Updated on 2021/03/31

写真a

 
MATSUYAMA Shuichi
 
Organization
Graduate School of Bioagricultural Sciences Field Science Center Division Associate professor
Title
Associate professor

Degree 1

  1. 博士(農学) ( 2005.6   名古屋大学 ) 

Research Interests 3

  1. 繁殖

  2. 神経内分泌

  3. 子宮

Research Areas 3

  1. Life Science / Animal production science

  2. Life Science / Animal production science

  3. Life Science / Animal production science

Current Research Project and SDGs 1

  1. 牛の低受胎要因解明と生産性向上技術の開発

Professional Memberships 3

  1. 日本繁殖生物学会

  2. 日本畜産学会

  3. Society for the Study of Reproduction

Committee Memberships 6

  1. 公益社団法人 日本繁殖生物学会   評議員  

    2019.9 - 2021.8   

  2. 公益社団法人 日本繁殖生物学会   将来計画検討委員  

    2019.9 - 2021.8   

  3. 公益社団法人 日本繁殖生物学会   庶務幹事  

    2019.9 - 2021.8   

  4. 公益社団法人 日本繁殖生物学会   広報委員  

    2019.9 - 2021.8   

  5. 畜産学教育協議会   幹事  

    2019.4 - 2021.3   

  6. 東海畜産学会   評議員  

    2019.4 - 2021.3   

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Awards 2

  1. NARO RESEARCH PRIZE

    2016.9  

  2. 第94回日本繁殖生物学会大会 優秀ポスター賞

    2001.9  

    松山秀一

 

Papers 48

  1. Neurokinin 3 receptor-selective agonist, senktide, decreases core temperature in Japanese Black cattle Reviewed

    Nakamura S., Miwa M., Morita Y., Ohkura S., Yamamura T., Wakabayashi Y., Matsuyama S.

    DOMESTIC ANIMAL ENDOCRINOLOGY   Vol. 74   2021.1

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Domestic Animal Endocrinology  

    DOI: 10.1016/j.domaniend.2020.106522

  2. Seasonal changes in the reproductive performance in local cows receiving artificial insemination in the Pursat province of Cambodia Reviewed

    Tep Bengthay, Morita Yasuhiro, Matsuyama Shuichi, Ohkura Satoshi, Inoue Naoko, Tsukamura Hiroko, Uenoyama Yoshihisa, Pheng Vutha

    ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES   Vol. 33 ( 12 ) page: 1922 - 1929   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Asian-Australasian Journal of Animal Sciences  

    DOI: 10.5713/ajas.19.0893

  3. Facilitatory and inhibitory role of central amylin administration in the regulation of the gonadotropin-releasing hormone pulse generator activity in goats Reviewed

    Kitagawa Yuri, Sasaki Takuya, Suzumura Reika, Morishima Ai, Tatebayashi Ryoki, Assadullah, Ieda Nahoko, Morita Yasuhiro, Matsuyama Shuichi, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko, Ohkura Satoshi

    NEUROSCIENCE LETTERS   Vol. 736   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Neuroscience Letters  

    DOI: 10.1016/j.neulet.2020.135276

  4. Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats Reviewed

    Sasaki Takuya, Sonoda Tomoya, Tatebayashi Ryoki, Kitagawa Yuri, Oishi Shinya, Yamamoto Koki, Fujii Nobutaka, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko, Maeda Kei-ichiro, Matsuda Fuko, Morita Yasuhiro, Matsuyama Shuichi, Ohkura Satoshi

    JOURNAL OF REPRODUCTION AND DEVELOPMENT   Vol. 66 ( 4 ) page: 351 - 357   2020.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  5. Establishment of immortalised cell lines derived from female Shiba goat KNDy and GnRH neurones Reviewed

    Suetomi Yuta, Tatebayashi Ryoki, Sonoda Shuhei, Munetomo Arisa, Matsuyama Shuichi, Inoue Naoko, Uenoyama Yoshihisa, Takeuchi Yukari, Tsukamura Hiroko, Ohkura Satoshi, Matsuda Fuko

    JOURNAL OF NEUROENDOCRINOLOGY   Vol. 32 ( 6 )   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Neuroendocrinology  

    DOI: 10.1111/jne.12857

  6. Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats Reviewed

    Sasaki Takuya, Sonoda Tomoya, Tatebayashi Ryoki, Kitagawa Yuri, Oishi Shinya, Yamamoto Koki, Fujii Nobutaka, Inoue Naoko, Uenoyama Yoshihisa, Tsukamura Hiroko, Maeda Kei-ichiro, Matsuda Fuko, Morita Yasuhiro, Matsuyama Shuichi, Ohkura Satoshi

    JOURNAL OF REPRODUCTION AND DEVELOPMENT   Vol. 66 ( 3 ) page: 351 - 357   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

  7. Colocalization of GPR120 and anterior pituitary hormone-producing cells in female Japanese Black cattle Reviewed

    Nakamura Sho, Noda Kohei, Miwa Masafumi, Minabe Shiori, Hagiwara Teruki, Hirasawa Akira, Matsuyama Shuichi, Moriyama Ryutaro

    JOURNAL OF REPRODUCTION AND DEVELOPMENT   Vol. 66 ( 2 ) page: 135 - 141   2020.4

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  8. Colocalization of GPR120 and anterior pituitary hormone-producing cells in female Japanese Black cattle Reviewed

    Nakamura S.

    Journal of Reproduction and Development   Vol. 66 ( 2 ) page: 135 - 141   2020

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Reproduction and Development  

    DOI: 10.1262/jrd.2019-111

  9. Peripheral administration of sb223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats Reviewed

    Sasaki T.

    Journal of Reproduction and Development   Vol. 66 ( 4 ) page: 351 - 357   2020

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Reproduction and Development  

    DOI: 10.1262/jrd.2019-145

  10. Establishment of long-term chronic recording technique of in vivo ovarian parenchymal temperature in Japanese black cows Reviewed

    Morita Y.Ozaki R, Mukaiyama A, Sasaki T, Tatebayashi R, Morishima A, Kitagawa Y, Suzumura R, Abe R, Tsukamura H, Matsuyama S, Ohkura S.

    Journal of Reproduction and Development   Vol. 66 ( 3 ) page: 271 - 275   2020

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Reproduction and Development  

    DOI: 10.1262/jrd.2019-097

  11. Prepartum change in ventral tail base surface temperature in beef cattle: comparison with vaginal temperature and behavior indices, and effect of ambient temperature Reviewed

    Miwa Masafumi, Matsuyama Shuichi, Nakamura Sho, Noda Kohei, Sakatani Miki

    JOURNAL OF REPRODUCTION AND DEVELOPMENT   Vol. 65 ( 6 ) page: 515 - 525   2019.12

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  12. Characterisation of bovine embryos following prolonged culture in embryonic stem cell medium containing leukaemia inhibitory factor Reviewed

    Hosoe Misa, Furusawa Tadashi, Hayashi Ken-Go, Takahashi Toru, Hashiyada Yutaka, Kizaki Keiichiro, Hashizume Kazuyoshi, Tokunaga Tomoyuki, Matsuyama Shuichi, Sakumoto Ryosuke

    REPRODUCTION FERTILITY AND DEVELOPMENT   Vol. 31 ( 6 ) page: 1157 - 1165   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Reproduction, Fertility and Development  

    DOI: 10.1071/RD18343

  13. Age-related changes in the bovine corpus luteum function and progesterone secretion. Reviewed

    Hori K, Matsuyama S, Nakamura S, Iwata H, Kuwayama T, Miyamoto A, Shirasuna K

    Reproduction in domestic animals = Zuchthygiene   Vol. 54 ( 1 ) page: 23 - 30   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/rda.13303

  14. Prepartum change in ventral tail base surface temperature in beef cattle: Comparison with vaginal temperature and behavior indices, and effect of ambient temperature Reviewed

    Miwa M.

    Journal of Reproduction and Development   Vol. 65 ( 6 ) page: 515 - 525   2019

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Reproduction and Development  

    DOI: 10.1262/jrd.2019-087

  15. Propionate and butyrate induce gene expression of monocarboxylate transporter 4 and cluster of differentiation 147 in cultured rumen epithelial cells derived from preweaning dairy calves Reviewed

    Nakamura Sho, Haga Satoshi, Kimura Koji, Matsuyama Shuichi

    JOURNAL OF ANIMAL SCIENCE   Vol. 96 ( 11 ) page: 4902 - 4911   2018.11

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jas/sky334

  16. Publisher Correction: Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle. Reviewed

    Ikeda M, Matsuyama S, Akagi S, Ohkoshi K, Nakamura S, Minabe S, Kimura K, Hosoe M

    Scientific reports   Vol. 8 ( 1 ) page: 1470   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-19725-z

  17. Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle. Reviewed

    Ikeda M, Matsuyama S, Akagi S, Ohkoshi K, Nakamura S, Minabe S, Kimura K, Hosoe M

    Scientific reports   Vol. 7 ( 1 ) page: 17827   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-17968-w

  18. Production of calves by the transfer of cryopreserved bovine elongating conceptuses and possible application for preimplantation genomic selection. Reviewed

    Fujii T, Hirayama H, Naito A, Kashima M, Sakai H, Fukuda S, Yoshino H, Moriyasu S, Kageyama S, Sugimoto Y, Matsuyama S, Hayakawa H, Kimura K

    The Journal of reproduction and development   Vol. 63 ( 5 ) page: 497-504   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1262/jrd.2017-025

  19. Interferon Tau Regulates Cytokine Production and Cellular Function in Human Trophoblast Cell Line. Reviewed

    Tanikawa N, Seno K, Kawahara-Miki R, Kimura K, Matsuyama S, Iwata H, Kuwayama T, Shirasuna K

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research   Vol. 37 ( 10 ) page: 456-466   2017.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/jir.2017.0057

  20. Age-associated mRNA expression changes in bovine endometrial cells in vitro. Reviewed

    Tanikawa N, Ohtsu A, Kawahara-Miki R, Kimura K, Matsuyama S, Iwata H, Kuwayama T, Shirasuna K

    Reproductive biology and endocrinology : RB&E   Vol. 15 ( 1 ) page: 63   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12958-017-0284-z

  21. A neurokinin 3 receptor-selective agonist accelerates pulsatile luteinizing hormone secretion in lactating cattle Reviewed

    Nakamura Sho, Wakabayashi Yoshihiro, Yamamura Takashi, Ohkura Satoshi, Matsuyama Shuichi

    BIOLOGY OF REPRODUCTION   Vol. 97 ( 1 ) page: 81 - 90   2017.7

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/biolre/iox068

  22. ウシの子宮機能と受胎性について Reviewed

    木村康二、松山秀一

    家畜感染症学会誌   Vol. 5 ( 4 ) page: 145 - 151   2016.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  23. Derivation of Induced Trophoblast Cell Lines in Cattle by Doxycycline-Inducible piggyBac Vectors Reviewed

    Kawaguchi T, Cho D, Hayashi M, Tsukiyama T, Kimura K, Matsuyama S, Minami N, Yamada M, Imai H.

    PLoS ONE   Vol. 11 ( 12 ) page: e0167550   2016.11

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  24. Immunohistochemical characterization of the arcuate kisspeptin/neurokinin B/dynorphin (KNDy) and preoptic kisspeptin neuronal populations in the hypothalamus during the estrous cycle in heifers. Reviewed

    Hassaneen A, Naniwa Y, Suetomi Y, Matsuyama S, Kimura K, Ieda N, Inoue N, Uenoyama Y, Tsukamura H, Maeda K, Matsuda F, Ohkura S.

    Journal of Reproduction and Development   Vol. 62 ( 5 ) page: 471 - 477   2016.10

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  25. ウシにおける胚の生存性と子宮環境 Reviewed

    松山秀一、中村翔、木村康二

    日本胚移植学雑誌   Vol. 38 ( 3 ) page: 115 - 121   2016.9

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  26. Possible role of IFNT on the bovine corpus luteum and neutrophils during the early pregnancy. Reviewed

    Shirasuna K, Matsumoto H, Matsuyama S, Kimura K, Bollwein H, Miyamoto A.

    Reproduction   Vol. 150 ( 3 ) page: 217 - 225   2015.9

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  27. Generation of Naive Bovine Induced Pluripotent Stem Cells Using PiggyBac Transposition of Doxycycline-Inducible Transcription Factors. Reviewed

    Kawaguchi T, Tsukiyama T, Kimura K, Matsuyama S, Minami N, Yamada M, Imai H.

    PLoS ONE   Vol. 10 ( 8 ) page: e0135403   2015.8

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  28. Interferon-tau attenuates uptake of nanoparticles and secretion of interleukin-1β in macrophages. Reviewed

    Hara K, Shirasuna K, Usui F, Karasawa T, Mizushina Y, Kimura H, Kawashima A, Ohkuchi A, Matsuyama S, Kimura K, Takahashi M.

    PLoS ONE   Vol. 9 ( 12 ) page: e113974   2014.12

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  29. Regulation of gonadotropin secretion by monitoring energy availability. Reviewed

    Matsuyama S, Kimura K

    Reproductive Medicine and Biology   Vol. 14 ( 2 ) page: 39 - 47   2014.9

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  30. Successful nonsurgical transfer of bovine elongating conceptuses and its application to sexing. Reviewed

    Kimura K Matsuyama S.

    Journal of Reproduction and Development   Vol. 60 ( 3 ) page: 210 - 215   2014.7

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  31. Aerococcus vaginalis sp. nov., isolated from the vaginal mucosa of a beef cow, and emended descriptions of Aerococcus suis, Aerococcus viridans, Aerococcus urinaeequi, Aerococcus urinaehominis, Aerococcus urinae, Aerococcus christensenii and Aerococcus sanguinicola. Reviewed

    Tohno M, Kitahara M, Matsuyama S, Kimura K, Ohkura M, Tajima K.

    International Journal of Systematic and Evolutionary Microbiology   Vol. 64   page: 1229 - 1236   2014.4

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  32. 末梢単核球を利用したウシ胚の生存性モニタリング-妊娠早期における胚死滅のメカニズム解明に向けて- Reviewed

    松山秀一、木村康二

    日本胚移植学雑誌   Vol. 35 ( 3 ) page: 123 - 127   2013.9

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  33. Characteristics of bovine inner cell mass-derived cell lines and their fate in chimeric conceptuses. Reviewed

    Furusawa T, Ohkoshi K, Kimura K, Matsuyama S, Akagi S, Kaneda M, Ikeda M, Hosoe M, Kizaki K, Tokunaga T.

    Biology of Reproduction   Vol. 89 ( 2 ) page: 1 - 12   2013.8

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  34. Sexual dimorphism during early embryonic development in mammals. Reviewed

    Kimura K, Matsuyama S.

    J. Mamm. Ova Res.   Vol. 29   page: 103 - 112   2012.11

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  35. Relationship between plasma progesterone concentration and number of conceptuses and their growth in superovulated cattle. Reviewed

    Matsuyama S, Sakaguchi Y, Kimura K.

    Journal of Reproduction and Development   Vol. 58 ( 5 ) page: 609 - 614   2012.11

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  36. Relationship between quantity of IFNT estimated by IFN-stimulated gene expression in peripheral blood mononuclear cells and bovine embryonic mortality after AI or ET. Reviewed

    Matsuyama S, Kojima T, Kato S, Kimura K.

    Reproductive Biology and Endocrinology   Vol. 10   page: 21   2012.3

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  37. Possible involvement of IFNT in lymphangiogenesis in the corpus luteum during the maternal recognition period in the cow. Reviewed

    Nitta A, Shirasuna K, Haneda S, Matsui M, Shimizu T, Matsuyama S, Kimura K, Bollwein H, Miyamoto A.

    Reproduction   Vol. 142 ( 6 ) page: 79 - 92   2011.12

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  38. Morphological Evidence for Direct Interaction between Kisspeptin and Gonadotropin-Releasing Hormone Neurons at the Median Eminence of the Male Goat: An Immunoelectron Microscopic Study. Reviewed

    Matsuyama S, Ohkura S, Mogi K, Wakabayashi Y, Mori Y, Tsukamura H, Maeda K, Ichikawa M, Okamura H.

    Neuroendocrinology   Vol. 94 ( 4 ) page: 323 - 332   2011.11

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  39. Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat. Reviewed

    Ohkura S, Takase K, Matsuyama S, Mogi K, Ichimaru T, Wakabayashi Y, Uenoyama Y, Mori Y, Steiner RA, Tsukamura H, Maeda K, Okamura H.

    Journal of Neuroendocrinology   Vol. 21 ( 10 ) page: 813 - 821   2009.10

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  40. Food deprivation induces monocarboxylate transporter 2 expression in the brainstem in female rat. Reviewed

    Matsuyama S, Ohkura S, Iwata K, Uenoyama Y, Tsukamura H, Maeda K, Kimura K.

    Journal of Reproduction and Development   Vol. 55 ( 3 ) page: 256 - 261   2009.7

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  41. Central Administration of Neuropeptide B, but not Prolactin-Releasing Peptide, Stimulates Cortisol Secretion in Sheep. Reviewed

    Mogi K, Ito S, Matsuyama S, Ohara H, Sakumoto R, Yayo K , Ohkura S, Sutoh M、Mori Y, Okamura H.

    Journal of Reproduction and Development   Vol. 54 ( 2 ) page: 138 - 141   2008.4

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  42. 既知個体および自身の映像がホルスタイン種去勢牛の隔離ストレス反応に及ぼす影響 Reviewed

    伊藤秀一、矢用健一、松山秀一、森山隆太郎、須藤まどか、粕谷悦子、大蔵聡、岡村裕昭

    応用動物行動学会報(Animal Behaviour and Management)   Vol. 42 ( 4 ) page: 203 - 208   2006.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  43. Acute lipoprivation suppresses pulsatile luteinizing hormone secretion without affecting food intake in female rats. Reviewed

    Shahab M, Sajapitak S, Tsukamura H, Kinoshita M, Matsuyama S, Ohkura S, Yamada S, Uenoyama Y, I’Anson H, Maeda K

    Journal of Reproduction and Development   Vol. 52 ( 6 ) page: 763 - 772   2006.12

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  44. Activation of melanocortin receptors accelerates the gonadotropin-releasing hormone pulse generator activity in goats. Reviewed

    Matsuyama S, Ohkura S, Sakurai K, Tsukamura H, Maeda K, Okamura H.

    Neuroscience Letters   Vol. 383 ( 3 ) page: 289 - 294   2005.8

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  45. Simultaneous observation of the GnRH pulse generator activity and plasma concentrations of metabolites and insulin during fasting and subsequent refeeding periods in Shiba goats. Reviewed

    Matsuyama S, Ohkura S, Ichimaru T, Sakurai K, Tsukamura H, Maeda K, Okamura H.

    Journal of Reproduction and Development   Vol. 50 ( 6 ) page: 697 - 704   2005.1

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  46. Further evidence for the role of glucose as a metabolic regulator of hypothalamic gonadotropin-releasing hormone pulse generator activity in goats. Reviewed

    Ohkura S, Ichimaru T, Ito F, Matsuyama S, Okamura H.

    Endocrinology   Vol. 145 ( 7 ) page: 3239 - 3246   2004.7

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  47. Body growth and plasma concentrations of metabolites and metabolic hormones during the pubertal period in female Shiba goats. Reviewed

    Sakurai K, Ohkura S, Matsuyama S, Kato K, Obara Y, Okamura H.

    Journal of Reproduction and Development   Vol. 50 ( 2 ) page: 197 - 205   2004.4

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  48. Central cholecystokinin-octapeptide accelerates the activity of the hypothalamic gonadotropin-releasing hormone pulse generator in goats. Reviewed

    Ichimaru T, Matsuyama S, Ohkura S, Mori Y, Okamura H.

    Journal of Neuroendocrinology   Vol. 15 ( 1 ) page: 80 - 86   2003.1

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Presentations 29

  1. ウシ過剰排卵処置時におけるニューロキニンB受容体作動薬の静脈内投与が回収胚の発育ステージおよび遺伝子発現に及ぼす影響

    松山秀一、中村 翔、美辺詩織、大石真也、大蔵 聡、木村康二

    日本受精卵移植関連合同研究会東京大会 第32回東日本家畜受精卵移植技術研究会大会、第23回日本胚移植研究会大会  2016.9 

  2. 泌乳期ウシにおけるニューロキニンB受容体作動薬が黄体形成ホルモンのパルス状分泌に及ぼす影響

    中村 翔、若林嘉浩、山村 崇、大蔵 聡、松山秀一

    日本下垂体研究会  2017.8 

  3. ウシ子宮内膜side population(SP)細胞の遺伝子発現解析と分娩後におけるSP細胞割合の推移

    舘林 亮輝, 中村 翔, 美辺 詩織, 古澤 軌, 阿部 良哉, 加治佐 実希, 森田 康広, 大蔵 聡, 木村 康二, 松山 秀一

    第113回日本繁殖生物学会大会  2020.9 

  4. メチルグリオキサールがウシ子宮内膜細胞に及ぼす影響

    阿部 良哉, 舘林 亮輝, 加治佐 実希, 森田 康広, 大蔵 聡, 松山 秀一

    第113回日本繁殖生物学会大会  2020.9 

  5. 分娩後のウシ子宮内膜における老化細胞の蓄積レベルの変化

    加治佐 実希, 舘林 亮輝, 阿部 良哉, 森田 康広, 大蔵 聡, 松山 秀一

    第113回日本繁殖生物学会大会  2020.9 

  6. 暑熱ストレス下におけるウシの排卵不全メカニズムの解明

    向山 晃永, 館林 亮輝, 北川 悠梨, 阿部 良哉, 鈴村 玲香, 松山 秀一, 大蔵 聡, 森田 康広

    第113回日本繁殖生物学会大会  2020.9 

  7. シバヤギにおけるGnRHパルス発生中枢の制御に関わるセロトニン受容体サブタイプの検討

    鈴村 玲香, 森田 康広, 松山 秀一, 佐々木 拓弥, 北川 悠梨, 井上 直子, 上野山 賀久, 束村 博子, 大蔵 聡

    第113回日本繁殖生物学会大会  2020.9 

  8. ニューロキニンB受容体作動薬投与が夏季のウシ体温に及ぼす影響

    中村翔, 三輪雅史, 森田康広, 山村崇, 若林嘉浩, 大蔵聡, 松山秀一

    第112回日本繁殖生物学会大会  2019.9 

  9. 低受胎牛の子宮環境と改善技術 Invited

    松山秀一

    第3回日本胚移植技術研究会和歌山大会 シンポジウム「畜産領域におけるリキッドバイオプシーの展開」  2019.8 

  10. Understanding the uterine environment in subfertile cattle Invited

    MATSUYAMA S, NAKAMURA S, OHKURA S, KIMURA K

    2019.9 

  11. ウシ子宮内膜Side population細胞における幹細胞マーカーの発現解析

    館林亮輝、中村翔、美辺詩織、古澤軌、阿部良哉、森田康広、大蔵聡、木村康二、松山秀一

    第112回日本繁殖生物学会大会  2019.9 

  12. パルス状GnRH分泌制御機構におけるカルシトニン受容体の役割

    北川 悠梨, 佐々木 拓弥, 森島 愛, 舘林 亮輝, 森田 康広, 松山 秀一, 井上 直子, 上野山 賀久, 束村 博子, 大蔵 聡

    第112回日本繁殖生物学会大会  2019.9 

  13. シバヤギのパルス状GnRH分泌制御メカニズムにおけるセロトニンの役割

    佐々木 拓弥, 森島 愛, 中西 真莉菜, 鈴村 玲香, 舘林 亮輝, 北川 悠梨, 森田 康広, 松山 秀一, 井上 直子, 上野山 賀久, 束村 博子, 大蔵 聡

    第112回日本繁殖生物学会大会  2019.9 

  14. 長鎖脂肪酸への曝露がウシおよびブタ精子の運動性に与える影響

    森山 隆太郎, 平井 直明, 野田 航平, 山口 直哉, 三輪 雅史, 中村 翔, 松山 秀一

    第111回日本繁殖生物学会大会  2018.9 

  15. 体表温センサによる肉用繁殖牛の分娩時刻予知の検討

    三輪 雅史, 中村 翔, 松山 秀一

    第111回日本繁殖生物学会大会  2018.9 

  16. ニューロキニンB受容体拮抗剤の経口投与はパルス状LH分泌を抑制する

    佐々木 拓弥, 園田 朋也, 大石 真也, 藤井 信孝, 森田 康広, 松山 秀一, 井上 直子, 上野山 賀久, 束村 博子, 前多 敬一郎, 松田 二子, 大蔵 聡

    第111回日本繁殖生物学会大会  2018.9 

  17. ニューロキニン作動薬の持続投与がウシの性腺刺激ホルモン分泌に及ぼす影響

    山村 崇, 松山 秀一, 中村 翔, 遠藤 なつ美, 田中 知己, 若林 嘉浩

    第111回日本繁殖生物学会大会  2018.9 

  18. ニューロキニンB受容体作動薬投与がウシの体温に及ぼす影響

    中村 翔, 三輪 雅史, 山村 崇, 若林 嘉浩, 松山 秀一

    第111回日本繁殖生物学会大会  2018.9 

  19. Effect of aging on the corpus luteum function in beef and dairy cows

    Konomi Hori, Shuichi Matsuyama, Sho Nakamura, Aoba Naito, Mayumi Matsushita, Wakana Arihara, Haruka Kawahara, Takehito Kuwayama, Hisataka Iwata, Akio Miyamoto and Koumei Shirasuna

    2017.9 

  20. Inflammation, interferon signaling, and cell cycle-related genes are changed with aging in bovine endometrial cells

    Nao Tanikawa, Ayaka Ohtsu, Ryoka Kawahara-Miki, Koji Kimura, Shuichi Matsuyama, Hisataka Iwata, Takehito Kuwayama and Koumei Shirasuna

    2017.9 

  21. Mitochondrial malfunction in the endometrium of subfertile cattle

    Shuichi Matsuyama, Sho Nakamura, Shiori Minabe and Koji Kimura

    2017.9 

  22. Establishment of immortalized GnRH neuronal cell lines derived from the cattle brain

    Riho OZAKI, Yoshihisa Uenoyama, Yuta Suetomi, Shuichi Matsuyama, Koji Kimura, Nahoko Ieda, Naoko Inoue, Hiroko Tsukamura, Satoshi Ohkura and Fuko Matsuda

    2017.9 

  23. A Neurokinin 3 Receptor-Selective Agonist, Senktide, Stimulates Pulsatile Luteinizing Hormone Secretion in Lactating Cattle

    Sho Nakamura, Yoshihiro Wakabayashi, Takashi Yamamura, Satoshi Ohkura and Shuichi Matsuyama

    2017.9 

  24. 分娩後のウシ子宮内膜におけるSide population細胞の発現挙動

    松山 秀一, 美辺 詩織, 中村 翔, 古澤 軌, 池田 光美, 木村 康二

    第110回日本繁殖生物学会大会  2016.9 

  25. ウシ伸長胚を用いた着床前ゲノム選抜技術開発に向けたSNP解析精度の検討

    平山 博樹, 内藤 学, 鹿島 聖志, 藤井 貴志, 陰山 聡一, 坂井 ひとみ, 杉本 喜憲, 松山 秀一, 木村 康二, 早川 宏之, 森安 悟

    第110回日本繁殖生物学会大会  2016.9 

  26. 着床前ゲノム選抜技術開発に向けたウシ伸長胚保存法の検討

    藤井 貴志, 平山 博樹, 陰山 聡一, 内藤 学, 福田 茂夫, 吉野 仁美, 松山 秀一, 木村 康二, 早川 宏之, 津田 栄, 森安 悟

    第110回日本繁殖生物学会大会  2016.9 

  27. ウシ過剰排卵処置時におけるニューロキニンB受容体作動薬の末梢投与が黄体形成ホルモン分泌および回収胚の品質に及ぼす影響

    中村 翔, 木村 康二, 美辺 詩織, 大石 真也, 大蔵 聡, 松山 秀一

    第110回日本繁殖生物学会大会  2016.9 

  28. ニューロキニンB受容体作動薬投与が泌乳期ウシの分娩後初回排卵へ及ぼす影響

    中村 翔、若林嘉浩、山村 崇、大蔵 聡、松山秀一

    日本受精卵移植関連合同研究会京都大会(第24回日本胚移植研究会大会、第33回東日本家畜受精卵移植技術研究会大会)  2017.9 

  29. ウシ子宮内膜におけるミトコンドリア機能の亢進は受胎率を飛躍的に向上させる

    松山秀一、中村 翔、美辺詩織、岩田尚孝、木村康二

    日本受精卵移植関連合同研究会京都大会(第24回日本胚移植研究会大会、第33回東日本家畜受精卵移植技術研究会大会)  2017.9 

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Research Project for Joint Research, Competitive Funding, etc. 5

  1. レスベラトロール子宮内投与による人工授精受胎率向上技術の開発

    2019.09 - 2020.03

    大垣共立銀行  第6回 OKBアグリビジネス助成金 

    松山秀一

  2. AIを活用した家畜疾病の早期発見技術の開発

    2017.04

    農林水産省  革新的技術開発・緊急展開事業(うち人工知能未来創造プロジェクト) 

    松山秀一

  3. ゲノム編集による家畜系統造成の加速化

    2015.04 - 2018.03

    農林水産省  農林水産業・食品産業科学技術研究推進事業 

    松山秀一

  4. 生体センシング技術を活用した次世代精密家畜個体管理システムの開発

    2014.04 - 2017.03

    内閣府  戦略的イノベーション創造プログラム(次世代農林水産業創造技術) 

    松山秀一

  5. 繁殖サイクルの短縮や受胎率向上のための技術開発

    2012.04 - 2017.03

    農林水産省  委託プロジェクト研究 

    松山秀一

KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. Development of technique to decrease voluntary waiting period of cattle using ozone gel

    Grant number:20K21372  2020.07 - 2022.03

    Grant-in-Aid for Challenging Research (Exploratory)

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    Authorship:Coinvestigator(s) 

  2. 最終糖化産物がウシ子宮、卵管および胚発育に及ぼす影響とその作用機序の解明

    Grant number:20H03129  2020.04 - 2024.03

    松山 秀一

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    Authorship:Principal investigator 

    Grant amount:\17680000 ( Direct Cost: \13600000 、 Indirect Cost:\4080000 )

    分娩後の乳牛では、泌乳にともなう負のエネルギーバランスを補うように設計された穀物主体の飼料が給与されているが、受胎率は低下の一途を辿っている。本研究では、高穀物含量の飼料によって産生されるメチルグリオキサールが受胎率低下の一因となっていることを検証する。ウシ生体を用いて、血中メチルグリオキサール濃度の上昇が受胎性に及ぼす影響を明らかにし、次いで、ウシ子宮内膜細胞、卵管細胞、卵子および胚を用いて、メチルグリオキサールが低受胎を引き起こすメカニズムを解明する。

  3. ATP-プリン受容体シグナリングによる哺乳類の排卵中枢制御メカニズムの解明

    Grant number:19H03103  2019.04 - 2023.03

    井上 直子

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    Authorship:Coinvestigator(s) 

    本研究の目的は、ほ乳類の雌の排卵を制御する視床下部視索前野/前腹側室周囲核キスペプチンニューロンに発現するプリン受容体に着目し、ATP-プリン受容体シグナリングが排卵中枢であるキスペプチンニューロンを活性化し排卵に至る神経メカニズムを明らかにすることである。一般的に細胞内のエネルギー通貨として知られるATPは、脳内でプリン作動性神経リガンドとして作用するが生殖機能における役割は不明であった。本研究では、ATP-プリン受容体による排卵中枢キスペプチンニューロンの活性化メカニズムを明らかにするとともに、得られた知見の家畜への応用を検証する。

  4. In vitro construction of bovine endometrium including uterine glands and the study on the machanisms of bovine conceptus development

    Grant number:19H03105  2019.04 - 2023.03

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    Authorship:Coinvestigator(s) 

  5. Elucidation of endometrial regeneration mechanism by mesenchymal epithelial conversion of bovine endometrial stromal SP cells

    Grant number:17K08141  2017.04 - 2020.03

    Grant-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research(C)

    Matsuyama Shuichi

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    Authorship:Principal investigator 

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    In this study, the RNA-seq analysis of side population (SP) cell identified in bovine endometrium revealed that SP cells have stem/progenitor cell-like properties, and some of them might be derived from bone marrow. The ratio of SP cells in endometrial cells were low immediately after parturition and then gradually increased, suggesting that SP cells are differentiated and proliferated into endometrial cells after parturition. Besides, the ratio of endometrial SP cells in low fertility cows with a high number of calving was similar to that in normal fertility cows with a low number of calving. From this result, it is possible that the ratio of SP cells is not affected by parity, and the number of SP cells is unlikely to affect fertility in cows.

  6. ウシ子宮内膜再生メカニズムの解明

    Grant number:15K18806  2015.04 - 2017.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

  7. Establishment and evaluation of bovine induced trophoblast cell line and contruction of in vitro implantation model using this cell line.

    Grant number:26292168  2014.04 - 2018.03

    Kimura Koji

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    Authorship:Coinvestigator(s) 

    It is necessary for improvement of pregnancy rate in cattle to clarify the mechanisms involved in its embryo development, implantation and establishment of pregnancy. The aims of the present study are to establish the bovine induced pluripotent stem cell and induced trophoblastic cells. Bovine amnion derived cells (bADC) were introduced with transposone expression vectors (piggyBac vectors) containing doxycycline (Dox)-inducible transcription factors. Colonies were selected by morphology criteria and then their characteristics were evaluated by expression of stem cell or trophectoderm markers. We established both of bovine iPS cell lines which can be differentiated to germ cells in vivo and trophoblast cell lines which processed trophoblast stem cell-like characteristics and the potential to differentiate into the extra-embryonic cell lineage.

  8. 子宮内膜再生に寄与するウシ子宮内膜幹細胞の同定

    Grant number:25850225  2013.04 - 2015.03

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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Industrial property rights 3

  1. 受胎性促進剤

    松山秀一、木村康二

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    Application no:特願2016-207865 

  2. 牛の過排卵誘起用皮下注射剤

    木村康二、松山秀一、石井健容、関誠、濱田俊哉

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    Application no:PCT/JP2014/063672 

  3. 牛の過排卵誘起用皮下注射剤

    木村康二、松山秀一、石井健容、関誠、濱田俊哉

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    Application no:特願2013-151440