2024/01/15 更新

写真a

ナガシマ ヨシタカ
永島 吉孝
NAGASHIMA Yoshitaka
所属
医学部附属病院 脳神経外科 病院助教
職名
病院助教

学位 2

  1. 修士(医学) ( 2011年3月   福井大学 ) 

  2. 博士(医学) ( 2023年7月   名古屋大学 ) 

研究キーワード 8

  1. 脳神経外科学

  2. 脊椎脊髄疾患

  3. 遺伝子解析

  4. 神経再生

  5. 機械学習

  6. 脳神経外科学

  7. 慢性硬膜下血腫

  8. 脊髄損傷

研究分野 3

  1. ライフサイエンス / 腫瘍診断、治療学

  2. ライフサイエンス / 脳神経外科学

  3. ライフサイエンス / ゲノム生物学

所属学協会 7

  1. 日本脳神経外科学会

  2. 日本脳神経外科コングレス

  3. 日本脊髄外科学会

  4. 日本脊髄障害医学会

  5. 日本脳神経外傷学会

  6. AO Spine

  7. 日本脳卒中の外科学会

▼全件表示

委員歴 1

  1. 日本脊髄外科学会   代議員  

受賞 1

  1. 日本脳神経外傷学会 若手臨床研究支援プロジェクト

 

論文 48

  1. Protective Mechanism of Stem Cells from Human Exfoliated Deciduous Teeth in Treating Spinal Cord Injury.

    Nishii T, Osuka K, Nishimura Y, Ohmichi Y, Ohmichi M, Suzuki C, Nagashima Y, Oyama T, Abe T, Kato H, Saito R

    Journal of neurotrauma     2024年1月

     詳細を見る

    記述言語:英語  

    DOI: 10.1089/neu.2023.0251

    PubMed

  2. Efficacy of intraoperative irrigation with artificial cerebrospinal fluid in chronic subdural hematoma surgery: study protocol for a multicenter randomized controlled trial.

    Nagashima Y, Araki Y, Nishida K, Kuramitsu S, Wakabayashi K, Shimato S, Kinkori T, Nishizawa T, Kano T, Hasegawa T, Noda A, Maeda K, Yamamoto Y, Suzuki O, Koketsu N, Okada T, Iwasaki M, Nakabayashi K, Fujitani S, Maki H, Kuwatsuka Y, Nishihori M, Tanei T, Nishikawa T, Nishimura Y, Saito R, Tokai Neurosurgical disorder Research Group CSDH Study investigators

    Trials   25 巻 ( 1 ) 頁: 6   2024年1月

     詳細を見る

    記述言語:英語   出版者・発行元:Trials  

    Background: The surgical techniques for treatment of chronic subdural hematoma (CSDH), a common neurosurgical condition, have been discussed in a lot of clinical literature. However, the recurrence proportion after CSDH surgery remains high, ranging from 10 to 20%. The standard surgical procedure for CSDH involves a craniostomy to evacuate the hematoma, but irrigating the hematoma cavity during the procedure is debatable. The authors hypothesized that the choice of irrigation fluid might be a key factor affecting the outcomes of surgery. This multicenter randomized controlled trial aims to investigate whether intraoperative irrigation using artificial cerebrospinal fluid (ACF) followed by the placement of a subdural drain would yield superior results compared to the placement of a subdural drain alone for CSDH. Methods: The study will be conducted across 19 neurosurgical departments in Japan. The 1186 eligible patients will be randomly allocated to two groups: irrigation using ACF or not. In either group, a subdural drain is to be placed for at least 12 h postoperatively. Similar to what was done in previous studies, we set the proportion of patients that meet the criteria for ipsilateral reoperation at 7% in the irrigation group and 12% in the non-irrigation group. The primary endpoint is the proportion of patients who meet the criteria for ipsilateral reoperation within 6 months of surgery (clinical worsening of symptoms and increased hematoma on imaging compared with the postoperative state). The secondary endpoints are the proportion of reoperations within 6 months, the proportion being stratified by preoperative hematoma architecture by computed tomography (CT) scan, neurological symptoms, patient condition, mortality at 6 months, complications associated with surgery, length of hospital stay from surgery to discharge, and time of the surgical procedure. Discussion: We present the study protocol for a multicenter randomized controlled trial to investigate our hypothesis that intraoperative irrigation with ACF reduces the recurrence proportion after the removal of chronic subdural hematomas compared with no irrigation. Trial registration: ClinicalTrials.gov jRCT1041220124. Registered on January 13, 2023.

    DOI: 10.1186/s13063-023-07889-7

    Scopus

    PubMed

  3. Lateral Lumbar Interbody Fusion within Three-level for Patients with Neurological Symptoms due to Vertebral Fragility Fractures in the Lumbar Spine.

    Nagashima Y, Nishimura Y, Kanemura T, Hata N, Satake K, Akahori S, Ishii M, Tanei T, Takayasu M, Saito R

    Neurologia medico-chirurgica   advpub 巻 ( 0 )   2023年10月

     詳細を見る

    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/jns-nmc.2023-0064

    PubMed

    CiNii Research

  4. Development of machine learning models for predicting unfavorable functional outcomes from preoperative data in patients with chronic subdural hematomas.

    Fuse Y, Nagashima Y, Nishiwaki H, Ohka F, Muramatsu Y, Araki Y, Nishimura Y, Ienaga J, Nagatani T, Seki Y, Watanabe K, Ohno K, Saito R

    Scientific reports   13 巻 ( 1 ) 頁: 16997   2023年10月

     詳細を見る

    記述言語:英語  

    DOI: 10.1038/s41598-023-44029-2

    PubMed

  5. Efficacy of the latest new stimulation patterns of spinal cord stimulation for intractable neuropathic pain compared to conventional stimulation: study protocol for a clinical trial. 国際誌

    Tanei T, Maesawa S, Nishimura Y, Nagashima Y, Ishizaki T, Ando M, Kuwatsuka Y, Hashizume A, Kurasawa S, Saito R

    Trials   24 巻 ( 1 ) 頁: 604 - 604   2023年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Trials  

    Background: Spinal cord stimulation (SCS) is one of the neuromodulation therapies for chronic neuropathic pain. The conventional paresthesia-based SCS involves the application of tonic stimulation that induces a sense of paresthesia. Recently, new SCS stimulation patterns without paresthesia have been developed. Differential target multiplexed (DTM) stimulation and fast-acting subperception therapy (FAST) stimulation are the latest paresthesia-free SCS patterns. Methods: A single-center, open-label, crossover, randomized clinical trial to investigate the superiority of SCS using the latest new stimulation patterns over conventional tonic stimulation for neuropathic pain is planned. This study consists of two steps: SCS trial (first step) and SCS system implantation (second step). In the SCS trial, participants will be randomly assigned to 4 groups receiving stimulation, including tonic, DTM, and FAST. Each stimulation will then be performed for 2 days, and a visual analog scale (VAS) for pain will be evaluated before and after each stimulation pattern. A stimulation-off period for 1 day is set between each stimulation pattern to wash out the residual previous stimulation effects. Pain improvement is defined as more than 33% reduction in the pain VAS. The primary analysis will compare pain improvement between the new stimulation patterns and the conventional tonic stimulation pattern in the SCS trial. The secondary outcomes will be evaluated as follows: (1) the relationships between causative disease and improvement rate by each stimulation pattern; (2) comparison of pain improvement between the DTM and FAST stimulation patterns in all cases and by causative disease; (3) changes in assessment items preoperatively to 24 months after the implantation; (4) preoperative factors associated with long-term effects defined as continuing for more than 12 months; and (5) adverse events related to this study 3 months after the implantation. Discussion: This study aims to clarify the effectiveness of the latest new stimulation patterns compared to the conventional tonic stimulation. In addition, which stimulation pattern is most effective for which kind of causative disease will be clarified. Trial registration: Japan Registry of Clinical Trials (jRCT) 1,042,220,094. Registered on 21 November 2022, and last modified on 6 January 2023. jRCT is an approved member of the Primary Registry Network of WHO ICTRP.

    DOI: 10.1186/s13063-023-07637-x

    Scopus

    PubMed

  6. Comparative Study of Surgical Outcomes of Occipitocervical and Atlantoaxial Fusion for Retro-Odontoid Pseudotumor.

    Nishii T, Nishimura Y, Nagashima Y, Tanei T, Hara M, Takayasu M, Kanemura T, Saito R

    World neurosurgery     2023年7月

     詳細を見る

    記述言語:英語  

    DOI: 10.1016/j.wneu.2023.07.038

    PubMed

  7. Direct Screw Osteosynthesis for an Elderly Osteoporotic Patient With C2 Complex Fracture.

    Nagashima Y, Nishimura Y, Matsuo M, Tanei T, Saito R

    Cureus   15 巻 ( 7 ) 頁: e42510   2023年7月

     詳細を見る

  8. Differential target multiplexed spinal cord stimulation using a paddle-type lead placed at the appropriate site for neuropathic pain after spinal cord injury in patients with past spinal surgical histories: study protocol for an exploratory clinical trial.

    Tanei T, Maesawa S, Nishimura Y, Nagashima Y, Ishizaki T, Ando M, Kuwatsuka Y, Hashizume A, Kurasawa S, Saito R

    Trials   24 巻 ( 1 ) 頁: 395   2023年6月

     詳細を見る

    記述言語:英語  

    DOI: 10.1186/s13063-023-07433-7

    PubMed

  9. Surgical Outcomes of Common Peroneal Nerve Entrapment Neuropathy Associated with L5 Radiculopathy.

    Ishii M, Nishimura Y, Hara M, Yamamoto Y, Nagashima Y, Tanei T, Takayasu M, Saito R

    Neurologia medico-chirurgica   advpub 巻 ( 0 )   2023年6月

     詳細を見る

    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/jns-nmc.2022-0313

    PubMed

    CiNii Research

  10. 造骨性脊椎転移が発生に関与したと考えられる椎間板ヘルニア

    西井智哉, 灰本章一, 永島吉孝, 石井元規, 深谷宜央

    日本脊髄障害医学会誌   36 巻 ( 1 ) 頁: 14 - 15   2023年6月

  11. Radiographic Prediction of the Occipito-C2 Angle Variation with Changes in Distance between the Mandible and Cervical Vertebrae: A Preliminary Study.

    Nagashima Y, Nishimura Y, Awaya T, Hata N, Tanei T, Ishii M, Oyama T, Nishii T, Fukaya N, Abe T, Kato H, Saito R

    Neurologia medico-chirurgica   63 巻 ( 5 ) 頁: 200 - 205   2023年5月

     詳細を見る

    記述言語:英語   出版者・発行元:Neurologia Medico-Chirurgica  

    The Occipito(O)-C2 angle reflects the correct craniocervical spine alignment; however, the poor image quality of standard intraoperative fluoroscopy at times lead to inaccurate measurements. Herein, we preliminarily investigated the relationship between the O-C2 angle and the Gonion-C2 distance, which is based on the positioning of the mandible and the cervical spine. We enrolled patients who underwent cervical spine radiography in neutral, flexion, and extension positions from January 2020 to Oc-tober 2020. The difference by posture changes for each parameter was defined as the Δ value, and the Spearman’s rank correlation coefficient was determined. Furthermore, we determined the cutoff value of the ΔGonion-C2 distance to predict a decrease of > 10° in the ΔO-C2 angle, which is reported to be related to dysphagia and dyspnea. Seventy-four patients were included. Spearman’s rank correlations for the neutral, flexion, and extension positions were 0.630 (P < 0.001), 0.471 (P < 0.001), and 0.625 (P < 0.001), respectively, while the cutoff values of the ΔGonion-C2 distance for predicting > 10° in the ΔO-C2 angle were 9.3 mm for the neutral flexion change (sensitivity: 0.435, specificity: 0.882) and 8.3 mm for the extension-neutral change (sensitivity: 0.712, specificity: 0.909). The O-C2 angle and Gonion-C2 distances correlated; however, this correlation was weaker in the flexed position. Nevertheless, the ΔGonion-C2 distance can be used as a warning sign for postoperative complications after posterior oc-cipital bone fusion surgery, because a decrease of > 10° in the ΔO-C2 angle can be predicted with high specificity.

    DOI: 10.2176/jns-nmc.2022-0251

    Web of Science

    Scopus

    PubMed

    CiNii Research

  12. Butterfly needle tap and suction (BTS) technique: a treatment for recurrent chronic subdural hematoma after burr hole craniostomy. 査読有り 国際誌

    Yamamoto S, Nagashima Y, Maki H, Nishimura Y, Araki Y, Nishihori M, Noda T, Imai T, Kawabata T, Ueno M, Nishida Y, Saito R

    Acta neurochirurgica     2023年3月

     詳細を見る

    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00701-023-05543-4

    PubMed

  13. Evaluation of Posterior Ligamentous Complex Injury in Thoracolumbar Burst Fractures: Correlation Analysis of CT and MRI Findings. 査読有り

    Yoshikawa S, Nishimura Y, Nagashima Y, Ito H, Oyama T, Nishii T, Gonda T, Ryu H, Nomura K, Hara M, Takayasu M, Ginsberg HJ, Kanemura T, Saito R

    Neurologia medico-chirurgica     2023年3月

     詳細を見る

    記述言語:英語  

    DOI: 10.2176/jns-nmc.2021-0390

    PubMed

  14. Pineal parenchymal tumor of intermediate differentiation with late spinal dissemination 13 years after initial surgery: illustrative case. 査読有り 国際誌

    Hiroyuki Kato, Takafumi Tanei, Yusuke Nishimura, Yoshitaka Nagashima, Motonori Ishii, Tomoya Nishii, Nobuhisa Fukaya, Takashi Abe, Ryuta Saito

    Journal of neurosurgery. Case lessons   5 巻 ( 7 )   2023年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Pineal parenchymal tumors of intermediate differentiation (PPTIDs) are rare in the pineal gland. A case of PPTID that disseminated to the lumbosacral spine 13 years after the total resection of a primary intracranial tumor has been reported. OBSERVATIONS: A 14-year-old female presented with headache and diplopia. Magnetic resonance imaging revealed a pineal tumor that induced obstructive hydrocephalus. A biopsy and endoscopic third ventriculostomy were performed. Histological diagnosis revealed a grade II PPTID. Two months later, the tumor was removed via craniotomy because the postoperative Gamma Knife surgery was ineffective. Histological diagnosis confirmed PPTID, although the grade was revised from II to III. Postoperative adjuvant therapy was not performed, because the lesion had been irradiated and gross total tumor removal was achieved. She has had no recurrence in 13 years. However, pain around the anus newly appeared. Magnetic resonance imaging of the spine revealed a solid lesion in the lumbosacral spine. The lesion was subtotally resected, and histological diagnosis revealed grade III PPTID. Postoperative radiotherapy was performed, and she had no recurrence 1 year after radiotherapy. LESSONS: Remote dissemination of PPTID can occur several years after the initial resection. Regular follow-up imaging, including the spinal region, should be encouraged.

    DOI: 10.3171/CASE22475

    PubMed

  15. Relief of Central Poststroke Pain Affecting Both the Arm and Leg on One Side by Double-independent Dual-lead Spinal Cord Stimulation Using Fast-acting Subperception Therapy Stimulation: A Case Report 査読有り

    TANEI Takafumi, MAESAWA Satoshi, NISHIMURA Yusuke, NAGASHIMA Yoshitaka, ISHIZAKI Tomotaka, MUTOH Manabu, ITO Yoshiki, SAITO Ryuta

    NMC Case Report Journal   10 巻 ( 0 ) 頁: 15 - 20   2023年2月

     詳細を見る

    記述言語:英語   出版者・発行元:The Japan Neurosurgical Society  

    <p>Central poststroke pain is a chronic, intractable, central neuropathic pain. Spinal cord stimulation is a neuromodulation therapy for chronic neuropathic pain. The conventional stimulation method induces a sense of paresthesia. Fast-acting subperception therapy is one of the latest new stimulation methods without paresthesia. A case of achieving pain relief of central poststroke pain affecting both the arm and leg on one side by double-independent dual-lead spinal cord stimulation using fast-acting subperception therapy stimulation is presented. A 67-year-old woman had central poststroke pain due to a right thalamic hemorrhage. The numerical rating scale scores of the left arm and leg were 6 and 7, respectively. Using dual-lead stimulation at the Th 9-11 levels, a spinal cord stimulation trial was performed. Fast-acting subperception therapy stimulation achieved pain reduction in the left leg from 7 to 3. Therefore, a pulse generator was implanted, and the pain relief continued for 6 months. Then, two additional leads were implanted at the C 3-5 levels, and pain in the arm decreased from 6 to 4. Independent setting and adjustments of the dual-lead stimulation were required because the thresholds of paresthesia perception were significantly different. To achieve pain relief in both the arm and leg, double-independent dual-lead stimulation placed at cervical and thoracic levels is an effective treatment. Fast-acting subperception therapy stimulation may be effective for central poststroke pain, especially in cases where the paresthesia is perceived as uncomfortable or the conventional stimulation itself is ineffective.</p>

    DOI: 10.2176/jns-nmc.2022-0336

    CiNii Research

  16. The usefulness of three-dimensional fusion imaging of spinal arteriovenous malformation by a workstation connected to angiography systems. 査読有り

    Nagashima Y, Izumi T, Nishimura Y, Nishihori M, Oyama T, Matsuo M, Ito H, Nishii T, Saito R

    Nagoya journal of medical science   85 巻 ( 1 ) 頁: 127 - 133   2023年2月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.18999/nagjms.85.1.127

    PubMed

  17. Surgical and Endovascular Treatments for Asymptomatic Arteriovenous Fistulas at the Craniocervical Junction: A Multicenter Study

    Inoue T., Endo T., Takai K., Seki T., Ito K., Iwasaki M., Uchikado H., Umebayashi D., Otsuka M., Ohtonari T., Oda J., Kageyama H., Kurokawa R., Koyanagi I., Koizumi S., Sugawara T., Takeshima Y., Nagashima Y., Nishikawa M., Fujimoto M., Honda F., Matsui S., Matsumoto Y., Mitsuhara T., Miyoshi Y., Murata H., Yasuhara T., Yamahata H., Yamamoto S.

    World Neurosurgery     2023年

     詳細を見る

    出版者・発行元:World Neurosurgery  

    Objective: Asymptomatic craniocervical junction arteriovenous fistulas (CCJ AVFs) are rare and, thus, a consensus has not yet been reached regarding the indication of surgical interventions. This retrospective multicenter cohort study investigated the risks associated with surgery for asymptomatic CCJ AVFs and discussed the indication of surgical interventions. Methods: Using data from 111 consecutive patients with CCJ AVFs registered with the Neurospinal Society of Japan between 2009 and 2019, we analyzed the treatment, complications, and outcomes of 18 patients with asymptomatic CCJ AVF. Results: The median age of the patient cohort was 68 years (37–80 years), and there were 11 males and 7 females. Diagnoses were 14 patients with dural AVF, one perimedullary AVF, one radicular AVF, one epidural AVF, and one bilateral dural and epidural AVF. Initial treatment included direct surgery in 12 patients, endovascular treatment in four, and conservative treatment in two. Among 16 patients, three complications (18.7%) occurred: spinal cord infarction associated with the surgical procedure, cerebral infarction associated with intraoperative angiography, and mortal medullary hemorrhage after endovascular treatment followed by open surgery. Complete occlusion was achieved in all 12 patients in the direct surgery group and in one out of four in the endovascular treatment group. Conclusions: Given the risk of serious complications associated with asymptomatic CCJ AVF and the fact that no case of asymptomatic CCJ AVF became symptomatic in this study, prophylactic surgery for asymptomatic CCJ AVF should be carefully considered.

    DOI: 10.1016/j.wneu.2023.04.068

    Scopus

  18. Efficacy of Spinal Cord Stimulation Using Differential Target Multiplexed Stimulation for Intractable Pain of Hereditary Neuropathy with Liability to Pressure Palsies: A Case Report.

    Tanei T, Nishimura Y, Nagashima Y, Ishii M, Nishii T, Fukaya N, Abe T, Kato H, Maesawa S, Saito R

    NMC case report journal   10 巻 ( 0 ) 頁: 203 - 208   2023年

     詳細を見る

    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    DOI: 10.2176/jns-nmc.2023-0023

    PubMed

    CiNii Research

  19. Sacral arteriovenous fistula with lower thoracic cord edema without perimedullary vein enlargement.

    Ishii M, Nishimura Y, Nagashima Y, Tanei T, Nishihori M, Izumi T, Saito R

    Surgical neurology international   14 巻   頁: 295   2023年

     詳細を見る

    記述言語:英語  

    DOI: 10.25259/SNI_606_2023

    PubMed

  20. Widespread spontaneous spinal epidural hematoma treated with a combined technique using a flexible neuroendoscope after hemilaminectomy: A case report.

    Choo J, Maeda K, Takemoto M, Sakamoto Y, Nagashima Y

    Surgical neurology international   14 巻   頁: 361   2023年

     詳細を見る

    記述言語:英語   出版者・発行元:Surgical Neurology International  

    Background: One-third of spinal epidural hematomas occur spontaneously, and these may be associated with the acute onset of severe paralysis. Here, we present a case of T4-L4 symptomatic spontaneous spinal epidural hematoma which was successfully removed using a flexible neuroendoscope after hemilaminectomy. Case Description: Using flexible neuroendoscopy, we successfully treated a T4-L4 spinal epidural hematoma in an 89-year-old Japanese female who spontaneously developed back pain and paraparesis. The hematoma was removed utilizing a hemilaminectomy at three vertebral levels (T11, T12, and L1), while the remaining hematoma debris was completely evacuated with flexible neuroendoscopy. Neurological improvement was observed immediately postsurgery. Conclusion: Flexible neuroendoscopy provided a less extensive surgical method for removing a T4-L4 spontaneous epidural hematoma.

    DOI: 10.25259/SNI_749_2023

    Scopus

    PubMed

  21. Spinal Cord Stimulation for Neuropathic Pain following a Spinal Cord Lesion with Past Spinal Surgical Histories Using a Paddle Lead Placed on the Rostral Side of the Lesion: Report of Three Cases 査読有り

    FUKAYA Nobuhisa, TANEI Takafumi, NISHIMURA Yusuke, HARA Masahito, HATA Nobuhiro, NAGASHIMA Yoshitaka, MAESAWA Satoshi, ARAKI Yoshio, SAITO Ryuta

    NMC Case Report Journal   9 巻 ( 0 ) 頁: 349 - 355   2022年12月

     詳細を見る

    記述言語:英語   出版者・発行元:The Japan Neurosurgical Society  

    <p>Spinal cord parenchymal lesions may induce intractable neuropathic pain. However, the efficacy of conventional spinal cord stimulation for the neuropathic pain following spinal cord lesions remains to be controversial. In this study, we present three cases of spinal cord stimulation using a paddle lead at the rostral side of the spinal lesion causing pain symptoms. Good pain reductions were achieved using conventional stimulation in one case and using differential target multiplexed stimulation in two cases. Case 1: A 55-year-old man presented with neuropathic pain affecting his bilateral upper extremities due to a traumatic cervical spinal cord injury. Conventional stimulation via a paddle-type electrode was able to reduce the pain from 8 to 4 via a visual analog scale. Case 2: A 67-year-old man had undergone three spinal surgeries. He presented with pain and numbness of bilateral lower extremities due to a spinal cord lesion by thoracic disc herniation. Differential target multiplexed stimulation via a paddle-type electrode achieved excellent pain reduction, that is, from 9 to 2 on the visual analog scale. Case 3: An 80-year-old man presented with pain in his bilateral upper extremities due to a cervical spinal cord lesion caused by compression and spinal canal stenosis. Posterior cervical decompression and paddle-type electrode placement were performed simultaneously. Differential target multiplexed stimulation was able to achieve excellent pain reduction, from 7 to 2 on the visual analog scale. Spinal cord stimulation using a paddle lead at the rostral side of the spinal lesion and differential target multiplexed stimulation may provide significant opportunities for patients with intractable neuropathic pain following spinal cord lesions.</p>

    DOI: 10.2176/jns-nmc.2022-0218

    CiNii Research

  22. Diagnosis and Treatment Strategies for Arachnoiditis Ossificans Following Subarachnoid Hemorrhage: A Case Report 査読有り

    NAGASHIMA Yoshitaka, NISHIMURA Yusuke, ITO Hiroshi, NISHII Tomoya, OYAMA Takahiro, SAITO Ryuta

    NMC Case Report Journal   9 巻 ( 0 ) 頁: 295 - 299   2022年12月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   出版者・発行元:The Japan Neurosurgical Society  

    <p>Arachnoiditis ossificans (AO) is a rare disease, wherein ossified lesions in the subarachnoid space obstruct the flow of spinal fluid or compress the spinal cord, thereby causing myelopathy. Here we describe a rare case of AO and discuss the diagnosis and treatment strategies for this disease. A 66-year-old man with a history of subarachnoid hemorrhage presented with gait disturbance and dysuria for 7 months. Spinal magnetic resonance imaging and computed tomography (CT) myelography showed syringomyelia at the T5-T8 level and dorsally tethered spinal cord at the T8-T10 level. Preoperative noncontrast CT was not performed. The patient was diagnosed with adhesive arachnoiditis and underwent arachnoidolysis. However, intraoperative findings showed the presence of ossification lesions on the dorsal surface of the spinal cord, and intraoperative ultrasound (IOU) showed a hyperintense lesion with acoustic shadowing on the dorsal surface of the spinal cord, with limited visibility of the spinal cord. After removal of the lesions, IOU showed untethered and well-decompressed spinal cord and restoration of cerebrospinal fluid pulsation. Based on these findings, the patient was finally diagnosed with AO, which is an extremely rare disease, with an unknown frequency of occurrence. Therefore, all patients with adhesive spinal arachnoiditis require a preoperative noncontrast CT scan to evaluate for ossification lesions. In this case, we were fortunate to be able to treat AO with IOU, which demonstrated specific findings.</p>

    DOI: 10.2176/jns-nmc.2022-0036

    CiNii Research

  23. Comparative Study of Anterior Transvertebral Foraminotomy and Anterior Cervical Discectomy and Fusion for Unilateral Cervical Spondylotic Radiculopathy. 査読有り

    Akahori S, Nishimura Y, Eguchi K, Nagashima Y, Ando R, Awaya T, Tanei T, Hara M, Kanemura T, Takayasu M, Saito R

    World neurosurgery     2022年12月

     詳細を見る

    記述言語:英語  

    DOI: 10.1016/j.wneu.2022.12.053

    PubMed

  24. 脊椎脊髄疾患における3Dプリンター活用の実際と現状 査読有り

    永島吉孝 他

    脊髄外科     2022年12月

     詳細を見る

    担当区分:筆頭著者   記述言語:日本語   掲載種別:研究論文(学術雑誌)  

  25. Magnetic resonance imaging scans of cervical spinal cord ependymoma with changing radiological features over a short period of time. 査読有り

    Nagashima Y, Nishimura Y, Saito R

    World neurosurgery     2022年8月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.1016/j.wneu.2022.08.116

    PubMed

  26. Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors. 査読有り

    Nagashima Y, Nishimura Y, Eguchi K, Yamaguchi J, Haimoto S, Ohka F, Takayasu M, Saito R

    Neurospine     2022年5月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語  

    DOI: 10.14245/ns.2244168.084

    PubMed

  27. Radiological analysis of minimally invasive microscopic laminectomy for lumbar canal stenosis with a focus on multilevel stenosis and spondylolisthesis. 査読有り

    Awaya T, Nishimura Y, Eguchi K, Nagashima Y, Ando R, Akahori S, Yoshikawa S, Haimoto S, Hara M, Takayasu M, Saito R

    World neurosurgery     2022年4月

     詳細を見る

    記述言語:英語  

    DOI: 10.1016/j.wneu.2022.04.079

    PubMed

  28. Laminectomy triggers symptomatic growth of spinal schwannoma in a patient with schwannomatosis. 査読有り 国際誌

    Oyama T, Nishimura Y, Nagashima Y, Nishii T, Hara M, Takayasu M, Sakakibara A, Saito R

    Surgical neurology international   13 巻   頁: 261 - 261   2022年

     詳細を見る

    記述言語:英語  

    DOI: 10.25259/SNI_453_2022

    PubMed

  29. The preoperative focal cerebral blood flow status may be associated with slow flow in the bypass graft after combined surgery for moyamoya disease. 査読有り

    Araki Y, Yokoyama K, Uda K, Kanamori F, Mamiya T, Takayanagi K, Ishii K, Shintai K, Nishihori M, Tsukada T, Takeuchi K, Tanahashi K, Nagata Y, Nishimura Y, Tanei T, Nagashima Y, Muraoka S, Izumi T, Seki Y, Saito R

    Surgical neurology international   13 巻   頁: 511   2022年

     詳細を見る

    記述言語:英語   出版者・発行元:Surgical Neurology International  

    Background: The aim of this study was to investigate the association between early postoperative slow flow in bypass grafts and preoperative focal cerebral blood flow (CBF) in patients who underwent combined surgery for moyamoya disease (MMD). Methods: The subjects were 18 patients (22 surgeries) who underwent single photon emission computed tomography (SPECT) before surgery. The CBF value of the middle cerebral artery territory was extracted from the SPECT data, and the value relative to the ipsilateral cerebellar CBF (relative CBF, or RCBF) was calculated. The association between RCBF and early postoperative slow flow in the bypass graft was investigated. In addition, the correlation between the revascularization effect and preoperative RCBF was analyzed. Results: In four of 22 surgeries (18.2%), slow flow in the bypass graft was identified in the early postoperative period. Preoperative RCBF in the slow flow and patent groups was 0.86 ± 0.15 and 0.87 ± 0.15, respectively, with no significant difference (P = 0.72). The signal intensity of four slow-flowed bypasses was improved in all cases on magnetic resonance angiography images captured during the chronic phase (mean of 3.3 months postoperatively). The revascularization scores were 2 ± 0.82 and 2.1 ± 0.68 in the slow flow and patent groups, respectively, and did not differ significantly (P = 0.78). A significant correlation was not observed between preoperative RCBF and the revascularization effect. Conclusion: No significant association was observed between preoperative RCBF and early postoperative slow flow in bypass grafts in patients with MMD undergoing combined surgery. Given the high rate of improved depiction of slow-flowed bypass in the chronic postoperative phase, the conceptual significance of an opportune surgical intervention is to maintain CBF by supporting the patient's own intracranial-extracranial conversion function.

    DOI: 10.25259/SNI_772_2022

    Scopus

    PubMed

  30. Unilateral laminotomy for bilateral decompression and balloon kyphoplasty to decompress lumber canal stenosis aggravated by osteoporotic vertebral compression fractures: A technical note. 査読有り

    Nagashima Y, Nishimura Y, Ishii M, Nishii T, Fukaya N, Oyama T, Abe T, Kato H, Tsukamoto E, Tanei T, Saito R

    Surgical neurology international   13 巻   頁: 538   2022年

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   出版者・発行元:Surgical Neurology International  

    Background: The optimal treatment of lumbar canal stenosis (LCS) associated with osteoporotic vertebral fractures (OVFs) remains unclear. Here, we have combined a minimally invasive unilateral laminotomy for bilateral decompression (ULBD) alone with balloon kyphoplasty (BKP) for LCS aggravated by OVF. Methods: ULBD with BKP was performed in three patients who showed LCS associated with OVFs on MR images with progressive lower extremity neurological deficits. Clinical outcomes were assessed using the numerical rating scale (NRS) and the Japanese Orthopaedic Association (JOA) score. Radiological outcomes were evaluated using multiple parameters (i.e., fractured vertebral body height, lumbar lordosis [LL], and focal angle of the fractured vertebral body). Results: Over 6 postoperative months, the NRS and JOA scores were clearly improved while radiological parameters remained maintained (i.e., loss of fractured vertebral body height was only 0.3-1.4 mm in all cases). Two of the three cases showed restoration of LL and focal angle postoperatively. Conclusion: The combination of ULBD with BKP is an effective option for LCS aggravated by OVF.

    DOI: 10.25259/SNI_971_2022

    Scopus

    PubMed

  31. Atypical radiographic case of arachnoid web without scalpel sign. 査読有り

    Nagashima Y, Nishimura Y, Ito H, Oyama T, Nishii T, Gonda T, Kato H, Saito R

    Surgical neurology international   13 巻   頁: 108   2022年

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   出版者・発行元:Surgical Neurology International  

    Background: Spinal arachnoid webs (SAW) occur when abnormally thickened bands of arachnoid membranes commonly located dorsal to the thoracic spine cause blockage of normal cerebrospinal fluid (CSF) flow, resulting in focal cord compression and myelopathy. The pathognomonic MR finding for SAW is the "positive scalpel sign"comprised of an enlarged dorsal CSF space with a normal ventral subarachnoid space. The main differential diagnostic consideration for SAW is idiopathic spinal cord herniation (ISCH); however, for ISCH, MR studies classically demonstrate ventral displacement of the spinal cord through an anterior dural defect. Here, we describe a 60-year-old female with an atypical SAW at the T3-T4 level (i.e., the preoperative MR failed to demonstrate the "positive scalpel sign"). Nevertheless, at surgery, intraoperative ultrasonography confirmed that SAW was present and was decompressed/marsupialized/removed. Case Description: A 60-year-old female presented with sensory impairment to both lower extremities. The thoracic MR images showed an enlarged dorsal CSF space at the T3-T4 level but without the "scalpel sign"suggesting "interruption"of CSF flow by thickened bands of focal dorsal arachnoidal tissues. Although the initial preoperative diagnosis was ISCH, intraoperative ultrasound (IOUS) confirmed the presence of a thickened arachnoid band, confirming the diagnosis of a SAW that was appropriately decompressed/resected. Conclusion: Correctly, establishing the preoperative diagnosis of a SAW based on MR imaging may sometimes be difficult as the typical "scalpel sign"may not be present in all patients. Notably, in cases like this one, IOUS may critically confirm the diagnosis of SAW thus leading to appropriate SAW decompression/removal.

    DOI: 10.25259/SNI_179_2022

    Scopus

    PubMed

  32. Spontaneous regression of asymptomatic tumefactive perivascular spaces in the anterior temporal lobe 査読有り

    Nagoya Journal of Medical Science   84 巻 ( 3 ) 頁: 678 - 685   2022年

     詳細を見る

    担当区分:最終著者   記述言語:英語  

    DOI: 10.18999/nagjms.84.3.678

    Scopus

  33. Clinical and Radiological Clues of Traumatic Craniocervical Junction Injuries Requiring Occipitocervical Fusion to Early Diagnosis.

    Shiraishi D, Nishimura Y, Aguirre-Carreno I, Hara M, Yoshikawa S, Eguchi K, Nagashima Y, Ito H, Haimoto S, Yamamoto Y, Ginsberg HJ, Takayasu M, Saito R

    Neurospine   18 巻 ( 4 ) 頁: 741 - 748   2021年12月

     詳細を見る

    記述言語:英語  

    DOI: 10.14245/ns.2142860.430

    PubMed

  34. Two cases of solitary fibrous tumor/hemangiopericytoma with different clinical features according to the World Health Organization classification: case report and review of the literature.

    Nishii T, Nagashima Y, Nishimura Y, Ito H, Oyama T, Matsuo M, Sakakibara A, Shimada S, Saito R

    Journal of spine surgery (Hong Kong)   7 巻 ( 4 ) 頁: 532 - 539   2021年12月

     詳細を見る

    記述言語:英語  

    DOI: 10.21037/jss-21-83

    PubMed

  35. Piecemeal resection of aggressive vertebral hemangioma using real-time navigation-guided drilling technique

    Nagashima Yoshitaka, Nishimura Yusuke, Haimoto Shoichi, Eguchi Kaoru, Awaya Takayuki, Ando Ryo, Akahori Sho, Hara Masahito, Natsume Atsushi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   83 巻 ( 4 ) 頁: 861 - 868   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:Nagoya Journal of Medical Science  

    Vertebral hemangiomas are the most common benign vertebral tumors and are usually asymptomatic. Aggressive subtypes of the tumor, called aggressive VHs (AVHs), can become symptomatic with extraos-seous extensions and require surgical removal. We present a case of AVH in a 36-year-old man presenting with low back pain and right leg pain that persisted for three months. Imaging studies showed a Th12 vertebral tumor that extended into the spinal canal and was squeezing the spinal cord. Computed tomog-raphy (CT)-guided biopsy indicated vertebral hemangimoa. Following preoperative arterial embolization, piecemeal gross total resection was attained under navigation guidance. He was left with no neurological deficit and remained well at the 12-month postoperative folow-up. Since AVHs are benign tumor, piecemeal removal of the tumor can be selected. However, disadvantage of the approach include difficulty of making decision how much to remove the front part of the vertebral body close to thoracic descending aorta. Furthermore, when the tumor tissue is too hard to curett, manipulation in tight spaces near the spinal cord carries the risk of damaging it. Navigation-guided drill is highly helpful for real-time monitoring of ongoing tumor resection. It enables safely resection of the tumor especially in the anterior cortical surface of the vertebral body and easily resection even hard tumors. This method results in reducing residual tumor and maintaining safety resection.

    DOI: 10.18999/nagjms.83.4.861

    Web of Science

    Scopus

    PubMed

  36. Driver genetic mutations in spinal cord gliomas direct the degree of functional impairment in tumor-associated spinal cord injury 査読有り

    Nagashima Y., Nishimura Y., Ohka F., Eguchi K., Aoki K., Ito H., Nishii T., Oyama T., Hara M., Kitano Y., Masaki H., Wakabayashi T., Natsume A.

    Cells   10 巻 ( 10 )   2021年10月

     詳細を見る

    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:Cells  

    Genetic analysis in glioma has been developed recently. Spinal cord glioma is less common than intracranial glioma. Thus, the clinical significance of genetic mutations in spinal cord gliomas remains unclear. Furthermore, because the spinal cord is an important communication channel between the brain and the rest of the body, increased attention should be paid to its functional prognosis. In this study, we investigated the functional prognosis and driver genetic mutations in eight patients with spinal cord gliomas (World Health Organization grade I, three cases; grade II, two cases; grade III/IV, three cases). IDH mutations were detected in all grade II cases and H3F3A mutations were detected in all grade III/IV cases. The functional status of grade I and II gliomas remained unchanged or improved 1 year after surgery, whereas grade III/IV gliomas remained unchanged or deteriorated. Spinal glioma progenitor cells with H3F3A mutations were associated with accelerated tumor-associated spinal cord injury, which led to functional impairment. Conversely, the presence of IDH mutations, which are rarely reported in spinal gliomas, indicated a relatively favorable functional prognosis.

    DOI: 10.3390/cells10102525

    Scopus

  37. 頚椎前方固定術後合併症としての頚椎硬膜外血腫

    粟屋尭之, 赤堀翔, 永島吉孝

      34 巻 ( 1 ) 頁: 66 - 68   2021年3月

  38. Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury 査読有り

    Fukuoka Toshiki, Kato Akira, Hirano Masaki, Ohka Fumiharu, Aoki Kosuke, Awaya Takayuki, Adilijiang Alimu, Sachi Maeda, Tanahashi Kuniaki, Yamaguchi Junya, Motomura Kazuya, Shimizu Hiroyuki, Nagashima Yoshitaka, Ando Ryo, Wakabayashi Toshihiko, Lee-Liu Dasfne, Larrain Juan, Nishimura Yusuke, Natsume Atsushi

    ISCIENCE   24 巻 ( 2 ) 頁: 102074   2021年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:iScience  

    Biological Sciences; Neuroscience; Behavioral Neuroscience; Cellular Neuroscience

    DOI: 10.1016/j.isci.2021.102074

    Web of Science

    Scopus

    PubMed

  39. Direct Vertebral Artery Puncture During Open Surgery for the Endovascular Treatment of a Recurrent Vertebro-Vertebral Arteriovenous Fistula 査読有り

    Ikezawa Mizuka, Izumi Takashi, Nishihori Masahiro, Nagashima Yoshitaka, Nishimura Yusuke, Tsukuda Tetsuya, Kropp Asuka E., Goto Shunsaku, Otsuka Takafumi, Kato Naoki, Nakano Mizuki

    WORLD NEUROSURGERY   146 巻   頁: 166 - 170   2021年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:World Neurosurgery  

    Background: Vertebro-vertebral arteriovenous fistula (VVAVF) is a condition in which there is an arteriovenous shunt directly connecting the extracranial vertebral artery to the vertebral venous plexus. Many reports have described fistula occlusion or vertebral artery trapping as treatments for VVAVF. Here, we describe a case in which endovascular treatment for recurrent VVAVF using a transfemoral approach was unsuccessful; thus, the vertebral artery (VA) was directly punctured during open surgery and the treatment was successful. Case Description: The patient was a 47-year-old female who had undergone endovascular treatment for VVAVF. The patient developed subarachnoid hemorrhage. Digital subtraction angiography revealed a left VVAVF. The left VA was trapped with coils at the C2 and C3 levels and an arteriovenous shunt formed from the VA between the 2-coil mass to the vertebral venous plexus. In addition, reflux was observed in the spinal vein. Endovascular treatment was attempted with a transfemoral approach, but we could not reach the shunt. Five days post-treatment, the patient had a second subarachnoid hemorrhage and surgery was performed to occlude the radiculomedullary vein; however, residual reflux went into the spinal vein from another spinal level. Later, the VA was directly punctured and treated with N-butyl cyanoacrylate, and the shunt disappeared. Conclusions: Direct puncture of the vertebral artery was useful in this case, where it was difficult to reach the lesion. Although direct VA puncture is associated with more complications than the transfemoral or transbrachial approach, it may be an option when other methods are difficult.

    DOI: 10.1016/j.wneu.2020.10.156

    Web of Science

    Scopus

    PubMed

  40. Preoperative Intracranial Dissemination of Spinal Myxopapillary Ependymoma Attributed to Tumor Hemorrhage 査読有り

    Awaya Takayuki, Nishimura Yusuke, Eguchi Kaoru, Nagashima Yoshitaka, Ando Ryo, Akahori Sho, Yoshikawa Satoshi, Haimoto Shoichi, Hara Masahito, Natsume Atsushi

    WORLD NEUROSURGERY   145 巻   頁: 13 - 18   2021年1月

     詳細を見る

    記述言語:日本語   出版者・発行元:World Neurosurgery  

    Background: Spinal myxopapillary ependymoma (SME), generally considered a benign entity, can exhibit brain and whole-spine metastases as well as local recurrence after surgery. However, the presence of preoperative retrograde intracranial dissemination at the time of diagnosis is very rare. Case Description: We report a case of SME in a 22-year-old man who presented with acute exacerbation of chronic back pain shooting down both thighs and weakness in both legs. Magnetic resonance imaging of the brain and whole spine showed an enhancing mass occupying the majority of the spinal canal at the L1-L2 level and multiple foci dissemination, including in the right pons, lateral midbrain, and occipital lobe, and at the C7, Th6, L4, and S2 levels of the spinal canal at the time of diagnosis. On gross total removal of the dominant tumor located at the L1-L2 level, severe intradural arachnoiditis and syrinx filled with xanthochromic cerebrospinal fluid was noted, indicating the presence of previous tumor hemorrhage. Histopathologic analysis of the tumor supported SME diagnosis, and <1% of cells showed Ki-67 expression. We speculated that distant retrograde dissemination could have been attributed to metastatic spread through cerebrospinal fluid caused by tumor hemorrhage, which may explain distant dissemination despite low expression of Ki-67. Conclusions: Screening of the whole brain and spine at the time of diagnosis is imperative when tumor is detected at any level of the neuraxis. The present case of SME with a preoperative intracranial lesion is the fifth case documented in the medical literature.

    DOI: 10.1016/j.wneu.2020.08.169

    Web of Science

    Scopus

    PubMed

  41. Spontaneous Rupture of a Huge Presacral Tarlov Cyst Leading to Dramatic Neurologic Recovery 査読有り

    Akahori Sho, Nishimura Yusuke, Eguchi Kaoru, Nagashima Yoshitaka, Ando Ryo, Awaya Takayuki, Hara Masahito, Natsume Atsushi

    WORLD NEUROSURGERY   145 巻   頁: 306 - 310   2021年1月

     詳細を見る

    記述言語:日本語   出版者・発行元:World Neurosurgery  

    Background: This manuscript discusses the case of huge presacral Tarlov cysts (TCs) and the substantial neurologic recovery noted in the patient following spontaneous rupture of the most prominent cyst. Perineural or TCs are nerve root cysts, which are usually incidental findings on magnetic resonance imaging (MRI) and are most frequently observed in the sacral spine. Symptomatic lesions are rarely encountered. Case Description: In this case, a 44-year-old woman presented with anal and vulva pain on the right side, and bladder and bowel dysfunction. MRI of the lumbosacral spine showed multiple huge bilateral TCs located within the presacral space from S1-3. There was a substantially large right-sided S3 cyst that was presumed to be responsible for her symptoms. Surgical intervention was considered; however, her symptoms improved significantly during the waiting period for surgery because of spontaneous rupture of the right-sided S3 cyst, as confirmed on follow-up MRI. On follow-up over a 1-year period, the patient had been very well with no recurrent symptoms. Conclusions: To our knowledge, this is the first report of spontaneous cyst rupture and resultant neurologic improvement in a case of symptomatic presacral TCs.

    DOI: 10.1016/j.wneu.2020.09.098

    Web of Science

    Scopus

    PubMed

  42. 脊髄髄内星細胞腫における術中迅速<i>H3F3A K27M</i>変異診断の有用性の検討

    永島 吉孝, 大岡 史治, 西村 由介, 江口 馨, 安藤 遼, 粟屋 尭之, 赤堀 翔, 若林 俊彦, 夏目 敦至

    脊髄外科   35 巻 ( 2 ) 頁: 215 - 217   2021年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本脊髄外科学会  

    DOI: 10.2531/spinalsurg.35.215

  43. Postoperative Cervicothoracic Kyphosis Following Infantile Intramedullary Tumor Resection Accelerates Neurological Deterioration

    GONDA Tomomi, NAGASHIMA Yoshitaka, NISHIMURA Yusuke, ITO Hiroshi, NISII Tomoya, OYAMA Takahiro, HARA Masahito, SAITO Ryuta

    NMC Case Report Journal   8 巻 ( 1 ) 頁: 705 - 711   2021年

     詳細を見る

    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    <p>Intramedullary spinal cord tumors are rare in children. Regardless of the type of tumor, surgical removal is thought to improve progression-free survival. However, postoperative kyphosis is a serious problem in children, who can expect long-term survival. We present a pediatric case of neurofibromatosis type 2-related spinal ependymoma at the cervicothoracic regions where acute neurological deterioration was developed due to a combination of tumor recurrence and postoperative kyphotic deformity. In the first surgery, subtotal tumor resection was performed via osteoplastic laminotomy. Postoperative radiological evaluation at several months showed cervicothoracic junctional kyphosis, which subsequently made a significant improvement by lifestyle instructions. However, 22 months after the surgery, he exhibited rapid neurological deterioration caused by the regrowth of the recurrent tumor and re-emergence of kyphotic deformity, which led to the fixed laminar flap sank into the spinal canal. Therefore, a second surgery was performed 23 months after the first surgery, and gross total removal was achieved. Osteoplastic laminotomy is presumed to reduce the occurrence of postoperative kyphosis compared with laminectomy, but there have been no reports on the spinal cord compression by plunging of the re-fixed laminar flap into the spinal canal. The kyphosis deformity increases the chance of re-fixed laminar flap coming off, thereby accelerating neurological injury on top of the neural damage by tumor recurrence itself. Therefore, pediatric patients with spinal cord tumors should be carefully managed in terms of recurrent tumors and postoperative kyphosis, and timely surgical intervention is necessary before kyphotic deformity becomes evident.</p>

    DOI: 10.2176/nmccrj.cr.2021-0086

  44. Thoracic Disc Herniation Manifesting as Abdominal Pain Alone Associated with Thoracic Radiculopathy. 査読有り

    Ishii M, Nishimura Y, Hara M, Eguchi K, Nagashima Y, Awaya T, Ando R, Haimoto S, Wakabayashi T

    NMC case report journal   7 巻 ( 4 ) 頁: 161 - 165   2020年9月

     詳細を見る

    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    <p>Symptomatic thoracic disc herniation (TDH) with thoracic radiculopathy alone is an extremely rare condition. Here, we report a rare case of TDH in a 52-year-old man who presented with medically refractory severe right flank pain. Based on pain distribution, pain intensity changes according to truncal position, ineffectiveness of intercostal nerve block, and radiological findings, his pain was determined to be caused by TDH at T9-10 level. Symptomatic TDH often requires invasive surgery. However, TDH with radiculopathy alone can be treated via a posterior approach without spinal cord manipulation or spinal fusion. We could eliminate the pain by removing TDH with hemilaminectomy and microdiscectomy using an O-arm-based navigation system.</p>

    DOI: 10.2176/nmccrj.cr.2019-0247

    PubMed

  45. Possible Double Crush Syndrome Caused by Iatrogenic Acquired Lumbosacral Epidermoid Tumor and Concomitant Sacral Tarlov Cyst. 査読有り

    Nishimura Y, Hara M, Awaya T, Ando R, Eguchi K, Nagashima Y, Wakabayashi T, Ginsberg HJ

    NMC case report journal   7 巻 ( 4 ) 頁: 195 - 199   2020年9月

     詳細を見る

    記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    <p>We describe a rare case of 42-year-old female who had possible double crush syndrome caused by iatrogenic spinal epidermoid tumor (ET) associated with lumbar puncture as well as concomitant sacral Tarlov cyst in close proximity. She presented with progressive left-sided perianal pain. She had a history of a Caesarean section with lumbar spinal anesthesia. Magnetic resonance imaging (MRI) demonstrated a relatively small intradural extramedullary solid lesion at L5/S1 level and cystic lesion at S2 level. We considered there were two different lesions, such as a tumor and Tarlov cyst; however, we could not rule out the possibility of a single lesion with two different components. Furthermore, there was a distinct compression at more than one locations along the course of the left S2 nerve root and we suspected possible double crush syndrome. We conducted tumor removal and the lesion turned out to be two different pathologies, such as an ET and Tarlov cyst. Both lesions were intraopertively pinching the left S2 nerve root at different sites as expected. The tumor was successfully removed and the cyst wall was imbricated and sutured. We need to take the possibility of ET into consideration if the patient underwent invasive spinal procedure previously. We also have to pay attention to the possibility of double crush syndrome if the nerve root possibly holding the responsibility for symptoms is compressed at two or more sites. This is the first report of possible double crush syndrome caused by acquired spinal tumor and congenital Tarlov cyst.</p>

    DOI: 10.2176/nmccrj.cr.2019-0236

    PubMed

  46. Intraosseous Melanotic Schwannoma in the Sacrum Mimicking Primary Bone Tumor. 査読有り

    Nagashima Y, Nishimura Y, Eguchi K, Awaya T, Yoshikawa S, Haimoto S, Wakabayashi T, Hara M

    NMC case report journal   7 巻 ( 3 ) 頁: 107 - 111   2020年7月

     詳細を見る

    担当区分:筆頭著者   記述言語:英語   出版者・発行元:一般社団法人 日本脳神経外科学会  

    <p>Primary tumors of sacrum are rarely seen, and the differential diagnosis is extensive, such as chordomas, giant cell tumors, and schwannomas. Sacral intraosseous schwannomas (IOSs) are very rare and encompass approximately 1%–5% of all spinal schwannomas. Melanotic schwannomas (MSs) are categorized as an unusual variant of benign schwannomas; however, they sometimes follow a malignant course. The authors present a case of MS with intraosseous extension into sacrum in a 48-year-old male arising from the left S2 nerve root. Magnetic resonance imaging (MRI) and computed tomography (CT) scan demonstrated a destructive mass in the sacrum. He was made a diagnosis with MS by 18F-fluoro-deoxy-glucose positron-emission-tomography (<sup>18</sup>F-FDG PET) and open biopsy. The tumor was blackish-colored and vascular-rich fragile tumor covered by fibrous capsule. The floor of the tumor was not encapsulated and invading into the sacral bone. Total removal of the tumor together with the left S2 nerve of origin via posterior approach was achieved. The patient made dramatic recovery of neurological symptoms and tumor recurrence is not seen for 6-month follow-up period. MS is a benign tumor with potential for aggressive behavior and capacity to metastasize. Therefore, total removal of the tumor and careful postoperative follow-up are recommended. Postoperative spinopelvic stability also needs to be taken into consideration. The authors discuss our successful management with a focus on diagnostic process, surgical planning, and histological consideration to provide the most up-to-date guidance on managing this challenging tumor.</p>

    DOI: 10.2176/nmccrj.cr.2019-0238

    PubMed

  47. 後方靭帯複合体損傷を伴う不安定胸腰椎移行部外傷に対する後方固定術の術後アライメント 査読有り

    灰本 章一, 西村 由介, 江口 馨, 永島 吉孝, 安藤 遼, 服部 和良, Howard Ginsberg

    脊髄外科   33 巻 ( 3 ) 頁: 298 - 301   2019年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本脊髄外科学会  

    DOI: 10.2531/spinalsurg.33.298

  48. 転移性脊椎腫瘍に対する外科的治療がもたらすQOLの改善 査読有り

    江口 馨, 西村 由介, 灰本 章一, 安藤 遼, 永島 吉孝, 若林 俊彦

    脊髄外科   33 巻 ( 1 ) 頁: 74 - 77   2019年

     詳細を見る

    記述言語:日本語   出版者・発行元:日本脊髄外科学会  

    DOI: 10.2531/spinalsurg.33.74

▼全件表示

MISC 4

  1. Development of machine learning models for predicting unfavorable functional outcomes in patients with chronic subdural hematomas

    Fuse Y, Nagashima Y, Nishiwaki H, Ohka F, Muramatsu Y, Araki Y, Nishimura Y, Ienaga J, Nagatani T, Seki Y, Watanabe K, Ohno K, Saito R  

        2022年11月

     詳細を見る

  2. 特集 癒着性くも膜炎の病態と治療法を学ぼう 術後に生じる癒着性くも膜炎

    西村 由介, 永島 吉孝, 齋藤 竜太  

    脊椎脊髄ジャーナル35 巻 ( 2 ) 頁: 99 - 105   2022年6月

     詳細を見る

    出版者・発行元:三輪書店  

    DOI: 10.11477/mf.5002201799

    CiNii Research

  3. 特集 脊椎脊髄疾患の再手術症例における手術のコツと留意点 頸椎症における再手術

    西村 由介, 永島 吉孝, 齋藤 竜太  

    脊椎脊髄ジャーナル34 巻 ( 12 ) 頁: 896 - 901   2022年3月

     詳細を見る

    出版者・発行元:三輪書店  

    DOI: 10.11477/mf.5002201765

    CiNii Research

  4. Clinical study on metastatic spinal tumor with ESCC scale 3

    Brain and Spine1 巻   頁: 100425   2021年1月

講演・口頭発表等 7

  1. Diagnostic utility of positron emission tomography (PET) findings for the intramedullary lesions in the spinal cord

    Yoshitaka Nagashima, Yusuke Nishimura, Ryuta Saito

    EANS 2023  2023年9月26日 

  2. A single-center retrospective study of the genetic characteristics and clinical presentation of spinal gliomas

    Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Fumiharu Ohka, Motonori Ishii, Tomoya Nishii, Nobuhisa Fukaya, Takashi Abe, Hiroyuki Kato, Ryuta Saito

    The 14th Annual Meeting of Asia Spine  2023年6月 

     詳細を見る

    会議種別:口頭発表(一般)  

  3. Genetic features and clinical outcome of spinal cord glioma

    The 10th Pan-Pacific Neurosurgical Congress  2023年2月 

  4. 腰椎圧迫骨折で増悪した脊柱管狭窄症に対するballoon kyphoplastyと片側侵入除圧術の同時手術

    第46回日本脳神経外傷学会  2023年2月24日 

     詳細を見る

    会議種別:シンポジウム・ワークショップ パネル(公募)  

  5. 脊髄外科医にとっての研究・論文執筆

    第38回日本脊髄外科学会 Neurospine Project  2023年6月 

  6. The Utility of Recent Navigation Systems in Craniocervical Fusion Surgery

    Yoshitaka Nagashima, Yusuke Nishimura, Motonori Ishii, Tomoya Nishii, Takashi Abe, Nobuhisa Fukaya, Hiroyuki Kato, Ryuta Saito

    The 14th Annual Meeting of Asia Spine  2023年6月 

     詳細を見る

    会議種別:シンポジウム・ワークショップ パネル(公募)  

  7. マルティモダリティを駆使した脊髄髄内腫瘍手術の工夫

    永島吉孝, 西村由介, 江口馨, 大岡史治, 山口純矢, 阿部節, 松尾衛, 権田友美, 塚本英祐, 齋藤竜太

    日本脳神経外科学会第82回学術総会  2023年10月27日 

▼全件表示

その他研究活動 5

  1. 日本脊髄外科指導医

    2022年
    -
    現在

  2. 脊椎脊髄外科専門医

    2021年
    -
    現在

  3. 日本脊髄外科認定医

    2020年
    -
    現在

  4. 日本脳神経外科専門医

    2017年
    -
    現在

  5. 緩和ケア研修会修了

    2014年

共同研究・競争的資金等の研究課題 2

  1. 脊髄星細胞腫の遺伝子解析

    2020年3月 - 2022年4月

    共同研究費

  2. 慢性硬膜下血腫手術の際の血腫腔洗浄が再発率に与える影響に関する研究

    名古屋大学医学部附属病院先端研究支援経費 

      詳細を見る

    資金種別:競争的資金

科研費 4

  1. 高雄基金海外学術交流助成(後期)

    2023年9月

  2. 脊髄損傷後の歯髄幹細胞治療に脊髄硬膜外刺激療法を組み合わせた新しい治療法開発

    研究課題/研究課題番号:23K08565  2023年4月 - 2026年3月

    科学研究費助成事業  基盤研究(C)

    永島 吉孝

      詳細を見る

    担当区分:研究代表者 

    配分額:4810000円 ( 直接経費:3700000円 、 間接経費:1110000円 )

  3. 塩基性ヘリックスループヘリックス転写機構制御と細胞治療を融合する神経再生治療開発

    研究課題/研究課題番号:22K09280  2022年4月 - 2025年3月

    科学研究費助成事業  基盤研究(C)

    西村 由介, 永島 吉孝, 夏目 敦至, 古橋 和拡

      詳細を見る

    担当区分:研究分担者 

    申請者らは『損傷脊髄を完全に再生する驚異的な能力を持つアフリカツメガエル幼生期に強く発現し、脊髄再生に関わるNeurod4などの塩基性ヘリックスループヘリックス(bHLH)神経転写因子を歯髄幹細胞に遺伝子導入してラット脊髄損傷モデルに投与することで、歯髄幹細胞自体をニューロンへ分化させ神経回路を再構築し、神経栄養因子分泌による脊髄再生効果に相加的かつ加速度的な神経機能回復が得られる』という仮説を立て、これを実証する。

  4. 脊髄腫瘍の手術戦略決定に有用な術前、術中H3F3A遺伝子プロファイリング

    研究課題/研究課題番号:20K17962  2020年4月 - 2023年3月

    若手研究

    永島 吉孝

      詳細を見る

    担当区分:研究代表者 

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    脳脊髄腫瘍の診断は、特徴的な病理形態に基づいた診断と特定の遺伝子異常の有無を組み合わせた統合診断が推奨されている。病理形態診断は染色システム等の技術向上により術中迅速診断が可能になっている一方で、迅速遺伝子診断は未だ開発途上であり、実用化されていない。予後が不良であり、かつ神経障害を起こしやすい脊髄腫瘍の手術には術前、術中に腫瘍の性質を十分に把握するための情報が不可欠である。術前、術中にH3F3A変異を同定することで、術後の計画を想定した上で手術戦略を検討できると考え、解析の構築を目指した。

 

学術貢献活動 4

  1. Guest editor: DSPN-Neurospine Special Issue "Spine and Spinal Cord Tumors" 国際学術貢献

    2021年7月 - 2022年3月

     詳細を見る

    種別:査読等 

  2. 中部脳神経外科看護セミナー事務局長

    役割:企画立案・運営等, 監修

    2019年 - 現在

  3. 日本脊髄外科学会査読委員

    役割:査読

  4. 救急救命士養成教育講義(頭部・頚椎損傷)