Updated on 2023/04/14

写真a

 
AMAIKE Kazuma
 
Organization
Research Center for Materials Science Assistant Professor
Graduate School
Graduate School of Science
Title
Assistant Professor
External link

Degree 1

  1. 博士(理学) ( 2016.3   名古屋大学 ) 

 

Papers 20

  1. Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes

    Nonaka Hiroshi, Mino Takeharu, Sakamoto Seiji, Oh Jae Hoon, Watanabe Yu, Ishikawa Mamoru, Tsushima Akihiro, Amaike Kazuma, Kiyonaka Shigeki, Tamura Tomonori, Radu Aricescu A., Kakegawa Wataru, Miura Eriko, Yuzaki Michisuke, Hamachi Itaru

    Chem   Vol. 9 ( 2 ) page: 523 - 540   2023.2

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    Language:English  

    Various small molecules have been used as functional probes for tissue imaging in medical diagnosis and pharmaceutical drugs for disease treatment. The spatial distribution, target selectivity, and diffusion/excretion kinetics of small molecules in structurally complicated specimens are critical for function. However, robust methods for precisely evaluating these parameters in the brain have been limited. Herein, we report a new method termed “fixation-driven chemical cross-linking of exogenous ligands (FixEL), ” which traps and images exogenously administered molecules of interest (MOIs) in complex tissues. This method relies on protein-MOI interactions and chemical cross-linking of amine-tethered MOI with paraformaldehyde used for perfusion fixation. FixEL is used to obtain images of the distribution of the small molecules, which addresses selective/nonselective binding to proteins, time-dependent localization changes, and diffusion/retention kinetics of MOIs such as the scaffold of PET tracer derivatives or drug-like small molecules.

    CiNii Research

  2. Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes

    Nonaka H., Mino T., Sakamoto S., Oh J.H., Watanabe Y., Ishikawa M., Tsushima A., Amaike K., Kiyonaka S., Tamura T., Radu Aricescu A., Kakegawa W., Miura E., Yuzaki M., Hamachi I.

    Chem   Vol. 9 ( 2 ) page: 523 - 540   2023.2

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    Publisher:Chem  

    Various small molecules have been used as functional probes for tissue imaging in medical diagnosis and pharmaceutical drugs for disease treatment. The spatial distribution, target selectivity, and diffusion/excretion kinetics of small molecules in structurally complicated specimens are critical for function. However, robust methods for precisely evaluating these parameters in the brain have been limited. Herein, we report a new method termed “fixation-driven chemical cross-linking of exogenous ligands (FixEL),” which traps and images exogenously administered molecules of interest (MOIs) in complex tissues. This method relies on protein-MOI interactions and chemical cross-linking of amine-tethered MOI with paraformaldehyde used for perfusion fixation. FixEL is used to obtain images of the distribution of the small molecules, which addresses selective/nonselective binding to proteins, time-dependent localization changes, and diffusion/retention kinetics of MOIs such as the scaffold of PET tracer derivatives or drug-like small molecules.

    DOI: 10.1016/j.chempr.2022.11.005

    Scopus

  3. Discovery of 2,6-Dihalopurines as Stomata Opening Inhibitors: Implication of an LRX-Mediated H plus -ATPase Phosphorylation Pathway

    Ueda Ayaka, Aihara Yusuke, Sato Shinya, Kano Keiko, Mishiro-Sato Emi, Kitano Hiroyuki, Sato Ayato, Fujimoto Kazuhiro J., Yanai Takeshi, Amaike Kazuma, Kinoshita Toshinori, Itami Kenichiro

    ACS CHEMICAL BIOLOGY   Vol. 18 ( 2 ) page: 347 - 355   2023.1

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    Language:English   Publisher:ACS Chemical Biology  

    Stomata are pores in the leaf epidermis of plants and their opening and closing regulate gas exchange and water transpiration. Stomatal movements play key roles in both plant growth and stress responses. In recent years, small molecules regulating stomatal movements have been used as a powerful tool in mechanistic studies, as well as key players for agricultural applications. Therefore, the development of new molecules regulating stomatal movement and the elucidation of their mechanisms have attracted much attention. We herein describe the discovery of 2,6-dihalopurines, AUs, as a new stomatal opening inhibitor, and their mechanistic study. Based on biological assays, AUs may involve in the pathway related with plasma membrane H+-ATPase phosphorylation. In addition, we identified leucine-rich repeat extensin proteins (LRXs), LRX3, LRX4 and LRX5 as well as RALF, as target protein candidates of AUs by affinity based pull down assay and molecular dynamics simulation. The mechanism of stomatal movement related with the LRXs-RALF is an unexplored pathway, and therefore further studies may lead to the discovery of new signaling pathways and regulatory factors in the stomatal movement.

    DOI: 10.1021/acschembio.2c00771

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  4. C-H arylation enables synthesis of imidazole-4-carboxamide (ICA) based fairy chemicals with plant growth promoting activity

    Ayaka Ueda, Kazuma Amaike, Yoko Shirotani, Robin Warstat, Hideto Ito, Jae-Hoon Choi, Hirokazu Kawagishi, Kenichiro Itami

    Canadian Journal of Chemistry     2022.12

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    Publishing type:Research paper (scientific journal)   Publisher:Canadian Science Publishing  

    Imidazole-4-carboxamide (ICA), which is one of a group of “fairy chemicals” (FCs) that cause the fairy ring phenomena, has plant growth inhibitory activity. FCs have the potential as candidates for a new family of plant hormones as they have been found endogenously in all plant species tested, and show growth-regulating activity against the plants. While basic research on FCs is progressing, they are also expected to be applied not only to agrochemicals but also as pharmaceuticals. Derivatization of one of FCs, 2-azahypoxanthine (AHX) and the structure-activity relationship (SAR) studies have clarified its activity as a plant growth promoter. Yet, imidazole-4-carboxamide (ICA) has not been derivatized at all and SAR regarding its activity remains unknown. In this study, we synthesized the derivatives of ICA by direct C-H arylation of ICA precursors and evaluated its activity in rice. The 12 total compounds including the arylated ICAs and their precursors were evaluated for root and shoot elongation in rice, resulting in the discovery that a number of compounds unexpectedly have an elongation activity in the root and shoot.

    DOI: 10.1139/cjc-2022-0256

  5. Synthesis, properties, and material hybridization of bare aromatic polymers enabled by dendrimer support

    Fujiki Shusei, Amaike Kazuma, Yagi Akiko, Itami Kenichiro

    NATURE COMMUNICATIONS   Vol. 13 ( 1 ) page: 5358   2022.9

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    Language:Japanese   Publisher:Nature Communications  

    Aromatic polymers are the first-choice platform for current organic materials due to their distinct optical, electronic, and mechanical properties as well as their biocompatibility. However, bare aromatic polymer backbones tend to strongly aggregate, rendering them essentially insoluble in organic solvent. While the typical solution is to install many solubilizing substituents on the backbones, this often provokes undesired property changes. Herein, we report the synthesis of bare aromatic polymers enabled by a dendrimer support. An initiator arene containing a diterpenoid-based dendrimer undergoes Pd-catalyzed polymerization with monomers bearing no solubilizing substituents to furnish bare aromatic polymers such as polythiophenes and poly(para-phenylene)s. The high solubility of dendrimer-ligated polymers allows not only the unveiling of the properties of unsubstituted π-conjugated backbone, but also mild release of dendrimer-free aromatic polymers and even transfer of aromatic polymers to other materials, such as silica gel and protein, which may accelerate the creation of hybrid materials nowadays challenging to access.

    DOI: 10.1038/s41467-022-33100-7

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  6. Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock

    Kolarski, Dusan, Miller, Simon, Oshima, Tsuyoshi, Nagai, Yoshiko, Aoki, Yugo, Kobauri, Piermichele, Srivastava, Ashutosh, Sugiyama, Akiko, Amaike, Kazuma, Sato, Ayato, Tama, Florence, Szymanski, Wiktor, Feringa, Ben L., Itami, Kenichiro, Hirota, Tsuyoshi

    Journal of the American Chemical Society   Vol. 143 ( 4 ) page: 2078 - 2087   2021.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/jacs.0c12280

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  7. An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals

    Miller, Simon, Aikawa, Yoshiki, Sugiyama, Akiko, Nagai, Yoshiko, Hara, Aya, Oshima, Tsuyoshi, Amaike, Kazuma, Kay, Steve A., Itami, Kenichiro, Hirota, Tsuyoshi

    Cell Chemical Biology   Vol. 27 ( 9 ) page: 1192 - +   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.chembiol.2020.05.008

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  8. Small Molecules Modulating Mammalian Biological Clocks: Exciting New Opportunities for Synthetic Chemistry

    Amaike, Kazuma, Oshima, Tsuyoshi, Skoulding, Nicola Stephanie, Toyama, Yoshifumi, Hirota, Tsuyoshi, Itami, Kenichiro

    Chem   Vol. 6 ( 9 ) page: 2186 - 2198   2020.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.chempr.2020.08.011

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  9. Construction of a Fluorescent Screening System of Allosteric Modulators for the GABA(A) Receptor Using a Turn-On Probe Reviewed

    Sakamoto, Seiji, Sakamoto, Seiji, Yamaura, Kei, Yamaura, Kei, Numata, Tomohiro, Numata, Tomohiro, Harada, Fumio, Harada, Fumio, Amaike, Kazuma, Amaike, Kazuma, Inoue, Ryuji, Inoue, Ryuji, Kiyonaka, Shigeki, Kiyonaka, Shigeki, Hamachi, Itaru, Hamachi, Itaru

    ACS Central Science   Vol. 5 ( 9 ) page: 1541 - 1553   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. The fast inhibitory actions of GABA are mainly mediated by GABA(A) receptors (GABA(A)Rs), which are widely recognized as clinically relevant drug targets. However, it remains difficult to create screening systems for drug candidates that act on GABA A Rs because of the existence of multiple ligand-binding sites and the delicate pentameric structures of GABA(A)Rs. We here developed the first turn-on fluorescent imaging probe for GABA(A)Rs, which can be used to quantitatively evaluate ligand-receptor interactions under live cell conditions. Using noncovalent labeling of GABA(A)Rs with this turn-on probe, a new imaging-based ligand assay system, which allows discovery of positive allosteric modulators (PAMs) for the GABA(A)R, was successfully constructed. Our system is applicable to high-throughput ligand screening, and we discovered new small molecules that function as PAMs for GABA(A)Rs. These results highlight the power of the use of a turn-on fluorescent probe to screen drugs for complicated membrane proteins that cannot be addressed by conventional methods.

    DOI: 10.1021/acscentsci.9b00539

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  10. Synthesis of multiply arylated pyridines Reviewed

    Asako, Takashi, Hayashi, Wakana, Amaike, Kazuma, Suzuki, Shin, Itami, Kenichiro, Muto, Kei, Yamaguchi, Junichiro

    Tetrahedron   Vol. 73 ( 26 ) page: 3669 - 3676   2017.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    We have achieved a synthesis of multiply arylated pyridines by using a [4 + 2] cycloaddition of 2,4-diaryl-5-chloroxazoles and cinnamic acids as a key reaction. The resulting hydroxytriarylpyridines can be derivatized into triarylpyridines, tetraarylpyridines and pentaarylpyridines by sequential cross couplings. This synthetic method allows for facile and rapid access to highly arylated pyridines with different aryl substituents. (C) 2017 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.tet.2017.03.095

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  11. Affinity-Guided Oxime Chemistry for Selective Protein Acylation in Live Tissue Systems Reviewed

    Tamura, Tomonori, Song, Zhining, Amaike, Kazuma, Lee, Shin, Yin, Sifei, Kiyonaka, Shigeki, Hamachi, Itaru

    Journal of the American Chemical Society   Vol. 139 ( 40 ) page: 14181 - 14191   2017

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    Catalyst-mediated protein modification is a powerful approach for the imaging and engineering of natural proteins. We have previously developed affinity-guided 4-dimethylaminopyridine (AGD) chemistry as an efficient protein modification method using a catalytic acyl transfer reaction. However, because of the high electrophilicity of the thioester acyl donor molecule, AGD chemistry suffers from nonspecific reactions to proteins other than the target protein in crude biological environments, such as cell lysates, live cells, and tissue samples. To overcome this shortcoming, we here report a new acyl donor/organocatalyst system that allows more specific and efficient protein modification. In this method, a highly nucleophilic pyridinium oxime (PyOx) catalyst is conjugated to a ligand specific to the target protein. The ligand-tethered PyOx selectively binds to the target protein and facilitates the acyl transfer reaction of a mild electrophilic N-acyl-N-alkylsulfonamide acyl donor on the protein surface. We demonstrated that the new catalytic system, called AGOX (affinity-guided oxime) chemistry, can modify target proteins, both in test tubes and cell lysates, more selectively and efficiently than AGD chemistry. Low-background fluorescence labeling of the endogenous cell-membrane proteins, carbonic anhydrase XII and the folate receptor, in live cells allowed for the precise quantification of diffusion coefficients in the protein's native environment. Furthermore, the excellent biocompatibility and bioorthogonality of AGOX chemistry were demonstrated by the selective labeling of an endogenous neurotransmitter receptor in mouse brain slices, which are highly complicated tissue samples.

    DOI: 10.1021/JACS.7B07339

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  12. Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding in live cells Reviewed

    Amaike, Kazuma, Tamura, Tomonori, Hamachi, Itaru

    Chemical Communications   Vol. 53 ( 88 ) page: 11972 - 11983   2017

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ROYAL SOC CHEMISTRY  

    Endogenous protein labeling is one of the most invaluable methods for studying the bona fide functions of proteins in live cells. However, multi-molecular crowding conditions, such as those that occur in live cells, hamper the highly selective chemical labeling of a protein of interest (POI). We herein describe how the efficient coupling of molecular recognition with a chemical reaction is crucial for selective protein labeling. Recognition-driven protein labeling is carried out by a synthetic labeling reagent containing a protein (recognition) ligand, a reporter tag, and a reactive moiety. The molecular recognition of a POI can be used to greatly enhance the reaction kinetics and protein selectivity, even under live cell conditions. In this review, we also briefly discuss how such selective chemical labeling of an endogenous protein can have a variety of applications at the interface of chemistry and biology.

    DOI: 10.1039/C7CC07177A

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  13. Synthesis of Triarylpyridines in Thiopeptide Antibiotics by Using a C-H Arylation/Ring-Transformation Strategy Reviewed

    Amaike, Kazuma, Itami, Kenichiro, Yamaguchi, Junichiro

    Chemistry - A European Journal   Vol. 22 ( 13 ) page: 4384 - 4388   2016.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:WILEY-V C H VERLAG GMBH  

    We have described a C-H arylation/ring-transformation strategy for the synthesis of triarylpyridines, which form the core structure of thiopeptide antibiotics. This synthetic method readily gave 2,3,6-triarylpyridines in a regioselective manner by a two-phase approach: C-H arylation (a nickel-catalyzed decarbonylative Suzuki-Miyaura cross-coupling and decarbonylative C-H coupling for the synthesis of 2,4-diaryloxazoles) and ring transformation ([4+2] cycloaddition of 2,4-diaryloxazoles with (hetero)arylacrylic acids). To showcase these methods, we have accomplished the formal synthesis of thiopeptide antibiotics GE2270s and amythiamicins.

    DOI: 10.1002/chem.201600351

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  14. Direct C7 Functionalization of Tryptophan. Synthesis of Methyl (S)-2-((tert-Butoxycarbonyl) amino)-3-(7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-3-yl)propanoate Reviewed

    Amaike, Kazuma, Loach, Richard P., Movassaghi, Mohammad

    Organic Syntheses   Vol. 92   page: 373 - +   2015

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    DOI: 10.15227/ORGSYN.092.0373

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  15. beta-Selective C-H Arylation of Pyrroles Leading to Concise Syntheses of Lamellarins C and I Reviewed

    Ueda, Kirika, Amaike, Kazuma, Maceiczyk, Richard M., Itami, Kenichiro, Yamaguchi, Junichiro

    Journal of the American Chemical Society   Vol. 136 ( 38 ) page: 13226 - 13232   2014.9

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    The first general beta-selective C-H arylation of pyrroles has been developed by using a rhodium catalyst. This C H arylation reaction, which is retrosynthetically straightforward but results in unusual regioselectivity, could result in de novo syntheses of pyrrole-derived natural products and pharmaceuticals. As such, we have successfully synthesized polycyclic marine pyrrole alkaloids, lamellarins C and I, by using this beta-selective arylation of pyrroles with aryl iodides (C-H/C-I coupling) and a new double C-H/C-H coupling as key steps.

    DOI: 10.1021/ja508449y

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  16. Late-Stage C-H Coupling Enables Rapid Identification of HDAC Inhibitors: Synthesis and Evaluation of NCH-31 Analogues Reviewed

    Sekizawa, Hiromi, Amaike, Kazuma, Itoh, Yukihiro, Suzuki, Takayoshi, Itami, Kenichiro, Yamaguchi, Junichiro

    ACS Medicinal Chemistry Letters   Vol. 5 ( 5 ) page: 582 - 586   2014.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    We previously reported the discovery of NCH-31, a potent histone deacetylase (HDAC) inhibitor. By utilizing our C-H coupling reaction, we rapidly synthesized 16 analogues (IYS-1 through IYS-15 and IYS-Me) of NCH-31 with different aryl groups at the C4-position of 2-aminothiazole core of NCH-31. Subsequent biological testing of these derivatives revealed that 3-fluorophenyl (IYS-10) and 4-fluorophenyl (IYS-15) derivatives act as potent pan-HDAC inhibitor. Additionally, 4-methylphenyl (IYS-1) and 3-fluoro-4-methylphenyl (IYS-14) derivatives acted as HDAC6-insensitive inhibitors. The present work clearly shows the power of the late-stage C H coupling approach to rapidly identify novel and highly active/selective biofunctional molecules.

    DOI: 10.1021/ml500024s

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  17. C7-Derivatization of C3-Alkylindoles Including Tryptophans and Tryptamines Reviewed

    Loach, Richard P., Fenton, Owen S., Amaike, Kazuma, Siegel, Dustin S., Ozkal, Erhan, Movassaghi, Mohammad

    The Journal of Organic Chemistry   Vol. 79 ( 22 ) page: 11254 - 11263   2014

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    A versatile strategy for C7-selective boronation of tryptophans, tryptamines, and 3-alkylindoles by way of a single-pot C2/C7-diboronationC2-protodeboronation sequence is described. The combination of a mild iridium-catalyzed C2/C7-diboronation followed by an in situ palladium-catalyzed C2-protodeboronation allows efficient entry to valuable C7-boroindoles that enable further C7-derivatization. The versatility of the chemistry is highlighted by the gram-scale synthesis of C7-boronated N-Boc-L-tryptophan methyl ester and the rapid synthesis of C7-halo, C7-hydroxy, and C7-aryl tryptophan derivatives.

    DOI: 10.1021/JO502062Z

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  18. Nickel-Catalyzed Direct Coupling of Heteroarenes

    Yamaguchi Junichiro, Muto Kei, Amaike Kazuma, Yamamoto Takuya, Itami Kenichiro

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   Vol. 71 ( 6 ) page: 576 - 587   2013.6

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    Language:Japanese  

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  19. Nickel-Catalyzed Direct Coupling of Heteroarenes Reviewed

    Yamaguchi, Junichiro, Muto, Kei, Amaike, Kazuma, Yamamoto, Takuya, Itami, Kenichiro

    Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry   Vol. 71 ( 6 ) page: 576 - 587   2013

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:SOC SYNTHETIC ORGANIC CHEM JPN  

    Nickel-catalyzed cross-coupling reactions have recently been receiving significant attention from the synthetic community as a way to construct carbon-carbon or carbon-heteroatom bonds, because nickel catalysts are less expensive and less toxic than palladium catalysts.We herein describe our recent developments in nickel-catalyzed biaryl coupling methodology, along with mechanistic studies and applications to the synthesis of natural products and pharmaceuticals. In particular, we focus on nickel-catalyzed direct coupling reactions in which "unreactive" bonds such as C-H, C-O, and C-C bonds are converted into biaryl moieties.

    DOI: 10.5059/YUKIGOSEIKYOKAISHI.71.576

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    CiNii Research

  20. Decarbonylative C-H Coupling of Azoles and Aryl Esters: Unprecedented Nickel Catalysis and Application to the Synthesis of Muscoride A Reviewed

    Amaike, Kazuma, Muto, Kei, Yamaguchi, Junichiro, Itami, Kenichiro

    Journal of the American Chemical Society   Vol. 134 ( 33 ) page: 13573 - 13576   2012.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:AMER CHEMICAL SOC  

    A nickel-catalyzed decarbonylative C-H biaryl coupling of azoles and aryl esters is described. The newly developed catalytic system does not require the use of expensive metal catalysts or silver- or copper-based stoichiometric oxidants. We have successfully applied this new C-H arylation reaction to a convergent formal synthesis of muscoride A.

    DOI: 10.1021/ja306062c

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MISC 1

  1. Synthesis of Natural Products and Pharmaceuticals via Catalytic C-H Functionalization

    Junichiro Yamaguchi, Kazuma Amaike, Kenichiro Itami

    Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation     page: 505 - 550   2016.1

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    Language:English   Publisher:wiley  

    The synthesis of natural products and pharmaceuticals, particularly those containing heterocyclic frameworks, can be dramatically simplified by using catalytic C-H functionalization. C-H functionalization has gathered significant interest from the organic synthesis community because it provides a new strategy to construct carbon-carbon and carbon-heteroatom bonds in highly functionalized, complex molecules without prefunctionalization. In this book chapter, methods in heterocycle substitution and synthesis using catalytic C-H functionalization are classified by heterocycle, with specific focus on the cutting-edge synthesis of natural products and pharmaceuticals.

    DOI: 10.1002/9783527691920.ch16

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 核酸輸送を加速させる一次元伸張ナノカーボン分子の創製

    Grant number:22K14797  2022.4 - 2024.3

    科学研究費助成事業  若手研究

    天池 一真

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    核酸輸送はDNAやRNAを外部から宿主細胞に導入することであり、創薬や育種の現場から基礎生物学に至るまで生命科学研究に絶対的に不可欠な技術である。生命現象の理解と制御のさらなる高度化が必要な今、効率や選択性はもちろんのこと生体直交性などの多様な機能が核酸輸送に求められている。核酸輸送の分野に全く新しい方法、キャリア分子群の登場がまたれる所以である。本研究では、哺乳・植物・昆虫を対象とした核酸輸送を加速させるテーラーメイドな核酸輸送ナノカーボン分子を創製することで基礎と応用の両面からこの分野に非線形のブレークスルーをもたらす。

  2. Search and design of compounds with synergistic effects by AI

    Grant number:20H05797  2020.10 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Transformative Research Areas (B)

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    Authorship:Coinvestigator(s) 

  3. Science of fairy chemicals and their application development

    Grant number:20H05620  2020.7 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Specially Promoted Research

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    Authorship:Coinvestigator(s)