Language：English   Publishing type：Research paper (scientific journal)   Publisher：Indian Journal of Surgical Oncology  

Purpose: This study aimed to estimate the responsiveness and minimal clinically important difference (MCID) of the 6-minute walk distance (6MWD) and isometric knee extension force (IKEF) from within 1 week before to 1 week after radical surgery in patients with gastric cancer (GC). Methods: Patients with GC (n = 29) scheduled for radical surgery were enrolled. To estimate the MCID of the 6MWD and IKEF, an anchor-based approach was applied using the EuroQol 5-Dimension 5-Level questionnaire as anchors. The effect size (ES) and standardized response mean (SRM) of the 6MWD and IKEF were calculated to evaluate responsiveness, and the receiver operating characteristic (ROC) curve was used to estimate the MCID of the 6MWD and IKEF. Results: Of the 29 patients, 22 were included in the analysis. The absolute value of ES and SRM values for the 6MWD were 0.83 and 1.35, and for the IKEF, 0.27 and 0.71, respectively. The ROC curve indicated that the optimal cut-off value for estimating the MCID of the 6MWD was -170 m (area under the curve [AUC] = 0.938 [95% confidence interval {CI}: 0.837−1.000]), and for estimating the IKEF, -6.7 kgf (AUC = 0.812 [95% CI: 0.592−1.000]). Conclusion: During the perioperative period from within 1 week before to 1 week after surgery, the responsiveness of the 6MWD was favorable, but that of the IKEF was comparatively weaker. The estimated MCIDs were -170 m for the 6MWD and -6.7 kgf for the IKEF in patients with GC.

DOI： 10.1007/s13193-026-02573-z

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BMJ Supportive and Palliative Care  

Objective This study aimed to investigate the factors for increasing sedentary time during neoadjuvant chemotherapy (NAC) in older patients with locally advanced oesophageal cancer (LAEC) and to elucidate potential clinical mechanisms. Methods We conducted a single-centre exploratory prospective cohort study. Between October 2021 and December 2023, consecutive 80 patients with LAEC aged ≥65 years were scheduled for curative oesophagectomy after NAC. The change in sedentary time (Δ=afterNAC-before NAC; expressed in min/week) was calculated from sedentary time measured by the Global Physical Activity Questionnaire. Factors associated with the change in sedentary time were investigated using a multivariate regression model. Two-tailed statistical significance was accepted at p<0.05. Results A total of 69 patients were included in the analysis. The mean age was 72.9 years, and docetaxel+cisplatin + fluorouracil, cisplatin+fluorouracil and oxaliplatin+leucovorin + fluorouracil regimens were administered to 46 (67%), 4 (6%) and 19 (27%) patients, respectively. The mean sedentary times before and after chemotherapy were 3235±1477min/week and 3557±1598min/week, and the mean change in sedentary time during chemotherapy was 322±736min/week. Worsening fatigue was a significant factor influencing increased sedentary time during chemotherapy (vs non-worsening fatigue, adjusted coefficient 531.111, 95% CI 104.960 to 957.261, p=0.015). Conclusions The clinical mechanism of increasing sedentary time during chemotherapy may be associated with worsening fatigue. In older adults with LAEC, a physical activity intervention during NAC may improve clinical outcomes.

DOI： 10.1136/spcare-2025-005940

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Discover Oncology  

Purpose: This systematic review and meta-analysis aimed to determine whether home-based preoperative physical activity (PA) influenced the incidence of postoperative complications (PCs) in patients who underwent oncologic surgery. Methods: A comprehensive literature search was conducted using five electronic databases. Full articles with observational designs that compared by preoperative PA or PCs were included. The primary outcome was some type of PC, and a meta-analysis was performed to determine the impact of preoperative low PA on the incidence of PCs. Sub-analysis was performed to identify subgroups based on the severity of the PCs and the cancer site. Results: Eight studies were included in the analysis. Low preoperative PA was associated with all PCs (odds ratio [OR] = 2.42, 95% confidence interval [CI] = 1.44 to 4.07) but not with severe PCs (OR = 1.93, 95% CI = 0.51 to 7.37). In a subgroup of patients with gastrointestinal cancers, low preoperative PA was associated with all PCs (OR = 3.44, 95% CI = 1.63 to 7.26) and severe PCs (OR = 2.93, 95% CI = 1.30 to 6.58). Conclusions: This systematic review and meta-analysis revealed that patients with low preoperative PA undergoing oncologic surgery, particularly those with gastrointestinal cancers, are more likely to develop PCs. A definitive conclusion could not be reached, however, due to the limited number of studies exclusively examining this relationship in cancer patients.

DOI： 10.1007/s12672-025-03430-1

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Surgical Oncology  

Backgrounds: Currently, there is a lack of evidence of prehabilitation during neoadjuvant chemotherapy (NAC) to prevent pneumonia of older patients. This study aimed to investigate the association of preoperative physical fitness after NAC with post-esophagectomy pneumonia in older patients with locally advanced esophageal cancer (LAEC). Methods: This single-center exploratory prospective cohort study included 80 patients aged ≥ 65 years with LAEC scheduled for curative esophagectomy after NAC between 2021 and 2023. The post-NAC short incremental shuttle walk test (ISWT) by sex was established using the Youden index. The association of the post-NAC short ISWT with postoperative pneumonia was investigated via Firth's penalized logistic regression model with statistical significance set as two-tailed p < 0.05. Results: A total of 69 patients were analyzed. The mean post-NAC ISWT values were 353.5 m. Short ISWT distance was defined as ≤ 395 and ≤ 195 m for men and women, respectively. Postoperative pneumonia developed in 17 (25%) patients. Short post-NAC ISWT distance was significantly associated with postoperative pneumonia (adjusted odds ratio: 1.840, 95%CI: 1.760–28.440, p = 0.004). Conclusions: Decline in physical fitness was associated with post-esophagectomy pneumonia, which may be a key targeted factor of prehabilitation during NAC for older patients with LAEC.

DOI： 10.1002/jso.28068

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Cachexia Sarcopenia and Muscle  

Background: In our previous study (NEXTAC-ONE), the Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) program (including home-based exercise and branched-chain amino acid-containing supplements combined with nutritional counselling) was shown to potentially prevent low muscle mass-related disability in elderly cancer patients. This randomized controlled trial (NEXTAC-TWO) was conducted to elucidate whether the NEXTAC program prolongs disability-free survival in elderly patients with advanced pancreatic or non-small cell lung cancer. Methods: This open-label, multicentre, randomized phase II study was conducted at 15 Japanese hospitals. Patients aged ≥ 70 years, with pathologically proven advanced pancreatic or non-small cell lung cancer, who were scheduled to undergo systemic chemotherapy for treatment-naïve tumours were randomly assigned (1:1) to undergo observation or receive the NEXTAC program for 12 weeks. Randomization was performed by the minimization method, using performance status and types with cancer diagnosis and anticancer treatment as adjustment factors. The primary endpoint was disability-free survival (period from randomization to the date patients were evaluated as needing care or death due to any cause). Key secondary endpoints were change in weight, muscle mass, physical activity, nutritional assessment, safety and survival. This trial was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN000028801). Results: From 2017 to 2019, 131 patients were enrolled and randomly assigned to NEXTAC (n = 66) or control arms (n = 65, median age 76.0 years). After randomization, two patients in the NEXTAC arm declined further participation. As a result, 64 patients (median age 75.5 years) received at least one session of the NEXTAC program. The completion rate of the planned exercise and nutrition consultation sessions was 98.4% in the NEXTAC arm. Of the 129 patients, 91 (71%) had a disability (44 in the NEXTAC arm; 47 in the control arm). In the primary analysis, median disability-free survival periods were 478 days (95% confidence interval [CI], 358–576) in the NEXTAC arm and 499 days in the control arm (95% CI, 363–604), with no significant differences between them (p = 0.884). The hazard ratio for disability-free survival in the NEXTAC arm compared with the control arm was 0.970 (95% CI 0.642–1.465). There were no differences in the secondary endpoints between the two arms. Conclusions: The patients had good compliance with the 12-week NEXTAC program but failed to show significant improvements in disability-free survival as compared to observation alone. Further study on the progression of low muscle mass in the NEXTAC arm is needed.

DOI： 10.1002/jcsm.13871

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Supportive Care in Cancer  

Purpose: The decline in physical fitness during neoadjuvant chemotherapy (NAC) impacts postoperative pneumonia and survival in older patients with locally advanced esophageal cancer (LAEC). However, information is lacking on the clinical mechanisms underlying the decline in physical fitness during NAC in older patients. This study investigated the factors responsible for the decline in physical fitness during NAC in older patients with LAEC. Methods: This was a single-center exploratory prospective cohort study. A total of 80 patients with LAEC aged ≥ 65 years who were scheduled for curative esophagectomy after NAC were consecutively enrolled between October 2021 and December 2023. The decline in the incremental shuttle walking test (ΔISWT; ΔISWT = pre-NAC (m) − post-NAC (m)) was calculated to assess physical fitness. Significant factors responsible for ΔISWT were detected using a multivariate regression model. Statistical significance was two-tailed at p < 0.05. Results: A total of 69 patients (mean age, 72.9 years) were analyzed. The mean ISWT distances before and after NAC were 418.7 m and 353.5 m, respectively; the mean ΔISWT was 65.2 m. Significant responding factors for the decline in physical fitness during NAC were changes in skeletal muscle mass index (SMI; adjusted coefficient − 14.239 cm²/m², 95% confidence interval − 19.690 to − 8.788, p < 0.001) and decreased hemoglobin (Hb; vs. non-decreased Hb, adjusted coefficient 33.907, 95% confidence interval 9.913 to 64.288, p = 0.008) during NAC. Conclusion: This prospective cohort study found that the significant factors for the decline in physical fitness during NAC were loss of skeletal muscle mass and decreased Hb during NAC in older patients with LAEC.

DOI： 10.1007/s00520-025-09495-6

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Japanese Journal of Clinical Oncology  

Objective: This research aimed to establish the inaugural evidence-based cancer survivorship guidelines for Japan, with a particular focus on exercise and physical activity, in order to enhance health outcomes for cancer survivors. Methods: A panel of experts, including oncologists, physicians, exercise scientists, epidemiologists and patient advocates, utilized a modified Delphi process and systematic reviews to establish consensus on exercise recommendations for cancer survivors. The panel focused on setting the objectives of the Clinical Practice Guidelines and addressing crucial clinical issues in Japan. Recommendations were formulated based on the strength and certainty of evidence, the benefit-harm balance and patient values and preferences. Results: The panel formulated exercise recommendations for cancer survivors of two age groups: 18-64 years and ≥65 years. The recommendations for both age groups are consistent, emphasizing the importance of regular exercise and physical activity tailored to individual capabilities and health conditions. The guidelines underline the benefits of exercise in improving the overall health and quality of life of cancer survivors. This consensus on exercise recommendations marks a significant step in the development of comprehensive cancer survivorship guidelines in Japan, with potential implications for improving clinical outcomes and advancing research in cancer survivorship. Conclusions: These guidelines will serve as a critical resource for cancer survivors, highlighting exercise as a key component of survivorship care, and for clinicians, in recommending appropriate physical activities to improve survivor health and well-being.

DOI： 10.1093/jjco/hyae126

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Diseases of the Esophagus  

In older patients with locally advanced esophageal cancer (LAEC), loss of skeletal muscle mass during neoadjuvant chemotherapy (NAC) is associated with poor clinical outcomes. This study aimed to investigate factors associated with loss of skeletal muscle mass during NAC in older patients with LAEC. This was a single-center exploratory prospective cohort study. Consecutive patients aged ≥65 years with LAEC scheduled for curative esophagectomy after NAC were enrolled between October 2021 and December 2023. As a primary endpoint, loss of skeletal muscle mass index (∆SMI: pre-NAC minus post-NAC value) was calculated from computed tomography images before and after NAC. Significant pre-NAC and during-NAC factors with ∆SMI were detected with a multivariate regression model. Statistical significance was considered as two-tailed P <0.05. A total of 69 patients were analyzed. The mean age was 72.9 years, and 53 (77%) were male. Mean SMI before and after NAC was 43.1 and 40.9 cm²/m², and mean ∆SMI was 2.2 cm²/m². In multivariate analysis, ∆SMI was associated with increased sitting time during NAC (per 1 min/day, adjusted coefficient 0.007, 95% confidence interval [CI] 0.001 to 0.013, P = 0.016), decreased Geriatric Nutritional Risk Index during NAC (per 1 score, adjusted coefficient −0.146, 95% CI −0.213 to −0.013, P = 0.002), and worsening decreased appetite during NAC (vs. no worsening, adjusted coefficient 1.571, 95% CI 0.279 to 2.862, P = 0.018). It was hypothesized that the inactivity-related mechanism and malnutrition-related mechanism are important for skeletal muscle mass loss during NAC in older patients with LAEC.

DOI： 10.1093/dote/doae096

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BMJ Supportive and Palliative Care  

Objective Physical functioning (PF), emotional functioning (EF), overall quality of life (QOL) and activities of daily living (ADL) such as walking and toilet transfer are the primary outcomes of dignity in patients with terminal cancer. However, few studies have investigated the association of PF, EF and overall QOL with ADL based on end-of-life stages in patients with cancer who are receiving at-home palliative care. Methods This prospective cohort study included 88 patients with terminal cancer receiving home-based rehabilitation as part of their home-based palliative care at the Mariana Home Nursing Station (Nagoya-city, Aichi, Japan). The variables were measured at 4 and 2weeks before death of patients. PF, EF and overall QOL scores were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 Palliative Care and ADL were assessed using the Functional Independence Measure-motor items. Multiple regression analysis was used to examine the association, considering the effect of physical symptoms. Results PF and overall QOL scores at 4 and 2weeks before death were significantly associated with toilet transfer and walking scores, even after considering the influence of physical symptoms. EF scores were significantly associated with toilet transfer and walking scores 4weeks before death, but not 2weeks before death. Conclusions In addition to managing physical symptoms, supporting ADL such as walking and toilet transfer is necessary to maintain PF, EF and overall QOL in patients with terminal cancer receiving home-based palliative care. This may help preserve their dignity, even in deteriorating general condition.

DOI： 10.1136/spcare-2024-005032

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：一般社団法人 日本サルコペニア・フレイル学会  

<p> <b>［目　的］</b> </p><p>地域在住高齢者における基本チェックリストで判定したプレフレイルに関連する身体機能およびカットオフ値を検討すること。</p><p> <b>［方　法］</b> </p><p>A 町の健診事業に参加した65歳以上の高齢者198名を解析対象とした。基本チェックリストを利用し，ロバスト群，プレフレイル群の2群に分類し，2群間で身体機能評価との関連性を分析した。その後，プレフレイルを目的変数とした，単変量及び多変量解析を行った。</p><p> <b>［結　果］</b> </p><p>多重ロジスティック回帰分析の結果，プレフレイル群はロバスト群よりも最大歩行速度が有意に低下していた（p＜0.001）。また，プレフレイルに対する最大歩行速度のカットオフ値は1.61m/sであった（感度51.7％，特異度87.0％）。</p><p> <b>［結　論］</b> </p><p>プレフレイルと関連する身体機能評価は最大歩行速度であり，客観的指標として最大歩行速度1.61m/sより速い場合は，ロバストである可能性が高いことが示唆された。</p>

DOI： 10.69303/jjasf.8.1_98

CiNii Research

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Supportive Care in Cancer  

Purpose: This study aimed to clarify the responsiveness and minimal clinically important difference (MCID) of the 6-minute walk distance (6MWD) from before and 1 week after surgery in patients with colorectal cancer (CRC). Methods: This retrospective cohort study enrolled 97 patients with primary CRC scheduled for surgery. An anchor-based approach estimated the MCID of the 6MWD, with postoperative physical recovery and EuroQol 5-dimension 5L questionnaire assessments serving as anchors. Effect size (ES) and standardized response mean (SRM) of the 6MWD were calculated to evaluate responsiveness, and the receiver operating characteristic (ROC) curve was used to estimate the MCID of the 6MWD. Results: Of the 97 patients, 72 were included in the analysis. The absolute value of ES and SRM of the 6MWD were 0.69 and 0.91, respectively. The ROC curve indicated that the optimal cut-off values for estimating the MCID of the 6MWD were -60 m (area under the curve [AUC] = 0.753 [95% CI: 0.640−0.866]) and -75 m (AUC = 0.870 [95% CI: 0.779−0.961]) at each anchor. Conclusion: From before to 1 week after surgery, the responsiveness of the 6MWD was favorable, and the MCID of the 6MWD was -75 to -60 m in patients with CRC.

DOI： 10.1007/s00520-024-08596-y

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Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Society of Physical Therapy Science  

<p> [Purpose] To clarify the association between preoperative physical activity and postoperative ambulation based on physical activity intensity, and independent of functional capacity and depression, in patients with gastrointestinal cancer. [Participants and Methods] Seventy patients who underwent surgery for primary colorectal or gastric cancer were enrolled. Preoperative moderate-to-vigorous-intensity physical activity, light-intensity physical activity, and sedentary behavior were assessed using an accelerometer. The primary outcome was the days to postoperative first ambulation (capable of independently and continuously walking 150 m). Functional capacity and depression, as confounders, were evaluated by measuring the 6-minute walk distance and using the Hospital Anxiety and Depression Scale. [Results] Of the 70 patients, 28 had insufficient accelerometer data, and 42 were included in the analysis. Preoperative light-intensity physical activity, but not moderate-to-vigorous-intensity physical activity and sedentary behavior, was negatively associated with the days to postoperative first ambulation, after adjusting for age, preoperative functional capacity, and preoperative depression. [Conclusion] Preoperative light-intensity physical activity was associated with the days to postoperative ambulation independently of age, functional capacity, and depression. Hence, predicting delayed ambulation by preoperative light-intensity physical activity in patients with gastrointestinal cancer may be useful.</p>

DOI： 10.1589/jpts.36.1

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1177/11795565241281334

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：European Journal of Cancer Care  

Purpose. Skeletal muscle mass (SMM) is an important biomarker for health in older cancer patients. However, there is limited information on the recovery course of SMM after esophagectomy in older patients. This study aimed to investigate the recovery course of SMM after esophagectomy and the predictors in older cancer patients. Methods. We conducted a single-center, retrospective cohort study. Esophageal cancer patients who underwent esophagectomy were included. The skeletal muscle mass index (SMI) was calculated using computed tomography images. The loss of SMI at 4 and 12 months after surgery was calculated as [(preoperative − postoperative SMI) ÷ preoperative SMI] × 100%. Nonrecovery was defined as an SMI loss of ≥2% at 12 months after surgery, considering physiological loss with aging. One-way analysis of variance and multivariate logistic regression analysis was used for statistical analysis. Results. A total of 105 older (≥70 years) and 156 nonolder (<70 years) patients were analyzed. Older patients had a significantly larger loss of SMI 4 months (mean: 5.7% vs. 3.1%; p = 0.021) and 12 months (mean: 1.0% vs. −1.4%; p = 0.040) after surgery than nonolder patients. In older patients, the number of patients with nonrecovery of SMI at 12 months after surgery was 55 (52%). In older patients, significant predictors for the nonrecovery of SMI were preoperative sarcopenia (adjusted OR: 0.297; p = 0.012), neoadjuvant chemotherapy (adjusted OR: 0.248; p = 0.015), and loss of SMI 4 months after surgery (per 1%; adjusted OR: 1.076; p = 0.018). Conclusions. It is suggested that older esophageal cancer patients have a larger unmet need for long-term postoperative loss of SMM than nonolder patients. Continuous outpatient rehabilitation, including exercise and nutritional therapy after discharge, which targets improvement in SMM at 4 months, may improve SMI at 12 months after surgery in older esophageal cancer patients.

DOI： 10.1155/2023/6655999

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：European Geriatric Medicine  

Background: Loss of skeletal muscle mass, measured by the skeletal muscle mass index (SMI), after esophagectomy negatively impacts prognosis. However, the information to develop novel supportive care options for preventing loss of skeletal muscle mass is limited. The purpose of this retrospective cohort study was to investigate the impact of early postoperative factors on change in SMI 4 months after curative esophagectomy in older patients with esophageal cancer. Methods: This study included 113 subjects who underwent esophagectomy between 2015 and 2020. Preoperative and postoperative SMI (cm2/m2) were calculated from computed tomography images. The percentage change in SMI 4 months after surgery (SMI%) was calculated as follows: ([postoperative SMI – preoperative SMI] ÷ preoperative SMI) × 100. Potential factors affecting percentage change of SMI after surgery were analyzed by multiple regression. Results: The mean SMI% was – 5.6%. The percentage change (per 1%) in quadriceps muscle strength in the first month after surgery (standardized β = 0.190, p = 0.048) impacted the SMI%, which was independent of age, sex, preoperative SMI, comorbidity, pathological stage, and neoadjuvant chemotherapy. Conclusion: Quadriceps muscle weakness in the first month after esophagectomy impacted the SMI% in a dose-dependent relationship.

DOI： 10.1007/s41999-022-00735-0

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Cancer Rehabilitation  

Background A preoperative intervention called “prehabilitation” has become increasingly important to prevent postoperative complications. Prescribing tailor-made programs according to patient characteristics is essential to enhance the benefits of this intervention. However, data on the physical characteristics of preoperative gastrointestinal cancer patients with myopenia or myosteatosis are lacking, especially for Asian individuals. This study aimed to determine the characteristics of physical function in preoperative gastrointestinal cancer patients with skeletal muscle abnormalities.Materials and Methods This single-center cross-sectional study included patients who underwent open or laparoscopic surgery for primary colorectal or gastric cancer between October 2016 and August 2020. Skeletal muscle mass and density were measured using preoperative computed tomography images at the level of the third lumbar vertebra. Skeletal muscle abnormalities (myopenia / myosteatosis) were defined using sex-and age-specific thresholds based on previous studies. The assessment of preoperative physical function included handgrip strength, isometric knee-extensor muscle force, and 6-minute walking distance. Patients were divided into the following four groups; 1) normal group; 2) myopenia / non-myosteatosis group; 3) non-myopenia / myosteatosis group; 4) myopenia / myosteatosis group. Preoperative physical functions were compared between the normal and other groups.Results Overall, 126 patients with a median age of 69 years were included in the analysis. The prevalence of myopenia and myosteatosis in the patients was 63% and 52%, respectively. Patients with both skeletal muscle abnormalities (myopenia and myosteatosis) had poorer physical function than normal patients.Conclusions More than half of the Japanese preoperative patients with gastrointestinal cancer had either myopenia or myosteatosis, and the patients with both myopenia and myosteatosis were considered as a “high risk for severe sarcopenia” population. This information can be used to prescribe an optimal, customized treatment to preoperative patients with gastrointestinal cancer.

DOI： 10.48252/JCR85

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Annals of Surgical Oncology  

Background: The number of patients with esophageal cancer aged ≥ 70 years with a poor prognosis is increasing. In general patients with esophageal cancer, postoperative loss of skeletal muscle mass (SMM) is a prognostic factor. This study was designed to investigate the prognostic impact of postoperative loss of SMM in patients aged ≥ 70 years with esophageal cancer. Methods: This study was a single-center, retrospective cohort study. Patients with esophageal cancer who underwent R0 esophagectomy between 2016 and 2020 were included. The percentage postoperative loss of skeletal muscle mass index (SMI%) was calculated using computed tomography images before and at 4 ± 2 months after surgery. Results: The number of subjects in the ≥ 70-year and < 70-year age groups was 166 and 218, respectively. The median SMI% was 5% in all patients; thus, 5% was defined as the cutoff point to define major loss of SMI. Major loss of SMI impacted 3-year overall survival (OS) in the ≥ 70-year age group, independent of age, sex, clinical stage, pathological T and N factors, Charlson comorbidity index, and length of hospital stay (adjusted hazard ratio [HR]: 4.400; 95% confidence interval: 1.202–16.105; P = 0.025). The adjusted HR of major loss of SMI in the ≥ 70-year age group was higher than in the < 70-year age group (adjusted HR: 4.400 vs. 2.388, respectively). Conclusions: Postoperative loss of SMI in patients with esophageal cancer aged ≥ 70 years more strongly impacted 3-year OS than in patients aged < 70 years.

DOI： 10.1245/s10434-022-11801-z

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society of Physical Therapy  

<p><b>Objective</b>: This study aimed to investigate the characteristics of physical performance measures for people aged over 65 years who are at risk for locomotive syndrome stage 1, and to examine the cut-off value of the physical performance measures for locomotive syndrome stage 1.</p><p><b>Methods</b>: This study population consisted of 182 people aged 65 and above who participated in a medical examination project in a municipality near Nagoya University. Using the locomotive syndrome risk test, the participants were divided into groups with and without locomotive syndrome stage 1. The relationship of locomotive syndrome stage 1 with the physical performance measures was analyzed between the two groups. The cut-off values were examined for the factors that were significantly associated with locomotive syndrome stage 1.</p><p><b>Results</b>: As determined by logistic regression analysis, one-leg standing time with eyes open showed a significant association with locomotive syndrome stage 1 (p<0.01). In addition, one-leg standing time with eyes open for 17.0 s was found to be the cut-off value for locomotive syndrome stage 1 (AUC=0.66, sensitivity: 42%, specificity: 88%).</p><p><b>Conclusions</b>: It was observed that the most relevant physical performance measure for locomotive syndrome stage 1 was one-leg standing time with eyes open. It was observed that 17.0 s was the cut-off value for one-leg standing time with eyes open for locomotive syndrome stage 1.</p>

DOI： 10.15063/rigaku.12154

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CiNii Research

Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Asian Pacific Journal of Cancer Prevention  

Background: Postoperative delirium (POD) is one of the most common postoperative complications in gastrointestinal surgery patients. POD has been reported to affect long-term activities of daily living, cognitive function decline, and mortality. Previous studies have indicated that preoperative physical activity (PA) predicted POD in patients with other diseases, but we have not found any reports in patients with gastrointestinal cancer. In this retrospective study, we investigated the relationship between preoperative PA and POD in gastrointestinal cancer patients. Methods: POD was diagnosed based on the short confusion assessment method. We divided patients into active and inactive groups based on their preoperative PA assessed by the International Physical Activity Questionnaire (Japanese version). Multivariate logistic analysis was conducted to investigate the association between preoperative PA and POD. Results: POD occurred in 25 of the 151 patients (16.6%). Preoperative low PA was associated with POD after adjusting for confounders, namely, diabetes mellitus, sedentary time, and usual gait speed (odds ratio, 2.83; 95% confidence interval: 1.06-7.58; p=0.03). Conclusion: Preoperative low PA was a predictor of POD independent of the confounding factors in patients with gastrointestinal cancer.

DOI： 10.31557/APJCP.2022.23.5.1753

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Supportive Care in Cancer  

Purpose: A known barrier to getting breast cancer survivors (BCSs) to engage in habitual exercise is a lack of information on recommended physical activity levels provided to them by oncology care providers (OCPs). However, the actual situation in Japan remains unclear. This study sought to clarify OCPs’ awareness and practice related to Japan’s physical activity recommendation for BCSs and to ascertain barriers to routine information provision. Methods: We conducted a web-based survey involving members of the Japanese Breast Cancer Society (JBCS) and the Japanese Association of Cancer Rehabilitation between Dec. 2018 and Feb. 2019. Results: Of 10,830 members, 1,029 (9.5%) responded. Only 19.1% were aware of the details of the JBCS physical activity recommendation, and only 21.2% routinely provided physical activity information to BCSs. Factors related to being aware of the recommendation details were 1) availability of the guidelines, 2) experience reading relevant parts of the guidelines, and 3) involvement in multidisciplinary team case meetings. Barriers to routine information provision were 1) absence of perceived work responsibility, 2) underestimation of survivors’ needs, 3) lack of resources, 4) lack of self-efficacy about the recommendation, and 5) poor knowledge of the recommendation. Conclusions: Only one fifth of the OCPs routinely provided physical activity information. Barriers to provision were poor awareness, self-efficacy, and attitudes and unavailable resources. The physical activity recommendation needs to be disseminated to all OCPs and an information delivery system needs to be established for BCSs to receive appropriate information and support to promote their engagement in habitual physical activity.

DOI： 10.1007/s00520-021-06706-8

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Japanese Society for Palliative Medicine  

<p>​Objective: The purpose of this study was to clarify the characteristics of physical quality of life (QOL) and activities of daily living (ADL) in patients with advanced cancer undergoing home-visit rehabilitation. Method: In this prospective study, we included 35 patients with advanced cancer undergoing home-visit rehabilitation. Physical QOL was assessed using the Physical Functioning (PF) score on the QLQ-C15, and ADL was assessed using the Barthel Index (BI) and Functional Independence Measure (Motor FIM) scores. Changes in physical QOL and each ADL scores from the start of rehabilitation to 4 weeks later were investigated. Also, patients were divided into two groups according to the PF score and characteristics of physical QOL and ADL between the two groups were explored. Result: PF score was significantly improved after 4 weeks compared to baseline. In the PF score maintenance/improvement group, motor FIM score was significantly improved after 4 weeks compared to baseline. Conclusion: The physical QOL of patients with advanced cancer undergoing home-visit rehabilitation was maintained and improved 4 weeks after the start of rehabilitation. It was suggested that maintaining ADL may lead to maintenance and improvement of physical QOL.</p>

DOI： 10.2512/jspm.16.271

CiNii Research

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Cancer Rehabilitation  

The longitudinal relationship between cancer-related fatigue (CRF) and physical function remains unclear. This study evaluated the association between pre-treatment physical functions and CRF exacerbation following concurrent chemoradiotherapy (CCRT). Methods The study included 42 cancer patients undergoing CCRT. Poor physical function was defined as the presence of either or both low grip strength (<26 kg, <18 kg) and slow walking speed (<1.0 m/s) at the start of CCRT. CRF was assessed using the Japanese version of the Functional Assessment of Chronic Illness Therapy-Fatigue Scale at the start of CCRT and 6 weeks later. Patients were categorized into the CRF exacerbation group if their scores decreased by >3 points. A multivariate logistic regression analysis was performed to identify the association between poor physical function and exacerbation of CRF. Results Seventeen (40.5%) patients developed CRF exacerbation following CCRT. More patients had poor physical function in the CRF exacerbation group (58.8% vs. 20.0%; p=0.02). Poor physical function was an independent risk factor for exacerbation of CRF following CCRT after adjusting for confounders. Conclusions Poor physical function was a risk factor for exacerbation of CRF following CCRT. Assessing physical function may be useful in determining patients at high risk for CRF exacerbation following CCRT.

DOI： 10.48252/JCR34

Scopus

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.31557/APJCP.2020.21.11.3405

Scopus

PubMed

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1001/jamasurg.2020.1804

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s11764-019-00840-3

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1161/STROKEAHA.119.026683

PubMed

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1186/s12885-019-5762-6

Open Access

PubMed

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/jcsm.12351

Open Access

PubMed

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.4103/apjon.apjon_21_18

Open Access

PubMed

Authorship：Lead author   Language：Japanese   Publishing type：Research paper (scientific journal)  

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.gaitpost.2014.07.012

PubMed

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.clinbiomech.2013.08.005

PubMed

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1097/COC.0b013e3182354bf4

PubMed

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.7314/apjcp.2013.14.1.47

Open Access

PubMed

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1007/s00520-010-0874-1

PubMed

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.gerinurse.2011.02.002

PubMed

Event date： 2024.7

Language：Japanese   Presentation type：Oral presentation (general)  

Event date： 2024.7

Language：Japanese   Presentation type：Oral presentation (general)  

Event date： 2024.6

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Event date： 2024.2

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Event date： 2023.10

Language：Japanese   Presentation type：Oral presentation (general)  

Event date： 2023.10

Language：Japanese   Presentation type：Oral presentation (general)  

Event date： 2023.9

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Event date： 2023.6 - 2023.7

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Event date： 2023.6

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Event date： 2022.10

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Event date： 2022.10

Language：Japanese   Presentation type：Oral presentation (general)  

Event date： 2022.10

Language：Japanese   Presentation type：Oral presentation (general)  

Event date： 2022.9

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Event date： 2022.7

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Event date： 2022.6

Language：Japanese   Presentation type：Oral presentation (general)  

Event date： 2021.2

Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2021.2

Language：English   Presentation type：Symposium, workshop panel (nominated)  

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Event date： 2021.1

Language：English   Presentation type：Oral presentation (general)  

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Event date： 2020.12

Language：English   Presentation type：Poster presentation  

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Event date： 2020.8

Language：English   Presentation type：Symposium, workshop panel (nominated)  

researchmap

Language：Japanese   Presentation type：Poster presentation  

DOI： 10.60366/jjptol.jjptol-r7-p4-6

CiNii Research

Language：Japanese   Presentation type：Oral presentation (general)  

DOI： 10.60366/jjptol.jjptol-r7-p10-6

CiNii Research

Language：Japanese   Presentation type：Oral presentation (general)  

DOI： 10.60366/jjptol.jjptol-r7-o-3

CiNii Research

Language：Japanese   Presentation type：Oral presentation (general)  

DOI： 10.60366/jjptol.jjptol-r6-o7-1

CiNii Research