Updated on 2022/09/01

写真a

 
NAGASHIMA Yoshitaka
 
Organization
Nagoya University Hospital Neurosurgery Assistant professor of hospital
Title
Assistant professor of hospital

Degree 1

  1. M.D. ( 2011.3   University of Fukui ) 

Research Interests 6

  1. 脳神経外科学

  2. 脊椎脊髄疾患

  3. 遺伝子解析

  4. 神経再生

  5. 機械学習

  6. 脳神経外科学

Research Areas 3

  1. Life Science / Tumor diagnostics and therapeutics

  2. Life Science / Neurosurgery

  3. Life Science / Genome biology

Professional Memberships 4

  1. 日本脳神経外科学会

  2. 日本脳神経外科コングレス

  3. 日本脊髄外科学会

  4. 日本脊髄障害医学会

 

Papers 19

  1. Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors.

    Nagashima Y, Nishimura Y, Eguchi K, Yamaguchi J, Haimoto S, Ohka F, Takayasu M, Saito R

    Neurospine     2022.5

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    Authorship:Lead author   Language:English  

    DOI: 10.14245/ns.2244168.084

    PubMed

  2. Radiological analysis of minimally invasive microscopic laminectomy for lumbar canal stenosis with a focus on multilevel stenosis and spondylolisthesis.

    Awaya T, Nishimura Y, Eguchi K, Nagashima Y, Ando R, Akahori S, Yoshikawa S, Haimoto S, Hara M, Takayasu M, Saito R

    World neurosurgery     2022.4

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    Language:English  

    DOI: 10.1016/j.wneu.2022.04.079

    PubMed

  3. Laminectomy triggers symptomatic growth of spinal schwannoma in a patient with schwannomatosis. International journal

    Takahiro Oyama, Yusuke Nishimura, Yoshitaka Nagashima, Tomoya Nishii, Masahito Hara, Masakazu Takayasu, Ayako Sakakibara, Ryuta Saito

    Surgical neurology international   Vol. 13   page: 261 - 261   2022

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    Language:English  

    Background: Schwannomatosis (SWN) is genetically similar to neurofibromatosis type 2 (NF2) and represents a NF2 gene mutation. Previous studies have shown that these mutations in both neurons and Schwann cells can lead to the development of schwannomas after nerve crush injuries. Here, we reviewed the potential pathoanatomical mechanisms for the development of a trauma-induced spinal schwannomas in a 55-year-old male with SWN. Case Description: A 49-year-old male had originally undergone a L3-L5 lumbar laminectomy for stenosis; the schwannomas seen on the preoperative magnetic resonance imaging (MRI) were not resected. Now at age 55, he newly presented with low back pain and numbness in the left L5 dermatome, and he was diagnosed with an L4 vertebral level cauda equina tumor on MRI. Following gross-total resection, the histopathological assessment revealed a Ki-67 labeling index 5-10% in hotspots (i.e., slightly higher than the normal range of schwannomas) and a 20% mosaic loss of SMARCB1. Based on these criteria, he was diagnosed as having SWN. Conclusion: In this patient with SWN, compression/physical trauma to nerves of the cauda equina during the L3-L5 laminectomy 6 years ago likely caused the progression of schwannoma.

    DOI: 10.25259/SNI_453_2022

    PubMed

  4. Atypical radiographic case of arachnoid web without scalpel sign.

    Nagashima Y, Nishimura Y, Ito H, Oyama T, Nishii T, Gonda T, Kato H, Saito R

    Surgical neurology international   Vol. 13   page: 108   2022

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    Authorship:Lead author   Language:English   Publisher:Surgical Neurology International  

    Background: Spinal arachnoid webs (SAW) occur when abnormally thickened bands of arachnoid membranes commonly located dorsal to the thoracic spine cause blockage of normal cerebrospinal fluid (CSF) flow, resulting in focal cord compression and myelopathy. The pathognomonic MR finding for SAW is the "positive scalpel sign"comprised of an enlarged dorsal CSF space with a normal ventral subarachnoid space. The main differential diagnostic consideration for SAW is idiopathic spinal cord herniation (ISCH); however, for ISCH, MR studies classically demonstrate ventral displacement of the spinal cord through an anterior dural defect. Here, we describe a 60-year-old female with an atypical SAW at the T3-T4 level (i.e., the preoperative MR failed to demonstrate the "positive scalpel sign"). Nevertheless, at surgery, intraoperative ultrasonography confirmed that SAW was present and was decompressed/marsupialized/removed. Case Description: A 60-year-old female presented with sensory impairment to both lower extremities. The thoracic MR images showed an enlarged dorsal CSF space at the T3-T4 level but without the "scalpel sign"suggesting "interruption"of CSF flow by thickened bands of focal dorsal arachnoidal tissues. Although the initial preoperative diagnosis was ISCH, intraoperative ultrasound (IOUS) confirmed the presence of a thickened arachnoid band, confirming the diagnosis of a SAW that was appropriately decompressed/resected. Conclusion: Correctly, establishing the preoperative diagnosis of a SAW based on MR imaging may sometimes be difficult as the typical "scalpel sign"may not be present in all patients. Notably, in cases like this one, IOUS may critically confirm the diagnosis of SAW thus leading to appropriate SAW decompression/removal.

    DOI: 10.25259/SNI_179_2022

    Scopus

    PubMed

  5. Clinical and Radiological Clues of Traumatic Craniocervical Junction Injuries Requiring Occipitocervical Fusion to Early Diagnosis.

    Shiraishi D, Nishimura Y, Aguirre-Carreno I, Hara M, Yoshikawa S, Eguchi K, Nagashima Y, Ito H, Haimoto S, Yamamoto Y, Ginsberg HJ, Takayasu M, Saito R

    Neurospine   Vol. 18 ( 4 ) page: 741 - 748   2021.12

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    Language:English  

    DOI: 10.14245/ns.2142860.430

    PubMed

  6. Two cases of solitary fibrous tumor/hemangiopericytoma with different clinical features according to the World Health Organization classification: case report and review of the literature.

    Nishii T, Nagashima Y, Nishimura Y, Ito H, Oyama T, Matsuo M, Sakakibara A, Shimada S, Saito R

    Journal of spine surgery (Hong Kong)   Vol. 7 ( 4 ) page: 532 - 539   2021.12

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    Language:English  

    DOI: 10.21037/jss-21-83

    PubMed

  7. Piecemeal resection of aggressive vertebral hemangioma using real-time navigation-guided drilling technique

    Nagashima Yoshitaka, Nishimura Yusuke, Haimoto Shoichi, Eguchi Kaoru, Awaya Takayuki, Ando Ryo, Akahori Sho, Hara Masahito, Natsume Atsushi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 83 ( 4 ) page: 861 - 868   2021.11

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    Language:Japanese   Publisher:Nagoya Journal of Medical Science  

    Vertebral hemangiomas are the most common benign vertebral tumors and are usually asymptomatic. Aggressive subtypes of the tumor, called aggressive VHs (AVHs), can become symptomatic with extraos-seous extensions and require surgical removal. We present a case of AVH in a 36-year-old man presenting with low back pain and right leg pain that persisted for three months. Imaging studies showed a Th12 vertebral tumor that extended into the spinal canal and was squeezing the spinal cord. Computed tomog-raphy (CT)-guided biopsy indicated vertebral hemangimoa. Following preoperative arterial embolization, piecemeal gross total resection was attained under navigation guidance. He was left with no neurological deficit and remained well at the 12-month postoperative folow-up. Since AVHs are benign tumor, piecemeal removal of the tumor can be selected. However, disadvantage of the approach include difficulty of making decision how much to remove the front part of the vertebral body close to thoracic descending aorta. Furthermore, when the tumor tissue is too hard to curett, manipulation in tight spaces near the spinal cord carries the risk of damaging it. Navigation-guided drill is highly helpful for real-time monitoring of ongoing tumor resection. It enables safely resection of the tumor especially in the anterior cortical surface of the vertebral body and easily resection even hard tumors. This method results in reducing residual tumor and maintaining safety resection.

    DOI: 10.18999/nagjms.83.4.861

    Web of Science

    Scopus

    PubMed

  8. Driver genetic mutations in spinal cord gliomas direct the degree of functional impairment in tumor-associated spinal cord injury Reviewed

    Nagashima Y., Nishimura Y., Ohka F., Eguchi K., Aoki K., Ito H., Nishii T., Oyama T., Hara M., Kitano Y., Masaki H., Wakabayashi T., Natsume A.

    Cells   Vol. 10 ( 10 )   2021.10

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    Authorship:Lead author   Language:Japanese   Publisher:Cells  

    Genetic analysis in glioma has been developed recently. Spinal cord glioma is less common than intracranial glioma. Thus, the clinical significance of genetic mutations in spinal cord gliomas remains unclear. Furthermore, because the spinal cord is an important communication channel between the brain and the rest of the body, increased attention should be paid to its functional prognosis. In this study, we investigated the functional prognosis and driver genetic mutations in eight patients with spinal cord gliomas (World Health Organization grade I, three cases; grade II, two cases; grade III/IV, three cases). IDH mutations were detected in all grade II cases and H3F3A mutations were detected in all grade III/IV cases. The functional status of grade I and II gliomas remained unchanged or improved 1 year after surgery, whereas grade III/IV gliomas remained unchanged or deteriorated. Spinal glioma progenitor cells with H3F3A mutations were associated with accelerated tumor-associated spinal cord injury, which led to functional impairment. Conversely, the presence of IDH mutations, which are rarely reported in spinal gliomas, indicated a relatively favorable functional prognosis.

    DOI: 10.3390/cells10102525

    Scopus

  9. Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury Reviewed

    Fukuoka Toshiki, Kato Akira, Hirano Masaki, Ohka Fumiharu, Aoki Kosuke, Awaya Takayuki, Adilijiang Alimu, Sachi Maeda, Tanahashi Kuniaki, Yamaguchi Junya, Motomura Kazuya, Shimizu Hiroyuki, Nagashima Yoshitaka, Ando Ryo, Wakabayashi Toshihiko, Lee-Liu Dasfne, Larrain Juan, Nishimura Yusuke, Natsume Atsushi

    ISCIENCE   Vol. 24 ( 2 ) page: 102074   2021.2

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    Language:Japanese   Publisher:iScience  

    Biological Sciences; Neuroscience; Behavioral Neuroscience; Cellular Neuroscience

    DOI: 10.1016/j.isci.2021.102074

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  10. Direct Vertebral Artery Puncture During Open Surgery for the Endovascular Treatment of a Recurrent Vertebro-Vertebral Arteriovenous Fistula Reviewed

    Ikezawa Mizuka, Izumi Takashi, Nishihori Masahiro, Nagashima Yoshitaka, Nishimura Yusuke, Tsukuda Tetsuya, Kropp Asuka E., Goto Shunsaku, Otsuka Takafumi, Kato Naoki, Nakano Mizuki

    WORLD NEUROSURGERY   Vol. 146   page: 166 - 170   2021.2

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    Language:Japanese   Publisher:World Neurosurgery  

    Background: Vertebro-vertebral arteriovenous fistula (VVAVF) is a condition in which there is an arteriovenous shunt directly connecting the extracranial vertebral artery to the vertebral venous plexus. Many reports have described fistula occlusion or vertebral artery trapping as treatments for VVAVF. Here, we describe a case in which endovascular treatment for recurrent VVAVF using a transfemoral approach was unsuccessful; thus, the vertebral artery (VA) was directly punctured during open surgery and the treatment was successful. Case Description: The patient was a 47-year-old female who had undergone endovascular treatment for VVAVF. The patient developed subarachnoid hemorrhage. Digital subtraction angiography revealed a left VVAVF. The left VA was trapped with coils at the C2 and C3 levels and an arteriovenous shunt formed from the VA between the 2-coil mass to the vertebral venous plexus. In addition, reflux was observed in the spinal vein. Endovascular treatment was attempted with a transfemoral approach, but we could not reach the shunt. Five days post-treatment, the patient had a second subarachnoid hemorrhage and surgery was performed to occlude the radiculomedullary vein; however, residual reflux went into the spinal vein from another spinal level. Later, the VA was directly punctured and treated with N-butyl cyanoacrylate, and the shunt disappeared. Conclusions: Direct puncture of the vertebral artery was useful in this case, where it was difficult to reach the lesion. Although direct VA puncture is associated with more complications than the transfemoral or transbrachial approach, it may be an option when other methods are difficult.

    DOI: 10.1016/j.wneu.2020.10.156

    Web of Science

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  11. Preoperative Intracranial Dissemination of Spinal Myxopapillary Ependymoma Attributed to Tumor Hemorrhage Reviewed

    Awaya Takayuki, Nishimura Yusuke, Eguchi Kaoru, Nagashima Yoshitaka, Ando Ryo, Akahori Sho, Yoshikawa Satoshi, Haimoto Shoichi, Hara Masahito, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 145   page: 13 - 18   2021.1

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    Language:Japanese   Publisher:World Neurosurgery  

    Background: Spinal myxopapillary ependymoma (SME), generally considered a benign entity, can exhibit brain and whole-spine metastases as well as local recurrence after surgery. However, the presence of preoperative retrograde intracranial dissemination at the time of diagnosis is very rare. Case Description: We report a case of SME in a 22-year-old man who presented with acute exacerbation of chronic back pain shooting down both thighs and weakness in both legs. Magnetic resonance imaging of the brain and whole spine showed an enhancing mass occupying the majority of the spinal canal at the L1-L2 level and multiple foci dissemination, including in the right pons, lateral midbrain, and occipital lobe, and at the C7, Th6, L4, and S2 levels of the spinal canal at the time of diagnosis. On gross total removal of the dominant tumor located at the L1-L2 level, severe intradural arachnoiditis and syrinx filled with xanthochromic cerebrospinal fluid was noted, indicating the presence of previous tumor hemorrhage. Histopathologic analysis of the tumor supported SME diagnosis, and <1% of cells showed Ki-67 expression. We speculated that distant retrograde dissemination could have been attributed to metastatic spread through cerebrospinal fluid caused by tumor hemorrhage, which may explain distant dissemination despite low expression of Ki-67. Conclusions: Screening of the whole brain and spine at the time of diagnosis is imperative when tumor is detected at any level of the neuraxis. The present case of SME with a preoperative intracranial lesion is the fifth case documented in the medical literature.

    DOI: 10.1016/j.wneu.2020.08.169

    Web of Science

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  12. Spontaneous Rupture of a Huge Presacral Tarlov Cyst Leading to Dramatic Neurologic Recovery Reviewed

    Akahori Sho, Nishimura Yusuke, Eguchi Kaoru, Nagashima Yoshitaka, Ando Ryo, Awaya Takayuki, Hara Masahito, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 145   page: 306 - 310   2021.1

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    Language:Japanese   Publisher:World Neurosurgery  

    Background: This manuscript discusses the case of huge presacral Tarlov cysts (TCs) and the substantial neurologic recovery noted in the patient following spontaneous rupture of the most prominent cyst. Perineural or TCs are nerve root cysts, which are usually incidental findings on magnetic resonance imaging (MRI) and are most frequently observed in the sacral spine. Symptomatic lesions are rarely encountered. Case Description: In this case, a 44-year-old woman presented with anal and vulva pain on the right side, and bladder and bowel dysfunction. MRI of the lumbosacral spine showed multiple huge bilateral TCs located within the presacral space from S1-3. There was a substantially large right-sided S3 cyst that was presumed to be responsible for her symptoms. Surgical intervention was considered; however, her symptoms improved significantly during the waiting period for surgery because of spontaneous rupture of the right-sided S3 cyst, as confirmed on follow-up MRI. On follow-up over a 1-year period, the patient had been very well with no recurrent symptoms. Conclusions: To our knowledge, this is the first report of spontaneous cyst rupture and resultant neurologic improvement in a case of symptomatic presacral TCs.

    DOI: 10.1016/j.wneu.2020.09.098

    Web of Science

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  13. Intraoperative <i>H3F3A K27M</i> Mutation-based Diagnosis of Spinal Cord Intramedullary Tumor

    Nagashima Yoshitaka, Ohka Fumiharu, Nishimura Yusuke, Eguchi Kaoru, Ando Ryo, Awaya Takayuki, Akahori Sho, Wakabayashi Toshihiko, Natsume Atsushi

    Spinal Surgery   Vol. 35 ( 2 ) page: 215 - 217   2021

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    Language:Japanese   Publisher:The Japanese Society of Spinal Surgery  

    DOI: 10.2531/spinalsurg.35.215

  14. Postoperative Cervicothoracic Kyphosis Following Infantile Intramedullary Tumor Resection Accelerates Neurological Deterioration

    GONDA Tomomi, NAGASHIMA Yoshitaka, NISHIMURA Yusuke, ITO Hiroshi, NISII Tomoya, OYAMA Takahiro, HARA Masahito, SAITO Ryuta

    NMC Case Report Journal   Vol. 8 ( 1 ) page: 705 - 711   2021

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    Language:English   Publisher:一般社団法人 日本脳神経外科学会  

    <p>Intramedullary spinal cord tumors are rare in children. Regardless of the type of tumor, surgical removal is thought to improve progression-free survival. However, postoperative kyphosis is a serious problem in children, who can expect long-term survival. We present a pediatric case of neurofibromatosis type 2-related spinal ependymoma at the cervicothoracic regions where acute neurological deterioration was developed due to a combination of tumor recurrence and postoperative kyphotic deformity. In the first surgery, subtotal tumor resection was performed via osteoplastic laminotomy. Postoperative radiological evaluation at several months showed cervicothoracic junctional kyphosis, which subsequently made a significant improvement by lifestyle instructions. However, 22 months after the surgery, he exhibited rapid neurological deterioration caused by the regrowth of the recurrent tumor and re-emergence of kyphotic deformity, which led to the fixed laminar flap sank into the spinal canal. Therefore, a second surgery was performed 23 months after the first surgery, and gross total removal was achieved. Osteoplastic laminotomy is presumed to reduce the occurrence of postoperative kyphosis compared with laminectomy, but there have been no reports on the spinal cord compression by plunging of the re-fixed laminar flap into the spinal canal. The kyphosis deformity increases the chance of re-fixed laminar flap coming off, thereby accelerating neurological injury on top of the neural damage by tumor recurrence itself. Therefore, pediatric patients with spinal cord tumors should be carefully managed in terms of recurrent tumors and postoperative kyphosis, and timely surgical intervention is necessary before kyphotic deformity becomes evident.</p>

    DOI: 10.2176/nmccrj.cr.2021-0086

  15. Thoracic Disc Herniation Manifesting as Abdominal Pain Alone Associated with Thoracic Radiculopathy. Reviewed

    Ishii M, Nishimura Y, Hara M, Eguchi K, Nagashima Y, Awaya T, Ando R, Haimoto S, Wakabayashi T

    NMC case report journal   Vol. 7 ( 4 ) page: 161 - 165   2020.9

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    Language:English   Publisher:一般社団法人 日本脳神経外科学会  

    <p>Symptomatic thoracic disc herniation (TDH) with thoracic radiculopathy alone is an extremely rare condition. Here, we report a rare case of TDH in a 52-year-old man who presented with medically refractory severe right flank pain. Based on pain distribution, pain intensity changes according to truncal position, ineffectiveness of intercostal nerve block, and radiological findings, his pain was determined to be caused by TDH at T9-10 level. Symptomatic TDH often requires invasive surgery. However, TDH with radiculopathy alone can be treated via a posterior approach without spinal cord manipulation or spinal fusion. We could eliminate the pain by removing TDH with hemilaminectomy and microdiscectomy using an O-arm-based navigation system.</p>

    DOI: 10.2176/nmccrj.cr.2019-0247

    PubMed

  16. Possible Double Crush Syndrome Caused by Iatrogenic Acquired Lumbosacral Epidermoid Tumor and Concomitant Sacral Tarlov Cyst. Reviewed

    Nishimura Y, Hara M, Awaya T, Ando R, Eguchi K, Nagashima Y, Wakabayashi T, Ginsberg HJ

    NMC case report journal   Vol. 7 ( 4 ) page: 195 - 199   2020.9

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    Language:English   Publisher:一般社団法人 日本脳神経外科学会  

    <p>We describe a rare case of 42-year-old female who had possible double crush syndrome caused by iatrogenic spinal epidermoid tumor (ET) associated with lumbar puncture as well as concomitant sacral Tarlov cyst in close proximity. She presented with progressive left-sided perianal pain. She had a history of a Caesarean section with lumbar spinal anesthesia. Magnetic resonance imaging (MRI) demonstrated a relatively small intradural extramedullary solid lesion at L5/S1 level and cystic lesion at S2 level. We considered there were two different lesions, such as a tumor and Tarlov cyst; however, we could not rule out the possibility of a single lesion with two different components. Furthermore, there was a distinct compression at more than one locations along the course of the left S2 nerve root and we suspected possible double crush syndrome. We conducted tumor removal and the lesion turned out to be two different pathologies, such as an ET and Tarlov cyst. Both lesions were intraopertively pinching the left S2 nerve root at different sites as expected. The tumor was successfully removed and the cyst wall was imbricated and sutured. We need to take the possibility of ET into consideration if the patient underwent invasive spinal procedure previously. We also have to pay attention to the possibility of double crush syndrome if the nerve root possibly holding the responsibility for symptoms is compressed at two or more sites. This is the first report of possible double crush syndrome caused by acquired spinal tumor and congenital Tarlov cyst.</p>

    DOI: 10.2176/nmccrj.cr.2019-0236

    PubMed

  17. Intraosseous Melanotic Schwannoma in the Sacrum Mimicking Primary Bone Tumor. Reviewed

    Nagashima Y, Nishimura Y, Eguchi K, Awaya T, Yoshikawa S, Haimoto S, Wakabayashi T, Hara M

    NMC case report journal   Vol. 7 ( 3 ) page: 107 - 111   2020.7

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    Authorship:Lead author   Language:English   Publisher:一般社団法人 日本脳神経外科学会  

    <p>Primary tumors of sacrum are rarely seen, and the differential diagnosis is extensive, such as chordomas, giant cell tumors, and schwannomas. Sacral intraosseous schwannomas (IOSs) are very rare and encompass approximately 1%–5% of all spinal schwannomas. Melanotic schwannomas (MSs) are categorized as an unusual variant of benign schwannomas; however, they sometimes follow a malignant course. The authors present a case of MS with intraosseous extension into sacrum in a 48-year-old male arising from the left S2 nerve root. Magnetic resonance imaging (MRI) and computed tomography (CT) scan demonstrated a destructive mass in the sacrum. He was made a diagnosis with MS by 18F-fluoro-deoxy-glucose positron-emission-tomography (<sup>18</sup>F-FDG PET) and open biopsy. The tumor was blackish-colored and vascular-rich fragile tumor covered by fibrous capsule. The floor of the tumor was not encapsulated and invading into the sacral bone. Total removal of the tumor together with the left S2 nerve of origin via posterior approach was achieved. The patient made dramatic recovery of neurological symptoms and tumor recurrence is not seen for 6-month follow-up period. MS is a benign tumor with potential for aggressive behavior and capacity to metastasize. Therefore, total removal of the tumor and careful postoperative follow-up are recommended. Postoperative spinopelvic stability also needs to be taken into consideration. The authors discuss our successful management with a focus on diagnostic process, surgical planning, and histological consideration to provide the most up-to-date guidance on managing this challenging tumor.</p>

    DOI: 10.2176/nmccrj.cr.2019-0238

    PubMed

  18. Postoperative Alignment Changes Following Posterior Fixation for Unstable Thoracolumbar Junction Fractures Complicated with Posterior Ligamentous Complex Injury Reviewed

    Haimoto Shoichi, Nishimura Yusuke, Eguchi Kaoru, Nagashima Yoshitaka, Ando Ryo, Hattori Kazuyoshi, Ginsberg Howard

    Spinal Surgery   Vol. 33 ( 3 ) page: 298 - 301   2019

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    Language:Japanese   Publisher:The Japanese Society of Spinal Surgery  

    DOI: 10.2531/spinalsurg.33.298

  19. Surgical Treatment for Spine Metastasis Reviewed

    Eguchi Kaoru, Nishimura Yusuke, Haimoto Shoichi, Ando Ryo, Nagashima Yoshitaka, Wakabayashi Toshihiko

    Spinal Surgery   Vol. 33 ( 1 ) page: 74 - 77   2019

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    Language:Japanese   Publisher:The Japanese Society of Spinal Surgery  

    DOI: 10.2531/spinalsurg.33.74

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MISC 4

  1. 特集 癒着性くも膜炎の病態と治療法を学ぼう 術後に生じる癒着性くも膜炎

    西村 由介, 永島 吉孝, 齋藤 竜太

    脊椎脊髄ジャーナル   Vol. 35 ( 2 ) page: 99 - 105   2022.6

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    Publisher:三輪書店  

    DOI: 10.11477/mf.5002201799

    CiNii Research

  2. 特集 脊椎脊髄疾患の再手術症例における手術のコツと留意点 頸椎症における再手術

    西村 由介, 永島 吉孝, 齋藤 竜太

    脊椎脊髄ジャーナル   Vol. 34 ( 12 ) page: 896 - 901   2022.3

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    DOI: 10.11477/mf.5002201765

    CiNii Research

  3. 頚椎前方固定術後合併症としての頚椎硬膜外血腫

    粟屋尭之、赤堀翔、永島吉孝

    日本脊髄障害医学会誌   Vol. 34 ( 1 ) page: 66 - 68   2021.3

  4. Clinical study on metastatic spinal tumor with ESCC scale 3

    Brain and Spine   Vol. 1   page: 100425   2021.1

Other research activities 4

  1. 日本脊髄外科指導医

    2022

  2. 脊椎脊髄外科専門医

    2021

  3. 日本脊髄外科認定医

    2020

  4. 日本脳神経外科専門医

    2017

KAKENHI (Grants-in-Aid for Scientific Research) 2

  1. 塩基性ヘリックスループヘリックス転写機構制御と細胞治療を融合する神経再生治療開発

    Grant number:22K09280  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    西村 由介, 永島 吉孝, 夏目 敦至, 古橋 和拡

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    Authorship:Coinvestigator(s) 

    申請者らは『損傷脊髄を完全に再生する驚異的な能力を持つアフリカツメガエル幼生期に強く発現し、脊髄再生に関わるNeurod4などの塩基性ヘリックスループヘリックス(bHLH)神経転写因子を歯髄幹細胞に遺伝子導入してラット脊髄損傷モデルに投与することで、歯髄幹細胞自体をニューロンへ分化させ神経回路を再構築し、神経栄養因子分泌による脊髄再生効果に相加的かつ加速度的な神経機能回復が得られる』という仮説を立て、これを実証する。

  2. 脊髄腫瘍の手術戦略決定に有用な術前、術中H3F3A遺伝子プロファイリング

    Grant number:20K17962  2020.4 - 2023.3

    若手研究

    永島 吉孝

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    脳脊髄腫瘍の診断は、特徴的な病理形態に基づいた診断と特定の遺伝子異常の有無を組み合わせた統合診断が推奨されている。病理形態診断は染色システム等の技術向上により術中迅速診断が可能になっている一方で、迅速遺伝子診断は未だ開発途上であり、実用化されていない。予後が不良であり、かつ神経障害を起こしやすい脊髄腫瘍の手術には術前、術中に腫瘍の性質を十分に把握するための情報が不可欠である。術前、術中にH3F3A変異を同定することで、術後の計画を想定した上で手術戦略を検討できると考え、解析の構築を目指した。

 

Academic Activities 3

  1. Guest editor: DSPN-Neurospine Special Issue "Spine and Spinal Cord Tumors" International contribution

    2021.7 - 2022.3

     More details

    Type:Peer review 

  2. 中部脳神経外科看護セミナー事務局長

    Role(s):Planning, management, etc., Supervision (editorial)

    2019

  3. 日本脊髄外科学会査読委員

    Role(s):Peer review