Faculty Profiles - TAKEGAMI Yasuhiko

Papers - TAKEGAMI Yasuhiko

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Arterial embolism due to massive cement leakage during total hip arthroplasty revision. Reviewed Open Access

Yusuke Kazama, Yasuhiko Takegami, Yusuke Osawa, Kazuya Makida, Taisuke Seki

Nagoya journal of medical science Vol. 83 ( 2 ) page： 353 - 359 2021.5

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

Total hip arthroplasty with cementing techniques leads to good clinical outcomes, but critical vascular complications can sometimes occur due to cement leakage into the pelvis. In this report, we describe a case of massive cement leakage that caused an arterial embolism. When exfoliating cement from an artery, the surgeon should note not only direct injury to the vessels but also the potential for arterial embolism.

DOI： 10.18999/nagjms.83.2.353

"いつの間にか骨折"をAI(人工知能)で胸部単純X線写真から診断する、陳旧性椎体骨折検出システムの開発研究多施設共同研究

佐藤洋一, 朝本学宗, 本田聖和, 鈴木朋浩, 三嶋真爾, 伊藤孝紀, 竹上靖彦

日本骨粗鬆症学会雑誌 Vol. 7 ( 2 ) page： 300 - 303 2021.5

Authorship：Last author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(一社)日本骨粗鬆症学会

一般に検診などで撮影頻度が高い胸部単純X線写真が撮影範囲に椎体骨折の好発部位である胸椎〜第2腰椎までを含むことに着目し、骨粗鬆症のスクリーニングに利活用する可能性について検討した。そしてこの診断時に、人工知能(AI)を用いて胸部単純X線写真における既存椎体骨折を検知する画像診断システムの開発を行った。胸部単純X線写真かつ胸椎〜腰椎レベルを含むCTまたはMRIを撮影した65歳以上の患者1889例(男性558例、女性1331例、平均77.4歳)を対象とした。内部データセットにおける機械精度では、蒲郡市民病院から得られたデータセットにより訓練された学習モデルのテスト画像に対する機械精度は診断精度92.1%、閾値0.69としたときの感度が95.8%、特異度が93.0%であった。また、外部データセットにおける機械精度では、蒲郡市民病院から得られたデータセットにより訓練された学習モデルの津島市民病院およびJCHO東京新宿メディカルセンターから得られたテスト画像に対する機械精度は診断精度71.3%であり、ROC曲線から算出されたAUCは0.78となった。既存椎体骨折をAIが検知する画像診断システムは、既存椎体骨折を有する骨粗鬆症患者のスクリーニングに有用な可能性があると考えられた。

J-GLOBAL

Association between Low Muscle Mass and Inflammatory Cytokines. Reviewed International journal Open Access

Sadayuki Ito, Hiroaki Nakashima, Kei Ando, Kazuyoshi Kobayashi, Masaaki Machino, Taisuke Seki, Shinya Ishizuka, Ryosuke Fujii, Yasuhiko Takegami, Hiroya Yamada, Yoshitaka Ando, Koji Suzuki, Yukiharu Hasegawa, Shiro Imagama

BioMed research international Vol. 2021 page： 5572742 - 5572742 2021.4

Language：English Publishing type：Research paper (scientific journal)

Sarcopenia is a multifaceted geriatric syndrome associated with the loss of muscle mass. We examined the relationship between low muscle mass and inflammatory cytokines in the context of aging. This study involved 299 participants (127 men and 172 women; mean age 63.3 ± 9.8 years) who underwent health checkups for body composition and inflammatory cytokine (TNF-alpha, IL-6, and MCP-1) levels. Muscle mass was determined using the skeletal muscle mass index. We divided the participants into the normal (N) and low muscle mass (L) groups and compared the levels of inflammatory cytokines in nonelderly (<65 years) and elderly (≥65 years) participants. Among the nonelderly subjects, C-reactive protein was significantly lower in the L group than in the N group (p < 0.05). However, there was no significant difference in the inflammatory cytokine levels between the groups. Among the elderly subjects, the TNF-alpha level was significantly lower in the L group than in the N group (p < 0.05), whereas there were no significant differences in the IL-6 and MCP-1 levels. Moreover, TNF-alpha was identified as a risk factor for the L group in the logistic regression analysis (Exp (B) 0.935, 95% CI: 0.876-0.997, p = 0.04). Although a low TNF-alpha level is a risk factor for low muscle mass, inflammatory cytokine levels are not necessarily elevated in elderly individuals with the loss of muscle mass.

DOI： 10.1155/2021/5572742

Bioelectrical Impedance Analysis and Manual Measurements of Neck Circumference Are Interchangeable, and Declining Neck Circumference Is Related to Presarcopenia. Reviewed International journal Open Access

Masaaki Machino, Kei Ando, Kazuyoshi Kobayashi, Hiroaki Nakashima, Satoshi Tanaka, Shunsuke Kanbara, Sadayuki Ito, Taro Inoue, Hiroyuki Koshimizu, Taisuke Seki, Shinya Ishizuka, Yasuhiko Takegami, Yukiharu Hasegawa, Shiro Imagama

BioMed research international Vol. 2021 page： 6622398 - 6622398 2021.3

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Preventive medicine is important in an aging society. Presarcopenia is the preliminary stage of sarcopenia. Recent advances in bioelectrical impedance analysis (BIA) devices have enabled automatic estimation of neck circumference (NC). However, the agreement between and interchangeability of NC measured manually and that calculated with BIA have not been evaluated. We performed these analyses in the context of health checkups and investigated their associations with presarcopenia. METHODS: We enrolled 318 participants who underwent anthropometric measurements, including NC measured manually and by BIA; assessment of physical function; and blood testing. We used Bland-Altman analysis to calculate the agreement between and interchangeability of NC measurements by BIA and by the manual method. We then statistically compared normal participants and those with presarcopenia. Using multivariable analysis, we subsequently investigated significant risk factors for presarcopenia. We defined presarcopenia according to the appendicular skeletal muscle index (aSMI; the ratio of arm and leg skeletal muscle mass to height2). RESULTS: Bland-Altman analysis showed that bias (BIA-manual) was negative overall (-1.07), for male participants (-1.23), and for female participants (-0.96). This finding suggests that BIA measurement is an underestimate in comparison with manual measurement. NC measurement by BIA was found to be interchangeable with that by manual methods, inasmuch as the percentage error was less than 5% overall (4.38%), for male participants (3.81%), and for female participants (4.58%). Univariable analysis revealed that NC was significantly smaller in the participants with presarcopenia than in those without. Multivariable analysis, adjusted for confounding factors, revealed that a decrease in NC was significantly correlated with presarcopenia. CONCLUSIONS: BIA measurements of NC are interchangeable within about 95% with manual measurements. The decrease in NC measured by BIA was significantly associated with presarcopenia in both genders. NC measurement can be used for early detection of presarcopenia.

DOI： 10.1155/2021/6622398

高齢者の脆弱性骨盤骨折(不安定型)の保存治療の検討

大道俊文, 竹上靖彦, 徳武克浩, 斉藤祐樹, 今釜史郎

中部日本整形外科災害外科学会雑誌 Vol. 64 ( 春季学会 ) page： 145 - 145 2021.3

脆弱性骨盤骨折不安定型における手術加療と保存加療での臨床成績の比較

斉藤祐樹, 竹上靖彦, 徳武克浩, 大道俊文, 今釜史郎

中部日本整形外科災害外科学会雑誌 Vol. 64 ( 春季学会 ) page： 145 - 145 2021.3

踵骨骨折手術においてBohler角を整復・維持することは重要である

杉本遼介, 竹上靖彦, 鏡味佑志朗, 杉本拓也, 徳武克浩, 今釜史郎

中部日本整形外科災害外科学会雑誌 Vol. 64 ( 春季学会 ) page： 106 - 106 2021.3

踵骨骨折術後の免荷装具は有効か?-多施設共同後ろ向き研究-

鏡味佑志朗, 竹上靖彦, 徳武克浩, 杉本拓也, 杉本遼介, 今釜史郎

中部日本整形外科災害外科学会雑誌 Vol. 64 ( 春季学会 ) page： 106 - 106 2021.3

鎖骨遠位端骨折に対する固定材料による臨床成績の比較多施設共同後向き研究

高橋博司, 竹上靖彦, 片山雄二郎, 徳武克浩, 今釜史郎

中部日本整形外科災害外科学会雑誌 Vol. 64 ( 春季学会 ) page： 140 - 140 2021.3

Pelvic Tilt Reduces the Accuracy of Acetabular Component Placement When Using a Portable Navigation System: An In Vitro Study. Reviewed International journal Open Access

Hiroshi Asai, Yasuhiko Takegami, Taisuke Seki, Naoki Ishiguro

Arthroplasty today Vol. 7 page： 177 - 181 2021.2

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier {BV}

BACKGROUND: A portable navigation system (PNS) was recently introduced. The PNS enables surgeons to place the acetabular component accurately. While the margin of the error for the cup abduction and anteversion was larger than the values obtained from a computed tomography-based navigation system. We hypothesized that the accuracy of the PNS might be affected by pelvic tilt. MATERIAL AND METHODS: A bone substitute model of the pelvis was used in this in vitro study. We set the acetabular component using PNS. We set the acetabular component angle after changing the sagittal, coronal, and axial pelvic tilt. We calculated the difference between the angle displayed on the PNS display and the actual angle of the acetabular component. The difference in inclination angle was defined as ΔRI, and the difference in the anteversion angle was defined as ΔRA. We evaluated the trends in this ΔRI and ΔRA due to the pelvic tilt. RESULTS: In this in vitro study, the placement of the acetabular component was accurate in the neutral position; ΔRI was 0.5 ± 0.7° and ΔRA was 1.0 ± 0.7°. Sagittal pelvic tilt and axial pelvic tilt increased both the ΔRA and ΔRI (P = .017). Coronal tilt increased ΔRI but did not change ΔRA. CONCLUSIONS: While the PNS may enable surgeons to place accurate component placement in the neutral position, its accuracy decreased by pelvic tilt. The surgeons should use a solid pelvic lateral positioner for reducing discrepancies in pelvic tilt when using the PNS in the lateral decubitus position.

DOI： 10.1016/j.artd.2020.12.012

Does unilateral total hip arthroplasty improve pain and function in the non-operative hip joint? Reviewed International journal

Yasuhiko Takegami, Taisuke Seki, Yusuke Osawa, Taiki Kusano, Kazuya Makida, Naoki Ishiguro

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie Vol. 30 ( 8 ) page： 1411 - 1416 2020.12

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media {LLC}

BACKGROUND: Some reports suggested that the status of the opposite-side hip affects clinical outcomes of unilateral total hip arthroplasty (THA) for hip osteoarthritis (HOA). This study aimed to determine whether unilateral THA could improve pain and movement of the non-operative hip. METHODS: The analysis included 195 patients divided into three groups according to contralateral hip status based on radiographic change assessed by Kellgren-Lawrence (KL) grade: normal hip (Group N: n = 124), HOA with KL grade > 2 (Group O: n = 39), and THA patients who already underwent THA in their opposite hip joint (Group T: n = 32). All patients were interviewed and examined preoperatively and at 1-year intervals after surgery. Hip function was evaluated with Harris Hip Score (HHS) and range of motion (ROM) preoperatively and at 1-year follow-up. We used the Japanese Orthopedic Association Hip-Disease Evaluation Questionnaire (JHEQ) and the Visual Analogue Scale (VAS) for separately evaluated right and left hip joints. RESULTS: The mJHEQ movement, which indicated the activity, and flexion of ROM in the non-operative hip improved in group N and group T. The VAS and JHEQ pain values did not differ between preoperative and 1-year follow-up in all groups. In the operative side, HHS function, JHEQ movement values in group O were significantly lower than those of groups N and T at 1-year follow-up. CONCLUSION: Unilateral THA may improve non-operative hip movement and active daily life except when the non-operated hip shows osteoarthritis. It did not improve non-operative hip pain, regardless of the condition on the other side. Clinical outcomes of unilateral THA may be affected by opposite hip status each other.

DOI： 10.1007/s00590-020-02716-0

Web of Science

Scopus

PubMed

Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia. Reviewed International journal Open Access

Shinya Kaneko, Masaki Matsushita, Kenichi Mishima, Yasuhiko Takegami, Shiro Imagama, Hiroshi Kitoh

Bone reports Vol. 13 ( 3 ) page： 100708 - 100708 2020.12

Language：English Publishing type：Research paper (scientific journal)

Achondroplasia (ACH) is the most common form of short-limbed skeletal dysplasia. Patients with ACH sometimes undergo lower limb lengthening to get functional and psychological achievements. The periosteal resection (PR) is a known mechanism to increase longitudinal bone growth without osteotomy, although the results are not predictable. It could be alternative for limb lengthening in a minimally invasive technique. The purpose of this study is to evaluate the effect of PR on acceleration of bone growth in a mouse model of ACH (Fgfr3 ach). We performed a circumferential resection of periosteum on the proximal tibia to both wild-type and Fgfr3 ach mice at the age of four weeks. The second PR was done one week later in each mouse, which was subsequently sacrificed at the age of six weeks for micro-computed tomography (micro-CT) scan and histological examinations. We measured tibial bone length, bone volume, and metaphyseal trabecular bone parameters, including bone volume/tissue volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N) by reconstructed micro-CT images. We also quantified the entire width of the growth plate of the proximal tibial from the sections stained with hematoxylin and eosin. Tibial bone length and bone volume of the PR side were significantly larger than the sham side in wild-type mice, while they were not statistically significant in Fgfr3 ach mice. The BV/TV and Tb.N in the metaphysis were significantly decreased in the PR side of both mice. The histological analysis revealed that the growth plate of the proximal tibia was significantly wider in the PR side of wild-type mice while it showed no difference in width between the PR side and the sham side in Fgfr3 ach mice. PR promoted longitudinal bone growth in wild-type mice, but it exhibited only a marginal effect on bone growth in Fgfr3 ach mice.

DOI： 10.1016/j.bonr.2020.100708

Influence of Global Spine Sagittal Balance and Spinal Degenerative Changes on Locomotive Syndrome Risk in a Middle-Age and Elderly Community-Living Population. Reviewed International journal Open Access

Masaaki Machino, Kei Ando, Kazuyoshi Kobayashi, Hiroaki Nakashima, Shunsuke Kanbara, Sadayuki Ito, Taro Inoue, Hidetoshi Yamaguchi, Hiroyuki Koshimizu, Taisuke Seki, Shinya Ishizuka, Yasuhiko Takegami, Naoki Ishiguro, Yukiharu Hasegawa, Shiro Imagama

BioMed research international Vol. 2020 page： 3274864 - 3274864 2020.9

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The aim of this study was to describe the characteristics of each locomotive syndrome (LS) risk stage, including global spine sagittal alignment, spinal degenerative changes evident on plain radiographs, low back pain (LBP), muscle strength, and physical ability in middle-aged and elderly people in a health checkup. METHODS: This study included 211 healthy Japanese volunteers (89 men and 122 women; mean age, 64.0 years) who underwent assessment with both radiographs and Spinal Mouse. Spinal sagittal parameters included thoracic kyphosis angle (TKA), lumbar lordosis angle (LLA), sagittal vertical axis, and spinal inclination angle (SIA). Lumbar disc height (LDH) and lumbar osteophyte formation (LOF) at each level were evaluated as the spinal degenerative changes. The LS assessment comprised three tests: stand-up test, two-step test, and 25-question Geriatric Locomotive Function Scale (GLFS-25). The subjects were divided into three groups (no risk, stage 1 LS, or stage 2 LS) according to LS risk test criteria. The prevalence of LBP was investigated with a visual analogue scale (VAS), and physical performances were also compared among the groups. RESULTS: Of the participants, 122 had no risk of LS, 56 had stage 1 LS risk, and 29 had stage 2 LS risk. With increasing LS risk stage, the prevalence of and VAS score for LBP increased significantly, and back muscle strength and physical abilities decreased significantly. The TKA did not differ among the three groups. The LLA decreased gradually with LS risk stage (P = 0.0001). At each level except L1-L2 and L5-S1, LDH decreased gradually with LS risk stage. The prevalence of LOF increased significantly with increasing LS risk stage. The SIA increased significantly with LS risk stage (P = 0.0167). CONCLUSIONS: Participants with LS had higher prevalence of spinal degeneration, small LLA, and global spinal imbalance by anterior spinal inclination.

DOI： 10.1155/2020/3274864

Associations of Serum MicroRNA with Bone Mineral Density in Community-Dwelling Subjects: The Yakumo Study. Reviewed International journal Open Access

Hiroaki Nakashima, Kei Ando, Kazuyoshi Kobayashi, Taisuke Seki, Shinya Ishizuka, Ryosuke Fujii, Yasuhiko Takegami, Hiroya Yamada, Yoshitaka Ando, Koji Suzuki, Yukiharu Hasegawa, Shiro Imagama

BioMed research international Vol. 2020 page： 5047243 - 5047243 2020.7

Language：English Publishing type：Research paper (scientific journal)

Osteoporosis is a disease characterized by deterioration of bone tissue and mass, with an increasing global prevalence. Therefore, the discovery of biomarkers for osteoporosis would help to guide appropriate treatment. Circulating microRNAs (miRNAs) have become increasingly recognized as biomarkers for detecting diseases. However, few studies have investigated the association of circulating miRNA with osteoporosis in the general population. The aim of this study was to identify miRNA associated with osteoporosis in a general resident health check-up for potential use as an osteoporosis biomarker. We conducted a cross-sectional study as part of a health check-up program and recruited 352 volunteers (139 men, 213 women, mean age 64.1 ± 9.6 years). Osteoporosis was diagnosed according to the WHO classification. Twenty-two candidate microRNAs were screened through real-time quantitative PCR, and miRNAs associated with osteoporosis were analyzed using logistic regression analysis including other risk factors. In total, 95 females and 30 males were diagnosed with osteoporosis with bone mineral density tests (BMD: T-score < -2.5). We found that miR195 was significantly lower in females, while miR150 and miR222 were significantly higher in males. The results of the logistic regression analysis indicated that in females, higher age and lower miR195 (odds ratio: 0.45, 95% confidential interval: 0.03-0.98) were significant risk factors for lower BMD, while the presence of a smoking habit and lower miR150 (odds ratio: 1.35, 95% confidential interval: 1.02-1.79) were significant risk factors for osteoporosis. Serum levels of miR195 and miR150 are independently associated with low bone mineral density in females and males, respectively.

DOI： 10.1155/2020/5047243

The relationship between radiographic findings and patient-reported outcomes in adult hip dysplasia patients: A hospital cross-sectional study. Reviewed

Yasuhiko Takegami, Taisuke Seki, Yusuke Osawa, Taiki Kusano, Naoki Ishiguro

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association Vol. 25 ( 4 ) page： 606 - 611 2020.7

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier {BV}

INTRODUCTION: This study aimed to clarify the relationship of individual radiographic parameters and features with the patient-reported outcome measurements (PROMs) of patients with developmental dysplasia of the hip (DDH) in a hospital-referred cross-sectional analysis. METHODS: This cross-sectional study included 108 Japanese DDH patients (female, n = 88; male, n = 20; mean age, 43.4 years). We recorded the CE angle, angle of Sharp, ARO, ADR, AHI, crossover sign, pistol grip deformity, and femoral head-neck ratio, which were measured on the AP view, and the α-angle, which was measured on the Lauenstein view. We also recorded cyst formation and osteophytes on either view. We used the Japanese Orthopaedic Association hip disease evaluation questionnaire (JHEQ) to assess the PROMs. The PROMs of patients with and without cysts or osteophytes and those of patients with or without cam or pincer deformity were compared. The relationships between specific PROMs and radiographic features were evaluated with a linear regression analysis and independent associations between PROMs and radiographic features were assessed with a multiple regression analysis using various independent variables. RESULTS: The JHEQ movement and mental values in patients with cyst formation were significantly lower in comparison to those in patients without cyst formation. The JHEQ subscale values did not differ according to the presence or absence of osteophytes, cam deformity or pincer deformity. The CE angle was found to be associated with the JHEQ movement score in the linear regression analysis. To identify radiographic features that were independently associated with each of the JHEQ subscale scores, we performed a multiple regression analysis with age, body mass index, sex and the number of affected hip joints (bilateral or unilateral) included as independent variables. The CE angle was found to be independently associated with JHEQ movement. CONCLUSION: The CE angle was independently associated with the JHEQ movement value.

DOI： 10.1016/j.jos.2019.09.007

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Scopus

PubMed

Curved Intertrochanteric Varus Osteotomy vs Total Hip Arthroplasty for Osteonecrosis of the Femoral Head in Patients Under 50 Years Old. Reviewed International journal Open Access

Yusuke Osawa, Taisuke Seki, Toshiaki Okura, Yasuhiko Takegami, Naoki Ishiguro, Yukiharu Hasegawa

The Journal of arthroplasty Vol. 35 ( 6 ) page： 1600 - 1605 2020.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Given recent advances in total hip arthroplasty (THA), curved intertrochanteric varus osteotomy (CVO) is not indicated as a treatment for osteonecrosis of the femoral head (ONFH), unless indicated to maintain long-term hip function and achieve patient satisfaction. We aimed to compare the clinical outcomes of CVO with those of THA for treatment of ONFH in young adults <50 years old. METHODS: This comparative study included 105 ONFH patients: 59 patients (65 hips) who underwent CVO and 46 patients (56 hips) who underwent THA. Assessment tools included the Harris hip score (HHS), patient-reported outcomes of the Short Form-36, Oxford hip score, Japanese Orthopaedic Association Hip-Disease Evaluation Questionnaire, and University of California, Los Angeles score, together with complication and survival rates. RESULTS: Preoperative HHS was significantly higher in the CVO group than in the THA group (P < .01). At the last follow-up, no between-group differences were noted in HHS, all domains of Japanese Orthopaedic Association Hip-Disease Evaluation Questionnaire scores, Oxford hip score, and Short Form-36. University of California, Los Angeles scores and complication rates were comparable: 3% for the CVO and 7% for the THA group. The 10-year survival rate with surgery for any reason as the end point was comparable, at 91.8% for the CVO and 97.7% for the THA group. CONCLUSION: Functional outcomes, survival rate, and sporting activities for patients <50 years old undergoing CVO or THA for ONFH were comparable after a mean follow-up period of 10 years. Strict indications for CVO can help maintain hip function and patient satisfaction equivalent to that for THA, in the long term.

DOI： 10.1016/j.arth.2020.01.026

Surgery trends for osteonecrosis of the femoral head: a fifteen-year multi-centre study in Japan. Reviewed International journal Open Access

Shinya Kaneko, Yasuhiko Takegami, Taisuke Seki, Wakaba Fukushima, Takashi Sakai, Wataru Ando, Naoki Ishiguro, Nobuhiko Sugano

International orthopaedics Vol. 44 ( 4 ) page： 761 - 769 2020.4

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The most appropriate procedure and at what type and stage of osteonecrosis of the femoral head (ONFH) these procedures had been argued. We attempted to clarify the trend in surgical operations with respect to the age of patients, type classification, and stage of ONFH over a period of 15 years by using the multi-center sentinel monitoring system in Japan. METHODS: We evaluated the hips of 3844 patients using this system in three phases of every five years from 2003 to 2017. We classified the surgical procedures as osteotomy (OT), hemiarthroplasty (Hemi), and total hip arthroplasty (THA). We assessed the trend in age, type classification, and stage of ONFH over three time periods; "early," and the "late." We calculated the proportion of surgeries for ONFH in each period. We used the Cochran-Armitage test to evaluate trends in proportion of two levels of characteristics across three time periods. RESULTS: The proportion of younger patients significantly decreased. The proportion of OT and Hemi decreased over time, while the proportion of THA increased. The proportion of patients with types C1 and C2 who underwent OT and Hemi decreased over time. In contrast, that of THA increased. The proportion of patients who underwent OT and Hemi significantly decreased; the proportion of patients who underwent THA significantly increased over time at all stages. CONCLUSIONS: In Japan, the younger patients underwent surgery for ONFH decreased. The patients who underwent OT and Hemi for ONFH decreased, while that of THA increased over time.

DOI： 10.1007/s00264-020-04480-6

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Scopus

PubMed

Measurement of equivalence between the web and paper versions of the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire. Reviewed International journal Open Access

Yasuhiko Takegami, Taisuke Seki, Yoshitoshi Higuchi, Yusuke Osawa, Naoki Ishiguro

Modern rheumatology Vol. 30 ( 2 ) page： 397 - 401 2020.3

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

Objectives: Digitised patient-reported outcome may be beneficial for physicians and patients. The Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) can only be completed with paper and pencil (pJHEQ). We newly developed a web version of the JHEQ (wJHEQ). This study aimed to determine whether the scores obtained with the wJHEQ are equivalent to those from the pJHEQ, how much the wJHEQ would decrease missing answers, and which JHEQ the participants preferred to use.Methods: To measure equivalence between the pJHEQ and wJHEQ, we evaluated the mean score difference for each subscale (pain, movement, mental) and Visual Analogue Scale (VAS; satisfaction, right hip pain, left hip pain) and then assessed the intraclass correlation coefficients (ICC) between the two scores. ICC values ≥0.75 were defined as excellent agreement. We used Bland-Altman analysis to assess level of agreement between the values of the two questionnaires. We compared the number of incomplete forms and amount of missing data between the two questionnaires. We investigated ease of use by asking the participants which format was easier to use.Results: This study comprised 113 patients (mean age 58.1 years, 81% female) with hip disease. Mean score differences for each subscale between the wJHEQ and pJHEQ were not significantly different. The values of ICC for each subscale and each VAS were all >0.75. All 113 participants completed the wJHEQ questionnaire, whereas nine patients did not complete the pJHEQ form. There was a significant statistical difference between the completion rate of the wJHEQ and that of the pJHEQ (p = .0017). Fifty-seven participants (55%) preferred the wJHEQ, whereas 33 participants (32%) preferred the pJHEQ.Conclusion: The wJHEQ was found to be equivalent to the original pJHEQ. The wJHEQ significantly decreased the numbers of missing answers and incomplete forms. The participants felt ease of use was nearly equivalent. The wJHEQ might help facilitate more complete assessments in clinical trials and research.

DOI： 10.1080/14397595.2019.1592799

ロコモティブシンドロームにおけるエピジェネティックな異常の解析 Yakumo study

竹上靖彦, 関泰輔, 大澤郁介, 草野大樹, 牧田和也, 鈴木康司, 今釜史郎, 石黒直樹, 長谷川幸治

日本整形外科学会雑誌 Vol. 94 ( 2 ) page： S137 - S137 2020.3

Author Correction: Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis. Reviewed International journal Open Access

Toshiaki Okura, Bisei Ohkawara, Yasuhiko Takegami, Mikako Ito, Akio Masuda, Taisuke Seki, Naoki Ishiguro, Kinji Ohno

Scientific reports Vol. 10 ( 1 ) page： 2995 - 2995 2020.2

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Papers - TAKEGAMI Yasuhiko