研究者詳細 - 田村　高志

GWAS of folate metabolism with gene-environment interaction analysis revealed the possible role of lifestyles in the control of blood folate metabolites in Japanese-the J-MICC Study. 査読有り

Association between dysphagia risk and sleep quality in community-dwelling older adults: A cross-sectional study 査読有り国際誌 Open Access

Hama, Y; Yamada, S; Nishimura, R; Yoshida, M; Tsuga, K; Morita, E; Tamada, Y; Kato, Y; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Hishida, A; Wakai, K; Naito, M

HELIYON 10 巻 ( 11 ) 頁： e32028 2024年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Heliyon

Objectives: Exploring the effects of swallowing function on sleep quality could provide valuable insights into the potential impact of reduced swallowing function on sleep. However, pertinent studies are limited. Therefore, this study aimed to investigate the relationship between dysphagia risk and sleep health in community-dwelling older adults. Methods: Data for this cross-sectional study were obtained from the Shizuoka and Daiko studies conducted as part of the Japan Multi-Institutional Collaborative Cohort Study. Information on demographics, overall lifestyle, dysphagia risk, as well as sleep quality, duration, satisfaction, and regularity, was obtained using a self-administered questionnaire. Dysphagia risk and sleep quality were assessed using the Dysphagia Risk Assessment Questionnaire for the Community-dwelling Elderly and the Japanese version of the Pittsburgh Sleep Questionnaire Index, respectively. Multivariate logistic regression, adjusted for covariates, was employed to assess the association between dysphagia risk and sleep health. Results: Among the 3058 participants (1633 males, 1425 females) aged ≥60 years, 28.0 % exhibited dysphagia risk, and 19.1 % reported poor sleep quality. Those with dysphagia risk were more likely to experience poor sleep quality than those without dysphagia risk. In male participants, dysphagia was significantly associated with poor sleep quality, unsatisfactory sleep, and sleep irregularity, but was not significantly associated with unsatisfactory or irregular sleep in female participants. The Japanese version of the Pittsburgh Sleep Questionnaire Index components—subjective sleep quality, sleep latency, sleep disturbances, and daytime dysfunction—were associated with dysphagia risk in both sexes. Conclusions: Dysphagia risk is associated with sleep quality in older individuals in Japan. Thus, preserving swallowing function may contribute to enhancing sleep quality.

DOI： 10.1016/j.heliyon.2024.e32028

Association between awareness of limiting food intake and all-cause mortality: A cohort study in Japan. 査読有り

Nishimoto D, Ibusuki R, Shimoshikiryo I, Shibuya K, Tanoue S, Koriyama C, Takezaki T, Oze I, Ito H, Hishida A, Tamura T, Kato Y, Tamada Y, Nishida Y, Shimanoe C, Suzuki S, Nishiyama T, Ozaki E, Tomida S, Kuriki K, Miyagawa N, Kondo K, Arisawa K, Watanabe T, Ikezaki H, Otonari J, Wakai K, Matsuo K

Journal of epidemiology 34 巻 ( 0 ) 頁： 286 - 294 2024年6月

Elevated level of urinary tellurium is a potential risk for increase of blood pressure in humans and mice 査読有り国際誌 Open Access

Misawa, T; Kagawa, T; Ohgami, N; Tazaki, A; Ohnuma, S; Naito, H; Chen, DJ; Gu, YS; Tamura, T; Wakai, K; Nishiwaki, K; Kato, M

ENVIRONMENT INTERNATIONAL 188 巻頁： 108735 - 108735 2024年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environment International

Background: People worldwide are routinely exposed to tellurium mainly via dietary ingestion. There has been no study to clarify the contribution of tellurium to blood pressure in humans or animals. Methods: In this cross-sectional study conducted in a general population of 2592 residents in Japan, the associations of urinary tellurium levels with blood pressure and prevalence of hypertension were investigated. The potential sources of tellurium were also investigated. An interventional study in mice confirmed the effect of tellurium exposure on blood pressure. Results: Linear and logistic regression analyses with consideration of confounders including urinary sodium–potassium ratio showed significant positive associations of urinary tellurium level with prevalence of hypertension and blood pressure. Cereals/beans and vegetables/fruits were determined to be potential dietary sources of tellurium exposure. Intermediary analysis suggested that increased intake of cereals/beans, but not that of vegetables/fruits, is positively associated with the tellurium-mediated risk of hypertension. Correspondingly, the mouse study showed that exposure to a putative human-equivalent dose of tellurium via drinking water increased blood pressure with an elevated level of urinary tellurium. The temporally increased blood pressure was decreased to the normal level by a break of tellurium exposure with a reduced level of urinary tellurium. Conclusions: The interdisciplinary approach provided the first evidence that tellurium exposure is a potential risk for increase of blood pressure. Since the human urinary tellurium level in this study is comparable with the levels in general populations in other Asian and European countries in previous studies, exposure to tellurium may be a latent universal risk for hypertension.

DOI： 10.1016/j.envint.2024.108735

Tsukamoto, M; Hishida, A; Tamura, T; Nagayoshi, M; Okada, R; Kubo, Y; Kato, Y; Hamajima, N; Nishida, Y; Shimanoe, C; Ibusuki, R; Shibuya, K; Takashima, N; Nakamura, Y; Kusakabe, M; Nakamura, Y; Koyanagi, YN; Oze, I; Nishiyama, T; Suzuki, S; Watanabe, I; Matsui, D; Otonari, J; Ikezaki, H; Katsuura-Kamano, S; Arisawa, K; Kuriki, K; Nakatochi, M; Momozawa, Y; Takeuchi, K; Wakai, K; Matsuo, K

JOURNAL OF EPIDEMIOLOGY 34 巻頁： 228 - 237 2024年5月

Association between consumption of small fish and all-cause mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study 査読有り国際誌 Open Access

Kasahara, C; Tamura, T; Wakai, K; Tamada, Y; Kato, Y; Kubo, Y; Okada, R; Nagayoshi, M; Hishida, A; Imaeda, N; Goto, C; Otonari, J; Ikezaki, H; Nishida, Y; Shimanoe, C; Oze, I; Koyanagi, YN; Nakamura, Y; Kusakabe, M; Nishimoto, D; Shimoshikiryo, I; Suzuki, S; Watanabe, M; Ozaki, E; Omichi, C; Kuriki, K; Takashima, N; Miyagawa, N; Arisawa, K; Katsuura-Kamano, S; Takeuchi, K; Matsuo, K

PUBLIC HEALTH NUTRITION 27 巻 ( 1 ) 頁： e135 - 40 2024年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Public Health Nutrition

Objective: Although small fish are an important source of micronutrients, the relationship between their intake and mortality remains unclear. This study aimed to clarify the association between intake of small fish and all-cause and cause-specific mortality. Design: We used the data from a cohort study in Japan. The frequency of the intake of small fish was assessed using a validated FFQ. The hazard ratio (HR) and 95 % confidence interval (CI) for all-cause and cause-specific mortality according to the frequency of the intake of small fish by sex were estimated using a Cox proportional hazard model with adjustments for covariates. Setting: The Japan Multi-Institutional Collaborative Cohort Study. Participants: A total of 80 802 participants (34 555 males and 46 247 females), aged 35-69 years. Results: During a mean follow-up of 9·0 years, we identified 2482 deaths including 1495 cancer-related deaths. The intake of small fish was statistically significantly and inversely associated with the risk of all-cause and cancer mortality in females. The multivariable-adjusted HR (95 % CI) in females for all-cause mortality according to the intake were 0·68 (0·55, 0·85) for intakes 1-3 times/month, 0·72 (0·57, 0·90) for 1-2 times/week and 0·69 (0·54, 0·88) for ≥ 3 times/week, compared with the rare intake. The corresponding HR (95 % CI) in females for cancer mortality were 0·72 (0·54, 0·96), 0·71 (0·53, 0·96) and 0·64 (0·46, 0·89), respectively. No statistically significant association was observed in males. Conclusions: Intake of small fish may reduce the risk of all-cause and cancer mortality in Japanese females.

DOI： 10.1017/S1368980024000831

The Inverse Association between the Frequency of Forest Walking (Shinrin-yoku) and the Prevalence of Insomnia Symptoms in the General Japanese Population: A Japan Multi-Institutional Collaborative Cohort Daiko Study.

Morita E, Kadotani H, Yamada N, Sasakabe T, Kawai S, Naito M, Tamura T, Wakai K

International journal of environmental research and public health 21 巻 ( 3 ) 2024年3月

記述言語：英語出版者・発行元：International Journal of Environmental Research and Public Health

Since a single forest walk (Shinrin-yoku or forest bathing) session is reported to improve sleep temporarily, occasional forest walks may have a positive effect on daily sleep. Therefore, this study aimed to examine whether more frequent forest walking is associated with better daily sleep conditions. Data from the second survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Daiko Study conducted among residents of Nagoya City, Japan, were used. The study design was a cross-sectional study. In total, 2044 participants (529 men and 1515 women; age, mean ± standard deviation: 58.8 ± 9.9 years) were included in the analysis. Frequent forest walks were associated with a low percentage of insomnia symptoms (Insomnia Severity Index ≥10) in women, but not in men. The adjusted odds ratio for the group that rarely took forest walks with reference to the group that engaged in the activity once a month or more often was 2.04 (95% confidence interval: 1.29–3.23) in women. Forest walk frequency was not significantly associated with sleep duration or sleep efficiency as measured by actigraphy in either men or women. In conclusion, the results suggested that increasing the frequency of forest walks or Shinrin-yoku may be effective in preventing insomnia in women.

DOI： 10.3390/ijerph21030350

Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study 査読有り

BMI and cardiometabolic traits in Japanese: a Mendelian randomization study 査読有り

Nagayoshi, M; Hishida, A; Shimizu, T; Kato, Y; Kubo, Y; Okada, R; Tamura, T; Otonari, J; Ikezaki, H; Hara, M; Nishida, Y; Oze, I; Koyanagi, YN; Nakamura, Y; Kusakabe, M; Ibusuki, R; Shibuya, K; Suzuki, S; Nishiyama, T; Koyama, T; Ozaki, E; Kuriki, K; Takashima, N; Nakamura, Y; Katsuura-Kamanos, S; Arisawa, K; Nakatochi, M; Momozawa, Y; Takeuchi, K; Wakai, K; J-MICC Study Grp

JOURNAL OF EPIDEMIOLOGY 34 巻頁： 51 - 62 2024年2月

Tomida, S; Koyama, T; Ozaki, E; Takashima, N; Morita, M; Sakaguchi, K; Naoi, Y; Nishida, Y; Hara, M; Hishida, A; Tamura, T; Okada, R; Kubo, Y; Otonari, J; Ikezaki, H; Nakamura, Y; Kusakabe, M; Tanoue, S; Koriyama, C; Koyanagi, YN; Ito, H; Suzuki, S; Otani, T; Miyagawa, N; Okami, Y; Arisawa, K; Watanabe, T; Kuriki, K; Wakai, K; Matsuo, K

CANCER SCIENCE 115 巻頁： 611 - 622 2024年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancer Science

This study aimed to investigate the association between daily sedentary time and the risk of breast cancer (BC) in a large Japanese population. The participants were 36,023 women aged 35–69 years from the Japan Multi-Institutional Collaborative Cohort Study. Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for BC incidence in relation to time spent sedentarily (categorical variables: <7 and ≥7 hours/day [h/d]). Additionally, the associations of BC incidence to the joint effect of sedentary time with each component of physical activity, such as leisure-time metabolic equivalents (METs), frequency of leisure-time physical activity, and daily walking time, were examined. During 315,189 person-years of follow-up, 554 incident cases of BC were identified. When compared to participants who spent <7 h/d sedentary, those who spent ≥7 h/d sedentary have a significantly higher risk of BC (HR, 1.36; 95% CI, 1.07–1.71). The corresponding HRs among participants who spent ≥7 h/d sedentary with more physical activity, such as ≥1 h/d for leisure-time METs, ≥3 days/week of leisure-time physical activity, and ≥1 h/d of daily walking were 1.58 (95% CI, 1.11–2.25), 1.77 (95% CI, 1.20–2.61), and 1.42 (95% CI, 1.10–1.83), respectively, compared with those who spent <7 h/d sedentary. This study found that spending ≥7 h/d of sedentary time is associated with the risk of BC. Neither leisure-time physical activity nor walking had a BC-preventive effect in those with ≥7 h/d of sedentary time.

DOI： 10.1111/cas.16020

Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice. 査読有り国際誌 Open Access

Kagawa T, Ohgami N, He T, Tazaki A, Ohnuma S, Naito H, Yajima I, Chen D, Deng Y, Tamura T, Kondo T, Wakai K, Kato M

European heart journal open 3 巻 ( 5 ) 頁： oead074 2023年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Heart Journal Open

Aims: There has been a shortage of human studies to elucidate the association between serum arsenic levels and the prevalence of hypertension. This study multidirectionally investigated associations among arsenic exposure, dietary ingestion, and the risk of hypertension by combined human epidemiological and mouse experimental studies. Methods and results: This study focused on the total arsenic level in fasting serum, a biomarker of arsenic exposure. Associations among ingestion frequencies of 54 diet items of Japanese food separated into six categories, total arsenic level in fasting serum, and the prevalence of hypertension were investigated in 2709 general people in Japan. Logistic regression analysis demonstrated a dose-dependent association between serum arsenic level and hypertension and a positive association between the ingestion of fish meat and hypertension. Further analysis showed that the latter association was fully mediated by increased fasting serum arsenic levels in humans. Similarly, oral exposure to the putative human-equivalent dose of arsenic species mixture with the same ratios in a common fish meat in Japan increased systolic blood pressure and arsenic levels in fasting serum in mice. Conclusion: This interdisciplinary approach suggests that fish-meat ingestion is a potential risk factor for arsenic-mediated hypertension. Because the increased consumption of fish meat is a recent global trend, health risks of the increased ingestion of arsenic via fish meat should be further investigated.

DOI： 10.1093/ehjopen/oead074

Open Access

Dietary Carbohydrate and Fat Intakes and Risk of Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study 査読有り国際誌

Tamura, T; Wakai, K; Kato, Y; Tamada, Y; Kubo, Y; Okada, R; Nagayoshi, M; Hishida, A; Imaeda, N; Goto, C; Ikezaki, H; Otonari, J; Hara, M; Tanaka, K; Nakamura, Y; Kusakabe, M; Ibusuki, R; Koriyama, C; Oze, I; Ito, H; Suzuki, S; Nakagawa-Senda, H; Ozaki, E; Matsui, D; Kuriki, K; Kondo, K; Takashima, N; Watanabe, T; Katsuura-Kamano, S; Matsuo, K

JOURNAL OF NUTRITION 153 巻 ( 8 ) 頁： 2352 - 2368 2023年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Nutrition

Background: Previous cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality. Objectives: We examined long-term associations of carbohydrate and fat intakes with mortality. Methods: In this cohort study, 34,893 men and 46,440 women aged 35–69 y (mean body mass index of 23.7 and 22.2 kg/m2, respectively) were followed up from the baseline survey (2004–2014) to the end of 2017 or 2018. Intakes of carbohydrate, fat, and total energy were estimated using a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for all-cause and cause-specific mortality according to percentage of energy intakes of carbohydrate and fat. Results: During a mean 8.9-y follow-up, we identified 2783 deaths (1838 men and 945 women). Compared with men who consumed 50% to <55% of energy from carbohydrate, those who consumed <40% carbohydrate energy experienced a significantly higher risk of all-cause mortality (the multivariable-adjusted HR: 1.59; 95% CI: 1.19–2.12; P-trend = 0.002). Among women with 5 y or longer of follow-up, women with high-carbohydrate intake recorded a higher risk of all-cause mortality; the multivariable-adjusted HR (95% CI) was 1.71 (0.93–3.13) for ≥65% of energy from carbohydrate compared with that for 50% to <55% (P-trend = 0.005). Men with high fat intake had a higher risk of cancer-related mortality; the multivariable-adjusted HR (95% CI) for ≥35% was 1.79 (1.11–2.90) compared with that for 20% to <25%. Fat intake was marginally inversely associated with risk of all-cause and cancer-related mortality in women (P-trend = 0.054 and 0.058, respectively). Conclusions: An unfavorable association with mortality is observed for low-carbohydrate intake in men and for high-carbohydrate intake in women. High fat intake can be associated with a lower mortality risk in women among Japanese adults with a relatively high-carbohydrate intake.

DOI： 10.1016/j.tjnut.2023.05.027

Association of daily physical activity and leisure-time exercise with dysphagia risk in community-dwelling older adults: a cross-sectional study 査読有り国際誌

Maehara, T; Nishimura, R; Yoshitake, A; Tsukamoto, M; Kadomatsu, Y; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Hishida, A; Takeuchi, K; Wakai, K; Naito, M

SCIENTIFIC REPORTS 13 巻 ( 1 ) 頁： 10893 - 10893 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

This study aimed to clarify the association of daily physical activity and leisure-time exercise with the risk of dysphagia in community-dwelling Japanese older adults using a questionnaire-based survey. We analyzed 3070 participants (1657 men, 1413 women; age 66 ± 4 years [mean ± SD]) of the Shizuoka and Daiko studies within the Japanese Multi-Institutional Collaborative Cohort study. We used the Dysphagia Risk Assessment for the Community-dwelling Elderly questionnaire to assess dysphagia risk and the International Physical Activity Questionnaire to assess daily physical activity and leisure-time exercise. Logistic regression analyses were used to evaluate the independent association of the amount of physical activity and leisure-time exercise with dysphagia risk. The proportion of participants with dysphagia risk was 27.5% (n = 844) and the risk was significantly higher in women (29.8%, n = 421) than in men (25.5%, n = 423; P = 0.008). Daily physical activity was not associated with dysphagia risk. A greater amount of leisure-time exercise was associated with lower dysphagia risk (P for trend = 0.003) and individuals in the highest leisure-time exercise quartile had a significantly lower odds ratio (0.68, 95% CI 0.52–0.89) than those in the lowest quartile, even after adjusting for the covariates.

DOI： 10.1038/s41598-023-37605-z

Comparison of the loci associated with HbA1c and blood glucose levels identified by a genome-wide association study in the Japanese population 査読有り

Sakashita, T; Nakamura, Y; Sutoh, Y; Shimizu, A; Hachiya, T; Otsuka-Yamasaki, Y; Takashima, N; Kadota, A; Miura, K; Kita, Y; Ikezaki, H; Otonari, J; Tanaka, K; Shimanoe, C; Koyama, T; Watanabe, I; Suzuki, S; Nakagawa-Senda, H; Hishida, A; Tamura, T; Kato, Y; Okada, R; Kuriki, K; Katsuura-Kamano, S; Watanabe, T; Tanoue, S; Koriyama, C; Oze, I; Koyanagi, YN; Nakamura, Y; Kusakabe, M; Nakatochi, M; Momozawa, Y; Wakai, K; Matsuo, K

DIABETOLOGY INTERNATIONAL 14 巻 ( 2 ) 頁： 188 - 198 2023年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Diabetology International

Aims: Hemoglobin A1c (HbA1c) levels are widely employed to diagnose diabetes. However, estimates of the heritability of HbA1c and glucose levels are different. Therefore, we explored HbA1c- and blood glucose-associated loci in a non-diabetic Japanese population. Methods: We conducted a two-stage genome-wide association study (GWAS) on variants associated with HbA1c and blood glucose levels in a Japanese population. In the initial stage, data of 4911 participants of the Japan Multi-Institutional Collaborative Cohort (J-MICC) were subjected to discovery analysis. In the second stage, two datasets from the Tohoku Medical Megabank project, with 8175 and 40,519 participants, were used for the replication study. Association of the imputed variants with HbA1c and blood glucose levels was determined via linear regression analyses adjusted for age, sex, body mass index (BMI), smoking, and genetic principal components (PC1–PC10). Moreover, we performed a BMI-stratified GWAS on HbA1c levels in the J-MICC. The discovery analysis and BMI-stratified GWAS results were validated with re-analyses of normalized HbA1c levels adjusted for site in addition to the above, and blood glucose adjusted for fasting time as an additional covariate. Results: Genetic variants associated with HbA1c levels were identified in KCNQ1 and TMC6. None of the genetic variants associated with blood glucose levels in the discovery analysis were replicated. Association of rs2299620 in KCNQ1 with HbA1c levels showed heterogeneity between individuals with BMI ≥ 25 kg/m2 and BMI < 25 kg/m2. Conclusions: The variant rs2299620 in KCNQ1 might affect HbA1c levels differentially based on BMI grouping in the Japanese population.

DOI： 10.1007/s13340-023-00618-0

質問紙で調査した成人の身体活動：日本多施設共同コーホート研究（J-MICC Study）

齋藤義信, 小熊祐子, 中村翔, 成松宏人, 中嶋綾子, 池崎裕昭, 田中恵太郎, 原めぐみ, 玉田雄大, 永吉真子, 田村高志, 菱田朝陽, 尾瀬功, 谷山祐香里, 三上春夫, 永瀬浩喜, 嶽﨑俊郎, 指宿りえ, 鈴木貞夫, 大谷隆浩, 小山晃英, 渡邉功, 栗木清典, 喜多義邦, 高嶋直敬, 有澤孝吉, 釜野桜子, 竹内研時, 若井建志, J-MICC研究グループ

運動疫学研究 25 巻 ( 1 ) 頁： 112 - 113 2023年3月

Coffee and metabolic phenotypes: A cross-sectional analysis of the Japan multi-institutional collaborative cohort (J-MICC) study 査読有り国際誌

Watanabe, T; Arisawa, K; Nguyen, TV; Ishizu, M; Katsuura-Kamano, S; Hishida, A; Tamura, T; Kato, Y; Okada, R; Ibusuki, R; Koriyama, C; Suzuki, S; Otani, T; Koyama, T; Tomida, S; Kuriki, K; Takashima, N; Miyagawa, N; Wakai, K; Matsuo, K

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 33 巻 ( 3 ) 頁： 620 - 630 2023年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nutrition, Metabolism and Cardiovascular Diseases

Background and aims: To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population. Methods and results: We analyzed the data of 26,363 subjects (aged 35–69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Coffee consumption was assessed using a questionnaire. Metabolic Syndrome (MetS) was defined according to the Joint Interim Statement Criteria of 2009, using body mass index (BMI) instead of waist circumference. Subjects stratified by the presence or absence of obesity (normal weight: BMI <25 kg/m2; obesity: BMI ≥25 kg/m2) were classified by the number of MetS components (metabolically healthy: no components; metabolically unhealthy: one or more components) other than BMI. In multiple logistic regression analyses adjusted for sex, age, and other potential confounders, high coffee consumption (≥3 cups/day) was associated with a lower prevalence of MetS and metabolically unhealthy phenotypes both in normal weight (OR 0.83, 95% CI 0.76–0.90) and obese subjects (OR 0.83, 95% CI 0.69–0.99). Filtered/instant coffee consumption was inversely associated with the prevalence of MetS and metabolically unhealthy phenotypes, whereas canned/bottled/packed coffee consumption was not. Conclusion: The present results suggest that high coffee consumption, particularly filtered/instant coffee, is inversely associated with the prevalence of metabolically unhealthy phenotypes in both normal weight and obese Japanese adults.

DOI： 10.1016/j.numecd.2022.12.019

Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis. 査読有り国際誌 Open Access

Nakamura S, Fang X, Saito Y, Narimatsu H, Ota A, Ikezaki H, Shimanoe C, Tanaka K, Kubo Y, Tsukamoto M, Tamura T, Hishida A, Oze I, Koyanagi YN, Nakamura Y, Kusakabe M, Takezaki T, Nishimoto D, Suzuki S, Otani T, Kuriyama N, Matsui D, Kuriki K, Kadota A, Nakamura Y, Arisawa K, Katsuura-Kamano S, Nakatochi M, Momozawa Y, Kubo M, Takeuchi K, Wakai K

PloS one 18 巻 ( 2 ) 頁： e0279169 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PLoS ONE

Background The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene–environment interactions, has been attracting attention in recent years. However, evidence for gene–environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene–lifestyle interactions in practice could aid in optimizing interventions according to genetic risk. Methods This study aimed to elucidate the effects of gene–lifestyle interactions on body mass index (BMI). Cross-sectional data from the Japan Multi-Institutional Collaborative Cohort Study were used. Interactions between a multi-locus genetic risk score (GRS), calculated from 76 ancestry-specific single nucleotide polymorphisms, and nutritional intake or physical activity were assessed using a linear mixed-effect model. Results The mean (standard deviation) BMI and GRS for all participants (n = 12,918) were 22.9 (3.0) kg/m2 and -0.07 (0.16), respectively. The correlation between GRS and BMI was r (12,916) = 0.13 (95% confidence interval [CI] 0.11–0.15, P < 0.001). An interaction between GRS and saturated fatty acid intake was observed (β = -0.11, 95% CI -0.21 to -0.02). An interaction between GRS and n-3 polyunsaturated fatty acids was also observed in the females with normal-weight subgroup (β = -0.12, 95% CI -0.22 to -0.03). Conclusion Our results provide evidence of an interaction effect between GRS and nutritional intake and physical activity. This gene–lifestyle interaction provides a basis for developing prevention or treatment interventions for obesity according to individual genetic predisposition.

DOI： 10.1371/journal.pone.0279169

Open Access