Updated on 2024/04/02

写真a

 
ARIMA Akihide
 
Organization
Institutes of Innovation for Future Society Designated lecturer
Title
Designated lecturer

Degree 1

  1. 博士(理学) ( 2016.3   大阪大学 ) 

Research Interests 3

  1. ナノバイオデバイス

  2. ナノポア

  3. マイクロ・ナノデバイス

Research Areas 2

  1. Nanotechnology/Materials / Nanobioscience

  2. Nanotechnology/Materials / Nano/micro-systems

Current Research Project and SDGs 1

  1. ナノバイオデバイスを用いた単一生体粒子分析

Research History 4

  1. 名古屋大学 未来社会創造機構 ナノライフシステム研究所   量子科学技術・量子生命科学研究部門   特任講師

    2021.4

  2. Nagoya University   Graduate School of Engineering, Biomolecular Engineering   Designated assistant professor

    2019.4 - 2021.3

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    Country:Japan

  3. Osaka University   The Institute of Scientific and Industrial Research   Designated assistant professor

    2016.4 - 2019.3

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    Country:Japan

  4. 日本学術振興会特別研究員(DC2)

    2015.4 - 2016.3

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    Country:Japan

Education 3

  1. Osaka University   Graduate School, Division of Natural Science

    2013.4 - 2016.3

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    Country: Japan

  2. Osaka University   Graduate School, Division of Natural Science

    2011.4 - 2013.3

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    Country: Japan

  3. Osaka University   Faculty of Science

    2007.4 - 2011.3

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    Country: Japan

Professional Memberships 4

  1. THE JAPAN SOCIETY OF APPLIED PHYSICS

  2. THE CHEMICAL SOCIETY OF JAPAN

  3. THE SOCIETY FOR CHEMISTRY AND MICRO-NANO SYSTEMS

  4. 日本分析化学会

Awards 6

  1. 令和元年度 若手優秀賞

    2020.3   一般社団法人 化学とマイクロ・ナノシステム学会   ナノポアデバイスによる単一生体粒子分析

    有馬 彰秀

  2. 令和元年度愛知県若手研究者イノベーション創出奨励事業 第14回わかしゃち奨励賞 優秀賞

    2019.1   愛知県・(公財)科学技術交流財団・(公財)日比科学技術振興財団   ナノバイオデバイスを用いた革新的1細胞診断法の創成

    有馬 彰秀

  3. ImPACT宮田プログラム公開成果報告会 優秀賞

    2018.12   国立研究開発法人 科学技術振興機構 革新的研究開発推進プログラム(ImPACT)   ナノポアセンサの社会実装に向けた取り組み

    有馬彰秀

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  4. 化学とマイクロ・ナノシステム学会 第36回研究会 優秀研究賞

    2017.10   一般社団法人 化学とマイクロ・ナノシステム学会   糖鎖修飾ナノポアによるウイルス検出と感染能評価

    有馬彰秀, 堀口諭吉, 筒井真楠, 殿村渉, 横田一道, 谷口正輝, 宮原裕二, 川合知二

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  5. 第5回ナノスケール分子デバイス若手セミナー 奨励賞

    2016.3   日本化学会 新研究領域グループ ナノスケール分子デバイス   ナノポアトラップ法を用いた単一微粒子分析

    有馬 彰秀

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  6. 第五回夏期セミナー 若手優秀賞

    2011.8   日本分析化学会近畿支部  

    有馬 彰秀

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Papers 26

  1. デジタル・トランスフォーメーションで変わる医療: ナノバイオデバイス、量子科学技術とAIが拓く未来医療

    有馬 彰秀, 馬場 嘉信

    Pharm Tech. Japan   Vol. 37   2021.4

  2. Oxide Nanowire Microfluidic Devices for Capturing Single-stranded DNAs Reviewed

    Marina Musa, Takao Yasui, Zetao Zhu, Kazuki Nagashima, Miki Ono, Quanli Liu, Hiromi Takahashi, Taisuke Shimada, Akihide Arima, Takeshi Yanagida, Yoshinobu Baba

    Analytical Sciences     2021.1

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    Publishing type:Research paper (scientific journal)   Publisher:Japan Society for Analytical Chemistry  

    DOI: 10.2116/analsci.20P421

    PubMed

  3. ZnO/SiO2 core/shell nanowires for capturing CpG rich single-stranded DNAs Reviewed

    Marina Musa, Takao Yasui, Kazuki Nagashima, Masafumi Horiuchi, Zetao Zhu, Quanli Liu, Taisuke Shimada, Akihide Arima, Takeshi Yanagida, Yoshinobu Baba

    Analytical Methods   Vol. 13 ( 3 ) page: 337 - 344   2021.1

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    Publishing type:Research paper (scientific journal)   Publisher:Royal Society of Chemistry (RSC)  

    <p>Modification of the surface of ZnO nanowires through atomic layer deposition (ALD) for the fabrication of a ZnO/SiO<sub>2</sub> (core/shell) nanowire microfluidic device for capturing CpG-rich single-stranded DNAs (ssDNAs).</p>

    DOI: 10.1039/d0ay02138e

    Web of Science

    Scopus

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  4. Solid-State Nanopore Platform Integrated with Machine Learning for Digital Diagnosis of Virus Infection

    Akihide Arima, Makusu Tsutsui, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

    Analytical Chemistry   Vol. 93 ( 1 ) page: 215 - 227   2021.1

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acs.analchem.0c04353

    Web of Science

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  5. Digital Pathology Platform for Respiratory Tract Infection Diagnosis via Multiplex Single-Particle Detections Reviewed

    Akihide Arima, Makusu Tsutsui, Takeshi Yoshida, Kenji Tatematsu, Tomoko Yamazaki, Kazumichi Yokota, Shun’ichi Kuroda, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

    ACS Sensors   Vol. 5 ( 11 ) page: 3398 - 3403   2020.11

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acssensors.0c01564

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  6. Machine learning-driven electronic identifications of single pathogenic bacteria Reviewed

    Shota Hattori, Rintaro Sekido, Iat Wai Leong, Makusu Tsutsui, Akihide Arima, Masayoshi Tanaka, Kazumichi Yokota, Takashi Washio, Tomoji Kawai, Mina Okochi

    Scientific Reports   Vol. 10 ( 1 ) page: 15525   2020.9

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    <title>Abstract</title>
    A rapid method for screening pathogens can revolutionize health care by enabling infection control through medication before symptom. Here we report on label-free single-cell identifications of clinically-important pathogenic bacteria by using a polymer-integrated low thickness-to-diameter aspect ratio pore and machine learning-driven resistive pulse analyses. A high-spatiotemporal resolution of this electrical sensor enabled to observe galvanotactic response intrinsic to the microbes during their translocation. We demonstrated discrimination of the cellular motility via signal pattern classifications in a high-dimensional feature space. As the detection-to-decision can be completed within milliseconds, the present technique may be used for real-time screening of pathogenic bacteria for environmental and medical applications.

    DOI: 10.1038/s41598-020-72508-3

    Web of Science

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    Other Link: http://www.nature.com/articles/s41598-020-72508-3

  7. Ammonia-Induced Seed Layer Transformations in a Hydrothermal Growth Process of Zinc Oxide Nanowires Reviewed

    Quanli Liu, Takao Yasui, Kazuki Nagashima, Takeshi Yanagida, Mitsuo Hara, Masafumi Horiuchi, Zetao Zhu, Hiromi Takahashi, Taisuke Shimada, Akihide Arima, Yoshinobu Baba

    The Journal of Physical Chemistry C   Vol. 124 ( 37 ) page: 20563 - 20568   2020.9

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    Publishing type:Research paper (scientific journal)   Publisher:American Chemical Society (ACS)  

    DOI: 10.1021/acs.jpcc.0c05490

    Web of Science

    Scopus

  8. Photolithographically Constructed Single ZnO Nanowire Device and Its Ultraviolet Photoresponse. Reviewed

    Quanli Liu, Takao Yasui, Kazuki Nagashima, Takeshi Yanagida, Masafumi Horiuchi, Zetao Zhu, Hiromi Takahashi, Taisuke Shimada, Akihide Arima, Yoshinobu Baba

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry   Vol. 36 ( 9 ) page: 1125 - 1129   2020.9

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.2116/analsci.20N002

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  9. Photolithographically Constructed Single ZnO Nanowire Device and Its Ultraviolet Photoresponse

    Liu Quanli, Yasui Takao, Nagashima Kazuki, Yanagida Takeshi, Horiuchi Masafumi, Zhu Zetao, Takahashi Hiromi, Shimada Taisuke, Arima Akihide, Baba Yoshinobu

    ANALYTICAL SCIENCES   Vol. 36 ( 9 ) page: 1125 - 1129   2020.9

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  10. Tailoring Dielectric Surface Charge via Atomic Layer Thickness Reviewed

    ACS Applied Materials & Interfaces   Vol. 12 ( 4 ) page: 5025 - 5030   2020.1

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  11. Metal oxide nanowires microfluidic devices as potential tool for DNA methylation mapping

    Musa M.

    MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences     page: 1093 - 1094   2020

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    Publisher:MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences  

    Scopus

  12. Solid-State Nanopore Time-of-Flight Mass Spectrometer Reviewed

    ACS Sensors   Vol. 4 ( 11 ) page: 2974 - 2979   2019.11

  13. High-throughput single nanoparticle detection using a feed-through channel-integrated nanopore. Reviewed

    Tsutsui M, Yamazaki T, Tatematsu K, Yokota K, Esaki Y, Kubo Y, Deguchi H, Arima A, Kuroda S, Kawai T

    Nanoscale   Vol. 11 ( 43 ) page: 20475 - 20484   2019.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9nr07039g

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  14. Electric field interference and bimodal particle translocation in nano-integrated multipores Reviewed

    Makusu Tsutsui, Kazumichi Yokota, Tomoko Nakada, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, Tomoji Kawai

    Nanoscale   Vol. 11 ( 16 ) page: 7547 - 7553   2019.4

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  15. High-throughput single-particle detections using a dual-height-channel-integrated pore Reviewed

    Wataru Tonomura, Makusu Tsutsui, Akihide Arima, Kazumichi Yokota, Masater Taniguchi, Takashi Washio, Tomoji Kawai

    Lab on a Chip   Vol. 19 ( 8 ) page: 1352 - 1358   2019.4

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  16. Volume discrimination of nanoparticles via electrical trapping using nanopores Reviewed

    Akihide Arima, Makusu Tsutsui, Masateru Taniguchi

    Journal of Nanobiotechnology   Vol. 17 ( 1 ) page: 40   2019.3

  17. Silicon substrate effects on ionic current blockade in solid-state nanopores Reviewed

    Makusu Tsutsui, Kazumichi Yokota, Tomoko Nakada, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, Tomoji Kawai

    Nanoscale   Vol. 11 ( 10 ) page: 4190 - 4197   2019.3

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  18. Identifying multiple viral species at a single particle level using a combination of nanopores and machine leaning approach

    Arima A.

    23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019     page: 1238 - 1239   2019

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    Publisher:23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019  

    Scopus

  19. Particle Capture in Solid-State Multipores Reviewed

    Makusu Tsutsui, Kazumichi Yokota, Tomoko Nakada, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, Tomoji Kawai

    ACS Sensors   Vol. 3 ( 12 ) page: 2693 - 2701   2018.12

  20. Identifying Single Viruses Using Biorecognition Solid-State Nanopores Reviewed

    Arima, A., Harlisa, I.H., Yoshida, T., Tsutsui, M., Tanaka, M., Yokota, K., Tonomura, W., Yasuda, J., Taniguchi, M., Washio, T., Okochi, M., Kawai, T.

    Journal of the American Chemical Society   Vol. 140 ( 48 ) page: 16834 - 16841   2018.12

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.8b10854

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  21. Selective detections of single-viruses using solid-state nanopores Reviewed

    Arima, A., Tsutsui, M., Harlisa, I.H., Yoshida, T., Tanaka, M., Yokota, K., Tonomura, W., Taniguchi, M., Okochi, M., Washio, T., Kawai, T.

    Scientific Reports   Vol. 8 ( 1 ) page: 16305   2018.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-34665-4

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  22. Temporal Response of Ionic Current Blockade in Solid-State Nanopores. Reviewed

    Tsutsui M, Yokota K, Arima A, Tonomura W, Taniguchi M, Washio T, Kawai T

    ACS applied materials & interfaces   Vol. 10 ( 40 ) page: 34751 - 34757   2018.10

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsami.8b11819

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  23. 糖鎖修飾ナノポアによるウイルス検出と感染能評価 Invited

    有馬彰秀, 堀口諭吉, 筒井真楠, 殿村渉, 横田一道, 谷口正輝, 宮原裕二, 川合知二

    化学とマイクロ・ナノシステム   Vol. 17 ( 1 ) page: 27 - 30   2018.3

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    Language:Japanese  

  24. Identification of Individual Bacterial Cells through the Intermolecular Interactions with Peptide-Functionalized Solid-State Pores. Reviewed International journal

    Makusu Tsutsui, Masayoshi Tanaka, Takahiro Marui, Kazumichi Yokota, Takeshi Yoshida, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, Mina Okochi, Tomoji Kawai

    Analytical chemistry   Vol. 90 ( 3 ) page: 1511 - 1515   2018.2

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    Publishing type:Research paper (scientific journal)  

    Bioinspired pore sensing for selective detection of flagellated bacteria was investigated. The Au micropore wall surface was modified with a synthetic peptide designed from toll-like receptor 5 (TLR5) to mimic the pathogen-recognition capability. We found that intermolecular interactions between the TLR5-derived recognition peptides and flagella induce ligand-specific perturbations in the translocation dynamics of Escherichia coli, which facilitated the discrimination between the wild-type and flagellin-deletion mutant (ΔfliC) by the resistive pulse patterns thereby demonstrating the sensing of bacteria at a single-cell level. These results provide a novel concept of utilizing weak intermolecular interactions as a recognition probes for single-cell microbial identification.

    DOI: 10.1021/acs.analchem.7b04950

    PubMed

  25. Discriminating single-bacterial shape using low-aspect-ratio pores Reviewed

    Makusu Tsutsui, Takeshi Yoshida, Kazumichi Yokota, Hirotoshi Yasaki, Takao Yasui, Akihide Arima, Wataru Tonomura, Kazuki Nagashima, Takeshi Yanagida, Noritada Kaji, Masateru Taniguchi, Takashi Washio, Yoshinobu Baba, Tomoji Kawai

    SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page: 17371   2017.12

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    Publishing type:Research paper (scientific journal)   Publisher:NATURE PUBLISHING GROUP  

    Conventional concepts of resistive pulse analysis is to discriminate particles in liquid by the difference in their size through comparing the amount of ionic current blockage. In sharp contrast, we herein report a proof-of-concept demonstration of the shape sensing capability of solid-state pore sensors by leveraging the synergy between nanopore technology and machine learning. We found ionic current spikes of similar patterns for two bacteria reflecting the closely resembled morphology and size in an ultra-low thickness-to-diameter aspect-ratio pore. We examined the feasibility of a machine learning strategy to pattern-analyse the sub-nanoampere corrugations in each ionic current waveform and identify characteristic electrical signatures signifying nanoscopic differences in the microbial shape, thereby demonstrating discrimination of single-bacterial cells with accuracy up to 90%. This data-analytics-driven microporescopy capability opens new applications of resistive pulse analyses for screening viruses and bacteria by their unique morphologies at a single-particle level.

    DOI: 10.1038/s41598-017-17443-6

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  26. Rapid structural analysis of nanomaterials in aqueous solutions Reviewed

    Sou Ryuzaki, Makusu Tsutsui, Yuhui He, Kazumichi Yokota, Akihide Arima, Takanori Morikawa, Masateru Taniguchi, Tomoji Kawai

    NANOTECHNOLOGY   Vol. 28 ( 15 ) page: 155501 - 155501-8   2017.4

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    Publishing type:Research paper (scientific journal)   Publisher:IOP PUBLISHING LTD  

    Rapid structural analysis of nanoscale matter in a liquid environment represents innovative technologies that reveal the identities and functions of biologically important molecules. However, there is currently no method with high spatio-temporal resolution that can scan individual particles in solutions to gain structural information. Here we report the development of a nanopore platform realizing quantitative structural analysis for suspended nanomaterials in solutions with a high z-axis and xy-plane spatial resolution of 35.8 +/- 1.1 and 12 nm, respectively. We used a low thickness-to-diameter aspect ratio pore architecture for achieving cross sectional areas of analyte (i.e. tomograms). Combining this with multiphysics simulation methods to translate ionic current data into tomograms, we demonstrated rapid structural analysis of single polystyrene (Pst) beads and single dumbbell-like Pst beads in aqueous solutions.

    DOI: 10.1088/1361-6528/aa5e66

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KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. 機能性ナノチャネル構造を用いた網羅的1細胞解析法の創成

    2019.4 - 2022.3

    日本学術振興会  基盤研究(B)  基盤研究(B)

    有馬 彰秀, 筒井真楠

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    Authorship:Principal investigator  Grant type:Competitive

  2. ナノポアトラップ法を利用した包括的1細胞解析法の創成

    2017.4 - 2019.3

    日本学術振興会  若手研究(B)  若手研究(B)

    有馬 彰秀

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    Authorship:Principal investigator  Grant type:Competitive

  3. ナノポアトラップ法を利用したナノキャリアの電気的捕捉と融合による微小反応場の創出

    2016.4 - 2017.3

    日本学術振興会  研究活動スタート支援  研究活動スタート支援

    有馬 彰秀

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    Authorship:Principal investigator  Grant type:Competitive

  4. 多重ナノ電極組込ウェルデバイスによる単一生体分子形態識別法の創成

    2015.4 - 2016.3

    科学研究費補助金 

Industrial property rights 2

  1. 流路

    筒井真楠, 横田一道, 有馬彰秀, 殿村渉, 谷口正輝, 鷲尾隆, 川合知二

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    Application no:特願2018-131885  Date applied:2018.7

  2. 流路デバイスおよび微粒子濃縮方法

    殿村渉, 筒井真楠, 横田一道, 有馬彰秀, 谷口正輝, 川合知二

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    Application no:特願2017-100218  Date applied:2017.5

 

Teaching Experience (Off-campus) 1

  1. 化学生命工学実験1

    Nagoya University)