日本生理学会

日本ケミカルバイオロジー学会

Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue

Ojima, K; Kakegawa, W; Yamasaki, T; Miura, Y; Itoh, M; Michibata, Y; Kubota, R; Doura, T; Miura, E; Nonaka, H; Mizuno, S; Takahashi, S; Yuzaki, M; Hamachi, I; Kiyonaka, S

NATURE COMMUNICATIONS   Vol. 13 ( 1 ) page： 3167   2022.6

Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches International journal

Miura, Y; Senoo, A; Doura, T; Kiyonaka, S

RSC CHEMICAL BIOLOGY   Vol. 3 ( 3 ) page： 269 - 287   2022.3

Superresolution imaging of native surface AMPA receptors in brain tissue

Vaidya, R; Kiyonaka, S; Hamachi, I; Chung, HJ; Selvin, PR

BIOPHYSICAL JOURNAL   Vol. 121 ( 3 ) page： 271A - 272A   2022.2

Orthogonal Activation of Metabotropic Glutamate Receptor Using Coordination Chemogenetics International journal

Senoo, A; Yamada, Y; Ojima, K; Doura, T; Hamachi, I; Kiyonaka, S

FRONTIERS IN CHEMISTRY   Vol. 9   page： 825669   2022.1

Frontier of Photopharmacology for High-speed Molecular Movies of Proteins Foreword

Nagasawa, H; Kiyonaka, S

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   Vol. 142 ( 5 ) page： 477 - 478   2022

Tethering-based chemogenetic approaches for the modulation of protein function in live cells International coauthorship International journal

Tsai, YH; Doura, T; Kiyonaka, S

CHEMICAL SOCIETY REVIEWS   Vol. 50 ( 14 ) page： 7909 - 7923   2021.7

Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking International journal

Ojima, K; Shiraiwa, K; Soga, K; Doura, T; Takato, M; Komatsu, K; Yuzaki, M; Hamachi, I; Kiyonaka, S

NATURE COMMUNICATIONS   Vol. 12 ( 1 ) page： 831   2021.2

Construction of a Fluorescent Screening System of Allosteric Modulators for the GABA(A) Receptor Using a Turn-On Probe International journal

Sakamoto Seiji, Yamaura Kei, Numata Tomohiro, Harada Fumio, Amaike Kazuma, Inoue Ryuji, Kiyonaka Shigeki, Hamachi Itaru

ACS CENTRAL SCIENCE   Vol. 5 ( 9 ) page： 1541 - 1553   2019.9

Construction of ligand assay systems by protein-based semisynthetic biosensors. International journal

Sakamoto S, Kiyonaka S, Hamachi I

Current opinion in chemical biology   Vol. 50   page： 10 - 18   2019.6

On-cell coordination chemistry: Chemogenetic activation of membrane-bound glutamate receptors in living cells.

Kubota R, Kiyonaka S, Hamachi I

Methods in enzymology   Vol. 622   page： 411 - 430   2019

Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons. International coauthorship International journal

Ha HTT, Leal-Ortiz S, Lalwani K, Kiyonaka S, Hamachi I, Mysore SP, Montgomery JM, Garner CC, Huguenard JR, Kim SA

Frontiers in molecular neuroscience   Vol. 11   page： 405   2018.11

Chemogenetic Approach Using Ni(II) Complex-Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors. International journal

Kubota R, Nomura W, Iwasaka T, Ojima K, Kiyonaka S, Hamachi I

ACS central science   Vol. 4 ( 9 ) page： 1211 - 1221   2018.9

Ligand-Directed Chemistry of AMPA Receptors Confers Live-Cell Fluorescent Biosensors. International journal

Kiyonaka S, Sakamoto S, Wakayama S, Morikawa Y, Tsujikawa M, Hamachi I

ACS chemical biology   Vol. 13 ( 7 ) page： 1880 - 1889   2018.7

Intracellular thermometry with fluorescent sensors for thermal biology. International journal

Okabe K, Sakaguchi R, Shi B, Kiyonaka S

Pflugers Archiv : European journal of physiology   Vol. 470 ( 5 ) page： 717 - 731   2018.5

DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K⁺ Channels. International journal

Kurokawa T, Kiyonaka S, Nakata E, Endo M, Koyama S, Mori E, Tran NH, Dinh H, Suzuki Y, Hidaka K, Kawata M, Sato C, Sugiyama H, Morii T, Mori Y

Angewandte Chemie (International ed. in English)   Vol. 57 ( 10 ) page： 2586 - 2591   2018.3

Molecular Technologies in Life Innovation: Novel Molecular Technologies for Labeling and Functional Control of Proteins Under Live Cell Conditions

Hamachi, I; Kiyonaka, S; Tamura, T; Kubota, R

MOLECULAR TECHNOLOGY, VOL 2: LIFE INNOVATION     page： 297 - 328   2018

Affinity-Guided Oxime Chemistry for Selective Protein Acylation in Live Tissue Systems. International journal

Tamura T, Song Z, Amaike K, Lee S, Yin S, Kiyonaka S, Hamachi I

Journal of the American Chemical Society   Vol. 139 ( 40 ) page： 14181 - 14191   2017.10

TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O₂ sensing.

Mori Y, Takahashi N, Kurokawa T, Kiyonaka S

Proceedings of the Japan Academy. Series B, Physical and biological sciences   Vol. 93 ( 7 ) page： 464 - 482   2017.7

Chemical labelling for visualizing native AMPA receptors in live neurons. International journal

Wakayama S, Kiyonaka S, Arai I, Kakegawa W, Matsuda S, Ibata K, Nemoto YL, Kusumi A, Yuzaki M, Hamachi I

Nature communications   Vol. 8   page： 14850   2017.4

Construction of Protein-Based Biosensors Using Ligand-Directed Chemistry for Detecting Analyte Binding.

Yamaura K, Kiyonaka S, Hamachi I

Methods in enzymology   Vol. 589   page： 253 - 280   2017

A conditional proteomics approach to identify proteins involved in zinc homeostasis

Miki, T; Awa, M; Nishikawa, Y; Kiyonaka, S; Wakabayashi, M; Ishihama, Y; Hamachi, I

NATURE METHODS   Vol. 13 ( 11 ) page： 931 - +   2016.11

Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry. International journal

Yamaura K, Kiyonaka S, Numata T, Inoue R, Hamachi I.

Nature Chemical Biology   Vol. 12 ( 10 ) page： 822 - +   2016.10

Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells. International journal

Kiyonaka S, Kubota R, Michibata Y, Sakakura M, Takahashi H, Numata T, Inoue R, Yuzaki M, Hamachi I

Nature Chemistry   Vol. 8 ( 10 ) page： 958 - 967   2016.10

A Set of Organelle-Localizable Reactive Molecules for Mitochondrial Chemical Proteomics in Living Cells and Brain Tissues. International journal

Yasueda Y, Tamura T, Fujisawa A, Kuwata K, Tsukiji S, Kiyonaka S, Hamachi I.

J. Am. Chem. Soc.   Vol. 138 ( 24 ) page： 7592 - 7602   2016.6

Structure-activity relations of leucine derivatives reveal critical moieties for cellular uptake and activation of mTORC1-mediated signaling

Nagamori Shushi, Wiriyasermkul Pattama, Okuda Suguru, Kojima Naoto, Hari Yoshiyuki, Kiyonaka Shigeki, Mori Yasuo, Tominaga Hideyuki, Ohgaki Ryuichi, Kanai Yoshikatsu

AMINO ACIDS   Vol. 48 ( 4 ) page： 1045 - 1058   2016.4

Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds

Sawamura Seishiro, Hatano Masahiko, Takada Yoshinori, Hino Kyosuke, Kawamura Tetsuya, Tanikawa Jun, Nakagawa Hiroshi, Hase Hideharu, Nakao Akito, Hirano Mitsuru, Rotrattanadumrong Rachapun, Kiyonaka Shigeki, Mori Masayuki X., Nishida Motohiro, Hu Yaopeng, Inoue Ryuji, Nagata Ryu, Mori Yasuo

MOLECULAR PHARMACOLOGY   Vol. 89 ( 3 ) page： 348 - 363   2016.3

[Next-Generation Chemogenetics for Elucidating Higher Brain Functions].

Matsuoka Y, Kashiwa S, Doura T, Kiyonaka S

Brain and nerve = Shinkei kenkyu no shinpo   Vol. 75 ( 4 ) page： 367 - 374   2023.4

Probing synaptic distribution and arrangement of native surface AMPAR in mouse brain slices with 3D super-resolution microscopy International coauthorship International journal

Vaidya, RM; Nall, DL; Ma, DH; Huang, F; Kiyonaka, S; Hamachi, I; Chung, HJ; Selvin, PR

BIOPHYSICAL JOURNAL   Vol. 122 ( 3 ) page： 417A - 417A   2023.2

Revisiting PFA-mediated tissue fixation chemistry:<i> FixEL</i> enables trapping of small molecules in the brain to visualize their distribution changes Reviewed International journal

Nonaka, H; Mino, T; Sakamoto, S; Oh, JH; Watanabe, Y; Ishikawa, M; Tsushima, A; Amaike, K; Kiyonaka, S; Tamura, T; Aricescu, AR; Kakegawa, W; Miura, E; Yuzaki, M; Hamachi, I

CHEM   Vol. 9 ( 2 ) page： 523 - 540   2023.2

A conditional proteomics approach to identify proteins involved in zinc homeostasis. Reviewed

Miki T, Awa M, Nishikawa Y, Kiyonaka S, Wakabayashi M, Ishihama Y, Hamachi I

Nature Methods   Vol. 13 ( 11 ) page： 931-937   2016.10

細胞外ループ工学によるGPCR化学遺伝学(1)：ECL2に着目したヒスタミン受容体の活性制御

柏 俊太朗、堂浦 智裕、清中 茂樹

日本化学会第101春季年会  2021.3 

DNA修復部位の可視化・制御機構解明を目指した蛍光タンパク質プローブの開発

深田 梨沙子、神谷 凌、小川 大輝、金岡 英徳、清中 茂樹

日本化学会第101春季年会  2021.3 

新たな配位ケモジェネティクス(1): タンパク質構造変化の干渉に基づくグルタミン酸受容体の活性制御法開発

三浦 裕太、小島 憲人、浜地 格、清中 茂樹

日本化学会第101春季年会  2021.3 

Ligand-directed two-step labeling to quantify AMPA-type glutamate receptor trafficking

Kento Ojima,Kyohei Soga, Itaru Hamachi, Shigeki Kiyonaka

2021.3 

DNA修復機構解明を目指した分割蛍光タンパク質プローブによる細胞内イメージング

深田 梨沙子、小川 大輝、神谷 凌、金岡 英徳、清中 茂樹

iACEシンポジウム2021  2021.3 

リガンド指向性化学を用いた2段階ラベル化戦略によるAMPA受容体の動態解析

小島　憲人、浜地　格、清中　茂樹

生理研研究会「シナプス研究会」  2020.12 

DNA二重鎖切断修復でのfoci形成におけるSUMOタンパク質の機能解明

深田 梨沙子、小川 大輝、神谷 凌、金岡 英徳、清中 茂樹

第43回日本分子生物学会年会  2020.12 

代謝型グルタミン酸受容体のin vivo活性制御を指向した新たな化学遺伝学的手法の開発

堂浦 智裕、長谷川 寛太、清中 茂樹

第14回バイオ関連化学シンポジウム  2020.9 

配位ケモジェネティクスによる GABAB 受容体のアロステリック活性化

曽我 恭平、小島 憲人、道旗 友紀子、浜地 格、清中 茂樹

第14回バイオ関連化学シンポジウム  2020.9 

配位ケモジェネティクスによる細胞種・サブタイプ選択的なグルタミン酸受容体の活性阻害法開発

三浦 裕太、小島 憲人、美野 丈晴、浜地 格、清中 茂樹

第14回バイオ関連化学シンポジウム  2020.9 

細胞種直交的活性化に向けた受容体エンジニアリング法の開発

山田 裕太郎、小島 憲人、浜地 格、清中 茂樹

第14回バイオ関連化学シンポジウム  2020.9 

代謝型グルタミン酸受容体の細胞外ループに注目した新たな化学遺伝学手法の開発

長谷川 寛太、堂浦 智裕、清中 茂樹

第14回バイオ関連化学シンポジウム  2020.9 

神経伝達物質受容体の機能を解き明かすためのニューロケミカルバイオロジー Invited

清中 茂樹

第４４回白金シンポジウム  2020.2