Updated on 2022/03/29

写真a

 
ITO Ayaka
 
Organization
Research Institute of Environmental Medicine Division of Stress Recognition and Response Lecturer
Graduate School
Graduate School of Medicine
Title
Lecturer
Contact information
メールアドレス

Degree 3

  1. Ph.D. (Medical Science) ( 2008.3   Tokyo Medical and Dental University ) 

  2. 修士(農学) ( 2004.3   京都大学 ) 

  3. 学士(生活環境学) ( 2002.3   奈良女子大学 ) 

Research Interests 6

  1. immunometabolism

  2. nuclear receptor

  3. lipid metabolism

  4. Autoimmune disease

  5. Immunology

  6. 心身相関

Research Areas 3

  1. Life Science / Pathological biochemistry

  2. Life Science / Nutrition science and health science  / 栄養学および健康科学

  3. Life Science / Metabolism and endocrinology

Current Research Project and SDGs 1

  1. 慢性炎症性疾患における脂質代謝の意義の解明

Research History 5

  1. Nagoya University   Lecturer

    2021.11

  2. Nagoya University   Lecturer

    2021.11

  3. Nagoya University   Research Institute of Environmental Medicine   Assistant Professor

    2018.4 - 2021.10

  4. Nagoya University   Research Institute of Environmental Medicine   Designated assistant professor

    2017.6 - 2018.3

  5. Nagoya University   Research Institute of Environmental Medicine   Researcher

    2016.9 - 2017.5

Education 3

  1. Tokyo Medical and Dental University

    2004.4 - 2008.3

      More details

    Country: Japan

  2. Kyoto University

    2002.4 - 2004.3

      More details

    Country: Japan

  3. Nara Women's University   Faculty of Living Environmental Studies

    1998.4 - 2002.3

      More details

    Country: Japan

Professional Memberships 6

  1. JAPAN SOCIETY FOR THE STUDY OF OBESITY

  2. JAPAN SOCIETY OF NUTRITION AND FOOD SCIENCE

  3. The Japan Endocrine Society

  4. THE JAPANESE SOCIETY FOR IMMUNOLOGY

  5. 日本脂質生化学会

  6. 日本生化学会

▼display all

Committee Memberships 1

  1. 日本内分泌学会   評議員  

    2020.4 - 2024.3   

      More details

    Committee type:Academic society

Awards 3

  1. Young Investigator Award

    2018   Japan Society of Molecular Medicine  

    Ayaka Ito

  2. 若手研究奨励賞

    2014   日本内分泌学会  

  3. 若手研究奨励賞

    2007   日本肥満学会  

 

Papers 19

  1. The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model. International journal

    Naoki Yoshioka, Miyako Tanaka, Kozue Ochi, Akiko Watanabe, Kenji Ono, Makoto Sawada, Tomoo Ogi, Michiko Itoh, Ayaka Ito, Yukihiro Shiraki, Atsushi Enomoto, Masatoshi Ishigami, Mitsuhiro Fujishiro, Yoshihiro Ogawa, Takayoshi Suganami

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie   Vol. 140   page: 111738 - 111738   2021.8

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Diabetes and obesity contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). However, how diabetes and obesity accelerate liver tumorigenesis remains to be fully understood. Moreover, to verify the therapeutic potential of anti-diabetic drugs, there exists a strong need for appropriate animal models that recapitulate human pathophysiology of NASH and HCC. METHODS: We established a novel murine model of NASH-associated liver tumors using genetically obese melanocortin 4 receptor-deficient mice fed on Western diet in combination with a chemical procarcinogen, and verified the validity of our model in evaluating drug efficacy. FINDINGS: Our model developed multiple liver tumors together with obesity, diabetes, and NASH within a relatively short period (approximately 3 months). In this model, sodium glucose cotransporter 2 inhibitor Tofogliflozin prevented the development of NASH-like liver phenotypes and the progression of liver tumors. Tofogliflozin attenuated p21 expression of hepatocytes in non-tumorous lesions in the liver. INTERPRETATION: Tofogliflozin treatment attenuates cellular senescence of hepatocytes under obese and diabetic conditions. This study provides a unique animal model of NASH-associated liver tumors, which is applicable for assessing drug efficacy to prevent or treat NASH-associated HCC.

    DOI: 10.1016/j.biopha.2021.111738

    Web of Science

    Scopus

    PubMed

  2. Dietary Supplementation With Eicosapentaenoic Acid Inhibits Plasma Cell Differentiation and Attenuates Lupus Autoimmunity

    Kobayashi Azusa, Ito Ayaka, Shirakawa Ibuki, Tamura Atsushi, Tomono Susumu, Shindou Hideo, Hedde Per Niklas, Tanaka Miyako, Tsuboi Naotake, Ishimoto Takuji, Akashi-Takamura Sachiko, Maruyama Shoichi, Suganami Takayoshi

    FRONTIERS IN IMMUNOLOGY   Vol. 12   page: 650856   2021.6

     More details

    Language:Japanese   Publisher:Frontiers in Immunology  

    Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with the development of autoimmune diseases. However, the mechanism by which fatty acid composition influences autoimmune responses remains unclear. To determine whether the fatty acid composition of diet modulates leukocyte function and the development of systemic lupus erythematosus, we examined the effect of eicosapentaenoic acid (EPA) on the pathology of lupus in drug-induced and spontaneous mouse models. We found that dietary EPA supplementation ameliorated representative lupus manifestations, including autoantibody production and immunocomplex deposition in the kidneys. A combination of lipidomic and membrane dynamics analyses revealed that EPA remodels the lipid composition and fluidity of B cell membranes, thereby preventing B cell differentiation into autoantibody-producing plasma cells. These results highlight a previously unrecognized mechanism by which fatty acid composition affects B cell differentiation into autoantibody-producing plasma cells during autoimmunity, and imply that EPA supplementation may be beneficial for therapy of lupus.

    DOI: 10.3389/fimmu.2021.650856

    Web of Science

    Scopus

    PubMed

  3. Macrophages rely on extracellular serine to suppress aberrant cytokine production. International journal

    Kento Kurita, Hiroya Ohta, Ibuki Shirakawa, Miyako Tanaka, Yasuyuki Kitaura, Yorihiro Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Seiichiro Aoe, Hiroshi Arima, Yoshihiro Ogawa, Ayaka Ito, Takayoshi Suganami

    Scientific reports   Vol. 11 ( 1 ) page: 11137 - 11137   2021.5

     More details

    Language:Japanese   Publishing type:Research paper (scientific journal)  

    A growing body of evidence indicates that cellular metabolism is involved in immune cell functions, including cytokine production. Serine is a nutritionally non-essential amino acid that can be generated by de novo synthesis and conversion from glycine. Serine contributes to various cellular responses, but the role in inflammatory responses remains poorly understood. Here, we show that macrophages rely on extracellular serine to suppress aberrant cytokine production. Depleting serine from the culture media reduced the cellular serine content in macrophages markedly, suggesting that macrophages depend largely on extracellular serine rather than cellular synthesis. Under serine deprivation, macrophages stimulated with lipopolysaccharide showed aberrant cytokine expression patterns, including a marked reduction of anti-inflammatory interleukin-10 expression and sustained expression of interleukine-6. Transcriptomic and metabolomics analyses revealed that serine deprivation causes mitochondrial dysfunction: reduction in the pyruvate content, the NADH/NAD+ ratio, the oxygen consumption rate, and the mitochondrial production of reactive oxygen species (ROS). We also found the role of mitochondrial ROS in appropriate cytokine production. Thus, our results indicate that cytokine production in macrophages is tightly regulated by the nutritional microenvironment.

    DOI: 10.1038/s41598-021-90086-w

    Web of Science

    Scopus

    PubMed

  4. NASHにおけるクッパー細胞鉄代謝の病態生理学的意義

    金森 耀平, 田中 都, 伊藤 美智子, 越智 梢, 伊藤 綾香, 日高 勲, 坂井田 功, 小川 佳宏, 菅波 孝祥

    日本内分泌学会雑誌   Vol. 97 ( 1 ) page: 255 - 255   2021.4

     More details

    Language:Japanese   Publisher:(一社)日本内分泌学会  

  5. Iron-rich Kupffer cells exhibit phenotypic changes during the development of liver fibrosis in NASH.

    Kanamori Y, Tanaka M, Itoh M, Ochi K, Ito A, Hidaka I, Sakaida I, Ogawa Y, Suganami T

    iScience   Vol. 24 ( 2 ) page: 102032   2021.2

     More details

  6. C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury

    Tanaka Miyako, Saka-Tanaka Marie, Ochi Kozue, Fujieda Kumiko, Sugiura Yuki, Miyamoto Tomofumi, Kohda Hiro, Ito Ayaka, Miyazawa Taiki, Matsumoto Akira, Aoe Seiichiro, Miyamoto Yoshihiro, Tsuboi Naotake, Maruyama Shoichi, Suematsu Makoto, Yamasaki Sho, Ogawa Yoshihiro, Suganami Takayoshi

    JOURNAL OF EXPERIMENTAL MEDICINE   Vol. 217 ( 11 )   2020.11

     More details

    Publisher:Journal of Experimental Medicine  

    DOI: 10.1084/jem.20192230

    Web of Science

    Scopus

    PubMed

  7. Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects

    Kawakubo Mitsuhiro, Tanaka Miyako, Ochi Kozue, Watanabe Akiko, Saka-Tanaka Marie, Kanamori Yohei, Yoshioka Naoki, Yamashita Satoko, Goto Moritaka, Itoh Michiko, Shirakawa Ibuki, Kanai Sayaka, Suzuki Hiromi, Sawada Makoto, Ito Ayaka, Ishigami Masatoshi, Fujishiro Mitsuhiro, Arima Hiroshi, Ogawa Yoshihiro, Suganami Takayoshi

    SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page: 983   2020.1

     More details

  8. Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.

    Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P

    Nature medicine   Vol. 24 ( 3 ) page: 304-312   2018.3

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/nm.4479

    PubMed

  9. Cholesterol accumulation in antigen presenting cells is a causal and targetable factor in autoimmune disease Reviewed

    Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Castrillo A, Bensinger SV, Chan L, Tontonoz P.

    Immunity   Vol. 45 ( 6 ) page: 1311 - 1326   2016

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  10. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling Reviewed

    Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P

    eLife   Vol. 4   page: e08009   2015

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  11. The macrophage lipopolysaccharide binging protein gene is an LXR target that promotes macrophage survival and atherosclerosis Reviewed

    Sallam T, Ito A, Rong X, Kim J, van Stijn C, Chamberlain BT, Jung ME, Chao LC, Jones M, Gilliland T, Wu X, Su GL, Tangirala RK, Tontonoz P, Hong C

    Journal of Lipid Research   Vol. 55   page: 1120 - 1130   2014

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  12. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Reviewed

    Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P.

    Cell Metabolism   Vol. 18   page: 685 - 697   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  13. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. Reviewed

    Chao L, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely O, Tangirala RK, Evans RM, Tontonoz P

    Journal of Lipid Research   Vol. 54   page: 806 - 815   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  14. Hormonal modulators of glial ABCA1 and apoE levels. Reviewed

    Fan J, Shimizu Y, Chan J, Wilkinson A, Ito A, Tontonoz P, Dullaghan E, Galea LA, Pfeifer T

    Journal of Lipid Research   Vol. 54   page: 3139 - 3150   2013

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  15. Coordinate regulation of neutrophil homeostasis by liver X receptors in mice Reviewed

    Hong C, Kidani Y, A-Gonzalez N, Phung T, Ito A, Rong X, Ericson K, Mikkola H, Beaven SW, Miller LS, Shao WH, Cohen PL, Castrillo A, Tontonoz P, Bensinger SJ

    Journal of Clinical Investigation   Vol. 122   page: 337 - 347   2012

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  16. Oxidative stress in the ischemic and non-ischemic parts of the rat liver after two-thirds ischemia/reperfusion Reviewed

    Kitamura Y, Washino Y, Koga E, Ito A, Kawagoe M, Nakazaki C, Kiso K, Ichi I, Matsura T, Kojo S

    Bioscience, Biotechnology, and Biochemistry   Vol. 74   page: 979 - 983   2010

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  17. Role of C-C chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue Reviewed

    Ito A, Suganami T, Yamauchi A, Degawa-Yamauchi M, Tanaka M , Kouyama R, Nitta N, Yasuda K, Hirata Y, Kuziel WA, Takeya M, Kanegasaki S, Kamei Y, and Ogawa Y

    Journal of Biological Chemistry   Vol. 283   page: 35715 - 35723   2008

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  18. Role of MAPK phosphatase-1 in the induction of monocyte chemoattractant protein-1 during the course of adipocyte hypertrophy Reviewed

    Ito A, Suganami T, Miyamoto Y, Yoshimasa Y, Takeya M, Kamei Y, and Ogawa Y

    Journal of Biological Chemistry   Vol. 282   page: 25445 - 25452   2007

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  19. FPRL1 receptor agonist peptides prevent etoposide-induced alopecia in neonatal rats Reviewed

    Tsuruki T, Ito A and Yoshikawa M

    Journal of Investigative Dermatology   Vol. 123   page: 242 - 243   2004

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

▼display all

Books 5

  1. 細胞内脂質代謝とイムノメタボリズム

    伊藤綾香、菅波孝祥( Role: Joint author)

    The Lipid. メディカルレビュー社  2019 

     More details

    Total pages:7   Language:Japanese

  2. 慢性炎症性疾患における脂質代謝異常の意義

    伊藤綾香、菅波孝祥( Role: Joint author)

    内分泌・糖尿病・代謝内科. 科学評論社  2019 

     More details

    Total pages:5   Language:Japanese

  3. 動脈硬化と自然免疫

    伊藤綾香、菅波孝祥( Role: Joint author)

    炎症と免疫. 先端医学社  2019 

     More details

    Total pages:5   Language:Japanese

  4. メタボリックシンドロームとリポクオリティ

    菅波孝祥、田中都、伊藤綾香、小川佳宏( Role: Joint author)

    実験医学. 羊土社  2018 

  5. 慢性炎症性疾患における脂質クオリティ

    伊藤綾香、菅波孝祥( Role: Joint author)

    医学のあゆみ. 医歯薬出版株式会社  2018 

     More details

    Language:Japanese

MISC 2

  1. Metabolic syndrome and lipoquality Invited

    Suganami T, Tanaka M, Ito A, Ogawa Y

    Experimental Medicine   Vol. 36 ( 10 ) page: 174 - 179   2018

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  2. Lipoquality in chronic inflammatory diseases Invited

    Ito A, Suganami T

    Journal of Clinical and Experimental Medicine   Vol. 264 ( 11 ) page: 944 - 948   2018

     More details

    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

Presentations 13

  1. Dietary supplementation with eicosapentaenoic acid inhibits plasma cell differentiation and attenuates lupus autoimmunity International coauthorship

    Ayaka Ito, Azusa Kobayashi, Ibuki Shirakawa, Atsushi Tamura, Susumu Tomono, Hideo Shindou, Per Niklas Hedde, Miyako Tanaka, Naotake Tsuboi, Takuji Ishimoto, Sachiko Akashi-Takamura, Shoichi Maruyama, Takayoshi Suganami

    2021.12 

     More details

    Event date: 2021.12

    Language:English  

  2. グリア内脂質代謝を介した脳-身体連関と末梢自己免疫応答制御の解明

    伊藤綾香

    文部科学省科研費 学術変革領域研究(A)「グリアデコーディング」第3回領域会議  2021.12 

     More details

    Event date: 2021.12

  3. 全身性自己免疫疾患における免疫細胞内脂肪酸組成の意義の解明

    伊藤綾香, 小林アズサ, 白川伊吹, 伴野勧, 田村篤志, 高村(赤司)祥子, 菅波孝祥

    第75回 日本栄養食糧学会大会  2021.7 

     More details

    Event date: 2021.7

    Language:Japanese  

  4. 全身性エリテマトーデスにおける免疫細胞内脂肪酸組成の意義の解明

    伊藤綾香, 小林アズサ, 白川伊吹, 伴野勧, 田村篤志, 菅波孝祥

    第94回日本内分泌学会学術総会  2021.4 

     More details

    Event date: 2021.4

    Language:Japanese  

  5. 自己免疫応答におけるオメガ3脂肪酸の意義

    伊藤綾香, 小林アズサ, 白川伊吹, 菅波孝祥

    第74回日本栄養・食糧学会大会 

     More details

    Event date: 2020.5

  6. 自己免疫応答におけるオメガ3脂肪酸の意義

    伊藤綾香, 小林アズサ, 白川伊吹, 菅波孝祥

    第62回日本脂質生化学会 

     More details

    Event date: 2020.5

    Language:Japanese  

  7. Dietary supplementation of omega-3 fatty acid in mouse models of systemic lupus erythematosus

    Ito A, Kobyashi A, Suganami T

     More details

    Event date: 2019.12

  8. Cholesterol accumulation in CD11c+ immune cells is a causal and targetable factor in autoimmune disease International coauthorship

    Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P

    The 47th Annual Meeting of the Japanese Society for Immunology  2018.12.11 

     More details

    Event date: 2018.12

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  9. Molecular crosstalk between cholesterol metabolism and immune responses Invited International conference

    Ayaka Ito

    The 4th IMCR Symposium on endocrine and metabolism  2018.11.9 

     More details

    Event date: 2018.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Gunma   Country:Japan  

  10. Molecular crosstalk between lipid metabolism and immune responses Invited International coauthorship

    Ito A, Hong C, Tontonoz P, Suganami T

    The 36th JES Summer Seminar Endocrinology & Metabolism  2018.8 

     More details

    Event date: 2018.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  11. Cholesterol accumulation in CD11c+ immune cells is a causal and targetable factor in autoimmune disease International coauthorship International conference

    Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P

    Cell Symposia  2018.6 

     More details

    Event date: 2018.6

    Language:English   Presentation type:Poster presentation  

    Venue:Basel   Country:Switzerland  

  12. Cellular cholesterol metabolism in autoimmune disease

    Ito A, Hong C, Tontonoz P, Suganami T

    The 91st Annual Meeting of the Japan Endocrine Society  2018.4 

     More details

    Event date: 2018.4

    Language:Japanese   Presentation type:Oral presentation (general)  

  13. 自己免疫疾患発症における細胞内コレステロール代謝の意

    伊藤綾香、Cynthia Hong、Peter Tontonoz、菅波孝祥

    第55回日本臨床分子医学会学術集会  2018.4 

     More details

    Event date: 2018.4

▼display all

Research Project for Joint Research, Competitive Funding, etc. 6

  1. 免疫細胞内脂質に着目した全身エリテマトーデスの病態解明

    2021.4 - 2022.3

    公益財団法人稲盛財団 2021年度稲盛研究助成 

      More details

    Authorship:Principal investigator  Grant type:Competitive

  2. 細胞内脂質による免疫応答の制御機構と自己免疫疾患予防への応用

    2021 - 2023

    公益財団法人ロッテ財団 第8回(2021年度)奨励研究助成 

      More details

    Authorship:Principal investigator  Grant type:Competitive

  3. 細胞内脂質代謝に着目した自己免疫疾患の 新たな病態メカニズムの解明

    2020.4 - 2022.3

    公益財団法人加藤記念バイオサイエンス振興財団 第31回(2019年度)加藤記念研究助成 

      More details

    Authorship:Principal investigator  Grant type:Competitive

  4. 慢性炎症性疾患における細胞内脂質代謝の意義の解明

    2020.1 - 2020.12

    公益財団法人興和生命科学振興財団 2019年度研究助成 

      More details

    Authorship:Principal investigator  Grant type:Competitive

  5. 慢性炎症性疾患における脂質代謝の意義の解明

    2020 - 2022

    公益財団法人武田科学振興財団 2020年度ビジョナリーリサーチ継続助成(ホップ) 

      More details

    Authorship:Principal investigator  Grant type:Competitive

  6. 慢性炎症性疾患における脂質代謝の意義の解明

    2019.11 - 2020.11

    花王健康科学研究会 第17回(2019年度)研究助成 

      More details

    Authorship:Principal investigator  Grant type:Competitive

▼display all

KAKENHI (Grants-in-Aid for Scientific Research) 4

  1. グリア内脂質代謝を介した脳-身体連関と末梢自己免疫応答制御の解明

    Grant number:21H05625  2021.9 - 2023.3

    科学研究費助成事業  学術変革領域研究(A)

    伊藤 綾香

      More details

    Authorship:Principal investigator 

    Grant amount:\7800000 ( Direct Cost: \6000000 、 Indirect Cost:\1800000 )

  2. 慢性炎症性疾患の免疫細胞における脂質リプログラミングの意義の解明

    Grant number:19KK0249  2019.10 - 2023.3

    国際共同研究加速基金(国際共同研究強化(B))

    伊藤 綾香

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\16770000 ( Direct Cost: \12900000 、 Indirect Cost:\3870000 )

    近年、種々の疾患に共通の基盤病態として慢性炎症が注目されているが、その分子機構は未だ十分に理解されておらず、特に免疫細胞内の脂質代謝異常の関与は不明である。本研究では、慢性炎症性の遷延化に伴う免疫細胞内脂質の量的・質的変化とその分子機構を明らかにする。また、自己免疫疾患と肥満を比較解析することにより、疾患特異的な、あるいは慢性炎症性疾患に共通の脂質リプログラミングの分子機構を解明し、治療標的としての可能性を検証する。本研究により、細胞内脂質代謝という従来にない切り口で疾患特異的な慢性炎症化の機構が明らかになるのみならず、慢性炎症性疾患の新しい診断・予防・治療の提案につながると期待される。

  3. Quality and amount of lipid in autoimmune diseases

    Grant number:19K11765  2019.4 - 2022.3

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  4. Pathophysiological relevance of intracellular cholesterol metabolism in autoimmune diseases

    Grant number:17K16146  2017.4 - 2019.3

    Ito Ayaka

      More details

    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4160000 ( Direct Cost: \3200000 、 Indirect Cost:\960000 )

    In this study, we analyzed genetic and drug-induced SLE model mice and elucidated that titers of autoantibodies and deposition of immunoglobulin in kidney were increased in the SLE model mice compared to the control mice. We also found that lipid content in immune cells was higher in SLE than control mice, and which was observed at the beginning of the development of SLE. On the other hand, there was no difference in serum lipid profile and hepatic gene expression of lipid metabolism between SLE and control mice. Administration of an agent to improve systemic lipid metabolism prevented the development of SLE. These findings suggest that lipid accumulation in immune cells is cell intrinsic effect and improvement of systemic lipid metabolism could be beneficial in the setting of autoimmune disease.

 

Teaching Experience (On-campus) 3

  1. 自然科学と人間

    2021

  2. 自然科学と人間

    2020

  3. Studium Generale

    2019

Teaching Experience (Off-campus) 1

  1. 加齢学

    2019 Shigakkan University)

 

Social Contribution 9

  1. 令和3年度・後期 岩倉市生涯学習講座「時間栄養学・体内時計に基づく健康的な食べ方」

    Role(s):Lecturer

    2022.3

  2. 令和3年度・後期 岩倉市生涯学習講座「塩の魅力と脅威」

    Role(s):Lecturer

    2022.2

  3. 令和3年度・後期 岩倉市生涯学習講座「タンパク質のはたらきと私たちの健康」

    Role(s):Lecturer

    2022.1

  4. 令和3年度在宅保健師会「あいち」第2回研修会「予防医学としての食を学ぶ・発酵食品のパワーと魅力」

    Role(s):Lecturer

    2021.10

  5. CBCラジオ「健康長寿の食」

    Role(s):Commentator

    2021.3

  6. 令和2年度・後期 岩倉市生涯学習講座「外出自粛時の食生活対策」

    Role(s):Lecturer

    2021.3

  7. 令和2年度・後期 岩倉市生涯学習講座「血管の欠陥」

    Role(s):Lecturer

    2021.2

  8. 令和2年度・後期 岩倉市生涯学習講座「感染症と免疫」

    Role(s):Lecturer

    2021.1

  9. CareTEX名古屋「認知症を予防する食事」

    Role(s):Lecturer

    2021.1

▼display all