担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1136/bmjopen-2016-014878

DOI： 10.1136/bmjopen-2016-014878

PubMed

担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.atherosclerosis.2016.06.040

DOI： 10.1016/j.atherosclerosis.2016.06.040

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： http://dx.doi.org/10.1136/thoraxjnl-2015-206871

DOI： http://dx.doi.org/10.1136/thoraxjnl-2015-206871

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1097/PSY.0000000000000121

DOI： 10.1097/PSY.0000000000000121

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.1161/JAHA.114.001241

DOI： https://doi.org/10.1161/JAHA.114.001241

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.2188/jea.JE20110109

DOI： https://doi.org/10.2188/jea.JE20110109

担当区分：筆頭著者  

DOI： 10.1007/s11325-009-0319-6.

DOI： 10.1007/s11325-009-0319-6.

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Epidemiology  

Background: Environmental and genetic factors are suggested to exhibit factor-based association with HDL-cholesterol (HDL-C) levels. However, the population-based effects of environmental and genetic factors have not been compared clearly. We conducted a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study to evaluate the population-based impact of smoking, drinking, and genetic factors on low HDL-C. Methods: Data from 11,498 men and women aged 35–69 years were collected for a genome-wide association study (GWAS). Sixty-five HDL-C-related SNPs with genome-wide significance (P <5×10−8) were selected from the GWAS catalog, of which seven representative SNPs were defined, and the population-based impact was estimated using population attributable fraction (PAF). Results: We found that smoking, drinking, daily activity, habitual exercise, egg intake, BMI, age, sex, and the SNPs CETP rs3764261, APOA5 rs662799, LIPC rs1800588, LPL rs328, ABCA1 rs2575876, LIPG rs3786247, and APOE rs429358 were associated with HDL-C levels. The gene-environmental interactions on smoking and drinking were not statistically significant. The PAF for low HDL-C was the highest in men (63.2%) and in rs3764261 (31.5%) of the genetic factors, and the PAFs of smoking and drinking were 23.1% and 41.8%, respectively. Conclusion: The present study showed that the population-based impact of genomic factor CETP rs3764261 for low HDL-C was higher than that of smoking and lower than that of drinking.

DOI： 10.2188/jea.JE20210142

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：一般社団法人 日本動脈硬化学会  

DOI： 10.5551/jat.63675

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：日本運動疫学会  

DOI： 10.24804/ree.2154

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Sleep Health  

Objectives: Previous studies using objective parameters have shown that irregular sleep is associated with the disease incidence, progression, or mortality. This study aimed to determine the association between subjective sleep duration and sleep regularity, with mortality in a large population. Methods: Participants were from the Japan Multi-Institutional Collaborative Cohort study. We obtained information from each participant on sleep duration, sleep regularity, and demographics and overall lifestyle using self-administered questionnaires. We defined sleep regularity according to participants' subjective assessment of sleep/wake time regularity. Participants (n = 81,382, mean age: 58.1 ± 9.1years, males: 44.2%) were classified into 6 groups according to sleep duration and sleep regularity. Hazard ratios (HR) for time-to-event of death were calculated using the Cox proportional hazards model. Results: The mean follow-up period was 9.1 years and the mean sleep duration was 6.6 h/day. Irregular sleep significantly increased the risk of all-cause mortality in all models compared with regular sleep (HR 1.30, 95% confidence interval; CI, 1.18-1.44), regardless of sleep duration. Multivariable analysis of the 6 groups by sleep pattern (sleep regularity and duration) showed irregular sleep and sleep durations of <6 h/day, 6 to <8 h/day, or ≥8 h/day were associated with a 1.2-1.5-fold increases in mortality, compared to regular sleep and sleep duration of 6 to <8 h/day. Conclusions: Our study shows an association between sleep irregularity and all-cause mortality in a large Japanese population. Our findings provide further confirmation of the need to consider not only sleep duration, but also the regularity aspect of sleep schedules.

DOI： 10.1016/j.sleh.2022.08.010

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Sleep Medicine  

Objective: Findings on the increased mortality risk in individuals with insomnia are inconsistent across studies. Rather than improving insomnia by sleep control, hypnotic use may be one factor in the increased risk of death; however, the effects of hypnotics on mortality remains unclear. This study aimed to examine the association between all-cause mortality and hypnotic use in a large sample, while adjusting for the effects of comorbidities. Methods: Overall, 92,527 individuals aged 35–69 years were followed up for mortality in the Japan Multi-Institutional Collaborative Cohort Study. Regular use of hypnotics was assessed using a self-administered questionnaire. Since cancer history carries a substantial risk of death and is associated with the treatment of insomnia with hypnotics, participants with a cancer history were excluded. The hazard ratio (HR) and 95% confidence interval (CI) for all-cause mortality related to hypnotic use were estimated using a Cox proportional hazard model with adjustments for covariates including sleeping hours and comorbidities (body mass index, ischemic heart disease, stroke, and diabetes). Results: During the follow-up (mean, 8.4 ± 2.5 years), 1,492 mortalities were recorded, and the prevalence of taking hypnotics was 4.2%. Hypnotic use was associated with significantly greater risk of all-cause mortality, even after adjustment for the covariates (HR, 1.32; 95% CI, 1.07–1.63). The association between hypnotic use and all-cause mortality was robust in males (HR, 1.51; 95% CI, 1.15–1.96), and participants aged <60 years (HR, 1.75; 95% CI, 1.21–2.54). Conclusions: Our study revealed sex-age specific associations between hypnotic use and all-cause mortality.

DOI： 10.1016/j.sleep.2022.09.020

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：European Journal of Clinical Nutrition  

Background/objectives: Low-carbohydrate diets (LCD) are useful for weight reduction, and 50–55% carbohydrate consumption is associated with minimal risk. Genetic differences were related to nutritional consumption, food preferences, and dietary patterns, but whether particular genetic differences in individuals influence LCD adherence is unknown. Subjects/methods: We conducted a GWAS on adherence to LCD utilizing 14,076 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a previously validated semiquantitative food frequency questionnaire to estimate food consumption. Association of the imputed variants with the LCD score by Halton et al. we used linear regression analysis adjusting for sex, age, total dietary energy consumption, and components 1 to 10 by principal component analysis. We repeated the analysis with adjustment for alcohol consumption (g/day) in addition to the above-described variables. Results: Men and women combined analysis without adjustment for alcohol consumption; we found 395 variants on chromosome 12 associated with the LCD score having P values <5 × 10−8. A conditional analysis with the addition of the dosage data of rs671 on chromosome 12 as a covariate, P values for all 395 SNPs on chromosome 12 turned out to be insignificant. In the analysis with additional adjustment for alcohol consumption, we did not identify any SNPs associated with the LCD score. Conclusion: We found rs671 was inversely associated with adherence to LCD, but that was strongly confounded by alcohol consumption.

DOI： 10.1038/s41430-022-01090-w

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PLoS ONE  

Purpose The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population. Methods We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35–69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined. Results During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04–2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78–1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05). Conclusion MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.

DOI： 10.1371/journal.pone.0269550

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：International Journal of Behavioral Medicine  

Objective: The present study investigated associations between occupation, job stress, and salivary cortisol levels after psychological tasks. Methods: We examined 766 (273 men and 493 women) healthy employed Japanese participants aged 21 to 68 years (mean age = 46.4 years, standard deviation = 8.5) with three types of occupation: manager, teacher, and general worker. The Brief Job Stress Questionnaire was used to evaluate participants’ job stress levels, including job demand, job control, support from supervisors, and support from coworkers. Salivary cortisol levels were measured at pre-session, post-stressful tasks, and post-relaxation. All samples were assayed using an enzyme-linked immunosorbent assay test. Natural log transformation was applied before statistical analyses. A multiple regression analysis and a repeated measures analysis of covariance were conducted to test associations between occupation and salivary cortisol levels, adjusting for confounding factors. Statistical analyses were conducted separately for men and women. Results: Among both men and women, general workers had higher cortisol levels than managers throughout the experimental session (men 0.6 μg/dL and 0.4 μg/dL, respectively; women 0.5 μg/dL and 0.4 μg/dL, respectively). Job control was positively associated with cortisol levels measured in all sessions, after adjusting for confounding factors (standardized beta 0.15, 0.21, and 0.18 for pre-session, post-stressful-tasks, and post-relaxation, respectively, all p < 0.05). Men with low support from coworkers had higher cortisol levels than those with high support through the sessions (0.6 μg/dL and 0.4 μg/dL, respectively). Conclusion: Socioeconomic disparity according to occupational status was related to cortisol levels in Japanese workers. Support from coworkers may be effective for reducing cortisol secretion in men.

DOI： 10.1007/s12529-021-10020-2

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その他リンク： https://link.springer.com/article/10.1007/s12529-021-10020-2/fulltext.html

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Hypertension Research  

Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status. We evaluated the association of reproductive history with hypertension and obesity using a large cross-sectional dataset from the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). At the baseline survey, physical data, blood samples, and self-reported health questionnaires were collected. Participants with insufficient data were excluded, and 24,558 women from eight study regions were included in this study. Logistic regression analysis was conducted to evaluate the association of reproductive history with hypertension and obesity using multivariable-adjusted odds ratios. In premenopausal women, childbirth showed a generally protective effect on hypertension but not on obesity. In postmenopausal women, childbirth was positively associated with obesity and hypertension but not with hypertension after adjusting for BMI. In conclusion, reproductive history was associated with hypertension and obesity in a large Japanese population, and this association differed between premenopausal and postmenopausal women.

DOI： 10.1038/s41440-021-00820-0

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Oncology Letters  

Previous studies have investigated the usefulness of microRNA (miRNA/miR) expression data for the early detec- tion of colorectal cancer (CRC). However, limited data are available regarding miRNAs that detect CRC before clinical diagnoses. Accordingly, the present study investigated the early detectability of CRC by miRNAs using the preserved serum samples of the cohort participants affected with CRC within 2 years of study enrollment. First, the significant miRNAs were revealed using clinical CRC samples for a (seven early CRCs and seven controls) microarray analysis based on significance analysis of microarrays. Next, replica- bility was verified by reverse transcription-quantitative (RT-q) PCR (eight early CRCs and eight controls, together with 12 CRCs and 12 controls). Finally, early detectability was tested using the cohort samples of Japan Multi-Institutional Collaborative Cohort Study (17 CRCs and 17 controls) to reveal how a certain number of patients developed CRC within 2 years after participation. In the discovery phase, miRNA expression measurements were conducted using a 3D-Gene Human miRNA Oligo Chip for 2,555 miRNAs, and RT-qPCR analyses were performed to validate the replicability. In the first validation set with eight CRCs with early clinical stage and eight age- and gender-matched controls, miR-26a-5p and miR-223-3p demonstrated the highest diagnostic accu- racy of area under the curve (AUC)=1.000 (sensitivity and specificity 100%). In an examination of the predictability of CRC incidence using pre-clinical cohort samples, miR-26a-5p demonstrated good predictability of advanced CRC incidence with an AUC of 0.840. Overall, the present study revealed serum miR-26a-5p as a potential early detection marker for CRC.

DOI： 10.3892/ol.2022.13207

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PLoS ONE  

Objective The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. Methods The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Results Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose–response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ?4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ?55 years old. Conclusions Breastfeeding history may be related to lower prevalence of metabolic syndrome in middleaged parous women.

DOI： 10.1371/journal.pone.0262252

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Journal of Epidemiology  

Background: The Japan Multi-institutional Collaborative Cohort (J-MICC) study was launched in 2005 to examine gene–environment interactions in lifestyle-related diseases, including cancers, among the Japanese. This report describes the study design and baseline profile of the study participants. Methods: The participants of the J-MICC Study were individuals aged 35 to 69 years enrolled from respondents to study announcements in specified regions, inhabitants attending health checkup examinations provided by local governments, visitors at health checkup centers, and first-visit patients at a cancer hospital in Japan. At the time of the baseline survey, from 2005 to 2014, we obtained comprehensive information regarding demographics, education, alcohol consumption, smoking, sleeping, exercise, food intake frequency, medication and supplement use, personal and family disease history, psychological stress, and female reproductive history and collected peripheral blood samples. Results: The baseline survey included 92,610 adults (mean age: 55.2 [standard deviation, 9.4] years, 44.1% men) from 14 study regions in 12 prefectures. The participation rate was 33.5%, with participation ranging from 19.7% to 69.8% in different study regions. The largest number of participants was in the age groups of 65–69 years for men and 60–64 years for women. There were differences in body mass index, educational attainment, alcohol consumption, smoking, and sleep duration between men and women. Conclusions: The J-MICC Study collected lifestyle and clinical data and biospecimens from over 90,000 participants. This cohort is expected to be a valuable resource for the national and international scientific community in providing evidence to support longer healthy lives.

DOI： 10.2188/jea.JE20200147

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Gerontology  

Introduction: Reduced tongue pressure is one of the causes of dysphagia. The purpose of this study was to investigate the relationship between dental findings and tongue pressure, and whether prosthetic treatment prevents reduced tongue pressure. Methods: This was a cross-sectional study. Participants were 745 community-dwelling adults and elderly persons in the Goto Islands in Nagasaki, who underwent a health checkup for residents in 2015 and 2016. Data were collected on gender; age; grip strength; hemoglobin; Creatinine (Cr); glycated hemoglobin (HbA1c); history of stroke; smoking, drinking, exercise, and walking habits; number of teeth; wearing of removable dentures; functional units of natural teeth (n-FTUs), fixed prostheses (nif-FTUs), and removable dentures (t-FTUs); and tongue pressure. The associations between each variable and tongue pressure were examined using multiple regression analysis. Next, those with 3 or fewer n-FTUs were selected, and differences in tongue pressure were compared between those with 3 or fewer nif-FTUs and those with 4 or more nif-FTUs, using a propensity score matching method. Results: Male gender, weak grip strength, low HbA1c, no drinking, and a low number of teeth were independent factors significantly associated with lower tongue pressure. Among participants with 3 or fewer n-FTUs, the 43 with 4 or more nif-FTUs showed significantly higher tongue pressure than the 43 with 3 or fewer nif-FTUs after propensity score matching, although the number of t-FTUs was not associated with tongue pressure. Discussion/Conclusion: Tooth loss was significantly associated with lower tongue pressure. It was suggested that fixed prosthesis treatment might prevent the reduction of tongue pressure, but removable dentures did not have such an effect.

DOI： 10.1159/000513599

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Human Cell  

Gout is a common type of acute arthritis that results from elevated serum uric acid (SUA) levels. Recent genome-wide association studies (GWASs) have revealed several novel single nucleotide polymorphism (SNPs) associated with SUA levels. Of these, rs10821905 of A1CF and rs1178977 of BAZ1B showed the greatest and the second greatest significant effect size for increasing SUA level in the Japanese population, but their association with gout is not clear. We examined their association with gout using 1411 clinically-defined Japanese gout patients and 1285 controls, and meta-analyzed our previous gout GWAS data to investigate any association with gout. Replication studies revealed both SNPs to be significantly associated with gout (P = 0.0366, odds ratio [OR] with 95% confidence interval [CI]: 1.30 [1.02–1.68] for rs10821905 of A1CF, P = 6.49 × 10–3, OR with 95% CI: 1.29 [1.07–1.55] for rs1178977 of BAZ1B). Meta-analysis also revealed a significant association with gout in both SNPs (Pmeta = 3.16 × 10–4, OR with 95% CI: 1.39 [1.17–1.66] for rs10821905 of A1CF, Pmeta = 7.28 × 10–5, OR with 95% CI 1.32 [1.15–1.51] for rs1178977 of BAZ1B). This study shows the first known association between SNPs of A1CF, BAZ1B and clinically-defined gout cases in Japanese. Our results also suggest a shared physiological/pathophysiological background between several populations, including Japanese, for both SUA increase and gout susceptibility. Our findings will not only assist the elucidation of the pathophysiology of gout and hyperuricemia, but also suggest new molecular targets.

DOI： 10.1007/s13577-021-00485-4

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その他リンク： http://link.springer.com/article/10.1007/s13577-021-00485-4/fulltext.html

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.1159/000513599

DOI： https://doi.org/10.1159/000513599

記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Nagoya Journal of Medical Science  

Prostate cancer is emerging as a significant global public health burden. The incidence and prevalence of prostate cancer has increased in Japan, as westernized lifestyles become more popular. Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with serum prostate-specific antigen (PSA) levels. One GWAS, which was based on classic GWAS microarray measurements, has been reported for Japanese so far. In the present study,we conducted a GWAS of serum PSA using 1000Genomes imputed GWAS data (n =1,216) from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, to detect candidate novel genetic loci that influence serum PSA levels in Japanese. The association of SNPs/genetic variants with serum PSA as a continuous variable was tested using the linear Wald test. SNP rs10000006 in SGMS2 (sphingomyelin synthase 2) on chromosome 4 had genome-wide significance (P <5×10∑8), and eight variants on three chromosomes (chromosomes 12, 14, 15) had genome-wide suggestive levels of significance (P <1×10∑6). With an independent data set from the J-MICC Shizuoka Study (n = 2,447), the association of the SGMS2 SNP with blood PSA levels was not replicated. Although our GWAS failed to detect novel loci associated with serum PSA levels in the Japanese cohort, it confirmed the significant effects of previously reported genetic loci on PSA levels in Japanese. Importantly, our results confirmed the significance of KLK3 SNPs also in Japanese, implying that consideration of individual genetic information in prostate cancer diagnosis may be possible in the future.

DOI： 10.18999/nagjms.83.1.183

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12877-020-01658-w

PubMed

その他リンク： https://link.springer.com/article/10.1186/s12877-020-01658-w/fulltext.html

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BMJ  

<sec><title>Background:</title>Anti-citrullinated protein antibody (ACPA) production is observed in several organs even prior to the onset of rheumatoid arthritis (RA), and oral mucosa is considered to be one of the important tissues. The presence of HLA-DRB1*SE closely associates with ACPA production. Saliva is considered to reflect the oral microbiota including periodontal disease. Alteration of oral microbiota of RA becomes to be normalized by DMARDs treatment, however, the interaction of HLA-DRB1*SE, ACPA and oral microbiota of RA patients remains to be elucidated.

</sec><sec><title>Objectives:</title>The Nagasaki Island Study, which had started in 2014 collaborating with Goto City, is intended for research of the preclinical stage of RA, including ACPA/HLA genotype screening and ultrasound and magnetic resonance imaging examinations in high-risk subjects. Using the samples accumulated in this cohort, we have tried to investigate the difference of oral microbiota among RA patients and healthy subjects regarding to ACPA and HLA-DRB1*SE.

</sec><sec><title>Methods:</title>Blood and salivary samples were obtained from 1422 subjects out of 4276 who have participated in the Nagasaki Island Study from 2016 to 2018. ACPA positivity was 1.7 % in total. Some of RA patients resided in Goto City participated in the Nagasaki Island Study. At this point, we selected 291 subjects, who were ACPA positive non-RA healthy subjects (n=22) and patients with RA (n=33, 11 subjects were ACPA positive and 22 ACPA negative respectively) as the case, age and gender matched ACPA negative non-RA healthy subjects (n=236) as the control. ACPA was measured by an enzyme-linked immunosorbent assay, and HLA genotyping was quantified by next-generation sequencing (Ref.1). The operational taxonomic unit (OUT) analysis using 16S rRNA gene sequencing were performed. The richness of microbial diversity within-subject (alpha diversity) was scaled via Shannon entropy. The dissimilarity between microbial community composition was calculated using Bray-Curtis distance as a scale, and differences between groups (beta diversity) were tested by permutational multivariate analysis of variance (PERMANOVA). In addition, UniFrac distance calculated in consideration of the distance on the phylogenetic tree were performed.

</sec><sec><title>Results:</title>Median age 70 y.o., % Female 58.8 %. Among RA and non-RA subjects, not alpha diversity but beta diversity was statistically significance (p=0.022, small in RA). In RA subjects, both alpha and beta diversity is small (p&lt;0.0001), especially significant in ACPA positive RA (Figure 1). Amongt RA subjects, presence of HLA-DRB1*SE did not show the difference but the tendency of being small of alpha diversity (p=0.29).

</sec><sec><title>Conclusion:</title>Our study has suggested for the first time the association of oral microbiota alteration with the presence of ACPA and HLA-DRB1*SE. Oral dysbiosis may reflect the immunological status of patients with RA.

</sec><sec><title>References:</title>[1]Kawaguchi S, et al. Methods Mol Biol 2018;1802: 22

</sec><sec><title>Disclosure of Interests:</title>None declared

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DOI： 10.1136/annrheumdis-2020-eular.5147

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/ggi.13657

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12199-019-0780-1

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.atherosclerosis.2019.02.004

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18632/aging.101768

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12199-018-0744-x

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.envres.2018.05.033

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.5551/jat.43125

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12199-018-0720-5

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1093/cid/ciy168

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/ggi.13312

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12199-018-0705-4

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/ggi.13166

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18632/oncotarget.23660

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/ggi.13152

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/ggi.13068

Web of Science

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12199-017-0684-x

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/ggi.12876

Web of Science

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18632/oncotarget.20618

Web of Science

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s40101-017-0143-9

Web of Science

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.atherosclerosis.2017.02.016

Web of Science

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： doi: 10.14283/jfa.2016.107

DOI： doi: 10.14283/jfa.2016.107

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s12199-017-0668-x

Web of Science

PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.1016/j.pmedr.2016.05.010

DOI： https://doi.org/10.1016/j.pmedr.2016.05.010

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1186/s40101-016-0084-8.

DOI： 10.1186/s40101-016-0084-8.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： doi: 10.1186/s40101-016-0085-7.

DOI： doi: 10.1186/s40101-016-0085-7.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18632/aging.101061

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s12199-016-0532-4.

DOI： 10.1007/s12199-016-0532-4.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.18632/oncotarget.10229

DOI： 10.18632/oncotarget.10229

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： https://doi.org/10.1016/j.psyneuen.2016.04.005

DOI： https://doi.org/10.1016/j.psyneuen.2016.04.005

J-GLOBAL

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

記述言語：日本語   掲載種別：研究発表ペーパー・要旨（全国大会，その他学術会議）   出版者・発行元：(一社)日本リウマチ学会  

担当区分：筆頭著者,　最終著者,　責任著者   記述言語：日本語   出版者・発行元：国立保健医療科学院  

地域の健康管理には、地域を把握するためのデータ収集・評価と、地域ぐるみで取り組むためのデータ活用が必要である。データ収集・評価では、取り組みの根拠を明確にするため、健康に関連する様々な情報を活用することが望ましい。大学と自治体が連携することで、疾病発症情報等様々な追加情報を得られることから、地域の疾病要因についての検証と評価が可能となる。また、大学が提供する分析結果を、行政や住民の強みを活かし伝わりやすい方法で示すことで、分野横断的な取り組みと、課題解決を後押しできると考えられる。本著では、大学が行う地域健診活動とコホート調査の調査手順について紹介し、地域で有用な情報を集める際の分野横断的な協働の必要性について説明した。また、自治体で入手しやすいデータの活用方法の工夫として、国保データベースシステム(KDB)データ・特定健診データの提示例と共に、公表機会の活用事例についても紹介した。分野横断的な協働の基盤となるのは、組織間や住民との信頼関係である。長崎大学と五島市の事例を通して重要であった活動基盤、視点と目標の共有、お互いの力が最大限に発揮できるよう情報提供し合える関係づくりについて説明した。(著者抄録)

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J03876&link_issn=&doc_id=20181122440004&doc_link_id=10.20683%2Fjniph.67.4_365&url=https%3A%2F%2Fdoi.org%2F10.20683%2Fjniph.67.4_365&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

記述言語：日本語   出版者・発行元：明治安田厚生事業団  

Andhra Pradesh Children and Parents Studyの第三次追跡調査およびNagasaki Islands Studyの2014〜2016年ベースライン調査参加者を対象とした。インドでは1501名、日本では3136名を解析した。インドでは、男性の割合が高く、年齢が若く、握力が男女ともに低く、頸動脈内膜中膜複合体厚(CIMT)も低く、高血圧症の割合が低かった。また、日本に比べて、HDLコレステロールが低く、中性脂肪が高く、中性脂肪/HDLコレステロール比が高値であった。インド男性でCIMT×高血圧症の有無を交互作用項とすると、CIMTと握力に負の関連を認めた。高血圧症での層別分析では、インドの非高血圧症男性でCIMTは握力と負の関連があった。インドの女性や日本のコホート集団においては有意な関連は認めなかった。年齢、BMI、収縮期血圧、空腹時血糖、総コレステロール、eGFR、アルブミン、脳卒中既往歴、虚血性心疾患既往歴、喫煙歴、飲酒歴、栄養摂取カロリー、蛋白摂取量、活動量を調整変数とした多変量解析で、インドのコホート集団でCIMTと四肢筋肉量との間に有意な関連は認めなかった。

CiNii Books

© 2018, Nagasaki University School of Medicine. All rights reserved. Aims: Slow walking speed in older subjects was reported to be associated with an increased risk of cardiovascular mortality. On the other hand, minor allele frequency of the single nucleotide polymorphism (SNP) rs3782886 is reported to be positively associated with coronary artery disease. Therefore, the rs3782886 genotype might be associated with walking speed later in life. However, no studies have reported on the influence of rs3782886 on walking speed in elderly subjects. Methods: To evaluate the influence of SNP rs3782886 on walking speed in later life, we conducted a cross-sectional study of 562 elderly women aged 60 years and over who had undertaken a general health check-up between 2014 and 2015. Faster walking speed was defined by a questionnaire which asked, “Do you walk faster than your contemporaries?” (yes, no). Results: Of the total study population, with regard to the rs3782886 genotype, 356 subjects showed major homo (A/A), 177 hetero (A/G) and 29 minor homo (G/G). Independent of known cardiovascular risk factors, with major homo as the reference group, the adjusted odds ratio and 95% confidence interval for faster walking speed were 0.92 (0.54, 1.58) for hetero and 0.39 (0.16, 0.97) for minor homo. Conclusion: Independent of classical cardiovascular risk factors, the SNP rs3782886 was found to be associated with faster walking speed, as defined by a questionnaire, in elderly Japanese women. This result represents an efficient tool to clarify the mechanism of rs3782886 as a risk factor for cardiovascular disease.

Scopus

J-GLOBAL

J-GLOBAL

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本内科学会  

BACKGROUND: Handgrip strength is a simple measurement of overall muscular strength and is used to detect sarcopenia. It also predicts adverse events in later life. Many mechanisms of sarcopenia development have been reported. A hypertensive status impairs endothelial dysfunction, which might deteriorate skeletal muscle if vascular angiogenesis is not maintained.OBJECTIVES: This study investigated muscle strength and circulating CD34-positive cells as a marker of vascular angiogenesis.DESIGN: Cross-sectional study.PARTICIPANTS: 262 male Japanese community dwellers aged 60 to 69 years.MEASUREMENTS: The participants&#039; handgrip strength, medical history, and blood samples were taken. We stratified the participants by hypertensive status to investigate the association between handgrip strength and circulating CD34-positive cells according to hypertensive status. Pearson correlation and linear regression analyses were used.RESULTS: In the Pearson correlation analysis, handgrip strength and the logarithm of circulating CD34-positive cells were significantly associated in hypertensive participants (r=0.22, p=0.021), but not in non-hypertensive participants (r=-0.01, p=0.943). This relationship was only significant in hypertensive participants (ß=1.94, p=0.021) in the simple linear regression analysis, and it remained significant after adjusting for classic cardiovascular risk factors (ß=1.92, p=0.020). The relationship was not significant in non-hypertensive participants (ß=-0.09, p=0.903).CONCLUSIONS: We found a positive association between handgrip strength and circulating CD34-positive cells in hypertensive men. Vascular maintenance attributed by circulating CD34-positive cells is thought to be a background mechanism of this association after hypertension-induced vascular injury in skeletal muscle.

DOI： 10.14283/jfa.2016.107

Scopus

PubMed

© 2017 Nagasaki University Library, All Right Reserved. Background: Although we reported in a previous study that diabetes with a high serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratio constitutes a risk for atherosclerosis, associations in terms of TG-HDL ratio between diabetes and gamma-glutamyltransferase (GGT), which is also known as an independent risk factor for atherosclerosis, have not yet been clarified. The purpose of this study was to test the hypothesis that a positive association between GGT and diabetes may be confined to high TG-HDL. Methods: This was a cross-sectional study of 2,302 Japanese subjects who were undergoing a general health check in 2014. All subjects were divided into TG-HDL level tertiles and serum GGT and diabetes status were investigated. Results: Of 207 diabetes patients identified in this study, 94 had high TG-HDL, 63 intermediate TG-HDL, and 50 low TG-HDL. Independent of classical cardiovascular risk factors, serum GGT showed a positive association with diabetes in patients with high TG-HDL, but not in patients with intermediate and low TG-HDL diabetes. The multivariable adjusted odds ratios (OR) and 95% coincidence intervals (95%CI) of diabetes for 1 standard deviation (SD) increment of GGT were 1.64 (95%CI: 1.16-2.31) for high TG-HDL, 1.46 (95%CI: 0.95-2.26) for intermediate TG-HDL, and 1.04 (95%CI: 0.60-1.79) for low TG-HDL diabetes. Conclusion: Serum GGT is positively associated with diabetes in patients with high TG-HDL but not with intermediate or low TG-HDL diabetes. This finding may prove to be an efficient tool for estimating atherosclerotic risk in diabetes patients.

Scopus

J-GLOBAL

開催年月日： 2021年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：オンライン  

開催年月日： 2021年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：オンライン  

開催年月日： 2020年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：オンライン  

開催年月日： 2019年1月 - 2019年2月

記述言語：日本語   会議種別：ポスター発表  

開催地：東京  

開催年月日： 2018年2月

記述言語：日本語   会議種別：ポスター発表  

開催地：福島  

開催年月日： 2017年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：鹿児島  

開催年月日： 2017年1月

記述言語：日本語   会議種別：ポスター発表  

開催地：甲府  

開催年月日： 2014年3月

記述言語：英語   会議種別：口頭発表（一般）  

開催年月日： 2014年3月

記述言語：英語   会議種別：口頭発表（一般）  

国名：アメリカ合衆国  

開催年月日： 2011年3月

国名：アメリカ合衆国  

開催年月日： 2023年2月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2022年6月 - 2022年7月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2022年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2022年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2022年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2021年3月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2021年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：オンライン  

開催年月日： 2021年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2021年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2021年1月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2020年6月

記述言語：英語   会議種別：口頭発表（一般）  

<sec><title>Background:</title>Anti-citrullinated protein antibody (ACPA) production is observed in several organs even prior to the onset of rheumatoid arthritis (RA), and oral mucosa is considered to be one of the important tissues. The presence of HLA-DRB1*SE closely associates with ACPA production. Saliva is considered to reflect the oral microbiota including periodontal disease. Alteration of oral microbiota of RA becomes to be normalized by DMARDs treatment, however, the interaction of HLA-DRB1*SE, ACPA and oral microbiota of RA patients remains to be elucidated.

</sec><sec><title>Objectives:</title>The Nagasaki Island Study, which had started in 2014 collaborating with Goto City, is intended for research of the preclinical stage of RA, including ACPA/HLA genotype screening and ultrasound and magnetic resonance imaging examinations in high-risk subjects. Using the samples accumulated in this cohort, we have tried to investigate the difference of oral microbiota among RA patients and healthy subjects regarding to ACPA and HLA-DRB1*SE.

</sec><sec><title>Methods:</title>Blood and salivary samples were obtained from 1422 subjects out of 4276 who have participated in the Nagasaki Island Study from 2016 to 2018. ACPA positivity was 1.7 % in total. Some of RA patients resided in Goto City participated in the Nagasaki Island Study. At this point, we selected 291 subjects, who were ACPA positive non-RA healthy subjects (n=22) and patients with RA (n=33, 11 subjects were ACPA positive and 22 ACPA negative respectively) as the case, age and gender matched ACPA negative non-RA healthy subjects (n=236) as the control. ACPA was measured by an enzyme-linked immunosorbent assay, and HLA genotyping was quantified by next-generation sequencing (Ref.1). The operational taxonomic unit (OUT) analysis using 16S rRNA gene sequencing were performed. The richness of microbial diversity within-subject (alpha diversity) was scaled via Shannon entropy. The dissimilarity between microbial community composition was calculated using Bray-Curtis distance as a scale, and differences between groups (beta diversity) were tested by permutational multivariate analysis of variance (PERMANOVA). In addition, UniFrac distance calculated in consideration of the distance on the phylogenetic tree were performed.

</sec><sec><title>Results:</title>Median age 70 y.o., % Female 58.8 %. Among RA and non-RA subjects, not alpha diversity but beta diversity was statistically significance (p=0.022, small in RA). In RA subjects, both alpha and beta diversity is small (p&lt;0.0001), especially significant in ACPA positive RA (Figure 1). Amongt RA subjects, presence of HLA-DRB1*SE did not show the difference but the tendency of being small of alpha diversity (p=0.29).

</sec><sec><title>Conclusion:</title>Our study has suggested for the first time the association of oral microbiota alteration with the presence of ACPA and HLA-DRB1*SE. Oral dysbiosis may reflect the immunological status of patients with RA.

</sec><sec><title>References:</title>[1]Kawaguchi S, et al. Methods Mol Biol 2018;1802: 22

</sec><sec><title>Disclosure of Interests:</title>None declared

</sec>

開催年月日： 2019年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2019年4月

記述言語：日本語   会議種別：ポスター発表  

開催地：京都  

開催年月日： 2019年1月 - 2019年2月

記述言語：日本語   会議種別：ポスター発表  

開催地：東京  

開催年月日： 2018年11月

記述言語：日本語   会議種別：ポスター発表  

開催地：軽井沢町  

開催年月日： 2018年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：郡山  

開催年月日： 2018年8月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：長崎  

開催年月日： 2018年7月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2018年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：津  

開催年月日： 2018年3月

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2018年2月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡  

開催年月日： 2018年

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：長崎  

開催年月日： 2018年

記述言語：日本語   会議種別：口頭発表（一般）  

開催年月日： 2017年10月 - 2017年11月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：鹿児島  

開催年月日： 2017年5月 - 2017年6月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：山形  

開催年月日： 2017年4月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：東京  

開催年月日： 2017年3月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：宮崎  

開催年月日： 2017年3月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：宮崎  

開催年月日： 2017年1月

記述言語：日本語   会議種別：ポスター発表  

開催地：甲府  

開催年月日： 2015年3月

記述言語：英語   会議種別：ポスター発表  

国名：アメリカ合衆国  

開催年月日： 2014年8月

記述言語：英語   会議種別：口頭発表（一般）  

開催年月日： 2012年3月

記述言語：英語   会議種別：ポスター発表  

国名：アメリカ合衆国  

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：横浜  

記述言語：日本語   会議種別：口頭発表（一般）  

記述言語：日本語   会議種別：口頭発表（一般）  

記述言語：日本語   会議種別：口頭発表（一般）  

Young Leaders Programに参加している留学生と対象とした疫学・生物統計の科目で、「Screening」に関する講義を行った。
また、SPSSを使った分析方法についての講義・実習に参加した。

医学部4年生を対象とした科目「疫学と予防医学」のうち「疾患予防と健康施策」に関する講義を行った。