Updated on 2021/10/20

写真a

 
MATSUSHIMA Shigeru
 
Organization
Graduate School of Medicine Associate professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Associate professor
Contact information
メールアドレス

Degree 1

  1. 博士(工学) ( 2002.3   名古屋工業大学 ) 

Research Interests 7

  1. Oncology Imaging

  2. 分子イメージング

  3. MRI

  4. 磁化移動効果

  5. 分子イメージング

  6. がん

  7. MRI

Research Areas 1

  1. Life Science / Radiological sciences

Current Research Project and SDGs 2

  1. MRIによる臨床腫瘍イメージングの開発

  2. MRIによる臨床分子イメージングの開発

Education 1

  1. Nagoya Institute of Technology   Graduate School, Division of Engineering

    1999.4 - 2002.3

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    Country: Japan

Professional Memberships 3

  1. 日本放射線医学会

  2. 日本磁気共鳴医学会

  3. 日本分子イメージング学会

Awards 1

  1. 第66回日本医学放射線学会Gold Medal賞

    2007.4   日本医学放射線学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 31

  1. Comparison of radiopaque dye materials for localization of pulmonary nodules before video-assisted thoracic surgery. Reviewed

    Hasegawa T, Kuroda H, Chatani S, Furuya Y, Sato Y, Iwamasa H, Asai T, Yashiro H, Matsushima S, Inaba Y

      Vol. 12 ( 5 ) page: 2070 - 2076   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21037/jtd-19-4057

    PubMed

  2. Development of twist-correction system for radiotherapy of head and neck cancer patients Reviewed

    Hidetoshi Shimizu, Koji Sasaki, Takahiro Aoyama, Shigeru Matsushima, Taiki Isomura, Hiroshi Fukuma, Hiroyuki Tachibana, Takeshi Kodaira

    JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS   Vol. 20 ( 7 ) page: 128 - 134   2019.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    To propose a concept for correcting the twist between the head and neck and the body frequently occurring in radiotherapy patients and to develop a prototype device for achieving this. Furthermore, the operational accuracy of this device under no load was evaluated. We devised a concept for correcting the twist of patients by adjustment of the three rotation (pitch, roll, and yaw) angles in two independent plates connected by a joint (fulcrum). The two plates (head and neck plate and body plate) rotate around the fulcrum by adjusting screws under each of them. A prototype device was created to materialize this concept. First, after all adjusting screws were set to the zero position, the rotation angle of each plate was measured by a digital goniometer. Repeatability was evaluated by performing 20 repeated measurements. Next, to confirm the rotational accuracy of each plate of the prototype device, the calculated rotation angles for 20 combinations of patterns of traveled distances of the adjusting screws were compared with those measured by the digital goniometer and cone-beam computed tomography (CT). The repeatability (standard deviation: SD) of the pitch, roll, and yaw angles of the head and neck plate was 0.04 degrees, 0.05 degrees, and 0.03 degrees, and the repeatability (SD) of the body plate was 0.05 degrees, 0.04 degrees, and 0.04 degrees, respectively. The mean differences +/- SD between the calculated and measured pitch, roll, and yaw angles for the head and neck plate with the digital goniometer were 0.00 +/- 0.06 degrees, -0.01 +/- 0.06 degrees, and -0.04 +/- 0.04 degrees, respectively. The differences for the body plate were -0.03 +/- 0.04 degrees, 0.03 +/- 0.05 degrees, and 0.02 +/- 0.05 degrees, respectively. Results of the cone-beam CT were similar to those of the digital goniometer. The prototype device exhibited good performance regarding the rotational accuracy and repeatability under no load. The clinical implementation of this concept is expected to reduce the residual error of the patient position due to the twist.

    DOI: 10.1002/acm2.12667

    Web of Science

    Scopus

    PubMed

  3. Predicting chemotherapeutic response for colorectal liver metastases using relative tumor enhancement of gadoxetic acid disodium-enhanced magnetic resonance imaging Reviewed

    Murata S, Matsushima S, Sato Y, Yamaura H, Hasegawa T, Muro K, Inaba Y.

    Abdom Radiol (NY)   Vol. 43 ( 12 ) page: 3301-3306   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  4. Predicting chemotherapeutic response for colorectal liver metastases using relative tumor enhancement of gadoxetic acid disodium-enhanced magnetic resonance imaging Reviewed

    Shinichi Murata, Shigeru Matsushima, Yozo Sato, Hidekazu Yamaura, Mina Kato, Takaaki Hasegawa, Kei Muro, Yoshitaka Inaba

    Abdominal Radiology   Vol. 43 ( 12 ) page: 3301 - 3306   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer New York LLC  

    Purpose: This study aimed to predict the treatment response for colorectal liver metastases (CLM) using relative tumor enhancement (RTE) of the hepatobiliary phase (HBP) for patients with no history of chemotherapy. Materials and methods: In this retrospective study, we enrolled 26 patients [14 males, 12 females
    median age: 58 years (range 37–82 years)] with CLM and no history of chemotherapy between December 2011 and May 2017. Gadoxetic acid-enhanced magnetic resonance imaging was performed before starting chemotherapy and RTE of HBP. The response was evaluated using RECIST ver.1.1, and progression-free survival (PFS) was estimated. Results: Based on the RECIST ver.1.1, there were 15 responders and 11 non-responders. In the tumor, the mean pretreatment RTE values were significantly higher in the responders group than in the non-responders group (37.2% ± 10.9% vs. 17.9% ± 10.5%, respectively
    P = 0.0006). When the threshold values of parameters for detecting responders comprised the RTE value of 24.2% (area under the curve value, 0.90), the sensitivity and specificity were 93.3% and 72.7%, respectively. The median follow-up period for 26 patients was 602 days (range 160–1971 days). Although no significant differences were observed in PFS between the groups, the high RTE group tended to take longer to progress than the low RTE group (PFS of the high RTE group did not reach the median). Conclusion: This study suggests that the RTE value of CLM could be a potential biomarker to predict early treatment response.

    DOI: 10.1007/s00261-018-1615-z

    Scopus

    PubMed

  5. Intraarterial Therapy Using Micellar Nanoparticles Incorporating SN-38 in a Rabbit Liver Tumor Model Reviewed

    Hideyuki Nishiofuku, Toshihiro Tanaka, Yasushi Fukuoka, Takeshi Sato, Tetsuya Masada, Shota Tatsumoto, Masayuki Sho, Ichiro Yamato, Satoshi Yasuda, Shigeru Matsushima, Masato Takano, Chiho Ohbayashi, Kimihiko Kichikawa

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY   Vol. 28 ( 3 ) page: 457 - 464   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Purpose: To evaluate the pharmacokinetics of intraarterial (IA) administration of micellar nanoparticles incorporating SN-38 injection compared with intravenous (IV) administration in a rabbit liver tumor model.
    Materials and Methods: In this animal care committee approved study, 18 rabbits (mean weight, 3.89 kg; range, 3.20-4.70 kg) with VX2 liver tumors were divided into two groups (IA and IV). Micellar nanoparticles incorporating SN-38 (30 mg/kg) were injected through the left hepatic artery in the IA group and the right femoral vein in the IV group. NK012 and free SN-38 in the plasma, liver parenchyma, and tumors were measured within 24 hours. Histologic examinations were conducted at 2 and 24 hours.
    Results: There were no significant differences in the serum area under the concentration time curve (0-24 h) for free SN-38, at 1,500 and 1,310 mu g.min/mL in the IA and TV groups, respectively (P = .152). The IA group showed significantly higher free SN-38 concentrations in tumor tissues at all time points compared with the IV group (P = .002 at 3 min, P = .011 at 2 h, and P = .047 at 24 h). Histologic findings showed that significantly higher tumor necrosis ratios were observed in the IA group compared with the IV group at 24 hours (P = .028).
    Conclusions: Micellar nanoparticles could be a promising IA drug delivery system to achieve high tumor tissue concentrations of SN-38.

    DOI: 10.1016/j.jvir.2016.10.032

    Web of Science

    PubMed

  6. Equivalent cross-relaxation rate imaging and diffusion weighted imaging for early prediction of response to bevacizumab-containing treatment in colorectal liver metastases - Preliminary Study Reviewed

    Shigeru Matsushima, Takeshi Sato, Hideyuki Nishiofuku, Yozo Sato, Shinichi Murata, Yasutomi Kinosada, Seiichi Era, Yoshitaka Inaba

    Clinical Imaging   Vol. 41   page: 1-6   2017.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  7. Equivalent cross-relaxation rate imaging and diffusion weighted imaging for early prediction of response to bevacizumab-containing treatment in colorectal liver metastases-preliminary study Reviewed

    Shigeru Matsushima, Takeshi Sato, Hideyuki Nishiofuku, Yozo Sato, Shinichi Murata, Yasutomi Kinosada, Seiichi Era, Yoshitaka Inaba

    CLINICAL IMAGING   Vol. 41   page: 1 - 6   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER SCIENCE INC  

    Purpose: To evaluate and compare the usefulness of equivalent cross-relaxation rate (ECR) imaging (ECRI) and diffusion-weighted imaging (DWI) in the early prediction of the response of bevacizumab-containing treatments of colorectal liver metastases.
    Methods and material: Seven patients received bevacizumab-containing treatments for colorectal liver metastases. Serial magnetic resonance imaging was performed to evaluate responses before and 2 weeks after starting chemotherapy. In the ECRI, we adopted the off-resonance technique for preferential saturation of immobile protons to evaluate the ECR values. A single saturation transfer pulse frequency was used at a frequency of 3.5 ppm downfield from the water resonance. In the DWI, the apparent diffusion coefficient (ADC) value commonly used with two b-values was acquired by using diffusion weightings of 0 and 800 s/mm(2). The region of interest of the metastatic lesions in the liver was separately measured by ECRI and DWI. Tumor response was assessed by response evaluation criteria in solid tumors criteria 8 weeks after starting chemotherapy.
    Results: In this study, we had four responders and three nonresponders. There was a significant difference in the pretreatment ECR values between the responders and nonresponders (P=.01); there was no significant difference in the ADC values between the two groups. Analysis of the percentage difference between the pretreatment and post-treatment values, termed as percentage change, showed that there were no significant differences in the percentage change of the ADC values between both groups; however, the percentage change in the ECR value was significantly greater for the responders than for the nonresponders (-41.6% 17.1% vs. -12.9%+/- 6.9%, respectively; P=.04).
    Conclusion: The pretreatment ECR value and percentage change of the ECR value 2 weeks after starting chemotherapy were useful parameters in the early prediction of response to bevacizumab-containing treatment in colorectal liver metastases. (C) 2016 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.clinimag.2016.08.013

    Web of Science

    PubMed

  8. Intraarterial Therapy Using Micellar Nanoparticles Incorporating SN-38 in a Rabbit Liver Tumor Model Reviewed

    Hideyuki Nishiofuku, Toshihiro Tanaka, Yasushi Fukuoka, Takeshi Sato, Tetsuya Masada, Shota Tatsumoto, Masayuki Sho, Ichiro Yamato, Satoshi Yasuda, Shigeru Matsushima, Masato Takano, Chiho Ohbayashi, Kimihiko Kichikawa

    J Vasc Interv Radiol   Vol. 28 ( 3 ) page: 457-464   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

  9. Preoperative Evaluation of Posthepatectomy Liver Failure Using MRI-Based Liver Function Indices in Child-Pugh Class A Reviewed

    Shigeru Matsushima, Yozo Sato, Hidekazu Yamaura, Mina Kato, Yui Onoda, Shinichi Murata, Yoshihiro Shimizu, Yasutomi Kinosada, Hideyuki Nishiofuku, Yoshitaka Inaba

    Open Journal of Radiology   Vol. 6   page: 147-156   2016

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  10. Preoperative estimation of future remnant liver function following portal vein embolization using relative enhancement on Gd-EOB-DTPA-enhanced magnetic resonance imaging Reviewed

    Yozo Sato, Shigeru Matsushima, Yoshitaka Inaba, Tsuyoshi Sano, Hidekazu Yamaura, Mina Kato, Yasuhiro Shimizu, Yoshiki Senda, Tsuneo Ishiguchi

    Korean Journal of Radiology   Vol. 16 ( 3 ) page: 523-530   2015

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    Language:English   Publishing type:Research paper (scientific journal)  

  11. New whole-body multimodality imaging of gastric cancer peritoneal metastasis combining fluorescence imaging with ICG-labeled antibody and MRI in mice Reviewed

    Akihiro Ito, Yuichi Ito, Shigeru Matsushima, Daisuke Tsuchida, Mai Ogasawara, Junichi Hasegawa, Kazunari Misawa, Eisaku Kondo, Norio Kaneda, Hayao Nakanishi

    Gastric Cancer   Vol. 17 ( 3 ) page: 497-507   2014.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  12. Equivalent cross-relaxation rate imaging positively correlates with pathological grade and cell density of adipocytic tumors Reviewed

    Okuda H, Matsushima S, Sugiura H, Yamada K, Hamada S, Nishida Y, Ishiguro N.

    Magn Reson Imaging   Vol. 32 ( 3 ) page: 206-210   2014.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  13. Visualization of liver uptake function using the uptake contrast-enhanced ratio in hepatobiliary phase imaging Reviewed

    Shigeru Matsushima, Yozo Sato, Hidekazu Yamaura, Mina Kato, Yasutomi Kinosada, Seiichi Era, Kazuya Takahashi, Yoshitaka Inaba

    Magn Reson Imaging   Vol. 32 ( 6 ) page: 654-659   2014

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  14. Correlation between equivalent cross-relaxation rate and cellular density in soft tissue tumors Reviewed

    Shunsuke Hamada, Shigeru Matsushima, Hideshi Sugiura, Kenji Yamada, Yoshihiro Nishida, Naoki Ishiguro

    Skeletal Radiology   Vol. 43 ( 2 ) page: 141-147   2014

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    Language:English   Publishing type:Research paper (scientific journal)  

  15. Evaluation of parotid gland function using equivalent cross-relaxation rate imaging applied magnetization transfer effect Reviewed

    Hidetoshi Shimizu, Shigeru Matsushima, Yasutomi Kinosada, Hiroki Miyamura, Takashi Kubota, Hikaru Osaki, Masashi Nakayama, Manabu Yoshimoto, Takeshi Kodaira

    Journal of Radiation Research   Vol. 53   page: 138-144   2012

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    Language:English   Publishing type:Research paper (scientific journal)  

  16. Cellular Imaging Using Equivalent Cross-Relaxation Rate Technique in Rabbit VX-2 Tumor Model Reviewed

    Hideyuki Nishiofuku, Shigeru Matsushima, Osamu Taguchi, Yoshitaka Inaba, Hidekazu Yamaura, Yozo Sato, Toshihiro Tanaka and Kimihiko Kichikawa

    Cancer Informatics   Vol. 10   page: 227-232   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

  17. Comparative intermolecular cross-relaxation studies of human hemoglobin in red blood cells and bovine serum albumin in solution Reviewed

    Seiichi Era, Masaru Sogami, Nobuhiro Uesaka, Masataka Murakami, Shigeru Matsushima, Yasutomi Kinosada

    NMR Biomed   Vol. 24   page: 483-491   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

  18. Comparative 1H NMR studies of saturation transfer in copolymer gels and mouse lenses Reviewed

    Koji Nakamura, Masaru Sogami, Seiichi Era, Shigeru Matsushima, Yasutomi Kinosa

    NMR Biomed.   Vol. 23 ( 6 ) page: 584-591   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

  19. Cell-Weighted Imaging for Malignant Lymphoma Using Equivalent Cross-Relaxation Rate Imaging Reviewed

    Hideyuki Nishiofuku, Shigeru Matsushima, Yoshitaka Inaba, Hidekazu Yamaura, Yozo Sato, Yasuo Morishima, Kimihiko Kichikawa

    Korean Journal of Radiology   Vol. 11 ( 3 ) page: 327-332   2010

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    Language:English   Publishing type:Research paper (scientific journal)  

  20. Changes in water content of intervertebral discs and paravertebral muscles before and after bed rest Reviewed

    Yoshihiro Matsumura, Yuichi Kasai, Hideaki Obata, Shigeru Matsushima, Tadashi Inaba, Atsumasa Uchida

    J Orthop Sci.   Vol. 14 ( 1 ) page: 45-50   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

  21. Equivalent cross-relaxation rate imaging of axillary lymph nodes in breast cancer Reviewed

    Shigeru Matsushima, Hideyuki Nishiofuku, Hiroji Iwata, Seiichi Era, Yoshitaka Inaba, Yasutomi Kinosada

    J. Magn Reson Imaging   Vol. 27   page: 1278-1283   2008

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  22. Equivalent cross-relaxation rate image for sentinel lymph node biopsy in breast carcinoma Reviewed

    Shigeru Matsushima, Fumio Sasaki, Hidekazu Yamaura, Hiroji Iwata, Hikaru Ohsaki, Seiichi Era, Masaru Sogami, Tadashi Inaba, Mitsuhiro Uike, Yasutomi Kinosada

    Magn Reson Med   Vol. 54 ( 5 ) page: 1300-1304   2005

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  23. Equivalent Cross-Relaxation Rate Imaging of Breast Cancer Reviewed

    Sachiko Yuen, Kei Yamada, Yasutomi Kinosada, Shigeru Matsushima, Yasuhiko Nakano, Mariko Goto, Tsunehiko Nishimura

    Journal of Magnetic Resonance Imaging   Vol. 20   page: 56-65   2004

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    Language:English   Publishing type:Research paper (scientific journal)  

  24. Equivalent Cross-Relaxation Rate Image for Decreasing a False Negative Case of Sentinel Node Biopsy Reviewed

    Shigeru Matsushima, Shuhei Sarumaru, Daisuke Ohta, Seiichi Era, Masaru Sogami, Fumio Sasaki, Tadashi Inaba, Yasutomi Kinosada

    Magnetic Resonance Imaging   Vol. 21 ( 9 ) page: 1045-1047   2003

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  25. Equivalent Cross-Relaxation Rate imaging in the Synthetic Copolymer Gels and Invasive Ductal Carcinomas of the Breast Reviewed

    Shigeru Matsushima, Akinori Takasu, Yoshihito Inai, Tadamichi Hirabayashi, Seiichi Era, Masaru Sogami, Fumio Sasaki, Hikaru Ohsaki, Yasutomi Kinosada

    Magnetic Resonance Imaging   Vol. 20   page: 285-293   2002

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  26. Equivalent Cross-Relaxation Rate in Magnetic Resonance Imaging: A Novel Physical Parameter for Evaluation of Conditions of water in Synthetic Copolymer Gels Reviewed

    Shigeru Matsushima, Akinori Takasu, Yoshihito Inai, Tadamichi Hirabayashi, Seiichi Era, Masaru Sogami, Yasutomi Kinosada

    Polymer journal   Vol. 33 ( 3 ) page: 236-241   2001

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  27. Basic studies on the equivalent cross-Relaxation rate imaging Reviewed

    Masaru Sogami, Seiichi Era, Yasutomi Kinosada, Shigeru Matsushima, Kazuo Kato,Mihoko Tomida and Tadamichi Hirabayashi

    NMR Biomed   Vol. 14   page: 367-375   2001

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    Language:English   Publishing type:Research paper (scientific journal)  

  28. Saturation transfer ratio in magnetic resonance imaging: A novel physical parameter for evaluation of hydrophilicity of synthetic copolymer gel Reviewed

    Shigeru Matsushima, Akinori Takasu, Yoshihito Inai, Tadamichi Hirabayashi, Seiichi Era, Masaru Sogami, Yasutomi Kinosada

    Polymer journal   Vol. 32 ( 10 ) page: 828-883   2000

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  29. Saturation transfer ratio imaging in invasive ductal carcinomas of the breast Reviewed

    Shigeru Matsushima, Fumio Sasaki, Yasutomi Kinosada, Hisatoshi Maeda, Masaru Sogami, Seiichi Era, Yasushi Yatabe, Shigeto Miura, Hikaru Ohsaki, Junichi Sakamoto

    Magnetic Resonance Imaging   Vol. 18   page: 379-385   2000

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  30. Tissue Characterization by Magnetization Transfer Ratio : Evaluated of MTRs in Breast tumors, Globus Pallidus and Nazopharyngeal tumors Reviewed

    S Matsushima, F Sasaki, Y Uchiyama, N Fuwa, M Andou, H Maeda, Y Kinosada

    Jpn Med Phys   Vol. 17   page: 1-8   1997

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  31. An external reference 1H spectroscopy Reviewed

    H.Maeda, S. Matsushima, I.Taki, M.Ohno, S. Takeuchi, Y. Ando

    Magn. Reson. Imaging   Vol. 6   page: 1067-1072   1996

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    Language:English   Publishing type:Research paper (scientific journal)  

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Presentations 14

  1. MRIで病理を探る Invited

    松島秀

    第77回日本放射線技術学会総会学術大会  2021.4.17  日本放射線技術学会

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    Event date: 2021.4

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:横浜   Country:Japan  

  2. The correlation between histomorphometry and relative tumor enhancement images by the texture analysis in colorectal liver metastases Invited International conference

    S Matsushima, S Murata, Y Sato, H Onaya, H Yamaura, M Kato, T Hasegawa, H Ogura, Y Inaba.

    2020 European Congress of Radiology  2020  European Congress of Radiology

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    Event date: 2020.7

    Language:English   Presentation type:Poster presentation  

    Venue:Vienna   Country:Austria  

    DOI: 10.26044/ecr2020/C-01196

  3. The relative tumor enhancement based on tumor heterogeneity for prediction of response to bevacizumab-containing treatment in liver metastases of colorectal cancer International conference

    S Matsushima, S Murata, Y Sato, H Onaya, H Yamaura, M Kato, T Hasegawa, Y Kinosada, Y Inaba

    2019 European Congress of Radiology 

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    Event date: 2019.2 - 2019.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  4. The relative liver enhancement on hepatobiliary phase imaging for prediction of response to bevacizumab-containing treatment in liver metastases of colorectal cancer International conference

    S Matsushima, S Murata, Y Sato, H Yamaura, Y Onoda, T Hasegawa, Y Kinosada, S Era, Y Inaba

    2018 European Congress of Radiology 

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    Event date: 2018.2 - 2018.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  5. Equivalent cross-relaxation rate imaging and diffusion-weighted imaging for early prediction of response to bevacizumab-containing treatment in colorectal liver metastases International conference

    S Matsushima, T Sato, H Nishiofuku, Y Sato, S Murata, Y Kinosada, S Era, Y Inaba

    2017 European Congress of Radiology 

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  6. Correlation of indocyanine green clearance and MRI-based heterogeneous liver function indices in Child-pugh class A patients International conference

    S Matsushima, Y Sato, H Yamaura, Y Onoda, M Kato, S Murata, Y Kinosada, S Era, Y Inaba

    2016 European Congress of Radiology 

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    Event date: 2016.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  7. Correlation of international normalized ratios after postoperative day 5 and MRI-based heterogeneous liver function indices in Child-pugh class A International conference

    S Matsushima, Y Sato, H Yamaura, Y Onoda, M Kato, S Murata, Y Kinosada S Era, Y Inaba

    2016 European Congress of Radiology 

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    Event date: 2016.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  8. Prediction of posthepatectomy liver failure using the coefficient variation of relative liver enhancement on hepatobiliary phase images International conference

    S. Matsushima, Y. Sato, H. Yamaura, M. Kato, S. Murata, Y. Kinosada, S. Era, Y. Yonezawa, H. Ogura, Y. Inaba

    2015 European Congress of Radiology 

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    Event date: 2015.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  9. Preoperative evaluation of future remnant liver function by the coefficient variation of contrast enhanced ratio in hepatocellular image International conference

    S.Matsushima, Y. Sato, H. Yamaura, M. Kato, Y. Kinosada, S. Era, Kazuya Takahashi, Y Inaba

    Radiological Society of North America 100nd Scientific Assembly and Annual Meeting 

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    Event date: 2014.11 - 2014.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  10. Correlation of hepatocellular density and contrast enhance ratio in hepatocellular of the surrounding non-cancerous background liver tissue International conference

    S.Matsushima, Y. Sato, H. Yamaura, M. Kato, D Inoue Y. Kinosada, S. Era, T.Kurinobu, Kazuya Takahashi, Y Inaba

    Society of North America 98nd Scientific Assembly and Annual Meeting. 

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    Event date: 2012.11

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  11. Correlation of hepatocellular density and the contrast enhance ratio in hepatocellular imaging. International conference

    S. Matsushima, Y. Sato, H. Yamaura, M. Kato, D. Inoue, Y. Kinosada, S. Era, K. Takahashi, Y. Inaba

    2012 European Congress of Radiology 

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    Event date: 2012.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  12. Evaluation of future remnant liver function by the contrast enhanced ratio in hepatocellular imaging International conference

    S.Matsushima, Y. Sato, H. Yamaura, M. Kato, Y. Kinosada, S. Era, H. Shimizu, Y Inaba

    Radiological Society of North America 97nd Scientific Assembly and Annual Meeting 

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    Event date: 2011.11 - 2011.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

  13. Preoperative evaluation of future remnant liver function by the contrast enhance ratio in hepatocellular image International conference

    S. Matsushima, Y. Sato, H. Yamaura, M. Kato, T. Kanamoto, Y. Kinosada, S. Era, H. Koyanagi, Y. Inaba

    2011 European Congress of Radiology 

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    Event date: 2011.3

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  14. The correlation between liver function and contrast enhanced ratio in the hepatocellular image International conference

    S.Matsushima, Y. Sato, H. Yamaura, Y. Kinosada, S. Era, Y Inaba

    Radiological Society of North America 96nd Scientific Assembly and Annual Meeting 

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    Event date: 2010.11 - 2010.12

    Language:English   Presentation type:Poster presentation  

    Country:United States  

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Research Project for Joint Research, Competitive Funding, etc. 10

  1. 腫瘍内血管内皮細胞増殖因子(VEGF)を可視化するための基礎的研究

    2019.4 - 2020.3

    公益財団法人がん研究振興財団がん研究助成金 

    松島 秀

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    Grant type:Competitive

  2. Oncology Imagingに有用なMRI細胞イメージングの開発

    2016.4 - 2017.3

    がんその他の悪性新生物研究助成金 

    松島 秀

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    Grant type:Competitive

  3. 肝細胞イメージを用いた残肝機能予測

    2011.4 - 2012.3

    がんその他の悪性新生物研究助成金 

    松島 秀

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    Grant type:Competitive

  4. 肝細胞イメージを用いたMR-volumetory法の開発

    2010.4 - 2011.3

    がんその他の悪性新生物研究助成金 

    松島 秀

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    Grant type:Competitive

  5. MRIによる肝細胞イメージと肝機能との相関性

    2009.4 - 2010.3

    がんその他の悪性新生物研究助成金 

    松島 秀

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    Grant type:Competitive

  6. MR-Cellular image による乳癌術前化学療法の早期治療効果判定

    2008.4 - 2029.3

    がんその他の悪性新生物研究助成金 

    松島 秀

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    Grant type:Competitive

  7. 肝細胞癌患者における個別化医療を目指したMR-Cellular imaging

    2007.4 - 2008.3

    がんその他の悪性新生物研究助成金 

    松島 秀

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    Grant type:Competitive

  8. Equivalent cross relaxation image によるmolecular lymph node imaging

    2006.4 - 2007.3

    がんその他の悪性新生物研究助成金 

    松島 秀

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    Grant type:Competitive

  9. Equivalent cross relaxation image による乳癌腋窩リンパ節転移の評価

    2005.4 - 2006.3

    がんその他の悪性新生物研究助成金 

    松島 秀

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    Grant type:Competitive

  10. 乳癌センチネルリンパ節生検の儀陰性症例を減少させるためのMRI

    2004.4 - 2005.3

    がんその他の悪性新生物研究助成金 

    松島 秀

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    Grant type:Competitive

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KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 標的分子に基づいたMR oncology imagingの開発

    2019.4

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  2. MRI分子イメージングによる分子標的薬における反応生の早期評価と肝機能の可視化

    2014.4 - 2018.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  3. The early evaluation of the responsiveness in molecular target drugs and the visualization of liver function by the MRI molecular imaging.

    Grant number:26461844  2014.4 - 2018.3

    Matsushima Shigeru

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    Authorship:Principal investigator 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    The purpose of this work is to perform the reactant early evaluation in molecular target drugs, and an exploitation of a surgery support liver-function imaging using MRI. To evaluate and compare the usefulness of equivalent cross-relaxation rate (ECR) imaging (ECRI) in the early prediction of the response of molecular target drugs treatments of colorectal liver metastases. In the response assessment to chemotherapy, the pretreatment ECR values were significantly higher in the responders group than in the non-responders group, and the 2 weeks after the ECR values were significantly lower. To evaluate posthepatectomy liver failure using gadoxetic acid-enhanced MRI with a measure of relative liver enhancement image (RLEI) on hepatobiliary phase images, thereby facilitating safe liver resection. This MRI examination method also provides morphological and functional information that can be used to optimize the preoperative selection of patients who can safely undergo liver resection.

  4. Pharmacokinetics and pharmacodynamics evaluation of micellar nanoparticles incorporating SN-38 using molecular imaging

    Grant number:26461833  2014.4 - 2018.3

    NISHIOFUKU HIDEYUKI

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

    Purpose: To evaluate the pharmacokinetics of intraarterial (IA) administration of micellar nanoparticles incorporating SN-38 (NK012) injection compared with intravenous (IV) administration in a rabbit liver tumor model. Methods: 18 rabbits with VX2 liver tumors were divided into two groups. NK012 and free SN-38 in the plasma, liver parenchyma, and tumors were measured within 24 hours. Results: There were no significant differences in the serum area under the concentration-time curve for free SN-38, at 1,500 and 1,310 μg*min/mL in the IA and IV groups, respectively. The IA group showed significantly higher free SN-38 concentrations in tumor tissues at all time points compared with the IV group. Histologic findings showed that significantly higher tumor necrosis ratios were observed in the IA group compared with the IV group at 24 hours. Conclusions: Micellar nanoparticles could be a promising IA drug delivery system to achieve high tumor tissue concentrations of SN-38.

  5. MRを用いた細胞密度画像によるがん化学療法の早期治療効果判定

    2010.4 - 2013.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  6. MRIを用いた腫瘍細胞密度を可視化する分子画像の開発と癌治療への応用

    2007.4 - 2009.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

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Industrial property rights 1

  1. 磁気共鳴イメージング装置及びその作動方法,画像診断システム並びに診断方法

    紀ノ定保臣,松島 秀,恵良聖一,長田真二

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    Application no:特願2009-534388  Date applied:2008.9

    Patent/Registration no:特許第5212951号  Date registered:2008.9 

    Country of applicant:Domestic