Updated on 2022/03/31

写真a

 
KIYONAKA Shigeki
 
Organization
Graduate School of Engineering Biomolecular Engineering 2 Professor
Graduate School
Graduate School of Engineering
Undergraduate School
School of Engineering Chemistry and Biotechnology
Title
Professor

Degree 1

  1. 博士(工学) ( 2002.11   九州大学 ) 

Research Areas 3

  1. Nanotechnology/Materials / Bio chemistry

  2. Life Science / Neuroscience-general

  3. Life Science / Bioorganic chemistry

Research History 4

  1. Nagoya University   Professor

    2019.3

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    Country:Japan

  2. Kyoto University

    2011.4 - 2016.3

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    Country:Japan

  3. Kyoto University   Associate professor

    2010.8 - 2019.2

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    Country:Japan

  4. 京都大学 工学研究科   助手

    2005 - 2006

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    Country:Japan

Education 1

  1. Kyushu University   Graduate School, Division of Engineering

    - 2002

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    Country: Japan

Professional Memberships 5

  1. 日本化学会

  2. 日本神経科学会

  3. 日本薬理学会

  4. 日本生化学会

  5. アメリカ化学会

 

Papers 23

  1. Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches Invited Reviewed International journal

    Miura Yuta, Senoo Akinobu, Doura Tomohiro, Kiyonaka Shigeki

    RSC CHEMICAL BIOLOGY   Vol. 3 ( 3 ) page: 269 - 287   2022.3

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d1cb00195g

    Web of Science

  2. Orthogonal Activation of Metabotropic Glutamate Receptor Using Coordination Chemogenetics Invited Reviewed International journal

    Senoo Akinobu, Yamada Yutaro, Ojima Kento, Doura Tomohiro, Hamachi Itaru, Kiyonaka Shigeki

    FRONTIERS IN CHEMISTRY   Vol. 9   page: 825669   2022.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fchem.2021.825669

    Web of Science

    PubMed

  3. Tethering-based chemogenetic approaches for the modulation of protein function in live cells Reviewed International coauthorship International journal

    Tsai Yu-Hsuan, Doura Tomohiro, Kiyonaka Shigeki

    CHEMICAL SOCIETY REVIEWS   Vol. 50 ( 14 ) page: 7909 - 7923   2021.7

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d1cs00059d

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    PubMed

  4. Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking Reviewed International journal

    Ojima Kento, Shiraiwa Kazuki, Soga Kyohei, Doura Tomohiro, Takato Mikiko, Komatsu Kazuhiro, Yuzaki Michisuke, Hamachi Itaru, Kiyonaka Shigeki

    NATURE COMMUNICATIONS   Vol. 12 ( 1 ) page: 831   2021.2

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Nature Communications  

    DOI: 10.1038/s41467-021-21082-x

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  5. Construction of a Fluorescent Screening System of Allosteric Modulators for the GABA(A) Receptor Using a Turn-On Probe Reviewed International journal

    Sakamoto Seiji, Yamaura Kei, Numata Tomohiro, Harada Fumio, Amaike Kazuma, Inoue Ryuji, Kiyonaka Shigeki, Hamachi Itaru

    ACS CENTRAL SCIENCE   Vol. 5 ( 9 ) page: 1541 - 1553   2019.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acscentsci.9b00539

    Web of Science

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  6. Construction of ligand assay systems by protein-based semisynthetic biosensors. Invited Reviewed International journal

    Sakamoto S, Kiyonaka S, Hamachi I

    Current opinion in chemical biology   Vol. 50   page: 10 - 18   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cbpa.2019.02.011

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  7. Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons. Reviewed International coauthorship International journal

    Ha HTT, Leal-Ortiz S, Lalwani K, Kiyonaka S, Hamachi I, Mysore SP, Montgomery JM, Garner CC, Huguenard JR, Kim SA

    Frontiers in molecular neuroscience   Vol. 11   page: 405   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fnmol.2018.00405

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  8. Chemogenetic Approach Using Ni(II) Complex-Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors. Reviewed International journal

    Kubota R, Nomura W, Iwasaka T, Ojima K, Kiyonaka S, Hamachi I

    ACS central science   Vol. 4 ( 9 ) page: 1211 - 1221   2018.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acscentsci.8b00390

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  9. Ligand-Directed Chemistry of AMPA Receptors Confers Live-Cell Fluorescent Biosensors. Reviewed International journal

    Kiyonaka S, Sakamoto S, Wakayama S, Morikawa Y, Tsujikawa M, Hamachi I

    ACS chemical biology   Vol. 13 ( 7 ) page: 1880 - 1889   2018.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acschembio.7b01042

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  10. Intracellular thermometry with fluorescent sensors for thermal biology. Invited Reviewed International journal

    Okabe K, Sakaguchi R, Shi B, Kiyonaka S

    Pflugers Archiv : European journal of physiology   Vol. 470 ( 5 ) page: 717 - 731   2018.5

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00424-018-2113-4

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  11. DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K<sup>+</sup> Channels. Reviewed International journal

    Kurokawa T, Kiyonaka S, Nakata E, Endo M, Koyama S, Mori E, Tran NH, Dinh H, Suzuki Y, Hidaka K, Kawata M, Sato C, Sugiyama H, Morii T, Mori Y

    Angewandte Chemie (International ed. in English)   Vol. 57 ( 10 ) page: 2586 - 2591   2018.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201709982

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  12. Affinity-Guided Oxime Chemistry for Selective Protein Acylation in Live Tissue Systems. Reviewed International journal

    Tamura T, Song Z, Amaike K, Lee S, Yin S, Kiyonaka S, Hamachi I

    Journal of the American Chemical Society   Vol. 139 ( 40 ) page: 14181 - 14191   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.7b07339

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  13. Chemical labelling for visualizing native AMPA receptors in live neurons. Reviewed International journal

    Wakayama S, Kiyonaka S, Arai I, Kakegawa W, Matsuda S, Ibata K, Nemoto YL, Kusumi A, Yuzaki M, Hamachi I

    Nature communications   Vol. 8   page: 14850   2017.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms14850

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  14. Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry. Reviewed International journal

    Yamaura K, Kiyonaka S, Numata T, Inoue R, Hamachi I.

    Nature Chemical Biology   Vol. 12 ( 10 ) page: 822 - +   2016.10

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/NCHEMBIO.2150

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  15. Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells. Reviewed International journal

    Kiyonaka S, Kubota R, Michibata Y, Sakakura M, Takahashi H, Numata T, Inoue R, Yuzaki M, Hamachi I

    Nature Chemistry   Vol. 8 ( 10 ) page: 958 - 967   2016.10

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/NCHEM.2554

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  16. A Set of Organelle-Localizable Reactive Molecules for Mitochondrial Chemical Proteomics in Living Cells and Brain Tissues. Reviewed International journal

    Yasueda Y, Tamura T, Fujisawa A, Kuwata K, Tsukiji S, Kiyonaka S, Hamachi I.

    J. Am. Chem. Soc.   Vol. 138 ( 24 ) page: 7592 - 7602   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.6b02254

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  17. On-cell coordination chemistry: Chemogenetic activation of membrane-bound glutamate receptors in living cells. Reviewed

    Kubota R, Kiyonaka S, Hamachi I

    Methods in enzymology   Vol. 622   page: 411-430   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/bs.mie.2019.02.033

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  18. Molecular Technologies in Life Innovation: Novel Molecular Technologies for Labeling and Functional Control of Proteins Under Live Cell Conditions

    Hamachi Itaru, Kiyonaka Shigeki, Tamura Tomonori, Kubota Ryou

    MOLECULAR TECHNOLOGY, VOL 2: LIFE INNOVATION     page: 297 - 328   2018

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    Web of Science

  19. Construction of Protein-Based Biosensors Using Ligand-Directed Chemistry for Detecting Analyte Binding.

    Yamaura K, Kiyonaka S, Hamachi I

    Methods in enzymology   Vol. 589   page: 253-280   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/bs.mie.2017.02.006

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  20. TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O<sub>2</sub> sensing.

    Mori Y, Takahashi N, Kurokawa T, Kiyonaka S

    Proceedings of the Japan Academy. Series B, Physical and biological sciences   Vol. 93 ( 7 ) page: 464-482   2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2183/pjab.93.028

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  21. A conditional proteomics approach to identify proteins involved in zinc homeostasis. Reviewed

    Miki T, Awa M, Nishikawa Y, Kiyonaka S, Wakabayashi M, Ishihama Y, Hamachi I

    Nature Methods   Vol. 13 ( 11 ) page: 931-937   2016.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nmeth.3998.

  22. Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling Reviewed

    Nagamori Shushi, Wiriyasermkul Pattama, Okuda Suguru, Kojima Naoto, Hari Yoshiyuki, Kiyonaka Shigeki, Mori Yasuo, Tominaga Hideyuki, Ohgaki Ryuichi, Kanai Yoshikatsu

    AMINO ACIDS   Vol. 48 ( 4 ) page: 1045-1058   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00726-015-2158-z

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  23. Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds Reviewed

    Sawamura Seishiro, Hatano Masahiko, Takada Yoshinori, Hino Kyosuke, Kawamura Tetsuya, Tanikawa Jun, Nakagawa Hiroshi, Hase Hideharu, Nakao Akito, Hirano Mitsuru, Rotrattanadumrong Rachapun, Kiyonaka Shigeki, Mori Masayuki X., Nishida Motohiro, Hu Yaopeng, Inoue Ryuji, Nagata Ryu, Mori Yasuo

    MOLECULAR PHARMACOLOGY   Vol. 89 ( 3 ) page: 348-363   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1124/mol.115.102863

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Presentations 18

  1. グルタミン受容体動態の定量解析を目指した新たなケミカルラベル Invited

    清中 茂樹

    日本化学会第101春季年会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

  2. 酸素感受性イオンチャネルTRPA1の動態解析に向けたcpHalo-tagラベル

    杉原 佑太朗、曽我 恭平、森 泰生、清中 茂樹

    日本化学会第101春季年会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  3. 細胞外ループ工学によるGPCR化学遺伝学(2): ECL3に着目したアデノシン受容体の活性制御

    松岡 佑真、杓野 拓光、堂浦 智裕、清中 茂樹

    日本化学会第101春季年会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  4. リガンド指向性化学と逆電子要請型Diels-Alder(IEDDA)反応を組み合わせたリガンド指向性2段階ラベル化法の開発

    曽我 恭平、小島 憲人、浜地 格、清中 茂樹

    日本化学会第101春季年会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  5. 細胞外ループ工学によるGPCR化学遺伝学(3): アロステリックサイトに着目した代謝型グルタミン酸受容体の活性制御

    堂浦 智裕、長谷川 寛太、清中 茂樹

    日本化学会第101春季年会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  6. 細胞外ループ工学によるGPCR化学遺伝学(1):ECL2に着目したヒスタミン受容体の活性制御

    柏 俊太朗、堂浦 智裕、清中 茂樹

    日本化学会第101春季年会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  7. DNA修復部位の可視化・制御機構解明を目指した蛍光タンパク質プローブの開発

    深田 梨沙子、神谷 凌、小川 大輝、金岡 英徳、清中 茂樹

    日本化学会第101春季年会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  8. 新たな配位ケモジェネティクス(1): タンパク質構造変化の干渉に基づくグルタミン酸受容体の活性制御法開発

    三浦 裕太、小島 憲人、浜地 格、清中 茂樹

    日本化学会第101春季年会  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  9. Ligand-directed two-step labeling to quantify AMPA-type glutamate receptor trafficking

    Kento Ojima,Kyohei Soga, Itaru Hamachi, Shigeki Kiyonaka

    2021.3 

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    Event date: 2021.3

    Language:English   Presentation type:Oral presentation (general)  

  10. DNA修復機構解明を目指した分割蛍光タンパク質プローブによる細胞内イメージング

    深田 梨沙子、小川 大輝、神谷 凌、金岡 英徳、清中 茂樹

    iACEシンポジウム2021  2021.3 

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    Event date: 2021.3

    Language:Japanese   Presentation type:Oral presentation (general)  

  11. リガンド指向性化学を用いた2段階ラベル化戦略によるAMPA受容体の動態解析

    小島 憲人、浜地 格、清中 茂樹

    生理研研究会「シナプス研究会」  2020.12 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Poster presentation  

  12. DNA二重鎖切断修復でのfoci形成におけるSUMOタンパク質の機能解明

    深田 梨沙子、小川 大輝、神谷 凌、金岡 英徳、清中 茂樹

    第43回日本分子生物学会年会  2020.12 

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    Event date: 2020.12

    Language:Japanese   Presentation type:Poster presentation  

  13. 代謝型グルタミン酸受容体のin vivo活性制御を指向した新たな化学遺伝学的手法の開発

    堂浦 智裕、長谷川 寛太、清中 茂樹

    第14回バイオ関連化学シンポジウム  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  14. 配位ケモジェネティクスによる GABAB 受容体のアロステリック活性化

    曽我 恭平、小島 憲人、道旗 友紀子、浜地 格、清中 茂樹

    第14回バイオ関連化学シンポジウム  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Poster presentation  

    Venue:オンライン  

  15. 配位ケモジェネティクスによる細胞種・サブタイプ選択的なグルタミン酸受容体の活性阻害法開発

    三浦 裕太、小島 憲人、美野 丈晴、浜地 格、清中 茂樹

    第14回バイオ関連化学シンポジウム  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Poster presentation  

  16. 細胞種直交的活性化に向けた受容体エンジニアリング法の開発

    山田 裕太郎、小島 憲人、浜地 格、清中 茂樹

    第14回バイオ関連化学シンポジウム  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Poster presentation  

  17. 代謝型グルタミン酸受容体の細胞外ループに注目した新たな化学遺伝学手法の開発

    長谷川 寛太、堂浦 智裕、清中 茂樹

    第14回バイオ関連化学シンポジウム  2020.9 

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    Event date: 2020.9

    Language:Japanese   Presentation type:Poster presentation  

  18. 神経伝達物質受容体の機能を解き明かすためのニューロケミカルバイオロジー Invited

    清中 茂樹

    第44回白金シンポジウム  2020.2 

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    Event date: 2020.2

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

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Industrial property rights 1

  1. 変異型Gタンパク質共役型受容体

    清中茂樹、堂浦智裕、長谷川寛太

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    Applicant:国立大学法人名古屋大学

    Application no:特願2020-033798  Date applied:2020.2