International Society for Neurochemistry

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis Reviewed

Kotaro Oiwa, Seiji Watanabe, Kazunari Onodera, Yohei Iguchi, Yukako Kinoshita, Okiru Komine, Akira Sobue, Yohei Okada, Masahisa Katsuno, Koji Yamanaka

Science Advances   Vol. 9 ( 31 )   2023.8

Neuroinflammation in Alzheimer's disease: microglial signature and their relevance to disease Invited Reviewed

Akira Sobue, Okiru Komine, Koji Yamanaka

Inflammation and regeneration   Vol. 43 ( 1 ) page： 26 - 26   2023.5

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis. Reviewed

Seiji Watanabe, Mai Horiuchi, Yuri Murata, Okiru Komine, Noe Kawade, Akira Sobue, Koji Yamanaka

Neurobiology of disease   Vol. 179   page： 106031   2023.2

Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia Reviewed

Saeko Takase, Jingzhu Liao, Yue Liu, Rinako Tanaka, Yasuhiro Miyagawa, Masahito Sawahata, Akira Sobue, Hiroyuki Mizoguchi, Taku Nagai, Kozo Kaibuchi, Norio Ozaki, Kiyofumi Yamada

European Journal of Pharmacology     page： 175207 - 175207   2022.8

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis Reviewed

Sakai S, Watanabe S, Komine O, Sobue A, Yamanaka K.

FASEB J .   Vol. 35 ( 7 ) page： e21688   2021.7

Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Reviewed

Hada K, Wulaer B, Nagai T, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K

Molecular brain   Vol. 14 ( 1 ) page： 21 - 21   2021.1

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease Reviewed

Sobue A, Komine O, Hara Y, Endo F, Mizoguchi H, Watanabe S, Murayama S, Saito T, Saido TC, Sahara N, Higuchi M, Ogi T, Yamanaka K.

Acta neuropathologica communications   Vol. 9 ( 1 ) page： 1   2021.1

Analysis of Reelin signaling and neurodevelopmental trajectory in primary cultured cortical neurons with RELN deletion identified in schizophrenia Reviewed

Tsuneura Y, Sawahata M, Itoh N, Miyajima R, Mori D, Kohno T, Hattori M, Sobue A, Nagai T, Mizoguchi H, Nabeshima T, Ozaki N, Yamada K

Neurochemistry international     page： 104954   2020.12

Overexpression of astroglial major histocompatibility complex class I in the medial prefrontal cortex impairs visual discrimination learning in mice Reviewed

Wulaer B, Hada K, Sobue A, Itoh N, Nabeshima T, Nagai T, Yamada K

Molecular brain   Vol. 13 ( 1 ) page： 170   2020.12

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease Reviewed

Saifullah MD Ali, Komine O, Dong Y, Fukumoto K, Sobue A, Endo F, Saito T, Saido T, Yamanaka K, Mizoguchi H

Molecular Brain   Vol. 13 ( 1 ) page： 147   2020.11

Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43. Invited Reviewed

Watanabe S, Inami H, Oiwa K, Murata Y, Sakai S, Komine O, Sobue A, Iguchi Y, Katsuno M, Yamanaka K

Cell death & disease   Vol. 11 ( 10 ) page： 909 - 909   2020.10

ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk Reviewed

Mariko Sekiguchi, Akira Sobue, Itaru Kushima, Chenyao Wang, Yuko Arioka, Hidekazu Kato, Akiko Kodama, Hisako Kubo, Norimichi Ito, Masahito Sawahata, Kazuhiro Hada, Ryosuke Ikeda, Mio Shinno, Chikara Mizukoshi, Keita Tsujimura, Akira Yoshimi, Kanako Ishizuka, Yuto Takasaki, Hiroki Kimura, Jingrui Xing, Yanjie Yu, Maeri Yamamoto, Takashi Okada, Emiko Shishido, Toshiya Inada, Masahiro Nakatochi, Tetsuya Takano, Keisuke Kuroda, Mutsuki Amano, Branko Aleksic, Takashi Yamomoto, Tetsushi Sakuma, Tomomi Aida, Kohichi Tanaka, Ryota Hashimoto, Makoto Arai, Masashi Ikeda, Nakao Iwata, Teppei Shimamura, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Kiyofumi Yamada, Daisuke Mori, Norio Ozaki

Translational Psychiatry   Vol. 10 ( 1 ) page： 247   2020.7

Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair.

Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T

Cell     2020.2

Generation and analysis of novel Reln-deleted mouse model corresponding to exonic Reln deletion in schizophrenia.

Sawahata M, Mori D, Arioka Y, Kubo H, Kushima I, Kitagawa K, Sobue A, Shishido E, Sekiguchi M, Kodama A, Ikeda R, Aleksic B, Kimura H, Ishizuka K, Nagai T, Kaibuchi K, Nabeshima T, Yamada K, Ozaki N

Psychiatry and clinical neurosciences     2020.2

ALS-linked TDP-43^M337V knock-in mice exhibit splicing deregulation without neurodegeneration.

Watanabe S, Oiwa K, Murata Y, Komine O, Sobue A, Endo F, Takahashi E, Yamanaka K

Molecular brain   Vol. 13 ( 1 ) page： 8   2020.1

Morphological changes in striatum and nucleus accumbens neurons lead to abnormal behavior in ARHGAP10 mutant mice

Hada Kazuhiro, Ozaki Norio, Yamada Kiyofumi, Wulaer Bolati, Nagai Taku, Sbue Akira, Sawahata Masahito, Itoh Norimichi, Mori Daisuke, Kushima Itaru, Nabeshima Toshitaka

Proceedings for Annual Meeting of The Japanese Pharmacological Society   Vol. 93 ( 0 ) page： 2-YIA-52   2020

Behavioral characterization of APP knock-in mice model in touchscreen-based tests aiming early detection of Alzheimer's disease.

Saifullah MD. Ali Bin, Komine Okiru, Sobue Akira, Yamanaka Koji, Mizoguchi Hiroyuki

Proceedings for Annual Meeting of The Japanese Pharmacological Society   Vol. 92 ( 0 ) page： 1-P-041   2019

Repetitive and compulsive‐like behaviors lead to cognitive dysfunction in Disc1 ^{Δ2‐3/Δ2‐3}mice Reviewed

  Vol. 17 ( 8 ) page： e12478   2018.11

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia Reviewed

Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N

Sci Rep.     2018.8

Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes Reviewed

Sobue A, Ito N, Nagai T, Shan W, Hada K, Nakajima A, Murakami Y, Mouri A, Yamamoto Y, Nabeshima T, Saito K, Yamada K

GLIA   Vol. 66 ( 5 ) page： 1034-1052   2018.5

Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice Reviewed

Shimizu S, Mizuguchi Y, Sobue A, Fujiwara M, Morimoto T, Ohno Y

J Pharmacol Sci     2015

5-HT1A agonist alleviates serotonergic potentiation of extrapyramidal disorders via postsynaptic mechanisms Reviewed

Shimizu S, Mizuguchi Y, Tatara A, Kizu T, Andatsu S, Sobue A, Fujiwara M, Morimoto T, Ohno Y

Prog Neuropsychopharmacol Biol Psychiatry     2013

アルツハイマー病の病態進行に伴いミクログリアの生理機能が低下する

祖父江 顕,小峯 起,原 雄一郎, 遠藤史人,溝口博之,渡邊征爾,村山繁雄, 斉藤貴志,西道隆臣,佐原成彦,樋口真人, 荻 朋男,山中宏二

第40回日本認知症学会学術集会  2021.11 

Downregulation of homeostatic microglial genes is correlated with progression of Alzheimer's disease in mice

Akira Sobue, Okiru Komine, Yuichiro Hara, Fumito Endo, Hiroyuki Mizoguchi, Seiji Watanabe, Shigeo Murayama, Takashi Saito, Takaomi C Saido, Naruhiko Sahara, Makoto Higuchi, Tomoo Ogi, Koji Yamanaka

2021.7.31 

ミクログリアのカンナビノイド受容体2型を介したアルツハイマー病における神経炎症調節機構について

○祖父江顕、小峯起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二

第139回日本薬理学会近畿部会  2021.6.26 

ADにおけるミクログリアのカンナビノイド受容体2型を介した神経炎症調節機構について

祖父江顕、小峯起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二

第39回日本認知症学会学術集会 

ミクログリアのカンナビノイド 受容体２型を標的としたアルツハイマー病治療法開発 Invited

祖父江 顕, 小峯 起, 遠藤 史人, 村山 繁雄, 斉藤 貴志, 西道 隆臣, 山中 宏二

第1回脳科学サロン  2020.8.15 

Microglial cannabinoid receptor type II as potential therapeutic target for Alzheimer's disease.

Sobue A, Komine O, Endo F, Shigeo Murayama S, Saito T, Saido TC, Yamanaka K.

アルツハイマー病患者とAppNL-G-F マウスにおける神経炎症関連遺伝⼦解析

祖父江　顕、小峯　起、遠藤史人、村山繁雄、斉藤貴志、西道隆臣、山中宏二

第38回日本認知症学会学術集会 

アルツハイマー病患者脳とAPP- KIマウス由来ミクログリアにおける遺伝子発現解析

祖父江　顕、小峯　起、遠藤史人、村山繁雄、斉藤貴志、西道 隆臣、山中宏二

第42回日本神経科学大会第62回日本神経化学会大会 

Profiling of gene expression in Alzheimer's disease patients and APP-KI mouse model demonstrates a link between amyloid pathology and microglial phenotype

Akira Sobue, Okiru Komine, Fumito Endo, Shigeo Murayama, Koji Yamanaka

早期アルツハイマー病理を呈する患者脳における神経炎症関連遺伝子発現解析

祖父江顕、遠藤史人、小峯起、村山繁雄、山中宏二

第37回日本認知症学会学術集会 

The pathophysiological role of astroglial MHCI following systemic immune activation

Akira Sobue, Norimichi Ito, Kazuhiro Hada, Akira Nakajima, Murakami Yuki, Mouri akihiro, Yamamoto Yasuko, Toshitaka Nabeshima, Kuniaki Saito, Taku Nagai, Kiyofumi Yamada

The pathophysiological role of astroglial MHCI following immune activation

Akira Sobue, Norimichi Ito, Wei Shan, Kazuhiro Hada, Akira Nakajima, Yuki Murakami, Akihiro Mouri, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito, Taku Nagai, Kiyofumi Yamada

Astroglial MHCI following immune activation leads to behavioral and neuropathological abnormalities

Akira Sobue, Norimichi Ito, Wei Shan, Kazuhiro Hada, Akira Nakajima, Yuki Murakami, Akihiro Mouri, Yasuko Yamamoto, Toshitaka Nabeshima, Kuniaki Saito, Taku Nagai, Kiyofumi Yamada

Astroglial MHCI expression and its behavioral and neuropathological implications

Peripheral immune activation leads to the expression of MHCI molecules in the cortex of mice.

末梢免疫活性が及ぼすマウス大脳皮質における免疫関連因子の発現誘導

祖父江 顕, 伊藤 教道, 羽田 和弘, 中島 晶, 村上 由希, 毛利 彰宏, 山本 康子, 鍋島俊隆, 齋藤 邦明, 永井 拓, 山田 清文

第 131 回日本薬理学会近畿部会  

Exosomal MHCI derived from astrocytes leads to behavioral and neuropathological abnormalities in mice International conference

Akira Sobue, Norimichi Ito, Kazuhiro Hada, Akira Nakajima, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

International Behavioral Neuroscience Society for the 26th Annual Meeting 

Behavioral and neurochemical abnormalities in MHCI-expressed mice International conference

Akira Sobue, Norimichi Ito, Kazuhiro Hada, Akira Nakajima, Toshitaka Nabeshima, Taku Nagai, Kiyofumi Yamada

The 5th Congress of Asian College of Neuropsychopharmacology 

Behavioral alterations accompanied by neuropathological changes induced by the expression of MHCI in the prefrontal cortex of mice

Expression of MHCI in astrocyte leads to behavioral and neuropathological abnormalities

Reln rl-Orl/+ mice show behavioral abnormalities in emotion, social interaction and motor learning: association with dopaminergic dysfunction International conference

Akira Sobue, Yuki Aoyama, Shan Wei, Taku Nagai, Kiyofumi Yamada

Dopamine 2016 

アストロサイトにおける MHC Class I の発現が行動に及ぼす影響と神経科学的解析

祖父江顕、伊藤教道、羽田和弘、中島晶、永井拓、鍋島俊隆、山田清文

第 18 回応用薬理シンポジウム 

アストロサイトにおける MHCI の発現が社会性行動および認知機能へ及ぼす影響

祖父江顕、伊藤教道、羽田和弘、中島晶、永井拓、鍋島俊隆、山田清文

第 89 回日本薬理学会年会 

統合失調症モデルマウスとしての Orleans reeler マウスの行動評価と神経科学的解析

祖父江顕、青山雄紀、Wei Shan、永井拓、山田清文

第 25 回神経行動薬理若手研究者の集い  

Expression of MHC class I gene in astrocytes impaires social behavior, cognitive function and sensorimotor gating in mice

アストロサイトにおける MHC Class I の過剰発現が行動に及ぼす影響

祖父江顕、伊藤教道、中島晶、永井拓、山田清文

第 128 回日本薬理学会近畿部会  

中枢神経系における MHC Class I の細胞内局在と分泌機構について

祖父江顕、伊藤教道、中島晶、永井拓、山田清文

第 88 回日本薬理学会年 

The localization and secretion of MHC class I molecules in neuronal and glial cells

認知症治療薬による錐体外路障害に対するセロトニン作用薬の評価

祖父江顕、清水佐紀、水口裕登、藤原麻衣、森本朋樹、大野行弘

第 63 回日本薬学会近畿支部総会・大会 

認知症治療薬による錐体外路障害助長に対するセロトニン神経作用薬の影響

祖父江顕、清水佐紀、水口裕登、藤原麻衣、森本朋樹、大野行弘

生体機能と創薬シンポジウム 2013 

基盤医科学実習

2019

基盤医科学実習

2018