Updated on 2021/12/07

写真a

 
SEO Wooseok
 
Organization
Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Designated associate professor
Title
Designated associate professor

Degree 2

  1. PhD ( 2008.4 ) 

  2. MSc ( 2002.11 ) 

Research Interests 2

  1. Transcriptional Regulation

  2. Cancer Immunology

Research Areas 2

  1. Life Science / Molecular biology  / Transcriptional Regulation

  2. Life Science / Immunology  / Cancer Immunology

Research History 2

  1. RIKEN   Researcher

    2009.11 - 2019.10

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    Country:Japan

  2. University of British Columbia   Biomedical Research Centre   Researcher

    2008.5 - 2009.10

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    Country:Canada

Education 2

  1. University of British Columbia   Department of Medicine

    - 2008.4

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    Country: Canada

  2. University of Calgary   Department of Biological Sciences

    - 2002.11

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    Country: Canada

 

Papers 22

  1. Transcriptional regulatory network for the establishment of CD8(+) T cell exhaustion

    Seo Wooseok, Jerin Chandsultana, Nishikawa Hiroyoshi

    EXPERIMENTAL AND MOLECULAR MEDICINE     2021.2

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s12276-021-00568-0

    Web of Science

  2. Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

    Seo Wooseok, Shimizu Kanako, Kojo Satoshi, Okeke Arinze, Kohwi-Shigematsu Terumi, Fujii Shin-ichiro, Taniuchi Ichiro

    NATURE COMMUNICATIONS   Vol. 11 ( 1 )   2020.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-020-15375-w

    Web of Science

    Scopus

  3. Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells

    Kojo Satoshi, Ohno-Oishi Michiko, Wada Hisashi, Nieke Sebastian, Seo Wooseok, Muroi Sawako, Taniuchi Ichiro

    LIFE SCIENCE ALLIANCE   Vol. 3 ( 2 )   2020.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Life Science Alliance  

    Temporal down-regulation of the CD8 co-receptor after receiving positive-selection signals has been proposed to serve as an important determinant to segregate helper versus cytotoxic lineages by generating differences in the duration of TCR signaling between MHC-I and MHC-II selected thymocytes. By contrast, little is known about whether CD8 also modulates TCR signaling engaged by the non-classical MHC-I–like molecule, CD1d, during development of invariant natural killer T (iNKT) cells. Here, we show that constitutive transgenic CD8 expression resulted in enhanced differentiation of innate memory-like CD8+ thymocytes in both a cell-intrinsic and cell-extrinsic manner, the latter being accomplished by an increase in the IL-4–producing iNKT2 subset. Skewed iNKT2 differentiation requires cysteine residues in the intracellular domain of CD8α that are essential for transmitting cellular signaling. Collectively, these findings shed a new light on the relevance of CD8 down-regulation in shaping the balance of iNKT-cell subsets by modulating TCR signaling.

    DOI: 10.26508/lsa.202000642

    Web of Science

    Scopus

  4. The Roles of RUNX Family Proteins in Development of Immune Cells.

    Seo W, Taniuchi I

    Molecules and cells     2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.14348/molcells.2019.0291

    PubMed

  5. Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt<sup>+</sup> T cells.

      Vol. 3 ( 1 )   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.26508/lsa.201900441

    PubMed

  6. Too much can be as bad as too little.

    Seo W, Taniuchi I

    Nature immunology   Vol. 20 ( 10 ) page: 1262-1264   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41590-019-0498-7

    PubMed

  7. Tle corepressors are differentially partitioned to instruct CD8<sup>+</sup> T cell lineage choice and identity.

    Xing S, Shao P, Li F, Zhao X, Seo W, Wheat JC, Ramasamy S, Wang J, Li X, Peng W, Yu S, Liu C, Taniuchi I, Sweetser DA, Xue HH

    The Journal of experimental medicine   Vol. 215 ( 8 ) page: 2211-2226   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20171514

    PubMed

  8. Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.

    Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I

    Nature communications   Vol. 8 ( 1 ) page: 702   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-017-00768-1

    PubMed

  9. Essential Roles of SATB1 in Specifying T Lymphocyte Subsets.

    Kakugawa K, Kojo S, Tanaka H, Seo W, Endo TA, Kitagawa Y, Muroi S, Tenno M, Yasmin N, Kohwi Y, Sakaguchi S, Kowhi-Shigematsu T, Taniuchi I

    Cell reports   Vol. 19 ( 6 ) page: 1176-1188   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2017.04.038

    PubMed

  10. Regulation of hematopoiesis and immune responses by long non-coding RNAs.

    Seo W, Taniuchi I

    International immunology   Vol. 29 ( 4 ) page: 165-172   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/dxx021

    PubMed

  11. Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages.

      Vol. 7   page: 41351   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep41351

    PubMed

  12. Roles of RUNX Complexes in Immune Cell Development.

    Ebihara T, Seo W, Taniuchi I

    Advances in experimental medicine and biology   Vol. 962   page: 395-413   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/978-981-10-3233-2_24

    PubMed

  13. Transcriptional regulation of early T-cell development in the thymus

    Seo Wooseok, Taniuchi Ichiro

    EUROPEAN JOURNAL OF IMMUNOLOGY   Vol. 46 ( 3 ) page: 531 - 538   2016.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/eji.201545821

    Web of Science

  14. Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbf beta for their development

    Kobayashi Michihiro, Shelley W. Christopher, Seo Wooseok, Vemula Sasidhar, Lin Yang, Liu Yan, Kapur Reuben, Taniuchi Ichiro, Yoshimoto Momoko

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 111 ( 33 ) page: 12151 - 12156   2014.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1407370111

    Web of Science

  15. Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus

    Tanaka Hirokazu, Naito Taku, Muroi Sawako, Seo Wooseok, Chihara Risa, Miyamoto Chizuko, Kominami Ryo, Taniuchi Ichiro

    EMBO JOURNAL   Vol. 32 ( 8 ) page: 1183 - 1194   2013.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/emboj.2013.47

    Web of Science

  16. Roles of VWRPY motif-mediated gene repression by Runx proteins during T-cell development

    Seo Wooseok, Tanaka Hirokazu, Miyamoto Chizuko, Levanon Ditsa, Groner Yoram, Taniuchi Ichiro

    IMMUNOLOGY AND CELL BIOLOGY   Vol. 90 ( 8 ) page: 827 - 830   2012.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/icb.2012.6

    Web of Science

  17. Runx1-Cbf beta facilitates early B lymphocyte development by regulating expression of Ebf1

    Seo Wooseok, Ikawa Tomokatsu, Kawamoto Hiroshi, Taniuchi Ichiro

    JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 209 ( 7 ) page: 1255 - 1262   2012.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20112745

    Web of Science

  18. CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis

    Seo Wooseok, Ziltener Hermann J.

    BLOOD   Vol. 114 ( 17 ) page: 3567 - 3577   2009.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2009-06-228791

    Web of Science

  19. PSGL-1 function in immunity and steady state homeostasis

    Carlow Douglas A., Gossens Klaus, Naus Silvia, Veerman Krystle M., Seo Wooseok, Ziltener Hermann J.

    IMMUNOLOGICAL REVIEWS   Vol. 230   page: 75 - 96   2009.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Web of Science

  20. Insertion of group II intron retroelements after intrinsic transcriptional terminators

    Robart Aaron R., Seo Wooseok, Zimmerly Steven

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 104 ( 16 ) page: 6620 - 6625   2007.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.0700561104

    Web of Science

  21. CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution

    Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM

    IMMUNITY   Vol. 22 ( 1 ) page: 43 - 57   2005.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.immuni.2004.11.014

    Web of Science

  22. Non-cognate template usage and alternative priming by a group II intron-encoded reverse transcriptase

    Morozova T, Seo W, Zimmerly S

    JOURNAL OF MOLECULAR BIOLOGY   Vol. 315 ( 5 ) page: 951 - 963   2002.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/jmbi.2001.5320

    Web of Science

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. Regulatory mechanisms controlling CCL5 chemokine to maintain tissue homeostasis

    Grant number:18K07186  2018.4 - 2021.3

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

  2. Runx-mediated regulation of chemokine CCL5 for lung diseases

    Grant number:15K08535  2015.10 - 2018.3

    Grant-in-Aid for Scientific Research (C)

    Seo Wooseok

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    CCL5 chemokine is related to the development of many inflammatory diseases. To understand how CCL5 is regulated, I have examined a knockout mouse of Runx/CBFβ transcription factor and discovered that CCL5 is hugely upregulated in the absence of Runx/CBFβ. This indicated that CCL5 is tightly regulated by Runx/CBFβ. By combining regular ChIP and novel enChIP assays, I discovered that CCL5 expression requires two separate enhancers depending on activation states. These enhancers are crucial for proper expression of CCL5 from T cells as well as T-cell immunity.

  3. Effects of Runx1-associated lncRNA on asthma pathogenesis

    Grant number:25860374  2013.4 - 2015.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    SEO WOOSEOK

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Runx1 knockout mice spontaneously develop lung inflammation resembling human asthma; however, its mechanism is not known yet. Examination of Runx1 locus shows a long non-coding RNA (lncRNA) located near Runx1 gene. This novel lncRNA shows a very low expression, but it is restricted to helper T lymphocytes. Knockdown of Runx1-lncRNA shows differential expressions of Runx1 target genes. Also, Runx1-lncRNA knockout mouse develops lung pathologies similar to Runx1 knockout mice. Therefore, we conclude that Runx1-lncRNA is functionally related to Runx1 protein.