Faculty Profiles - CHEN-YOSHIKAWA Toyofumi

Papers - CHEN-YOSHIKAWA Toyofumi

Division display 241 - 260 of about 324 ／ All the affair displays >>

Primary peritoneal carcinoma with late-phase pulmonary metastases: a case report. International journal

Naoki Ozeki, Shuhei Hakiri, Hisashi Tateyama, Kohei Yokoi, Toyofumi Chen-Yoshikawa

Surgical case reports Vol. 5 ( 1 ) page： 194 - 194 2019.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Primary peritoneal carcinoma (PPC) is a very rare and aggressive type of malignancy with a poor prognosis. CASE PRESENTATION: A 66-year-old woman was referred to our hospital with two pulmonary nodules that developed after PPC resection and postoperative adjuvant chemotherapy administered 5 years earlier. Computed tomography revealed a 1.3-cm-sized nodule in the left lung with a small airspace in the posterior basal segment and a 0.9-cm-sized solid nodule in the apico-posterior segment that grew slightly within a 2-month period. 18F-Fluorodeoxyglucose-positron emission tomography of these lesions revealed respective maximum standardized uptake values of 7.11 and 2.46. Her serum cancer antigen-125 level remained within the normal range, despite elevation before the first surgery. The posterior basal segment and superior division were subjected to anatomical segmentectomy. An intraoperative frozen section examination could not distinguish metastatic PPC from primary lung cancer. Immunopathologically, the two nodules were identified as metastatic PPC. CONCLUSIONS: Our findings suggest that PPC patients may develop late-phase thoracic recurrence that is difficult to diagnose clinically after initial treatment in a potentially resectable setting.

DOI： 10.1186/s40792-019-0752-0

PubMed

Intermediate outcomes of right-to-left inverted living-donor lobar lung transplantation. International journal

Toyofumi F Chen-Yoshikawa, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Daisuke Nakajima, Akihiro Ohsumi, Masatsugu Hamaji, Toshi Menju, Hiroshi Date

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Vol. 56 ( 6 ) page： 1046 - 1053 2019.12

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: Owing to the severe donor shortage in Japan, living-donor lobar lung transplantation (LDLLT) remains a valuable option. As only lobes are implanted in LDLLT, grafts may be too small, especially for adult recipients. To overcome this obstacle, we developed right-to-left inverted LDLLT. In this procedure, the right lower lobe, which is 25% bigger than the left lower lobe, is used as the left-side graft instead of the left lower lobe. This study aimed to investigate the characteristics and intermediate outcomes of right-to-left inverted LDLLT. METHODS: Since the first right-to-left inverted LDLLT performed in 2014, 48 LDLLTs have been performed in our institution, of which 15 were right-to-left inverted LDLLTs. We reviewed their characteristics and intermediate outcomes. RESULTS: The reasons for choosing an inverted procedure instead of the standard LDLLT were small-for-size graft in 11 cases and anatomical variation of donor vessels in 4 cases. The first patient underwent left single LDLLT using a right lower lobe graft, and the following 14 patients underwent bilateral LDLLT using 2 right lower lobe grafts. A native upper lobe-sparing procedure was additionally applied in 2 patients. No complications occurred in the bronchial and vascular anastomoses. No operative mortality occurred, and all the patients were discharged home after LDLLT. The 3-year survival was 92.3%, with a median follow-up time of 40 months. The donor postoperative course was uneventful, and all the donors returned to their regular routine postoperatively. CONCLUSION: Right-to-left inverted LDLLT is a safe and useful option with encouraging intermediate outcome.

DOI： 10.1093/ejcts/ezz244

PubMed

Diameter of the dilated main pulmonary artery in patients with pulmonary hypertension decreases after lung transplantation.

Kayawake H, Aoyama A, Kinoshita H, Yoneda T, Baba S, Teramoto Y, Miyagawa-Hayashino A, Yamazaki K, Motoyama H, Hamaji M, Nakajima D, Chen-Yoshikawa TF, Date H

Surgery today Vol. 50 ( 3 ) page： 275 - 283 2019.10

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The pulmonary artery (PA) in patients with pulmonary hypertension (PH) becomes dilated. We analyzed the postoperative changes of the main PA after lung transplantation (LuTx). METHODS: The subjects of this retrospective study were 68 LuTx recipients, divided into a PH group (n = 36) and a non-PH group (n = 32), based on preoperative right heart catheterization findings. The PA diameter was measured on chest computed tomography. We evaluated the correlation between the mean pulmonary arterial pressure (mPAP) and the main PA diameter and compared the main PA diameters before and 3 months after LuTx. RESULTS: The main PA diameter was significantly correlated with the mPAP (r = 0.423, P < 0.001). Preoperatively, the mean main PA diameter in the PH group was significantly greater than that in the non-PH group. However, by 3 months after LuTx, the main PA diameter in the PH group had decreased significantly from 32.4 ± 6.7 to 26.9 ± 4.8 mm (P < 0.001), while that in the non-PH group had decreased minimally from 28.3 ± 4.9 to 26.4 ± 4.6 mm (P < 0.001), resulting in no significant difference in postoperative main PA diameters between the two groups. CONCLUSIONS: The main PA diameter in recipients with PH was enlarged and correlated with the mPAP. The dilated main PA diameter in PH patients decreased shortly after LuTx.

DOI： 10.1007/s00595-019-01887-6

PubMed

Resection Process Map: A novel dynamic simulation system for pulmonary resection.

Tokuno J, Chen-Yoshikawa TF, Nakao M, Matsuda T, Date H

The Journal of thoracic and cardiovascular surgery 2019.9

Emergent surgical treatment for acute thrombosis caused by pulmonary artery kinking after left upper sleeve lobectomy.

Nakajima D, Oda H, Chen-Yoshikawa TF, Date H

Interactive cardiovascular and thoracic surgery Vol. 29 ( 3 ) page： 481-483 2019.9

Completion pneumonectomy and auto-transplantation for bronchopleural fistula.

Hamaji M, Chen-Yoshikawa TF, Date H

The Journal of thoracic and cardiovascular surgery Vol. 158 ( 3 ) page： e121-e123 2019.9

Trametinib Attenuates Delayed Rejection and Preserves Thymic Function in Rat Lung Transplantation.

Takahagi A, Shindo T, Chen-Yoshikawa TF, Yoshizawa A, Gochi F, Miyamoto E, Saito M, Tanaka S, Motoyama H, Aoyama A, Takaori-Kondo A, Date H

American journal of respiratory cell and molecular biology Vol. 61 ( 3 ) page： 355-366 - 366 2019.9

臓器摘出合同シミュレーション実施6年間の総括アンケート結果を踏まえて Reviewed

古川博之, 福嶌教偉, 剣持敬, 松野直徒, 星川康, 江口晋, 伊藤泰平, 芳川豊史, 縄田寛, 山内治雄, 松田安史, 曽山明彦, 芦刈淳之介, 小野稔, 江川裕人

移植 Vol. 54 ( 総会臨時 ) page： 234 - 234 2019.9

Living-donor lobar lung transplants provide comparable pulmonary function to cadaveric lung transplants.

Nakajima D, Chen-Yoshikawa TF, Ohsumi A, Date H

The Journal of thoracic and cardiovascular surgery 2019.8

Use of a three-dimensional model in lung transplantation for a patient with giant pulmonary aneurysm. International journal

Oda H, Hamaji M, Motoyama H, Ikeda T, Minatoya K, Nakajima D, Chen-Yoshikawa TF, Date H

The Annals of thoracic surgery Vol. 109 ( 3 ) page： e183-e185 2019.8

Language：English Publishing type：Research paper (scientific journal)

Management of a giant pulmonary trunk aneurysm in lung transplantation is a challenge. Herein, we present a patient undergoing replacement of the giant pulmonary artery aneurysm with a donor's aorta in bilateral lung transplantation for idiopathic pulmonary arterial hypertension. A plastic three-dimensional model of the pulmonary artery aneurysm created accurately based on computed tomography data allowed us to simulate the procedure on the back table. Our intraoperative findings and management are discussed in this article.

DOI： 10.1016/j.athoracsur.2019.06.092

PubMed

Salvage surgery after chemo- or chemoradiotherapy for initially unresectable lung carcinoma.

Sonobe M, Yutaka Y, Nakajima D, Hamaji M, Menju T, Ohsumi A, Chen-Yoshikawa TF, Sato T, Date H

The Annals of thoracic surgery 2019.8

Surgery and stereotactic body radiotherapy for early stage non-small cell lung cancer: review of meta-analyses. Reviewed International journal

Masatsugu Hamaji, Yukinori Matsuo, Toyofumi Fengshi Chen-Yoshikawa, Takashi Mizowaki, Hiroshi Date

Journal of thoracic disease Vol. 11 ( Suppl 13 ) page： S1646-S1652 2019.8

Language：English Publishing type：Research paper (scientific journal)

Observational or randomized studies on survival outcome following surgery versus stereotactic body radiotherapy (SBRT) for early-stage non-small cell lung cancer (NSCLC) demonstrated various results, and several meta-analyses on this topic have been published. The PubMed database was queried for meta-analyses comparing surgery and SBRT for early stage NSCLC. Six meta-analyses on this comparison were identified and 4 (66.7%) suggested that surgery be associated with significantly more favorable overall survival than SBRT, using odds ratio or hazard ratio (HR) as measures of effect. Most of the included studies in the meta-analyses were observational studies and those meta-analyses should be interpreted with caution.

DOI： 10.21037/jtd.2018.10.35

PubMed

Acquired recipient pulmonary function is better than lost donor pulmonary function in living-donor lobar lung transplantation. International journal

Kayawake H, Chen-Yoshikawa TF, Hamaji M, Nakajima D, Ohsumi A, Aoyama A, Date H

The Journal of thoracic and cardiovascular surgery Vol. 158 ( 6 ) page： 1710 - 1716 2019.7

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: In standard bilateral living-donor lobar lung transplantation (LDLLT), the right and left lower lobes from 2 healthy donors are implanted in the recipient in place of whole right and left lungs. In other words, total 10 lobes (5 lobes in each donor) are shared by the 2 donors (4 lobes in each donor) and the recipient (2 lobes) in this transplant procedure. This study aimed to compare pulmonary function between donors and recipients before and after LDLLT. METHODS: We performed 76 LDLLT procedures between June 2008 and March 2017. After excluding 12 single LDLLT and 11 native-lung-sparing LDLLT procedures, we identified 38 recipients of bilateral LDLLT who survived >1 year and underwent routine pulmonary function testing. Acquired recipient pulmonary function was compared with lost donor pulmonary function at 1 year post-LDLLT. RESULTS: The median age of the 38 recipients was 44 years (range, 8-62 years); 14 were men. The median age of the 76 donors was 41.5 years (range, 20-60 years); 50 were men. One year post-LDLLT, acquired recipient forced vital capacity was significantly greater than lost donor forced vital capacity (1889.5 ± 581.3 mL vs 1073.9 ± 661.6 mL; P < .001). Similarly, acquired recipient forced expiratory volume in 1 second at 1 year post-LDLLT was significantly greater than lost donor forced expiratory volume in 1 second (1646.8 ± 483.0 mL vs 1064.2 ± 534.5 mL; P < .001). CONCLUSIONS: These results indicated that acquired recipient pulmonary function was better than lost donor pulmonary function in bilateral LDLLT.

DOI： 10.1016/j.jtcvs.2019.06.058

PubMed

In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids. International journal

Yohei Korogi, Shimpei Gotoh, Satoshi Ikeo, Yuki Yamamoto, Naoyuki Sone, Koji Tamai, Satoshi Konishi, Tadao Nagasaki, Hisako Matsumoto, Isao Ito, Toyofumi F Chen-Yoshikawa, Hiroshi Date, Masatoshi Hagiwara, Isao Asaka, Akitsu Hotta, Michiaki Mishima, Toyohiro Hirai

Stem cell reports Vol. 13 ( 1 ) page： 235 - 235 2019.7

Living-donor lung transplantation after surgical repair of transposition of the great arteries.

Yoshinaga D, Baba S, Hirata T, Fukushima H, Hamaji M, Aoyama A, Chen-Yoshikawa TF, Yamagishi H, Date H, Heike T

General thoracic and cardiovascular surgery Vol. 67 ( 7 ) page： 640-643 2019.7

Pirfenidone alleviates lung ischemia-reperfusion injury in a rat model.

Saito M, Chen-Yoshikawa TF, Suetsugu K, Okabe R, Takahagi A, Masuda S, Date H

The Journal of thoracic and cardiovascular surgery Vol. 158 ( 1 ) page： 289-296 2019.7

Surface deformation analysis of collapsed lungs using model-based shape matching.

Nakao M, Tokuno J, Chen-Yoshikawa T, Date H, Matsuda T

International journal of computer assisted radiology and surgery Vol. 14 ( 10 ) page： 1763 - 1774 2019.6

Nutrition-related factors associated with waiting list mortality in patients with interstitial lung disease: A retrospective cohort study. Reviewed International journal

Ayako Oshima, Akiko Nishimura, Toyofumi F Chen-Yoshikawa, Shin-Ichi Harashima, Teruya Komatsu, Tomohiro Handa, Akihiro Aoyama, Koji Takahashi, Masaki Ikeda, Yohei Oshima, Kohei Ikezoe, Susumu Sato, Maki Isomi, Kenichiro Shide, Hiroshi Date, Nobuya Inagaki

Clinical transplantation Vol. 33 ( 6 ) page： e13566 2019.6

Language：English

Japanese patients with interstitial lung disease (ILD) sometimes die waiting for lung transplantation (LTx) because it takes about 2 years to receive it in Japan. We evaluated nutrition-related factors associated with waiting list mortality. Seventy-six ILD patients were hospitalized in Kyoto University Hospital at registration for LTx from 2013 to 2015. Among them, 40 patients were included and analyzed. Patient background was as follows: female, 30%; age, 50.3 ± 6.9 years; body mass index, 21.1 ± 4.0 kg/m2 ; 6-minute walk distance (6MWD), 356 ± 172 m; serum albumin, 3.8 ± 0.4 g/dL; serum transthyretin (TTR), 25.3 ± 7.5 mg/dL; and C-reactive protein, 0.5 ± 0.5 mg/dL. Median observational period was 497 (range 97-1015) days, and median survival time was 550 (95% CI 414-686) days. Survival rate was 47.5%, and mortality rate was 38.7/100 person-years. Cox analyses showed that TTR (HR 0.791, 95% CI 0.633-0.988) and 6MWD (HR 0.795, 95% CI 0.674-0.938) were independently correlated with mortality and were influenced by body fat mass and leg skeletal muscle mass, respectively. It is suggested that nutritional markers and exercise capacity are important prognostic markers in waitlisted patients, but further study is needed to determine whether nutritional intervention or exercise can change outcomes.

DOI： 10.1111/ctr.13566

PubMed

Commentary: Promising future solution for unmet needs in lung transplantation.

Chen-Yoshikawa TF

The Journal of thoracic and cardiovascular surgery Vol. 157 ( 5 ) page： 2107-2108 2019.5

Ex Vivo Sleeve Lobectomy and Autotransplantation After Chemoradiation.

Yamashita T, Hamaji M, Nakanobo R, Aoyama A, Chen-Yoshikawa TF, Sonobe M, Date H

The Annals of thoracic surgery Vol. 107 ( 5 ) page： e341-e343 2019.5

　 PREV - NEXT 　

<CHEN-YOSHIKAWA Toyofumi>

Papers - CHEN-YOSHIKAWA Toyofumi