Language：Japanese   Publisher：Japan Society of Kansei Engineering  

<p>We have been developing a cognitive assessment system based on an electroencephalography (EEG)-based brain-machine interface (BMI) that uses event-related potentials (ERPs) as a virtual “Mind Switch.” ERPs reflect temporal changes in attention and are also known as potential biomarkers for assessing cognitive function. We recorded EEG data from 10 healthy subjects who performed target-selection tasks based upon the visual discrimination of fingerspelling images with or without motor responses (key release). We found differential responses between target and non-target images, which were quantitatively evaluated by the decoding accuracy of the target. We also found that ERPs were enhanced when accompanied by key releases, which might indicate that a more attentive state was involved. These results suggest that fingerspelling images are a feasible tool for cognitive assessment. Future studies should be conducted to demonstrate the applicability of our system in preventing frailty in older people. </p>

DOI： 10.5057/jjske.tjske-d-22-00030

CiNii Research

Language：Japanese   Publisher：Japan Elbow Society  

DOI： 10.24810/jelbow.30.2_402

CiNii Research

Language：English   Publishing type：Research paper (scientific journal)   Publisher：SAGE PUBLICATIONS LTD  

OBJECTIVE: The challenges of an aging population worldwide are the increased number of people needing medical and nursing care and inadequate medical resources. Information and communication technologies have progressed remarkably, leading to innovations in various areas. 5G communication systems are capable of high-capacity, high-speed communication with low latency and are expected to transform medicine. We aimed to report a demonstration experiment of telerehabilitation and telemedicine using a mobile ultrasound system in a depopulated area in a mountainous terrain, where 32% of the population are 65 years or older. METHODS: At the core hospital, a physician or physical therapist remotely performed ultrasonography or rehabilitation on a subject in a clinic. Five general residents participated in the telerehabilitation as subjects. The delay time and video quality transmitted with 5G and long-term evolution (LTE) communication systems were compared. The physician or physical therapist subjectively evaluated the quality and delay of the transmitted images and subject acceptability. RESULTS: Of seven physical therapists, six and three responded that the video quality was "good" for telerehabilitation with 5G/4K resolution and LTE, respectively. Five physical therapists and one physical therapist reported that the delay time was "acceptable" with 5G/4K resolution and LTE, respectively. For telemedicine using a mobile ultrasound system, the responses for 5G were "the delay was acceptable" and "rather acceptable." In contrast, both respondents' responses for LTE were "not acceptable." CONCLUSIONS: Multiple high-definition images can be transmitted with lower latency in telerehabilitation and telemedicine using mobile ultrasound imaging systems with a 5G communication system. These differences affected the subjective evaluation of the doctors and physical therapists.

DOI： 10.1177/20552076221129074

Web of Science

Scopus

PubMed

Language：English  

Although good clinical results have been reported following lunate resection and vascularized os pisiform transfer for advanced stages of Kienböck's disease, the occurrence of wrist osteoarthritis has been highlighted. We aimed to investigate the postoperative condition of the pisiform and the surrounding bones in patients who underwent surgery for advanced stages of Kienböck's disease using magnetic resonance imaging. We retrospectively reviewed the data of six patients (mean age, 45 years; Lichtman stage, IIIb) who underwent lunate resection and vascularized os pisiform transfer for advanced stages of Kienböck's disease and postoperative magnetic resonance imaging examination. We extracted clinical data on pre- and postoperative range of motion, grip strength, wrist pain, Hand20 and Lichtman's criteria, and pre- and postoperative radiographic and magnetic resonance imaging examinations. Bone marrow lesions in the transferred pisiform were found in five patients. Signal changes of bones around the transferred pisiform were found in these five patients; the greatest change was observed in the capitate bone in three patients. These signal changes were found in the opposite parts of the bones around the transferred pisiform. No patient exhibited signal changes in the transferred pisiform bone only. Wrist osteoarthritis after lunate resection and vascularized os pisiform transfer for advanced stages of Kienböck's disease is more likely to be attributed to the low congruency of the transferred pisiform and surrounding bones than to the compromised perfusion of the pisiform. Signal changes in the opposite bone parts around the transferred pisiform were confirmed in all patients with signal changes in the pisiform.

DOI： 10.1016/j.bjps.2022.04.016

Scopus

PubMed

Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI  

Promising treatments for upper motor neuron disease are emerging in which motor function is restored by brain-computer interfaces and functional electrical stimulation. At present, such technologies and procedures are not applicable to lower motor neuron disease. We propose a novel therapeutic strategy for lower motor neuron disease and injury integrating neural stem cell transplantation with our new functional electrical stimulation control system. In a rat sciatic nerve transection model, we transplanted embryonic spinal neural stem cells into the distal stump of the peripheral nerve to reinnervate denervated muscle, and subsequently demonstrated that highly responsive limb movement similar to that of a healthy limb could be attained with a wirelessly powered two-channel neurostimulator that we developed. This unique technology, which can reinnervate and precisely move previously denervated muscles that were unresponsive to electrical stimulation, contributes to improving the condition of patients suffering from intractable diseases of paralysis and traumatic injury.

DOI： 10.3390/ijms23158760

Web of Science

Scopus

PubMed

Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI  

Neural cell transplantation targeting peripheral nerves is a potential treatment regime for denervated muscle atrophy. This study aimed to develop a new therapeutic technique for intractable muscle atrophy by the xenotransplantation of neural stem cells derived from pig fetuses into peripheral nerves. In this study, we created a denervation model using neurotomy in nude rats and transplanted pig-fetus-derived neural stem cells into the cut nerve stump. Three months after transplantation, the survival of neural cells, the number and area of regenerated axons, and the degree of functional recovery by electrical stimulation of peripheral nerves were compared among the gestational ages (E 22, E 27, E 45) of the pigs. Transplanted neural cells were engrafted at all ages. Functional recovery by electric stimulation was observed at age E 22 and E 27. This study shows that the xenotransplantation of fetal porcine neural stem cells can restore denervated muscle function. When combined with medical engineering, this technology can help in developing a new therapy for paralysis.

DOI： 10.3390/ijms23158773

Web of Science

Scopus

PubMed

Language：English   Publishing type：Research paper (scientific journal)  

Eldercare programs such as health consultations and physiotherapy that improve the well-being and extend the life expectancy of people in rural or sparsely populated areas is a socially important though costly problem. We ran a pilot project to test the effectiveness potential of telerehabilitation using markerless motion capture technology integrated in a fast and low-latency IMT-2020 (5G) mobile network. Accelerating technological innovations and the surge in advances of telehealth will greatly impact conventional home visit or outpatient rehabilitation services, working in concert with or even supplanting them, given the potential lower cost and better utilization of time.

DOI： 10.3233/SHTI220291

Scopus

PubMed

Publisher：株式会社医学書院  

DOI： 10.11477/mf.1543208503

CiNii Research

Language：English   Publishing type：Research paper (scientific journal)  

We present a case of remodeling of the diaphyseal diameter of a forearm bone in a child. A 12-year-old boy had a narrow diameter of the radial diaphysis following the removal of a buried plate. The diameter of the radial diaphysis was decreased by half. Osteotomy and internal fixation were performed without graft harvesting from another site of autologous bone. The diameter of radial diaphysis was sufficiently remodeled.

DOI： 10.5604/01.3001.0013.2936

Scopus

PubMed

Language：English   Publishing type：Research paper (scientific journal)   Publisher：IOS PRESS  

BACKGROUND: The upper extremity disability in patients with carpal tunnel syndrome (CTS) is related to dysfunction due to the median nerve damage. However, there is no report on which dysfunctions affect the upper extremity disability. PURPOSE: This study aimed to investigate which clinical factors influence upper extremity disability in women with CTS. METHODS: We analyzed 60 hands of women with bilateral idiopathic CTS. Upper extremity disability was assessed using Hand10, a validated and self-administered tool. Pain intensity was measured using the Japanese version of the Short-Form McGill Pain Questionnaire (SF-MPQ-J). We performed nerve conduction studies, assessed physical and psychological parameters, and collected demographic data. Physical parameters comprised grip strength, pinch strength, tactile threshold, static 2-point discrimination sensation, and severity of numbness. Psychological parameters include depression, pain anxiety, and distress. RESULTS: The bivariate analysis revealed that Hand10 was significantly correlated with age, symptom duration, SF-MPQ-J, grip strength, pain anxiety, and distress. Multiple regression analysis demonstrated that SF-MPQ-J and grip strength were related to Hand10 score. CONCLUSIONS: Pain intensity and grip strength were dysfunctions affecting the upper extremity disability in women with bilateral idiopathic CTS. Rehabilitation approaches for CTS should be considered based on the adaptive activities of the neural networks.

DOI： 10.3233/NRE-182589

Web of Science

Scopus

PubMed

Publisher：南江堂  

DOI： 10.15106/j_seikei69_1322

CiNii Research

Language：English   Publishing type：Research paper (scientific journal)   Publisher：ELSEVIER SCI LTD  

INTRODUCTION: The safety and efficacy of using artificial collagen nerve conduits filled with collagen filaments to treat nerve defects has not been fully studied in humans. We conducted a multicenter, controlled, open-label study to compare the safety and efficacy of artificial nerve conduit grafts with those of autologous nerve grafts. METHODS: We included patients with a sensory nerve defect of ≤30 mm, at the level of the wrist or a more distal location, with the first-line surgical methods selected according to a patient's preference. We compared sensory recovery using static two-point discrimination and adverse events between the artificial collagen nerve conduit and autologous nerve grafting. RESULTS: The artificial nerve conduit group included 49 patients, with a mean age of 42 years and nerve defect of 12.6 mm. The autologous nerve graft group included 7 patients, with historical data of an additional 31 patients, with a mean age of 36 years and nerve defect of 18.7 mm. The rate of recovery of sensory function at 12 months was 75% (36/49) for the artificial nerve conduit group and 73.7% (28/38) in the autologous nerve group. No serious adverse events directly associated with use of the artificial nerve conduit were identified. CONCLUSIONS: The treatment of nerve defects ≤30 mm using artificial collagen nerve conduits was not inferior to treatment using autologous nerve grafts. Based on our data, the new artificial collagen nerve conduit can provide an alternative to autologous nerve for the treatment of peripheral nerve defects.

DOI： 10.1016/j.injury.2018.03.011

Web of Science

Scopus

PubMed

Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

Language：Japanese   Publisher：(一社)日本医療情報学会  

Language：Japanese   Publisher：(一社)日本医療情報学会  

Language：Japanese   Publisher：(一社)日本運動器疼痛学会  

Language：Japanese   Publisher：(株)医学書院  

＜文献概要＞はじめに 新型コロナウイルス感染症の拡大に伴い,PCR(polymerase chain reaction)検査の需要も拡大している.必要とされるPCR検査を実施するには,PCR検査の需要拡大に対応可能な検査体制を確保することが必要である.しかし,普段の診療を行う医療機関において,人的リソースはもとより,PCR検査を実施するスペースの確保と設備の準備は課題である.豊田合成株式会社(以下,豊田合成社)は,新型コロナウイルス感染症の診断や治療に尽力している医療現場を支援する「ココロハコブプロジェクト」の1つとして,新型コロナウイルスのPCR検査車両を2020年6月4日に名古屋大学医学部附属病院(以下,当院)に寄贈した.本PCR検査車両は,豊田合成社からの提案に対し,以前から共同で研究開発を行っている名古屋大学大学院(以下,当大学院)医学系研究科のメンバーらが医療者側の意見を提供するなかで開発された.本稿では,本PCR検査車両の目的と導入背景,現状と今後の展望について記載する.

Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J00421&link_issn=&doc_id=20210914040005&doc_link_id=10.11477%2Fmf.1543208503&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1543208503&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Language：Japanese   Publisher：(一社)日本老年医学会  

Language：Japanese   Publisher：(一社)日本手外科学会  

Language：Japanese   Publisher：(一社)日本手外科学会  

Language：Japanese   Publisher：(一社)日本手外科学会  

Language：Japanese   Publisher：(公社)日本整形外科学会  

Language：Japanese   Publisher：(公社)日本整形外科学会  

Language：Japanese   Publisher：日本肘関節学会  

Language：Japanese   Publisher：日本末梢神経学会  

Language：Japanese   Publisher：日本末梢神経学会  

Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

Language：Japanese   Publisher：日本末梢神経学会  

神経内ガングリオンは、末梢神経の外側上膜内に嚢胞性腫瘤を形成し、末梢神経障害の原因となる。尺骨神経内ガングリオンを伴った肘部管症候群の2例について治療成績を報告する。2症例とも右尺骨神経麻痺で当院を紹介受診した。術前エコーとMRI検査にて尺骨神経内に嚢胞性腫瘤を伴っていた。神経内ガングリオンを伴った肘部管症候群と診断し、尺骨神経の皮下前方移動術をおこなった。神経内剥離やガングリオン摘出術をおこなっていないが、術後それぞれ6年6ヵ月と3年1ヵ月の時点で、エコーやMRI検査において神経内ガングリオンの再発を認めていない。(著者抄録)

Language：Japanese   Publisher：(一社)日本手外科学会  

Language：Japanese   Publisher：日本末梢神経学会  

Language：Japanese   Publisher：日本末梢神経学会  

Language：Japanese   Publisher：東海整形外科外傷研究会  

Language：Japanese   Publisher：(公社)日本整形外科学会  

Language：Japanese   Publisher：(一社)日本手外科学会  

Language：Japanese   Publisher：(株)南江堂  

Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00764&link_issn=&doc_id=20181129350008&doc_link_id=10.15106%2Fj_seikei69_1322&url=https%3A%2F%2Fdoi.org%2F10.15106%2Fj_seikei69_1322&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Language：Japanese   Publisher：日本末梢神経学会  

筋組織は神経細胞とのinteractionを失うと、脱神経筋内でアセチルコリン受容体の脱凝集といった神経筋接合部の形態変化が起こる。末梢神経を損傷して長期間たった脱神経筋は神経再生に対してnon-permissiveな状態となり、神経修復術をおこなっても十分に運動機能が回復しない。脱神経筋の神経筋接合部を治療ターゲットとした末梢神経損傷治療の研究について文献的考察を交え報告する。(著者抄録)

Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J03411&link_issn=&doc_id=20190117120015&doc_link_id=%2Fet2perip%2F2018%2F002902%2F016%2F0166-0168%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fet2perip%2F2018%2F002902%2F016%2F0166-0168%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(公社)日本整形外科学会  

Language：Japanese   Publisher：(公社)日本整形外科学会  

Language：Japanese   Publisher：(一社)日本手外科学会  

Language：Japanese   Publisher：(一社)日本手外科学会  

Language：Japanese   Publisher：(一社)日本マイクロサージャリー学会  

Language：Japanese   Publisher：日本末梢神経学会  

Language：Japanese   Publisher：日本末梢神経学会  

Language：Japanese   Publisher：(一社)日本手外科学会  

Language：Japanese   Publisher：(一社)日本手外科学会  

Language：Japanese   Publisher：(一社)日本手外科学会  

Event date： 2023.11

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

Venue：グランドプリンスホテル新高輪　国際館パミール（   Country：Japan  

Event date： 2023.10

Venue：名古屋  

Event date： 2021.1

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：Web形式   Country：Japan  

Language：Japanese   Presentation type：Oral presentation (invited, special)