Organization
Graduate School of Medicine Designated associate professor
Title
Designated associate professor
External link
SEO Wooseok
Degree 2
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PhD （ 2008.4 The University of British Columbia ）
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MSc （ 2002.11 University of Calgary ）
Research Interests 4
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Chromatin Structure
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Epigenetics
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Transcriptional Regulation
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T cell
Research Areas 2
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Life Science / Molecular biology / Gene Expression
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Life Science / Immunology / T cell immunity
Research History 4
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Nagoya University Institute for Advanced Study, Young Researcher Unit Unit Leader
2023.4
Country：Japan
Notes：http://www.iar.nagoya-u.ac.jp/eng/actions/
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Nagoya University Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Designated associate professor
2019.11
Country：Japan
Notes：https://www.med.nagoya-u.ac.jp/medical_E/laboratory/basic-med/micro-immunology/immunology/
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RIKEN Researcher
2009.11 - 2019.10
Country：Japan
Notes：https://www.ims.riken.jp/english/index.php
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University of British Columbia Biomedical Research Centre Researcher
2008.5 - 2009.10
Country：Canada
Notes：https://www.ubc.ca/
Education 2
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University of British Columbia PhD Department of Medicine
- 2008.4
Country： Canada
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University of Calgary MSc Department of Biological Sciences
- 2002.11
Country： Canada
Professional Memberships 2
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Japanese Society of Cancer
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Japanese Society of Immunology
Papers 26
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Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s
Nomura Aneela, Kobayashi Tetsuro, Seo Wooseok, Ohno-Oishi Michiko, Kakugawa Kiyokazu, Muroi Sawako, Yoshida Hideyuki, Endo Takaho A., Moro Kazuyo, Taniuchi Ichiro
LIFE SCIENCE ALLIANCE Vol. 6 ( 8 ) 2023.8
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Impact of particulate microplastics generated from polyethylene terephthalate on gut pathology and immune microenvironments
Harusato Akihito, Seo Wooseok, Abo Hirohito, Nakanishi Yoshitaka, Nishikawa Hiroyoshi, Itoh Yoshito
ISCIENCE Vol. 26 ( 4 ) 2023.4
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Dietary Emulsifiers Exacerbate Food Allergy and Colonic Type 2 Immune Response through Microbiota Modulation
Harusato Akihito, Chassaing Benoit, Dauriat Charlene J. G., Ushiroda Chihiro, Seo Wooseok, Itoh Yoshito
NUTRIENTS Vol. 14 ( 23 ) 2022.12
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The Roles of RUNX Proteins in Lymphocyte Function and Anti-Tumor Immunity
Seo Wooseok, Nomura Aneela, Taniuchi Ichiro
CELLS Vol. 11 ( 19 ) 2022.10
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Transcriptional regulatory network for the establishment of CD8(+) T cell exhaustion
Seo Wooseok, Jerin Chandsultana, Nishikawa Hiroyoshi
EXPERIMENTAL AND MOLECULAR MEDICINE Vol. 53 ( 2 ) page： 202 - 209 2021.2
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Seo Wooseok, Shimizu Kanako, Kojo Satoshi, Okeke Arinze, Kohwi-Shigematsu Terumi, Fujii Shin-ichiro, Taniuchi Ichiro
NATURE COMMUNICATIONS Vol. 11 ( 1 ) 2020.3
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Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells
Kojo Satoshi, Ohno-Oishi Michiko, Wada Hisashi, Nieke Sebastian, Seo Wooseok, Muroi Sawako, Taniuchi Ichiro
LIFE SCIENCE ALLIANCE Vol. 3 ( 2 ) 2020.2
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The Roles of RUNX Family Proteins in Development of Immune Cells.
Seo W, Taniuchi I
Molecules and cells 2020.1
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Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt<sup>+</sup> T cells.
Vol. 3 ( 1 ) 2020.1
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Too much can be as bad as too little.
Seo W, Taniuchi I
Nature immunology Vol. 20 ( 10 ) page： 1262-1264 2019.10
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Tle corepressors are differentially partitioned to instruct CD8<sup>+</sup> T cell lineage choice and identity.
Xing S, Shao P, Li F, Zhao X, Seo W, Wheat JC, Ramasamy S, Wang J, Li X, Peng W, Yu S, Liu C, Taniuchi I, Sweetser DA, Xue HH
The Journal of experimental medicine Vol. 215 ( 8 ) page： 2211-2226 2018.8
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Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.
Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I
Nature communications Vol. 8 ( 1 ) page： 702 2017.9
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Essential Roles of SATB1 in Specifying T Lymphocyte Subsets.
Kakugawa K, Kojo S, Tanaka H, Seo W, Endo TA, Kitagawa Y, Muroi S, Tenno M, Yasmin N, Kohwi Y, Sakaguchi S, Kowhi-Shigematsu T, Taniuchi I
Cell reports Vol. 19 ( 6 ) page： 1176-1188 2017.5
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Regulation of hematopoiesis and immune responses by long non-coding RNAs.
Seo W, Taniuchi I
International immunology Vol. 29 ( 4 ) page： 165-172 2017.4
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Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages.
Vol. 7 page： 41351 2017.2
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Roles of RUNX Complexes in Immune Cell Development.
Ebihara T, Seo W, Taniuchi I
Advances in experimental medicine and biology Vol. 962 page： 395-413 2017
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Transcriptional regulation of early T-cell development in the thymus
Seo Wooseok, Taniuchi Ichiro
EUROPEAN JOURNAL OF IMMUNOLOGY Vol. 46 ( 3 ) page： 531 - 538 2016.3
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Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbf beta for their development
Kobayashi Michihiro, Shelley W. Christopher, Seo Wooseok, Vemula Sasidhar, Lin Yang, Liu Yan, Kapur Reuben, Taniuchi Ichiro, Yoshimoto Momoko
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 111 ( 33 ) page： 12151 - 12156 2014.8
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Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus
Tanaka Hirokazu, Naito Taku, Muroi Sawako, Seo Wooseok, Chihara Risa, Miyamoto Chizuko, Kominami Ryo, Taniuchi Ichiro
EMBO JOURNAL Vol. 32 ( 8 ) page： 1183 - 1194 2013.4
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Roles of VWRPY motif-mediated gene repression by Runx proteins during T-cell development
Seo Wooseok, Tanaka Hirokazu, Miyamoto Chizuko, Levanon Ditsa, Groner Yoram, Taniuchi Ichiro
IMMUNOLOGY AND CELL BIOLOGY Vol. 90 ( 8 ) page： 827 - 830 2012.9
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Runx1-Cbf beta facilitates early B lymphocyte development by regulating expression of Ebf1
Seo Wooseok, Ikawa Tomokatsu, Kawamoto Hiroshi, Taniuchi Ichiro
JOURNAL OF EXPERIMENTAL MEDICINE Vol. 209 ( 7 ) page： 1255 - 1262 2012.7
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CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis
Seo Wooseok, Ziltener Hermann J.
BLOOD Vol. 114 ( 17 ) page： 3567 - 3577 2009.10
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PSGL-1 function in immunity and steady state homeostasis
Carlow Douglas A., Gossens Klaus, Naus Silvia, Veerman Krystle M., Seo Wooseok, Ziltener Hermann J.
IMMUNOLOGICAL REVIEWS Vol. 230 page： 75 - 96 2009.7
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Insertion of group II intron retroelements after intrinsic transcriptional terminators
Robart Aaron R., Seo Wooseok, Zimmerly Steven
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 104 ( 16 ) page： 6620 - 6625 2007.4
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CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution
Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM
IMMUNITY Vol. 22 ( 1 ) page： 43 - 57 2005.1
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Non-cognate template usage and alternative priming by a group II intron-encoded reverse transcriptase
Morozova T, Seo W, Zimmerly S
JOURNAL OF MOLECULAR BIOLOGY Vol. 315 ( 5 ) page： 951 - 963 2002.2
Research Project for Joint Research, Competitive Funding, etc. 2
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遺伝子位置情報から遺伝子機能予測 - 「転写ファクトリー」概念の立証研究
2023.4 - 2026.3
創発的研究支援事業フェーズ１
SEO Wooseok
Authorship：Principal investigator Grant type：Competitive
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ゲノムオーガナイザーSatb1によるT細胞の老化制御機構
2023.4 - 2024.3
堀科学芸術振興財団研究助成 基礎研究
SEO Wooseok
Authorship：Principal investigator Grant type：Competitive
Grant amount：\2000000
KAKENHI (Grants-in-Aid for Scientific Research) 6
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The regulatory mechanism of T cell exhaustion by genomic organizer Satb1
Grant number：23K06581 2023.4 - 2026.3
Nagoya University Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Scientific Research (C)
SEO Wooseok
Grant type：Competitive
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Intestinal homeostasis and the mechanism of food allergy
Grant number：22K11731 2022.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
HARUSATO Akihito, SEO Wooseok
Authorship：Coinvestigator(s)
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Regulatory mechanisms controlling CCL5 chemokine to maintain tissue homeostasis
Grant number：18K07186 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
SEO Wooseok
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
CCL5 is an important inflammatory chemokine and used to recruit immune cells to the infected sites to clear pathogens. Recent studies have suggested that CCL5 also functions to maintain tissue-resident immune cells within local tissues,
thus implying that CCL5 can function under both inflammatory and non-inflammatory situations.
During the thorough examination to decipher the detailed molecular regulatory circuit responsible for the specific expression of CCL5 in both inflammatory and non-inflammatory situations, I discovered that previously unknown two transcriptional enhancers, each of which is responsible for the expression of CCL5 in inflammatory and non-inflammatory situations. By the generation two gene-modified mouse lines in which either of enhancer is knocked out, I concluded that these two enhancers gives the temporal specificity of CCL5 expression by mediating chromatin loop between them. -
Runx-mediated regulation of chemokine CCL5 for lung diseases
Grant number：15K08535 2015.4 - 2018.3
Grant-in-Aid for Scientific Research (C)
SEO Wooseok
Authorship：Principal investigator
Grant amount：\4550000 （ Direct Cost: \3500000 、 Indirect Cost：\1050000 ）
CCL5 chemokine is related to the development of many inflammatory diseases. To understand how CCL5 is regulated, I have examined a knockout mouse of Runx/CBFβ transcription factor and discovered that CCL5 is hugely upregulated in the absence of Runx/CBFβ. This indicated that CCL5 is tightly regulated by Runx/CBFβ. By combining regular ChIP and novel enChIP assays, I discovered that CCL5 expression requires two separate enhancers depending on activation states. These enhancers are crucial for proper expression of CCL5 from T cells as well as T-cell immunity.
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Effects of Runx1-associated lncRNA on asthma pathogenesis
Grant number：25860374 2013.4 - 2015.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
SEO Wooseok
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
Runx1 knockout mice spontaneously develop lung inflammation resembling human asthma; however, its mechanism is not known yet. Examination of Runx1 locus shows a long non-coding RNA (lncRNA) located near Runx1 gene. This novel lncRNA shows a very low expression, but it is restricted to helper T lymphocytes. Knockdown of Runx1-lncRNA shows differential expressions of Runx1 target genes. Also, Runx1-lncRNA knockout mouse develops lung pathologies similar to Runx1 knockout mice. Therefore, we conclude that Runx1-lncRNA is functionally related to Runx1 protein.
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RunxタンパクVWRPY配列を介した免疫細胞分化制御機構の解明
Grant number：10F00516 2010.10 - 2013.3
科学研究費助成事業
セオ ウセオク
Authorship：Principal investigator
Grant amount：\2200000
Teaching Experience (On-campus) 4
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Immunology and Host Defense System
2023
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Immunology and Host Defense System
2022
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Immunology and Host Defense System
2021
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Immunology and Host Defense System
2020