研究者詳細 - 田村　高志

論文 - 田村　高志

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Association between Dietary Patterns and Serum Low Density Lipoprotein Cholesterol in Japanese Women and Men: The Japan Multi-Institutional Collaborative Cohort (J-MICC) Study 査読有り

Kitaoka, K; Miura, K; Takashima, N; Kadota, A; Harada, A; Nakamura, Y; Kita, Y; Yano, Y; Tamura, T; Nagayoshi, M; Okada, R; Kubo, Y; Suzuki, S; Nishiyama, T; Tanoue, S; Koriyama, C; Kuriki, K; Arisawa, K; Katsuura-Kamano, S; Nishida, Y; Shimanoe, C; Ozaki, E; Matsui, D; Ikezaki, H; Otonari, J; Oze, I; Koyanagi, YN; Nakamura, Y; Kusakabe, M; Wakai, K; Matsuo, K

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 30 巻 ( 10 ) 頁： 1427 - 1447 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aims: The association between dietary patterns and serum low density lipoprotein (LDL) cholesterol would be changing in recent dietary habits in Japan. We investigated the relationship between dietary patterns and serum LDL cholesterol in a large general population. Methods: From the baseline survey of Japan Multi-Institutional Collaborative Cohort Study between 2005 and 2013, 27,237 participants (13,994 were women) aged 35–69 years were cross-sectionally analyzed. Using a semi-quantitative food frequency questionnaire, five major sex-specific dietary patterns were identified using factor analysis. We assessed serum LDL cholesterol by quintiles of dietary pattern factor score. Results: We identified dietary patterns; “vegetable rich pattern”, “meat and fried food rich pattern” and “high bread and low rice pattern” in women and men; “fish and shellfish rich pattern” and “high confectioneries and low alcohol pattern” in men; “healthy Japanese diet pattern” and “high alcohol and low rice pattern” in women. Serum LDL cholesterol in men was associated with “high bread and low rice pattern” score (Q5 was 4.2 mg/dL higher than Q1, p for trend ＜0.001) and “high confectioneries and low alcohol pattern” scores (Q5 was 9.5 mg/ dL higher than Q1, p for trend ＜0.001). In women, serum LDL cholesterol was associated with “high bread and low rice pattern” score (Q5 was 7.1 mg/dL higher than Q1, p for trend ＜0.001). Conclusion: Some recent dietary patterns in Japan were associated with serum LDL cholesterol. Serum LDL cholesterol was associated with high bread and low rice pattern in both sex, and high confectioneries and low alcohol pattern in men.

DOI： 10.5551/jat.63675

Irregular sleep and all-cause mortality: A large prospective cohort study 査読有り国際誌

Omichi, C; Koyama, T; Kadotani, H; Ozaki, E; Tomida, S; Yoshida, T; Otonari, J; Ikezaki, H; Hara, M; Tanaka, K; Tamura, T; Nagayoshi, M; Okada, R; Kubo, Y; Oze, I; Matsuo, K; Nakamura, Y; Kusakabe, M; Ibusuki, R; Shibuya, K; Suzuki, S; Watanabe, M; Kuriki, K; Takashima, N; Kadota, A; Katsuura-Kamano, S; Arisawa, K; Takeuchi, K; Wakai, K

SLEEP HEALTH 8 巻 ( 6 ) 頁： 678 - 683 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Sleep Health

Objectives: Previous studies using objective parameters have shown that irregular sleep is associated with the disease incidence, progression, or mortality. This study aimed to determine the association between subjective sleep duration and sleep regularity, with mortality in a large population. Methods: Participants were from the Japan Multi-Institutional Collaborative Cohort study. We obtained information from each participant on sleep duration, sleep regularity, and demographics and overall lifestyle using self-administered questionnaires. We defined sleep regularity according to participants' subjective assessment of sleep/wake time regularity. Participants (n = 81,382, mean age: 58.1 ± 9.1years, males: 44.2%) were classified into 6 groups according to sleep duration and sleep regularity. Hazard ratios (HR) for time-to-event of death were calculated using the Cox proportional hazards model. Results: The mean follow-up period was 9.1 years and the mean sleep duration was 6.6 h/day. Irregular sleep significantly increased the risk of all-cause mortality in all models compared with regular sleep (HR 1.30, 95% confidence interval; CI, 1.18-1.44), regardless of sleep duration. Multivariable analysis of the 6 groups by sleep pattern (sleep regularity and duration) showed irregular sleep and sleep durations of <6 h/day, 6 to <8 h/day, or ≥8 h/day were associated with a 1.2-1.5-fold increases in mortality, compared to regular sleep and sleep duration of 6 to <8 h/day. Conclusions: Our study shows an association between sleep irregularity and all-cause mortality in a large Japanese population. Our findings provide further confirmation of the need to consider not only sleep duration, but also the regularity aspect of sleep schedules.

DOI： 10.1016/j.sleh.2022.08.010

Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study. 査読有り国際誌

Saita K, Sumitani M, Nishizawa D, Tamura T, Ikeda K, Wakai K, Sudo Y, Abe H, Otonari J, Ikezaki H, Takeuchi K, Hishida A, Tanaka K, Shimanoe C, Takezaki T, Ibusuki R, Oze I, Ito H, Ozaki E, Matsui D, Nakamura Y, Kusakabe M, Suzuki S, Nakagawa-Senda H, Arisawa K, Katsuura-Kamano S, Kuriki K, Kita Y, Nakamura Y, Momozawa Y, Uchida K

Medicine 101 巻 ( 37 ) 頁： e30580 2022年9月

Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population 査読有り国際誌

Fujii, R; Hishida, A; Nakatochi, M; Tsuboi, Y; Suzuki, K; Kondo, T; Ikezaki, H; Hara, M; Okada, R; Tamura, T; Shimoshikiryo, I; Suzuki, S; Koyama, T; Kuriki, K; Takashima, N; Arisawa, K; Momozawa, Y; Kubo, M; Takeuchi, K; Wakai, K

CIRCULATION-GENOMIC AND PRECISION MEDICINE 15 巻 ( 4 ) 頁： 334 - 341 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Circulation: Genomic and Precision Medicine

Background: Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and to evaluate its ability in non-European populations. We developed a genome-wide PRS for blood pressure in a Japanese population and examined the associations between this PRS and hypertension prevalence. Methods: We performed a cross-sectional study in 11 252 Japanese individuals who participated in the J-MICC (Japan Multi-Institutional Collaborative Cohort) study. Using publicly available GWAS summary statistics from Biobank Japan, we developed the PRS in the target data (n=7876). With >30 000 single nucleotide polymorphisms, we evaluated PRS performance in the test data (n=3376). Hypertension was defined as systolic blood pressure of 130 mm Hg or more, or diastolic blood pressure of 85 mm Hg or more, or taking an antihypertensive drug. Results: Compared with the middle PRS quintile, the prevalence of hypertension at the top PRS quintile was higher independently from traditional risk factors (odds ratio, 1.73 [95% CI, 1.32-2.27]). The difference of mean systolic blood pressure and diastolic blood pressure between the middle and the top PRS quintile was 4.55 (95% CI, 2.26-6.85) and 2.32 (95% CI, 0.86-3.78) mm Hg, respectively. Subgroups reflecting combinations of Japanese PRS and modifiable lifestyles and factors (smoking, alcohol intake, sedentary time, and obesity) were associated with the prevalence of hypertension. A European-derived PRS was not associated with hypertension in our participants. Conclusions: A PRS for blood pressure was significantly associated with hypertension and BP traits in a general Japanese population. Our findings also highlighted the importance of a combination of PRS and risk factors for identifying high-risk subgroups.

DOI： 10.1161/CIRCGEN.121.003612

Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study 査読有り国際誌

Nguyen Tien Van, Arisawa Kokichi, Katsuura-Kamano Sakurako, Ishizu Masashi, Nagayoshi Mako, Okada Rieko, Hishida Asahi, Tamura Takashi, Hara Megumi, Tanaka Keitaro, Nishimoto Daisaku, Shibuya Keiichi, Koyama Teruhide, Watanabe Isao, Suzuki Sadao, Nishiyama Takeshi, Kuriki Kiyonori, Nakamura Yasuyuki, Saito Yoshino, Ikezaki Hiroaki, Otonari Jun, Koyanagi Yuriko N., Matsuo Keitaro, Mikami Haruo, Kusakabe Miho, Takeuchi Kenji, Wakai Kenji

PLOS ONE 17 巻 ( 7 ) 頁： e0269550 2022年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

Purpose The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population. Methods We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35–69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined. Results During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04–2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78–1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05). Conclusion MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.

DOI： 10.1371/journal.pone.0269550

OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts 査読有り国際誌

Toyoda Yu, Kawamura Yusuke, Nakayama Akiyoshi, Morimoto Keito, Shimizu Seiko, Tanahashi Yuki, Tamura Takashi, Kondo Takaaki, Kato Yasufumi, Ichida Kimiyoshi, Suzuki Hiroshi, Shinomiya Nariyoshi, Kobayashi Yasushi, Takada Tappei, Matsuo Hirotaka

FRONTIERS IN PHARMACOLOGY 13 巻頁： 842717 2022年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Frontiers in Pharmacology

Dysfunctional missense variant of organic anion transporter 10 (OAT10/SLC22A13), rs117371763 (c.1129C>T; p.R377C), is associated with a lower susceptibility to gout. OAT10 is a urate transporter; however, its physiological role in urate handling remains unclear. We hypothesized that OAT10 could be a renal urate re-absorber that will be a new molecular target of urate-lowering therapy like urate transporter 1 (URAT1, a physiologically-important well-known renal urate re-absorber) and aimed to examine the effect of OAT10 dysfunction on renal urate handling. For this purpose, we conducted quantitative trait locus analyses of serum urate and fractional excretion of uric acid (FEUA) using samples obtained from 4,521 Japanese males. Moreover, we performed immunohistochemical and functional analyses to assess the molecular properties of OAT10 as a renal urate transporter and evaluated its potential interaction with urate-lowering drugs. Clinico-genetic analyses revealed that carriers with the dysfunctional OAT10 variant exhibited significantly lower serum urate levels and higher FEUA values than the non-carriers, indicating that dysfunction of OAT10 increases renal urate excretion. Given the results of functional assays and immunohistochemical analysis demonstrating the expression of human OAT10 in the apical side of renal proximal tubular cells, our data indicate that OAT10 is involved in the renal urate reabsorption in renal proximal tubules from urine. Additionally, we found that renal OAT10 inhibition might be involved in the urate-lowering effect of losartan and lesinurad which exhibit uricosuric effects; indeed, losartan, an approved drug, inhibits OAT10 more strongly than URAT1. Accordingly, OAT10 can be a novel potential molecular target for urate-lowering therapy.

DOI： 10.3389/fphar.2022.842717

The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study 査読有り国際誌

Ohashi, M; Miura, K; Takashima, N; Kadota, A; Saito, Y; Tsuji, S; Murakami, T; Kadomatsu, Y; Nagayoshi, M; Hara, M; Tanaka, K; Tamura, T; Hishida, A; Takezaki, T; Shimoshikiryo, I; Ozaki, E; Watanabe, I; Suzuki, S; Watanabe, M; Kuriki, K; Arisawa, K; Katsuura-Kamano, S; Yamasaki, S; Ikezaki, H; Oze, I; Koyanagi, YN; Mikami, H; Nakamura, Y; Takeuchi, K; Kita, Y; Wakai, K

HYPERTENSION RESEARCH 45 巻 ( 4 ) 頁： 708 - 714 2022年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Hypertension Research

Previous studies have reported that the number of pregnancies and childbirths affected the risk of cardiovascular diseases (CVDs). However, the influence of reproductive history on hypertension and obesity, which are important risk factors for CVDs, is still unclear. Moreover, this association may vary depending on menopausal status. We evaluated the association of reproductive history with hypertension and obesity using a large cross-sectional dataset from the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). At the baseline survey, physical data, blood samples, and self-reported health questionnaires were collected. Participants with insufficient data were excluded, and 24,558 women from eight study regions were included in this study. Logistic regression analysis was conducted to evaluate the association of reproductive history with hypertension and obesity using multivariable-adjusted odds ratios. In premenopausal women, childbirth showed a generally protective effect on hypertension but not on obesity. In postmenopausal women, childbirth was positively associated with obesity and hypertension but not with hypertension after adjusting for BMI. In conclusion, reproductive history was associated with hypertension and obesity in a large Japanese population, and this association differed between premenopausal and postmenopausal women.

DOI： 10.1038/s41440-021-00820-0

Investigation of miRNA expression profiles using cohort samples reveals potential early detectability of colorectal cancers by serum miR-26a-5p before clinical diagnosis 査読有り国際誌

Hishida, A; Yamada, H; Ando, Y; Okugawa, Y; Shiozawa, M; Miyagi, Y; Daigo, Y; Toiyama, Y; Shirai, Y; Tanaka, K; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Mori, A; Kondo, T; Hamajima, N; Takeuchi, K; Wakai, K

ONCOLOGY LETTERS 23 巻 ( 3 ) 頁： 87 - 87 2022年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oncology Letters

Previous studies have investigated the usefulness of microRNA (miRNA/miR) expression data for the early detec- tion of colorectal cancer (CRC). However, limited data are available regarding miRNAs that detect CRC before clinical diagnoses. Accordingly, the present study investigated the early detectability of CRC by miRNAs using the preserved serum samples of the cohort participants affected with CRC within 2 years of study enrollment. First, the significant miRNAs were revealed using clinical CRC samples for a (seven early CRCs and seven controls) microarray analysis based on significance analysis of microarrays. Next, replica- bility was verified by reverse transcription-quantitative (RT-q) PCR (eight early CRCs and eight controls, together with 12 CRCs and 12 controls). Finally, early detectability was tested using the cohort samples of Japan Multi-Institutional Collaborative Cohort Study (17 CRCs and 17 controls) to reveal how a certain number of patients developed CRC within 2 years after participation. In the discovery phase, miRNA expression measurements were conducted using a 3D-Gene Human miRNA Oligo Chip for 2,555 miRNAs, and RT-qPCR analyses were performed to validate the replicability. In the first validation set with eight CRCs with early clinical stage and eight age- and gender-matched controls, miR-26a-5p and miR-223-3p demonstrated the highest diagnostic accu- racy of area under the curve (AUC)=1.000 (sensitivity and specificity 100%). In an examination of the predictability of CRC incidence using pre-clinical cohort samples, miR-26a-5p demonstrated good predictability of advanced CRC incidence with an AUC of 0.840. Overall, the present study revealed serum miR-26a-5p as a potential early detection marker for CRC.

DOI： 10.3892/ol.2022.13207

A genome-wide association study on adherence to low-carbohydrate diets in Japanese 査読有り国際誌

Nakamura Yasuyuki, Tamura Takashi, Narita Akira, Shimizu Atsushi, Sutoh Yoichi, Takashima Naoyuki, Matsui Kenji, Miyagawa Naoko, Kadota Aya, Miura Katsuyuki, Otonari Jun, Ikezaki Hiroaki, Hishida Asahi, Nagayoshi Mako, Okada Rieko, Kubo Yoko, Tanaka Keitaro, Shimanoe Chisato, Ibusuki Rie, Nishimoto Daisaku, Oze Isao, Ito Hidemi, Ozaki Etsuko, Matsui Daisuke, Mikami Haruo, Kusakabe Miho, Suzuki Sadao, Watanabe Miki, Arisawa Kokichi, Katsuura-Kamano Sakurako, Kuriki Kiyonori, Nakatochi Masahiro, Momozawa Yukihide, Kubo Michiaki, Takeuchi Kenji, Wakai Kenji

EUROPEAN JOURNAL OF CLINICAL NUTRITION 2022年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Journal of Clinical Nutrition

Background/objectives: Low-carbohydrate diets (LCD) are useful for weight reduction, and 50–55% carbohydrate consumption is associated with minimal risk. Genetic differences were related to nutritional consumption, food preferences, and dietary patterns, but whether particular genetic differences in individuals influence LCD adherence is unknown. Subjects/methods: We conducted a GWAS on adherence to LCD utilizing 14,076 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a previously validated semiquantitative food frequency questionnaire to estimate food consumption. Association of the imputed variants with the LCD score by Halton et al. we used linear regression analysis adjusting for sex, age, total dietary energy consumption, and components 1 to 10 by principal component analysis. We repeated the analysis with adjustment for alcohol consumption (g/day) in addition to the above-described variables. Results: Men and women combined analysis without adjustment for alcohol consumption; we found 395 variants on chromosome 12 associated with the LCD score having P values <5 × 10−8. A conditional analysis with the addition of the dosage data of rs671 on chromosome 12 as a covariate, P values for all 395 SNPs on chromosome 12 turned out to be insignificant. In the analysis with additional adjustment for alcohol consumption, we did not identify any SNPs associated with the LCD score. Conclusion: We found rs671 was inversely associated with adherence to LCD, but that was strongly confounded by alcohol consumption.

DOI： 10.1038/s41430-022-01090-w

Associations of breastfeeding history with metabolic syndrome and cardiovascular risk factors in community-dwelling parous women: The Japan Multi-Institutional Collaborative Cohort Study 査読有り国際誌

Matsunaga, T; Kadomatsu, Y; Tsukamoto, M; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Hishida, A; Takezaki, T; Shimoshikiryo, I; Suzuki, S; Nakagawa, H; Takashima, N; Saito, Y; Kuriki, K; Arisawa, K; Katsuura-Kamano, S; Kuriyama, N; Matsui, D; Mikami, H; Nakamura, Y; Oze, I; Ito, H; Murata, M; Ikezaki, H; Nishida, Y; Shimanoe, C; Takeuchi, K; Wakai, K

PLOS ONE 17 巻 ( 1 ) 頁： e0262252 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

Objective The aim of the present study was to investigate the associations between breastfeeding and the prevalence of metabolic syndrome in community-dwelling parous women and to clarify whether the associations depend on age. Methods The present cross-sectional study included 11,118 women, aged 35–69 years. Participants’ longest breastfeeding duration for one child and their number of breastfed children were assessed using a self-administered questionnaire, and their total breastfeeding duration was approximated as a product of the number of breastfed children and the longest breastfeeding duration. The longest and the total breastfeeding durations were categorized into none and tertiles above 0 months. Metabolic syndrome and cardiovascular risk factors (obesity, hypertension, dyslipidemia, and hyperglycemia) were defined as primary and secondary outcomes, respectively. Associations between breastfeeding history and metabolic syndrome or each cardiovascular risk factor were assessed using multivariable unconditional logistic regression analysis. Results Among a total of 11,118 women, 10,432 (93.8%) had ever breastfed, and 1,236 (11.1%) had metabolic syndrome. In participants aged <55 years, an inverse dose–response relationship was found between the number of breastfed children and the prevalence of metabolic syndrome; multivariable-adjusted odds ratios for 1, 2, 3, and ?4 breastfed children were 0.60 (95% confidence interval [CI]: 0.31 to 1.17), 0.50 (95% CI: 0.29 to 0.87), 0.44 (95% CI: 0.24 to 0.84), and 0.35 (95% CI: 0.14 to 0.89), respectively. The longest and total breastfeeding durations of longer than 0 months were also associated with lower odds of metabolic syndrome relative to no breastfeeding history in participants aged <55 years. In contrast, all measures of breastfeeding history were not significantly associated with metabolic syndrome and cardiovascular risk factors in participants aged ?55 years old. Conclusions Breastfeeding history may be related to lower prevalence of metabolic syndrome in middleaged parous women.

DOI： 10.1371/journal.pone.0262252

Association of perceived stress and coping strategies with the renal function in middle-aged and older Japanese men and women 査読有り国際誌

Koga, K; Hara, M; Shimanoe, C; Nishida, Y; Furukawa, T; Iwasaka, C; Tanaka, K; Otonari, J; Ikezaki, H; Kubo, Y; Kato, Y; Tamura, T; Hishida, A; Matsuo, K; Ito, H; Nakamura, Y; Kusakabe, M; Nishimoto, D; Shibuya, K; Suzuki, S; Watanabe, M; Ozaki, E; Matsui, D; Kuriki, K; Takashima, N; Kadota, A; Arisawa, K; Katsuura-Kamano, S; Takeuchi, K; Wakai, K

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 291 - 291 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Elucidating the risk factors for chronic kidney disease is important for preventing end-stage renal disease and reducing mortality. However, little is known about the roles of psychosocial stress and stress coping behaviors in deterioration of the renal function, as measured by the estimated glomerular filtration rate (eGFR). This cross-sectional study of middle-aged and older Japanese men (n = 31,703) and women (n = 38,939) investigated whether perceived stress and coping strategies (emotional expression, emotional support seeking, positive reappraisal, problem solving, and disengagement) were related to the eGFR, with mutual interactions. In multiple linear regression analyses adjusted for age, area, lifestyle factors, and psychosocial variables, we found a significant inverse association between perceived stress and the eGFR in men (Ptrend = 0.02), but not women. This male-specific inverse association was slightly attenuated after adjustment for the history of hypertension and diabetes and was more evident in lower levels of emotional expression (Pinteraction = 0.003). Unexpectedly, problem solving in men (Ptrend < 0.001) and positive reappraisal in women (Ptrend = 0.002) also showed an inverse association with the eGFR. Perceived stress may affect the eGFR, partly through the development of hypertension and diabetes. The unexpected findings regarding coping strategies require the clarification of the underlying mechanisms, including the hormonal and immunological aspects.

DOI： 10.1038/s41598-021-04324-2

Alcohol intake and stomach cancer risk in Japan: A pooled analysis of six cohort studies 査読有り国際誌

Tamura, T; Wakai, K; Lin, YS; Tamakoshi, A; Utada, M; Ozasa, K; Sugawara, Y; Tsuji, I; Ono, A; Sawada, N; Tsugane, S; Ito, H; Nagata, C; Kitamura, T; Naito, M; Tanaka, K; Shimazu, T; Mizoue, T; Matsuo, K; Inoue, M

CANCER SCIENCE 113 巻 ( 1 ) 頁： 261 - 276 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancer Science

The association between alcohol intake and stomach cancer risk remains controversial. We undertook a pooled analysis of data from six large-scale Japanese cohort studies with 256 478 participants on this topic. Alcohol intake as ethanol was estimated using a validated questionnaire. The participants were followed for incidence of stomach cancer. We calculated study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for stomach cancer according to alcohol intake using a Cox regression model. Summary HRs were estimated by pooling the study-specific HRs using a random-effects model. During 4 265 551 person-years of follow-up, 8586 stomach cancer cases were identified. In men, the multivariate-adjusted HRs (95% CIs) of stomach cancer were 1.00 (0.87-1.15) for occasional drinkers, and 1.00 (0.91-1.11) for <23 g/d, 1.09 (1.01-1.18) for 23 to <46 g/d, 1.18 (1.09-1.29) for 46 to <69 g/d, 1.21 (1.05-1.39) for 69 to <92 g/d, and 1.29 (1.11-1.51) for ≥92 g/d ethanol in regular drinkers compared with nondrinkers. In women, the multivariate-adjusted HRs were 0.93 (0.80-1.08) for occasional drinkers, and 0.85 (0.74-0.99) for <23 g/d, and 1.22 (0.98-1.53) for ≥23 g/d in regular drinkers compared with nondrinkers. The HRs for proximal and distal cancer in drinkers vs nondrinkers were 1.69 (1.15-2.47) and 1.24 (0.99-1.55) for ≥92 g/d in men, and 1.60 (0.76-3.37) and 1.18 (0.88-1.57) for ≥23 g/d in women, respectively. Alcohol intake increased stomach cancer risk in men, and heavy drinkers showed a greater point estimate of risk for proximal cancer than for distal cancer.

DOI： 10.1111/cas.15172

Effect of the interaction between physical activity and estimated macronutrient intake on HbA1c: population-based cross-sectional and longitudinal studies 査読有り国際誌

Furukawa, T; Nishida, Y; Hara, M; Shimanoe, C; Koga, K; Iwasaka, C; Higaki, Y; Tanaka, K; Nakashima, R; Ikezaki, H; Hishida, A; Tamura, T; Kato, Y; Tamada, Y; Matsuo, K; Ito, H; Mikami, H; Kusakabe, M; Ibusuki, R; Shibuya, K; Suzuki, S; Nakagawa-Senda, H; Ozaki, E; Matsui, D; Kuriki, K; Nakamura, Y; Kadota, A; Arisawa, K; Katsuura-Kamano, S; Takeuchi, K; Wakai, K

BMJ OPEN DIABETES RESEARCH & CARE 10 巻 ( 1 ) 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BMJ Open Diabetes Research and Care

Introduction Healthy diet and physical activity (PA) are essential for preventing type 2 diabetes, particularly, a combination of diet and PA. However, reports on interaction between PA and diet, especially from large epidemiological studies, are limited. We investigated the effect of interaction between PA and macronutrient intake on hemoglobin A1c (HbA1c) levels in the general population. Research design and methods We conducted a cross-sectional study of 55 469 men and women without diabetes who participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. A self-administered questionnaire ascertained PA and macronutrient intake (carbohydrate, fat, and protein). Multiple linear regression analyses were performed to adjust for confounding variables and examine the interactions. In addition, we conducted a longitudinal study during a 5-year period within a subcohort (n=6881) with accelerometer-assessed PA data. Results Overall, PA had a weak inverse association (β=-0.00033, p=0.049) and carbohydrate intake had a strong positive association (β=0.00393, p<0.001) with HbA1c. We observed a tendency of interactions between PA and carbohydrate or fat intake, but not protein intake, on HbA1c levels after adjusting for age, sex, study area, total energy intake, alcohol consumption, smoking, and medication for hypertension or hypercholesterolemia (P interaction =0.054, 0.006, and 0.156, respectively). The inverse associations between PA and HbA1c level were more evident in participants with high-carbohydrate (or low-fat) intake than in participants with low-carbohydrate (or high-fat) intake. Although further adjustment for body mass index slightly attenuated the above interactions (P interaction =0.098 for carbohydrate and 0.068 for fat), the associations between PA and HbA1c level in stratified analyses remained unchanged. Similar associations and interactions were reproduced in the longitudinal study. Conclusions The present results suggest that the effect of PA on HbA1c levels is modified by intake of macronutrient composition.

DOI： 10.1136/bmjdrc-2021-002479

Association of skipping breakfast and short sleep duration with the prevalence of metabolic syndrome in the general Japanese population: Baseline data from the Japan Multi-Institutional Collaborative cohort study 査読有り国際誌

Katsuura-Kamano, S; Arisawa, K; Uemura, H; Nguyen, TV; Takezaki, T; Ibusuki, R; Suzuki, S; Otani, T; Okada, R; Kubo, Y; Tamura, T; Hishida, A; Koyama, T; Matsui, D; Kuriki, K; Takashima, N; Miyagawa, N; Ikezaki, H; Matsumoto, Y; Nishida, Y; Shimanoe, C; Oze, I; Matsuo, K; Mikami, H; Kusakabe, M; Takeuchi, K; Wakai, K

PREVENTIVE MEDICINE REPORTS 24 巻頁： 101613 - 101613 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Preventive Medicine Reports

The purpose of the study was to investigate sex-specific associations of skipping breakfast and short sleep duration with metabolic syndrome (MetS) and their interaction. We analyzed baseline data of 14,907 men and 14,873 women aged 35–69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study from 2005. MetS was diagnosed using a modification of the National Cholesterol Education Program Adult Treatment Panel III revised definition (NCEP-R 2005), using body mass index instead of waist circumference. Breakfast consumption was classified into two categories: ≥6 days/week (consumers) or <6 days/week (skippers). Sleep duration was classified into three categories: <6h, 6 to <8 h, and ≥8 h/day. Multivariate logistic regression analysis was performed to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) and examine the presence of interaction. In men, skipping breakfast and short sleep duration were independently associated with an increased prevalence of MetS (OR 1.26, 95%CI 1.12–1.42 and OR 1.28, 95%CI 1.12–1.45, respectively), obesity, and components of MetS. However, no significant interaction was observed between skipping breakfast and short sleep duration. In women, skipping breakfast and short sleep duration were associated with an increased prevalence of obesity, but not with MetS. These findings indicate that breakfast consumption and moderate sleep duration may be associated with a lower risk of MetS, particularly in men.

DOI： 10.1016/j.pmedr.2021.101613

Moderate-to-vigorous physical activity and sedentary behavior are independently associated with renal function: a cross-sectional study. 査読有り

Hara M, Nishida Y, Tanaka K, Shimanoe C, Koga K, Furukawa T, Higaki Y, Shinchi K, Ikezaki H, Murata M, Takeuchi K, Tamura T, Hishida A, Tsukamoto M, Kadomatsu Y, Matsuo K, Oze I, Haruo M, Miho K, Takezaki T, Ibusuki R, Suzuki S, Nakagawa-Senda H, Matsui D, Koyama T, Kuriki K, Takashima N, Nakamura Y, Arisawa K, Katsuura-Kamano S, Wakai K

Journal of epidemiology advpub 巻 ( 0 ) 2021年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：日本疫学会

<p><b>Background:</b> Little is known about whether insufficient moderate-to-vigorous physical activity (MVPA) and longer sedentary behavior (SB) are independently associated with estimated glomerular filtration rate (eGFR) and CKD, whether they interact with known risk factors for CKD, and the effect of replacing sedentary time with an equivalent duration of physical activity on kidney function.</p><p><b>Methods:</b> We examined the cross-sectional association of MVPA and SB with eGFR and CKD in 66,603 Japanese cohort study in 14 areas from 2004 to 2013. MVPA and SB were estimated using a self-reported questionnaire, and CKD was defined as eGFR<60 mL/min/1.73 m<sup>2</sup>. Multiple linear regression analyses, logistic regression analyses, and an isotemporal substitution model were applied.</p><p><b>Results:</b> After adjusting for potential confounders, higher MVPA and longer SB were independently associated with higher eGFR (P<sub>for trend MVPA</sub><0.0001) and lower eGFR (P<sub>for trend SB</sub><0.0001), and a lower odds ratio (OR) of CKD (adjusted OR of MVPA≥20 MET·h/day: 0.76 [95%CI: 0.68–0.85] compared to MVPA<5 MET·h/day) and a higher OR of CKD (adjusted OR of SB≥16 h/day: 1.81 [95%CI: 1.52–2.15] compared to SB<7 h/day), respectively. The negative association between MVPA and CKD was stronger in men, and significant interactions between sex and MVPA were detected. Replacing 1 hour of SB with 1 hour of physical activity was associated with about 3 to 4% lower OR of CKD.</p><p><b>Conclusions:</b> These findings indicate that replacing SB with physical activity may benefit kidney function, especially in men, adding to the possible evidence on CKD prevention.</p>

DOI： 10.2188/jea.JE20210155

A genome-wide association study on meat consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort study 査読有り国際誌

Nakamura, Y; Narita, A; Sutoh, Y; Imaeda, N; Goto, C; Matsui, K; Takashima, N; Kadota, A; Miura, K; Nakatochi, M; Tamura, T; Hishida, A; Nakashima, R; Ikezaki, H; Hara, M; Nishida, Y; Takezaki, T; Ibusuki, R; Oze, I; Ito, H; Kuriyama, N; Ozaki, E; Mikami, H; Kusakabe, M; Nakagawa-Senda, H; Suzuki, S; Katsuura-Kamano, S; Arisawa, K; Kuriki, K; Momozawa, Y; Kubo, M; Takeuchi, K; Kita, Y; Wakai, K

JOURNAL OF NUTRITIONAL SCIENCE 10 巻頁： e61 2021年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Nutritional Science

Recent genome-wide association studies (GWAS) on the dietary habits of the Japanese population have shown that an effect rs671 allele was inversely associated with fish consumption, whereas it was directly associated with coffee consumption. Although meat is a major source of protein and fat in the diet, whether genetic factors that influence meat-eating habits in healthy populations are unknown. This study aimed to conduct a GWAS to find genetic variations that affect meat consumption in a Japanese population. We analysed GWAS data using 14 076 participants from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. We used a semi-quantitative food frequency questionnaire to estimate food intake that was validated previously. Association of the imputed variants with total meat consumption per 1000 kcal energy was performed by linear regression analysis with adjustments for age, sex, and principal component analysis components 1-10. We found that no genetic variant, including rs671, was associated with meat consumption. The previously reported single nucleotide polymorphisms that were associated with meat consumption in samples of European ancestry could not be replicated in our J-MICC data. In conclusion, significant genetic factors that affect meat consumption were not observed in a Japanese population.

DOI： 10.1017/jns.2021.49

Sex-specific Relationship between Stress Coping Strategies and All-Cause Mortality: Japan Multi-Institutional Collaborative Cohort Study. 査読有り

Nagayoshi M, Takeuchi K, Tamada Y, Yasufumi K, Kubo Y, Okada R, Tamura T, Hishida A, Otonari J, Ikezaki H, Nishida Y, Shimanoe C, Koyanagi YN, Matsuo K, Haruo M, Miho K, Nishimoto D, Shibuya K, Suzuki S, Nishiyama T, Ozaki E, Watanabe I, Kuriki K, Takashima N, Kadota A, Arisawa K, Katsuura-Kamano S, Wakai K

Journal of epidemiology 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：日本疫学会

<p><b>Background:</b> Stress coping strategies are related to health outcomes. However, there is no clear evidence for sex differences between stress-coping strategies and mortality. We investigated the relationship between all-cause mortality and stress-coping strategies, focusing on sex differences among Japanese adults.</p><p><b>Methods</b>: A total of 79,580 individuals aged 35–69 years participated in the Japan Multi-Institutional Collaborative Cohort Study between 2004 and 2014 and were followed up for mortality. The frequency of use of the five coping strategies was assessed using a questionnaire. Sex-specific, multivariable-adjusted hazard ratios (HRs) for using each coping strategy "sometimes," and "often/very often" (versus "very few" use) were computed for all-cause mortality. Furthermore, relationships were analyzed in specific follow-up periods when the proportion assumption was violated.</p><p><b>Results</b>: During the follow-up (median: 8.5 years), 1,861 mortalities were recorded. In women, three coping strategies were related to lower total mortality. The HRs (95% confidence intervals) for "sometimes" were 0.81 (0.67–0.97) for emotional expression, 0.79 (0.66–0.95) for emotional support-seeking, and 0.80 (0.66–0.98) for disengagement. Men who "sometimes" used emotional expression and sometimes or often used problem-solving and positive reappraisal had a 15–41% lower HRs for all-cause mortality. However, those relationships were dependent on the follow-up period. There was evidence that sex modified the relationships between emotional support-seeking and all-cause mortality (<i>p</i> for interaction = 0.03).</p><p><b>Conclusions</b>: In a large Japanese population, selected coping strategies were associated with all-cause mortality. The relationship of emotional support-seeking was different between men and women.</p>

DOI： 10.2188/jea.JE20210220

Population-Based Impact of Smoking, Drinking, and Genetic Factors on HDL-Cholesterol Levels in J-MICC Study Participants. 査読有り

Nindita Y, Nakatochi M, Ibusuki R, Shimoshikiryo I, Nishimoto D, Shimatani K, Takezaki T, Ikezaki H, Murata M, Hara M, Nishida Y, Tamura T, Hishida A, Nagayoshi M, Okada R, Matsuo K, Ito H, Mikami H, Nakamura Y, Otani T, Suzuki S, Koyama T, Ozaki E, Kuriki K, Takashima N, Miyagawa N, Arisawa K, Katsuura-Kamao S, Momozawa Y, Kubo M, Takeuchi K, Wakai K

Journal of epidemiology 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：日本疫学会

<p><b>Background</b>: Environmental and genetic factors are suggested to exhibit factor-based association with HDL-cholesterol (HDL-C) levels. However, the population-based effects of environmental and genetic factors have not been compared clearly. We conducted a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study to evaluate the population-based impact of smoking, drinking, and genetic factors on low HDL-C.</p><p><b>Methods:</b> Data from 11,498 men and women aged 35-69 years were collected for a genome-wide association study (GWAS). Sixty-five HDL-C-related SNPs with genome-wide significance (<i>P</i> < 5 × 10<sup>-8</sup>) were selected from the GWAS catalog, and seven representative SNPs were defined, and the population-based impact was estimated using population attributable fraction (PAF).</p><p><b>Results</b>: We found that smoking, drinking, daily activity, habitual exercise, egg intake, BMI, age, sex and the SNPs <i>CETP</i> rs3764261, <i>APOA5</i> rs662799, <i>LIPC</i> rs1800588, <i>LPL</i> rs328, <i>ABCA1</i> rs2575876, <i>LIPG</i> rs3786247, and <i>APOE</i> rs429358 were associated with HDL-C levels. The gene-environmental interactions on smoking and drinking were not statistically significant. The PAF for low HDL-C was the highest in men (63.2%) and in rs3764261 (31.5%) of the genetic factors, and the PAFs of smoking and drinking were 23.1% and 41.8%, respectively.</p><p><b>Conclusions:</b> The present study showed that the population-based impact of genomic factor <i>CETP</i> rs3764261 for low HDL-C was higher than that of smoking and lower than that of drinking.</p>

DOI： 10.2188/jea.JE20210142

A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of URAT1/SLC22A12 among 30,685 Japanese Individuals 査読有り国際誌

Kawamura Yusuke, Nakayama Akiyoshi, Shimizu Seiko, Toyoda Yu, Nishida Yuichiro, Hishida Asahi, Katsuura-Kamano Sakurako, Shibuya Kenichi, Tamura Takashi, Kawaguchi Makoto, Suzuki Satoko, Iwasawa Satoko, Nakashima Hiroshi, Ibusuki Rie, Uemura Hirokazu, Hara Megumi, Takeuchi Kenji, Takada Tappei, Tsunoda Masashi, Arisawa Kokichi, Takezaki Toshiro, Tanaka Keitaro, Ichida Kimiyoshi, Wakai Kenji, Shinomiya Nariyoshi, Matsuo Hirotaka

BIOMEDICINES 9 巻 ( 8 ) 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Biomedicines

Background: Renal hypouricemia (RHUC) is characterized by a low serum uric acid (SUA) level and high fractional excretion of uric acid (FEUA). Further studies on FEUA in hypouricemic individuals are needed for a more accurate diagnosis of RHUC. Methods: In 30,685 Japanese health-examination participants, we genotyped the two most common nonfunctional variants of URAT1 (NFV-URAT1), W258X (rs121907892) and R90H (rs121907896), in 1040 hypouricemic individuals (SUA ≤ 3.0 mg/dL) and 2240 individuals with FEUA data. The effects of NFV-URAT1 on FEUA and SUA were also investigated using linear and multiple regression analyses. Results: Frequency of hypouricemic individuals (SUA ≤ 3.0 mg/dL) was 0.97% (male) and 6.94% (female) among 30,685 participants. High frequencies of those having at least one allele of NFV-URAT1 were ob-served in 1040 hypouricemic individuals. Furthermore, NFV-URAT1 significantly increased FEUA and decreased SUA, enabling FEUA and SUA levels to be estimated. Conversely, FEUA and SUA data of hypouricemic individuals are revealed to be useful to predict the number of NFV-URAT1. Conclusions: Our findings reveal that specific patterns of FEUA and SUA data assist with predicting the number of nonfunctional variants of causative genes for RHUC, and can also be useful for practical diagnosis of RHUC even before genetic tests.

DOI： 10.3390/biomedicines9081012

A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern 査読有り国際誌

Suzuki Harumitsu, Nakamura Yasuyuki, Matsuo Keitaro, Imaeda Nahomi, Goto Chiho, Narita Akira, Shimizu Atsushi, Takashima Naoyuki, Matsui Kenji, Miura Katsuyuki, Nakatochi Masahiro, Hishida Asahi, Tamura Takashi, Kadomatsu Yuka, Okada Rieko, Nishida Yuichiro, Shimanoe Chisato, Nishimoto Daisaku, Takezaki Toshiro, Oze Isao, Ito Hidemi, Ikezaki Hiroaki, Murata Masayuki, Matsui Daisuke, Ozaki Etsuko, Mikami Haruo, Nakamura Yohko, Suzuki Sadao, Watanabe Miki, Arisawa Kokichi, Uemura Hirokazu, Kuriki Kiyonori, Momozawa Yukihide, Kubo Michiaki, Kita Yoshikuni, Takeuchi Kenji, Wakai Kenji

EUROPEAN JOURNAL OF CLINICAL NUTRITION 75 巻 ( 6 ) 頁： 937 - 945 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Journal of Clinical Nutrition

Background/Objectives: Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. Subjects/Methods: We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region. Results: We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values <5 × 10−8. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. Conclusion: We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.

DOI： 10.1038/s41430-020-00823-z

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