Updated on 2023/08/01

写真a

 
SEO Wooseok
 
Organization
Graduate School of Medicine Designated associate professor
Title
Designated associate professor
External link

Degree 2

  1. PhD ( 2008.4   The University of British Columbia ) 

  2. MSc ( 2002.11   University of Calgary ) 

Research Interests 4

  1. Chromatin Structure

  2. Epigenetics

  3. Transcriptional Regulation

  4. T cell

Research Areas 2

  1. Life Science / Molecular biology  / Gene Expression

  2. Life Science / Immunology  / T cell immunity

Research History 4

  1. Nagoya University   Institute for Advanced Study, Young Researcher Unit   Unit Leader

    2023.4

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    Country:Japan

    Notes:http://www.iar.nagoya-u.ac.jp/eng/actions/

  2. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology   Designated associate professor

    2019.11

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    Country:Japan

    Notes:https://www.med.nagoya-u.ac.jp/medical_E/laboratory/basic-med/micro-immunology/immunology/

  3. RIKEN   Researcher

    2009.11 - 2019.10

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    Country:Japan

    Notes:https://www.ims.riken.jp/english/index.php

  4. University of British Columbia   Biomedical Research Centre   Researcher

    2008.5 - 2009.10

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    Country:Canada

    Notes:https://www.ubc.ca/

Education 2

  1. University of British Columbia   PhD   Department of Medicine

    - 2008.4

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    Country: Canada

  2. University of Calgary   MSc   Department of Biological Sciences

    - 2002.11

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    Country: Canada

Professional Memberships 2

  1. Japanese Society of Cancer

  2. Japanese Society of Immunology

 

Papers 26

  1. Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s

    Nomura Aneela, Kobayashi Tetsuro, Seo Wooseok, Ohno-Oishi Michiko, Kakugawa Kiyokazu, Muroi Sawako, Yoshida Hideyuki, Endo Takaho A., Moro Kazuyo, Taniuchi Ichiro

    LIFE SCIENCE ALLIANCE   Vol. 6 ( 8 )   2023.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.26508/lsa.202301897

    Web of Science

  2. Impact of particulate microplastics generated from polyethylene terephthalate on gut pathology and immune microenvironments

    Harusato Akihito, Seo Wooseok, Abo Hirohito, Nakanishi Yoshitaka, Nishikawa Hiroyoshi, Itoh Yoshito

    ISCIENCE   Vol. 26 ( 4 )   2023.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.isci.2023.106474

    Web of Science

  3. Dietary Emulsifiers Exacerbate Food Allergy and Colonic Type 2 Immune Response through Microbiota Modulation

    Harusato Akihito, Chassaing Benoit, Dauriat Charlene J. G., Ushiroda Chihiro, Seo Wooseok, Itoh Yoshito

    NUTRIENTS   Vol. 14 ( 23 )   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/nu14234983

    Web of Science

  4. The Roles of RUNX Proteins in Lymphocyte Function and Anti-Tumor Immunity

    Seo Wooseok, Nomura Aneela, Taniuchi Ichiro

    CELLS   Vol. 11 ( 19 )   2022.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cells11193116

    Web of Science

  5. Transcriptional regulatory network for the establishment of CD8(+) T cell exhaustion

    Seo Wooseok, Jerin Chandsultana, Nishikawa Hiroyoshi

    EXPERIMENTAL AND MOLECULAR MEDICINE   Vol. 53 ( 2 ) page: 202 - 209   2021.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Experimental and Molecular Medicine  

    Chronic infection with persistent antigenic stimulation results in the generation of exhausted CD8+ T cells, which are considered defective effector CD8+ T cells, and thus compromises effective immune responses. However, recent studies have illustrated that exhausted CD8+ T cells may be purposely generated and maintained to provide mild immune responses against chronic infection or cancer, which can be safer over a long period of time than strong immune responses. Indeed, a specific population of exhausted CD8+ T cells that behaves similarly to self-renewing stem cells and provides a continuous supply of exhausted CD8+ T cells has been identified, indicating that this population can be considered progenitors of exhausted CD8+ T cells. Furthermore, several ground-breaking studies in the last few years have shed new light on the transcriptional regulatory network governing the generation and propagation of exhausted CD8+ T cells, which involves T cell receptor (TCR) signaling that leads to NFAT-TCF1 (nuclear factor of activated T cells-T cell factor 1) activity followed by activation of the TOX/NR4A axis. Elucidation of the intracellular signaling pathways will help to define the definitive developmental stages leading to exhausted CD8+ T cells, which can be exploited to advance our never-ending battle against cancer. This review will summarize the recent discoveries that have deepened our understanding of the exhaustion program of cytotoxic CD8+ T cells.

    DOI: 10.1038/s12276-021-00568-0

    Web of Science

    Scopus

  6. Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity

    Seo Wooseok, Shimizu Kanako, Kojo Satoshi, Okeke Arinze, Kohwi-Shigematsu Terumi, Fujii Shin-ichiro, Taniuchi Ichiro

    NATURE COMMUNICATIONS   Vol. 11 ( 1 )   2020.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-020-15375-w

    Web of Science

    Scopus

  7. Constitutive CD8 expression drives innate CD8(+) T-cell differentiation via induction of iNKT2 cells

    Kojo Satoshi, Ohno-Oishi Michiko, Wada Hisashi, Nieke Sebastian, Seo Wooseok, Muroi Sawako, Taniuchi Ichiro

    LIFE SCIENCE ALLIANCE   Vol. 3 ( 2 )   2020.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Life Science Alliance  

    © 2020 Kojo et al. Temporal down-regulation of the CD8 co-receptor after receiving positive-selection signals has been proposed to serve as an important determinant to segregate helper versus cytotoxic lineages by generating differences in the duration of TCR signaling between MHC-I and MHC-II selected thymocytes. By contrast, little is known about whether CD8 also modulates TCR signaling engaged by the non-classical MHC-I–like molecule, CD1d, during development of invariant natural killer T (iNKT) cells. Here, we show that constitutive transgenic CD8 expression resulted in enhanced differentiation of innate memory-like CD8+ thymocytes in both a cell-intrinsic and cell-extrinsic manner, the latter being accomplished by an increase in the IL-4–producing iNKT2 subset. Skewed iNKT2 differentiation requires cysteine residues in the intracellular domain of CD8α that are essential for transmitting cellular signaling. Collectively, these findings shed a new light on the relevance of CD8 down-regulation in shaping the balance of iNKT-cell subsets by modulating TCR signaling.

    DOI: 10.26508/lsa.202000642

    Web of Science

    Scopus

  8. The Roles of RUNX Family Proteins in Development of Immune Cells.

    Seo W, Taniuchi I

    Molecules and cells     2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.14348/molcells.2019.0291

    PubMed

  9. Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt<sup>+</sup> T cells.

      Vol. 3 ( 1 )   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.26508/lsa.201900441

    PubMed

  10. Too much can be as bad as too little.

    Seo W, Taniuchi I

    Nature immunology   Vol. 20 ( 10 ) page: 1262-1264   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41590-019-0498-7

    PubMed

  11. Tle corepressors are differentially partitioned to instruct CD8<sup>+</sup> T cell lineage choice and identity.

    Xing S, Shao P, Li F, Zhao X, Seo W, Wheat JC, Ramasamy S, Wang J, Li X, Peng W, Yu S, Liu C, Taniuchi I, Sweetser DA, Xue HH

    The Journal of experimental medicine   Vol. 215 ( 8 ) page: 2211-2226   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20171514

    PubMed

  12. Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.

    Kojo S, Tanaka H, Endo TA, Muroi S, Liu Y, Seo W, Tenno M, Kakugawa K, Naoe Y, Nair K, Moro K, Katsuragi Y, Kanai A, Inaba T, Egawa T, Venkatesh B, Minoda A, Kominami R, Taniuchi I

    Nature communications   Vol. 8 ( 1 ) page: 702   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-017-00768-1

    PubMed

  13. Essential Roles of SATB1 in Specifying T Lymphocyte Subsets.

    Kakugawa K, Kojo S, Tanaka H, Seo W, Endo TA, Kitagawa Y, Muroi S, Tenno M, Yasmin N, Kohwi Y, Sakaguchi S, Kowhi-Shigematsu T, Taniuchi I

    Cell reports   Vol. 19 ( 6 ) page: 1176-1188   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.celrep.2017.04.038

    PubMed

  14. Regulation of hematopoiesis and immune responses by long non-coding RNAs.

    Seo W, Taniuchi I

    International immunology   Vol. 29 ( 4 ) page: 165-172   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/intimm/dxx021

    PubMed

  15. Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages.

      Vol. 7   page: 41351   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep41351

    PubMed

  16. Roles of RUNX Complexes in Immune Cell Development.

    Ebihara T, Seo W, Taniuchi I

    Advances in experimental medicine and biology   Vol. 962   page: 395-413   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/978-981-10-3233-2_24

    PubMed

  17. Transcriptional regulation of early T-cell development in the thymus

    Seo Wooseok, Taniuchi Ichiro

    EUROPEAN JOURNAL OF IMMUNOLOGY   Vol. 46 ( 3 ) page: 531 - 538   2016.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/eji.201545821

    Web of Science

  18. Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbf beta for their development

    Kobayashi Michihiro, Shelley W. Christopher, Seo Wooseok, Vemula Sasidhar, Lin Yang, Liu Yan, Kapur Reuben, Taniuchi Ichiro, Yoshimoto Momoko

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 111 ( 33 ) page: 12151 - 12156   2014.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.1407370111

    Web of Science

  19. Epigenetic Thpok silencing limits the time window to choose CD4(+) helper-lineage fate in the thymus

    Tanaka Hirokazu, Naito Taku, Muroi Sawako, Seo Wooseok, Chihara Risa, Miyamoto Chizuko, Kominami Ryo, Taniuchi Ichiro

    EMBO JOURNAL   Vol. 32 ( 8 ) page: 1183 - 1194   2013.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/emboj.2013.47

    Web of Science

  20. Roles of VWRPY motif-mediated gene repression by Runx proteins during T-cell development

    Seo Wooseok, Tanaka Hirokazu, Miyamoto Chizuko, Levanon Ditsa, Groner Yoram, Taniuchi Ichiro

    IMMUNOLOGY AND CELL BIOLOGY   Vol. 90 ( 8 ) page: 827 - 830   2012.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/icb.2012.6

    Web of Science

  21. Runx1-Cbf beta facilitates early B lymphocyte development by regulating expression of Ebf1

    Seo Wooseok, Ikawa Tomokatsu, Kawamoto Hiroshi, Taniuchi Ichiro

    JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 209 ( 7 ) page: 1255 - 1262   2012.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1084/jem.20112745

    Web of Science

  22. CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis

    Seo Wooseok, Ziltener Hermann J.

    BLOOD   Vol. 114 ( 17 ) page: 3567 - 3577   2009.10

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1182/blood-2009-06-228791

    Web of Science

  23. PSGL-1 function in immunity and steady state homeostasis

    Carlow Douglas A., Gossens Klaus, Naus Silvia, Veerman Krystle M., Seo Wooseok, Ziltener Hermann J.

    IMMUNOLOGICAL REVIEWS   Vol. 230   page: 75 - 96   2009.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Web of Science

  24. Insertion of group II intron retroelements after intrinsic transcriptional terminators

    Robart Aaron R., Seo Wooseok, Zimmerly Steven

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   Vol. 104 ( 16 ) page: 6620 - 6625   2007.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.0700561104

    Web of Science

  25. CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution

    Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM

    IMMUNITY   Vol. 22 ( 1 ) page: 43 - 57   2005.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.immuni.2004.11.014

    Web of Science

  26. Non-cognate template usage and alternative priming by a group II intron-encoded reverse transcriptase

    Morozova T, Seo W, Zimmerly S

    JOURNAL OF MOLECULAR BIOLOGY   Vol. 315 ( 5 ) page: 951 - 963   2002.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/jmbi.2001.5320

    Web of Science

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Research Project for Joint Research, Competitive Funding, etc. 2

  1. 遺伝子位置情報から遺伝子機能予測 - 「転写ファクトリー」概念の立証研究

    2023.4 - 2026.3

    創発的研究支援事業フェーズ1 

    SEO Wooseok

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    Authorship:Principal investigator  Grant type:Competitive

  2. ゲノムオーガナイザーSatb1によるT細胞の老化制御機構

    2023.4 - 2024.3

    堀科学芸術振興財団研究助成  基礎研究

    SEO Wooseok

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. The regulatory mechanism of T cell exhaustion by genomic organizer Satb1

    Grant number:23K06581  2023.4 - 2026.3

    Nagoya University  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Scientific Research (C)

    SEO Wooseok

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    Grant type:Competitive

  2. Intestinal homeostasis and the mechanism of food allergy

    Grant number:22K11731  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    HARUSATO Akihito, SEO Wooseok

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    Authorship:Coinvestigator(s) 

  3. Regulatory mechanisms controlling CCL5 chemokine to maintain tissue homeostasis

    Grant number:18K07186  2018.4 - 2021.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    SEO Wooseok

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    CCL5 is an important inflammatory chemokine and used to recruit immune cells to the infected sites to clear pathogens. Recent studies have suggested that CCL5 also functions to maintain tissue-resident immune cells within local tissues,
    thus implying that CCL5 can function under both inflammatory and non-inflammatory situations.
    During the thorough examination to decipher the detailed molecular regulatory circuit responsible for the specific expression of CCL5 in both inflammatory and non-inflammatory situations, I discovered that previously unknown two transcriptional enhancers, each of which is responsible for the expression of CCL5 in inflammatory and non-inflammatory situations. By the generation two gene-modified mouse lines in which either of enhancer is knocked out, I concluded that these two enhancers gives the temporal specificity of CCL5 expression by mediating chromatin loop between them.

  4. Runx-mediated regulation of chemokine CCL5 for lung diseases

    Grant number:15K08535  2015.4 - 2018.3

    Grant-in-Aid for Scientific Research (C)

    SEO Wooseok

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    CCL5 chemokine is related to the development of many inflammatory diseases. To understand how CCL5 is regulated, I have examined a knockout mouse of Runx/CBFβ transcription factor and discovered that CCL5 is hugely upregulated in the absence of Runx/CBFβ. This indicated that CCL5 is tightly regulated by Runx/CBFβ. By combining regular ChIP and novel enChIP assays, I discovered that CCL5 expression requires two separate enhancers depending on activation states. These enhancers are crucial for proper expression of CCL5 from T cells as well as T-cell immunity.

  5. Effects of Runx1-associated lncRNA on asthma pathogenesis

    Grant number:25860374  2013.4 - 2015.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    SEO Wooseok

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Runx1 knockout mice spontaneously develop lung inflammation resembling human asthma; however, its mechanism is not known yet. Examination of Runx1 locus shows a long non-coding RNA (lncRNA) located near Runx1 gene. This novel lncRNA shows a very low expression, but it is restricted to helper T lymphocytes. Knockdown of Runx1-lncRNA shows differential expressions of Runx1 target genes. Also, Runx1-lncRNA knockout mouse develops lung pathologies similar to Runx1 knockout mice. Therefore, we conclude that Runx1-lncRNA is functionally related to Runx1 protein.

  6. RunxタンパクVWRPY配列を介した免疫細胞分化制御機構の解明

    Grant number:10F00516  2010.10 - 2013.3

    科学研究費助成事業  

    セオ ウセオク

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    Authorship:Principal investigator 

    Grant amount:\2200000

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Teaching Experience (On-campus) 4

  1. Immunology and Host Defense System

    2023

  2. Immunology and Host Defense System

    2022

  3. Immunology and Host Defense System

    2021

  4. Immunology and Host Defense System

    2020