研究者詳細 - 田村　高志

論文 - 田村　高志

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Milk intake reduced the prevalence of hypertension by decreasing total arsenic levels in fasting serum in Japanese residents 査読有り国際誌

He, TC; Deng, YQ; Ohgami, N; Kagawa, T; Tazaki, A; Harusato, A; Ohnuma, S; Naito, H; Tamura, T; Wakai, K; Kato, M

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 302 巻頁： 118581 2025年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ecotoxicology and Environmental Safety

Background: Exposure to arsenic increases the risk of hypertension. Indeed, a high level of arsenic in human serum, a reliable biomarker of arsenic exposure, was shown to be linked to increased prevalence of hypertension among a study of Japanese residents. However, no beneficial food that decreases the risk of arsenic-mediated hypertension has been determined by considering intake scores of multiple foods. Methods: The comprehensive effects of combined beverage intake on the risk of hypertension, mediated by decreased levels of total arsenic in fasting serum, were investigated among the same group of 2706 residents. Results: Our generalized linear regression analysis for each beverage showed significant negative associations of serum arsenic levels with milk and vegetable juice intake scores among 11 beverages. Weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) analyses of combined beverage intake scores reveal that milk was the beverage most strongly associated with lower serum arsenic levels. Subsequent causal mediation analysis further showed that increased milk intake reduced the prevalence of arsenic-mediated hypertension by lowering serum arsenic levels. Additionally, our cell-free assay revealed the adsorption-modifying effect of milk on arsenic components in a popular fish meat. An in vivo assay confirmed that milk intake significantly decreased total serum arsenic levels in mice. Conclusions: Our multidisciplinary approach, combining epidemiological, chemical and animal studies, suggests that milk consumption has a beneficial effect in reducing the prevalence of arsenic-induced hypertension by decreasing arsenic absorption. Considering the global trend for increased consumption of fish meat with high levels of total arsenic, milk may be globally useful for reducing the risk of arsenic-mediated hypertension.

DOI： 10.1016/j.ecoenv.2025.118581

Inverse association between fruit juice consumption and type 2 diabetes among individuals with high genetic risk on type 2 diabetes: The J-MICC Study. 査読有り国際誌

Kawahara T, Nawa N, Oze I, Ikezaki H, Hara M, Kubo Y, Nagayoshi M, Ito H, Michihata N, Ibusuki R, Suzuki S, Ozaki E, Kuriki K, Takashima N, Katsuura-Kamano S, Nakatochi M, Momozawa Y, Tamura T, Fujiwara T, Matsuo K, J-MICC Study Group

The British journal of nutrition 頁： 1 - 23 2025年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：British Journal of Nutrition

Previous studies on the association between fruit juice consumption and type 2 diabetes remain controversial, which might be due to heterogeneity in the polygenic risk score (PRS) for type 2 diabetes. We examined the association between fruit juice and type 2 diabetes by PRS for type 2 diabetes. We investigated whether fruit juice influences type 2 diabetes risk differently among individuals with varying genetic risks. Data from the J-MICC (Japan Multi-Institutional Collaborative Cohort) study, a cross-sectional study of 13,769 Japanese individuals was used for our analysis. The primary exposure was the frequency of fruit juice, categorized as do not drink, less than 1 cup per day, or more than 1 cup per day. We selected PGS002379, a PRS for type 2 diabetes developed using East Asian populations. The primary outcome was physician-diagnosed type 2 diabetes, reported by participants. The consumption of fruit juice was significantly inversely associated with type 2 diabetes in the group with a high PRS for type 2 diabetes (OR: 0.78, 95%CI: 0.65 to 0.93 for <1 cup /day and OR: 0.54, 95%CI: 0.30 to 0.96 for >1/day), but this association was not observed in the low PRS group. Fruit juice consumption was inversely associated with type 2 diabetes, especially in genetically high-risk populations for type 2 diabetes.

DOI： 10.1017/S0007114525103863

Association of sex hormone-binding globulin and dyslipidemia with Japanese postmenopausal women: a cross-sectional study 査読有り国際誌

Ichikawa, T; Okada, H; Hamaguchi, M; Hara, M; Takashima, N; Suzuki, S; Tanoue, S; Kato, Y; Nagayoshi, M; Tamura, T; Fukui, M; Matsuo, K

LIPIDS IN HEALTH AND DISEASE 24 巻 ( 1 ) 頁： 212 2025年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lipids in Health and Disease

Background: In postmenopausal women, lower levels of sex hormone-binding globulin (SHBG) have been linked to various metabolic conditions. The association between SHBG levels and the presence of dyslipidemia was investigated in comparison with other sex hormones. Methods: Data from 570 postmenopausal women were analyzed. To assess the relationship between circulating sex hormone concentrations and dyslipidemia, logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the relationships. Results: Participants had a median age of 51.0 years (49.0–53.0). The multivariate analysis revealed that SHBG levels were significantly associated with dyslipidemia. Specifically, low SHBG levels correlated with hypertriglyceridemia and low high-density lipoprotein levels. The area under the curve (AUC) and the optimal SHBG level cutoff value for identifying the presence of dyslipidemia were 0.626 and 69.0 nmol/L, respectively. The AUCs for SHBG levels were highest for estradiol (E2), total testosterone (TT) and dehydroepiandrosterone sulfate (DHEAS) levels. Conclusions: SHBG levels were significantly associated with dyslipidemia in postmenopausal women and outperformed E2, TT, and DHEAS levels. These findings highlight SHBG as a potential biomarker for dyslipidemia risk in postmenopausal women, warranting further research into its prognostic utility.

DOI： 10.1186/s12944-025-02634-2

Association of Number of Teeth Present With Nutrient Intake and Food Group Consumption 査読有り国際誌

Asaeda, M; Nishimura, R; Suma, S; Tsukamoto, M; Kadomatsu, Y; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Hishida, A; Takeuchi, K; Goto, C; Imaeda, N; Wakai, K; Arimoto, N; Maehara, T; Naito, M

JOURNAL OF ORAL REHABILITATION 2025年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Oral Rehabilitation

Background: Several studies have examined the impact of tooth loss on nutrient intake, yielding mixed results. Objectives: This cross-sectional study aimed to investigate the association among the number of teeth present, nutrient intake and food group consumption in Japanese adults with no history of the four major diseases (diabetes, cancer, heart disease and stroke). Methods: Data were obtained from the baseline survey of the Japan Multi-Institutional Collaborative Cohort study conducted in the Shizuoka and Daiko areas. Participants completed a self-administered questionnaire on their number of teeth, medical history (diabetes, cancer, heart disease and stroke), education level, employment status and lifestyle factors, such as diet, smoking history and exercise habits. The number of teeth was classified into four groups: 0 teeth, 1–19 teeth, 20–27 teeth and 28–32 teeth. Results: A total of 8912 individuals included in the analysis had a mean age ± SD of 51.7 ± 9.5 years, with women accounting for 53.6% of the total. In adult men, the number of teeth was negatively associated with the intake of vitamin D, n-3 highly unsaturated fatty acid intake and seafood, while in women, bread consumption was positively associated with the number of teeth. Conclusions: These findings suggest that the number of teeth is independently associated with poor nutritional status in Japanese adults with no history of the four major diseases.

DOI： 10.1111/joor.14011

Comparison of polygenic risk scores for type 2 diabetes developed from different ancestry groups. 査読有り国際誌

Furukawa T, Hara M, Nishida Y, Tanaka K, Shimanoe C, Iwasaka C, Otonari J, Ikezaki H, Nagayoshi M, Tamura T, Tamada Y, Okada R, Oze I, Ito H, Michihata N, Nakamura Y, Tanoue S, Koriyama C, Suzuki S, Otani T, Watanabe I, Tomida S, Kuriki K, Takashima N, Kadota A, Ishizu M, Watanabe T, Nakatochi M, Momozawa Y, Wakai K, Matsuo K, Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group

npj metabolic health and disease.. 3 巻 ( 1 ) 頁： 17 2025年5月

Smoking behavior-related genetic variants and lung cancer risk in Japanese: an assessment by mediation analysis 査読有り国際誌

Yamamoto, S; Koyanagi, YN; Iwashita, Y; Shinozaki, T; Fujiwara, Y; Sakakura, N; Hara, M; Nishida, Y; Otonari, J; Ikezaki, H; Tanoue, S; Koriyama, C; Kasugai, Y; Oze, I; Koyama, T; Tomida, S; Michihata, N; Nakamura, Y; Suzuki, S; Nakagawa-Senda, H; Nagayoshi, M; Kubo, Y; Kato, Y; Wakai, K; Watanabe, T; Ishizu, M; Takashima, N; Kadota, A; Momozawa, Y; Nakatochi, M; Tamura, T; Niimi, A; Ito, H; Matsuo, K

CARCINOGENESIS 46 巻 ( 2 ) 2025年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Carcinogenesis

Cigarette smoking is one of the most important risk factors for lung cancer. Genetic studies have shown that smoking behavior-related genetic variants are directly associated with lung cancer, independent of smoking behavior, mainly in European populations. A recent genome-wide association study in Japan identified five loci associated with the number of cigarettes smoked per day. This study aimed to evaluate whether these loci are associated with lung cancer risk directly or indirectly through changing smoking behavior. Here, we conducted a case-control study (1427 cases and 5595 controls) and a prospective cohort study (128 incident cases in 10 520 subjects). Using mediation analysis, we decomposed the total effect of the lead single nucleotide polymorphism (SNP) at each locus on lung cancer risk into direct and indirect effects. The results of the two studies were pooled using a random-effects model to estimate summary relative risks (RRs) and their 95% confidence intervals (CIs). Two studies showed that: (i) rs78277894 (EPHX2-CLU, G > A) had a protective direct effect (RR: 0.84; 95% CI: 0.77-0.93) on lung cancer risk; and (ii) rs56129017 (CYP2A6, C > T) had carcinogenic direct and indirect effects on lung cancer risk (RR: 1.26; 95% CI: 1.15-1.39 and RR: 1.01; 95% CI: 1.00-1.01, respectively). This mediation analysis revealed that two smoking behavior-related SNPs, EPHX2-CLU rs78277894 and CYP2A6 rs56129017, were associated with lung cancer risk through pathways independent of changing smoking behavior. Our findings may contribute to our understanding of lung carcinogenesis pathways that cannot be addressed by changes in smoking behavior.

DOI： 10.1093/carcin/bgaf011

Dairy Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk in A Large Japanese Population: A 12-Year Follow-Up of the J-MICC Study 査読有り Open Access

Miyagawa, N; Takashima, N; Harada, A; Kadota, A; Kondo, K; Miura, K; Imaeda, N; Goto, C; Otonari, J; Ikezaki, H; Tanaka, K; Shimanoe, C; Nagayoshi, M; Tamura, T; Kubo, Y; Kato, Y; Koyanagi, YN; Ito, H; Michihata, N; Nakamura, Y; Tanoue, S; Ibusuki, R; Suzuki, S; Nishiyama, T; Ozaki, E; Watanabe, I; Kuriki, K; Watanabe, T; Ishizu, M; Hishida, A; Kita, Y; Wakai, K; Matsuo, K

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 32 巻 ( 5 ) 頁： 596 - 607 2025年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Atherosclerosis and Thrombosis

Aim: We examined the association between dairy intake and all-cause, cancer, and cardiovascular disease mortality in a cohort of the general population followed up for 12 years across Japan. Methods: We conducted a longitudinal cohort study of 79,715 participants from the Japan Multi-Institutional Collaborative Cohort study (57.2% women, mean age 54.7 years old). The amount of dairy (milk and yogurt) intake was determined using a validated short-food frequency questionnaire. The hazard ratio for mortality according to sex-specific tertile of dairy intake was calculated using Cox proportional hazards regression models with adjustment for potential confounding factors and dietary factors by sex. Results: During the follow-up period (932,738 person-years), 3,723 participants died, including 2,088 cancer and 530 cardiovascular disease deaths. The highest tertile of total dairy intake (versus the lowest tertile) was associated with a 19% lower all-cause mortality risk (hazard ratio =0.81, 95% confidence interval: 0.70-0.92; P for trend=0.001) in women. Similarly, we observed inverse associations between milk intake and all-cause and cancer mortality risk in women, yogurt intake and cardiovascular disease risk in women, and yogurt intake and all-cause mortality risk in both sexes. Conclusion: A higher total dairy and milk intakes in women and yogurt intake in both sexes were associated with a reduced risk of all-cause mortality in the general population across Japan during the 12-year follow-up period.

DOI： 10.5551/jat.65049

The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort Study 査読有り国際誌

Watanabe, T; Nguyen, TV; Katsuura-Kamano, S; Arisawa, K; Ishizu, M; Unohara, T; Tanaka, K; Shimanoe, C; Nagayoshi, M; Tamura, T; Kubo, Y; Kato, Y; Oze, I; Ito, H; Michihata, N; Nakamura, Y; Tanoue, S; Koriyama, C; Suzuki, S; Nakagawa-Senda, H; Koyama, T; Tomida, S; Kuriki, K; Takashima, N; Harada, A; Wakai, K; Matsuo, K

CANCER RESEARCH COMMUNICATIONS 4 巻 ( 11 ) 頁： 2986 - 2997 2024年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancer Research Communications

The present study investigated the relationship between metabolic phenotypes and the risk of cancer in a Japanese population using the criteria of metabolic phenotypes based on an examination and those based on questionnaires. We used data from 25,357 subjects for examination-based analyses and those from 53,042 subjects for questionnaire-based analyses in the Japan Multi-institutional Collaborative Cohort study. Metabolic phenotypes were defined by classifying subjects according to their body mass index (BMI; obesity: BMI ≥25 kg/m<sup>2</sup>; normal weight: BMI <25 kg/m<sup>2</sup>) and the number of metabolic abnormalities. Metabolic abnormalities were defined according to metabolic syndrome components of the Joint Interim Statement criteria for examination-based analyses and self-reported histories of diabetes, dyslipidemia, and hypertension for questionnaire-based analyses. Cox proportional hazards regression analyses adjusted for potential confounders were performed for total and site-specific cancer incidence rates according to metabolic phenotypes. Metabolically unhealthy obesity (MUHO) was significantly associated with cancer incidence in both examination-based [HR (95% confidence interval), 1.17 (1.01–1.36)] and questionnaire-based analyses [HR (95% confidence interval), 1.15 (1.04–1.26)]. Regarding site-specific cancer in questionnaire-based analyses, metabolically healthy obesity and MUHO were associated with colorectum and liver cancers in all subjects and with breast cancer in female subjects. Subjects with a metabolically unhealthy normal weight had a higher risk of pancreatic cancer. Moreover, MUHO was associated with corpus uteri cancer in female subjects. This prospective cohort study suggests that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Significance: The prospective cohort study in a large Japanese population suggested that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Moreover, the risk of each site-specific cancer may differ according to metabolic phenotypes.

DOI： 10.1158/2767-9764.CRC-24-0249

Food group intakes and high-sensitivity C-reactive protein among community-dwelling Japanese adults: a cross-sectional study 査読有り国際誌

Matsunaga, T; Wakai, K; Imaeda, N; Goto, C; Tamada, Y; Kato, Y; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Hishida, A; Ikezaki, H; Otonari, J; Takashima, N; Miyagawa, N; Matsuo, K

PUBLIC HEALTH NUTRITION 27 巻 ( 1 ) 頁： e212 2024年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Public Health Nutrition

Objective: Healthy dietary patterns have been linked to lower levels of chronic inflammation. The present study aimed to investigate the associations between food group intakes and high-sensitivity C-reactive protein (hsCRP) among community-dwelling adults. Design: Cross-sectional. Setting: Three areas in Japan (Shiga, Fukuoka, or Kyushu and Okinawa). Participants: The present analysis included 13 648 participants (5126 males and 8522 females; age range, 35-69 years) who had been enrolled in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Food group intakes were estimated using a FFQ. Multiple linear regression was used to examine associations between the quartiles of each energy-adjusted food group intake and log-transformed hsCRP. Results: The following concentration ratios of hsCRP after comparing the highest and lowest quartiles of food group intake were significant: in males, 1.12 (95 % CI 1.02, 1.22) for processed meat, 1.13 (95 % CI 1.03, 1.24) for fish and 0.83 (95 % CI 0.76, 0.90) for nuts; in females, 0.89 (95 % CI 0.81, 0.97) for bread, 1.11 (95 % CI 1.03, 1.19) for processed meat, 0.86 (95 % CI 0.80, 0.92) for vegetables, 1.19 (95 % CI 1.11, 1.29) for fruit, 0.90 (95 % CI 0.84, 0.97) for nuts and 0.88 (95 % CI 0.82, 0.95) for green tea. Conclusions: Processed meat and nut intakes were associated with higher and lower hsCRP levels, respectively, in both sexes. However, for several food groups, including fish and fruit, previous findings from dietary pattern analyses were not supported by the present analyses at the food group level.

DOI： 10.1017/S1368980024001599

Polygenic risk score for blood pressure and lifestyle factors with overall and CVD mortality: a prospective cohort study in a Japanese population 査読有り国際誌

Fujii, R; Hishida, A; Nakatochi, M; Okumiyama, H; Takashima, N; Tsuboi, Y; Suzuki, K; Ikezaki, H; Shimanoe, C; Kato, Y; Tamura, T; Ito, H; Michihata, N; Tanoue, S; Suzuki, S; Kuriki, K; Kadota, A; Watanabe, T; Momozawa, Y; Wakai, K; Matsuo, K; Matsuo, K

HYPERTENSION RESEARCH 47 巻 ( 9 ) 頁： 2284 - 2294 2024年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Hypertension Research

Although previous polygenic risk score (PRS) studies for cardiovascular disease (CVD) focused on incidence, few studies addressed CVD mortality and quantified risks by environmental exposures in different genetic liability groups. This prospective study aimed to examine the associations of blood pressure PRS with all-cause and CVD mortality and to quantify the attributable risk by modifiable lifestyles across different PRS strata. 9,296 participants in the Japan Multi-Institutional Collaborative Cohort Study without hypertension at baseline were analyzed in this analysis. PRS for systolic blood pressure and diastolic blood pressure (PRS<inf>SBP</inf> and PRS<inf>DBP</inf>) were developed using publicly available Biobank Japan GWAS summary statistics. CVD-related mortality was defined by the International Classification of Diseases 10th version (I00-I99). Cox-proportional hazard model was used to examine associations of PRSs and lifestyle variables (smoking, drinking, and dietary sodium intake) with mortality. During a median 12.6-year follow-up period, we observed 273 all-cause and 41 CVD mortality cases. Compared to the middle PRS group (20–80th percentile), adjusted hazard ratios for CVD mortality at the top PRS group (> 90th percentile) were 3.67 for PRS<inf>SBP</inf> and 2.92 for PRS<inf>DBP</inf>. Attributable risks of CVD mortality by modifiable lifestyles were higher in the high PRS group (> 80th percentile) compared with the low PRS group (0–80th percentile). In summary, blood pressure PRS is associated with CVD mortality in the general Japanese population. Our study implies that integrating PRS with lifestyle could contribute to identify target populations for lifestyle intervention even though improvement of discriminatory ability by PRS alone is limited. (Figure presented.)

DOI： 10.1038/s41440-024-01766-9

Association between dysphagia risk and sleep quality in community-dwelling older adults: A cross-sectional study 査読有り国際誌

Hama, Y; Yamada, S; Nishimura, R; Yoshida, M; Tsuga, K; Morita, E; Tamada, Y; Kato, Y; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Hishida, A; Wakai, K; Naito, M

HELIYON 10 巻 ( 11 ) 頁： e32028 2024年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Heliyon

Objectives: Exploring the effects of swallowing function on sleep quality could provide valuable insights into the potential impact of reduced swallowing function on sleep. However, pertinent studies are limited. Therefore, this study aimed to investigate the relationship between dysphagia risk and sleep health in community-dwelling older adults. Methods: Data for this cross-sectional study were obtained from the Shizuoka and Daiko studies conducted as part of the Japan Multi-Institutional Collaborative Cohort Study. Information on demographics, overall lifestyle, dysphagia risk, as well as sleep quality, duration, satisfaction, and regularity, was obtained using a self-administered questionnaire. Dysphagia risk and sleep quality were assessed using the Dysphagia Risk Assessment Questionnaire for the Community-dwelling Elderly and the Japanese version of the Pittsburgh Sleep Questionnaire Index, respectively. Multivariate logistic regression, adjusted for covariates, was employed to assess the association between dysphagia risk and sleep health. Results: Among the 3058 participants (1633 males, 1425 females) aged ≥60 years, 28.0 % exhibited dysphagia risk, and 19.1 % reported poor sleep quality. Those with dysphagia risk were more likely to experience poor sleep quality than those without dysphagia risk. In male participants, dysphagia was significantly associated with poor sleep quality, unsatisfactory sleep, and sleep irregularity, but was not significantly associated with unsatisfactory or irregular sleep in female participants. The Japanese version of the Pittsburgh Sleep Questionnaire Index components—subjective sleep quality, sleep latency, sleep disturbances, and daytime dysfunction—were associated with dysphagia risk in both sexes. Conclusions: Dysphagia risk is associated with sleep quality in older individuals in Japan. Thus, preserving swallowing function may contribute to enhancing sleep quality.

DOI： 10.1016/j.heliyon.2024.e32028

Association between awareness of limiting food intake and all-cause mortality: A cohort study in Japan. 査読有り

Nishimoto D, Ibusuki R, Shimoshikiryo I, Shibuya K, Tanoue S, Koriyama C, Takezaki T, Oze I, Ito H, Hishida A, Tamura T, Kato Y, Tamada Y, Nishida Y, Shimanoe C, Suzuki S, Nishiyama T, Ozaki E, Tomida S, Kuriki K, Miyagawa N, Kondo K, Arisawa K, Watanabe T, Ikezaki H, Otonari J, Wakai K, Matsuo K

Journal of epidemiology 34 巻 ( 0 ) 頁： 286 - 294 2024年6月

Elevated level of urinary tellurium is a potential risk for increase of blood pressure in humans and mice 査読有り国際誌

Misawa, T; Kagawa, T; Ohgami, N; Tazaki, A; Ohnuma, S; Naito, H; Chen, DJ; Gu, YS; Tamura, T; Wakai, K; Nishiwaki, K; Kato, M

ENVIRONMENT INTERNATIONAL 188 巻頁： 108735 - 108735 2024年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Environment International

Background: People worldwide are routinely exposed to tellurium mainly via dietary ingestion. There has been no study to clarify the contribution of tellurium to blood pressure in humans or animals. Methods: In this cross-sectional study conducted in a general population of 2592 residents in Japan, the associations of urinary tellurium levels with blood pressure and prevalence of hypertension were investigated. The potential sources of tellurium were also investigated. An interventional study in mice confirmed the effect of tellurium exposure on blood pressure. Results: Linear and logistic regression analyses with consideration of confounders including urinary sodium–potassium ratio showed significant positive associations of urinary tellurium level with prevalence of hypertension and blood pressure. Cereals/beans and vegetables/fruits were determined to be potential dietary sources of tellurium exposure. Intermediary analysis suggested that increased intake of cereals/beans, but not that of vegetables/fruits, is positively associated with the tellurium-mediated risk of hypertension. Correspondingly, the mouse study showed that exposure to a putative human-equivalent dose of tellurium via drinking water increased blood pressure with an elevated level of urinary tellurium. The temporally increased blood pressure was decreased to the normal level by a break of tellurium exposure with a reduced level of urinary tellurium. Conclusions: The interdisciplinary approach provided the first evidence that tellurium exposure is a potential risk for increase of blood pressure. Since the human urinary tellurium level in this study is comparable with the levels in general populations in other Asian and European countries in previous studies, exposure to tellurium may be a latent universal risk for hypertension.

DOI： 10.1016/j.envint.2024.108735

GWAS of folate metabolism with gene-environment interaction analysis revealed the possible role of lifestyles in the control of blood folate metabolites in Japanese-the J-MICC Study. 査読有り

Tsukamoto, M; Hishida, A; Tamura, T; Nagayoshi, M; Okada, R; Kubo, Y; Kato, Y; Hamajima, N; Nishida, Y; Shimanoe, C; Ibusuki, R; Shibuya, K; Takashima, N; Nakamura, Y; Kusakabe, M; Nakamura, Y; Koyanagi, YN; Oze, I; Nishiyama, T; Suzuki, S; Watanabe, I; Matsui, D; Otonari, J; Ikezaki, H; Katsuura-Kamano, S; Arisawa, K; Kuriki, K; Nakatochi, M; Momozawa, Y; Takeuchi, K; Wakai, K; Matsuo, K

JOURNAL OF EPIDEMIOLOGY 34 巻頁： 228 - 237 2024年5月

Association between consumption of small fish and all-cause mortality among Japanese: the Japan Multi-Institutional Collaborative Cohort Study 査読有り国際誌

Kasahara, C; Tamura, T; Wakai, K; Tamada, Y; Kato, Y; Kubo, Y; Okada, R; Nagayoshi, M; Hishida, A; Imaeda, N; Goto, C; Otonari, J; Ikezaki, H; Nishida, Y; Shimanoe, C; Oze, I; Koyanagi, YN; Nakamura, Y; Kusakabe, M; Nishimoto, D; Shimoshikiryo, I; Suzuki, S; Watanabe, M; Ozaki, E; Omichi, C; Kuriki, K; Takashima, N; Miyagawa, N; Arisawa, K; Katsuura-Kamano, S; Takeuchi, K; Matsuo, K

PUBLIC HEALTH NUTRITION 27 巻 ( 1 ) 頁： e135 - 40 2024年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Public Health Nutrition

Objective: Although small fish are an important source of micronutrients, the relationship between their intake and mortality remains unclear. This study aimed to clarify the association between intake of small fish and all-cause and cause-specific mortality. Design: We used the data from a cohort study in Japan. The frequency of the intake of small fish was assessed using a validated FFQ. The hazard ratio (HR) and 95 % confidence interval (CI) for all-cause and cause-specific mortality according to the frequency of the intake of small fish by sex were estimated using a Cox proportional hazard model with adjustments for covariates. Setting: The Japan Multi-Institutional Collaborative Cohort Study. Participants: A total of 80 802 participants (34 555 males and 46 247 females), aged 35-69 years. Results: During a mean follow-up of 9·0 years, we identified 2482 deaths including 1495 cancer-related deaths. The intake of small fish was statistically significantly and inversely associated with the risk of all-cause and cancer mortality in females. The multivariable-adjusted HR (95 % CI) in females for all-cause mortality according to the intake were 0·68 (0·55, 0·85) for intakes 1-3 times/month, 0·72 (0·57, 0·90) for 1-2 times/week and 0·69 (0·54, 0·88) for ≥ 3 times/week, compared with the rare intake. The corresponding HR (95 % CI) in females for cancer mortality were 0·72 (0·54, 0·96), 0·71 (0·53, 0·96) and 0·64 (0·46, 0·89), respectively. No statistically significant association was observed in males. Conclusions: Intake of small fish may reduce the risk of all-cause and cancer mortality in Japanese females.

DOI： 10.1017/S1368980024000831

The Inverse Association between the Frequency of Forest Walking (Shinrin-yoku) and the Prevalence of Insomnia Symptoms in the General Japanese Population: A Japan Multi-Institutional Collaborative Cohort Daiko Study. 査読有り国際誌 Open Access

Morita E, Kadotani H, Yamada N, Sasakabe T, Kawai S, Naito M, Tamura T, Wakai K

International journal of environmental research and public health 21 巻 ( 3 ) 2024年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：International Journal of Environmental Research and Public Health

Since a single forest walk (Shinrin-yoku or forest bathing) session is reported to improve sleep temporarily, occasional forest walks may have a positive effect on daily sleep. Therefore, this study aimed to examine whether more frequent forest walking is associated with better daily sleep conditions. Data from the second survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Daiko Study conducted among residents of Nagoya City, Japan, were used. The study design was a cross-sectional study. In total, 2044 participants (529 men and 1515 women; age, mean ± standard deviation: 58.8 ± 9.9 years) were included in the analysis. Frequent forest walks were associated with a low percentage of insomnia symptoms (Insomnia Severity Index ≥10) in women, but not in men. The adjusted odds ratio for the group that rarely took forest walks with reference to the group that engaged in the activity once a month or more often was 2.04 (95% confidence interval: 1.29–3.23) in women. Forest walk frequency was not significantly associated with sleep duration or sleep efficiency as measured by actigraphy in either men or women. In conclusion, the results suggested that increasing the frequency of forest walks or Shinrin-yoku may be effective in preventing insomnia in women.

DOI： 10.3390/ijerph21030350

BMI and cardiometabolic traits in Japanese: a Mendelian randomization study 査読有り

Nagayoshi, M; Hishida, A; Shimizu, T; Kato, Y; Kubo, Y; Okada, R; Tamura, T; Otonari, J; Ikezaki, H; Hara, M; Nishida, Y; Oze, I; Koyanagi, YN; Nakamura, Y; Kusakabe, M; Ibusuki, R; Shibuya, K; Suzuki, S; Nishiyama, T; Koyama, T; Ozaki, E; Kuriki, K; Takashima, N; Nakamura, Y; Katsuura-Kamanos, S; Arisawa, K; Nakatochi, M; Momozawa, Y; Takeuchi, K; Wakai, K; J-MICC Study Grp

JOURNAL OF EPIDEMIOLOGY 34 巻頁： 51 - 62 2024年2月

Seven-plus hours of daily sedentary time and the subsequent risk of breast cancer: Japan Multi-Institutional Collaborative Cohort Study 査読有り

Tomida, S; Koyama, T; Ozaki, E; Takashima, N; Morita, M; Sakaguchi, K; Naoi, Y; Nishida, Y; Hara, M; Hishida, A; Tamura, T; Okada, R; Kubo, Y; Otonari, J; Ikezaki, H; Nakamura, Y; Kusakabe, M; Tanoue, S; Koriyama, C; Koyanagi, YN; Ito, H; Suzuki, S; Otani, T; Miyagawa, N; Okami, Y; Arisawa, K; Watanabe, T; Kuriki, K; Wakai, K; Matsuo, K

CANCER SCIENCE 115 巻頁： 611 - 622 2024年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Cancer Science

This study aimed to investigate the association between daily sedentary time and the risk of breast cancer (BC) in a large Japanese population. The participants were 36,023 women aged 35–69 years from the Japan Multi-Institutional Collaborative Cohort Study. Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for BC incidence in relation to time spent sedentarily (categorical variables: <7 and ≥7 hours/day [h/d]). Additionally, the associations of BC incidence to the joint effect of sedentary time with each component of physical activity, such as leisure-time metabolic equivalents (METs), frequency of leisure-time physical activity, and daily walking time, were examined. During 315,189 person-years of follow-up, 554 incident cases of BC were identified. When compared to participants who spent <7 h/d sedentary, those who spent ≥7 h/d sedentary have a significantly higher risk of BC (HR, 1.36; 95% CI, 1.07–1.71). The corresponding HRs among participants who spent ≥7 h/d sedentary with more physical activity, such as ≥1 h/d for leisure-time METs, ≥3 days/week of leisure-time physical activity, and ≥1 h/d of daily walking were 1.58 (95% CI, 1.11–2.25), 1.77 (95% CI, 1.20–2.61), and 1.42 (95% CI, 1.10–1.83), respectively, compared with those who spent <7 h/d sedentary. This study found that spending ≥7 h/d of sedentary time is associated with the risk of BC. Neither leisure-time physical activity nor walking had a BC-preventive effect in those with ≥7 h/d of sedentary time.

DOI： 10.1111/cas.16020

Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice 査読有り国際誌 Open Access

Kagawa, T; Ohgami, N; He, T; Tazaki, A; Ohnuma, S; Naito, H; Yajima, I; Chen, D; Deng, Y; Tamura, T; Kondo, T; Wakai, K; Kato, M

EUROPEAN HEART JOURNAL OPEN 3 巻 ( 5 ) 頁： oead074 2023年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Heart Journal Open

Aims: There has been a shortage of human studies to elucidate the association between serum arsenic levels and the prevalence of hypertension. This study multidirectionally investigated associations among arsenic exposure, dietary ingestion, and the risk of hypertension by combined human epidemiological and mouse experimental studies. Methods and results: This study focused on the total arsenic level in fasting serum, a biomarker of arsenic exposure. Associations among ingestion frequencies of 54 diet items of Japanese food separated into six categories, total arsenic level in fasting serum, and the prevalence of hypertension were investigated in 2709 general people in Japan. Logistic regression analysis demonstrated a dose-dependent association between serum arsenic level and hypertension and a positive association between the ingestion of fish meat and hypertension. Further analysis showed that the latter association was fully mediated by increased fasting serum arsenic levels in humans. Similarly, oral exposure to the putative human-equivalent dose of arsenic species mixture with the same ratios in a common fish meat in Japan increased systolic blood pressure and arsenic levels in fasting serum in mice. Conclusion: This interdisciplinary approach suggests that fish-meat ingestion is a potential risk factor for arsenic-mediated hypertension. Because the increased consumption of fish meat is a recent global trend, health risks of the increased ingestion of arsenic via fish meat should be further investigated.

DOI： 10.1093/ehjopen/oead074

Dietary Carbohydrate and Fat Intakes and Risk of Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study 査読有り国際誌

Tamura, T; Wakai, K; Kato, Y; Tamada, Y; Kubo, Y; Okada, R; Nagayoshi, M; Hishida, A; Imaeda, N; Goto, C; Ikezaki, H; Otonari, J; Hara, M; Tanaka, K; Nakamura, Y; Kusakabe, M; Ibusuki, R; Koriyama, C; Oze, I; Ito, H; Suzuki, S; Nakagawa-Senda, H; Ozaki, E; Matsui, D; Kuriki, K; Kondo, K; Takashima, N; Watanabe, T; Katsuura-Kamano, S; Matsuo, K

JOURNAL OF NUTRITION 153 巻 ( 8 ) 頁： 2352 - 2368 2023年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Journal of Nutrition

Background: Previous cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality. Objectives: We examined long-term associations of carbohydrate and fat intakes with mortality. Methods: In this cohort study, 34,893 men and 46,440 women aged 35–69 y (mean body mass index of 23.7 and 22.2 kg/m2, respectively) were followed up from the baseline survey (2004–2014) to the end of 2017 or 2018. Intakes of carbohydrate, fat, and total energy were estimated using a food frequency questionnaire. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for all-cause and cause-specific mortality according to percentage of energy intakes of carbohydrate and fat. Results: During a mean 8.9-y follow-up, we identified 2783 deaths (1838 men and 945 women). Compared with men who consumed 50% to <55% of energy from carbohydrate, those who consumed <40% carbohydrate energy experienced a significantly higher risk of all-cause mortality (the multivariable-adjusted HR: 1.59; 95% CI: 1.19–2.12; P-trend = 0.002). Among women with 5 y or longer of follow-up, women with high-carbohydrate intake recorded a higher risk of all-cause mortality; the multivariable-adjusted HR (95% CI) was 1.71 (0.93–3.13) for ≥65% of energy from carbohydrate compared with that for 50% to <55% (P-trend = 0.005). Men with high fat intake had a higher risk of cancer-related mortality; the multivariable-adjusted HR (95% CI) for ≥35% was 1.79 (1.11–2.90) compared with that for 20% to <25%. Fat intake was marginally inversely associated with risk of all-cause and cancer-related mortality in women (P-trend = 0.054 and 0.058, respectively). Conclusions: An unfavorable association with mortality is observed for low-carbohydrate intake in men and for high-carbohydrate intake in women. High fat intake can be associated with a lower mortality risk in women among Japanese adults with a relatively high-carbohydrate intake.

DOI： 10.1016/j.tjnut.2023.05.027

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