Award type：Award from Japanese society, conference, symposium, etc. 

Award type：Award from Japanese society, conference, symposium, etc. 

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/chem.202401402

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Organic Chemistry  

Unsymmetrical H-phosphonates were synthesized by a rapid (<15 s) and mild (20 °C) process in a microflow reactor as the first example of the sequential direct substitution of the chlorine atoms in PCl3 with alkoxyl/aryloxy groups using equivalent amounts of PCl3 and alcohols. The optimal base concentration differed in each step, presumably attributed to differences in the Brønsted basicity of the electrophilic intermediates. Phosphite hydrolysis was observed, and the structure-hydrolysis relationship was quantitatively evaluated.

DOI： 10.1039/D4OB00358F

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Organic Chemistry  

Unsymmetrical H-phosphonates were synthesized by a rapid (<15 s) and mild (20 °C) process in a microflow reactor as the first example of the sequential direct substitution of the chlorine atoms in PCl3 with alkoxyl/aryloxy groups using equivalent amounts of PCl3 and alcohols. The optimal base concentration differed in each step, presumably attributed to differences in the Brønsted basicity of the electrophilic intermediates. Phosphite hydrolysis was observed, and the structure-hydrolysis relationship was quantitatively evaluated.

DOI： 10.1021/acs.oprd.4c00009

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Chemistry - An Asian Journal  

Substituted indoles are important as drugs. A number of valuable indoles have been synthesized via nucleophilic substitution at the 3’-position of indoles. However, the preparation of an indolylmethyl electrophile containing a tertiary carbon at the 3’-position and its subsequent nucleophilic substitution are challenging owing to the instability of the electrophile. Herein, we demonstrated the rapid one-flow synthesis of indoles via sequential 1,2-addition/nucleophilic substitution of indolyl-3-carbaldehydes. The use of a microflow technology helped in suppressing the undesired reactions caused by the unstable intermediates, resulting in significantly higher yields and reproducibility compared to those under batch conditions. A crown ether was effective when 1-alkylindole-3-carboxaldehyde was used as a substrate. However, the crown ether exerted a detrimental effect when 1H-indole-3-carboxaldehyde was used. A total of 15 structurally diverse indole derivatives were obtained in generally acceptable to good yields.

DOI： 10.1002/asia.202400256

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Chemical Communications  

A rapid nucleophilic substitution reaction was developed using carbocations generated from diarylmethanol and trifluoromethanesulfonic acid. Undesired reactions caused by the carbocations were suppressed, presumably due to the rapid and uniform generation of carbocations and the subsequent rapid and uniform distribution of nucleophiles by the micro-flow technology.

DOI： 10.1039/d3cc06308a

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Organic Chemistry  

Unsymmetrical H-phosphonates were synthesized by a rapid (<15 s) and mild (20 °C) process in a microflow reactor as the first example of the sequential direct substitution of the chlorine atoms in PCl3 with alkoxyl/aryloxy groups using equivalent amounts of PCl3 and alcohols. The optimal base concentration differed in each step, presumably attributed to differences in the Brønsted basicity of the electrophilic intermediates. Phosphite hydrolysis was observed, and the structure-hydrolysis relationship was quantitatively evaluated.

DOI： 10.1021/acs.joc.3c02467

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PubMed

Language：English   Publishing type：Research paper (scientific journal)   Publisher：Reaction Chemistry and Engineering  

Amide bond formation is one of the most prevalent reactions in the pharmaceutical industry, among which the Schotten-Baumann reaction with a long history is useful as a potential green amide formation approach. However, the use of water in the reaction system often causes undesired hydrolysis and can generate a multiphase system. This makes the reaction space complex, making it challenging to find the optimal conditions. In this study, the Schotten-Baumann reaction was studied in a continuous flow and was optimised with two objectives using a Bayesian optimisation algorithm based on the q-noisy expected hypervolume improvement (qNEHVI) acquisition function. The algorithm guided the experiment design over a range of electrophiles, equivalents, solvents, and flow rates, and was able to identify the Pareto front of optimal solutions efficiently. Based on the optimisation results, reactions under a flow and batch conditions were compared; undesired hydrolysis was suppressed successfully using the flow conditions. Finally, the relationship between the solvent and flow rate was discussed to gain more insights into this reaction.

DOI： 10.1039/d3re00502j

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Chemistry - An Asian Journal  

Substituted indoles are important as drugs. A number of valuable indoles have been synthesized via nucleophilic substitution at the 3’-position of indoles. However, the preparation of an indolylmethyl electrophile containing a tertiary carbon at the 3’-position and its subsequent nucleophilic substitution are challenging owing to the instability of the electrophile. Herein, we demonstrated the rapid one-flow synthesis of indoles via sequential 1,2-addition/nucleophilic substitution of indolyl-3-carbaldehydes. The use of a microflow technology helped in suppressing the undesired reactions caused by the unstable intermediates, resulting in significantly higher yields and reproducibility compared to those under batch conditions. A crown ether was effective when 1-alkylindole-3-carboxaldehyde was used as a substrate. However, the crown ether exerted a detrimental effect when 1H-indole-3-carboxaldehyde was used. A total of 15 structurally diverse indole derivatives were obtained in generally acceptable to good yields.

DOI： 10.1002/asia.202300909

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Publisher：European Journal of Organic Chemistry  

Smaller cyclic peptides containing non-proteinogenic amino acids have garnered much attention for use as drugs, but their chemical synthesis is extremely challenging. In this study, a rapid (60.5 min) synthesis of 7- and 14-membered cyclic peptides containing N-methyl- and β-amino acids was achieved by only switching the concentrations (0.20 M or 0.01 M) of the substrates. The developed approach required neither expensive transition-metals nor expensive coupling agents. As far as we could ascertain, this is the first report of the synthesis of smaller (≤16-membered) cyclic N-methylated peptides via dimerization-cyclization strategy.

DOI： 10.1002/ejoc.202300700

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Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1039/d3sc01333b

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Organic Letters  

We developed one-flow syntheses of unsymmetrical sulfamides and N-substituted sulfamate esters by changing a nucleophile and a tertiary amine from inexpensive and commercially available chlorosulfonic acid. In the synthesis of N-substituted sulfamate esters, unexpected symmetrical sulfite formation was suppressed by changing the tertiary amine. The effect of tertiary amines was proposed using linear regression. Our approach rapidly (≤90 s) provides desired products containing acidic and/or basic labile groups without tedious purification under mild (20 °C) conditions.

DOI： 10.1021/acs.orglett.3c01546

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Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/cplu.202300176

PubMed

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Angewandte Chemie - International Edition  

Although cyclic peptides have become increasingly important as drugs, the most conventional peptide cyclization method using moderately active coupling agents suffers from a lot of waste and high cost as well as long reaction times and burdensome purification. Herein, we report an unconventional approach to peptide cyclization that uses acylammonium species generated from inexpensive and less wasteful Me2NBn and ClCO2i-Pr. Using this approach, we observed the desired rapid activation of the C-terminus of cyclization precursors by an acylammonium ion for rapid and epimerization/dimerization-free cyclization of synthetically challenging peptides, including a difficult cyclization involving N-methyl amide bond formation. The ease of purification, productivities, and reaction mass efficiencies of our approach were significantly superior to those in previous reports. We synthesized a previously reported versicotide D analogue, and our data indicated that its assigned stereostructure should be revised.

DOI： 10.1002/anie.202300647

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Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1038/s42004-023-00837-1

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1039/D2RE00453D

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.5059/yukigoseikyokaishi.80.986

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/chem.202200932

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Authorship：Last author,　Corresponding author   Language：Japanese   Publisher：Organic Process Research and Development  

Peptides have become increasingly important as drugs and drug candidates. In particular, specialty peptides have garnered considerable attention in recent years because of their improved metabolic stability, higher affinity, and biological target selectivity; some of them have the ability to enable cell membrane permeation and oral administration. Despite its long history, peptide synthesis has various limitations, such as high cost, generation of large amounts of waste, and the requirement for hazardous reagents and solvents. Microflow synthesis, wherein the inner diameter of the reaction tube is ≤1 mm, presents several advantages compared with conventional batch synthesis, such as precise control of the reaction time on a short scale, precise reaction temperature control, and facile scale-up with high reproducibility. Microflow technology has been utilized for peptide synthesis since the beginning of the 21st century. The advantages of microflow synthesis enable the use of highly active and unstable chemical species or high-Temperature conditions that accelerate peptide synthesis. The combined use of microflow technology, automated synthesis, and online monitoring technologies has emerged in recent years. This approach not only improved the synthetic efficiency but also afforded large amounts of reliable data that can be used to train machine learning models. This review summarizes the solid-and solution-phase syntheses of α-peptides and specialty peptides, including N-methylated peptides, β-peptides, and cyclic peptides, reported mainly after 2017. The recently reported mesoflow peptide syntheses (inner diameter of the reaction channels > 1 mm), the microflow automated syntheses, and in-line analysis are covered in this review.

DOI： 10.1021/acs.oprd.2c00074

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Authorship：Last author,　Corresponding author   Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.1039/d2ob00167e

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Language：English   Publisher：Methods in Molecular Biology  

A detailed protocol is described for the continuous-flow synthesis of N-methylated peptides. N-Methylated peptides are very important class of bioactive compounds compared with normal peptides because they can enhance oral bioavailability, cell membrane permeability, and stability against enzymatic degradation. In our developed flow synthesis, a variety of N-methylated dipeptides is obtained in high yields without severe racemization from equivalent amounts of amino acids. The addition of a strong Brønsted acid is critical to generate the highly reactive N-methylimidazolium cation species to accelerate the amidation. The developed approach enabled the synthesis of a bulky peptide with a higher yield in a shorter amount of time compared with the results of conventional amidation.

DOI： 10.1007/978-1-0716-2489-0_4

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Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/cmtd.202100053

Language：Japanese   Publisher：The Society of Synthetic Organic Chemistry, Japan  

DOI： 10.5059/yukigoseikyokaishi.79.346

CiNii Research

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/chem.202100059

Language：Japanese   Publishing type：Research paper (scientific journal)  

DOI： 10.1055/s-0040-1706605

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Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

Language：Japanese   Publisher：The Pharmaceutical Society of Japan  

<p>Peptide drugs become increasingly important. In particular, specialty peptides including cyclic peptides and <i>N</i>-methylated peptides have garnered much attention in recent years. However, low cost production of these peptides has not been achieved. Nearly 140 years have passed since the first report of peptide bond formation by Theodor Curtius and numerous synthetic approaches have been developed for peptide syntheses. It seems like a very challenging task for making innovation in peptide syntheses. Micro-flow synthesis that uses thin channels as reaction space emerged in 1990’s. It provides new values for the uncontrollable reactions when using traditional batch reactors. Here, I introduce our amide bond formation using micro-flow technologies for accelerating innovation in peptide syntheses.</p>

DOI： 10.14894/medchem.30.4_193

CiNii Research

Language：Japanese   Publisher：Organic Process Research and Development  

The use of microfluidics has been regarded as a promising solution for the costly and complex preparation of liposomes, and the development of controllable and scalable liposome production using simple-structured, readily available, and inexpensive "off-the-shelf"microfluidics remains important pursuit. We have achieved simple and inexpensive production of liposomes using an off-the-shelf V-shaped mixer. The size of liposomes was controlled (50-70 nm diameter, PDI < 0.1) in the desired range (<100 nm) by changing the relative flow rate of the ethanol solution of lipids and the aqueous solution. The developed approach is scalable (12 mL/min), and several representative lipids, including inexpensive Span 60, can be used for the preparation of nanoparticles.

DOI： 10.1021/acs.oprd.0c00174

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Language：English   Publishing type：Research paper (scientific journal)  

Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.bmc.2020.115558

Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1021/acs.orglett.0c00910

PubMed

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1002/anie.202002106

PubMed

Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

DOI： 10.1039/d0cc01403f

PubMed

Language：Japanese   Publisher：Chemistry - An Asian Journal  

β-Amino acid N-carboxy anhydrides (β-NCAs) are rarely used in the synthesis of β-peptides, which is due mainly to the poor availability of these potentially useful substrates. Herein, we describe the heretofore challenging synthesis of β-NCAs via a single-step, rapid, and mild formation using pH flash switching and flash dilution, which are aspects of micro-flow technology. We synthesized 15 β-NCAs in good to excellent yields that included acid-labile β-NCAs that cannot be readily synthesized using the conventional Leuchs approach. Scaled-up synthesis using this process can be readily achieved via continuous operation.

DOI： 10.1002/asia.201901429

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Language：English  

DOI： 10.1016/j.bmc.2019.115207

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CiNii Research

Language：English   Publisher：Royal Society of Chemistry ({RSC})  

DOI： 10.1039/c9ob02066g

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

Language：English   Publisher：Wiley  

DOI： 10.1002/chem.201903531

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

Publisher：Wiley  

DOI： 10.1002/chem.201904370

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

Language：English  

DOI： 10.1039/c9ra00229d

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Language：English   Publisher：Wiley  

DOI： 10.1002/asia.201801488

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

Language：English   Publishing type：Research paper (scientific journal)  

© 2018 Elsevier Ltd Dithienopyrrole-based organic dyes that combine an electron-donating moiety (D), a π-conjugated bridge moiety (π), and an electron-accepting moiety (A) were designed and synthesized in short steps by previously developed one-pot Suzuki-Miyaura coupling approach. Absorption wavelengths of the dyes were readily tuned by altering the D and A moieties. The use of a strongly electron-withdrawing cyanopyridone acceptor enabled NIR absorption. A synthesized sensitizer, 2j, exerted potent phototoxicity mainly via a Type I mechanism in cells. A nitrogen atom in the dithienopyrrole ring serves as a connecting point for the introduction of functional building blocks that can improve the properties of sensitizers, which makes this D-π-A sensitizer a valuable template for the further development of sensitizers.

DOI： 10.1016/j.bmcl.2018.07.025

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Other Link： http://orcid.org/0000-0002-6836-4180

Language：English   Publisher：Wiley  

DOI： 10.1002/anie.201803549

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Other Link： http://orcid.org/0000-0002-6836-4180

Language：English   Publisher：Elsevier Ltd  

Micro-flow photochemical reactions have great advantage over batch photochemical reactions due to its high light-penetration efficiency. Integrated micro-flow reaction enables efficient synthesis of structurally complex compounds from simple starting materials and it can avoid handling of explosive, toxic, unstable, or odorous intermediates. Combination of micro-flow photochemical reactions with integrated micro-flow synthesis enhances their benefits. Here we summarize recently reported integrated multi-step micro-flow synthesis containing various photochemical reactions.

DOI： 10.1016/j.tetlet.2018.03.019

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Other Link： http://orcid.org/0000-0002-6836-4180

Publishing type：Research paper (scientific journal)  

© Georg Thieme Verlag Stuttgart New York. Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot S N Ar reaction/intramolecular C-H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.

DOI： 10.1055/s-0036-1591885

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Other Link： http://orcid.org/0000-0002-6836-4180

Language：English   Publishing type：Research paper (scientific journal)   Publisher：PERGAMON-ELSEVIER SCIENCE LTD  

Isoxazole is an important pharmacophore that is critical for biological activity. The isoxazole ring ranks 33rd in frequency among the 351 ring systems found in marketed drugs, thus suggesting a great deal of interest in the synthesis of functional isoxazoles. In recent years, various approaches have been developed for the synthesis and functionalization of isoxazoles. This comprehensive survey summarizes the recent new synthetic approaches to functionalized isoxazoles, with particular focus on the last three years with regard to the following reaction types: (1) 1,3-dipolar cycloaddition, (2) condensation, (3) cycloisomerization, and (4) direct functionalization. (C) 2018 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2018.02.020

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley-VCH Verlag  

The development of new anchoring groups is important to facilitate effective co-sensitization in dye-sensitized solar cells (DSSCs). Herein, stable organic D–π–A dyes that contain new heterocyclic hydantoin-based anchoring groups have been designed, synthesized, and used in DSSCs. These dye sensitizers were evaluated in terms of their absorption spectra, electrochemical properties, and performance in DSSC devices. Although only one-third of the amount of hydantoin-containing dyes adsorbed onto TiO2 relative to their cyanoacrylic-acid-containing analogues, they exhibited effective photoexcited electron-transfer properties. External quantum efficiencies of over 80 % was observed, which were comparable to those of the cyanoacrylic-acid-containing dyes. In addition, the new hydantoin-containing dyes exhibited significant robustness, which could allow improved stability of their corresponding photovoltaic devices under harsh conditions, such as high temperature and humidity.

DOI： 10.1002/ajoc.201700542

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Other Link： http://orcid.org/0000-0002-6836-4180

Language：English   Publishing type：Research paper (scientific journal)   Publisher：AMER CHEMICAL SOC  

Intramolecular electrophilic aromatic substitution (SEAr) reaction at the 5-position of isoxazoles was achieved. The electron-donating heteroatoms (N and O) at the 4-position of isoxazoles, which can be readily prepared based on our originally developed synthetic procedure, and a cationic gold(I) catalyst are essential for the intramolecular SEAr reaction to synthesize isoxazole-containing fused heterocycles. Structurally diverse isoxazolopyridines 6 and isoxazolopyrans 9, including base-labile 3-unsubstituted derivatives, were synthesized in good to high yields. The addition of N-phenylbenzaldimine as a hydrogen acceptor improved yields in the synthesis of isoxazolopyridines. Furthermore, synthesis of the tetracyclic fused ring system 12 was achieved by tandem cyclization from the corresponding diyne 11.

DOI： 10.1021/acs.orglett.7b03760

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Language：English   Publisher：WILEY-V C H VERLAG GMBH  

The Wolff rearrangement of -diazo carbonyl compounds has remained important in organic synthesis since its development more than 115 years ago. The risks involved in handling diazo compounds can be minimized by utilizing micro-flow technology. In addition, photochemical Wolff rearrangement can be carried out efficiently with the aid of micro-flow technology. Integrated micro-flow synthesis is therefore well-suited to the preparation of -diazo carbonyl compounds and their photochemical Wolff rearrangement. This review article summarizes recently reported micro-flow photochemical Wolff rearrangements and their application in integrated micro-flow syntheses.

DOI： 10.1002/ejoc.201700789

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCIENCE BV  

Background: Subcellular localization of a photosensitizer is known to determine the therapeutic efficacy of photodynamic therapy (PDT). Cell membrane is an optimal target that promises an effective treatment outcome. Objectives: We previously developed a novel photosensitizer named porphyrus envelope (PE) by combining hemagglutinating virus of Japan envelope (HVJ-E) with lipidated protoporphyrin IX (PpIX lipid). In the current study, the cellular localization of PE and its ability to induce multiple anti-tumor effect were characterized.
Materials and Methods: The localization and uptake of PpIX lipid in cells were evaluated with confocal laser scanning microscopy and a cell-based fluorescent assay, respectively. The ability of PE to suppress the migration and proliferation of cancer cells was assessed using a scratch-wound assay. The synergistic effect of PDT and HVJ-E treatment was evaluated using an in vitro experiment with PC-3 cells.
Results: PE localized along the cell membrane and PpIX lipid accumulated selectively in the prostate cancer cells within 10 min. Also, PE maintained the ability to undergo fusion and induce cancer cell death even after light irradiation at the dose for PDT. Incubation with PE resulted in delayed migratory and proliferative activity of PC 3 cells. PE-mediated PDT was twice as effective when cells were further incubated with PE following PDT.
Conclusions: PE allows rapid drug delivery targeting the cell membrane. Because the cytotoxicity of HVJ-E was maintained, synergistic effect of HVJ-E and the photochemical reactions resulted in highly effective killing of prostate cancer cells in vitro and thus represents a promising treatment for prostate cancer.

DOI： 10.1016/j.pdpdt.2017.10.017

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Language：Japanese   Publisher：SOC SYNTHETIC ORGANIC CHEM JPN  

Thiophene-based organic D-pi-A dyes exert various functions as sensitizers of dye-sensitized solar cells, p-type semiconductors of thin-film organic solar cells, and inhibitors of aggregation of amyloid-beta and tau proteins those are regarded as promising drug targets of Alzheimer's disease. This account describes rapid and systematic synthesis of thiophene-based organic D-pi-A dyes via our developed, one-pot, cross-coupling approach and evaluation of their various functions in order to acquire high-quality structure-function relationship information.

DOI： 10.5059/yukigoseikyokaishi.75.941

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：WILEY-V C H VERLAG GMBH  

In this study, synthetically readily accessible, thiophene-based organic D--A sensitizers exerted high phototoxicity and are valuable as sensitizer templates for use in photodynamic therapy (PDT). Evaluation of the antitumor activity of our previously synthesized D--A sensitizers under photoirradiation revealed their potent phototoxicity. The structural requirements of the D--A sensitizer for phototoxicity were elucidated with the rapid synthesis of structurally simplified analogues and evaluation of their antitumor activity under photoirradiation. Our developed sensitizers mainly accumulated in mitochondria and damaged cancer cells through both Type I and Type II mechanisms. The developed new template could be useful in the future development of sensitizers that could fulfil the requirements for PDT.

DOI： 10.1002/ejoc.201701019

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Language：English   Publisher：GEORG THIEME VERLAG KG  

Functionalized isoxazoles are important as pharmaceuticals and agrochemicals. Generally, electrophilic aromatic substitution or generation of carbanions/electrophilic trapping approach is used to introduce functional groups into unsubstituted heteroaromatics. However, these approaches have not been simple to apply to unsubstituted isoxazoles due to their poor nucleophilicity and instability under basic conditions. Recently several approaches have been reported to overcome these problems. This review summarizes the functionalization of isoxazoles, including SEAr reactions and C-H direct arylations, towards the step-by-step multifunctionalization of isoxazoles.

DOI： 10.1055/s-0036-1588784

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Society of Synthetic Organic Chemistry  

Mannopeptimycin is an attractive drug candidate due to its strong antimicrobial activity against drug-resistant strains. However, detailed elucidation of structure - activity relationship and its mode of action has been hampered because the chemical synthesis of the densely functionalized aglycone moiety consisting of cyclic hexapeptide was not established. The key point in the synthesis of the aglycone was the construction of densely functionalized unnatural amino acids, Aiha-A and Aiha-B. This account describes isolation, structural determination of mannopepti-mycins, previously reported synthesis of Aiha-A and Aiha-B as well as our short-step, high-yielding synthesis of Aihas leading to the first synthesis of mannopeptimycin aglycone with stereochemistry revision of originally proposed structure.

DOI： 10.5059/yukigoseikyokaishi.75.1274

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：BEILSTEIN-INSTITUT  

A solution-phase automated synthesis of the versatile synthetic intermediate, Garner's aldehyde, was demonstrated. tert-Butoxycarbonyl (Boc) protection, acetal formation, and reduction of the ester to the corresponding aldehyde were performed utilizing our originally developed automated synthesizer, ChemKonzert. The developed procedure was also useful for the synthesis of Garner's aldehyde analogues possessing fluorenylmethyloxycarbonyl (Fmoc) or benzyloxycarbonyl (Cbz) protection.

DOI： 10.3762/bjoc.13.13

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DOI： 10.1007/978-1-0716-2489-0_4

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DOI： 10.1007/978-981-16-2458-2_9

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DOI： 10.1016/j.tetlet.2018.03.019

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1016/j.tetlet.2018.02.020

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1055/s-0036-1591885

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1016/j.bmcl.2018.07.025

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/ejoc.201700789

Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1016/j.pdpdt.2017.10.017

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.3762/bjoc.13.13

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1055/s-0036-1588784

Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1039/c6ob02391f

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1016/j.bmcl.2016.11.009

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/anie.201608039

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/chem.201504277

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/ejoc.201501190

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/ejoc.201600392

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/chem.201601031

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/chem.201603980

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/chem.201602817

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1038/ncomms13491

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/chem.201602044

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/asia.201500362

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1071/CH15342

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/chem.201500703

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/chem.201502399

Research data storage URL： http://orcid.org/0000-0002-6836-4180

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/ejoc.201500273

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1016/j.tet.2015.05.102

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/chem.201500979

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/ejoc.201500562

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1021/ja505105t

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1016/j.ejmech.2014.07.095

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/anie.201307987

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1002/chem.201402093

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1021/co500071x

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1055/s-0034-1378244

Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1016/j.tet.2014.09.039

Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1016/j.tetlet.2012.04.059

Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1016/j.bmcl.2010.01.057

PubMed

DOI： 10.1016/j.bmcl.2010.01.035

PubMed

DOI： 10.1021/cb100048q

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PubMed

DOI： 10.1246/bcsj.20090341

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

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Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1248/cpb.58.87

Research data storage URL： http://orcid.org/0000-0002-6836-4180

DOI： 10.1021/op9002455

DOI： 10.1016/j.tetlet.2009.02.149

DOI： 10.1021/bi901018q

PubMed

DOI： 10.1021/cb800078a

DOI： 10.1002/asia.200600156

DOI： 10.1016/j.tetlet.2003.12.138

Event date： 2024.9

Language：Japanese   Presentation type：Poster presentation  

Venue：横浜国立大学常盤台キャンパス   Country：Japan  

Event date： 2024.6 - 2024.7

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Hong Kong Ocean Park Marriott Hotel, Hong Kong, China  

Event date： 2024.6

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：北海道大学鈴木章ホール   Country：Japan  

Event date： 2024.5

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：web講演   Country：Japan  

Event date： 2024.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：日本大学船橋キャンパス　千葉   Country：Japan  

Event date： 2024.3

Language：English   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2024.3

Language：English   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2024.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：日本大学船橋キャンパス　千葉   Country：Japan  

Event date： 2024.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：日本大学船橋キャンパス　千葉   Country：Japan  

Event date： 2024.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：日本大学船橋キャンパス　千葉   Country：Japan  

Event date： 2024.2

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：イイノホール、東京   Country：Japan  

Event date： 2024.1

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：岡崎コンファレンスセンター、愛知   Country：Japan  

Event date： 2023.12

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：京都大学桂キャンパス、京都   Country：Japan  

Event date： 2023.11

Language：Japanese   Presentation type：Poster presentation  

Venue：中央大学、東京   Country：Japan  

Event date： 2023.11

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：ホテルマイステイズ新大阪コンファレンスセンター、大阪   Country：Japan  

Event date： 2023.11

Language：Japanese   Presentation type：Poster presentation  

Venue：名古屋大学　愛知   Country：Japan  

Event date： 2023.11

Language：Japanese   Presentation type：Poster presentation  

Venue：名古屋大学　愛知   Country：Japan  

Event date： 2023.11

Language：Japanese   Presentation type：Poster presentation  

Venue：名古屋大学　愛知   Country：Japan  

Event date： 2023.11

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：早稲田大学国際会議場、東京   Country：Japan  

Event date： 2023.11

Language：Japanese   Presentation type：Poster presentation  

Venue：早稲田大学国際会議場、東京   Country：Japan  

Event date： 2023.10

Language：Japanese   Presentation type：Poster presentation  

Venue：タワーホール船堀、千葉   Country：Japan  

Event date： 2023.10

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Hotel Nikko Narita, Ibaraki, Japan   Country：Japan  

Event date： 2023.8

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：富山県立大学、富山   Country：Japan  

Event date： 2023.7

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：名古屋大学　愛知   Country：Japan  

Event date： 2023.7

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：名古屋大学、愛知   Country：Japan  

Event date： 2023.6

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：つくば国際会議場、茨城   Country：Japan  

Event date： 2023.4

Language：English   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：Imperial College London, Molecular Sciences Research Hub, London, UK   Country：United Kingdom  

Event date： 2023.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：北海道大学　北海道   Country：Japan  

Event date： 2023.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京理科大学野田キャンパス　千葉   Country：Japan  

Event date： 2023.3

Language：English   Presentation type：Oral presentation (general)  

Country：Japan  

Event date： 2023.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京理科大学野田キャンパス　千葉   Country：Japan  

Event date： 2023.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京理科大学野田キャンパス　千葉   Country：Japan  

Event date： 2022.12

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Innovis Building, Singapore   Country：Singapore  

Event date： 2022.11

Language：English   Presentation type：Oral presentation (general)  

Event date： 2022.11

Language：English   Presentation type：Oral presentation (general)  

Event date： 2022.11

Language：English   Presentation type：Oral presentation (general)  

Event date： 2022.11

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2022.11

Language：Japanese   Presentation type：Poster presentation  

Venue：早稲田大学国際会議場、東京   Country：Japan  

Event date： 2022.11

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：早稲田大学国際会議場、東京   Country：Japan  

Event date： 2022.11

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Nobel Turing Challenge Initiative (NTCI)   Country：Japan  

Event date： 2022.10

Language：English   Presentation type：Oral presentation (general)  

Venue：TAHKNET Hall Sendai, Miyagi, Japan   Country：Japan  

Event date： 2022.10

Language：English   Presentation type：Poster presentation  

Venue：TAHKNET Hall Sendai, Miyagi, Japan   Country：Japan  

Event date： 2022.10

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.10

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.10

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.10

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Hotel Nikko Narita, Ibaraki, Japan   Country：Japan  

Event date： 2022.9

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：アクティブリゾーツ福岡八幡、福岡   Country：Japan  

Event date： 2022.8

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：一橋講堂　東京   Country：Japan  

Event date： 2022.6 - 2022.7

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.6 - 2022.7

Language：Japanese   Presentation type：Poster presentation  

Venue：富山県民会館、富山   Country：Japan  

Event date： 2022.6 - 2022.7

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.6 - 2022.7

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.6 - 2022.7

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.6 - 2022.7

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.6 - 2022.7

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.6 - 2022.7

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2022.6

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：web開催   Country：Japan  

Event date： 2022.6

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：大阪科学技術センター, 大阪   Country：Japan  

Event date： 2022.3

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2022.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：Web講演   Country：Japan  

Event date： 2022.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：Web講演   Country：Japan  

Event date： 2022.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：Web講演   Country：Japan  

Event date： 2022.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：Web講演   Country：Japan  

Event date： 2022.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：Web講演   Country：Japan  

Event date： 2021.12

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Web presentation  

Event date： 2021.12

Language：English   Presentation type：Poster presentation  

Venue：Web presentation  

Event date： 2021.12

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：岡山国際交流センター、岡山   Country：Japan  

Event date： 2021.10

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2021.10

Language：Japanese   Presentation type：Poster presentation  

Venue：web開催   Country：Japan  

Event date： 2021.10

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：web開催   Country：Japan  

Event date： 2021.8

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2021.6

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：web講演   Country：Japan  

Event date： 2021.6

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：Web講演   Country：Japan  

Event date： 2021.5

Language：English   Presentation type：Poster presentation  

Country：China  

Event date： 2021.3

Language：Japanese   Presentation type：Poster presentation  

Venue：Web講演   Country：Japan  

Event date： 2021.3

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：web講演   Country：Japan  

Event date： 2021.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：Web講演   Country：Japan  

Event date： 2021.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：Web講演   Country：Japan  

Event date： 2021.3

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：web講演   Country：Japan  

Event date： 2021.3

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：Web講演   Country：Japan  

Event date： 2021.2

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2020.12

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2020.12

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2020.12

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2020.11

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2020.10

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2020.10

Language：English   Presentation type：Oral presentation (invited, special)  

Country：Japan  

Event date： 2020.10

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2020.8

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2020.7

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：Web講演   Country：Japan  

Event date： 2020.1

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：大阪大学, 大阪   Country：Japan  

Event date： 2020.1

Language：Japanese   Presentation type：Poster presentation  

Venue：大阪大学, 大阪   Country：Japan  

Event date： 2019.12

Language：English   Presentation type：Oral presentation (invited, special)  

Country：Japan  

Event date： 2019.12

Language：English   Presentation type：Oral presentation (general)  

Venue：Taipei International Convention Center, Taipei, Taiwan   Country：Taiwan, Province of China  

Event date： 2019.11

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：名古屋大学, 愛知   Country：Japan  

Event date： 2019.11

Language：Japanese   Presentation type：Oral presentation (general)  

Venue：東京工業大学, 神奈川   Country：Japan  

Event date： 2019.11

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Hotel Nikko Narita, Ibaraki, Japan   Country：Japan  

Event date： 2019.11

Language：English   Presentation type：Poster presentation  

Venue：Skypark Hotel in Kurumayama Kogen, Nagano   Country：Japan  

Event date： 2019.9

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：東北大学青葉台キャンパス　宮城   Country：Japan  

Event date： 2019.7

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Chiba University, Chiba Iodine Resource Innovation Center (CIRIC) Chiba Japan   Country：Japan  

Event date： 2019.4

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：ソラシティコンフェレンスセンター　東京   Country：Japan  

Event date： 2019.4

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：The University of Tokyo Tokyo Japan   Country：Japan  

Event date： 2019.2

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Wellcome Genome Centre UK   Country：United Kingdom  

Event date： 2019.1

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：新霞が関ビル　全社協・灘尾ホール　東京   Country：Japan  

Event date： 2018.12

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：National University of Singapore Singapore   Country：Singapore  

Event date： 2018.11

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：分子科学研究所　岡崎カンファレンスセンター　愛知   Country：Japan  

Event date： 2018.9

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：大阪大学　南部陽一郎ホール　大阪   Country：Japan  

Event date： 2018.7

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：タワーホール船堀　東京   Country：Japan  

Event date： 2018.6

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：日本薬学会長井記念館長井記念ホール　東京   Country：Japan  

Event date： 2018.6

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：東ソー株式会社東京研究所　神奈川   Country：Japan  

Event date： 2018.3

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：ANA クラウンプラザホテル金沢　石川   Country：Japan  

Event date： 2018.1

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Hotel Hankyu EXPO park Osaka Japan   Country：Japan  

Event date： 2017.12

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：岡山大学　岡山   Country：Japan  

Event date： 2017.11

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Embassador International Hotel China   Country：China  

Event date： 2017.11

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：大塚製薬　ヴェガホール　徳島   Country：Japan  

Event date： 2017.10

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：桐生市市民文化会館　群馬   Country：Japan  

Event date： 2017.9

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：東京大学理学系研究科化学講堂　東京   Country：Japan  

Event date： 2017.9

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：千葉大学亥鼻キャンパス医薬系総合研究棟II地下大会議室　千葉   Country：Japan  

Event date： 2017.9

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：金沢文化ホール　石川   Country：Japan  

Event date： 2017.8

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：秋保リゾートホテルクレセント　宮城   Country：Japan  

Event date： 2017.8

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：長崎ブルースカイホテル　長崎   Country：Japan  

Event date： 2017.6

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：産業技術総合研究所　茨城   Country：Japan  

Event date： 2017.6

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Hotel Continental Saigon Saigon Vietnam   Country：Viet Nam  

Event date： 2017.3

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：慶應義塾大学　神奈川   Country：Japan  

Event date： 2017.3

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Keio University Kanagawa Japan   Country：Japan  

Event date： 2016.12

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：和光純薬工業株式会社　湯河原研修所　神奈川   Country：Japan  

Event date： 2016.11

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：タワーホール船堀　東京   Country：Japan  

Event date： 2016.11

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：ダイキン工業株式会社　淀川製作所テクノロジー・イノベーションセンター　大阪   Country：Japan  

Event date： 2016.9

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：東京工業大学　蔵前会館　東京   Country：Japan  

Event date： 2016.8

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Tokyo Institute of Technology Tokyo Japan   Country：Japan  

Event date： 2015.12

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：京都大学桂キャンパス　京都   Country：Japan  

Event date： 2015.10

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Birla Institute of Technology and Science India   Country：India  

Event date： 2015.3

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：日本大学船橋キャンパス　千葉   Country：Japan  

Event date： 2014.12

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：National Univeristy of Singapore Singapore   Country：Singapore  

Event date： 2014.8

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：京都大学　京都   Country：Japan  

Event date： 2013.11

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Todaiji Temple Cultural Center Nara Japan   Country：Japan  

Event date： 2013.6

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：日本科学未来館　東京   Country：Japan  

Event date： 2013.3

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：東北大学川内北キャンパス　宮城   Country：Japan  

Event date： 2013.2

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：かんぽの宿　福井   Country：Japan  

Event date： 2012.3

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：大阪科学技術センター　大阪   Country：Japan  

Event date： 2011.11

Language：English   Presentation type：Oral presentation (invited, special)  

Venue：Tokyo Institute of Technology Tokyo Japan   Country：Japan  

Event date： 2011.10

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：星薬科大学　東京   Country：Japan  

Event date： 2007.7

Language：Japanese   Presentation type：Oral presentation (invited, special)  

Venue：秋保リゾートホテル　クレセント　宮城   Country：Japan