Updated on 2024/02/29

写真a

 
TANAHASHI Kana
 
Organization
Graduate School of Medicine Program in Integrated Medicine Biomedical Regulation Lecturer
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Lecturer

Degree 1

  1. Ph. D. ( 2015.3   Nagoya University ) 

Research Interests 4

  1. 先天性乏毛症

  2. 遺伝性皮膚疾患

  3. 角化症

  4. 皮膚科学

Research Areas 2

  1. Life Science / Dermatology

  2. Life Science / Dermatology

Research History 2

  1. Nagoya University   Nagoya University Hospital Dermatology   Assistant Professor

    2019.5

  2. 名古屋大学医学部附属病院   皮膚科   助教

    2019.5

Professional Memberships 1

  1. 日本皮膚科学会

    2007

Committee Memberships 1

  1. 日本研究皮膚科学会   評議員  

    2015   

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    Committee type:Academic society

 

Papers 47

  1. Generalized Verrucosis on a Background of 3C Syndrome Treated With Subcutaneous IgG Supplementation

    Fukaura, R; Terashima-Murase, C; Tanahashi, K; Sato, Y; Kawase, M; Kato, K; Akiyama, M

    JAMA DERMATOLOGY   Vol. 159 ( 12 ) page: 1397 - 1399   2023.12

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    Language:English   Publisher:JAMA Dermatology  

    DOI: 10.1001/jamadermatol.2023.3801

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  2. Ceramide analysis in combination with genetic testing may provide a precise diagnosis for self-healing collodion babies.

    Takeichi T, Ohno Y, Tanahashi K, Ito Y, Shiraishi K, Utsunomiya R, Yoshida S, Ikeda K, Nomura H, Morizane S, Sayama K, Ogi T, Muro Y, Kihara A, Akiyama M

    Journal of lipid research     page: 100308   2022.11

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    Language:English  

    DOI: 10.1016/j.jlr.2022.100308

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  3. Whole-exome sequencing reveals a retinitis pigmentosa-causative PRPH2 variant as a secondary finding in a patient with pseudoxanthoma elasticum

    Miyazaki Akira, Takeichi Takuya, Tanahashi Kana, Taki Tomoki, Taki Yosuke, Muro Yoshinao, Akiyama Masashi

    JOURNAL OF DERMATOLOGY     2022.10

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    Language:Japanese   Publisher:Journal of Dermatology  

    DOI: 10.1111/1346-8138.16618

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  4. Case of ichthyosis with confetti caused by KRT10 mutation, complicated with multiple malignant melanomas

    Ito Yasutoshi, Takeichi Takuya, Nakagawa Koichi, Tanahashi Kana, Muro Yoshinao, Ogi Tomoo, Akiyama Masashi

    JOURNAL OF DERMATOLOGY     2022.3

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    Language:Japanese   Publisher:Journal of Dermatology  

    DOI: 10.1111/1346-8138.16348

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  5. Autoinflammatory Keratinization Disease With Hepatitis and Autism Reveals Roles for JAK1 Kinase Hyperactivity in Autoinflammation

    Takeichi Takuya, Lee John Y. W., Okuno Yusuke, Miyasaka Yuki, Murase Yuya, Yoshikawa Takenori, Tanahashi Kana, Nishida Emi, Okamoto Tatsuya, Ito Komei, Muro Yoshinao, Sugiura Kazumitsu, Ohno Tamio, McGrath John A., Akiyama Masashi

    FRONTIERS IN IMMUNOLOGY   Vol. 12   page: 737747   2022.1

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    Language:Japanese   Publisher:Frontiers in Immunology  

    Heterozygous mutations in JAK1 which result in JAK-STAT hyperactivity have been implicated in an autosomal dominant disorder that features multi-organ immune dysregulation. This study identifies another previously unreported heterozygous missense JAK1 mutation, H596D, in an individual with a unique autoinflammatory keratinization disease associated with early-onset liver dysfunction and autism. Using CRISPR-Cas9 gene targeting, we generated mice with an identical Jak1 knock-in missense mutation (Jak1H595D/+;I596I/+;Y597Y/+ mice) that recapitulated key aspects of the human phenotype. RNA sequencing of samples isolated from the Jak1H595D/+;I596I/+;Y597Y/+ mice revealed the upregulation of genes associated with the hyperactivation of tyrosine kinases and NF-κB signaling. Interestingly, there was a strong correlation between genes downregulated in Jak1H595D/+;I596I/+;Y597Y/+ mice and those downregulated in the brain of model mice with 22q11.2 deletion syndrome that showed cognitive and behavioral deficits, such as autism spectrum disorders. Our findings expand the phenotypic spectrum of JAK1-associated disease and underscore how JAK1 dysfunction contributes to this autoinflammatory disorder.

    DOI: 10.3389/fimmu.2021.737747

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  6. Mutations in SAM syndrome and palmoplantar keratoderma patients suggest genotype/phenotype correlations in DSG1 mutations.

    Takeuchi S, Takeichi T, Koike Y, Takama H, Tanahashi K, Okuno Y, Ishii N, Muro Y, Ogi T, Suga Y, Akiyama M

    Journal of the European Academy of Dermatology and Venereology : JEADV     2021.10

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    Language:English  

    DOI: 10.1111/jdv.17752

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  7. Cross-sectional nationwide epidemiologic survey on quality of life and treatment efficacy in Japanese patients with congenital ichthyoses. International journal

    Yuika Suzuki, Kana Tanahashi, Chiaki Terashima-Murase, Takuya Takeichi, Yumiko Kobayashi, Fumie Kinoshita, Masashi Akiyama

    Journal of dermatological science   Vol. 113 ( 1 ) page: 2 - 9   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Congenital ichthyoses sometimes present with severe skin symptoms that significantly affect the patient's quality of life (QOL). Symptomatic treatments are the mainstay therapies, and their efficacy is limited and inadequate. OBJECTIVE: To assess the disease severity and QOL in patients with congenital ichthyoses, and to investigate the effectiveness of current treatments. METHODS: We conducted a questionnaire-based Japan-wide epidemiological survey of patients with congenital ichthyosis who received medical care from 1 January 2016-31 December 2020. Effectiveness of past and current treatments was assessed. The outcomes were the physician's assessment, disease severity assessed using the clinical ichthyosis score (CIS), and the disease burden estimated using the Dermatology Life Quality Index (DLQI), the Children's Dermatology Life Quality Index (CDLQI), and the Infants' Dermatitis Quality of Life Index. RESULTS: One hundred patients with 14 ichthyosis subtypes from 47 institutes were included in the final analysis. The CDLQI score showed a positive correlation with CIS (rs = 0.59, p = 0.004), while the DLQI score showed no significant correlation (rs = 0.13, p = 0.33). All existing medications were effective for many patients. Etretinate improved QOL and reduced CIS, but side effects including bone growth retardation were reported. Decreased treatment willingness was observed in patients with very low and very high CIS. CONCLUSION: QOL scores were found to correlate with CIS in children, but not in adults. Considering the adverse events, it is speculated that etretinate is not indicated for children with mild cases. Petrolatum was the most commonly used medication, even in patients who were reluctant to receive treatment.

    DOI: 10.1016/j.jdermsci.2023.11.002

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  8. Diagnosis of acute generalized pustular bacterid facilitated by point-of-care testing. International journal

    Ryo Fukaura, Chiaki Terashima-Murase, Kana Tanahashi, Takuya Takeichi, Masashi Akiyama

    The Journal of dermatology   Vol. 50 ( 10 ) page: E347 - E348   2023.10

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  9. Allergen-specific IgG4 increase in atopic dermatitis with long-term dupilumab use. International journal

    Mariko Ogawa-Momohara, Yoshinao Muro, Chiaki Murase, Tomoki Taki, Kana Tanahashi, Yuta Yamashita, Haruka Koizumi, Ryo Fukaura, Takuya Takeichi, Masashi Akiyama

    The British journal of dermatology   Vol. 189 ( 4 ) page: 472 - 474   2023.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/bjd/ljad207

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  10. 老人性乾皮症の病態におけるSDR9C7の果たす役割の解明

    武市 拓也, 棚橋 華奈, 秋山 真志

    加齢皮膚医学セミナー   Vol. 17 ( 2 ) page: 15 - 19   2022.12

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    Language:Japanese   Publisher:加齢皮膚医学研究会  

    老人性乾皮症は、皮脂および汗の分泌が減退し、皮膚が乾燥して光沢を失い粗造になった状態をいう。皮膚バリア機能の低下のため冬季では湿疹性病変を合併し、強いそう痒を伴うことがある。本研究では、老人性乾皮症ならびにアトピー性皮膚炎と診断された、既知のFLG遺伝子変異を有しない10名の患者の血液からDNAを抽出し、whole-exome sequence解析法を用いて、SDR9C7遺伝子のバリアント解析、SNP解析を行った。今回解析を行った老人性乾皮症ならびにアトピー性皮膚炎患者の10名の中には、SDR9C7遺伝子の変異/バリアントを有する症例は同定されなかった。本研究では、老人性乾皮症におけるSDR9C7分子の病態への関与は明らかにならなかった。今後、解析症例数を増やすことを検討している。(著者抄録)

  11. Deep Phenotyping of Superficial Epidermolytic Ichthyosis due to a Recurrent Mutation in KRT2. International journal

    Yuika Suzuki, Takuya Takeichi, Kana Tanahashi, Yoshinao Muro, Yasushi Suga, Tomoo Ogi, Masashi Akiyama

    International journal of molecular sciences   Vol. 23 ( 14 )   2022.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Superficial epidermolytic ichthyosis (SEI) is an autosomal dominant inherited ichthyosis. SEI is caused by mutations in KRT2 and frequently shows erythroderma and widespread blistering at birth. We report the clinical manifestations of two patients from a Japanese family with SEI caused by a hotspot mutation, p.Glu487Lys, in KRT2. In addition, we summarize previous reports on SEI patients with the identical mutation. One of the two patients had disease onset at the age of 7 months. The other patient's age of onset is unknown, but it was in childhood. Neither of the two patients showed erythroderma. To perform deep phenotyping, we studied the age of onset and the frequency of erythroderma in 34 reported SEI cases with the p.Glu487Lys mutation, including the present cases. Among the cases with sufficient clinical information, 44.4% of the cases that were due to p.Glu487Lys in KRT2 occurred at birth. Erythroderma was observed in 11.1% of the cases with p.Glu487Lys in KRT2.

    DOI: 10.3390/ijms23147791

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  12. 経過観察中に水疱性類天疱瘡を発症した、MV遺伝子変異を有する高齢発症の汗孔角化症の2例

    有沢 友希, 武市 拓也, 伊藤 靖敏, 棚橋 華奈, 室 慶直, 荻 朋男, 秋山 真志

    加齢皮膚医学セミナー   Vol. 17 ( 1 ) page: 74 - 75   2022.6

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    Language:Japanese   Publisher:加齢皮膚医学研究会  

  13. 14例の長島型掌蹠角化症における、SERPINB7創始者変異のアレル頻度の解析

    伊藤 靖敏, 武市 拓也, 棚橋 華奈, 吉川 剛典, 村瀬 友哉, 室 慶直, 秋山 真志, 池田 賢太, 森実 真, 川上 佳夫, 中村 保夫, 武藤 潤, 大磯 直毅, 清島 真理子, 川田 暁, 杉浦 一充, 須賀 康, 荻 朋男

    角化症研究会記録集   Vol. 36   page: 45 - 48   2022.6

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    Language:Japanese   Publisher:角化症研究会事務局  

  14. KRT2のmutation hotspotに変異を有する、表在性表皮融解性魚鱗癬の1家系

    鈴木 由以佳, 武市 拓也, 棚橋 華奈, 室 慶直, 秋山 真志, 須賀 康

    角化症研究会記録集   Vol. 36   page: 83 - 85   2022.6

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    Language:Japanese   Publisher:角化症研究会事務局  

  15. KRT2のmutation hotspotに変異を有する、表在性表皮融解性魚鱗癬の1家系

    鈴木 由以佳, 武市 拓也, 棚橋 華奈, 室 慶直, 秋山 真志, 須賀 康

    角化症研究会記録集   Vol. 36   page: 83 - 85   2022.6

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    Language:Japanese   Publisher:角化症研究会事務局  

  16. 14例の長島型掌蹠角化症における、SERPINB7創始者変異のアレル頻度の解析

    伊藤 靖敏, 武市 拓也, 棚橋 華奈, 吉川 剛典, 村瀬 友哉, 室 慶直, 秋山 真志, 池田 賢太, 森実 真, 川上 佳夫, 中村 保夫, 武藤 潤, 大磯 直毅, 清島 真理子, 川田 暁, 杉浦 一充, 須賀 康, 荻 朋男

    角化症研究会記録集   Vol. 36   page: 45 - 48   2022.6

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  17. びまん性大細胞型B細胞リンパ腫を発症した1型高IgE症候群の孤発例

    鈴木 由以佳, 棚橋 華奈, 伊藤 靖敏, 葉名尻 良, 高間 寛之, 渡辺 大輔, 秋山 真志

    日本皮膚科学会雑誌   Vol. 132 ( 5 ) page: 1370 - 1370   2022.5

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  18. 表皮融解性魚鱗癬の1例

    尾崎 雅史, 葉山 惟大, 藤田 英樹, 長野 伸彦, 土方 みどり, 棚橋 華奈, 武市 拓也, 秋山 真志

    日本皮膚科学会雑誌   Vol. 132 ( 3 ) page: 512 - 512   2022.3

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  19. 二種類の穿孔性皮膚症を発症した高齢者の一例

    岩田 真衣, 村瀬 友哉, 武市 拓也, 棚橋 華奈, 高間 寛之, 山田 元人, 秋山 真志

    加齢皮膚医学セミナー   Vol. 16 ( 2 ) page: 44 - 44   2021.12

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  20. Updated allele frequencies of SERPINB7 founder mutations in Asian patients with Nagashima-type palmoplantar keratosis/keratoderma. International journal

    Yasutoshi Ito, Takuya Takeichi, Kenta Ikeda, Kana Tanahashi, Takenori Yoshikawa, Yuya Murase, Yoshinao Muro, Yoshio Kawakami, Yasuo Nakamura, Kanako Matsuyama, Jun Muto, Naoki Oiso, Shin Morizane, Kazumitsu Sugiura, Yasushi Suga, Mariko Seishima, Akira Kawada, Tomoo Ogi, Masashi Akiyama

    Journal of dermatological science   Vol. 103 ( 2 ) page: 116 - 119   2021.8

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  21. Identification of a novel causative mutation in KRT1 in diffuse palmoplantar keratoderma, facilitated by whole-exome sequencing. International journal

    So Takeuchi, Takuya Takeichi, Yasutoshi Ito, Kana Tanahashi, Yoshinao Muro, Tomoo Ogi, Masashi Akiyama

    European journal of dermatology : EJD   Vol. 31 ( 2 ) page: 264 - 265   2021.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1684/ejd.2021.4017

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  22. Two Cases of Porokeratosis with MVD Mutations, in Association with Bullous Pemphigoid

    Arisawa Y, Ito Y, Tanahashi K, Muro Y, Ogi T, Takeichi T, Akiyama M

    Acta dermato-venereologica     2021.2

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  23. A patient with CARD14-associated papulosquamous eruptions showing atopic dermatitis-like features

    Takeichi T., Terawaki S., Kubota Y., Ito Y., Tanahashi K., Muro Y., Akiyama M.

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   Vol. 35 ( 1 ) page: E58 - E59   2021.1

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    Publisher:Journal of the European Academy of Dermatology and Venereology  

    DOI: 10.1111/jdv.16799

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  24. 水疱性類天疱瘡を合併した汗孔角化症の1例

    有沢 友希, 武市 拓也, 棚橋 華奈, 秋山 真志

    皮膚の科学   Vol. 19 ( 4 ) page: 270 - 270   2020.12

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    Language:Japanese   Publisher:日本皮膚科学会-大阪地方会・京滋地方会  

  25. Cutaneous extramedullary hematopoiesis in a patient with secondary myelofibrosis due to MPL gene mutation

    Murase Y., Takeichi T., Tanahashi K., Marumo Y., Suzuki Y., Nakamura S., Akiyama M.

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY     2020.11

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    Publisher:Journal of the European Academy of Dermatology and Venereology  

    DOI: 10.1111/jdv.16990

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  26. Acquired reactive perforating collagenosis with chondrodermatitis nodularis chronica helicis

    Murase Yuya, Takeichi Takuya, Tanahashi Kana, Takama Hiroyuki, Akiyama Masashi

    JOURNAL OF DERMATOLOGY   Vol. 47 ( 10 ) page: E362 - E364   2020.10

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    Publisher:Journal of Dermatology  

    DOI: 10.1111/1346-8138.15525

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  27. Association of Topical Minoxidil With Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Pathogenic Variants

    Taki Tomoki, Tanahashi Kana, Takeichi Takuya, Yoshikawa Takenori, Murase Yuya, Sugiura Kazumitsu, Akiyama Masashi

    JAMA DERMATOLOGY   Vol. 156 ( 10 ) page: 1030 - 1032   2020.10

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  28. Mild epidermolytic ichthyosis with palmoplantar keratoderma due to the KRT1 mutation p.lle479Thr

    Murase Yuya, Tanahashi Kana, Takeichi Takuya, Sugiura Kazumitsu, Aiyama Akiteru, Nishida Keigo, Mitsuma Teruyuki, Akiyama Masashi

    JOURNAL OF DERMATOLOGY   Vol. 47 ( 9 ) page: E336 - E339   2020.9

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    Publisher:Journal of Dermatology  

    DOI: 10.1111/1346-8138.15476

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  29. Frequent FOXA1-Activating Mutations in Extramammary Paget's Disease

    Takeichi Takuya, Okuno Yusuke, Matsumoto Takaaki, Tsunoda Nobuyuki, Suzuki Kyogo, Tanahashi Kana, Kono Michihiro, Kikumori Toyone, Muro Yoshinao, Akiyama Masashi

    CANCERS   Vol. 12 ( 4 )   2020.4

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  30. SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation

    Takeichi Takuya, Hirabayashi Tetsuya, Miyasaka Yuki, Kawamoto Akane, Okuno Yusuke, Taguchi Shijima, Tanahashi Kana, Murase Chiaki, Takama Hiroyuki, Tanaka Kosei, Boeglin William E., Calcutt M. Wade, Watanabe Daisuke, Kono Michihiro, Muro Yoshinao, Ishikawa Junko, Ohno Tamio, Brash Alan R., Akiyama Masashi

    JOURNAL OF CLINICAL INVESTIGATION   Vol. 130 ( 2 ) page: 890 - 903   2020.2

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    Publisher:Journal of Clinical Investigation  

    DOI: 10.1172/JCI130675

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  31. Homozygous variant p.Ser427Pro in PNPLA1 is a preventive factor from atopic dermatitis

    Watanabe Naoki, Kono Michihiro, Suganuma Mutsumi, Tanahashi Kana, Akiyama Masashi

    JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 97 ( 1 ) page: 86 - 88   2020.1

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    Publisher:Journal of Dermatological Science  

    DOI: 10.1016/j.jdermsci.2019.12.006

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  32. Reduced stratum corneum acylceramides in autosomal recessive congenital ichthyosis with a NIPAL4 mutation

    Murase Yuya, Takeichi Takuya, Kawamoto Akane, Tanahashi Kana, Okuno Yusuke, Takama Hiroyuki, Shimizu Eri, Ishikawa Junko, Ogi Tomoo, Akiyama Masashi

    JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 97 ( 1 ) page: 50 - 56   2020.1

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    Publisher:Journal of Dermatological Science  

    DOI: 10.1016/j.jdermsci.2019.12.001

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  33. Autosomal dominant progressive hyperpigmentation and lentigines in a Japanese pedigree due to a missense mutation near the C-terminus of KIT

    Takeichi T., Sugiura K., Tanahashi K., Noda K., Kono M., Akiyama M.

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 179 ( 5 ) page: 1210 - 1211   2018.11

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    Publisher:British Journal of Dermatology  

    DOI: 10.1111/bjd.16895

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  34. Mutational analysis of 29 patients with autosomal-recessive woolly hair and hypotrichosis: LIPH mutations are extremely predominant in autosomal-recessive woolly hair and hypotrichosis in Japan

    Takeichi T., Tanahashi K., Taki T., Kono M., Sugiura K., Akiyama M.

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 177 ( 1 ) page: 290 - 292   2017.7

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    Publisher:British Journal of Dermatology  

    DOI: 10.1111/bjd.15070

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  35. Noteworthy clinical findings of harlequin ichthyosis: digital autoamputation caused by cutaneous constriction bands in a case with novel ABCA12 mutationse

    Tanahashi K., Sugiura K., Sato T., Akiyama M.

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 174 ( 3 ) page: 689 - 691   2016.3

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    Publisher:British Journal of Dermatology  

    DOI: 10.1111/bjd.14228

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  36. Novel indel mutation of STS underlies a new phenotype of self-healing recessive X-linked ichthyosis

    Takeichi Takuya, Sugiura Kazumitsu, Hsu Chao-Kai, Tanahashi Kana, Takama Hiroyuki, Simpson Michael A., McGrath John A., Akiyama Masashi

    JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 79 ( 3 ) page: 317 - 319   2015.9

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    Publisher:Journal of Dermatological Science  

    DOI: 10.1016/j.jdermsci.2015.07.001

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  37. Topical minoxidil improves congenital hypotrichosis caused by LIPH mutations

    Tanahashi K., Sugiura K., Akiyama M.

    BRITISH JOURNAL OF DERMATOLOGY   Vol. 173 ( 3 ) page: 865 - 866   2015.9

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    Publisher:British Journal of Dermatology  

    DOI: 10.1111/bjd.13790

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  38. Disappearance of circulating autoantibodies to RNA polymerase III in a patient with systemic sclerosis successfully treated with corticosteroid and methotrexate

    Tanahashi K., Sugiura K., Muro Y., Akiyama M.

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   Vol. 29 ( 7 ) page: 1453 - 1454   2015.7

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    Publisher:Journal of the European Academy of Dermatology and Venereology  

    DOI: 10.1111/jdv.12512

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  39. TRPS1 Haploinsufficiency Results in Increased STAT3 and SOX9 mRNA Expression in Hair Follicles in Trichorhinophalangeal Syndrome

    Shibata Akitaka, Tanahashi Kana, Sugiura Kazumitsu, Akiyama Masashi

    ACTA DERMATO-VENEREOLOGICA   Vol. 95 ( 5 ) page: 620 - 621   2015

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    Publisher:Acta Dermato-Venereologica  

    DOI: 10.2340/00015555-1948

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  40. AUTOSOMAL RECESSIVE WOOLLY HAIR/HYPOTRICHOSIS CAUSED BY HIGHLY PREVALENT LIPH FOUNDER MUTATIONS IN JAPAN

    Murase Chiaki, Sugiura Kazumitsu, Tanahashi Kana, Matsumoto Kentarou, Watanabe Daisuke, Akiyama Masashi

    JOURNAL OF DERMATOLOGY   Vol. 41   page: 8 - 8   2014.10

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  41. A new EDA gene mutation in a family of X-linked hypohidrotic ectodermal dysplasia

    Ohashi Masafumi, Moriya Chie, Tanahashi Kana, Nakano Hajime, Sawamura Daisuke, Seishima Mariko

    JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 74 ( 2 ) page: 175 - 177   2014.5

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    Publisher:Journal of Dermatological Science  

    DOI: 10.1016/j.jdermsci.2014.01.003

    Web of Science

    Scopus

    PubMed

  42. Highly Prevalent LIPH Founder Mutations Causing Autosomal Recessive Woolly Hair/Hypotrichosis in Japan and the Genotype/Phenotype Correlations

    Tanahashi Kana, Sugiura Kazumitsu, Kono Michihiro, Takama Hiromichi, Hamajima Nobuyuki, Akiyama Masashi

    PLOS ONE   Vol. 9 ( 2 ) page: e89261   2014.2

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  43. Novel TGM1 Missense Mutation p.Arg727Gln in a Case of Self-healing Collodion Baby

    Tanahashi Kana, Sugiura Kazumitsu, Asagoe Kenji, Aoyama Yumi, Iwatsuki Keiji, Akiyama Masashi

    ACTA DERMATO-VENEREOLOGICA   Vol. 94 ( 5 ) page: 589 - 590   2014

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    Publisher:Acta Dermato-Venereologica  

    DOI: 10.2340/00015555-1765

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    Scopus

    PubMed

  44. P-059 プレドニゾロンとタクロリムス内服にて改善した皮膚結節性ループスムチン症(膠原病・自己炎症疾患1,口演8,第26回日本アレルギー学会春季臨床大会)

    杉浦 一充, 棚橋 華奈, 室 慶直, 秋山 真志

    アレルギー   Vol. 63 ( 3 )   2014

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    Publisher:一般社団法人 日本アレルギー学会  

    DOI: 10.15036/arerugi.63.557_3

  45. Lamellar ichthyosis in a collodion baby caused by CYP4F22 mutations in a non-consanguineous family outside the Mediterranean

    Sugiura Kazumitsu, Takeichi Takuya, Tanahashi Kana, Ito Yasutomo, Kosho Tomoki, Saida Ken, Uhara Hisashi, Okuyama Ryuhei, Akiyama Masashi

    JOURNAL OF DERMATOLOGICAL SCIENCE   Vol. 72 ( 2 ) page: 193 - 195   2013.11

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    Publisher:Journal of Dermatological Science  

    DOI: 10.1016/j.jdermsci.2013.06.008

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    PubMed

  46. Cutaneous lupus mucinosis successfully treated with systemic corticosteroid and systemic tacrolimus combination therapy

    Sugiura Kazumitsu, Tanahashi Kana, Muro Yoshinao, Akiyama Masashi

    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY   Vol. 69 ( 4 ) page: E200 - E202   2013.10

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    Publisher:Journal of the American Academy of Dermatology  

    DOI: 10.1016/j.jaad.2013.04.057

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    Scopus

    PubMed

  47. Prevalent founder mutation c.736T > A of LIPH in autosomal recessive woolly hair of Japanese leads to variable severity of hypotrichosis in adulthood

    Tanahashi K., Sugiura K., Takeichi T., Takama H., Shinkuma S., Shimizu H., Akiyama M.

    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY   Vol. 27 ( 9 ) page: 1182 - 1184   2013.9

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    Publisher:Journal of the European Academy of Dermatology and Venereology  

    DOI: 10.1111/j.1468-3083.2012.04526.x

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    Scopus

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MISC 26

  1. 二種類の穿孔性皮膚症を発症した高齢者の一例

    岩田 真衣, 村瀬 友哉, 武市 拓也, 棚橋 華奈, 高間 寛之, 山田 元人, 秋山 真志

    加齢皮膚医学セミナー   Vol. 16 ( 1 ) page: 54 - 54   2021.6

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    Language:Japanese   Publisher:加齢皮膚医学研究会  

  2. 遺伝性対側性色素異常症の孤発例

    鈴木 由以佳, 棚橋 華奈, 武市 拓也, 河野 通浩, 秋山 真志, 小粥 雅明

    日本皮膚科学会雑誌   Vol. 131 ( 5 ) page: 1362 - 1362   2021.5

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  3. 表皮脂質関連遺伝子の異常による先天性魚鱗癬の病態解明と新規治療法の開発

    棚橋 華奈, 武市 拓也, 秋山 真志

    日本皮膚科学会雑誌   Vol. 131 ( 5 ) page: 1429 - 1429   2021.5

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  4. 急激に増大し腫瘤を形成した右頬部結節性筋膜炎の1例

    茜部 穂波, 村上 佳恵, 横田 憲二, 浦田 透, 森 章一郎, 棚橋 華奈, 秋山 真志, 河野 通浩, 井上 優貴

    日本皮膚科学会雑誌   Vol. 131 ( 2 ) page: 357 - 357   2021.2

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  5. 水疱性類天疱瘡を合併した汗孔角化症の1例

    有沢 友希, 武市 拓也, 棚橋 華奈, 秋山 真志

    皮膚の科学   Vol. 19 ( 4 ) page: 270 - 270   2020.12

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    Language:Japanese   Publisher:日本皮膚科学会-大阪地方会・京滋地方会  

  6. LIPH創始者変異により偽性優性遺伝形式を示した先天性乏毛症の1家系

    滝 奉樹, 棚橋 華奈, 武市 拓也, 秋山 真志

    日本皮膚科学会雑誌   Vol. 130 ( 12 ) page: 2585 - 2585   2020.11

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  7. 左眼瞼外側に生じたMucinous carcinoma of the skinの1例

    玉腰 和, 横田 憲二, 棚橋 華奈, 森 章一郎, 浦田 透, 村上 佳恵, 秋山 真志

    日本皮膚科学会雑誌   Vol. 130 ( 12 ) page: 2591 - 2591   2020.11

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  8. ボリコナゾール長期内服患者に認められた多発性日光角化症

    中根 啓允, 棚橋 華奈, 秋山 真志, 河野 通浩, 加藤 愛

    日本皮膚科学会雑誌   Vol. 130 ( 12 ) page: 2588 - 2588   2020.11

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  9. 耳輪慢性結節性軟骨皮膚炎を合併した反応性穿孔性膠原線維症の1例

    岩田 真衣, 村瀬 友哉, 武市 拓也, 棚橋 華奈, 秋山 真志, 高間 寛之

    日本皮膚科学会雑誌   Vol. 130 ( 9 ) page: 2091 - 2091   2020.8

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  10. 頭蓋内浸潤を来し、再発を繰り返した悪性エクリンらせん腺腫の1例

    帆苅 直弘, 横田 憲二, 棚橋 華奈, 鈴木 優香, 棚橋 邦明, 木部 祐士, 澤田 昌樹, 秋山 真志

    日本皮膚科学会雑誌   Vol. 130 ( 5 ) page: 1240 - 1240   2020.5

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  11. 表在性粘液嚢胞の1例

    黒田 ケイ, 棚橋 華奈, 秋山 真志, 吉川 真人

    日本皮膚科学会雑誌   Vol. 130 ( 1 ) page: 108 - 108   2020.1

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  12. 全エクソームシークエンス法で診断に至った、self-healing recessive X-linked ichthyosisの1例

    武市 拓也, 棚橋 華奈, 秋山 真志, 高間 寛之, 杉浦 一充

    角化症研究会記録集   Vol. 31   page: 39 - 41   2017.3

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    Language:Japanese   Publisher:角化症研究会事務局  

  13. FISH法によるSTS欠失検索が診断に無効であったX連鎖性劣性魚鱗癬(RXLI)

    秋山 真志, 武市 拓也, 杉浦 一充, 棚橋 華奈, 高間 寛之

    日本皮膚科学会雑誌   Vol. 126 ( 6 ) page: 1149 - 1149   2016.5

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  14. 肺小細胞癌の皮膚転移との鑑別を要したメルケル細胞癌の1例

    岡島 梓, 横田 憲二, 松本 高明, 長谷川 佳恵, 秋山 真志, 棚橋 華奈, 森 誉子, 福本 瞳, 片野 晴隆

    日本皮膚科学会雑誌   Vol. 125 ( 5 ) page: 1076 - 1076   2015.4

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  15. 地中海沿岸地域以外で認められた、CYP4F22遺伝子変異による葉状魚鱗癬症例

    杉浦 一充, 武市 拓也, 棚橋 華奈, 秋山 真志, 古庄 知己, 宇原 久, 奥山 隆平, 才田 謙

    角化症研究会記録集   Vol. 29   page: 24 - 27   2015.3

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  16. Cellular Benign Fibrous Histiocytomaの1例

    磯野 公美, 浅見 友梨, 棚橋 華奈, 嘉陽 織江, 大野 稔之, 清水 真

    皮膚科の臨床   Vol. 57 ( 1 ) page: 128 - 129   2015.1

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    Language:Japanese   Publisher:金原出版(株)  

    34歳男。約1年前より右肩に暗紫色の隆起性結節が出現した。初診時、右肩に弾性硬で下床との可動性がない径2cm大の暗紫色の結節を認め、エコー検査では低エコー腫瘤で、内部不均一で周囲から流入するように血管が豊富に存在したため、全摘生検を施行した。病理組織学的に腫瘍は比較的境界明瞭で真皮内に存在し、脂肪組織へ圧排性に増殖していた。比較的均一な紡錘形細胞を主体とし、花むしろ状の配列を成して密に増殖していた。腫瘍内は血管が豊富で、泡沫細胞の集簇やヘモジデリンの沈着が散見され、核分裂像も認めたが異型性に乏しかった。腫瘍細胞は免疫染色でデスミン、S-100、bcl-2、CD34のいずれも陰性、第XIIIa因子は組織球様細胞と少数の紡錘形細胞に陽性であった。CD31は組織球成分に陽性であったが、紡錘細胞では陰性を示した。MIB-1は5〜10%陽性であった。腫瘍全摘術を施行し、cellular benign fibrous histiocytomaと診断した。術後1年4ヵ月の現在、再発は認めていない。

  17. 巨大腫瘤を生じた頭部乳頭状皮膚炎の1例

    山本 真由美, 渡邊 華奈, 渋谷 佳直, 加納 宏行, 清島 真理子, 永井 美貴

    日本皮膚科学会雑誌   Vol. 124 ( 12 ) page: 2316 - 2316   2014.11

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  18. AUTOSOMAL RECESSIVE WOOLLY HAIR/HYPOTRICHOSIS CAUSED BY HIGHLY PREVALENT LIPH FOUNDER MUTATIONS IN JAPAN

    Chiaki Murase, Kazumitsu Sugiura, Kana Tanahashi, Kentarou Matsumoto, Daisuke Watanabe, Masashi Akiyama

    JOURNAL OF DERMATOLOGY   Vol. 41   page: 8 - 8   2014.10

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:WILEY-BLACKWELL  

    Web of Science

  19. シェーグレン症候群合併の全身性エリテマトーデスを生じたヒトアジュバント病の1例

    高橋 智子, 棚橋 華奈, 加納 宏行, 清島 真理子

    中部リウマチ   Vol. 44 ( 1 ) page: 53 - 53   2014.7

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  20. 抗RNAポリメラーゼ(RNAP)III抗体が診断に有用であった強皮症の1例

    棚橋 華奈, 杉浦 一充, 室 慶直, 秋山 真志

    中部リウマチ   Vol. 44 ( 1 ) page: 54 - 54   2014.7

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  21. プレドニゾロンとタクロリムス内服にて改善した皮膚結節性ループスムチン症

    杉浦 一充, 棚橋 華奈, 室 慶直, 秋山 真志

    アレルギー   Vol. 63 ( 3-4 ) page: 557 - 557   2014.4

  22. cellular benign fibrous histiocytomaの1例

    磯野 公美, 浅見 友梨, 棚橋 華奈, 大野 稔之, 嘉陽 織江, 清水 真

    日本皮膚科学会雑誌   Vol. 123 ( 7 ) page: 1256 - 1256   2013.6

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  23. アートメイク後にみられたサルコイド反応の1例

    磯野 公美, 浅見 友梨, 棚橋 華奈, 嘉陽 織江, 大野 稔之, 清水 真

    日本臨床皮膚科医会雑誌   Vol. 30 ( 2 ) page: 239 - 239   2013.4

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  24. 血液培養よりStreptobacillus moniliformisを検出した鼠咬症の1例

    浅見 友梨, 磯野 公美, 棚橋 華奈, 嘉陽 織江, 大野 稔之, 清水 真

    日本臨床皮膚科医会雑誌   Vol. 30 ( 2 ) page: 249 - 249   2013.4

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  25. 歯牙の異常をともなったLIPH変異による先天性乏毛症の一例

    棚橋 華奈, 杉浦 一充, 秋山 真志

    日本皮膚科学会雑誌   Vol. 123 ( 5 ) page: 992 - 992   2013.4

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  26. 名古屋大学皮膚科における先天性乏毛症の遺伝子解析結果

    棚橋 華奈, 杉浦 一充, 秋山 真志

    日本皮膚科学会雑誌   Vol. 123 ( 4 ) page: 498 - 498   2013.4

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Research Project for Joint Research, Competitive Funding, etc. 6

  1. 常染色体劣性先天性魚鱗癬における表皮脂質異常と分化異常のメカニズムの解明

    Grant number:2 0 K 1 7 3 4 8  2020.4

    日本学術振興会  科学研究費助成事業 若手研究 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

  2. 先天性魚鱗癬における表皮脂質異常と表皮細胞分化障害のクロストークの解明

    2020.4 - 2021.3

    2020年度日比野基金医学研究助成 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\500000

  3. 表皮脂質関連遺伝子の異常による先天性魚鱗癬の病態解明と新規治療法の開発

    2019.4 - 2020.3

    2019年度基礎医学研究費(資生堂寄付) 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000

  4. 次世代シークエンサーを用いた常染色体劣性先天性魚鱗癬の新規病因遺伝子の検索と包括的病態解明および新規治療法の研究

    2018 - 2019

    平成30年度医学研究奨励助成事業(臨床枠) 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000

  5. アトピー性皮膚炎患者の皮膚バリア機能に関与する新規病因遺伝子の検索

    2017.11 - 2019.3

    GlaxoSmithKline Research Grant 2017 

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    Grant type:Competitive

    Grant amount:\2000000

  6. 先天性魚鱗癬様紅皮症におけるABCA12のエクソン欠損と発現量低下の解明

    2014 - 2015

    平成26年度一般財団法人共済団医学研究奨励助成金 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\500000

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. 先天性魚鱗癬の病態におけるリゾリン脂質の役割解明と新規治療標的への展開

    Grant number:22K16260  2022.4 - 2024.3

    科学研究費助成事業  若手研究

    棚橋 華奈

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    本研究は、常染色体劣性先天性魚鱗癬(autosomal recessive congenital ichthyosis: ARCI)の包括的病態解明と新規治療法開発に直結する基礎的データを得ることを目的とする。具体的には、ARCI表皮モデル及びモデルマウスについて、表皮分化、リゾリン脂質などの脂質メディエーター、サイトカインに関連する遺伝子発現の変化を分析することで、表皮脂質異常が表皮の分化・増殖に影響をもたらすメカニズムを解明する。

  2. Elucidation of crosstalk between epidermal lipid abnormality/barrier defects and inflammation in ichthyosis for innovation of novel treatments

    Grant number:21H02941  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  3. 常染色体劣性先天性魚鱗癬における表皮脂質異常と分化異常のメカニズムの解明

    Grant number:20K17348  2020.4 - 2022.3

    若手研究

    棚橋 華奈

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    Authorship:Principal investigator 

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    本研究は、最重症の魚鱗癬である道化師様魚鱗癬を含む常染色体劣性先天性魚鱗癬(autosomal recessive congenital ichthyosis: ARCI)の包括的病態解明と新規治療法開発に直結する基礎的データを得ることを目的とする。具体的には、胎生期から成体まで観察が可能なARCIモデルマウスを樹立し、表皮分化、脂質代謝、サイトカインなどの変化を分析することで、表皮脂質異常が表皮の分化・増殖に影響をもたらすメカニズムを解明し、魚鱗癬治療候補薬を見つけ出す。本研究の成果は皮膚バリア障害を発症因子とするアレルギー性疾患の予防、治療へと波及することが期待される。