Faculty Profiles - CHEN-YOSHIKAWA Toyofumi

Papers - CHEN-YOSHIKAWA Toyofumi

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ABO blood type incompatible lung transplantation. Reviewed International journal

Toyofumi F Chen-Yoshikawa

Journal of thoracic disease Vol. 15 ( 6 ) page： 3437 - 3442 2023.6

Authorship：Lead author,　Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

ABO-incompatible transplantation has been successfully performed in the kidney and liver. However, lungs are subject to strong rejection and are vulnerable to infection because they are directly exposed to air. Therefore, lung transplantation from organs with incompatible blood types has been considered a significant challenge. Due to the severe shortage of donors, ABO-incompatible lung transplantation might be a viable method to save critically ill patients with end-stage respiratory diseases. Herein, we review the worldwide published reports about both minor and major ABO-incompatible lung transplantations. In North America, major ABO-incompatible lung transplants have been performed in cases with clerical errors in blood typing. But they were successful with additional treatments following the protocol for ABO-incompatible transplants in other organs (multiple plasma exchanges and additional immunosuppressive therapy such as anti-thymocyte globulin administration). In Japan, major ABO-incompatible living-donor lobar lung transplantations have also been performed successfully when the recipient does not have an ABO antibody against the donor. This unique situation sometimes occurs when the recipient undergoes hematopoietic stem cell transplantation before lung transplantation, in which the recipient's blood type changes after hematopoietic stem cell transplantation. One infant and one adult had successful intentional major ABO-incompatible lung transplantation with both induction therapy and aggressive maintenance antibody-depletion therapy. Furthermore, an experimental antibody-depletion study has also been conducted to overcome ABO incompatibility. Even though intentional major ABO-incompatible lung transplantation has rarely been performed, several significant pieces of evidence have been accumulated to prepare for ABO-incompatible lung transplantation in selected cases. In the future, this challenge can potentially expand the donor organ pool and lead to improvements in the fairness of organ allocation.

DOI： 10.21037/jtd-23-48

Scopus

PubMed

Robotic resection of ectopic mediastinal parathyroid adenoma in multiple endocrine neoplasia 1. Reviewed International journal

Yuko Ohara, Yuka Kadomatsu, Toyone Kikumori, Toyofumi F Chen-Yoshikawa

Surgical case reports Vol. 9 ( 1 ) page： 114 - 114 2023.6

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Hyperparathyroidism in patients with multiple endocrine neoplasia 1 is attributed to the excessive secretion of parathyroid hormone (PTH) from multiple parathyroid glands. This can be successfully treated through complete resection of the parathyroid glands; however, subsequent surgery is often required because of the presence of supernumerary or ectopic parathyroid glands. Therefore, identifying the locations of all functional glands is crucial for precise resection. Here, we report a case of ectopic mediastinal parathyroid adenoma that was successfully resected using robot-assisted thoracoscopic surgery. CASE PRESENTATION: A 53-year-old woman underwent a total parathyroidectomy with autotransplantation for multiple endocrine neoplasia 1-associated primary hyperparathyroidism. The patient previously underwent laparoscopic distal pancreatectomy for a pancreatic neuroendocrine tumor. She also presented with a mediastinal tumor and nonfunctional pituitary adenoma that could be followed up. Blood tests before total parathyroidectomy showed high levels of intact PTH (183 pg/mL) and calcium (Ca; 10.3 mg/dL); however, postoperative blood tests still revealed high levels of intact PTH (103 pg/mL) and Ca (11.4 mg/dL). Computed tomography and magnetic resonance imaging revealed a 45-mm-sized mass in the right upper mediastinum as a well-defined solid and cystic lesion, whereas 99mTc-methoxyisobutylisonitrile scintigraphy indicated a strong accumulation of tracers, suggesting an ectopic lesion in the mediastinum. Persistent hyperparathyroidism after total parathyroidectomy via neck incision was attributed to an ectopic parathyroid tumor in the mediastinum. Thus, we decided to resect the tumor using robot-assisted thoracoscopic surgery to perform the procedure gently and carefully. During surgery, a mediastinal tumor was identified as it was detected radiographically. Because it did not invade the surrounding tissues, it could be completely resected without injuring the capsule. The patient was discharged without complications. Postoperatively, Ca and intact PTH levels decreased back to normal. The final pathological diagnosis confirmed that the mass was an ectopic mediastinal parathyroid adenoma. CONCLUSIONS: Minimally invasive surgical resection of a remnant ectopic lesion was successfully performed in a patient with multiple endocrine neoplasia 1 using robot-assisted thoracoscopic surgery.

DOI： 10.1186/s40792-023-01694-9

PubMed

シスプラチン投与困難な病理病期II-III期非小細胞肺癌症例の術後成績

則竹統, 中村彰太, 大原佑子, 岡戸翔嗣, 渡邉裕樹, 仲西慶太, 門松由佳, 上野陽史, 加藤毅人, 福本紘一, 芳川豊史

日本呼吸器外科学会雑誌 Vol. 37 ( 3 ) page： P4 - 6 2023.6

遷延する左気胸で発覚した悪性胸膜中皮腫の一例

岡戸翔嗣, 芳川豊史, 福本紘一, 中村彰太, 加藤毅人, 上野陽史, 門松由佳, 仲西慶太, 則竹統, 渡邉裕樹, 大原佑子

日本呼吸器外科学会雑誌 Vol. 37 ( 3 ) page： P78 - 6 2023.6

Development of panorama vision ring for thoracoscopy. Reviewed International journal

Takayuki Kitasaka, Shota Nakamura, Yuichiro Hayashi, Tsuyoshi Nakai, Yasuhiro Nakai, Kensaku Mori, Toyofumi Fengshi Chen-Yoshikawa

International journal of computer assisted radiology and surgery Vol. 18 ( 5 ) page： 945 - 952 2023.5

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Minimally invasive surgery (MIS) using a thoraco- or laparoscope is becoming a more common surgical technique. In MIS, a magnified view from a thoracoscope helps surgeons conduct precise operations. However, there is a risk of the visible area becoming narrow. To confirm that the operation field is safe, the surgeon will draw the thoracoscope back to check the marginal area of the target and insert it again many times during MIS. To reduce the surgeon's load, we aim to visualize the entire thoracic cavity using a newly developed device called "panorama vision ring" (PVR). METHOD: The PVR is used instead of a wound retractor or a trocar. It is a ring-type socket with one big hole for the thoracoscope and four small holes for tiny cameras placed around the big hole. The views from the tiny cameras are fused into one wider view that visualizes the entire thoracic cavity. A surgeon can proceed with an operation by checking what exists outside of the thoracoscopic view. Also, she/he can check whether or not bleeding has occurred from the image of the entire cavity. RESULTS: We evaluated the view-expansion ability of the PVR by using a three-dimensional full-scale thoracic model. The experimental results showed that the entire thoracic cavity could be visible in a panoramic view generated by the PVR. We also demonstrated pulmonary lobectomy in virtual MIS using the PVR. Surgeons could perform a pulmonary lobectomy while checking the entire cavity. CONCLUSION: We developed the PVR, which uses tiny auxiliary cameras to create a panoramic view of the entire thoracic cavity during MIS. We aim to make MIS safer for patients and more comfortable for surgeons through the development of the PVR.

DOI： 10.1007/s11548-023-02859-5

Scopus

PubMed

Clinical application of resection process map as a novel surgical guide in thoracic surgery. Reviewed International journal

Yuka Kadomatsu, Megumi Nakao, Harushi Ueno, Shota Nakamura, Koichi Fukumoto, Toyofumi Fengshi Chen-Yoshikawa

Interdisciplinary cardiovascular and thoracic surgery Vol. 36 ( 4 ) 2023.4

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

Resection Process Map (RPM) is a surgical simulation system that uses preoperative three-dimensional computed tomography. Unlike the usual static simulation, this system provides surgeons an individualized dynamic deformation of the lung parenchyma and vessels. RPM was first introduced in 2020. Although the intraoperative usefulness of this system has been evaluated experimentally, there have been no reports on its clinical use. Herein, we presented in detail the first experience on RPM during robot-assisted anatomical lung resection in the real clinical setting.

DOI： 10.1093/icvts/ivad059

PubMed

連載未来の専門医を育てる! 名古屋大学の呼吸器外科教育-理想と現実のはざまで考えること

芳川豊史

胸部外科 Vol. 76 ( 4 ) page： 313 - 315 2023.4

Video-assisted thoracoscopic surgery for pleuroperitoneal communication. Reviewed

Hideki Tsubouchi, Shota Nakamura, Takayuki Fukui, Yuka Kadomatsu, Harushi Ueno, Naoki Ozeki, Koichi Fukumoto, Masashi Mizuno, Toyofumi F Chen-Yoshikawa

Asian journal of endoscopic surgery Vol. 16 ( 2 ) page： 262 - 265 2023.4

Authorship：Last author,　Corresponding author Language：English

Here we report the cases of five patients on continuous ambulatory peritoneal dialysis (CAPD) who developed hydrothorax because of pleuroperitoneal communication. Preoperative computed tomography (CT) peritoneography revealed penetrated sites on the diaphragm in all patients. All patients underwent video-assisted thoracoscopic surgery (VATS), and a dialysate containing indigo carmine was injected intraperitoneally through a CAPD catheter to confirm the fistula. In all patients, a thinned bleb was found at the center of the diaphragmatic tendon consistent with that noted on preoperative CT peritoneography. The bleb was resected using a surgical stapler in four patients, and the pleuroperitoneal communication did not recur. However, in one patient, the bleb was only covered with reinforcement agents and the hydrothorax recurred after CAPD. This study demonstrates that VATS treatment for pleuroperitoneal communication is safe and effective but that lesion resection would be more useful for preventing hydrothorax recurrence in patients undergoing CAPD.

DOI： 10.1111/ases.13127

Scopus

PubMed

術前に加えて周術期における脊柱起立筋CT値の低下も予後不良因子である

大島洋平, 佐藤晋, 芳川豊史, 中島大輔, 栢分秀直, 田中里奈, 山田義人, 豊洋次郎, 濱路政嗣, 大角明宏, 伊達洋至, 松田秀一

移植 Vol. 57 ( 4 ) page： 335 - 335 2023.4

生体肺移植後の健康関連QoLの実態調査脳死肺移植との比較

大島洋平, 佐藤晋, 芳川豊史, 中島大輔, 吉岡佑二, 濱田涼太, 梶本泰志, 太田垣あゆみ, 田中里奈, 山田義人, 豊洋次郎, 大角明宏, 濱路政嗣, 伊達洋至, 松田秀一

移植 Vol. 57 ( 4 ) page： 425 - 425 2023.4

Enteral liquid ventilation oxygenates a hypoxic pig model Reviewed

Fujii T., Yoneyama Y., Kinebuchi A., Ozeki N., Maeda S., Saiki N., Chen-Yoshikawa T.F., Date H., Nishiwaki K., Takebe T.

iScience Vol. 26 ( 3 ) 2023.3

Language：English Publisher：iScience

The potential of extrapulmonary ventilation pathways remains largely unexplored. Here, we assessed the enteral ventilation approach in hypoxic porcine models under controlled mechanical ventilation. 20 mL/kg of oxygenated perfluorodecalin (O2-PFD) was intra-anally delivered by a rectal tube. We simultaneously monitored arterial and pulmonary arterial blood gases every 2 min up to 30 min to determine the gut-mediated systemic and venous oxygenation kinetics. Intrarectal O2-PFD administration significantly increased the partial pressure of oxygen in arterial blood from 54.5 ± 6.4 to 61.1 ± 6.2 mmHg (mean ± SD) and reduced the partial pressure of carbon dioxide from 38.0 ± 5.6 to 34.4 ± 5.9 mmHg. Early oxygen transfer dynamics inversely correlate with baseline oxygenation status. SvO2 dynamic monitoring data indicated that oxygenation likely originated from the venous outflow of the broad segment of large intestine including the inferior mesenteric vein route. Enteral ventilation pathway offers an effective means for systemic oxygenation, thus warranting further clinical development.

DOI： 10.1016/j.isci.2023.106142

Scopus

ASO Visual Abstract: Impact of Pleural Thickness on the Occurrence of Postoperative Complications in Patients with Malignant Pleural Mesothelioma

Ito T., Nakamura S., Kadomatsu Y., Ueno H., Kato T., Ozeki N., Fukumoto K., Chen-Yoshikawa T.F.

Annals of surgical oncology Vol. 30 ( 3 ) 2023.3

Impact of Pleural Thickness on Occurrence of Postoperative Complications in Patients with Malignant Pleural Mesothelioma Reviewed

Ito T., Nakamura S., Kadomatsu Y., Ueno H., Kato T., Ozeki N., Fukumoto K., Chen-Yoshikawa T.F.

Annals of Surgical Oncology Vol. 30 ( 3 ) page： 1574 - 1583 2023.3

Authorship：Last author Language：English Publisher：Annals of Surgical Oncology

Objectives: The rates of postoperative mortality and morbidity are high in patients with malignant pleural mesothelioma (MPM). Therefore, it is important to identify variables that increase the risk of postoperative complications. Pleural thickness has recently been identified as a prognostic indicator in patients with MPM. The aim of this study was to investigate clinical variables, including pleural thickness, that contribute to postoperative complications in patients with MPM. Patients and Methods: A total of 47 patients who underwent surgical excision of MPM between 2005 and 2021 were enrolled in this study. Correlations between postoperative complications within 90 days of surgery and preoperative clinical factors were investigated. Results: A total of 27 patients underwent extrapleural pneumonectomy (EPP), and the remaining 20 underwent pleurectomy/decortication (P/D). Macroscopic complete resections were obtained in all but three patients. Of the 47 patients, 23 (49%) experienced postoperative complications of grade 3 or worse. The major complication in patients with EPP was respiratory failure (n = 6), whereas the major complication in patients with P/D was prolonged air leakage (n = 7). Univariate logistic regression analysis found a correlation between postoperative complications and age, surgical side, and pleural thickness, while multivariate logistic regression analysis found surgical side (p = 0.04, 95% Cl 1.10–21.71, OR 4.90) and pleural thickness (p = 0.03, 95% Cl 1.21–23.00, OR 5.26) to significantly influence the occurrence of postoperative complications. Conclusions: Pleural thickness has a significant effect on the occurrence of postoperative complications. Patients with thick pleura on the right side are at greater risk of postoperative complications.

DOI： 10.1245/s10434-022-12790-9

Scopus

ASO Author Reflections: Pleural Thickness in Patients with Malignant Pleural Mesothelioma

Nakamura S., Ito T., Chen-Yoshikawa T.F.

Annals of Surgical Oncology Vol. 30 ( 3 ) page： 1584 - 1585 2023.3

Real-world evidence of safety and influence for lung cancer surgery under COVID-19 pandemic in Japan. Reviewed International journal

Taketo Kato, Ryotaro Katsuya, Shoji Okado, Keiyu Sato, Osamu Noritake, Keita Nakanishi, Misa Noguchi, Yuka Kadomatsu, Harushi Ueno, Naoki Ozeki, Shota Nakamura, Koichi Fukumoto, Toyofumi Fengshi Chen-Yoshikawa

Journal of thoracic disease Vol. 15 ( 2 ) page： 542 - 551 2023.2

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The COVID-19 pandemic has affected the clinical practice of lung cancer surgery in Japan, but few studies have revealed the real situation of surgical practice for lung cancer in this country. This latest information will help us to decide the future direction of lung cancer surgery under pandemic circumstances. METHODS: We collected data from patients with primary lung cancer who underwent thoracic surgery between 2018 and 2021. To investigate the impact of the COVID-19 pandemic on lung cancer surgery, we compared between 2018-2019 (prepandemic group) and 2020-2021 (pandemic group) in the respect of patient characteristics, pathological findings, and short-term outcome after lung cancer resection by Mann-Whitney and Fisher's exact tests. Moreover, the monthly number of surgeries for lung cancer in our institution during 2020-2021 was compared with the number of newly diagnosed COVID-19 patients in Japan by Spearman correlation analysis. RESULTS: From 2018 through 2021, 936 patients with primary lung cancer underwent surgical intervention in our institute and were included in this study. The number of surgeries did not decrease in the pandemic group (n=443) compared with that in the prepandemic group (n=493). Tumor and invasive size in stage I which was measured by pathologist were significantly larger in the pandemic group than in the prepandemic group (tumor size: P=0.031, invasive size: P<0.001). In terms of postoperative short-term outcome, the median hospital stay was 6 days, 30-day mortality was 2, and morbidity was around 20% in both groups. Only one patient suffered from COVID-19 infection 5 months after right upper lobectomy. An increased ratio of newly diagnosed COVID-19 cases in Japan was negatively correlated with the number of surgeries for lung cancer in our institution in the next month (r=-0.393, P=0.007), although there was no correlation in the present or the month after next. CONCLUSIONS: Even during the COVID-19 pandemic period, lung cancer surgery could be performed safely and in a sustainable manner. However, pathological findings of lung cancer tended to be progressive in early-stage lung cancer.

DOI： 10.21037/jtd-22-1289

Scopus

PubMed

The Clinical Application and Future Perspective of Fluorescence Imaging in the Treatment of Lung Cancer

Chen-Yoshikawa Toyofumi Fengshi

The Journal of Japan Society for Laser Surgery and Medicine Vol. 43 ( 4 ) page： 302 - 307 2023.1

Language：Japanese Publisher：Japan Society for Laser Surgery and Medicine

<p>As radiological imaging has progressed, smaller nodules are more frequently detected. The trend of minimal invasiveness in thoracic surgery has paved the way for video-assisted thoracic surgery. In localization for small nodules and segmentectomy for such nodules, fluorescent dyes, such as indocyanine green (ICG) have been used more often. Therefore, we herein describe the utility of fluorescent imaging in the treatment of lung cancer, which is currently the mainstream of thoracic surgery, focusing on the clinical application of ICG.</p>

DOI： 10.2530/jslsm.jslsm-43_0012

CiNii Research

Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis. Reviewed International journal

Hiroyuki Muranushi, Takero Shindo, Toyofumi F Chen-Yoshikawa, Akihiko Yoshizawa, Huong Thi Ngo, Fumiaki Gochi, Hiroshi Date, Akifumi Takaori-Kondo

Blood advances Vol. 7 ( 1 ) page： 106 - 121 2023.1

Language：English Publishing type：Research paper (scientific journal)

Patients with pulmonary graft-versus-host disease (pGVHD) have a poor prognosis after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, pGVHD pathogenesis is not fully elucidated in humans, and currently available immunosuppressants are inadequately effective. We performed pathologic evaluation of lung specimens from 45 allo-HSCT recipients with pGVHD who underwent lung transplantation. Patient pathology was characterized by bronchiolitis and subpleural perivascular inflammation, with B-cell, monocyte, and T-cell accumulation around bronchioles. Bronchiolitis, perivascular inflammation, and peribronchial macrophage aggregation were also identified in a murine pGVHD model after transplant of bone marrow cells and splenocytes from C57BL/6 to B10.BR mice. Among mitogen-activated protein kinase kinase (MEK) inhibitors, cobimetinib, but not trametinib, improved survival rates. Cobimetinib attenuated bronchiolitis, improved airway resistance and lung compliance in the mice, and suppressed activation of B cells and tumor necrosis factor α production by monocytes in vitro; these features were not suppressed by trametinib or tacrolimus. Furthermore, cobimetinib suppressed activation of phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling, resulting in B-cell and monocyte suppression. Dual inhibition of the MEK/extracellular signal-regulated kinase (ERK) and PI3K/AKT pathways using a combination of trametinib and the PI3K inhibitor taselisib strongly suppressed B-cell activation in vitro and improved mouse survival rates compared with vehicle or monotherapy with trametinib or taselisib. Imaging mass cytometry of human pGVHD revealed that T cells around bronchioles were positive for phosphorylated ERK, whereas B cells were positive for phosphorylated AKT. Thus, perivascular inflammation and bronchiolitis mediated by activation of the MEK/ERK and PI3K/AKT pathways are essential for pGVHD and represent a potential novel therapeutic target in humans.

DOI： 10.1182/bloodadvances.2021006678

PubMed

Cadaver surgical training for brain-dead donor lung procurement: Educational note Reviewed

Nakamura S., Ueno H., Mutsuga M., Chen-Yoshikawa T.F.

JTCVS Techniques 2023

Long-term outcomes following surgical treatment for thymic epithelial tumor in Japan and an analysis of prognostic factors based on the Japanese Association for Research on the Thymus nationwide database Reviewed

Okumura M., Yoshino I., Funaki S., Okuda K., Watanabe S.i., Tsuboi M., Shimizu K., Date H., Chen-Yoshikawa T.F., Nakajima J., Toyooka S., Asamura H.

Surgery Today 2023

Language：English Publisher：Surgery Today

Purpose: Patients with a thymic epithelial tumor (TET), comprising thymoma, thymic carcinoma (TC), and thymic neuroendocrine neoplasm (TNEN), are rarely encountered. The present study was conducted to determine the recent outcomes of surgical treatment for TET in Japan and clarify the significance of prognostic factors by analyzing a nationwide database created by the Japanese Association for Research on the Thymus (JART). Methods: The JART database includes records of 2471 thymoma, 285 TC, and 56 TNEN cases surgically treated between 1991 and 2010. At the time of the final follow-up examination, 439 patients had died, with tumor the cause of death in 188. The disease-specific survival was examined using the Kaplan–Meier method, with Cox’s proportional hazards model utilized to determine independent prognostic factors. Results: The 10-year survival rate according to TNM-based Stage I, II, IIIA, IIIB, IVA, and IVB classification was 98.7%, 76.8%, 85.0%, 68.9%, 66.2%, and 59.8%, respectively. The T factor, M factor, and tumor size were independent prognostic factors in both thymoma and thymic carcinoma cases, while the N factor had tendency to be a prognostic factor in thymoma but not in thymic carcinoma cases. The WHO histological type was an independent factor in thymoma cases. Conclusion: The significance of pathology and TNM classification as prognostic factors was confirmed.

DOI： 10.1007/s00595-023-02705-w

Scopus

Impact of perioperative airway pathogens on living-donor lobar lung transplantation outcomes Reviewed

Oda H., Tanaka S., Chen-Yoshikawa T.F., Morimura Y., Yamada Y., Yutaka Y., Nakajima D., Hamaji M., Ohsumi A., Menju T., Nagao M., Date H.

Surgery Today 2023

Language：English Publisher：Surgery Today

Purpose: To elucidate the clinical impact of pathogenic organism (PO) positivity early after transplantation, we evaluated the impact of perioperative airway POs on outcomes after living-donor lobar lung transplantation (LDLLT), where the graft airway is supposed to be sterile from a healthy donor. Method: A retrospective review of 67 adult LDLLT procedures involving 132 living donors was performed. Presence of POs in the recipients’ airways was evaluated preoperatively and postoperatively in intensive-care units. Results: POs were detected preoperatively in 13 (19.4%) recipients. No POs were isolated from the donor airways at transplantation. POs were detected in 39 (58.2%) recipients postoperatively; most were different from the POs isolated preoperatively. Postoperative PO isolation was not associated with short-term outcomes other than prolonged postoperative ventilation. The 5-year overall survival was significantly better in the PO-negative group than in the PO-positive group (89.1% vs. 63.7%, P = 0.014). In the multivariate analysis, advanced age (hazard ratio [HR]: 1.041 per 1-year increase, P = 0.033) and posttransplant PO positivity in the airway (HR: 3.684, P = 0.019) significantly affected the survival. Conclusions: The airways of the living-donor grafts were microbiologically sterile. PO positivity in the airway early after transplantation negatively impacted long-term outcomes.

DOI： 10.1007/s00595-023-02730-9

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Papers - CHEN-YOSHIKAWA Toyofumi