Updated on 2022/03/25

写真a

 
KADOMATSU Yuka
 
Organization
Nagoya University Hospital Thoracic Surgery Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. Doctor of Medical Science ( 2021.3   Nagoya University ) 

Research Areas 1

  1. Life Science / Respiratory surgery  / Primary spontaneous pneumothorax, lung cancer

Research History 1

  1. Nagoya University   Assistant professor of hospital

    2020.4

Education 2

  1. Nagoya University

    2017.4 - 2021.3

  2. Nagoya University   Faculty of medicine   Department of Medicine

    2002.4 - 2008.3

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    Country: Japan

 

Papers 37

  1. Differential impacts of postoperative complications on patients' survival in completely resected non-small-cell lung cancer Reviewed

    Yuka Kadomatsu, Hideki Tsubouchi, Keita Nakanishi, Tomoshi Sugiyama, Harushi Ueno, Masaki Goto, Naoki Ozeki, Shota Nakamura, Takayuki Fukui, Toyofumi Fengshi Chen-Yoshikawa

    Gen Thorac Cardiovasc Surg .     2021.3

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    DOI: 10.1007/s11748-021-01619-z.

  2. Risk Assessment for Loss-of-Exercise Capacity After Lung Cancer Surgery: Current Advances in Surgery and Systemic Treatment

    Ozeki Naoki, Kadomatsu Yuka, Mizuno Yota, Inoue Takayuki, Nagaya Motoki, Goto Masaki, Nakamura Shota, Fukumoto Koichi, Chen-Yoshikawa Toyofumi Fengshi

    WORLD JOURNAL OF SURGERY   Vol. 46 ( 4 ) page: 933 - 941   2022.4

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    Language:Japanese   Publisher:World Journal of Surgery  

    Background: Considering advances in current post-recurrence treatment, we examined the prognostic significance of the number of risk factors for loss-of-exercise capacity (LEC) after lung cancer surgery, which were identified by our previous prospective observational study. Methods: Risk factors for LEC were defined as a short baseline 6-min walk distance (<400 m), older age (≥75 years), and low predicted postoperative diffusing capacity for carbon monoxide (<60%). Patients were classified as Risk 0/I/II/III according to the number of risk factors. The survival data were retrospectively analyzed. Results: Between 2014 and 2017, 564 patients (n = 307, 193, 57, 7; Risk 0/I/II/III) who underwent lung cancer surgery were included in the study. The number of risk factors was associated with smoking status, predicted postoperative forced expiratory volume in 1 s, histology, pathological stage, and adjuvant therapy. In a multivariate Cox regression analysis, compared to Risk 0, Risk I/II/III showed significant associations with overall survival (hazard ratios: 1.92, 3.35, 9.21; 95% confidence interval: 1.27–2.92, 2.01–5.58, 3.64–23.35; Risk I/II/III, respectively). In 141 patients with recurrence, molecular targeted therapies (MTTs) or immune checkpoint inhibitors (ICIs) were included in 58%, 47%, 32%, and 0% (Risk 0/I/II/III) during the course of treatment. In patients with MTT/ICI treatment, the estimated 1-year and 3-year post-recurrence survival rates were 88% and 58%, respectively. Conclusions: Risk classification for LEC was associated with survival after lung cancer surgery, as well as post-recurrence treatment. The concept of physical performance-preserving surgery may contribute to improving the outcomes of current lung cancer treatment.

    DOI: 10.1007/s00268-021-06427-3

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  3. Relationship of smoking cessation period with the incidence of complications in lung cancer surgery.

    Kadomatsu Y, Sugiyama T, Sato K, Nakanishi K, Ueno H, Goto M, Ozeki N, Nakamura S, Fukumoto K, Chen-Yoshikawa TF

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     2022.3

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    Language:English  

    DOI: 10.1093/ejcts/ezac163

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  4. Pleural Invasion Depth of Disseminated Nodules in Patients with Stage IVa or Recurrent Thymoma: Assessment, Curative Impact, and Surgical Outcomes

    Nakamura Shota, Tateyama Hisashi, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Ueno Harushi, Goto Masaki, Ozeki Naoki, Fukui Takayuki, Yokoi Kohei, Chen-Yoshikawa Toyofumi F.

    ANNALS OF SURGICAL ONCOLOGY   Vol. 29 ( 3 ) page: 1829 - 1837   2022.3

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    Language:Japanese   Publisher:Annals of Surgical Oncology  

    Background: Thymoma patients with pleural dissemination are difficult to manage, and their treatment strategy remains undefined. This study aimed to investigate the clinicopathologic features of these patients, focusing on the association between the depth of pleural invasion and prognosis. Methods: Between 2003 and 2019, the study identified 120 disseminated lesions in 20 thymoma patients. Seven patients had de novo stage IVa thymoma and 13 were recurrent cases. Extrapleural pneumonectomy was performed for 8 patients and debulking surgery for 12 patients. Invasion depth of pleural tumors was classified into two groups: when the disseminated tumors invaded the pleura beneath the elastic layer, the tumor was diagnosed as Da, and when the disseminated tumors invaded the pleura beyond the elastic layer, the tumor was diagnosed as Db. Results: Of 120 nodules, 31 (26%), found in eight patients with recurrent malignancies, were classified as Db. The pathologic status of the surgical margin (PSM) was positive in eight patients, seven of whom had Db nodules. The 5-year overall survival (OS) rate was 100% in the Da group and 75% in the Db group (P = 0.02). The 5-year progression-free survival (PFS) rate was 66.7% in the Da group and 25% in the Db group (P = 0.02). Cox univariate analysis showed that PFS was significantly influenced by the depth of invasion (P = 0.04) and PSM (P = 0.03). Conclusion: Depth of pleural invasion may influence survival outcomes for thymoma patients with pleural dissemination. The patients in this study with Da-disseminated nodules had an increased probability of a longer OS and PFS and tended to achieve negative PSM compared with the patients with Db.

    DOI: 10.1245/s10434-021-10888-0

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  5. ASO Visual Abstract: Pleural Invasion Depth of Disseminated Nodules in Patients with Stage IVa or Recurrent Thymoma: Assessment, Curative Impact, and Surgical Outcomes

    Nakamura Shota, Tateyama Hisashi, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Ueno Harushi, Goto Masaki, Ozeki Naoki, Fukui Takayuki, Yokoi Kohei, Chen-Yoshikawa Toyofumi F.

    ANNALS OF SURGICAL ONCOLOGY   Vol. 29 ( 3 ) page: 1838 - 1838   2022.3

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    Language:Japanese   Publisher:Annals of surgical oncology  

    DOI: 10.1245/s10434-021-10969-0

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  6. The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study

    Ohashi Mizuki, Miura Katsuyuki, Takashima Naoyuki, Kadota Aya, Saito Yoshino, Tsuji Shunichiro, Murakami Takashi, Kadomatsu Yuka, Nagayoshi Mako, Hara Megumi, Tanaka Keitaro, Tamura Takashi, Hishida Asahi, Takezaki Toshiro, Shimoshikiryo Ippei, Ozaki Etsuko, Watanabe Isao, Suzuki Sadao, Watanabe Miki, Kuriki Kiyonori, Arisawa Kokichi, Katsuura-Kamano Sakurako, Yamasaki Sho, Ikezaki Hiroaki, Oze Isao, Koyanagi Yuriko N., Mikami Haruo, Nakamura Yohko, Takeuchi Kenji, Kita Yoshikuni, Wakai Kenji

    HYPERTENSION RESEARCH   Vol. 45 ( 4 ) page: 708 - 714   2022.1

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    Language:Japanese   Publisher:Hypertension Research  

    Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status. We evaluated the association of reproductive history with hypertension and obesity using a large cross-sectional dataset from the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). At the baseline survey, physical data, blood samples, and self-reported health questionnaires were collected. Participants with insufficient data were excluded, and 24,558 women from eight study regions were included in this study. Logistic regression analysis was conducted to evaluate the association of reproductive history with hypertension and obesity using multivariable-adjusted odds ratios. In premenopausal women, childbirth showed a generally protective effect on hypertension but not on obesity. In postmenopausal women, childbirth was positively associated with obesity and hypertension but not with hypertension after adjusting for BMI. In conclusion, reproductive history was associated with hypertension and obesity in a large Japanese population, and this association differed between premenopausal and postmenopausal women.

    DOI: 10.1038/s41440-021-00820-0

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  7. Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study.

    Matsunaga T, Kadomatsu Y, Tsukamoto M, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Takezaki T, Shimoshikiryo I, Suzuki S, Nakagawa H, Takashima N, Saito Y, Kuriki K, Arisawa K, Katsuura-Kamano S, Kuriyama N, Matsui D, Mikami H, Nakamura Y, Oze I, Ito H, Murata M, Ikezaki H, Nishida Y, Shimanoe C, Takeuchi K, Wakai K

    PloS one   Vol. 17 ( 1 ) page: e0262252   2022

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    Objective The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. Methods The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Results Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose–response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ?4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ?55 years old. Conclusions Breastfeeding history may be related to lower prevalence of metabolic syndrome in middleaged parous women.

    DOI: 10.1371/journal.pone.0262252

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  8. Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study

    Takeuchi Kenji, Naito Mariko, Kawai Sayo, Tsukamoto Mineko, Kadomatsu Yuka, Kubo Yoko, Okada Rieko, Nagayoshi Mako, Tamura Takashi, Hishida Asahi, Nakatochi Masahiro, Sasakabe Tae, Hashimoto Shuji, Eguchi Hidetaka, Momozawa Yukihide, Ikezaki Hiroaki, Murata Masayuki, Furusyo Norihiro, Tanaka Keitaro, Hara Megumi, Nishida Yuichiro, Matsuo Keitaro, Ito Hidemi, Oze Isao, Mikami Haruo, Nakamura Yohko, Kusakabe Miho, Takezaki Toshiro, Ibusuki Rie, Shimoshikiryo Ippei, Suzuki Sadao, Nishiyama Takeshi, Watanabe Miki, Koyama Teruhide, Ozaki Etsuko, Watanabe Isao, Kuriki Kiyonori, Kita Yoshikuni, Ueshima Hirotsugu, Matsui Kenji, Arisawa Kokichi, Uemura Hirokazu, Katsuura-Kamano Sakurako, Nakamura Sho, Narimatsu Hiroto, Hamajima Nobuyuki, Tanaka Hideo, Wakai Kenji

    Journal of Epidemiology   Vol. 31 ( 12 ) page: 660 - 668   2021.12

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    Language:Japanese   Publisher:Japan Epidemiological Association  

    <p><b>Background:</b> The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene–environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants.</p><p><b>Methods:</b> The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history and collected peripheral blood samples.</p><p><b>Results:</b> The baseline survey included 92,610 adults (mean age: 55.2 [standard deviation, 9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65–69 years for men and 60–64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women.</p><p><b>Conclusions:</b> The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.</p>

    DOI: 10.2188/jea.JE20200147

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  9. Multicentre, prospective, observational study investigating the most appropriate surgical option that can prevent the recurrence of primary spontaneous pneumothorax after surgery: the PATCH study, protocol

    Kadomatsu Yuka, Yoshioka Hiromu, Shigemitsu Kikuo, Nomata Yuji, Mori Shunsuke, Hijiya Kyoko, Motoyama Hideki, Ichikawa Yasuhisa, Sueyoshi Kuniyo, Okasaka Toshiki, Miyamoto Ei, Kobayashi Masashi, Takahashi Mamoru, Fujinaga Takuji, Takechi Hiroko, Yamagishi Hiroya, Takuwa Teruhisa, Kobayashi Jun, Sakamoto Jin, Taniguchi Tetsuo, Hanaoka Nobuharu, Kubo Yoko, Chen-Yoshikawa Toyofumi F.

    BMJ OPEN   Vol. 11 ( 12 ) page: e052045   2021.12

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    Introduction Thoracoscopic surgery is performed for refractory or recurrent primary spontaneous pneumothorax (PSP). To reduce postoperative recurrence, additional treatment is occasionally adopted during surgery after bulla resection. However, the most effective method has not been fully elucidated. Furthermore, the preference for additional treatment varies among countries, and its efficacy in preventing recurrence must be evaluated based on settings tailored for the conditions of a specific country. The number of registries collecting detailed data about PSP surgery is limited. Therefore, to address this issue, a prospective multicentre observational study was performed. Methods and analysis This multicentre, prospective, observational study will enrol 450 participants aged between 16 and 40 years who initially underwent PSP surgery. Data about demographic characteristics, disease and family history, surgical details, and CT scan findings will be collected. Follow-up must be conducted until 3 years after surgery or in the event of recurrence, whichever came first. Patients without recurrence will undergo annual follow-up until 3 years after surgery. The primary outcome is the rate of recurrence within 2 years after surgery. A multivariate analysis will be performed to compare the efficacy of different surgical options. Then, adverse outcomes correlated with various treatments and the feasibility of treatment methods will be compared. Ethics and dissemination This study was approved by the local ethics committee of all participating centres. The findings will be available in 2025, and they can be used as a basis for clinical decision-making regarding appropriate options for the initial PSP surgery. Trial registration number NCT04758143.

    DOI: 10.1136/bmjopen-2021-052045

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  10. Removal of hematoma due to massive hemoptysis after transbronchial biopsy: a case report

    Ueno Harushi, Tsubouchi Hideki, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Goto Masaki, Ozeki Naoki, Nakamura Shota, Fukui Takayuki, Chen-Yoshikawa Toyofumi Fengshi

    SURGICAL CASE REPORTS   Vol. 7 ( 1 ) page: 237   2021.11

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  11. Moderate-to-vigorous Physical Activity and Sedentary Behavior Are Independently Associated With Renal Function: A Cross-sectional Study

    Hara Megumi, Nishida Yuichiro, Tanaka Keitaro, Shimanoe Chisato, Koga Kayoko, Furukawa Takuma, Higaki Yasuki, Shinchi Koichi, Ikezaki Hiroaki, Murata Masayuki, Takeuchi Kenji, Tamura Takashi, Hishida Asahi, Tsukamoto Mineko, Kadomatsu Yuka, Matsuo Keitaro, Oze Isao, Mikami Haruo, Kusakabe Miho, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Nakagawa-Senda Hiroko, Matsui Daisuke, Koyama Teruhide, Kuriki Kiyonori, Takashima Naoyuki, Nakamura Yasuyuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Wakai Kenji

    Journal of Epidemiology   Vol. advpub ( 0 )   2021.10

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    <p><b>Background:</b> Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and chronic kidney disease (CKD), whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function.</p><p><b>Methods:</b> We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR <60 mL/min/1.73 m<sup>2</sup>. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied.</p><p><b>Results:</b> After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (<i>P</i> for trend MVPA <0.0001) and lower eGFR (<i>P</i> for trend SB <0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA ≥20 MET·h/day, 0.76; 95% confidence interval [CI], 0.68–0.85 compared to MVPA <5 MET·h/day) and a higher OR of CKD (adjusted OR of SB ≥16 h/day, 1.81; 95% CI, 1.52–2.15 compared to SB <7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD.</p><p><b>Conclusions:</b> These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.</p>

    DOI: 10.2188/jea.JE20210155

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  12. Diagnostic utility of metabolic parameters on FDG PET/CT for lymph node metastasis in patients with cN2 non-small cell lung cancer

    Nakanishi Keita, Nakamura Shota, Sugiyama Tomoshi, Kadomatsu Yuka, Ueno Harushi, Goto Masaki, Ozeki Naoki, Fukui Takayuki, Iwano Shingo, Chen-Yoshikawa Toyofumi Fengshi

    BMC CANCER   Vol. 21 ( 1 ) page: 983   2021.9

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    Background: The aim of this study was to assess the diagnostic utility of metabolic parameters on fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/computed tomography (CT) for predicting lymph node (LN) metastasis in patients with cN2 non-small cell lung cancer (NSCLC). Methods: We retrospectively reviewed patients who underwent surgery for cN2 NSCLC between 2007 and 2020. Those who had clinically diagnosed positive hilar and mediastinal LNs by routine CT and PET/CT imaging were investigated. To measure the metabolic parameters of LNs, the data according to maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and LN-to-primary tumor ratio of SUVmax (LPR) were examined. The diagnosis of each retrieved LN was confirmed based on histopathological examination of surgical tissue specimens. Receiver operating characteristics (ROC) curves with area under the curve (AUC) calculations and multivariate analysis by logistic regression were performed. Results: Forty-five patients with 84 clinically diagnosed positive hilar or mediastinal LNs were enrolled in the present study. Of the 84 LNs, 63 LNs were pathologically proven as positive (75%). The SUVmax, MTV, TLG, and LPR of LN metastasis were significantly higher than those of benign nodes. In the ROC analysis, the AUC value of LPR [AUC, 0.776; 95% confidence interval (CI), 0.640–0.913] was higher than that of LN SUVmax (AUC, 0.753; 95% CI, 0.626–0.880) or LN TLG3.5 (AUC, 0.746; 95% CI, 0.607–0.885). Using the optimal LPR cutoff value of 0.47, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 84.1, 66.7, 88.3, 58.3, and 79.8%, respectively. Multivariate analysis by logistic regression showed that LPR was an independent predictor for LN metastasis (odds ratio, 6.45; 95% CI, 1.785–23.301; P = 0.004). In the subgroup analysis of adenocarcinoma patients (n = 18; 32 LNs), TLG3.5 was a better predictor (AUC, 0.816; 95% CI, 0.639–0.985) than LPR (AUC, 0.792; 95% CI, 0.599–0.986) or LN SUVmax (AUC, 0.792; 95% CI, 0.625–0.959). Conclusions: Our findings suggest that LPR on FDG-PET is a useful predictor for LN metastasis in patients with cN2 NSCLC. TLG can be a good predictor for LN metastasis in patients with adenocarcinoma.

    DOI: 10.1186/s12885-021-08688-6

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  13. Differential impacts of postoperative complications on patients' survival in completely resected non-small-cell lung cancer

    Kadomatsu Yuka, Tsubouchi Hideki, Nakanishi Keita, Sugiyama Tomoshi, Ueno Harushi, Goto Masaki, Ozeki Naoki, Nakamura Shota, Fukui Takayuki, Chen-Yoshikawa Toyofumi Fengshi

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 69 ( 9 ) page: 1283 - 1290   2021.9

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    Objective: The aim of this study was to investigate the effects of inflammatory respiratory complications on long-term survival in patients with resected non-small cell lung cancer. We defined inflammatory respiratory complications to include the following six conditions: pneumonia, empyema, bronchial fistula, respiratory dysfunction, acute interstitial pneumonia, and atelectasis. Methods: Part of the National Clinical Database was linked to our prospective database from 2014 to 2017. Linkage was achieved for 866 patients. The Kaplan–Meier method was used to evaluate the overall, relapse-free, and cancer-related survival. The Cox proportional hazard model was used to analyze the impact of each complication. Results: Of the 736 patients included in the study, 149 had complications. The 5-year overall and cancer-specific survival rates were significantly lower in patients with inflammatory respiratory complications. The Cox proportional hazard model showed that the inflammatory respiratory complications had a significant impact on overall survival (hazard ratio 2.48, 95% confidence interval 1.41–4.38) but not air leak (hazard ratio 1.38, 95% confidence interval 0.70–2.70). Conclusions: Our study shows the differential impact of each complication on the survival of patients with non-small cell lung cancer. The presence of inflammatory respiratory complications was the only predictor of poor overall survival.

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  14. Prognostic Value of Uncertain Resection for Overall Survival in Non-small Cell Lung Cancer.

    Kadomatsu Y, Nakamura S, Ueno H, Goto M, Ozeki N, Fukumoto K, Fukui T, Suzuki Y, Chen-Yoshikawa TF

    The Annals of thoracic surgery     2021.8

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    Background: In this study we evaluated the R(un) category proposed by the International Association for the Study of Lung Cancer (IASLC) for non-small cell lung cancer (NSCLC). Methods: We retrospectively reviewed the medical records of patients with NSCLC who underwent segmentectomy or lobectomy between 2014 and 2015 at our institution. Residual tumor (R) status was reclassified from the Union for International Cancer Control designation to the IASLC-proposed R classification of R0 and R(un). The underlying reasons for the R(un) reclassification were analyzed according to pathologic stage, lymph node status, and resected lobe. A Cox proportional hazard model was used to evaluate the impacts of R(un) categorization on overall survival. Results: Of 355 patients, 44.5% were reclassified as R(un). The most common reason for the reclassification was insufficient number of harvested lymph nodes or no station 7 lymph nodes. When stratified by tumor location, the absence of station 7 lymph nodes was especially prominent in both the right and left upper lung resections. In the multivariate Cox regression model, the IASLC R classification was associated with poor overall survival in node-positive patients (hazard ratio, 2.657; P =.016). Conclusions: Various factors resulted in reclassification to R(un) because the R(un) group was highly heterogeneous. Careful consideration is required to determine whether the R(un) classification can be used as an indicator of lymph node dissection quality. For advanced cases, the R(un) definition may be useful in predicting poor prognosis.

    DOI: 10.1016/j.athoracsur.2021.07.087

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  15. A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern Reviewed

    Suzuki Harumitsu, Nakamura Yasuyuki, Matsuo Keitaro, Imaeda Nahomi, Goto Chiho, Narita Akira, Shimizu Atsushi, Takashima Naoyuki, Matsui Kenji, Miura Katsuyuki, Nakatochi Masahiro, Hishida Asahi, Tamura Takashi, Kadomatsu Yuka, Okada Rieko, Nishida Yuichiro, Shimanoe Chisato, Nishimoto Daisaku, Takezaki Toshiro, Oze Isao, Ito Hidemi, Ikezaki Hiroaki, Murata Masayuki, Matsui Daisuke, Ozaki Etsuko, Mikami Haruo, Nakamura Yohko, Suzuki Sadao, Watanabe Miki, Arisawa Kokichi, Uemura Hirokazu, Kuriki Kiyonori, Momozawa Yukihide, Kubo Michiaki, Kita Yoshikuni, Takeuchi Kenji, Wakai Kenji

    EUROPEAN JOURNAL OF CLINICAL NUTRITION   Vol. 75 ( 6 ) page: 937 - 945   2021.6

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    Language:Japanese   Publisher:European Journal of Clinical Nutrition  

    Background/Objectives: Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. Subjects/Methods: We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region. Results: We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10−8. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. Conclusion: We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.

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  16. Left brachiocephalic vein aneurysm: a case report

    Ueno Harushi, Yazawa Mari, Tsubouchi Hideki, Nakanishi Keita, Sugiyama Tomoshi, Kadomatsu Yuka, Goto Masaki, Ozeki Naoki, Nakamura Shota, Fukui Takayuki, Mutsuga Masato, Yoshikawa Toyofumi Fengshi Chen

    SURGICAL CASE REPORTS   Vol. 7 ( 1 ) page: 66   2021.3

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  17. Left brachiocephalic vein aneurysm: a case report Reviewed

    Surg Case Rep .     2021.3

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    DOI: 10.1186/s40792-021-01148-0.

  18. Polyglycolic acid sheet covering to prevent recurrence after surgery for spontaneous pneumothorax: a meta-analysis Reviewed

    Kadomatsu Yuka, Fukui Takayuki, Mori Shoichi, Chen-Yoshikawa Toyofumi Fengshi, Wakai Kenji

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 3392   2021.2

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    The coverage technique using absorbable mesh was first described in a European guideline published in 2015 as a preventive method for the recurrence of spontaneous pneumothorax. We performed a meta-analysis based on a literature search of primary studies that compared the postoperative recurrence rate of primary spontaneous pneumothorax between the use and nonuse of polyglycolic acid sheet coverage. Two reviewers independently selected and evaluated the quality of the relevant studies. The risk ratio in each study was calculated in a random-effect meta-analysis. Statistical heterogeneity among the included studies was quantitatively evaluated using the I2 index, and publication bias was assessed using a funnel plot. A total of 19 retrospective cohort studies were analyzed: 1524 patients who underwent wedge resection alone (the control group) and 1579 who received additional sheet coverage. Polyglycolic acid sheet coverage was associated with a lower recurrence rate than that in the control group (risk ratio: 0.27, 95% confidence interval 0.20–0.37, P < 0.001; I2 0%). The funnel plot suggested possible publication bias. The covering technique reduced the recurrence rate of pneumothorax after thoracoscopic surgery to one-fourth.

    DOI: 10.1038/s41598-021-83103-5

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  19. Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study Reviewed

    Hishida Asahi, Nakatochi Masahiro, Tamura Takashi, Nagayoshi Mako, Okada Rieko, Kubo Yoko, Tsukamoto Mineko, Kadomatsu Yuka, Suzuki Sadao, Nishiyama Takeshi, Kuriyama Nagato, Watanabe Isao, Takezaki Toshiro, Nishimoto Daisaku, Kuriki Kiyonori, Arisawa Kokichi, Katsuura-Kamano Sakurako, Mikami Haruo, Kusakabe Miho, Oze Isao, Koyanagi Yuriko N., Nakamura Yasuyuki, Kadota Aya, Shimanoe Chisato, Tanaka Keitaro, Ikezaki Hiroaki, Murata Masayuki, Kubo Michiaki, Momozawa Yukihide, Takeuchi Kenji, Wakai Kenji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 1 ) page: 183 - 194   2021.2

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    Prostate cancer is emerging as a significant global public health burden. The incidence and prevalence of prostate cancer has increased in Japan, as westernized lifestyles become more popular. Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with serum prostate-specific antigen (PSA) levels. One GWAS, which was based on classic GWAS microarray measurements, has been reported for Japanese so far. In the present study,we conducted a GWAS of serum PSA using 1000Genomes imputed GWAS data (n =1,216) from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, to detect candidate novel genetic loci that influence serum PSA levels in Japanese. The association of SNPs/genetic variants with serum PSA as a continuous variable was tested using the linear Wald test. SNP rs10000006 in SGMS2 (sphingomyelin synthase 2) on chromosome 4 had genome-wide significance (P <5×10∑8), and eight variants on three chromosomes (chromosomes 12, 14, 15) had genome-wide suggestive levels of significance (P <1×10∑6). With an independent data set from the J-MICC Shizuoka Study (n = 2,447), the association of the SGMS2 SNP with blood PSA levels was not replicated. Although our GWAS failed to detect novel loci associated with serum PSA levels in the Japanese cohort, it confirmed the significant effects of previously reported genetic loci on PSA levels in Japanese. Importantly, our results confirmed the significance of KLK3 SNPs also in Japanese, implying that consideration of individual genetic information in prostate cancer diagnosis may be possible in the future.

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  20. Commentary: Change the temperature before we have to. Reviewed

    Kadomatsu Y, Chen-Yoshikawa TF

    The Journal of thoracic and cardiovascular surgery     2021.1

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  21. Impact of <i>PSCA</i> Polymorphisms on the Risk of Duodenal Ulcer

    Usui Yoshiaki, Matsuo Keitaro, Oze Isao, Ugai Tomotaka, Koyanagi Yuriko, Maeda Yoshinobu, Ito Hidemi, Hishida Asahi, Takeuchi Kenji, Tamura Takashi, Tsukamoto Mineko, Kadomatsu Yuka, Hara Megumi, Nishida Yuichiro, Shimoshikiryo Ippei, Takezaki Toshiro, Ozaki Etsuko, Matsui Daisuke, Watanabe Isao, Suzuki Sadao, Watanabe Miki, Nakagawa-Senda Hiroko, Mikami Haruo, Nakamura Yohko, Arisawa Kokichi, Uemura Hirokazu, Kuriki Kiyonori, Takashima Naoyuki, Kadota Aya, Ikezaki Hiroaki, Murata Masayuki, Nakatochi Masahiro, Momozawa Yukihide, Kubo Michiaki, Wakai Kenji

    Journal of Epidemiology   Vol. 31 ( 1 ) page: 12 - 20   2021.1

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    <p><b>Background:</b> While duodenal ulcer (DU) and gastric cancer (GC) are both <i>H. pylori</i> infection-related diseases, individuals with DU are known to have lower risk for GC. Many epidemiological studies have identified the <i>PSCA</i> rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). Following these initial reports, however, few studies have since validated these associations. Here, we aimed to validate the association between variations in <i>PSCA</i> and the risk of DU/GU and evaluate its interaction with environmental factors in a Japanese population.</p><p><b>Methods:</b> Six <i>PSCA</i> SNPs were genotyped in 584 DU cases, 925 GU cases, and 8,105 controls from the Japan Multi-Institutional Collaborative Cohort (J-MICC). Unconditional logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between the SNPs and risk of DU/GU.</p><p><b>Results:</b> <i>PSCA</i> rs2294008 C-allele was associated with per allele OR of 1.34 (95% CI, 1.18–1.51; <i>P</i> = 2.28 × 10<sup>−6</sup>) for the risk of DU. This association was independent of age, sex, study site, smoking habit, drinking habit, and <i>H. pylori</i> status. On the other hand, we did not observe an association between the risk of GU and <i>PSCA</i> SNPs.</p><p><b>Conclusions:</b> Our study confirms an association between the <i>PSCA</i> rs2294008 C-allele and the risk of DU in a Japanese population.</p>

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  22. Prognostic factors of stage I thymic epithelial tumors Reviewed

    Fukui Takayuki, Kadomatsu Yuka, Tsubouchi Hideki, Nakanishi Keita, Ueno Harushi, Sugiyama Tomoshi, Goto Masaki, Ozeki Naoki, Nakamura Shota, Chen-Yoshikawa Toyofumi Fengshi

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 69 ( 1 ) page: 59 - 66   2021.1

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    Objective: According to the tumor-node-metastasis classification for thymic malignancies, the proportion of patients diagnosed with stage I is expected to increase significantly. However, whether those patients have homogenous clinicopathological features and survival has not been fully evaluated. Methods: We reviewed 153 consecutive patients with stage I thymic epithelial tumors (133 thymomas, 15 thymic carcinomas, and 5 neuroendocrine tumors) who underwent complete resection at our institution between 2001 and 2016 and evaluated the prognostic significance of their clinicopathological factors. Results: The stage I patients accounted for 78% of all thymic epithelial tumors. The 5-year overall survival and recurrence-free survival rates of the 153 patients were 94% and 80%, respectively. The patients with the histology of thymic carcinoma or neuroendocrine tumor and with a tumor larger than 5.0 cm showed significantly worse recurrence-free survival in multivariate analysis (p = 0.027 and 0.038, respectively). Only the tumor size was revealed as a significant prognostic factor for recurrence-free survival when limited in the 133 cases of thymoma (p = 0.048). Conclusions: Patients with large tumors showed significantly worse recurrence-free survival than those with small tumors both in stage I thymic epithelial tumors and thymomas.

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  23. Associations between peroxisome proliferator-activated receptor gamma (PPAR-gamma ) polymorphisms and serum lipids: Two cross-sectional studies of community-dwelling adults Reviewed

    Matsunaga Takashi, Naito Mariko, Yin Guang, Hishida Asahi, Okada Rieko, Kawai Sayo, Sasakabe Tae, Kadomatsu Yuka, Tsukamoto Mineko, Kubo Yoko, Tamura Takashi, Takeuchi Kenji, Mori Atsuyoshi, Hamajima Nobuyuki, Wakai Kenji

    GENE   Vol. 762   page: 145019   2020.12

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    Dyslipidemia is a well-established risk factor for cardiovascular disease. Experimental studies have reported that peroxisome proliferator-activated receptor γ (PPAR-γ) regulates adipocyte differentiation, lipid storage, and glucose metabolism. Therefore, we examined the associations between PPAR-γ polymorphisms (rs1801282, rs3856806, rs12497191, rs1151999, and rs1152003) and serum lipids in two cross-sectional studies. In the Shizuoka area of the Japan Multi-Institutional Collaborative Cohort Study, we examined 4,952 participants (3,356 men and 1,596 women) in a baseline survey and 2,245 participants (1,550 men and 695 women) in a second survey 5 years later. Outcome measures were the prevalence of dyslipidemia (low-density lipoprotein-cholesterol [LDL-C] ≥ 140 mg/dl, high-density lipoprotein-cholesterol < 40 mg/dl, triglycerides ≥ 150 mg/dl, and/or use of cholesterol-lowering drugs) and the prevalence of high LDL-C (LDL-C ≥ 140 mg/dl and/or use of cholesterol-lowering drugs). Multivariate odds ratios (ORs) were estimated by using unconditional logistic regression models. A total of 2,114 and 1,431 individuals (42.7% and 28.9%) had dyslipidemia and high LDL-C in the baseline survey, respectively, as did 933 and 716 (41.6% and 31.9%), respectively, in the second survey. In the baseline study, compared with major allele homozygotes, minor allele homozygotes of rs3856806 and rs12497191 had a 42% (OR, 0.58; 95% confidence interval (CI), 0.39–0.85) and 23% (OR, 0.77; 95% CI, 0.60–0.99) lower risk of dyslipidemia, respectively, after adjustment for potential confounding factors. In addition, minor allele homozygotes of rs3856806 had a 45% (OR, 0.55; 95% CI, 0.35–0.86) lower risk of high LDL-C. Similar risk reductions were found in the second survey. In conclusion, rs3856806 and rs12497191 polymorphisms may be related to a lower risk of dyslipidemia and high LDL-C.

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  24. Association between plasma levels of homocysteine, folate, and vitamin B-12, and dietary folate intake and hypertension in a cross-sectional study Reviewed

    Tamura Takashi, Kuriyama Nagato, Koyama Teruhide, Ozaki Etsuko, Matsui Daisuke, Kadomatsu Yuka, Tsukamoto Mineko, Kubo Yoko, Okada Rieko, Hishida Asahi, Sasakabe Tae, Kawai Sayo, Naito Mariko, Takashima Naoyuki, Kadota Aya, Tanaka Keitaro, Hara Megumi, Suzuki Sadao, Nakagawa-Senda Hiroko, Takezaki Toshiro, Shimoshikiryo Ippei, Ikezaki Hiroaki, Murata Masayuki, Oze Isao, Ito Hidemi, Mikami Haruo, Nakamura Yohko, Kuriki Kiyonori, Arisawa Kokichi, Uemura Hirokazu, Takeuchi Kenji, Wakai Kenji

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 18499   2020.10

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    There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41–3.96) in men and 1.86 (95% CI 1.11–3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.

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  25. Study profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study Reviewed

    Kenji Takeuchi 1, Mariko Naito 1 2, Sayo Kawai 1 3, Mineko Tsukamoto 1, Yuka Kadomatsu 1, Yoko Kubo 1, Rieko Okada 1, Mako Nagayoshi 1, Takashi Tamura 1, Asahi Hishida 1, Masahiro Nakatochi 4, Tae Sasakabe 1 3, Shuji Hashimoto 5, Hidetaka Eguchi 6, Yukihide Momozawa 7, Hiroaki Ikezaki 8 9, Masayuki Murata 9, Norihiro Furusyo 10, Keitaro Tanaka 11, Megumi Hara 11, Yuichiro Nishida 11, Keitaro Matsuo 12 13, Hidemi Ito 14 15, Isao Oze 12, Haruo Mikami 16, Yohko Nakamura 16, Miho Kusakabe 16, Toshiro Takezaki 17, Rie Ibusuki 17, Ippei Shimoshikiryo 17, Sadao Suzuki 18, Takeshi Nishiyama 18, Miki Watanabe 18, Teruhide Koyama 19, Etsuko Ozaki 19, Isao Watanabe 19, Kiyonori Kuriki 20, Yoshikuni Kita 21, Hirotsugu Ueshima 22, Kenji Matsui 23, Kokichi Arisawa 24, Hirokazu Uemura 24 25, Sakurako Katsuura-Kamano 24, Sho Nakamura 26 27, Hiroto Narimatsu 26 27, Nobuyuki Hamajima 28, Hideo Tanaka 29, Kenji Wakai 1

    J Epidemiol.     2020.9

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  26. Current trends in thoracic surgery

    Chen-Yoshikawa Toyofumi F., Fukui Takayuki, Nakamura Shota, Ito Toshinari, Kadomatsu Yuka, Tsubouchi Hideki, Ueno Harushi, Sugiyama Tomoshi, Goto Masaki, Mori Shunsuke, Ozeki Naoki, Hakiri Shuhei, Kawaguchi Koji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 2 ) page: 161 - 174   2020.5

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    Thoracic surgery has evolved drastically in recent years. Although thoracic surgeons mainly deal with tumorous lesion in the lungs, mediastinum, and pleura, they also perform lung transplantation surgery in patients with end-stage lung disease. Herein, we introduce various major current topics in thoracic surgery. Minimally invasive surgical procedures include robot-assisted thoracic surgery and uniportal video-assisted thoracic surgery. Novel techniques for sublobar resection include virtual-assisted lung mapping, imageguided video-assisted thoracic surgery, and segmentectomy using indocyanine green. Three-dimensional (3D) computed tomography (CT) simulation consists of surgeon-friendly 3D-CT image analysis systems and new-generation, dynamic 3D-CT imaging systems. Updates in cadaveric lung transplantation include use of marginal donors, including donation after circulatory death, and ex vivo lung perfusion for such donors. Topics in living donor lobar lung transplantation include size matching, donor issues, and new surgical techniques. During routine clinical practice, thoracic surgeons encounter various pivotal topics related to thoracic surgery, which are described in this report.

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  27. Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study

    Okada Rieko, Kadomatsu Yuka, Tsukamoto Mineko, Sasakabe Tae, Kawai Sayo, Tamura Takashi, Hishida Asahi, Ikezaki Hiroaki, Furusyo Norihiro, Tanaka Keitaro, Hara Megumi, Suzuki Sadao, Watanabe Miki, Takezaki Toshiro, Nishimoto Daisaku, Matsui Daisuke, Watanabe Isao, Kuriki Kiyonori, Takashima Naoyuki, Nakamura Yoshimasa, Katsuura-Kamano Sakurako, Arisawa Kokichi, Mikami Haruo, Nakamura Yoko, Oze Isao, Koyanagi Yuriko N., Naito Mariko Fujimoto, Wakai Kenji

    JOURNAL OF HUMAN HYPERTENSION   Vol. 34 ( 2 ) page: 125 - 131   2020.2

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    The aim of this study is to show the combined effect of weight gain within normal weight range in adulthood and parental HT on the prevalence of HT. The study subjects were 44,998 individuals (19,039 men and 25,959 women) with normal weight (body mass index [BMI] 18.5–24.9) aged 35–69 years who participated in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were categorized into six groups by weight gain from age 20 years (<10 kg, and ≥10 kg) and by the number of parents having HT (no parent, one parent, and both parents). Odds ratios for HT were estimated after adjustment for age, sex, current BMI, estimated daily sodium intake, and other confounding factors. The prevalence of HT (31.5% in total subjects) gradually increased with greater weight gain from age 20 years and with greater number of parents with HT. Subjects who gained weight ≥10 kg and having both parents with HT showed the highest risk of having HT compared with those who gained weight <10 kg without parental HT (59.8% vs. 24.9%, odds ratio 4.25, 95% CI 3.53–5.13 after adjustment). This association was similarly observed in any category of age, sex, and BMI. Subjects who gained weight within normal range of BMI and having one or both parent(s) with HT showed the higher risk of having HT independent of their attained BMI in their middle ages. Thus, subjects having parent(s) with HT should avoid gaining their weight during adulthood, even within normal range of BMI, to reduce the risk of having HT.

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  28. Associations between diet and mental health using the 12-item General Health Questionnaire: cross-sectional and prospective analyses from the Japan Multi-Institutional Collaborative Cohort Study

    Choda Naoki, Wakai Kenji, Naito Mariko, Imaeda Nahomi, Goto Chiho, Maruyama Kenta, Kadomatsu Yuka, Tsukamoto Mineko, Sasakabe Tae, Kubo Yoko, Okada Rieko, Kawai Sayo, Tamura Takashi, Hishida Asahi, Takeuchi Kenji, Mori Atsuyoshi, Hamajima Nobuyuki

    NUTRITION JOURNAL   Vol. 19 ( 1 ) page: 2   2020.1

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    Background: Mental health has become a major public health issue worldwide. Biological and epidemiological studies suggest diet has a role in the prevention or cure of mental disorders. However, further research is required to elucidate the relationship between diet and mental health. This study aimed to investigate associations between dietary intake of nutrients (macronutrients, vitamins, calcium, and fatty acids) and food groups (fish, meat and chicken, dairy products, and vegetables) and mental health among middle-aged Japanese in cross-sectional and prospective studies. Methods: In total, 9298 men and women that participated in two areas of the Japan Multi-Institutional Collaborative Cohort Study were eligible for analysis at the baseline (cross-sectional) survey. Of these, 4701 participants were followed for about 5 years and included in the follow-up (prospective) analysis. The 12-item General Health Questionnaire (GHQ) was used to assess participants' general mental health status over the past several weeks. The average intake of 46 foods over the past year was assessed by a validated food frequency questionnaire. We also evaluated lifestyle and medical factors using a self-administered questionnaire. A cross-sectional logistic regression analysis was performed to estimate odds ratios for a GHQ score ≥ 4 (poor mental health) according to dietary intake of foods/nutrients at baseline. The prospective study used baseline dietary and lifestyle factors and GHQ scores at follow-up. Results: The cross-sectional logistic regression analysis showed vegetables, protein, calcium, vitamin D, carotene and n-3 highly-polyunsaturated fatty acids were inversely associated with a GHQ score ≥ 4. On the other hand, mono-unsaturated fatty acids showed a positive association with higher GHQ score. The prospective logistic regression analysis found dairy products, calcium, vitamin B2, and saturated fatty acids were inversely correlated with a GHQ score ≥ 4. Calcium was associated with GHQ scores in both the cross-sectional and follow-up studies. In the follow-up study, the multivariable-adjusted odds ratio for a GHQ score ≥ 4 was 0.71 (95% confidence interval, 0.55-0.92) for the highest versus lowest quartiles of calorie-adjusted dietary calcium intake. Conclusion: Consuming particular nutrients and foods, especially calcium and dairy products, may lead to better mental health in Japanese adults.

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  29. The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population[S]

    Nishida Yuichiro, Hachiya Tsuyoshi, Hara Megumi, Shimanoe Chisato, Tanaka Keitaro, Sutoh Yoichi, Shimizu Atsushi, Hishida Asahi, Tsukamoto Mineko, Kadomatsu Yuka, Oze Isao, Koyanagi Yuriko N., Kuriyama Nagato, Koyama Teruhide, Ibusuki Rie, Takezaki Toshiro, Ikezaki Hiroaki, Furusyo Norihiro, Takashima Naoyuki, Kadota Aya, Uemura Hirokazu, Katsuura-Kamano Sakurako, Suzuki Sadao, Nakagawa-Senda Hiroko, Kuriki Kiyonori, Mikami Haruo, Nakamura Yohko, Momozawa Yukihide, Kubo Michiaki, Nakatochi Masahiro, Naito Mariko, Wakai Kenji

    JOURNAL OF LIPID RESEARCH   Vol. 61 ( 1 ) page: 86 - 94   2020.1

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    Few studies have investigated the interactions between HDL-C-related SNPs identified by genome-wide association (GWA) study and physical activity (PA) on HDL-C. First, we conducted a sex-stratified GWA study in a discovery sample (2,231 men and 2,431 women) and replication sample (2,599 men and 3,109 women) to identify SNPs influencing log-transformed HDL-C in Japanese participants in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. We also replicated previously reported HDLC- related SNPs in a combined (discovery plus replication) sample (4,830 men and 5,540 women). We then analyzed the interactions of the HDL-C-related SNPs with PA on HDL-C. The sex-stratified GWA analyses identified 11 and 10 HDL-Crelated SNPs in men and women as targets for an interaction analysis. Among these, only one interaction of ABCA1 rs1883025 with PA was statistically significant in men, after Bonferroni correction [P-interaction = 0.001 (α = 0.05/21 = 0.002)]. The per-major-allele (C allele) increase in log-transformed HDL-C was lost in men with low PA (β = 0.008) compared with those with medium (β= 0.032) or high PA (β= 0.034). These findings suggest that the benefit of carrying a C allele of ABCA1 rs1883025 on enhancing HDL-C may be attenuated in inactive men.

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  30. Sedentary Time is Associated with Cardiometabolic Diseases in A Large Japanese Population: A Cross-Sectional Study

    Koyama Teruhide, Kuriyama Nagato, Ozaki Etsuko, Tomida Satomi, Uehara Ritei, Nishida Yuichiro, Shimanoe Chisato, Hishida Asahi, Tamura Takashi, Tsukamoto Mineko, Kadomatsu Yuka, Oze Isao, Matsuo Keitaro, Mikami Haruo, Nakamura Yohko, Ibusuki Rie, Takezaki Toshiro, Suzuki Sadao, Nishiyama Takeshi, Kuriki Kiyonori, Takashima Naoyuki, Kadota Aya, Uemura Hirokazu, Katsuura-Kamano Sakurako, Ikezaki Hiroaki, Murata Masayuki, Takeuchi Kenji, Wakai Kenji, for the Japan Multi-institutional Collaborative Cohort (J-MICC) Study Group

    Journal of Atherosclerosis and Thrombosis   Vol. 27 ( 10 ) page: 1097 - 1107   2020

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    <p><b>Aim: </b>Accumulating evidence reveals that sedentary behavior is associated with mortality and cardiometabolic disease; however, there are potential age and sex differences in sedentary behavior and health outcomes that have not been adequately addressed. This study aimed to determine the association of sedentary behavior with cardiometabolic diseases such as hypertension, dyslipidemia, diabetes mellitus, and its risk factors in a large Japanese population according to age and sex.<b> </b></p><p><b>Methods: </b>Using data from the Japan Multi-Institutional Collaborative Cohort Study obtained from baseline surveys, data of 62,754 participants (27,930 males, 34,824 females) were analyzed. This study uses a cross-sectional design and self-administered questionnaires to evaluate sedentary time and anamnesis. For the logistic regression analysis, sedentary time <5 h/day was used as the reference and then adjusted for age, research areas, leisure-time metabolic equivalents, and alcohol and smoking status. From the analysis of anthropometric and blood examinations, 35,973 participants (17,109 males, 18,864 females) were analyzed.<b> </b></p><p><b>Results: </b>For hypertension and diabetes, sedentary time was associated with a significantly higher proportion of male participants. Both sexes were associated with a significantly higher proportion of participants with dyslipidemia. Participants who had longer sedentary time tended to have increased levels of blood pressure, triglycerides, and non-high-density lipoprotein cholesterol (HDL-C), and decreased levels of HDL-C, especially in the 60–69 years group.<b> </b></p><p><b>Conclusions: </b>Independent of leisure-time physical activity, sedentary time was associated with cardiometabolic diseases in a large Japanese population classified by age and sex. Our findings indicate that regularly interrupting and replacing sedentary time may contribute to better physical health-related quality of life.</p>

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  31. A risk score predicting new incidence of hypertension in Japan Reviewed

    Kadomatsu Yuka, Tsukamoto Mineko, Sasakabe Tae, Kawai Sayo, Naito Mariko, Kubo Yoko, Okada Rieko, Tamura Takashi, Hishida Asahi, Mori Atsuyoshi, Hamajima Nobuyuki, Yokoi Kohei, Wakai Kenji

    JOURNAL OF HUMAN HYPERTENSION   Vol. 33 ( 10 ) page: 748 - 755   2019.10

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    The prevention of hypertension starts with the awareness of risk. Our aim was to construct a simple and well-validated risk model for nonhypertensive people in Japan consisting of basic clinical variables, using a dataset for two areas derived from the Japan Multi-Institutional Collaborative Cohort Study. We constructed a continuous-value model using data on 5105 subjects participating in both the baseline survey and a second survey conducted after 5 years. The area under the receiver operating characteristic curve (AUC) and the Hosmer–Lemeshow χ2 statistic for the entire cohort were 0.826 and 7.06, respectively. For validation, the entire cohort was randomly divided 100 times into derivation and validation sets at a ratio of 6:4. The summarized median AUC and the Hosmer–Lemeshow χ2 statistic were 0.83 and 12.2, respectively. The AUC of a point-based model consisting of integer scores assigned to each variable was 0.826 and showed no difference, compared with the continuous-value model. This simple risk model may help the general population to assess their risks of new-onset hypertension.

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  32. Frequency of forest walking is not associated with prevalence of hypertension based on cross-sectional studies of a general Japanese population: a reconfirmation by the J-MICC Daiko Study

    Morita Emi, Kadomatsu Yuka, Tsukamoto Mineko, Kubo Yoko, Okada Rieko, Sasakabe Tae, Kawai Sayo, Hishida Asahi, Naito Mariko, Wakai Kenji

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 3 ) page: 489 - 500   2019.8

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    Forest walking or Shinrin-yoku is a health promotion activity in Japan. Although some studies have reported the acute effects of walking a few hours in forested areas in reducing blood pressure level compared to other environments, studies investigating whether successive walking has long-term effects in lowering blood pressure levels or lowering prevalence of hypertension are rare. This study aimed to reconfirm the presence or absence of an association between the frequency of forest walking and prevalence of hypertension in a Japanese population. This J-MICC Daiko Study was conducted targeting residents in Nagoya City. A total of 5,109 participants (1,452 men and 3,657 women; age, mean ± standard deviation: 52.5 ± 10.3 years) were included in the analysis. Age-adjusted blood pressure level by frequency of forest walking was not significant. After adjusting for age and lifestyle, the adjusted odds ratios (aORs) of the most frequent group (n=88, 1.7%; once a week or more group) relative to the less than once a month group (n=4,558, 89.2%) for prevalence of hypertension were not also significant [0.80 (95% CI: 0.40-1.62) for men and 1.48 (95% CI: 0.73-3.00) for women]. This study reconfirmed that either lowering blood pressure level or lowering the prevalence of hypertension is not associated with frequency of forest walking, similar to the results of our previous J-MICC Shizuoka Study. Given that these two studies were cross-sectional studies, cohort studies investigating the causal relationship are required to evaluate the effect of frequent forest walking on the prevention of hypertension.

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  33. Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study

    Iwasaki Yuki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Uemura Hirokazu, Tsukamoto Mineko, Kadomatsu Yuka, Okada Rieko, Hishida Asahi, Tanaka Keitaro, Hara Megumi, Takezaki Toshiro, Shimatani Keiichi, Ozaki Etsuko, Koyama Teruhide, Suzuki Sadao, Nakagawa-Senda Hiroko, Kuriki Kiyonori, Miyagawa Naoko, Kadota Aya, Ikezaki Hiroaki, Furusyo Norihiro, Oze Isao, Ito Hidemi, Mikami Haruo, Nakamura Yohko, Wakai Kenji

    NUTRIENTS   Vol. 11 ( 5 )   2019.5

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    The association between nutrient patterns and metabolic syndrome (MetS) has not been examined in a Japanese population. A cross-sectional study was performed on 30,108 participants (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Dietary intake was assessed using a 46-item food frequency questionnaire. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009, using body mass index instead of waist circumference. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and three nutrient patterns were extracted: Factor 1 (fiber, potassium and vitamins pattern); Factor 2 (fats and fat-soluble vitamins pattern); and Factor 3 (saturated fatty acids, calcium and vitamin B2 pattern). In multiple logistic regression analysis adjusted for sex, age, and other potential confounders, Factor 1 scores were associated with a significantly reduced odds ratio (OR) of MetS and all five components. Factor 2 scores were associated with significantly increased prevalence of MetS, obesity, and high blood pressure. Factor 3 scores were significantly associated with lower OR of MetS, high blood pressure, high serum triglycerides and low HDL cholesterol levels. Analysis of nutrient patterns may be useful to assess the overall quality of diet and its association with MetS.

    DOI: 10.3390/nu11050990

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    PubMed

  34. Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study

    Tamura Takashi, Kadomatsu Yuka, Tsukamoto Mineko, Okada Rieko, Sasakabe Tae, Kawai Sayo, Hishida Asahi, Hara Megumi, Tanaka Keitaro, Shimoshikiryo Ippei, Takezaki Toshiro, Watanabe Isao, Matsui Daisuke, Nishiyama Takeshi, Suzuki Sadao, Endoh Kaori, Kuriki Kiyonori, Kita Yoshikuni, Katsuura-Kamano Sakurako, Arisawa Kokichi, Ikezaki Hiroaki, Furusyo Norihiro, Koyanagi Yuriko N., Oze Isao, Nakamura Yohko, Mikami Haruo, Naito Mariko, Wakai Kenji

    MEDICINE   Vol. 97 ( 48 ) page: e13241   2018.11

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    Language:Japanese   Publisher:Medicine (United States)  

    Brief exposure to passive smoking immediately elevates blood pressure. However, little is known about the association between exposure to passive smoking and chronic hypertension. We aimed to examine this association in a cross-sectional study, after controlling multiple potential confounders. Participants included 32,098 lifetime nonsmokers (7,216 men and 24,882 women) enrolled in the Japan Multi-Institutional Collaborative Cohort Study. Passive smoking was assessed using a self-administered questionnaire. The single question about exposure to passive smoking had five response options: Ågsometimes or almost never,Åh Ågalmost every day, 2 hours/day or less,Åh Ågalmost every day, 2 to 4 hours/day,Åh Ågalmost every day, 4 to 6 hours/day,Åh and Ågalmost every day, 6 hours/day or longer.Åh Hypertension was defined as any of the following: systolic blood pressure ≥140mmHg, diastolic blood pressure ≥90mmHg, or use of antihypertensive medication. Multivariate-adjusted odds ratio (OR) and 95% confidence interval (CI) for hypertension were estimated by exposure level to passive smoking using unconditional logistic regression models. The multivariate-adjusted OR for hypertension in those exposed almost every day was 1.11 (95% CI: 1.03.1.20) compared with those exposed sometimes or almost never. The OR for a 1-hour per day increase in exposure was 1.03 (95% CI: 1.01.1.06, Pfor trend=.006). This association was stronger in men than in women; the ORs were 1.08 (95% CI: 1.01.1.15, Pfor trend=.036) and 1.03 (95% CI: 1.00.1.05, Pfor trend=.055), respectively. Our findings suggest importance of tobacco smoke control for preventing hypertension.

    DOI: 10.1097/MD.0000000000013241

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  35. Comparison of the analgesic effects of modified continuous intercostal block and paravertebral block under surgeon's direct vision after video-assisted thoracic surgery: a randomized clinical trial Reviewed

    Kadomatsu Yuka, Mori Shoichi, Ueno Harushi, Uchiyama Mika, Wakai Kenji

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 66 ( 7 ) page: 425 - 431   2018.7

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    Language:Japanese   Publisher:General Thoracic and Cardiovascular Surgery  

    Objective: Clinical evidence comparing paravertebral (PVB) and continuous intercostal nerve (ICB) blocks for pain management post video-assisted thoracic surgery (VATS) is limited. This study confirms the analgesic effect of ICB using two catheters is not inferior to that of PVB under direct vision. Methods: Fifty patients who underwent VATS lobectomy from July 2015 to March 2016 were prospectively recruited and randomly assigned to PVB and ICB groups. Postoperative pain was assessed using the visual analog scale (VAS). VAS score at rest at 24 h was the primary endpoint. Data on time required for catheter insertion, adverse effects, and frequency of additional analgesics as secondary endpoints were also collected. Noninferiority was assessed by adding a VAS margin of 15 mm to the PVB group. Results: No significant differences were observed between the VAS scores of the two groups except at 48 h after surgery, with a margin noted for the PVB group. No significant differences were detected in the frequency of additional analgesics and occurrence of adverse effects. Conclusions: Our results could not clearly establish noninferiority of ICB to PVB. Improvements in ICB may be necessary for it to be used as an alternative method to PVB.

    DOI: 10.1007/s11748-018-0936-8

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  36. A resected case of secondary racemose hemangioma of the bronchial artery with a destroyed lung

    Kadomatsu Yuka, Kawasumi Yuta, Ueno Harushi, Usami Noriyasu, Uchiyama Mika, Mori Shoichi

    The Journal of the Japanese Association for Chest Surgery   Vol. 32 ( 4 ) page: 458 - 463   2018.5

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    Language:Japanese   Publisher:The Japanese Association for Chest Surgery  

    <p>A 60-year-old man was referred to his previous doctor for recurrent hemoptysis. He had a history of severe pneumonia in early childhood and was diagnosed with a poor function of the left lung. Chest computed tomography showed cystic change, volume reduction, and a dilated bronchus of the left lung. Several dilated and convoluted bronchial arteries traversing under the aortic arch and around the left hilum were identified. Left pneumonectomy was performed, as bronchial artery embolization was considered to be difficult owing to the marked dilation of the bronchial arteries. The procedure for the pulmonary artery and veins followed by en bloc resection of abnormal vessels reduced both the operative time and blood loss. The bronchial stump was covered by a latissimus dorsi muscle flap. The bleeding volume was 1,040 mL. The postoperative course was uneventful, and no hemoptysis was observed after the surgery. Surgery for racemose hemangioma of the bronchial artery is associated with difficulty in controlling bleeding owing to the fragility of abnormal vessels. In our case, left pneumonectomy was successfully performed with relatively minimal blood loss by devising a procedure for managing abnormal vessels.</p>

    DOI: 10.2995/jacsurg.32.458

    CiNii Research

  37. Reconstructive procedures and perioperative management in patients with thoracic malignancies and resection of superior vena cava and brachiocephalic veins

    Kadomatsu Yuka, Mori Shoichi, Ueno Harushi, Fukumoto Koichi, Uchiyama Mika, Shigemitsu Kikuo, Yoshioka Hiromu, Yokoi Kohei

    The Journal of the Japanese Association for Chest Surgery   Vol. 31 ( 4 ) page: 446 - 452   2017

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    Language:Japanese   Publisher:The Japanese Association for Chest Surgery  

    <p>Objective: We retrospectively analyzed reconstructive procedures, kinds of grafts used, antithrombotic therapy, and graft patency in patients with thoracic malignancies and resection of the superior vena cava (SVC) and brachiocephalic veins (BCVs).</p><p>Methods: From 2005 to 2014, 15 patients underwent resection and reconstruction of SVC and/or BCVs. We collected and reviewed their clinical data, surgical procedures, postoperative graft status, and perioperative antithrombotic therapy.</p><p>Results: The subjective tumors were thymic epithelial tumor in 11 patients, germ cell tumor in two, and lung cancer and malignant lymphoma in one each. SVC was reconstructed in 13 patients, right BCV in 12 patients, and left BCV in 14 patients. In all patients, the adopted graft diameter was ≥10 mm and antithrombotic therapy was performed. Although occlusion of the reconstructed veins was observed in six patients, the associated symptoms were rarely observed in patients whose left and right brachiocephalic pathways were maintained.</p><p>Conclusion: Procedures that require the resection of great vessels remain challenging. We did not observe perioperative deaths nor early graft occlusions in this study. In the case of graft occlusion, follow-up is possible in the absence of severe symptoms.</p>

    DOI: 10.2995/jacsurg.31.446

    CiNii Research

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Presentations 1

  1. 原発性自然気胸におけるPGAシートの断端被覆の再発予防効果 メタアナリシス

    門松由佳

    第120回 日本外科学会  2020.8.13  日本外科学会

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    Event date: 2020.8

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜  

KAKENHI (Grants-in-Aid for Scientific Research) 1

  1. 脱気変形アルゴリズムとバードビュー機能を用いた肺表面位置情報ガイドの開発への挑戦

    Grant number:21H03020  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(B)

    芳川 豊史, 中村 彰太, 中尾 恵, 北坂 孝幸, 後藤 真輝, 門松 由佳

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    Authorship:Coinvestigator(s) 

    肺は、術前CT画像は含気状態であるが、手術は脱気状態で行われるため、術前と術中の形態が大きく異なる。
    画像技術の進歩により、微小な肺結節の検出が増え、その切除には、術前マーキングが必須である。また、区域切除において、現在行われている区域間面の同定法も確実とはいえず、現在の内視鏡カメラでは視野に限界がある。
    本研究では, 侵襲的な処置をすることなく、真に低侵襲に微小肺結節を切除するために、微小結節の位置や区域間面の同定が正確に可能となるシステムを情報学的手法により構築する。また、バードビューカメラシステムを用い、肺表面の位置情報を術中にリアルタイムで、わかりやすく、正確にガイドすることを目指す。

 

Teaching Experience (On-campus) 1

  1. 4年生臨床医学総論PBLチュートリアル

    2022

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    4年生臨床医学総論PBLチュートリアル