Updated on 2021/08/30

写真a

 
SOBUE Akira
 
Organization
Research Institute of Environmental Medicine Division of Stress Recognition and Response Designated assistant professor
Title
Designated assistant professor

Degree 1

  1. 博士(医学) ( 2018.3   名古屋大学 ) 

Research Interests 5

  1. グリア細胞

  2. 神経炎症

  3. 行動薬理学

  4. アルツハイマー病

  5. ミクログリア

Research Areas 2

  1. Life Science / Pathophysiologic neuroscience

  2. Life Science / Pharmacology

Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2018.3

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    Country: Japan

  2. Osaka University of Pharmaceutical Sciences   Faculty of Pharmaceutical Science

    - 2014.3

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    Country: Japan

Professional Memberships 5

  1. 日本認知症学会

  2. The International Behavioral Neuroscience Society

  3. 日本神経科学会

  4. 日本神経精神薬理学会

  5. 日本薬理学会

Awards 4

  1. 第39回日本認知症学会 学会奨励賞

    2020.11   日本認知症学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. JSNP Excellent Presentation Award for AsCNP 2017 Bali

    2017.4   日本神経精神薬理学会  

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    Award type:Award from international society, conference, symposium, etc.  Country:Indonesia

  3. 第9回NAGOYAグローバルリトリート 優秀発表賞

    2017.2   名古屋大学  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  4. 第18回応用薬理シンポジウム 優秀演題賞

    2016.8   応用薬理研究会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

 

Papers 18

  1. Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis Reviewed

    Sakai S, Watanabe S, Komine O, Sobue A, Yamanaka K.

    FASEB J .   Vol. 35 ( 7 ) page: e21688   2021.7

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    Language:English  

    DOI: 10.1096/fj.202100137R.

  2. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Reviewed

    Hada K, Wulaer B, Nagai T, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K

    Molecular brain   Vol. 14 ( 1 ) page: 21 - 21   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13041-021-00735-4

  3. Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease Reviewed

    Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido TC, Sahara N, Higuchi M, Ogi T, Yamanaka K.

    Acta neuropathologica communications   Vol. 9 ( 1 ) page: 1   2021.1

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  4. Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia Reviewed

    Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K

    Neurochemistry international     page: 104954   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neuint.2020.104954.

  5. Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice Reviewed

    Wulaer B, Hada K, Sobue A, Itoh N, Nabeshima T, Nagai T, Yamada K

    Molecular brain   Vol. 13 ( 1 ) page: 170   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13041-020-00710-5.

  6. Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease Reviewed

    Saifullah MD Ali, Komine O, Dong Y, Fukumoto K, Sobue A, Endo F, Saito T, Saido T, Yamanaka K, Mizoguchi H

    Molecular Brain   Vol. 13 ( 1 ) page: 147   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13041-020-00690-6.

  7. Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43. Invited Reviewed

    Watanabe S, Inami H, Oiwa K, Murata Y, Sakai S, Komine O, Sobue A, Iguchi Y, Katsuno M, Yamanaka K

    Cell death & disease   Vol. 11 ( 10 ) page: 909 - 909   2020.10

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  8. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk Reviewed

    Mariko Sekiguchi, Akira Sobue, Itaru Kushima, Chenyao Wang, Yuko Arioka, Hidekazu Kato, Akiko Kodama, Hisako Kubo, Norimichi Ito, Masahito Sawahata, Kazuhiro Hada, Ryosuke Ikeda, Mio Shinno, Chikara Mizukoshi, Keita Tsujimura, Akira Yoshimi, Kanako Ishizuka, Yuto Takasaki, Hiroki Kimura, Jingrui Xing, Yanjie Yu, Maeri Yamamoto, Takashi Okada, Emiko Shishido, Toshiya Inada, Masahiro Nakatochi, Tetsuya Takano, Keisuke Kuroda, Mutsuki Amano, Branko Aleksic, Takashi Yamomoto, Tetsushi Sakuma, Tomomi Aida, Kohichi Tanaka, Ryota Hashimoto, Makoto Arai, Masashi Ikeda, Nakao Iwata, Teppei Shimamura, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Kiyofumi Yamada, Daisuke Mori, Norio Ozaki

    Translational Psychiatry   Vol. 10 ( 1 ) page: 247   2020.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41398-020-00917-z.

  9. Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.

    Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T

    Cell     2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cell.2020.02.010

    PubMed

  10. Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia.

    Sawahata M, Mori D, Arioka Y, Kubo H, Kushima I, Kitagawa K, Sobue A, Shishido E, Sekiguchi M, Kodama A, Ikeda R, Aleksic B, Kimura H, Ishizuka K, Nagai T, Kaibuchi K, Nabeshima T, Yamada K, Ozaki N

    Psychiatry and clinical neurosciences     2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pcn.12993

    Scopus

    PubMed

  11. ALS-linked TDP-43<sup>M337V</sup> knock-in mice exhibit splicing deregulation without neurodegeneration.

    Watanabe S, Oiwa K, Murata Y, Komine O, Sobue A, Endo F, Takahashi E, Yamanaka K

    Molecular brain   Vol. 13 ( 1 ) page: 8   2020.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13041-020-0550-4

    PubMed

  12. Morphological changes in striatum and nucleus accumbens neurons lead to abnormal behavior in ARHGAP10 mutant mice

    Hada Kazuhiro, Ozaki Norio, Yamada Kiyofumi, Wulaer Bolati, Nagai Taku, Sbue Akira, Sawahata Masahito, Itoh Norimichi, Mori Daisuke, Kushima Itaru, Nabeshima Toshitaka

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   Vol. 93 ( 0 ) page: 2-YIA-52   2020

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    Language:English   Publishing type:Research paper (scientific journal)  

    <p>Schizophrenia is a severe mental illness that affects about 1% of the population. Genetic and environmental factors contribute to the development of schizophrenia. However, the exact pathoetiology remains unclear. We generated Rho GTPase-activating protein 10 (ARHGAP10) mutant mice carrying similar variations found in Japanese schizophrenia patients. In the present study, we examined spatiotemporal expression of ARHGAP10 mRNA in the brain of mice. The expression levels of ARHGAP10 mRNA were higher in the striatum (ST) and nucleus accumbens (NAc) than those in other brain regions. We performed a series of behavior test to evaluate cognitive and emotional function in ARHGAP10 mutant mice. They showed an increase in anxiety level, and manifested potentiation of methamphetamine-induced hyperlocomotion and visual discrimination task. Morphological analysis revealed that methamphetamine-treated ARHGAP10 mutant mice showed an increase in the number of c-Fos-positive-cells in the dorsal medial striatum (dmST) and NAc core than those in wild-type littermates. Golgi staining indicated that ARHGAP10 mutant mice showed an increase in neuronal complexity and spine density in the same brain regions compared to the wild-type mice. These results suggest that ARHGAP10 gene variations may lead to the development of cognitive and emotional deficits with morphological abnormality in the dmST and NAc core neurons.</p>

    DOI: 10.1254/jpssuppl.93.0_2-YIA-52

    CiNii Article

  13. Behavioral characterization of APP knock-in mice model in touchscreen-based tests aiming early detection of Alzheimer's disease.

    Saifullah MD. Ali Bin, Komine Okiru, Sobue Akira, Yamanaka Koji, Mizoguchi Hiroyuki

    Proceedings for Annual Meeting of The Japanese Pharmacological Society   Vol. 92 ( 0 ) page: 1-P-041   2019

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    Language:English   Publishing type:Research paper (scientific journal)  

    <p>Alzheimer's disease (AD) is a progressive disease characterized by loss of memory and other important mental functions. Accumulation of amyloid beta (Aβ) and fibrillary tangles are the main pathological hallmarks of this disease. Emerging data suggest that the disease process begins years before clinical diagnostic confirmation; thus, methods to improve early detection would provide opportunities for early intervention to delay progressive cognitive decline and disease onset. In our research we assessed the cognitive abilities of <i>APP</i><sup><i>NL-G-F/NL-G-F</i></sup> knock-in (<i>APP-</i>KI) mice with a touch screen-based automated test battery and water maze test. These tests are mainly dependent on the brain regions that are prone to Aβ accumulation at the earliest stages of the disease. We subjected male 6- and 11-months old <i>APP-</i>KI mice in water maze test where only older mice showed significantly worsened behavior than wild-type mice. However, using touchscreen based behavioral test it was possible to detect cognitive impairment in <i>APP-</i>KI mice at an early (4 months) stage while classical behavioral tests shows comparable results between wild-type and disease model mice. </p>

    DOI: 10.1254/jpssuppl.92.0_1-P-041

    CiNii Article

  14. Repetitive and compulsive‐like behaviors lead to cognitive dysfunction in Disc1 Δ2‐3/Δ2‐3mice

      Vol. 17 ( 8 ) page: e12478   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/gbb.12478

  15. Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia Reviewed

    Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N

    Sci Rep.     2018.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-31390-w

  16. Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes Reviewed

    Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K

    GLIA   Vol. 66 ( 5 ) page: 1034-1052   2018.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/glia.23299

  17. Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice Reviewed

    Shimizu S, Mizuguchi Y, Sobue A, Fujiwara M, Morimoto T, Ohno Y

    J Pharmacol Sci     2015

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jphs.2015.03.004

  18. 5-HT1A agonist alleviates serotonergic potentiation of extrapyramidal disorders via postsynaptic mechanisms Reviewed

    Shimizu S, Mizuguchi Y, Tatara A, Kizu T, Andatsu S, Sobue A, Fujiwara M, Morimoto T, Ohno Y

    Prog Neuropsychopharmacol Biol Psychiatry     2013

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.pnpbp.2013.06.016

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Books 4

  1. アルツハイマー病におけるTREM2と脳内各種細胞の関連について

    祖父江顕( Role: Sole author)

    日本薬学会  2020.11 

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    Language:Japanese Book type:Scholarly book

  2. 神経変性疾患におけるミクログリア. 特徴と治療標的としての展望.

    祖父江 顕、山中宏二( Role: Joint author)

    医歯薬出版株式会社  2020.6 

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    Language:Japanese

  3. ストレス科学:末梢性免疫炎症反応に伴うアストロサイトにおけるMHC Class I分子の発現誘導が脳機能に及ぼす影響

    祖父江顕、永井拓、山田清文( Role: Joint author)

    日本ストレス学会  2019 

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    Language:Japanese

  4. 実験医学 疾患を制御するマクロファージの多様性

    祖父江顕、遠藤史人、山中宏二( Role: Joint author)

    羊土社  2018.8 

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    Language:Japanese Book type:Scholarly book

Presentations 29

  1. Downregulation of homeostatic microglial genes is correlated with progression of Alzheimer's disease in mice

    Akira Sobue, Okiru Komine, Yuichiro Hara, Fumito Endo, Hiroyuki Mizoguchi, Seiji Watanabe, Shigeo Murayama, Takashi Saito, Takaomi C Saido, Naruhiko Sahara, Makoto Higuchi, Tomoo Ogi, Koji Yamanaka

    2021.7.31 

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    Event date: 2021.7

    Language:English   Presentation type:Poster presentation  

  2. ミクログリアのカンナビノイド受容体2型を介したアルツハイマー病における神経炎症調節機構について

    ○祖父江顕、小峯起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二

    第139回日本薬理学会近畿部会  2021.6.26 

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    Event date: 2021.6

    Language:Japanese   Presentation type:Oral presentation (general)  

  3. ADにおけるミクログリアのカンナビノイド受容体2型を介した神経炎症調節機構について

    祖父江顕、小峯起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二

    第39回日本認知症学会学術集会 

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    Event date: 2020.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  4. ミクログリアのカンナビノイド 受容体2型を標的としたアルツハイマー病治療法開発 Invited

    祖父江 顕, 小峯 起, 遠藤 史人, 村山 繁雄, 斉藤 貴志, 西道 隆臣, 山中 宏二

    第1回脳科学サロン  2020.8.15 

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    Event date: 2020.8

    Language:Japanese   Presentation type:Poster presentation  

  5. Microglial cannabinoid receptor type II as potential therapeutic target for Alzheimer's disease.

    Sobue A, Komine O, Endo F, Shigeo Murayama S, Saito T, Saido TC, Yamanaka K.

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    Event date: 2020.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  6. アルツハイマー病患者とAppNL-G-F マウスにおける神経炎症関連遺伝⼦解析

    祖父江 顕、小峯 起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二

    第38回日本認知症学会学術集会 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  7. アルツハイマー病患者脳とAPP- KIマウス由来ミクログリアにおける遺伝子発現解析

    祖父江 顕、小峯 起、遠藤史人、村山繁雄、斉藤貴志、西道 隆臣、山中宏二

    第42回日本神経科学大会第62回日本神経化学会大会 

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    Event date: 2019.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:新潟   Country:Japan  

  8. Profiling of gene expression in Alzheimer's disease patients and APP-KI mouse model demonstrates a link between amyloid pathology and microglial phenotype

    Akira Sobue, Okiru Komine, Fumito Endo, Shigeo Murayama, Koji Yamanaka

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    Event date: 2019.2

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  9. 早期アルツハイマー病理を呈する患者脳における神経炎症関連遺伝子発現解析

    祖父江顕、遠藤史人、小峯起、村山繁雄、山中宏二

    第37回日本認知症学会学術集会 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  10. The pathophysiological role of astroglial MHCI following systemic immune activation

    Akira Sobue, Norimichi Ito, Kazuhiro Hada, Akira Nakajima, Murakami Yuki, Mouri akihiro, Yamamoto Yasuko, Toshitaka Nabeshima, Kuniaki Saito, Taku Nagai, Kiyofumi Yamada

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    Event date: 2018.8

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  11. The pathophysiological role of astroglial MHCI following immune activation

    Akira Sobue, Norimichi Ito, Wei Shan, Kazuhiro Hada, Akira Nakajima, Yuki Murakami, Akihiro Mouri, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito, Taku Nagai, Kiyofumi Yamada

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    Event date: 2018.2

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  12. Astroglial MHCI following immune activation leads to behavioral and neuropathological abnormalities

    Akira Sobue, Norimichi Ito, Wei Shan, Kazuhiro Hada, Akira Nakajima, Yuki Murakami, Akihiro Mouri, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito, Taku Nagai, Kiyofumi Yamada

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  13. Astroglial MHCI expression and its behavioral and neuropathological implications

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    Event date: 2017.9

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  14. Peripheral immune activation leads to the expression of MHCI molecules in the cortex of mice.

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    Event date: 2017.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  15. 末梢免疫活性が及ぼすマウス大脳皮質における免疫関連因子の発現誘導

    祖父江 顕, 伊藤 教道, 羽田 和弘, 中島 晶, 村上 由希, 毛利 彰宏, 山本 康子, 鍋島俊隆, 齋藤 邦明, 永井 拓, 山田 清文

    第 131 回日本薬理学会近畿部会  

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  16. Exosomal MHCI derived from astrocytes leads to behavioral and neuropathological abnormalities in mice International conference

    Akira Sobue, Norimichi Ito, Kazuhiro Hada, Akira Nakajima, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

    International Behavioral Neuroscience Society for the 26th Annual Meeting 

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    Event date: 2017.6

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  17. Behavioral and neurochemical abnormalities in MHCI-expressed mice International conference

    Akira Sobue, Norimichi Ito, Kazuhiro Hada, Akira Nakajima, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

    The 5th Congress of Asian College of Neuropsychopharmacology 

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    Event date: 2017.4

    Language:English   Presentation type:Poster presentation  

    Country:Indonesia  

  18. Behavioral alterations accompanied by neuropathological changes induced by the expression of MHCI in the prefrontal cortex of mice

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    Event date: 2017.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  19. Expression of MHCI in astrocyte leads to behavioral and neuropathological abnormalities

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    Event date: 2017.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  20. Reln rl-Orl/+ mice show behavioral abnormalities in emotion, social interaction and motor learning: association with dopaminergic dysfunction International conference

    Akira Sobue, Yuki Aoyama, Shan Wei, Taku Nagai, Kiyofumi Yamada

    Dopamine 2016 

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    Event date: 2016.9

    Language:English   Presentation type:Poster presentation  

    Country:Austria  

  21. アストロサイトにおける MHC Class I の発現が行動に及ぼす影響と神経科学的解析

    祖父江顕、伊藤教道、羽田和弘、中島晶、永井拓、鍋島俊隆、山田清文

    第 18 回応用薬理シンポジウム 

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    Event date: 2016.8

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  22. アストロサイトにおける MHCI の発現が社会性行動および認知機能へ及ぼす影響

    祖父江顕、伊藤教道、羽田和弘、中島晶、永井拓、鍋島俊隆、山田清文

    第 89 回日本薬理学会年会 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  23. 統合失調症モデルマウスとしての Orleans reeler マウスの行動評価と神経科学的解析

    祖父江顕、青山雄紀、Wei Shan、永井拓、山田清文

    第 25 回神経行動薬理若手研究者の集い  

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  24. Expression of MHC class I gene in astrocytes impaires social behavior, cognitive function and sensorimotor gating in mice

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    Event date: 2016.2

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  25. アストロサイトにおける MHC Class I の過剰発現が行動に及ぼす影響

    祖父江顕、伊藤教道、中島晶、永井拓、山田清文

    第 128 回日本薬理学会近畿部会  

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    Event date: 2015.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  26. 中枢神経系における MHC Class I の細胞内局在と分泌機構について

    祖父江顕、伊藤教道、中島晶、永井拓、山田清文

    第 88 回日本薬理学会年 

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    Event date: 2015.3

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  27. The localization and secretion of MHC class I molecules in neuronal and glial cells

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    Event date: 2015.2

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  28. 認知症治療薬による錐体外路障害に対するセロトニン作用薬の評価

    祖父江顕、清水佐紀、水口裕登、藤原麻衣、森本朋樹、大野行弘

    第 63 回日本薬学会近畿支部総会・大会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  29. 認知症治療薬による錐体外路障害助長に対するセロトニン神経作用薬の影響

    祖父江顕、清水佐紀、水口裕登、藤原麻衣、森本朋樹、大野行弘

    生体機能と創薬シンポジウム 2013 

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    Event date: 2013.8

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 3

  1. グリア細胞を標的としたアルツハイマー病の新規治療候補分子探索とその機能解析

    Grant number:20K16488  2020.4 - 2023.3

    科学研究費補助金  若手研究

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

  2. タンパク質の構造生物学に基づいた筋萎縮性側索硬化症の分子病態解明と治療法開発

    Grant number:19KK0214  2019.10 - 2024.3

    科学研究費補助金  国際共同研究加速基金(国際共同研究強化(B))

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    Authorship:Coinvestigator(s) 

    Grant amount:\18330000 ( Direct Cost: \14100000 、 Indirect Cost:\4230000 )

  3. ミクログリアによる神経炎症に着目したアルツハイマー病の分子病態解明とその制御

    Grant number:19K21221  2018.8 - 2020.3

    科学研究費補助金  研究活動スタート支援

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    Authorship:Principal investigator 

    Grant amount:\2990000 ( Direct Cost: \2300000 、 Indirect Cost:\690000 )

 

Teaching Experience (On-campus) 4

  1. 基盤医科学実習

    2021

  2. 基盤医科学実習

    2020

  3. 基盤医科学実習

    2019

  4. 基盤医科学実習

    2018