobectomy from July 2015 to March 2016 were prospectively recruited and randomly assigned to PVB and ICB groups. Postoperative pain was assessed using the visual analog scale (VAS). VAS score at rest at 24 h was the primary endpoint. Data on time required for catheter insertion, adverse effects, and frequency of additional analgesics as secondary endpoints were also collected. Noninferiority was assessed by adding a VAS margin of 15 mm to the PVB group. Results: No significant differences were observed between the VAS scores of the two groups except at 48 h after surgery, with a margin noted for the PVB group. No significant differences were detected in the frequency of additional analgesics and occurrence of adverse effects. Conclusions: Our results could not clearly establish noninferiority of ICB to PVB. Improvements in ICB may be necessary for it to be used as an alternative method to PVB.

    DOI: 10.1007/s11748-018-0936-8

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    Scopus

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  54. 荒蕪肺を伴う続発性気管支動脈蔓状血管腫に対して左肺全摘術を施行した一例

    門松 由佳, 川角 佑太, 上野 陽史, 宇佐 美範恭, 内山 美佳, 森 正一

    日本呼吸器外科学会雑誌   32 巻 ( 4 ) 頁: 458 - 463   2018年5月

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    記述言語:日本語   出版者・発行元:特定非営利活動法人 日本呼吸器外科学会  

    <p>症例は60歳男性.繰り返す喀血を主訴に前医を受診した.重症肺炎の既往があり,左肺機能の低下を指摘されていた.胸部CTで左肺全体の囊胞状変化と容積低下,気管支拡張を認めた.複数の気管支動脈が高度に拡張し大動脈弓下と左肺門部を蛇行していた.標的血管が多く著明な拡張を伴っていたため気管支動脈塞栓術は不可能と判断し手術を施行した.手術は肺動静脈の処理を先行し,異常血管の集簇切離を行うことで時間を短縮し出血を最小限にとどめた.左肺全摘術後,広背筋弁にて気管支断端を被覆した.出血量は1,040 mLであった.術後経過は良好で以降は喀血を認めていない.気管支動脈蔓状血管腫の手術では異常血管の脆弱性と易出血性のため出血コントロールに苦慮する事がある.我々は,手術時の異常血管切離の手順と方法に工夫を加えることで高度に拡張した続発性気管支動脈蔓状血管腫の手術を比較的少ない出血量で手術を終えることができた.</p>

    DOI: 10.2995/jacsurg.32.458

    CiNii Research

  55. 上大静脈および腕頭静脈合併切除を施行した胸部悪性腫瘍症例における血行再建術式と周術期管理の検討

    門松 由佳, 森 正一, 上野 陽史, 福本 紘一, 内山 美佳, 重光 希公生, 吉岡 洋, 横井 香平

    日本呼吸器外科学会雑誌   31 巻 ( 4 ) 頁: 446 - 452   2017年

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    記述言語:日本語   出版者・発行元:特定非営利活動法人 日本呼吸器外科学会  

    <p>目的:呼吸器外科手術において上大静脈や腕頭静脈の合併切除と血行再建を行った症例について,手術方法,周術期管理および再建血管の開存性について検討した.</p><p>方法:2005年から2014年までに上大静脈および腕頭静脈の切除と再建を施行した15例を対象とした.患者背景,再建術式,使用した人工血管の種類,抗凝固療法および再建血管の閉塞の有無および閉塞時の症状等を調査した.</p><p>結果:対象疾患は胸腺上皮性腫瘍11例,胚細胞性腫瘍2例,肺癌・悪性リンパ腫各1例で,切除した血管は上大静脈13例,右腕頭静脈12例,左腕頭静脈14例であった.全例で,血行再建には径10 mm以上の人工血管が使用され,周術期に抗凝固療法が行われていた.再建血管の閉塞が確認されたのは6例で,左右腕頭静脈再建例では人工血管閉塞時の症状出現が少なかった.</p><p>結論:大血管の切除を伴う手術は現在においても困難な術式であるが,今回検討した症例では周術期死亡や術後急性期の人工血管閉塞は認められなかった.また,人工血管閉塞に伴う症状が出現しない場合には血管閉塞時にも経過観察が可能であると考えられた.</p>

    DOI: 10.2995/jacsurg.31.446

    CiNii Research

▼全件表示

講演・口頭発表等 3

  1. Resection Process Mapの術中使用経験

    門松 由佳1、中尾  恵2、勝谷亮太郎1、岡戸 翔嗣1、伊藤 俊成1、佐藤 惠雄1、仲西 慶太1、上野 陽史1、加藤 毅人1、尾関 直樹1、中村 彰太1、福本 紘一1、芳川 豊史1

    第65回関西胸部外科学会学術集会  2022年6月17日 

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    開催年月日: 2022年6月

    記述言語:日本語   会議種別:口頭発表(一般)  

    開催地:浜松  

  2. 日本から世界へ提案する「気胸手術の人工物による被覆法」

    門松 由佳 1、吉岡 洋 2、岡阪 敏樹 3、重光 希公生 4、大政貢 5、奥村 典仁 6、森 正一 7、藤永 卓司 8、山岸 弘哉 9、石田 順造 10、土屋 恭子 11、成田 久仁夫 12、末吉 国誉 13、中川 達雄 14、青山 晃博 15、中村 彰太 1、長井 信二郎 16、多久和 輝尚 17、小林 淳 18、阪井 宏彰 19、阪本 仁 20、花 岡 伸治 21、黄 政龍 22、芳川 豊史 1

    第122回日本外科学会定期学術集会  2022年4月14日 

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    開催年月日: 2022年4月

    記述言語:日本語  

    開催地:熊本  

  3. 原発性自然気胸におけるPGAシートの断端被覆の再発予防効果 メタアナリシス

    門松由佳

    第120回 日本外科学会  2020年8月13日  日本外科学会

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    開催年月日: 2020年8月

    記述言語:日本語   会議種別:ポスター発表  

    開催地:横浜  

科研費 2

  1. オリガミ理論に基づいた正確な肺部分切除法の創出

    研究課題/研究課題番号:22K16565  2022年4月 - 2025年3月

    科学研究費助成事業  若手研究

    門松 由佳

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    担当区分:研究代表者 

    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

    CT機器の精度向上と普及に伴い微小肺結節の切除手術は増加している。部分切除時の肺は肺の虚脱(脱気変形)のみならず、肺の折りたたみ(Folding)による修飾をうける。様々な微小結節位置の同定法が考案されているが、いずれも微小結節の表面位置の指標のみであり、深部断端の特定法はいまだ確立されていない。今なお、非触知結節の深部断端は外科医の経験にもとづいて予測し、切除している現状がある。本研究が目指すのは術前CTのみから肺部分切除時(脱気変形+Folding変形後)の位置同定アルゴリズムを確立することである。

  2. 脱気変形アルゴリズムとバードビュー機能を用いた肺表面位置情報ガイドの開発への挑戦

    研究課題/研究課題番号:21H03020  2021年4月 - 2024年3月

    科学研究費助成事業  基盤研究(B)

    芳川 豊史, 北坂 孝幸, 中尾 恵, 中村 彰太, 門松 由佳, 後藤 真輝

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    担当区分:研究分担者 

    肺は、術前CT画像は含気状態であるが、手術は脱気状態で行われるため、術前と術中の形態が大きく異なる。
    画像技術の進歩により、微小な肺結節の検出が増え、その切除には、術前マーキングが必須である。また、区域切除において、現在行われている区域間面の同定法も確実とはいえず、現在の内視鏡カメラでは視野に限界がある。
    本研究では, 侵襲的な処置をすることなく、真に低侵襲に微小肺結節を切除するために、微小結節の位置や区域間面の同定が正確に可能となるシステムを情報学的手法により構築する。また、バードビューカメラシステムを用い、肺表面の位置情報を術中にリアルタイムで、わかりやすく、正確にガイドすることを目指す。

 

担当経験のある科目 (本学) 1

  1. 4年生臨床医学総論PBLチュートリアル

    2022

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    4年生臨床医学総論PBLチュートリアル

 

メディア報道 1

  1. ポリグリコール酸シート貼付による自然気胸の術後再発予防効果の検証 ~日本から世界へ発信する気胸の術後再発予防法~ インターネットメディア

    日本の研究.com  2021年3月

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    執筆者:本人 

    本研究の成果から、貼付法が自然気胸の術後再発予防に効果的である可能性と、今後は大規模な前向き研究が真の効果判定に必要であることがわかりました。今後は、国内のみではなく世界でも貼付法が研究され、より多くの気胸患者さんの治療に役立つことを願っています。

    本研究成果は、2021 年 2 月 9 日付国際科学雑誌「Scientific Reports」に 掲載されました。