Organization
Graduate School of Medicine Designated associate professor
Title
Designated associate professor
Contact information
External link
MIYAKE Yasuyuki
Degree 3
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Ph.D. （ 2006.3 Osaka University ）
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Master(Integrated Biosciences) （ 2002.3 The University of Tokyo ）
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BSc （ 2000.3 Shinshu University ）
Research Interests 6
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RNA virus
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Influenzavirus
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vRNPs
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ubiquitin
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HDAC6
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molecular structure
Research Areas 3
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Life Science / Molecular biology / Molecular Biology
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Life Science / Virology / Virology
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Life Science / Cell biology
Current Research Project and SDGs 1
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ウイルス感染における宿主因子の動態と分子機能の解明
Research History 7
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Nagoya University Graduate School of Medicine Assistant Professor
2020.4
Country：Japan
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University of Bristol School of Cellular and Molecular Medicine Researcher
2018.5 - 2020.3
Country：United Kingdom
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Nagoya University Graduate School of Medicine JSPS Research Fellow
2018.4 - 2020.3
Country：Japan
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Shinshu University Researcher
2016.4 - 2018.3
Country：Japan
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Friedrich Miescher Institute for Biomedical Research Epigenetics group Researcher
2010.3 - 2015.12
Country：Switzerland
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Kyoto University Graduate School of Biostudies Researcher
2006.4 - 2010.3
Country：Japan
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RIKEN Laboratory of Cellular Physiology Student Trainee
2002.4 - 2006.3
Country：Japan
Education 3
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Osaka University Graduate School, Division of Medical Sciences
- 2006.3
Country： Japan
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The University of Tokyo
- 2002.3
Country： Japan
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Shinshu University Faculty of Science Biological Science
- 2000.3
Country： Japan
Professional Memberships 3
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日本分子生物学会
2000.12
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日本ウイルス学会
2020.9
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日本細胞生物学会
2022.3
Awards 2
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Pfizer Forschungspreis (Infektiologie, Rheumatologie und Immunologie)
2016.1 Pfizer
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CMM Awayday Best Poster Prize
2019.1 University of Bristol Influenza virus uses transportin 1 for vRNP debundling during cell entry
Miyake Yasuyuki
Papers 9
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Influenza virus uses transportin 1 for vRNP debundling during cell entry Reviewed International coauthorship
Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, Kutay U, Helenius A, Yamauchi Y
Nature Microbiology Vol. 4 ( 4 ) page： 578 - 586 2019.4
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Structural insights into HDAC6 tubulin deacetylation and its selective inhibition Reviewed
Miyake Y, Keusch JJ, Wang L, Saito M, Hess D, Wang X, Melancon BJ, Helquist P, Gut H, Matthias P
Nature Chemical Biology Vol. 12 ( 9 ) page： 748 - 754 2016.9
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Influenza A virus uses the aggresome processing machinery for host cell entry Reviewed
Banerjee I, Miyake Y, Nobs SP, Schneider C, Horvath P, Kopf M, Matthias P, Helenius A, Yamauchi Y
Science Vol. 346 ( 6208 ) page： 473 - 477 2014.10
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RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway Reviewed
Miyake Y, Nakamura M, Nabetani A, Shimamura S, Tamura M, Yonehara S, Saito M, Ishikawa F
Molecular cell Vol. 36 ( 2 ) page： 193 - 206 2009.10
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Longlong Wang, Etori Aguiar Moreira, Georg Kempf, Yasuyuki Miyake, Blandina I. Oliveira Esteves, Amal Fahmi, Jonas V. Schaefer, Birgit Dreier, Yohei Yamauchi, Marco P. Alves, Andreas Plückthun, Patrick Matthias
Cell Reports Vol. 39 ( 4 ) page： 110736 - 110736 2022.4
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A STING inhibitor suppresses EBV‐induced B cell transformation and lymphomagenesis Reviewed
Shouhei Miyagi, Takahiro Watanabe, Yuya Hara, Masataka Arata, Md. Kamal Uddin, Keisuke Mantoku, Ken Sago, Yusuke Yanagi, Takeshi Suzuki, H. M. Abdullah Al Masud, Jun‐ichi Kawada, Shigeo Nakamura, Yasuyuki Miyake, Yoshitaka Sato, Takayuki Murata, Hiroshi Kimura
Cancer Science Vol. 112 ( 12 ) page： 5088 - 5099 2021.12
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Acetylation site specificities of lysine deacetylase inhibitors in human cells Reviewed International coauthorship
Schölz C, Weinert BT, Wagner SA, Beli P, Miyake Y, Qi J, Jensen LJ, Streicher W, McCarthy AR, Westwood NJ, Lain S, Cox J, Matthias P, Mann M, Bradner JE, Choudhary C
Nature biotechnology Vol. 33 ( 4 ) page： 415 - 423 2015.4
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Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus Reviewed
Eichinger CS, Mizuno T, Mizuno K, Miyake Y, Yanagi K, Imamoto N, Hanaoka F
The Journal of Biological Chemistry Vol. 284 ( 44 ) page： 30604 - 30614 2009.10
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Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation Reviewed
Miyake Y, Mizuno T, Yanagi K, Hanaoka F
The Journal of Biological Chemistry Vol. 280 ( 13 ) page： 12643 - 12652 2005.4
Books 3
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インフルエンザウイルスの細胞内侵入の生化学
三宅 康之, 山内 洋平（ Role： Joint author）
日本生化学会 2022.6
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Molecular function of host factors involved in cellular entry of influenza A virus
Yasuyuki Miyake（ Role： Sole author , Topics from special edition）
the New Science Co., Ltd. 2022.5
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Purification of Unanchored Polyubiquitin Chains from Influenza Virions
Miyake Yasuyuki, Matthias Patrick, Yamauchi Yohei（ Role： Contributor , Chapter 16）
Humana Press 2018 （ ISBN:978-1-4939-8677-4 ）
MISC 2
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重症ウイルス感染症／ウイルス関連腫瘍を制御するための宿主因子探索と創薬応用
佐藤好隆, 渡辺崇広, 三宅康之, 木村 宏
最先端ナノライフシステム研究 page： 24 - 29 2022.3
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ヒストン脱アセチル化酵素HDAC6の結晶構造から明らかにされたチューブリンに対する特異性および選択的な阻害剤との結合 Invited International coauthorship
三宅康之 , パトリック マティアス
ライフサイエンス新着論文レビュー 2016.8
Presentations 11
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ENDOSOMAL DEUBIQUITINASE USP7 PROMOTES INFLUENZA VIRUS UNCOATING International conference
Alina Rozanova, Takahiro Watanabe, Naoki Narita, Hiroshi Kimura, Yasuyuki Miyake, Yohei Yamauchi
Negative Strand Virus Meeting 2022 2022.6.13
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宿主タンパク質を介したウイルス脱殻反応の分子機構解明 International conference
原 優矢, 三宅 康之, 山内 洋平, 木村 宏
第69回日本ウイルス学会学術集会 2022.11.15
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Elucidating the interactions between Influenza A Matrix Protein M1 and host cell factor Transportin-1 during vRNP debundling International conference
2022.11.14
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Molecular mechanisms of uncoating in human coronavirus 229E International conference
2022.11.15
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USP7 promotes influenza A virus uncoating at late endosomes International conference
Alina Rozanova, Takahiro Watanabe, Naoki Narita, Yasuyuki Miyake, Yohei Yamauchi
2022.6.28
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HOW INFLUENZA A VIRUS MATRIX PROTEIN M1 INTERACTS WITH HOST CELL FACTOR TRANSPORTIN-1 DURING VRNP DEBUNDLING International conference
Atzin Ceron, Yasuyuki Miyake, Yohei Yamauchi, Hiroshi Kimura
Negative Strand Virus Meeting 2022 2022.6.13
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MOLECULAR MECHANISMS OF HUMAN CORONAVIRUS ENDOSOMAL UNCOATING International conference
Miki Umeda, Tatsuki Tanito, Yoshitaka Sato, Mark Marsh, Hiroshi Kimura, Yohei Yamauchi, Yasuyuki Miyake
Negative Strand Virus Meeting 2022 2022.6.12
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INSIGHTS INTO INFLUENZA A VIRUS VRNP DEBUNDLING International conference
Yuya Hara, Hiroshi Kimura, Yasuyuki Miyake, Yohei Yamauchi
Negative Strand Virus Meeting 2022 2022.6.13
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Molecular mechanism(s) for cellular entry of RNA viruses Invited
Yasuyuki Miyake
Premium Lecture 2021.11.18
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Molecular function of USP7 protein in cellular entry of influenza virus International coauthorship
Alina Rozanova, Yasuyuki Miyake, and Yohei Yamauchi
43th BMSJ 2020 2020.12.3
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宿主因子を標的とした新規抗ウイルス薬の探索に向けて Invited International conference
三宅康之
中部地区医療・バイオ系シーズ発表会 2021.12.7
Research Project for Joint Research, Competitive Funding, etc. 2
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ウイルス感染における宿主因子の動態と分子機能の解明
2021.4 - 2024.3
科学技術振興機構 創発的研究支援事業
Grant type：Competitive
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The HDAC6/USP7 axis in enveloped RNA virus infection
2019.12 - 2023.3
Yasuyuki Miyake
Grant type：Competitive
KAKENHI (Grants-in-Aid for Scientific Research) 4
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ウイルス感染における宿主因子の動態と分子機能の解明
2021.4 - 2024.3
科学技術新興機構 創発的研究支援事業
Authorship：Principal investigator
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インフルエンザウイルスとヒト免疫不全症候群ウイルスの脱殻分子メカニズムの解明
2020.4 - 2023.3
科学研究費補助金 基盤研究(C)
三宅康之
Authorship：Principal investigator
ヒトの感染症を引き起こすインフルエンザ、コロナ、エボラ、デング、ジカといった脂質二重膜に包まれたエンベロープRNAウイルスは、細胞内にエンドサイトーシスと呼ばれる食作用で取り込まれる。その後エンドソーム内部の環境が変化することでエンドソーム膜に融合し、ウイルスゲノムが細胞質内へ放出される。ウイルスの細胞内への侵入の素過程における宿主因子の機能の理解は、RNAウイルスの細胞内侵入のメカニズムだけでなく、将来的に宿主因子を標的とした新たな抗ウイルス薬の開発につながることが期待される。そこで、宿主因子とウイルス殻タンパク質の複合体を生化学的に精製し、その分子構造と相互作用メカニズムを明らかにする。
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The HDAC6/USP7 axis in enveloped RNA virus infection
2020.1 - 2023.3
Yasuyuki Miyake, Takahiro Watanabe, Yohei Yamauchi
Authorship：Principal investigator
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Molecular mechanisms of influenza virus uncoating by ubiquitin signals
Grant number：18J40214 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows
Authorship：Other
Industrial property rights 1
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New treatment against influenza virus
Banerjee I , Helenius A , Matthias P , Miyake Y , Yamauchi Y
Teaching Experience (On-campus) 6
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Virology 3
2022
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Molecular Pathology
2022
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Microorganisms and Human
2021
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Molecular Pathology
2021
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病理病態学
2020
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生体と微生物 ウイルス学総論３
2020
Teaching Experience (Off-campus) 1
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ウイルス学
2022.1 （Nagoya City University）
Level：Undergraduate (specialized) Country：Japan