Updated on 2025/06/09

写真a

 
TAMURA Takashi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Associate Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Associate Professor
Contact information
メールアドレス
External link

Degree 1

  1. 博士(医学) ( 2014.3   名古屋大学 ) 

Research Interests 1

  1. コホート研究、症例対照研究、栄養疫学、分子疫学、がん・生活習慣病

Current Research Project and SDGs 3

  1. 分子疫学

  2. 栄養疫学

  3. がん疫学

Research History 6

  1. Nagoya University   Graduate School of Medicine Program in Integrated Medicine Social Life Science   Associate Professor

    2024.5

  2. Nagoya University   Lecturer

    2021.11 - 2024.4

  3. Nagoya University   Designated Assistant Professor

    2020.4 - 2021.11

  4. Nagoya University   Designated Assistant Professor

    2018.10 - 2020.3

  5. Nagoya University   Researcher

    2017.8 - 2018.9

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Education 3

  1. Nagoya University

    2011.4 - 2014.3

  2. Nagoya University

    2009.4 - 2011.3

  3. Hokuriku University

    2004.4 - 2008.3

Professional Memberships 4

  1. 日本疫学会

  2. 日本癌学会

  3. 日本がん疫学・分子疫学研究会

  4. 東海公衆衛生学会

 

Papers 103

  1. Association of Number of Teeth Present With Nutrient Intake and Food Group Consumption Reviewed International journal

    Asaeda, M; Nishimura, R; Suma, S; Tsukamoto, M; Kadomatsu, Y; Kubo, Y; Okada, R; Nagayoshi, M; Tamura, T; Hishida, A; Takeuchi, K; Goto, C; Imaeda, N; Wakai, K; Arimoto, N; Maehara, T; Naito, M

    JOURNAL OF ORAL REHABILITATION     2025.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Oral Rehabilitation  

    Background: Several studies have examined the impact of tooth loss on nutrient intake, yielding mixed results. Objectives: This cross-sectional study aimed to investigate the association among the number of teeth present, nutrient intake and food group consumption in Japanese adults with no history of the four major diseases (diabetes, cancer, heart disease and stroke). Methods: Data were obtained from the baseline survey of the Japan Multi-Institutional Collaborative Cohort study conducted in the Shizuoka and Daiko areas. Participants completed a self-administered questionnaire on their number of teeth, medical history (diabetes, cancer, heart disease and stroke), education level, employment status and lifestyle factors, such as diet, smoking history and exercise habits. The number of teeth was classified into four groups: 0 teeth, 1–19 teeth, 20–27 teeth and 28–32 teeth. Results: A total of 8912 individuals included in the analysis had a mean age ± SD of 51.7 ± 9.5 years, with women accounting for 53.6% of the total. In adult men, the number of teeth was negatively associated with the intake of vitamin D, n-3 highly unsaturated fatty acid intake and seafood, while in women, bread consumption was positively associated with the number of teeth. Conclusions: These findings suggest that the number of teeth is independently associated with poor nutritional status in Japanese adults with no history of the four major diseases.

    DOI: 10.1111/joor.14011

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  2. Manuscript Smoking Behavior-related Genetic Variants and Lung Cancer Risk in Japanese: an Assessment by Mediation Analysis. Reviewed International journal

    Sayaka Yamamoto, Yuriko N Koyanagi, Yuji Iwashita, Tomohiro Shinozaki, Yutaka Fujiwara, Noriaki Sakakura, Megumi Hara, Yuichiro Nishida, Jun Otonari, Hiroaki Ikezaki, Shiroh Tanoue, Chihaya Koriyama, Yumiko Kasugai, Isao Oze, Teruhide Koyama, Satomi Tomida, Nobuaki Michihata, Yohko Nakamura, Sadao Suzuki, Hiroko Nakagawa-Senda, Mako Nagayoshi, Yoko Kubo, Yasufumi Kato, Kenji Wakai, Takeshi Watanabe, Masashi Ishizu, Naoyuki Takashima, Aya Kadota, Yukihide Momozawa, Masahiro Nakatochi, Takashi Tamura, Akio Niimi, Hidemi Ito, Keitaro Matsuo

    Carcinogenesis   Vol. 46 ( 2 )   2025.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    Cigarette smoking is one of the most important risk factors for lung cancer. Genetic studies have shown that smoking behavior-related genetic variants are directly associated with lung cancer, independent of smoking behavior, mainly in European populations. A recent genome-wide association study in Japan identified five loci associated with the number of cigarettes smoked per day. This study aimed to evaluate whether these loci are associated with lung cancer risk directly or indirectly through changing smoking behavior. Here, we conducted a case-control study (1427 cases and 5595 controls) and a prospective cohort study (128 incident cases in 10 520 subjects). Using mediation analysis, we decomposed the total effect of the lead single nucleotide polymorphism (SNP) at each locus on lung cancer risk into direct and indirect effects. The results of the two studies were pooled using a random-effects model to estimate summary relative risks (RRs) and their 95% confidence intervals (CIs). Two studies showed that: (a) rs78277894 (EPHX2-CLU, G>A) had a protective direct effect (RR 0.84; 95% CI 0.77-0.93) on lung cancer risk; and (b) rs56129017 (CYP2A6, C>T) had carcinogenic direct and indirect effects on lung cancer risk (RR 1.26; 95% CI 1.15-1.39 and RR 1.01; 95% CI 1.00-1.01, respectively). This mediation analysis revealed that two smoking behavior-related SNPs, EPHX2-CLU rs78277894 and CYP2A6 rs56129017, were associated with lung cancer risk through pathways independent of changing smoking behavior. Our findings may contribute to our understanding of lung carcinogenesis pathways that cannot be addressed by changes in smoking behavior.

    DOI: 10.1093/carcin/bgaf011

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  3. Dairy Intake and All-Cause, Cancer, and Cardiovascular Disease Mortality Risk in A Large Japanese Population: A 12-Year Follow-Up of the J-MICC Study. Reviewed Open Access

    Naoko Miyagawa, Naoyuki Takashima, Akiko Harada, Aya Kadota, Keiko Kondo, Katsuyuki Miura, Nahomi Imaeda, Chiho Goto, Jun Otonari, Hiroaki Ikezaki, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Takashi Tamura, Yoko Kubo, Yasufumi Kato, Yuriko N Koyanagi, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Rie Ibusuki, Sadao Suzuki, Takeshi Nishiyama, Etsuko Ozaki, Isao Watanabe, Kiyonori Kuriki, Takeshi Watanabe, Masashi Ishizu, Asahi Hishida, Yoshikuni Kita, Kenji Wakai, Keitaro Matsuo

    Journal of atherosclerosis and thrombosis   Vol. 32 ( 5 ) page: 596 - 607   2025

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Japan Atherosclerosis Society  

    AIM: We examined the association between dairy intake and all-cause, cancer, and cardiovascular disease mortality in a cohort of the general population followed up for 12 years across Japan. METHODS: We conducted a longitudinal cohort study of 79,715 participants from the Japan Multi-Institutional Collaborative Cohort study (57.2% women, mean age 54.7 years old). The amount of dairy (milk and yogurt) intake was determined using a validated short-food frequency questionnaire. The hazard ratio for mortality according to sex-specific tertile of dairy intake was calculated using Cox proportional hazards regression models with adjustment for potential confounding factors and dietary factors by sex. RESULTS: During the follow-up period (932,738 person-years), 3,723 participants died, including 2,088 cancer and 530 cardiovascular disease deaths. The highest tertile of total dairy intake (versus the lowest tertile) was associated with a 19% lower all-cause mortality risk (hazard ratio=0.81, 95% confidence interval: 0.70-0.92; P for trend=0.001) in women. Similarly, we observed inverse associations between milk intake and all-cause and cancer mortality risk in women, yogurt intake and cardiovascular disease risk in women, and yogurt intake and all-cause mortality risk in both sexes. CONCLUSION: A higher total dairy and milk intakes in women and yogurt intake in both sexes were associated with a reduced risk of all-cause mortality in the general population across Japan during the 12-year follow-up period.

    DOI: 10.5551/jat.65049

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    CiNii Research

  4. The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Reviewed International journal Open Access

    Takeshi Watanabe, Tien Van Nguyen, Sakurako Katsuura-Kamano, Kokichi Arisawa, Masashi Ishizu, Taichi Unohara, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Takashi Tamura, Yoko Kubo, Yasufumi Kato, Isao Oze, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Chihaya Koriyama, Sadao Suzuki, Hiroko Nakagawa-Senda, Teruhide Koyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Akiko Harada, Kenji Wakai, Keitaro Matsuo

    Cancer research communications   Vol. 4 ( 11 ) page: 2986 - 2997   2024.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    The present study investigated the relationship between metabolic phenotypes and the risk of cancer in a Japanese population using the criteria of metabolic phenotypes based on an examination and those based on questionnaires. We used data from 25,357 subjects for examination-based analyses and those from 53,042 subjects for questionnaire-based analyses in the Japan Multi-Institutional Collaborative Cohort Study. Metabolic phenotypes were defined by classifying subjects according to their BMI (obesity: BMI ≥25 kg/m2; normal weight: BMI <25 kg/m2) and the number of metabolic abnormalities. Metabolic abnormalities were defined according to metabolic syndrome components of the Joint Interim Statement Criteria for examination-based analyses and self-reported histories of diabetes, dyslipidemia, and hypertension for questionnaire-based analyses. Cox proportional hazards regression analyses adjusted for potential confounders were performed for total and site-specific cancer incidence according to metabolic phenotypes. Metabolically unhealthy obesity (MUHO) was significantly associated with cancer incidence in both examination-based [HR (95% CI): 1.17 (1.01-1.36)] and questionnaire-based analyses [HR (95% CI): 1.15 (1.04-1.26)]. Regarding site-specific cancer in questionnaire-based analyses, metabolically healthy obesity and MUHO were associated with colorectum and liver cancers in all subjects and with breast cancer in female subjects. Subjects with a metabolically unhealthy normal weight had a higher risk of pancreatic cancer. Moreover, MUHO was associated with corpus uteri cancer in female subjects. This prospective cohort study suggests that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults.

    DOI: 10.1158/2767-9764.CRC-24-0249

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  5. Food group intakes and high-sensitivity C-reactive protein among community-dwelling Japanese adults: a cross-sectional study. Reviewed International journal Open Access

    Takashi Matsunaga, Kenji Wakai, Nahomi Imaeda, Chiho Goto, Yudai Tamada, Yasufumi Kato, Yoko Kubo, Rieko Okada, Mako Nagayoshi, Takashi Tamura, Asahi Hishida, Hiroaki Ikezaki, Jun Otonari, Naoyuki Takashima, Naoko Miyagawa, Keitaro Matsuo

    Public health nutrition   Vol. 27 ( 1 ) page: e212   2024.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: Healthy dietary patterns have been linked to lower levels of chronic inflammation. The present study aimed to investigate the associations between food group intakes and high-sensitivity C-reactive protein (hsCRP) among community-dwelling adults. DESIGN: Cross-sectional. SETTING: Three areas in Japan (Shiga, Fukuoka, or Kyushu and Okinawa). PARTICIPANTS: The present analysis included 13 648 participants (5126 males and 8522 females; age range, 35-69 years) who had been enrolled in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Food group intakes were estimated using a FFQ. Multiple linear regression was used to examine associations between the quartiles of each energy-adjusted food group intake and log-transformed hsCRP. RESULTS: The following concentration ratios of hsCRP after comparing the highest and lowest quartiles of food group intake were significant: in males, 1·12 (95 % CI 1·02, 1·22) for processed meat, 1·13 (95 % CI 1·03, 1·24) for fish and 0·83 (95 % CI 0·76, 0·90) for nuts; in females, 0·89 (95 % CI 0·81, 0·97) for bread, 1·11 (95 % CI 1·03, 1·19) for processed meat, 0·86 (95 % CI 0·80, 0·92) for vegetables, 1·19 (95 % CI 1·11, 1·29) for fruit, 0·90 (95 % CI 0·84, 0·97) for nuts and 0·88 (95 % CI 0·82, 0·95) for green tea. CONCLUSIONS: Processed meat and nut intakes were associated with higher and lower hsCRP levels, respectively, in both sexes. However, for several food groups, including fish and fruit, previous findings from dietary pattern analyses were not supported by the present analyses at the food group level.

    DOI: 10.1017/S1368980024001599

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Presentations 19

  1. The association between meal timing regularity and oral health behavior International conference

    Shiomizu S, Mitsui M, Furuie A, Wei H, Tanaka S, Matsuo K, Asaeda M, Nishimura R, Nagayoshi M, Tamura T, Wakai K, Naito M

    The 103rd General Session and Exhibition of the International Association for Dental, Oral, and Craniofacial Research  2025.6.26 

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    Event date: 2025.6

    Language:English   Presentation type:Poster presentation  

    Venue: Barcelona   Country:Spain  

  2. Association of sleep and dysphagia risk in community-dwelling older adults International conference

    Hama Y, Yamada S, Nishimura R, Yoshida M, Tsuga K, Morita E, Tamada Y, Kato Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Naito M

    The 31st annual meeting of Dysphagia Research Society  2023.3.15 

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    Event date: 2023.3

    Language:English   Presentation type:Oral presentation (general)  

    Venue:San Francisco, California, USA   Country:United States  

  3. Associations between passive smoking exposure level and risk of dysphagia International conference

    Maehara T, Nishimura R, Hama Y, Tamura T, Kato Y, Kubo Y, Okada R, Nagayoshi M, Hishida A, Wakai K, Hamajima N, Ohta K, Naito M

    The 100th General Session and Exhibition of the International Association for Dental Research in conjunction with the 5th Meeting of the Asia Pacific Region  2022.6.20 

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    Event date: 2022.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Chengdu, Sichuan, China   Country:China  

  4. Relationships between leisure-time exercise and dysphagia risk in the Japanese population International conference

    Maehara T, Nishimura R, Wakai K, Tamura T, Nagayoshi M, Kubo Y, Tsukamoto M, Kadomatsu Y, Yoshitake A, Naito M

    The 2nd World Dysphagia Summit 2021 in conjunction with the 26th and 27th Joint Meeting of Japanese Society of Dysphagia Rehabilitation  2021.8.21 

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    Event date: 2021.8

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Nagoya, Japan   Country:Japan  

  5. Weight gain in adulthood and parental hypertension as the risk of hypertension: from the J-MICC Study International conference

    Okada R, Naito M, Maruyama K, Tsukamoto M, Sasakabe T, Tamura T, Kawai S, Hishida A, Wakai K, J-MICC Study Group

    The 27th Scientific Meeting of the International Society of Hypertension 

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    Event date: 2018.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Beijing, China   Country:China  

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Other research activities 4

  1. J-MICC研究 中央事務局長

    2024.6
    -
    2025.3

  2. J-MICC研究 運営委員

    2023.10

  3. 大幸研究 研究責任者

    2019.6

  4. 薬剤師

    2008

KAKENHI (Grants-in-Aid for Scientific Research) 6

  1. 血中脂肪酸分画および脂肪酸摂取量と循環器疾患発症リスク:大規模ゲノムコホート研究

    Grant number:25K13564  2025.4 - 2028.3

    文部科学省 日本学術振興会  科学研究費助成事業  基盤研究(C)

    田村 高志

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

  2. Construction of integrated risk model for gastrointestinal and lung cancers based on genomic information and blood biomarkers

    Grant number:23K09646  2023.4 - 2026.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s)  Grant type:Competitive

  3. 飲酒と胃がん罹患リスクの関連:飲酒を規定する遺伝要因を考慮した大規模コホート研究

    Grant number:22K10581  2022.4 - 2025.3

    文部科学省  日本学術振興会 科学研究費補助金  基盤研究(C)

    田村高志

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

  4. 栄養素摂取量および食事嗜好性と遺伝要因: ゲノムワイド関連解析による検討

    Grant number:19K10660  2019.4 - 2022.3

    文部科学省  日本学術振興会 科学研究費補助金  基盤研究(C)

    田村高志

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  5. 小児における分岐鎖アミノ酸摂取量と糖尿病リスクマーカーに関する研究

    Grant number:17K15825  2017.4 - 2019.3

    文部科学省  日本学術振興会 科学研究費補助金  若手研究(B)

    田村高志

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

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Teaching Experience (On-campus) 21

  1. 社会医学実習「疾病予防に関するエビデンスの収集と評価」

    2025

  2. 大学院「特徴あるプログラム」東海がん専門医療人材養成プラン(東海がんプロ)次世代がん医療コース:大規模コホート研究データ解析の実際

    2024

  3. 基礎医学体験実習

    2024

  4. 大学院「予防医学総論(疫学総論)」

    2024

  5. 疫学と予防医学:疫学各論ー栄養疫学・公衆栄養

    2024

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