Updated on 2022/08/30

写真a

 
TOKUTAKE Katsuhiro
 
Organization
Graduate School of Medicine Department of Upper and Lower Limb Traumatology Endowed Chair Designated assistant professor
Title
Designated assistant professor

Degree 1

  1. 博士(医学) ( 2019.3   名古屋大学 ) 

Research Areas 1

  1. Life Science / Orthopedics

Research History 2

  1. Nagoya University   Designated assistant professor

    2020.11

  2. Nagoya University   Assistant professor of hospital

    2019.4 - 2020.10

Education 2

  1. Nagoya University

    2015.4 - 2019.3

  2. Mie University

    2002.4 - 2008.3

 

Papers 20

  1. A Therapeutic Strategy for Lower Motor Neuron Disease and Injury Integrating Neural Stem Cell Transplantation and Functional Electrical Stimulation in a Rat Model Reviewed International journal

    Tokutake Katsuhiro, Takeuchi Masaru, Kurimoto Shigeru, Saeki Sota, Asami Yuta, Onaka Keiko, Saeki Masaomi, Aoyama Tadayoshi, Hasegawa Yasuhisa, Hirata Hitoshi

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 23 ( 15 )   2022.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms23158760

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  2. Functional Reconstruction of Denervated Muscle by Xenotransplantation of Neural Cells from Porcine to Rat Reviewed International journal

    Saeki Sota, Tokutake Katsuhiro, Takasu Masaki, Kurimoto Shigeru, Asami Yuta, Onaka Keiko, Saeki Masaomi, Hirata Hitoshi

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 23 ( 15 )   2022.8

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  3. Predictive factors for mortality after distal femoral fractures in the elderly: A retrospective multicenter (TRON group) study. Reviewed International journal

    Yamada Y, Takegami Y, Tokutake K, Taguchi K, Kuwahara Y, Komaki K, Imagama S

    Injury   Vol. 53 ( 3 ) page: 1225 - 1230   2022.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Injury  

    Purpose: This retrospective multicenter study aimed to assess the 1-year mortality rate in elderly patients with distal femoral fractures (DFFs) and identify potential risk factors for mortality. Methods: We analyzed 321 patients aged 65 years and older with DFFs treated surgically between 2012 and 2019 in 13 hospitals. Patient demographics and surgical characteristics were extracted from medical records and radiographs. We used univariable and multivariable Cox regression analyses to identify the factors affecting mortality. Results: The mortality rate for DFFs in elderly patients at 1 year was 9.0%. Multivariable Cox regression analysis revealed older age, male sex, underweight (body mass index [BMI] <18.5 kg/m2), bedridden status, and nursing home residency to be independent predictors for mortality (older age: hazard ratio [HR] 1.07, 95% confidence interval [CI] 1.03–1.11, P<0.001; male sex: HR 3.08, 95% CI 1.23–7.71, P=0.015; underweight: HR 1.93, 95% CI 1.01–3.68, P=0.045; bedridden status: HR 4.59, 95% CI 1.61–13.07, P=0.0042; and nursing home residency: HR 2.63, 95% CI 1.18–5.83, P=0.017). None of the factors associated with surgery including types of fixation, time from initial visit to surgery, blood loss during operation, and operation time was an independent predictor for mortality. Conclusion: The 1-year mortality rate in elderly patients with DFFs was relatively low at 9.0%. Older age, lower BMI, and nursing home residency were associated with mortality after surgery for DFFs. Factors associated with the surgical procedure were not significant predictors.

    DOI: 10.1016/j.injury.2022.01.002

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  4. Low body mass index is a risk factor for increased post-operative mortality and poor functional improvement in distal femur fractures among patients aged over 65: A multicentre (TRON) study. Reviewed International journal

    Kuwahara Y, Takegami Y, Tokutake K, Yamada Y, Komaki K, Imagama S

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association     2022.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Orthopaedic Science  

    Background: Distal femur fractures have been reported to have a mortality rate comparable to hip fractures, but the risk is still unknown. Recent studies have reported that low body mass index (BMI) is a risk factor for mortality in the elderly. We investigated the efficacy of low BMI for predicting the risk of mortality in distal femur fractures in patients aged over 65 within 18 months after injury and its impact on postoperative clinical outcomes and mortality. Methods: Data from patients followed for more than six months were obtained from our trauma research group's database. We investigated risk factors for increased mortality using Cox proportional hazards models. We divided the analysed cases into low (<18.5 kg/m2) and high (>18.5 kg/m2) BMI groups. We adjusted the background characteristics of the groups by patient matching, and evaluated the postoperative mortality, complication rate, and knee society score (KSS). Results: We identified 216 patients, including 58 (26.9%) with low BMI values. Low BMI was an independent risk factor for mortality in all models (Hazard Ratio: 2.9, p = 0.011). The overall survival rate of the low BMI group at 18 months was significantly lower than that of the high BMI group (70.7% vs. 89.1%; p = 0.003). The complication rates of the low BMI and high BMI groups were not significantly different (33.3% vs. 22.2%; p = 0.283). The mean KSS values at 3, 6, and 12 months in the low BMI group was significantly worse than that in the high BMI group (78.7 ± 16.2 vs. 84.8 ± 13.1; p = 0.035, 82.2 ± 16.9 vs. 89.7 ± 8.9; p = 0.005, 86.4 ± 13.0 vs. 91.4 ± 8.4; p = 0.020, respectively). Conclusions: Our study indicated that low BMI was independent associated with increased mortality and impaired postoperative functional recovery in distal femur fractures of the elderly patients.

    DOI: 10.1016/j.jos.2022.01.014

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  5. How does intraoperative fracture malalignment affect postoperative function and bone healing following distal femoral fracture? : a retrospective multicentre study. Reviewed International journal

    Kuwahara Y, Takegami Y, Tokutake K, Yamada Y, Komaki K, Ichikawa T, Imagama S

    Bone & joint open   Vol. 3 ( 2 ) page: 165 - 172   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1302/2633-1462.32.BJO-2021-0191.R1

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  6. Mortality and functional outcomes of fragility fractures of the pelvis by fracture type with conservative treatment: a retrospective, multicenter TRON study Reviewed International journal

    Omichi Toshifumi, Takegami Yasuhiko, Tokutake Katsuhiro, Saito Yuki, Ito Osamu, Ando Toshihiro, Imagama Shiro

    EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY     2021.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:European Journal of Trauma and Emergency Surgery  

    Purpose: Fragility fractures of the pelvis (FFP) are becoming a commonly encountered disease in aging societies. We aimed to (1) clarify the overall survival rate of FFP, (2) compare survival rates by Rommens and Hofmann classification FFP type, (3) investigate the complications during hospitalization, and (4) investigate walking ability before and after injury depending on the type of fracture in patients with FFP treated conservatively. Methods: This retrospective, multicenter study included 867 patients with FFP treated conservatively between 2014 and 2018 and excluded patients with insufficient follow-up for two years, lost data, and operative cases. This is a retrospective multicenter study. We established the database, which is named as TRON. We evaluated survival rate by fracture type using the log-rank test. We compared walking ability as defined by a new mobility score and the modified Majeed Pelvic Score among fracture types. Results: We reviewed 552 cases (98 males and 454 females) with conservative treatment. The overall survival rates of patients with FFP treated conservatively were 0.90 at 1 year and 0.83 at 2 years. Although the survival rate was the lowest in FFP Type III, there was no significant difference in survival rates between fracture types (P = 0.143). The rates of complications during hospitalization were high for both Type III and Type IV fractures. Walking ability post-injury was worse in the patients with Type III fracture. Conclusions: The survival rate of patients treated by conservative treatment was relatively good. Type III in the Rommens and Hofmann classification was related to lower life expectancy and loss of walking ability.

    DOI: 10.1007/s00068-021-01839-1

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  7. Plate fixation through the lateral extensile approach versus cannulated screw fixation through the sinus tarsi approach for calcaneal fracture: a multicenter, propensity score-matched TRON study Reviewed International journal

    Sugimoto Takuya, Tokutake Katsuhiro, Takegami Yasuhiko, Okui Nobuyuki, Kanayama Yasuhide, Inoue Hidenori, Sugimoto Ryosuke, Kagami Yujiro, Imagama Shiro

    EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY     2021.9

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:European Journal of Orthopaedic Surgery and Traumatology  

    Purpose: For calcaneal fracture, plate fixation through lateral extensive approach (LEP) is the most common procedure performed to achieve anatomic reduction. However, wound complications sometimes occur after LEP. To reduce complications, minimally invasive operative methods with cannulated screw fixation through sinus tarsi approach (STS) were developed. The aim of this multicenter propensity-matched study was to compare the clinical and radiographic outcomes of LEP to those of STS for calcaneal fracture and to evaluate the incidence of postoperative complications including surgical site infection (SSI). Methods: We extracted 271 patients with calcaneal fracture undergoing surgery between January 2014 and March 2019 from our multicenter TRON database. We assessed the American Orthopedic Foot and Ankle Society (AOFAS) score at the final follow-up as the clinical outcome. We obtained the Bohler and Preis angles as radiographic parameters and also recorded the complications. We divided the subjects into two groups: LEP group and STS group. To adjust for baseline differences between the groups, a propensity score matching algorithm was used in a 1:1 ratio. Results: After matching, there were 32 fractures in each group. There was no significant difference between the LEP versus STS group in AOFAS score at final follow-up (90 vs 90 points, p = 0.98) and in the Bohler and Pries angles (19.2 vs. 18.0 degrees, p = 0.74 and 16.0 vs. 17.5 degrees, p = 0.47). The rate of SSI in the LEP group was higher than that in the STS group (21.9% vs. 0.0%, p = 0.01). Conclusion: For calcaneal fracture, STS provides similar fixation effectiveness and functional outcomes as LEP while reducing the likelihood of infection.

    DOI: 10.1007/s00590-021-03115-9

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  8. Optimal conditions for graft survival and reinnervation of denervated muscles after embryonic motoneuron transplantation into peripheral nerves undergoing Wallerian degeneration Reviewed International journal

    Sawada Hideyoshi, Kurimoto Shigeru, Tokutake Katsuhiro, Saeki Sota, Hirata Hitoshi

    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE   Vol. 15 ( 9 ) page: 763 - 775   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Tissue Engineering and Regenerative Medicine  

    Motoneuron transplantation into peripheral nerves undergoing Wallerian degeneration may have applications in treating diseases causing muscle paralysis. We investigated whether functional reinnervation of denervated muscle could be achieved by early or delayed transplantation after denervation. Adult rats were assigned to six groups with increasing denervation periods (0, 1, 4, 8, 12, and 24 weeks) before inoculation with culture medium containing (transplantation group) or lacking (surgical control group) dissociated embryonic motoneurons into the peroneal nerve. Electrophysiological and tissue analyses were performed 3 months after transplantation. Reinnervation of denervated muscles significantly increased relative muscle weight in the transplantation group compared with the surgical control group for denervation periods of 1 week (0.042% ± 0.0031% vs. 0.032% ± 0.0020%, respectively; p = 0.009), 4 weeks (0.044% ± 0.0069% vs. 0.026% ± 0.0045%, respectively; p = 0.0023), and 8 weeks (0.044% ± 0.0029% vs. 0.026% ± 0.0008%, respectively; p = 0.0023). The ratios of reinnervated muscle contractile forces to naïve muscle in the 0, 1, 4, 8, and 12 weeks transplantation groups were 3.79%, 18.99%, 8.05%, 6.30%, and 5.80%, respectively, indicating that these forces were sufficient for walking. The optimal implantation time for transplantation of motoneurons into the peripheral nerve was 1 week after nerve transection. However, the neurons transplanted 24 weeks after denervation survived and regenerated axons. These results indicated that there is time for preparing cells for transplantation in regenerative medicine and suggested that our method may be useful for paralysed muscles that are not expected to recover with current treatment.

    DOI: 10.1002/term.3223

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  9. Does surgical treatment for unstable fragility fracture of the pelvis promote early mobilization and improve survival rate and postoperative clinical function? Reviewed International journal

    Saito Yuki, Tokutake Katsuhiro, Takegami Yasuhiko, Yoshida Masahiro, Omichi Toshifumi, Imagama Shiro

    EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY     2021.6

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:European Journal of Trauma and Emergency Surgery  

    Purpose: This retrospective multicenter study aimed to compare rates of early mobilization and survival and functional outcome of surgical treatment (S) with that of conservative treatment (C) according to each unstable fragility fracture of the pelvis (FFP) classification type with displacement of the posterior component ≥ 5 mm. Methods: We analyzed 64 patients with unstable type III and IV FFP who could move and transfer themselves before injury and had ≥ 5 mm displacement of the posterior component. We compared survival rate, early mobilization, walking ability at final follow-up, and complications at admission for each type of surgical and conservative treatment. Results: Most of the unstable FFP were type IIIa and IVb in the study population. Type III comprised 40 cases (group S:13/group C:27) and type IV comprised 24 cases (group S:7/group C:17). There were no significant differences in 3 month and 1 year survival rates, although group C (III) had the tendency of higher mortality rate (p = 0.08). Mobilization (transferring to a wheelchair) was enabled significantly earlier in group S (III) than in group C (III) (p = 0.02), but in type IV, most patients enabled early mobilization even without surgical intervention. There were no significant differences in hospital complications and walking ability at final follow-up. Conclusion: In this study, the superiority of surgical treatment for unstable FFP was not proven. However, the results suggest that type IVb may be a relatively stable type compared to type III and that type IVb should be considered separately from bilaterally complete unstable sacral fractures due to high-energy trauma.

    DOI: 10.1007/s00068-021-01729-6

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  10. Innervation of Meissner's corpuscles and Merkel -cells by transplantation of embryonic dorsal root ganglion cells after peripheral nerve section in rats Reviewed International journal

    Asano Kenichi, Nakano Tomonori, Tokutake Katsuhiro, Ishii Hisao, Nishizuka Takanobu, Iwatsuki Katsuyuki, Onishi Tetsuro, Kurimoto Shigeru, Yamamoto Michiro, Tatebe Masahiro, Hirata Hitoshi

    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE   Vol. 15 ( 6 ) page: 586 - 595   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Tissue Engineering and Regenerative Medicine  

    Transplantation of embryonic motor neurons has been shown to improve motor neuron survival and innervation of neuromuscular junctions in peripheral nerves. However, there have been no reports regarding transplantation of sensory neurons and innervation of sensory receptors. Therefore, we hypothesized that the transplantation of embryonic sensory neurons may improve sensory neurons in the skin and innervate Merkel cells and Meissner's corpuscles. We obtained sensory neurons from dorsal root ganglia of 14-day rat embryos. We generated a rat model of Wallerian-degeneration by performing sciatic nerve transection and waiting for one week after. Six months after cell transplantation, we performed histological and electrophysiological examinations in naïve control, surgical control, and cell transplantation groups. The number of nerve fibers in the papillary dermis and epidermal-dermal interface was significantly greater in the cell transplantation than in the surgical control group. The percent of Merkel cells with nerve terminals, as well as the average number of Meissner corpuscles with nerve terminals, were higher in the cell transplantation than in the surgical control group, but differences were not significant between the two groups. Moreover, the amplitude and latency of sensory conduction velocity were evoked in rats of the cell transplantation group. We demonstrated that the transplantation of embryonic dorsal root ganglion cells improved sensory nerve fiber number and innervation of Merkel cells and Meissner's corpuscles in peripheral nerves.

    DOI: 10.1002/term.3196

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  11. Primary Radial Nerve Exploration Determined by Ultrasound in Pediatric Supracondylar Humerus Fracture: A Report of Two Cases Reviewed International journal

    Tokutake Katsuhiro, Okui Nobuyuki, Hirata Hitoshi

    JOURNAL OF HAND SURGERY-ASIAN-PACIFIC VOLUME   Vol. 26 ( 02 ) page: 284 - 289   2021.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:The journal of hand surgery Asian-Pacific volume  

    We report two pediatric cases of radial nerve palsy caused by supracondylar fracture of the humerus requiring nerve exploration. The children had comparable conditions, palsy types (complete motor and partial sensory) and radiographic findings. The fracture in the first case was managed conservatively with closed reduction and percutaneous pinning but, while the patient eventually recovered from the partial sensory palsy, her motor palsy remained unchanged. In the second case, ultrasound assessment of the nerve prior to fixation indicated that surgical exploration was needed as it revealed tethering on the edge of the proximal fracture fragment. The nerve was released during an open reduction and the patient subsequently recovered from both sensory and motor palsies. Ultrasonography proved essential in the initial clinical assessment by determining how to proceed. We recommend primary nerve exploration when ultrasound findings show entrapment or tethering of the radial nerve.

    DOI: 10.1142/S2424835521720097

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  12. Visual Feedback Control of a Rat Ankle Angle Using a Wirelessly Powered Two-Channel Neurostimulator Reviewed International journal

    Takeuchi Masaru, Watanabe Keita, Ishihara Kanta, Miyamoto Taichi, Tokutake Katsuhiro, Saeki Sota, Aoyama Tadayoshi, Hasegawa Yasuhisa, Kurimoto Shigeru, Hirata Hitoshi

    SENSORS   Vol. 20 ( 8 )   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Sensors (Switzerland)  

    Peripheral nerve disconnections cause severe muscle atrophy and consequently, paralysis of limbs. Reinnervation of denervated muscle by transplanting motor neurons and applying Functional Electrical Stimulation (FES) onto peripheral nerves is an important procedure for preventing irreversible degeneration of muscle tissues. After the reinnervation of denervated muscles, multiple peripheral nerves should be stimulated independently to control joint motion and reconstruct functional movements of limbs by the FES. In this study, a wirelessly powered two-channel neurostimulator was developed with the purpose of applying selective FES to two peripheral nerves—the peroneal nerve and the tibial nerve in a rat. The neurostimulator was designed in such a way that power could be supplied wirelessly, from a transmitter coil to a receiver coil. The receiver coil was connected, in turn, to the peroneal and tibial nerves in the rat. The receiver circuit had a low pass filter to allow detection of the frequency of the transmitter signal. The stimulation of the nerves was switched according to the frequency of the transmitter signal. Dorsal/plantar flexion of the rat ankle joint was selectively induced by the developed neurostimulator. The rat ankle joint angle was controlled by changing the stimulation electrode and the stimulation current, based on the Proportional Integral (PI) control method using a visual feedback control system. This study was aimed at controlling the leg motion by stimulating the peripheral nerves using the neurostimulator.

    DOI: 10.3390/s20082210

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  13. Muscle spindle reinnervation using transplanted embryonic dorsal root ganglion cells after peripheral nerve transection in rats Reviewed International journal

    Asano Kenichi, Nakano Tomonori, Tokutake Katsuhiro, Ishii Hisao, Nishizuka Takanobu, Iwatsuki Katsuyuki, Onishi Tetsuro, Kurimoto Shigeru, Yamamoto Michiro, Tatebe Masahiro, Hirata Hitoshi

    CELL PROLIFERATION   Vol. 52 ( 5 ) page: e12660   2019.9

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    Objectives: Muscle spindles are proprioceptive receptors in the skeletal muscle. Peripheral nerve injury results in a decreased number of muscle spindles and their morphologic deterioration. However, the muscle spindles recover when skeletal muscles are reinnervated with surgical procedures, such as nerve suture or nerve transfer. Morphological changes in muscle spindles by cell transplantation procedure have not been reported so far. Therefore, we hypothesized that transplantation of embryonic sensory neurons may improve sensory neurons in the skeletal muscle and reinnervate the muscle spindles. Materials and methods: We collected sensory neurons from dorsal root ganglions of 14-day-old rat embryos and prepared a rat model of peripheral nerve injury by performing sciatic nerve transection and allowing for a period of one week before which we performed the cell transplantations. Six months later, the morphological changes of muscle spindles in the cell transplantation group were compared with the naïve control and surgical control groups. Results: Our results demonstrated that transplantation of embryonic dorsal root ganglion cells induced regeneration of sensory nerve fibre and reinnervation of muscle spindles in the skeletal muscle. Moreover, calbindin D-28k immunoreactivity in intrafusal muscle fibres was maintained for six months after denervation in the cell transplantation group, whereas it disappeared in the surgical control group. Conclusions: Cell transplantation therapies could serve as selective targets to modulate mechanosensory function in the skeletal muscle.

    DOI: 10.1111/cpr.12660

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  14. Usefulness of CT-based measurement of volar prominence for evaluation of risk of flexor tendon injury following fixation of a distal radius fracture Reviewed International journal

    Tokutake Katsuhiro, Iwatsuki Katsuyuki, Tatebe Masahiro, Okui Nobuyuki, Mizuno Masanori, Hirata Hitoshi

    JOURNAL OF ORTHOPAEDIC SCIENCE   Vol. 24 ( 2 ) page: 263 - 268   2019.3

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Orthopaedic Science  

    Background: Although some radiographic evaluations of the risk of flexor tendon injury following fixation of a distal radius fracture are useful, these radiographic measurements are limited because of their inability to obtain three-dimensional measurements. We hypothesized that CT-based measurements would be more sensitive indicators for risk estimation than radiography. Methods: We retrospectively evaluated the relationship between plate positioning and the incidence of flexor tendon symptoms based on postoperative radiographic and CT-based measurements in 99 hands that were followed up for more than 12 months. We also compared the reproducibility, diagnostic accuracy, and ability to detect the plate-bone gap between radiographic and CT-based measurements. We also assessed the correlation between the volar prominence and plate-bone gap using CT. Multivariable analysis using stepwise logistic regression was performed to identify factors independently associated with tendon rupture or irritation. Results: In single variable analysis, we found that the volar tilt was significantly smaller and the radiographic plate-to-critical line distance (PCL), CT-PCL, and CT-gap were significantly greater in the group with tendon irritation or rupture. Multivariable logistic regression analysis indicated that the CT-based measurement of the volar prominence is a significantly positive independent predictor of tendon rupture or irritation. Conclusion: CT-based measurement of the volar prominence may be one of the best radiographic predictors of the risk of flexor tendon injury following fixation of a distal radius fracture regardless of the plate type and distal prominence and the extent of rotation. This measurement may assist surgeons when deciding on the need for removal of hardware to decrease the long-term risk of flexor tendon rupture.

    DOI: 10.1016/j.jos.2018.08.021

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  15. Comparison of functional outcome and complications of locking plate versus coracoclavicular fixation in the treatment of unstable distal clavicle fractures: the multicenter, propensity-matched TRON study Reviewed

    Katayama Yujiro, Takegami Yasuhiko, Tokutake Katsuhiro, Okui Nobuyuki, Sakai Tadahiro, Takahashi Hiroshi, Imagama Shiro

    EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY     2022.8

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  16. The Association of Bohler's Angle With Postoperative Pain and Gender for Displaced Intra-Articular Calcaneal Fracture, Multicenter Retrospective Study-TRON Study. Reviewed International journal

    Sugimoto R, Tokutake K, Takegami Y, Kanayama Y, Okui N, Sakai T, Kagami Y, Sugimoto T, Imagama S

    The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons   Vol. 61 ( 4 ) page: 766 - 770   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Foot and Ankle Surgery  

    A relationship between Böhler angle (BA) before or after surgery and clinical outcomes remains unclear. This retrospective multicenter cohort study aimed to compare pain and functional outcomes between a group in which the reduction angle was preserved and a group in which the reduction angle was lost during follow-up, and to clarify the risk factors leading to loss of last follow-up BA. From 2014 to 2018, 271 cases of calcaneal fractures were surgically treated at ten facilities. We divided patients into Group L (lost reduction of fracture) and Group P (preserved reduction of fracture). We matched subjects between the 2 groups according to age, sex and BA before surgery and compared American Orthopedic Foot and Ankle Society (AOFAS) score between the groups. We investigated the correlation between the amount of BA loss and postoperative pain. The factors leading to loss of last follow-up BA were examined by logistic regression analysis. Ultimately, 112 patients were eligible. After matching, each group included 38 patients. There was no difference between the 2 groups in total AOFAS score. However, the pain component of AOFAS score at 6 months and 12 months were worse in group L than in group P (p = .011, p = .031, respectively). We also showed a weak correlation between the amount of BA loss and postoperative pain. Logistic regression analysis revealed that female and BA before surgery independently predicted loss of reduction (odds ratios: 4.66, 95% CI: 1.15-18.9 and odds ratios: 0.90, 95% CI: 0.82-0.99, respectively). We clarified that reduction and preservation of BA within its normal range should lead to decrease postoperative pain. Female and lower pre-BA were risk factors leading to loss of reduction of BA in operative treatment of calcaneal fractures.

    DOI: 10.1053/j.jfas.2021.11.011

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  17. Risk factors for fracture-related infection after open reduction and internal fixation of proximal humerus fractures: A multicenter retrospective study of 496 fractures (TRON group study). Reviewed

    Makihara K, Takegami Y, Tokutake K, Yamauchi K, Hiramatsu Y, Matsuura Y, Imagama S

    Injury   Vol. 53 ( 7 ) page: 2573 - 2578   2022.7

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    Introduction: One of the complications of the surgical therapy for proximal humerus fractures is fracture-related infection (FRI). This multicenter study aimed to investigate the incidence of FRI and clarify the risk factors associated with FRI in patients receiving open reduction and internal fixation for proximal humerus fracture. Material and methods: Among 684 patients diagnosed as having proximal humerus fracture and who were treated by surgical therapy in 13 institutions (named TRON group) from 2015 through 2020, 496 patients (men, n = 134, women, n = 362; mean [SD] age, 68.5 [14.5] years; mean [SD] body mass index [BMI], 23.0 [4.4] kg/m2) were included as subjects. Excluded were 188 patients due to less than 12 month's follow-up, patients who underwent osteosynthesis using neither plate nor nail and those with open fracture. We extracted the following as risk factors of FRI: sex, BMI, smoking status, diabetes, glenohumeral fracture dislocation, fracture classification, approach, implant, waiting period, type of anesthesia, operative time and blood loss during surgery. We conducted logistic regression analysis to investigate the risk factors of FRI using these extracted items as explanatory variables and the presence or absence of FRI as the response variable. Result: FRI occurred after surgery for proximal humerus fracture in 9 of the 496 patients (1.8%). The causative organism was methicillin-susceptible Staphylococcus aureus in 4 patients, Pseudomonas aeruginosa in one patient and Enterococcus faecalis in one patient. In the other 3 patients, causative organisms were not detected. The univariate analysis showed significant differences for present of glenohumeral fracture dislocation (p = 0.004). Logistic regression analysis showed glenohumeral fracture dislocation to be the significant explanatory factor for FRI (odds ratio 12.3, p = 0.0375). Conclusion: This study revealed an infection rate following open reduction and internal fixation of proximal humerus fracture of 1.8% (9 patients) and that Staphylococcus was the most frequent causative organism. Glenohumeral fracture dislocation is a significant risk for postoperative FRI.

    DOI: 10.1016/j.injury.2022.05.022

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  18. Displaced humeral head after intramedullary nailing for proximal humeral fracture is associated with worse short-term outcomes-a multicenter TRON study. Reviewed

    Hiramatsu Y, Takegami Y, Katsuhiro T, Matsuura Y, Makihara K, Kanemura T, Imagama S

    JSES international   Vol. 6 ( 3 ) page: 374 - 379   2022.5

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    DOI: 10.1016/j.jseint.2021.12.009

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  19. Association between C8 brachial plexus injury and rib fracture following median sternotomy Reviewed

    TOKUTAKE Katsuhiro

    The Central Japan Journal of Orthopaedic Surgery & Traumatology   Vol. 64 ( 5 ) page: 677 - 678   2021.9

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    Language:Japanese   Publisher:THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY  

    DOI: 10.11359/chubu.2021.677

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  20. Two cases of ganglion cyst of the hallux Reviewed

    HOSOKAWA Yuta

    The Central Japan Journal of Orthopaedic Surgery & Traumatology   Vol. 61 ( 5 ) page: 1017 - 1018   2018.9

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    Language:Japanese   Publisher:THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY  

    DOI: 10.11359/chubu.2018.1017

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MISC 2

  1. Association between C8 brachial plexus injury and rib fracture following median sternotomy

    TOKUTAKE Katsuhiro

    The Central Japan Journal of Orthopaedic Surgery & Traumatology   Vol. 64 ( 5 ) page: 677 - 678   2021.9

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    Language:Japanese   Publisher:THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY  

    DOI: 10.11359/chubu.2021.677

    CiNii Research

  2. Two cases of ganglion cyst of the hallux

    HOSOKAWA Yuta

    The Central Japan Journal of Orthopaedic Surgery & Traumatology   Vol. 61 ( 5 ) page: 1017 - 1018   2018.9

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    Language:Japanese   Publisher:THE CENTRAL JAPAN ASSOCIATION OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY  

    DOI: 10.11359/chubu.2018.1017

    CiNii Research

KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. Sensorimotor Control System with Ectopic Ganglion Induction

    Grant number:22H03451  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  2. Reconstruction of Motor Function by Regenerative Medicine and Implantable Neurostimulator Device for Overcoming Intractable Paralysis

    Grant number:20K17997  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

  3. 肥満細胞が狭窄性腱鞘炎発症に与える影響の解明と新薬開発への応用

    Grant number:21K09275  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(C)

    仲野 隆彦, 栗本 秀, 平田 仁, 徳武 克浩

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    Authorship:Coinvestigator(s) 

  4. Development of An Implantable Electrical Stimulation Device towards Reconstructing Functional Motions

    Grant number:21H01290  2021.4 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Competitive