Updated on 2023/09/21

写真a

 
MIYAKE Yasuyuki
 
Organization
Graduate School of Medicine Designated associate professor
Title
Designated associate professor
Contact information
メールアドレス
External link

Degree 3

  1. Ph.D. ( 2006.3   Osaka University ) 

  2. Master(Integrated Biosciences) ( 2002.3   The University of Tokyo ) 

  3. BSc ( 2000.3   Shinshu University ) 

Research Interests 6

  1. RNA virus

  2. Influenzavirus

  3. vRNPs

  4. ubiquitin

  5. HDAC6

  6. molecular structure

Research Areas 3

  1. Life Science / Molecular biology  / Molecular Biology

  2. Life Science / Virology  / Virology

  3. Life Science / Cell biology

Current Research Project and SDGs 1

  1. ウイルス感染における宿主因子の動態と分子機能の解明

Research History 8

  1. Nagoya University   Department of Virology   Designated associate professor

    2023.4

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    Country:Japan

  2. Nagoya University   Graduate School of Medicine   Assistant Professor

    2020.4 - 2023.3

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    Country:Japan

  3. University of Bristol   School of Cellular and Molecular Medicine   Researcher

    2018.5 - 2020.3

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    Country:United Kingdom

  4. Nagoya University   Graduate School of Medicine   JSPS Research Fellow

    2018.4 - 2020.3

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    Country:Japan

  5. Shinshu University   Researcher

    2016.4 - 2018.3

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    Country:Japan

  6. Friedrich Miescher Institute for Biomedical Research   Epigenetics group   Researcher

    2010.3 - 2015.12

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    Country:Switzerland

  7. Kyoto University   Graduate School of Biostudies   Researcher

    2006.4 - 2010.3

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    Country:Japan

  8. RIKEN   Laboratory of Cellular Physiology   Student Trainee

    2002.4 - 2006.3

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    Country:Japan

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Education 3

  1. Osaka University   Graduate School, Division of Medical Sciences

    - 2006.3

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    Country: Japan

  2. The University of Tokyo

    - 2002.3

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    Country: Japan

  3. Shinshu University   Faculty of Science   Biological Science

    - 2000.3

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    Country: Japan

Professional Memberships 3

  1. 日本分子生物学会

    2000.12

  2. 日本ウイルス学会

    2020.9

  3. 日本細胞生物学会

    2022.3

Awards 2

  1. Pfizer Forschungspreis (Infektiologie, Rheumatologie und Immunologie)

    2016.1   Pfizer  

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    Award type:International academic award (Japan or overseas)  Country:Switzerland

  2. CMM Awayday Best Poster Prize

    2019.1   University of Bristol   Influenza virus uses transportin 1 for vRNP debundling during cell entry

    Miyake Yasuyuki

 

Papers 9

  1. Influenza virus uses transportin 1 for vRNP debundling during cell entry Reviewed International coauthorship

    Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, Kutay U, Helenius A, Yamauchi Y

    Nature Microbiology   Vol. 4 ( 4 ) page: 578 - 586   2019.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41564-018-0332-2

  2. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition Reviewed

    Miyake Y, Keusch JJ, Wang L, Saito M, Hess D, Wang X, Melancon BJ, Helquist P, Gut H, Matthias P

    Nature Chemical Biology   Vol. 12 ( 9 ) page: 748 - 754   2016.9

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nchembio.2140

  3. Influenza A virus uses the aggresome processing machinery for host cell entry Reviewed

    Banerjee I, Miyake Y, Nobs SP, Schneider C, Horvath P, Kopf M, Matthias P, Helenius A, Yamauchi Y

    Science   Vol. 346 ( 6208 ) page: 473 - 477   2014.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1126/science.1257037

  4. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway Reviewed

    Miyake Y, Nakamura M, Nabetani A, Shimamura S, Tamura M, Yonehara S, Saito M, Ishikawa F

    Molecular cell   Vol. 36 ( 2 ) page: 193 - 206   2009.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molcel.2009.08.009

  5. Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways Reviewed

    Longlong Wang, Etori Aguiar Moreira, Georg Kempf, Yasuyuki Miyake, Blandina I. Oliveira Esteves, Amal Fahmi, Jonas V. Schaefer, Birgit Dreier, Yohei Yamauchi, Marco P. Alves, Andreas Plückthun, Patrick Matthias

    Cell Reports   Vol. 39 ( 4 ) page: 110736 - 110736   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.celrep.2022.110736

    Web of Science

    Scopus

    PubMed

  6. A STING inhibitor suppresses EBV‐induced B cell transformation and lymphomagenesis Reviewed

    Shouhei Miyagi, Takahiro Watanabe, Yuya Hara, Masataka Arata, Md. Kamal Uddin, Keisuke Mantoku, Ken Sago, Yusuke Yanagi, Takeshi Suzuki, H. M. Abdullah Al Masud, Jun‐ichi Kawada, Shigeo Nakamura, Yasuyuki Miyake, Yoshitaka Sato, Takayuki Murata, Hiroshi Kimura

    Cancer Science   Vol. 112 ( 12 ) page: 5088 - 5099   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1111/cas.15152

    Web of Science

    Scopus

    PubMed

    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.15152

  7. Acetylation site specificities of lysine deacetylase inhibitors in human cells Reviewed International coauthorship

    Schölz C, Weinert BT, Wagner SA, Beli P, Miyake Y, Qi J, Jensen LJ, Streicher W, McCarthy AR, Westwood NJ, Lain S, Cox J, Matthias P, Mann M, Bradner JE, Choudhary C

    Nature biotechnology   Vol. 33 ( 4 ) page: 415 - 423   2015.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nbt.3130

  8. Aberrant DNA polymerase alpha is excluded from the nucleus by defective import and degradation in the nucleus Reviewed

    Eichinger CS, Mizuno T, Mizuno K, Miyake Y, Yanagi K, Imamoto N, Hanaoka F

    The Journal of Biological Chemistry   Vol. 284 ( 44 ) page: 30604 - 30614   2009.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M109.024760

  9. Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation Reviewed

    Miyake Y, Mizuno T, Yanagi K, Hanaoka F

    The Journal of Biological Chemistry   Vol. 280 ( 13 ) page: 12643 - 12652   2005.4

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M413280200

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Books 3

  1. インフルエンザウイルスの細胞内侵入の生化学

    三宅 康之, 山内 洋平( Role: Joint author)

    日本生化学会  2022.6 

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    Language:English

  2. Molecular function of host factors involved in cellular entry of influenza A virus

    Yasuyuki Miyake( Role: Sole author ,  Topics from special edition)

    the New Science Co., Ltd.  2022.5 

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    Language:Japanese Book type:Textbook, survey, introduction

  3. Purification of Unanchored Polyubiquitin Chains from Influenza Virions

    Miyake Yasuyuki, Matthias Patrick, Yamauchi Yohei( Role: Contributor ,  Chapter 16)

    Humana Press  2018  ( ISBN:978-1-4939-8677-4

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    Responsible for pages:329-342   Language:English Book type:Scholarly book

    DOI: 10.1007/978-1-4939-8678-1_16

MISC 2

  1. 重症ウイルス感染症/ウイルス関連腫瘍を制御するための宿主因子探索と創薬応用

    佐藤好隆, 渡辺崇広, 三宅康之, 木村 宏

    最先端ナノライフシステム研究     page: 24 - 29   2022.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (bulletin of university, research institution)  

  2. ヒストン脱アセチル化酵素HDAC6の結晶構造から明らかにされたチューブリンに対する特異性および選択的な阻害剤との結合 Invited International coauthorship

    三宅康之 , パトリック マティアス

    ライフサイエンス新着論文レビュー     2016.8

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    Authorship:Lead author   Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

    DOI: 10.7875/first.author.2016.083

Presentations 11

  1. ENDOSOMAL DEUBIQUITINASE USP7 PROMOTES INFLUENZA VIRUS UNCOATING International conference

    Alina Rozanova, Takahiro Watanabe, Naoki Narita, Hiroshi Kimura, Yasuyuki Miyake, Yohei Yamauchi

    Negative Strand Virus Meeting 2022  2022.6.13 

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    Event date: 2022.6

    Language:English   Presentation type:Oral presentation (general)  

  2. 宿主タンパク質を介したウイルス脱殻反応の分子機構解明 International conference

    原 優矢, 三宅 康之, 山内 洋平, 木村 宏

    第69回日本ウイルス学会学術集会  2022.11.15 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  3. Elucidating the interactions between Influenza A Matrix Protein M1 and host cell factor Transportin-1 during vRNP debundling International conference

    2022.11.14 

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    Event date: 2022.11

    Language:English   Presentation type:Oral presentation (general)  

  4. Molecular mechanisms of uncoating in human coronavirus 229E International conference

    2022.11.15 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Oral presentation (general)  

  5. USP7 promotes influenza A virus uncoating at late endosomes International conference

    Alina Rozanova, Takahiro Watanabe, Naoki Narita, Yasuyuki Miyake, Yohei Yamauchi

    2022.6.28 

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    Event date: 2022.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  6. HOW INFLUENZA A VIRUS MATRIX PROTEIN M1 INTERACTS WITH HOST CELL FACTOR TRANSPORTIN-1 DURING VRNP DEBUNDLING International conference

    Atzin Ceron, Yasuyuki Miyake, Yohei Yamauchi, Hiroshi Kimura

    Negative Strand Virus Meeting 2022  2022.6.13 

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    Event date: 2022.6

    Language:English   Presentation type:Poster presentation  

  7. MOLECULAR MECHANISMS OF HUMAN CORONAVIRUS ENDOSOMAL UNCOATING International conference

    Miki Umeda, Tatsuki Tanito, Yoshitaka Sato, Mark Marsh, Hiroshi Kimura, Yohei Yamauchi, Yasuyuki Miyake

    Negative Strand Virus Meeting 2022  2022.6.12 

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    Event date: 2022.6

    Language:English   Presentation type:Poster presentation  

  8. INSIGHTS INTO INFLUENZA A VIRUS VRNP DEBUNDLING International conference

    Yuya Hara, Hiroshi Kimura, Yasuyuki Miyake, Yohei Yamauchi

    Negative Strand Virus Meeting 2022  2022.6.13 

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    Event date: 2022.6

    Language:English   Presentation type:Poster presentation  

  9. Molecular mechanism(s) for cellular entry of RNA viruses Invited

    Yasuyuki Miyake

    Premium Lecture  2021.11.18 

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    Event date: 2021.11

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  10. Molecular function of USP7 protein in cellular entry of influenza virus International coauthorship

    Alina Rozanova, Yasuyuki Miyake, and Yohei Yamauchi

    43th BMSJ 2020  2020.12.3 

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    Event date: 2020.12

    Language:English   Presentation type:Poster presentation  

    Venue:online   Country:Japan  

  11. 宿主因子を標的とした新規抗ウイルス薬の探索に向けて Invited International conference

    三宅康之

    中部地区医療・バイオ系シーズ発表会  2021.12.7 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. ウイルス感染における宿主因子の動態と分子機能の解明

    2021.4 - 2024.3

    科学技術振興機構  創発的研究支援事業 

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    Grant type:Competitive

  2. The HDAC6/USP7 axis in enveloped RNA virus infection

    2019.12 - 2023.3

    Yasuyuki Miyake

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. ウイルス感染における宿主因子の動態と分子機能の解明

    2021.4 - 2024.3

    科学技術新興機構  創発的研究支援事業 

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    Authorship:Principal investigator 

  2. RNAウイルス脱殻メカニズムの分子機構解明

    2023.4 - 2026.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Competitive

  3. インフルエンザウイルスとヒト免疫不全症候群ウイルスの脱殻分子メカニズムの解明

    2020.4 - 2023.3

    科学研究費補助金  基盤研究(C)

    三宅康之

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    Authorship:Principal investigator 

     ヒトの感染症を引き起こすインフルエンザ、コロナ、エボラ、デング、ジカといった脂質二重膜に包まれたエンベロープRNAウイルスは、細胞内にエンドサイトーシスと呼ばれる食作用で取り込まれる。その後エンドソーム内部の環境が変化することでエンドソーム膜に融合し、ウイルスゲノムが細胞質内へ放出される。ウイルスの細胞内への侵入の素過程における宿主因子の機能の理解は、RNAウイルスの細胞内侵入のメカニズムだけでなく、将来的に宿主因子を標的とした新たな抗ウイルス薬の開発につながることが期待される。そこで、宿主因子とウイルス殻タンパク質の複合体を生化学的に精製し、その分子構造と相互作用メカニズムを明らかにする。

  4. The HDAC6/USP7 axis in enveloped RNA virus infection

    2020.1 - 2023.3

    Yasuyuki Miyake, Takahiro Watanabe, Yohei Yamauchi

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    Authorship:Principal investigator 

  5. Molecular mechanisms of influenza virus uncoating by ubiquitin signals

    Grant number:18J40214  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

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    Authorship:Other 

Industrial property rights 1

  1. New treatment against influenza virus

    Banerjee I , Helenius A , Matthias P , Miyake Y , Yamauchi Y

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    Application no:WO2015189816 A1  Date applied:2015

 

Teaching Experience (On-campus) 12

  1. 生体と微生物 ウイルス学総論3

    2023

  2. 病理病態学

    2023

  3. 生体と微生物 ウイルス学実習

    2023

  4. Molecular Pathology

    2022

  5. Virology 3

    2022

  6. 生体と微生物 ウイルス学実習

    2022

  7. Microorganisms and Human

    2021

  8. Molecular Pathology

    2021

  9. 生体と微生物 ウイルス学実習

    2021

  10. 病理病態学

    2020

  11. 生体と微生物 ウイルス学総論3

    2020

  12. 生体と微生物 ウイルス学実習

    2020

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Teaching Experience (Off-campus) 2

  1. ウイルス学

    2023.1 Nagoya City University)

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    Level:Undergraduate (specialized)  Country:Japan

  2. ウイルス学

    2022.1 Nagoya City University)

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    Level:Undergraduate (specialized)  Country:Japan