2025/06/09 更新

写真a

タムラ タカシ
田村 高志
TAMURA Takashi
所属
大学院医学系研究科 総合医学専攻 社会生命科学 准教授
大学院担当
大学院医学系研究科
学部担当
医学部 医学科
職名
准教授
連絡先
メールアドレス
外部リンク

学位 1

  1. 博士(医学) ( 2014年3月   名古屋大学 ) 

研究キーワード 1

  1. コホート研究、症例対照研究、栄養疫学、分子疫学、がん・生活習慣病

現在の研究課題とSDGs 3

  1. 分子疫学

  2. 栄養疫学

  3. がん疫学

経歴 6

  1. 名古屋大学   大学院医学系研究科 総合医学専攻 社会生命科学講座 予防医学分野   准教授

    2024年5月 - 現在

  2. 名古屋大学   大学院医学系研究科 総合医学専攻 社会生命科学講座 予防医学分野   講師

    2021年11月 - 2024年4月

  3. 名古屋大学   大学院医学系研究科 附属医学教育研究支援センター 先端領域支援部門   特任助教

    2020年4月 - 2021年11月

  4. 名古屋大学   大学院医学系研究科 総合医学専攻 社会生命科学講座 予防医学分野   特任助教

    2018年10月 - 2020年3月

  5. 名古屋大学   大学院医学系研究科 総合医学専攻 社会生命科学講座 予防医学分野   研究員

    2017年8月 - 2018年9月

▼全件表示

学歴 3

  1. 名古屋大学   大学院医学系研究科 博士課程(医学)健康社会医学専攻 予防医学分野

    2011年4月 - 2014年3月

  2. 名古屋大学   大学院医学系研究科 修士課程(医科学)医科学専攻 予防医学分野

    2009年4月 - 2011年3月

  3. 北陸大学   薬学部 薬学科

    2004年4月 - 2008年3月

所属学協会 4

  1. 日本疫学会

  2. 日本癌学会

  3. 日本がん疫学・分子疫学研究会

  4. 東海公衆衛生学会

 

論文 103

  1. Association of Number of Teeth Present With Nutrient Intake and Food Group Consumption 査読有り 国際誌

    Asaeda, M; Nishimura, R; Suma, S; Tsukamoto, M; Kadomatsu, Y; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Hishida, A; Takeuchi, K; Goto, C; Imaeda, N; Wakai, K; Arimoto, N; Maehara, T; Naito, M

    JOURNAL OF ORAL REHABILITATION     2025年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Oral Rehabilitation  

    Background: Several studies have examined the impact of tooth loss on nutrient intake, yielding mixed results. Objectives: This cross-sectional study aimed to investigate the association among the number of teeth present, nutrient intake and food group consumption in Japanese adults with no history of the four major diseases (diabetes, cancer, heart disease and stroke). Methods: Data were obtained from the baseline survey of the Japan Multi-Institutional Collaborative Cohort study conducted in the Shizuoka and Daiko areas. Participants completed a self-administered questionnaire on their number of teeth, medical history (diabetes, cancer, heart disease and stroke), education level, employment status and lifestyle factors, such as diet, smoking history and exercise habits. The number of teeth was classified into four groups: 0 teeth, 1–19 teeth, 20–27 teeth and 28–32 teeth. Results: A total of 8912 individuals included in the analysis had a mean age ± SD of 51.7 ± 9.5 years, with women accounting for 53.6% of the total. In adult men, the number of teeth was negatively associated with the intake of vitamin D, n-3 highly unsaturated fatty acid intake and seafood, while in women, bread consumption was positively associated with the number of teeth. Conclusions: These findings suggest that the number of teeth is independently associated with poor nutritional status in Japanese adults with no history of the four major diseases.

    DOI: 10.1111/joor.14011

    Web of Science

    Scopus

    PubMed

  2. Smoking behavior-related genetic variants and lung cancer risk in Japanese: an assessment by mediation analysis 査読有り 国際誌

    Yamamoto, S; Koyanagi, YN; Iwashita, Y; Shinozaki, T; Fujiwara, Y; Sakakura, N; Hara, M; Nishida, Y; Otonari, J; Ikezaki, H; Tanoue, S; Koriyama, C; Kasugai, Y; Oze, I; Koyama, T; Tomida, S; Michihata, N; Nakamura, Y; Suzuki, S; Nakagawa-Senda, H; Nagayoshi, M; Kubo, Y; Kato, Y; Wakai, K; Watanabe, T; Ishizu, M; Takashima, N; Kadota, A; Momozawa, Y; Nakatochi, M; Tamura, T; Niimi, A; Ito, H; Matsuo, K

    CARCINOGENESIS   46 巻 ( 2 )   2025年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Carcinogenesis  

    Cigarette smoking is one of the most important risk factors for lung cancer. Genetic studies have shown that smoking behavior-related genetic variants are directly associated with lung cancer, independent of smoking behavior, mainly in European populations. A recent genome-wide association study in Japan identified five loci associated with the number of cigarettes smoked per day. This study aimed to evaluate whether these loci are associated with lung cancer risk directly or indirectly through changing smoking behavior. Here, we conducted a case-control study (1427 cases and 5595 controls) and a prospective cohort study (128 incident cases in 10 520 subjects). Using mediation analysis, we decomposed the total effect of the lead single nucleotide polymorphism (SNP) at each locus on lung cancer risk into direct and indirect effects. The results of the two studies were pooled using a random-effects model to estimate summary relative risks (RRs) and their 95% confidence intervals (CIs). Two studies showed that: (i) rs78277894 (EPHX2-CLU, G > A) had a protective direct effect (RR: 0.84; 95% CI: 0.77-0.93) on lung cancer risk; and (ii) rs56129017 (CYP2A6, C > T) had carcinogenic direct and indirect effects on lung cancer risk (RR: 1.26; 95% CI: 1.15-1.39 and RR: 1.01; 95% CI: 1.00-1.01, respectively). This mediation analysis revealed that two smoking behavior-related SNPs, EPHX2-CLU rs78277894 and CYP2A6 rs56129017, were associated with lung cancer risk through pathways independent of changing smoking behavior. Our findings may contribute to our understanding of lung carcinogenesis pathways that cannot be addressed by changes in smoking behavior.

    DOI: 10.1093/carcin/bgaf011

    Web of Science

    Scopus

    PubMed

  3. Dairy Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk in A Large Japanese Population: A 12-Year Follow-Up of the J-MICC Study 査読有り Open Access

    Miyagawa, N; Takashima, N; Harada, A; Kadota, A; Kondo, K; Miura, K; Imaeda, N; Goto, C; Otonari, J; Ikezaki, H; Tanaka, K; Shimanoe, C; Nagayoshi, M; Tamura, T; Kubo, Y; Kato, Y; Koyanagi, YN; Ito, H; Michihata, N; Nakamura, Y; Tanoue, S; Ibusuki, R; Suzuki, S; Nishiyama, T; Ozaki, E; Watanabe, I; Kuriki, K; Watanabe, T; Ishizu, M; Hishida, A; Kita, Y; Wakai, K; Matsuo, K

    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   32 巻 ( 5 ) 頁: 596 - 607   2025年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Journal of Atherosclerosis and Thrombosis  

    Aim: We examined the association between dairy intake and all-cause, cancer, and cardiovascular disease mortality in a cohort of the general population followed up for 12 years across Japan. Methods: We conducted a longitudinal cohort study of 79,715 participants from the Japan Multi-Institutional Collaborative Cohort study (57.2% women, mean age 54.7 years old). The amount of dairy (milk and yogurt) intake was determined using a validated short-food frequency questionnaire. The hazard ratio for mortality according to sex-specific tertile of dairy intake was calculated using Cox proportional hazards regression models with adjustment for potential confounding factors and dietary factors by sex. Results: During the follow-up period (932,738 person-years), 3,723 participants died, including 2,088 cancer and 530 cardiovascular disease deaths. The highest tertile of total dairy intake (versus the lowest tertile) was associated with a 19% lower all-cause mortality risk (hazard ratio =0.81, 95% confidence interval: 0.70-0.92; P for trend=0.001) in women. Similarly, we observed inverse associations between milk intake and all-cause and cancer mortality risk in women, yogurt intake and cardiovascular disease risk in women, and yogurt intake and all-cause mortality risk in both sexes. Conclusion: A higher total dairy and milk intakes in women and yogurt intake in both sexes were associated with a reduced risk of all-cause mortality in the general population across Japan during the 12-year follow-up period.

    DOI: 10.5551/jat.65049

    Open Access

    Web of Science

    Scopus

    PubMed

    CiNii Research

  4. The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort Study 査読有り 国際誌 Open Access

    Watanabe, T; Nguyen, TV; Katsuura-Kamano, S; Arisawa, K; Ishizu, M; Unohara, T; Tanaka, K; Shimanoe, C; Nagayoshi, M; Tamura, T; Kubo, Y; Kato, Y; Oze, I; Ito, H; Michihata, N; Nakamura, Y; Tanoue, S; Koriyama, C; Suzuki, S; Nakagawa-Senda, H; Koyama, T; Tomida, S; Kuriki, K; Takashima, N; Harada, A; Wakai, K; Matsuo, K

    CANCER RESEARCH COMMUNICATIONS   4 巻 ( 11 ) 頁: 2986 - 2997   2024年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Cancer Research Communications  

    The present study investigated the relationship between metabolic phenotypes and the risk of cancer in a Japanese population using the criteria of metabolic phenotypes based on an examination and those based on questionnaires. We used data from 25,357 subjects for examination-based analyses and those from 53,042 subjects for questionnaire-based analyses in the Japan Multi-institutional Collaborative Cohort study. Metabolic phenotypes were defined by classifying subjects according to their body mass index (BMI; obesity: BMI ≥25 kg/m2; normal weight: BMI <25 kg/m2) and the number of metabolic abnormalities. Metabolic abnormalities were defined according to metabolic syndrome components of the Joint Interim Statement criteria for examination-based analyses and self-reported histories of diabetes, dyslipidemia, and hypertension for questionnaire-based analyses. Cox proportional hazards regression analyses adjusted for potential confounders were performed for total and site-specific cancer incidence rates according to metabolic phenotypes. Metabolically unhealthy obesity (MUHO) was significantly associated with cancer incidence in both examination-based [HR (95% confidence interval), 1.17 (1.01–1.36)] and questionnaire-based analyses [HR (95% confidence interval), 1.15 (1.04–1.26)]. Regarding site-specific cancer in questionnaire-based analyses, metabolically healthy obesity and MUHO were associated with colorectum and liver cancers in all subjects and with breast cancer in female subjects. Subjects with a metabolically unhealthy normal weight had a higher risk of pancreatic cancer. Moreover, MUHO was associated with corpus uteri cancer in female subjects. This prospective cohort study suggests that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Significance: The prospective cohort study in a large Japanese population suggested that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Moreover, the risk of each site-specific cancer may differ according to metabolic phenotypes.

    DOI: 10.1158/2767-9764.CRC-24-0249

    Open Access

    Web of Science

    Scopus

    PubMed

  5. Food group intakes and high-sensitivity C-reactive protein among community-dwelling Japanese adults: a cross-sectional study 査読有り 国際誌 Open Access

    Matsunaga, T; Wakai, K; Imaeda, N; Goto, C; Tamada, Y; Kato, Y; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Hishida, A; Ikezaki, H; Otonari, J; Takashima, N; Miyagawa, N; Matsuo, K

    PUBLIC HEALTH NUTRITION   27 巻 ( 1 ) 頁: e212   2024年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Public Health Nutrition  

    Objective: Healthy dietary patterns have been linked to lower levels of chronic inflammation. The present study aimed to investigate the associations between food group intakes and high-sensitivity C-reactive protein (hsCRP) among community-dwelling adults. Design: Cross-sectional. Setting: Three areas in Japan (Shiga, Fukuoka, or Kyushu and Okinawa). Participants: The present analysis included 13 648 participants (5126 males and 8522 females; age range, 35-69 years) who had been enrolled in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Food group intakes were estimated using a FFQ. Multiple linear regression was used to examine associations between the quartiles of each energy-adjusted food group intake and log-transformed hsCRP. Results: The following concentration ratios of hsCRP after comparing the highest and lowest quartiles of food group intake were significant: in males, 1.12 (95 % CI 1.02, 1.22) for processed meat, 1.13 (95 % CI 1.03, 1.24) for fish and 0.83 (95 % CI 0.76, 0.90) for nuts; in females, 0.89 (95 % CI 0.81, 0.97) for bread, 1.11 (95 % CI 1.03, 1.19) for processed meat, 0.86 (95 % CI 0.80, 0.92) for vegetables, 1.19 (95 % CI 1.11, 1.29) for fruit, 0.90 (95 % CI 0.84, 0.97) for nuts and 0.88 (95 % CI 0.82, 0.95) for green tea. Conclusions: Processed meat and nut intakes were associated with higher and lower hsCRP levels, respectively, in both sexes. However, for several food groups, including fish and fruit, previous findings from dietary pattern analyses were not supported by the present analyses at the food group level.

    DOI: 10.1017/S1368980024001599

    Open Access

    Web of Science

    Scopus

    PubMed

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講演・口頭発表等 19

  1. The association between meal timing regularity and oral health behavior 国際会議

    Shiomizu S, Mitsui M, Furuie A, Wei H, Tanaka S, Matsuo K, Asaeda M, Nishimura R, Nagayoshi M, Tamura T, Wakai K, Naito M

    The 103rd General Session and Exhibition of the International Association for Dental, Oral, and Craniofacial Research  2025年6月26日 

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    開催年月日: 2025年6月

    記述言語:英語   会議種別:ポスター発表  

    開催地: Barcelona   国名:スペイン  

  2. Association of sleep and dysphagia risk in community-dwelling older adults 国際会議

    Hama Y, Yamada S, Nishimura R, Yoshida M, Tsuga K, Morita E, Tamada Y, Kato Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Naito M

    The 31st annual meeting of Dysphagia Research Society  2023年3月15日 

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    開催年月日: 2023年3月

    記述言語:英語   会議種別:口頭発表(一般)  

    開催地:San Francisco, California, USA   国名:アメリカ合衆国  

  3. Associations between passive smoking exposure level and risk of dysphagia 国際会議

    Maehara T, Nishimura R, Hama Y, Tamura T, Kato Y, Kubo Y, Okada R, Nagayoshi M, Hishida A, Wakai K, Hamajima N, Ohta K, Naito M

    The 100th General Session and Exhibition of the International Association for Dental Research in conjunction with the 5th Meeting of the Asia Pacific Region  2022年6月20日 

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    開催年月日: 2022年6月

    記述言語:英語   会議種別:口頭発表(一般)  

    開催地:Chengdu, Sichuan, China   国名:中華人民共和国  

  4. Relationships between leisure-time exercise and dysphagia risk in the Japanese population 国際会議

    Maehara T, Nishimura R, Wakai K, Tamura T, Nagayoshi M, Kubo Y, Tsukamoto M, Kadomatsu Y, Yoshitake A, Naito M

    The 2nd World Dysphagia Summit 2021 in conjunction with the 26th and 27th Joint Meeting of Japanese Society of Dysphagia Rehabilitation  2021年8月21日 

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    開催年月日: 2021年8月

    記述言語:英語   会議種別:口頭発表(一般)  

    開催地:Nagoya, Japan   国名:日本国  

  5. Weight gain in adulthood and parental hypertension as the risk of hypertension: from the J-MICC Study 国際会議

    Okada R, Naito M, Maruyama K, Tsukamoto M, Sasakabe T, Tamura T, Kawai S, Hishida A, Wakai K, J-MICC Study Group

    The 27th Scientific Meeting of the International Society of Hypertension 

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    開催年月日: 2018年9月

    記述言語:英語   会議種別:口頭発表(一般)  

    開催地:Beijing, China   国名:中華人民共和国  

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その他研究活動 4

  1. J-MICC研究 中央事務局長

    2024年6月
    -
    2025年3月

  2. J-MICC研究 運営委員

    2023年10月
    -
    現在

  3. 大幸研究 研究責任者

    2019年6月
    -
    現在

  4. 薬剤師

    2008年
    -
    現在

科研費 6

  1. 血中脂肪酸分画および脂肪酸摂取量と循環器疾患発症リスク:大規模ゲノムコホート研究

    研究課題/研究課題番号:25K13564  2025年4月 - 2028年3月

    文部科学省 日本学術振興会  科学研究費助成事業  基盤研究(C)

    田村 高志

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    担当区分:研究代表者  資金種別:競争的資金

    配分額:4550000円 ( 直接経費:3500000円 、 間接経費:1050000円 )

  2. ゲノム情報と血中バイオマーカー統合による消化器・肺がんリスクモデルの構築

    研究課題/研究課題番号:23K09646  2023年4月 - 2026年3月

    文部科学省  日本学術振興会 科学研究費補助金  基盤研究(C)

    菱田朝陽, 問山裕二, 川口晃司, 奥川喜永, 永吉真子, 田村高志, 山田宏哉

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    担当区分:研究分担者  資金種別:競争的資金

    わが国のゲノム疫学研究は、国内3大ゲノムコホート研究の進展により、ゲノムワイド関連研究(GWAS)による疾患易罹患性遺伝要因の同定が進み、ポストGWAS時代に突入しており、研究成果の社会実装による還元が求められている。本研究ではポリジェニック・リスクスコアモデル(PRS)等のGWASデータを用いた二次的解析を行うとともに、凍結保存検体を活用したマイクロRNA(miRNA)等の遊離核酸や微量金属元素測定によるがん早期診断能を併せて評価し、両者を統合する統計手法の開発を通じて、これまでに得られたゲノム疫学研究の成果を、がん罹患リスク評価を通じたがん予防という形で社会に還元することを目的とする。

  3. 飲酒と胃がん罹患リスクの関連:飲酒を規定する遺伝要因を考慮した大規模コホート研究

    研究課題/研究課題番号:22K10581  2022年4月 - 2025年3月

    文部科学省  日本学術振興会 科学研究費補助金  基盤研究(C)

    田村高志

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    担当区分:研究代表者  資金種別:競争的資金

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

  4. 栄養素摂取量および食事嗜好性と遺伝要因: ゲノムワイド関連解析による検討

    研究課題/研究課題番号:19K10660  2019年4月 - 2022年3月

    文部科学省  日本学術振興会 科学研究費補助金  基盤研究(C)

    田村高志

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    担当区分:研究代表者  資金種別:競争的資金

    配分額:4290000円 ( 直接経費:3300000円 、 間接経費:990000円 )

  5. 小児における分岐鎖アミノ酸摂取量と糖尿病リスクマーカーに関する研究

    研究課題/研究課題番号:17K15825  2017年4月 - 2019年3月

    文部科学省  日本学術振興会 科学研究費補助金  若手研究(B)

    田村高志

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    担当区分:研究代表者  資金種別:競争的資金

    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

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担当経験のある科目 (本学) 21

  1. 社会医学実習「疾病予防に関するエビデンスの収集と評価」

    2025

  2. 大学院「特徴あるプログラム」東海がん専門医療人材養成プラン(東海がんプロ)次世代がん医療コース:大規模コホート研究データ解析の実際

    2024

  3. 基礎医学体験実習

    2024

  4. 大学院「予防医学総論(疫学総論)」

    2024

  5. 疫学と予防医学:疫学各論ー栄養疫学・公衆栄養

    2024

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