Updated on 2022/04/01

写真a

 
AZUMA Naoki
 
Organization
Graduate School of Engineering Micro-Nano Mechanical Science and Engineering 1 Assistant Professor
Graduate School
Graduate School of Engineering
Undergraduate School
School of Engineering Mechanical and Aerospace Engineering
Title
Assistant Professor
Contact information
メールアドレス

Degree 1

  1. 博士(工学) ( 2018.3   名古屋大学 ) 

Research Interests 6

  1. ナノ計測

  2. バイオ計測

  3. マイクロ流体チップ

  4. 超解像イメージング

  5. マイクロ・ナノレオロジー

  6. トライボロジー

Research Areas 3

  1. Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Measurement engineering  / マイクロ・ナノ計測

  2. Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering) / Fluid engineering  / ナノマイクロ流体,ナノレオロジー

  3. Nanotechnology/Materials / Nano/micro-systems  / ナノマイクロ流体デバイス

Current Research Project and SDGs 2

  1. ナノすきまに閉じ込められた液体の流れ・すきま分布計測

  2. マイクロ流体デバイスと光学的超解像法によるDNA一分子分析

Research History 2

  1. JST ACT-X 研究者

    2021.10

  2. Nagoya University   Assistant Professor

    2018.4

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    Country:Japan

Education 1

  1. Nagoya University   Graduate School, Division of Engineering

    2016.4 - 2018.3

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    Country: Japan

Professional Memberships 3

  1. 機械学会

  2. 応用物理学会

  3. トライボロジー学会

Committee Memberships 6

  1. 日本機械学会   情報・知能・精密機器部門 学術委員会 幹事  

    2022.4 - 2023.3   

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    Committee type:Academic society

  2. 日本機械学会   2022 JSME-IIP/ASME-ISPS Joint Conference on Micromechatronics for Information and Precision Equipment (MIPE2022, Nagoya, Japan) 委員  

    2021.4 - 2022.8   

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    Committee type:Academic society

  3. 日本トライボロジー学会   編集委員会 委員  

    2021.4 - 2022.3   

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    Committee type:Academic society

  4. 日本トライボロジー学会   編集委員会 委員 校閲幹事  

    2020.4 - 2021.3   

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    Committee type:Academic society

  5. 日本機械学会   情報・知能・精密機器部門)編集委員会 幹事  

    2020.4 - 2021.3   

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    Committee type:Academic society

  6. 日本トライボロジー学会   編集委員会 委員  

    2019.4 - 2020.3   

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Awards 2

  1. 日本機械学会若手優秀講演フェロー賞

    2016.3   日本機械学会  

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. 武藤栄次賞優秀学生賞

    2014.3   日本設計工学会  

 

Papers 32

  1. In-situ measurement of temporal changes in thickness of polymer adsorbed films from lubricant oil by vertical-objective-based ellipsometric microscopy Reviewed

    Yuxi Song, Kenji Fukuzawa, Shintaro Itoh, Hedong Zhang, Naoki Azuma

    Tribology International   Vol. 165   page: 107341 - 107341   2022.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.triboint.2021.107341

    Web of Science

    Scopus

  2. Fabrication of Microfluidic Device by Reactive Ion Etching and Focused Ion Beam Milling Invited

    Naoki Azuma

    JOURNAL OF JAPANESE SOCIETY OF TRIBOLOGISTS   Vol. 66 ( 10 ) page: 762 - 767   2021.10

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (other academic)   Publisher:Japanese Society of Tribologists  

    <p>Microfluidic devices are technologies that integrate micro- and nano-meter sized structures in a microchannel using a microfabrication technique. In this article, I focused on the fabrication process of our developed microfluidic device which is based on the principle of size exclusion chromatography for DNA separation. Since this device has microfence structures and nanoslit structures in a microchannel, its fabrication process consists of a photolithography and a reactive ion etching for creating the microfence structures and a focused ion beam milling for creating the nanoslit structures. Additionally, I introduced the experimental results of DNA separation using our fabricated microfluidic device. Beyond the research field of analytical chemistry, microfluidic devices have been utilized to other research fields such as rheology for the measurement of viscosity and flow distribution of liquids. I hope that this article will be of interest to the readership in the research field of tribology.</p>

    DOI: 10.18914/tribologist.66.10_762

    CiNii Research

  3. Prologue to the Special Issue on “Fabrication Technologies of Micro and Nano Structures and Their Applications” Invited

    Naoki Azuma

    JOURNAL OF JAPANESE SOCIETY OF TRIBOLOGISTS   Vol. 66 ( 10 ) page: 737 - 737   2021.10

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (other academic)   Publisher:Japanese Society of Tribologists  

    DOI: 10.18914/tribologist.66.10_737

    CiNii Research

  4. Super-localization of individual fluorophores along a DNA strand in a microchannel Reviewed

    Naoki Azuma, Kenji Fukuzawa, Shintaro Itoh

    Applied Physics Letters   Vol. 119 ( 2 ) page: 023701 - 023701   2021.7

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1063/5.0046939

  5. Simultaneous Measurement of Viscoelasticity and Film Thickness during Shearing of Patterned Hydrated Polymer Brush Film

    LIN Fengchang, ITOH Shintaro, FUKUZAWA Kenji, ZHANG Hedong, AZUMA Naoki

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2021 ( 0 ) page: IIP1B1-4   2021.3

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    Language:Japanese   Publishing type:Research paper (other academic)   Publisher:The Japan Society of Mechanical Engineers  

    <p>2-methacryloyloxyethyl phosphorylcholine (MPC) polymer is a promising coating material for extending the useful life of artificial joints due to its biocompatibility and lubricity. Especially, the hydrated brush-like MPC polymer film showed a low coefficient of friction. However, the mechanism of the lubricity is not fully understood. Friction coefficients of the MPC polymer films showed dependency on the shear gap, which must be caused by the thickness dependence of the film's mechanical properties (viscoelasticity). However, due to the thin film thickness (around 100 nm), it was difficult to measure the viscoelasticity. Thus, this research aimed to measure the hydrated MPC polymer brush film's viscoelasticity and elucidate its gap dependency. We established a measurement method that realizes simultaneous measurement of shear viscoelasticity and film thickness.</p>

    DOI: 10.1299/jsmeiip.2021.iip1b1-4

    CiNii Research

  6. Measurement of squeeze flow in micrometer-sized gap using single molecule tracking of quantum dot

    MIKI Katsuki, AZUMA Naoki, FUKUZAWA Kenji, ITOH Shintaro, ZHANG Hedong

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2021 ( 0 ) page: IIP1B1-3   2021.3

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    Language:Japanese   Publishing type:Research paper (other academic)   Publisher:The Japan Society of Mechanical Engineers  

    <p>The lubrication phenomena of lubricants confined in a nanometer-sized gap are different from those in the bulk state. Clarifying the mechanism of them requires the method to measure the lubricant flow in the nanometer-sized gap. Therefore, we proposed the method to measure the lubricant flow using single molecule tracking of quantum dots with the fluorescence microscope. A single quantum dot has the diameter of several tens of nm and can be applied to measure the lubricant flow in nanometer-sized gap. In this study, we tried to measure the squeeze flow of lubricants in micrometer-sized gap to verify the validity of our proposed method. Our obtained velocities of the squeeze flow were good agreement with those of theoretical model, that indicated the validity of our method.</p>

    DOI: 10.1299/jsmeiip.2021.iip1b1-3

    CiNii Research

  7. Reactive Molecular Dynamics Study of Effect of Water and Oxygen Molecules on Decomposition of PFPE Lubricant Films in Heat-Assisted Magnetic Recording

    AOTO Takumi, CHEN Xingyu, ZHANG Hedong, FUKUZAWA Kenji, ITOH Shintaro, AZUMA Naoki

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2021 ( 0 ) page: IIP2A3-3   2021.3

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    Language:Japanese   Publishing type:Research paper (other academic)   Publisher:The Japan Society of Mechanical Engineers  

    <p>To realize heat-assisted magnetic recording (HAMR), which can largely increase the recording density of hard disk drives, it is crucial to ensure the reliability and durability of the head disk interface (HDI) that involves high temperature and high-speed shear. In this study, we performed reactive molecular dynamics simulations to clarify the effects of water and oxygen molecules on the decomposition of nanometer-thick perfluoropolyether D-4OH films that lubricate the HDI of HAMR. From the simulation results, we found that water molecules accelerate the decomposition of D-4OH and this effect is suppressed by the presence of oxygen molecules. We also found that high normal pressures and concentrations of water and oxygen molecules lead to fast decomposition of D-4OH molecules.</p>

    DOI: 10.1299/jsmeiip.2021.iip2a3-3

    CiNii Research

  8. Measurement of Surface Adsorption Characteristics to Elucidate the Action Mechanism of Organic Friction Modifiers in Lubricating Oil

    KUZUYA Kohei, ZHANG Hedong, FUKUZAWA Kenji, ITOH Shintaro, AZUMA Naoki, HOR Seanghai, TSUKAMOTO Masaki

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2021 ( 0 ) page: IIP1B1-2   2021.3

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    Language:Japanese   Publishing type:Research paper (other academic)   Publisher:The Japan Society of Mechanical Engineers  

    <p>High performance environment-friendly organic friction modifier (OFM) additives are crucial for reducing energy loss and greenhouse gases due to friction and wear. In this study, we designed and synthesized a new type of TEMPO-based OFMs which contain a cyclic structure and free radical. In addition to friction and wear measurements, surface adsorption characteristics of the OFMs were measured with quartz crystal microbalance (QCM). We confirmed that Amide-TEMPO exhibits better friction and wear reduction effect than the conventional glyceryl monooleate. The friction coefficient correlated negatively with the adsorption equilibrium constant, but it showed no correlation with the adsorption density. The anti-wear performance showed no correlation with both adsorption equilibrium constant and adsorption density, suggesting that it is difficult to interpret the wear characteristics simply from the static adsorption characteristics measured by QCM.</p>

    DOI: 10.1299/jsmeiip.2021.iip1b1-2

    CiNii Research

  9. Measurement of escape time of concentrated DNA molecules in front of a nanogap Reviewed

    Naoki Azuma, Kenji Fukuzawa, Shintaro Itoh

    Applied Physics Express   Vol. 14 ( 1 ) page: 015001 - 015001   2020.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:IOP Publishing  

    DOI: 10.35848/1882-0786/abd199

    Scopus

    Other Link: https://iopscience.iop.org/article/10.35848/1882-0786/abd199/pdf

  10. Optimizing on-chip concentration of DNA molecules against a nanoslit barrier Reviewed

    Naoki Azuma, Shintaro Itoh, Kenji Fukuzawa

    Microfluidics and Nanofluidics   Vol. 24 ( 86 ) page: 13   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10404-020-02392-w

    Scopus

  11. ReaxFF Reactive Molecular Dynamics Simulations of Mechano-chemical Decomposition of Perfluoropolyether Lubricants in Heat-assisted Magnetic Recording Reviewed

    Xingyu Chen, Kento Kawai, Hedong Zhang, Kenji Fukuzawa, Nobuaki Koga, Shintaro Itoh, Naoki Azuma

    Journal of Physical Chemistry C   Vol. 124 ( 41 ) page: 22496–22505   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.jpcc.0c06486

  12. Extension of measurement range of lubrication gap shape using vertical-objective-type ellipsometric microscopy with two compensator angles Reviewed

    Katsuya Namba, Kenji Fukuzawa, Shintaro Itoh, Hedong Zhang, Naoki Azuma

    Tribology International   Vol. 142 ( 105980 ) page: 8   2020.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.triboint.2019.105980

    Web of Science

    Scopus

  13. Dependence of stretching rate of DNA molecules on gas/liquid interface velocity in combing method using microchannel

    AZUMA Naoki, ASAI Taihei, FUKUZAWA Kenji, ITOH Shintaro, ZHANG Hedong

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2020 ( 0 ) page: 2C06   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    In this study, we stretched and immobilized a 48.5 kbp-DNA molecule using a pressure flow and a gas-liquid interface movement in a microchannel. A chip device with a straight microchannel was fabricated by transfering Si mold created by a photolithography to PDMS. The depth and width of the microchannel were 2 μm and 100 μm, respectively. We controlled the velocities of the pressure flow and the gas-liquid interface by controlling applied pressures into the microchannel in order to investigate the dependence of stretched rate of the DNA molecule on the velocities. We measured the sizes of stretched and immobilized DNA molecules in the microchannel at each applied pressure by analysing the fluorescent images obtained using a fluorescence microscope. We indicated that the increase of the applied pressure improved the stretched rate of DNAs and achieved the stretched rate of 70 % under the condition of 1150 μm / s (600 mbar).

    DOI: 10.1299/jsmeiip.2020.2c06

    CiNii Research

  14. Verification of the effect of electric field strength and gradient on the elongation of DNA molecules using the confinement effect

    NAGATA Haruka, Itoh Shintaro, Azuma Naoki, Fukuzawa Kenji, Zhang Hedong

    The Proceedings of Mechanical Engineering Congress, Japan   Vol. 2020 ( 0 ) page: J13115   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    <p>For reading out genomic information from a single molecule of DNA, it is required to establish a DNA extension method that stretches a DNA molecule existing in a random coil state in a solution. To achieve highly stretched DNA molecules, we utilized and experimentally verified the effect of hydrodynamic drag force and electric field gradient in addition to the effect of nano-confinement; channels heights smaller than the persistence length of DNA molecules. In our experimental results, we revealed that the higher the migration velocity, the higher the elongation rate of DNA molecules. Moreover, by comparing the elongation rate of molecules measured in rectangular and taper-shaped nanoslits, we were able to achieve a higher degree of elongation in the latter type, which had the electric field gradient.</p>

    DOI: 10.1299/jsmemecj.2020.j13115

    CiNii Research

  15. Friction Properties of Hydrated Phospholipid Polymer Brush Films Prepared by Surface Initiated Graft Polymerization

    HIROOKA Chizuru, ITOH Shintaro, FUKUZAWA Kenji, Zhang Hedong, AZUMA Naoki

    The Proceedings of Mechanical Engineering Congress, Japan   Vol. 2020 ( 0 ) page: J13121   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    DOI: 10.1299/jsmemecj.2020.j13121

    CiNii Research

  16. Coarse-grained Molecular Dynamics Study of Effect of Surface Roughness on Adsorption Behavior of Fatty Acid Additives in Lubricating Oil

    TANG Jiahao, ZHANG Hedong, FUKUZAWA Kenji, ITOH Shintaroh, AZUMA Naoki

    The Proceedings of Mechanical Engineering Congress, Japan   Vol. 2020 ( 0 ) page: J13109   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    <p>Coarse-grained molecular dynamics simulations were performed to compare the adsorption of organic friction modifier (OFM) added in lubricating oil to flat and corrugated surfaces. Stearic acid, dodecane, and hematite were used as the OFM, lubricating oil, and solid surfaces, respectively. The simulation results showed that the increase in the surface number density of adsorbed stearic acid molecules in 100 ns simulations at 353 K was approximately four times faster on the corrugated surface than on the flat surface. We infer that surface roughness may promote adsorption of OFM additives, owing to the enhanced liquid–solid interactions at the corners formed between adjacent layers of solid surfaces.</p>

    DOI: 10.1299/jsmemecj.2020.j13109

    CiNii Research

  17. Reactive Molecular Dynamics Study of Thermal Decomposition and Transfer of Perfluoropolyether Lubricant in Heat-assisted Magnetic Recording

    CHEN Xingyu, ZHANG Hedong, FUKUZAWA Kenji, ITOH Shintaro, AZUMA Naoki

    The Proceedings of Mechanical Engineering Congress, Japan   Vol. 2020 ( 0 ) page: S16102   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    <p>To achieve reliable heat-assisted magnetic recording (HAMR), it is crucial to understand the decomposition of perfluoropolyether (PFPE) lubricant films. In this study, we performed reactive all-atom molecular dynamics simulations to investigate the thermal decomposition of PFPE D-4OH using our original ReaxFF force field. The results showed that the thermal decomposition of D-4OH molecules is mainly attributed to the dissociation of C–O bond in the polar end groups and the dissociated fragments transfer from the disk to head and form smears. On the other hand, by quantifying the decomposition time constants at 700 and 800 K, we infer that the thermal decomposition of D-4OH films hardly occurs within the HAMR heating time of ~1 ns.</p>

    DOI: 10.1299/jsmemecj.2020.s16102

    CiNii Research

  18. Reactive Molecular Dynamics Study of Mechano-chemical Decomposition of Perfluoropolyether Lubricants in Heat-assisted Magnetic Recording

    CHEN Xingyu, KAWAI Kento, ZHANG Hedong, FUKUZAWA Kenji, ITOH Shintaro, AZUMA Naoki

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2020 ( 0 ) page: 1A06   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    To achieve effective lubrication of head-disk interface in heat-assisted magnetic recording (HAMR),
    mechano-chemical decomposition of nonpolar and polar perfluoropolyether (PFPE) lubricant films, i.e., Z, Z-tetraol, Demnum, and D-4OH, was investigated using reactive molecular dynamics. By fitting with quantum calculation results, the reactive force field (ReaxFF) for PFPE was developed, allowing simulation of chemical reactions of PFPE lubricants. The results showed that at a temperature of 700 K, pure thermal decomposition of PFPE hardly occurs within the nanosecond heating time of HAMR, whereas mechano-chemical decomposition is highly possible to occur when normal pressure and shear are applied by the head and disk. We confirmed that thermal decomposition is mainly caused by the dissociation of C–O bond at the polar end groups and mechano-chemical decomposition is caused by dissociation of C–O bonds at both the polar end groups and main chains.

    DOI: 10.1299/jsmeiip.2020.1a06

    CiNii Research

  19. Viscosity measurement of lubricant at uniform small gaps by fluorescence correlation spectroscopy with micro-fluidic device

    HASEGAWA Sho, KIMOTO Takayuki, FUKUZAWA Kenji, ITOH Shintaro, ZHANG Hedong

    The Proceedings of Mechanical Engineering Congress, Japan   Vol. 2020 ( 0 ) page: J13112   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    DOI: 10.1299/jsmemecj.2020.j13112

    CiNii Research

  20. Viscosity measurement of lubricant at uniform small gaps by combining microfluidic device and fluorescence correlation spectroscopy

    KIMOTO Takayuki, FUKUZAWA Kenji, ITOH Shintrao, AZUMA Naoki, ZHANG Hedong

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2020 ( 0 ) page: 2C08   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    Measurement of the viscosity of the lubricant in the minute gap is important for elucidating the boundary and mixed lubrication characteristics. It has become clear that the lubricant has a specific viscosity depending on the small gap. Since the viscosity depends on the gap, measurement at a constant (uniform) gap in the measurement region was essential, but it was difficult with a gap of the order of 10 nm. In this study, we propose a method for measuring the viscosity of lubricant in a uniform small gap by combining microfluidic device and fluorescence correlation spectroscopy.

    DOI: 10.1299/jsmeiip.2020.2c08

    CiNii Research

  21. Shear gap determination method by optical interference fringes measurement for quantifying shear viscoelasticity of nanometer-thick phospholipid polymer brush films

    LIN Fengchang, ITOH Shintaro, FUKUZAWA Kenji, ZHANG Hedong, AZUMA Naoki

    The Proceedings of Mechanical Engineering Congress, Japan   Vol. 2020 ( 0 ) page: J13111   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    <p>2-Methacryloyloxyethyl phosphorylcholine (MPC) polymer is used as coating material on artificial joint for its hydrated lubricity. In order to elucidate the mechanism of the hydrated lubrication, in this research, we measure the shear viscoelasticity of hydrated MPC polymer films by using a fiber wobbling method (FWM). Simultaneously, we measure the shearing gap by combining microscope underneath the FWM setup and observing the interference fringe. We found that both viscosity and elasticity increased along with the decreasing of gap width. However, the MPC polymer showed a transition from viscous dominant to elastic dominant when the gap is smaller than a certain gap width. This implies that MPC films reduce friction as a low viscos fluid in large shearing gaps and prevent contact between surfaces in small gaps for reducing friction and wear. This may explain the mechanism of hydrated lubrication of MPC film coated on a surface of artificial joint.</p>

    DOI: 10.1299/jsmemecj.2020.j13111

    CiNii Research

  22. Molecular Elongation of Large Molecular Weight DNA Electrophoresed in Nanoslit Channel and Its Voltage Dependence

    NAGATA Haruka, ITOH Shintaro, AZUMA Naoki, FUKUZAWA Kenji, ZHANG Hedong

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2020 ( 0 ) page: 2C05   2020

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    Nanopore sequencer is expected as a core technology for realizing medical treatment based on genome information. In order to improve the analysis efficiency, it is necessary to be able to analyze a large molecular size genomic DNA (large molecular weight DNA) with one molecule. Large molecular weight DNA has a random coil structure in a stable state. Therefore, it is indispensable to establish the technology to extend the random coil-shaped DNA molecule linearly in order to realize the analysis with the nanopore sequencer. In this study, we experimentally verified the effect of migration conditions on the elongation rate of DNA molecules that elongate during electrophoresis in a nanoslit. The results showed that DNA elongation was significantly affected not only by the geometric conditions of the flow channel, but also by the electric field distribution (position within the nanoslit) and the migration speed.

    DOI: 10.1299/jsmeiip.2020.2c05

    CiNii Research

  23. Dynamic Viscoelasticity of Hydrated Phospholipid Polymer Brush Measured by Fiber Wobbling Method Invited Reviewed

    S. Itoh, S. Aoyama, Y. Higashizaka, K. Fukuzawa, H. Zhang, N. Azuma

    Proceedings of the STLE/ASME International Joint Tribology Conference     2019.10

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    Language:English   Publishing type:Research paper (international conference proceedings)  

  24. Gap and Shear Rate Dependence of Viscoelasticity of Lubricants with Polymer Additives Sheared in Nano Gaps Invited Reviewed

    S Itoh, R Aoki, K Fukuzawa, H Zhang, N Azuma, Y Onumata

    Proceedings of the STLE/ASME International Joint Tribology Conference     2019.10

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    Language:English   Publishing type:Research paper (international conference proceedings)  

  25. Measurement of Trapping Time of DNA Molecule in front of Nanogap Using Concentration Method

    AZUMA Naoki, FUKUZAWA Kenji, ITOH Shintaro, ZHANG Hedong

    The Proceedings of the Symposium on Micro-Nano Science and Technology   Vol. 2019.10 ( 0 ) page: 21pm1PN319   2019

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    <p>When a DNA molecule passes through a nanochannel which depth is smaller than its size, the molecule is trapped in front of the nanochannel based on an entropy trap. Trapping time τ is a parameter to characterize the entropy trap and measuring trapping time τ accurately is required to design DNA separation and concentration methods based on the entropy trap. In this study, we proposed an experimental measurement method of trapping time τ using DNA concentration method. We fabricated a chip device with a nanogap of 25-nm depth in a microchannel using microfabrication technique and succeeded in determining the voltage V dependence of trapping time τ of 48.5-kbp DNA by experiments with 0.8 - 1.2 V.</p>

    DOI: 10.1299/jsmemnm.2019.10.21pm1pn319

    CiNii Research

  26. Determination of optimal voltage by theoretical model for DNA concentration using nanoslit

    AZUMA Naoki, FUKUZAWA Kenji, ITOH Shintaro, ZHANG Hedong

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2019 ( 0 ) page: 2C01   2019

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    On-chip concentration is a method of concentrating biomolecules using a nanometer-sized structure created into a microchannel, which is effective for improving detection sensitivity for microfluidic devices. As an on -chip concentration method for DNA molecules, we proposed a concentration method using nanoslit, which was a gap smaller than a diameter of a single molecule. Since this concentration method was based on the principle of entropy trap, its concentration amount depended on applied voltage. In this study, we proposed a theoretical model of concentration using nanoslit and determined an optimal voltage at which maximizing the concentration amount. We fabricated a chip device with 25 nm-depth nanoslit using microfabrication technique and experimentally verified the validity of our model. We achieved the concentration of λ DNA molecules at 17 times when we applied 0.6 V for 15 s.

    DOI: 10.1299/jsmeiip.2019.2c01

    CiNii Research

  27. Separation of large DNA molecules by applying pulsed electric field to size exclusion chromatography-based microchip Reviewed

    Naoki Azuma, Shintaro Itoh, Kenji Fukuzawa, Hedong Zhang

    Japanese Journal of Applied Physics   Vol. 57 ( 2 ) page: 8   2018.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.7567/JJAP.57.027002

    Web of Science

    Scopus

  28. Optimization of applied voltages for on-chip concentration of DNA using nanoslit Reviewed

    Naoki Azuma, Shintaro Itoh, Kenji Fukuzawa, Hedong Zhang

    Japanese Journal of Applied Physics   Vol. 56 ( 12 ) page: 8   2017.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.7567/JJAP.56.127001

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    Scopus

  29. Fast size separation of large DNA molecules by applying pulsed electric field to size exclusion chromatography-based electrophoresis microchip

    AZUMA Naoki, ITOH Shintaro, FUKUZAWA Kenji, ZHANG Hedong

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2017 ( 0 ) page: E-01 - 1   2017

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    Size separation of large DNA molecules (10 kbp – 1000 kbp) is one of the fundamental procedures for identifying bacterium’s genotypes, which should be fast for quick defection of infectious diseases. In our conventional study, we developed an electrophoresis microchip based on size exclusion chromatography. This separation has an advantage that it does not cause large deformation of DNA, which is important for separation of large DNAs because they can be easily fragmented. We achieved separation of large DNAs (48 kbp + 166 kbp) driven by a direct electric field as electrophoretic condition of DNA. However, it caused long separation time (3000 s) because DNAs migration was slow due to low applied voltage for the separation. In this study, we achieved faster separation of DNAs using a pulsed electric field under which applied voltage can be higher.

    DOI: 10.1299/jsmeiip.2017.e-01

    CiNii Research

  30. On-chip concentration of DNA samples using a nano-slit fabricated in a microchannel

    Azuma Naoki, Itoh Shintaro, Fukuzawa Kenji, Zhang Hedong

    The Proceedings of the Symposium on Micro-Nano Science and Technology   Vol. 2017.8 ( 0 ) page: PN-106   2017

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    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    On-chip concentration of samples using nanometer-sized structures fabricated in a microchannel is an effective method to improve detection sensitivity in μTAS. We proposed on-chip concentration of DNA samples using a nano-slit, which is a channel with a depth smaller than a diameter of DNA molecule. The concentration is based on an entropy trap at the boundary between the microchannel and the nano-slit. Therefore, concentration is achieved only by adjusting applied voltages. In this study, we verified the feasibility and the performances of the proposed concentration experimentally. When we applied 0.3 V for 100 s by using 30-nm deep nano-slit, we succeeded in concentration of λ DNA at 25 times the concentration rate.

    DOI: 10.1299/jsmemnm.2017.8.pn-106

    CiNii Research

  31. Separation of large DNA molecules by size exclusion chromatography-based microchip with on-chip concentration structure Reviewed

    Naoki Azuma, Shintaro Itoh, Kenji Fukuzawa, Hedong Zhang

    Japanese Journal of Applied Physics   Vol. 55 ( 06GN01 ) page: 8   2016.4

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

  32. Improvement of resolution in SEC-type DNA separation microchip by on-chip concentration using nano-slit Reviewed

    Naoki Azuma, Shintaro Itoh, Yusuke Sugimoto, Kenji Fukuzawa, Hedong Zhang

    Proceedings of the JSME-IIP/ASME-ISPS Joint International Conference on Micromechatronics for Information and Precision Equipment   Vol. 2015 ( MoB-2-4 )   2015.6

     More details

    Authorship:Lead author   Language:English   Publishing type:Research paper (international conference proceedings)  

    DOI: https://doi.org/10.1299/jsmemipe.2015._MoB-2-4-1

▼display all

MISC 57

  1. ナノすき間でせん断される潤滑油のずり粘弾性と誘電緩和の同時計測

    勝野 翔太郎,伊藤 伸太郎,福澤 健二,東 直輝,張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会     2022.3

  2. 量子ドットの蛍光画像追跡を用いたナノすきまのスクイーズ流れ分布計測

    東 直輝,美木 克貴,福澤 健二,伊藤 伸太郎,張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会     2022.3

  3. 蛍光一分子像追跡によるナノすきまのスクイーズ流れ分布の定量計測

    美木 克貴, 東 直輝, 福澤 健二, 伊藤 伸太郎, 張 賀東

    応用物理学会春季学術講演会     2022.3

  4. 水と酸素の存在下における PFPE 潤滑膜のメカノケミカル反応の分子動力学解析

    稲吉 宏哉, 青砥 巧真, 陳 星宇, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会     2022.3

  5. ファイバーウォブリング法を応用したナノ厚さ光硬化性液体膜の硬化過程のリアルタイム計測

    荒谷 航平, 伊藤 伸太郎, 福澤 健二, 東 直輝, 張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会     2022.3

  6. ナノすき間を濡れ広がる光硬化性液体膜の観測

    伊藤 伸太郎,細井 勇佑,中西 優介,福澤 健二,東 直輝,張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会     2022.3

  7. 固液間の分子間相互作用を用いたナノメートル分解能を有する液体膜の厚さ制御法

    齋藤 佑樹,福澤 健二,伊藤 伸太郎,東 直輝,張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会     2022.3

  8. 有機摩擦調整剤の表面吸着特性と摩擦摩 耗特性の相関に関する研究

    LOW HONG LIAN, Seanghai Hor, 塚本眞幸, 張賀東, 福澤健二, 伊藤伸太郎, 東直輝

    トライボロジー会議2021 秋     2021.10

  9. ナノすき間でせん断される高分子添加潤滑 油粘度のずり速度依存性

    伊藤伸太郎, 青木亮介, 福澤健二, 東直輝, 張賀東

    トライボロジー会議2021 秋     2021.10

  10. ポリアルキルメタクリレート(PAMA)ポリマー 添加剤の極性が吸着・摩擦特性に及ぼす影響

    ソンユシ,葛冬萌, 福澤健二, 伊藤伸太郎, 張賀東, 東直輝

    トライボロジー会議2021 秋     2021.10

  11. 各種金属表面に対するフラーレン添加潤滑 油の摩擦・摩耗特性

    エン子昂, 伊藤伸太郎, 福澤健二, 東直輝, 張賀東

    トライボロジー会議2021 秋     2021.10

  12. ナノすきま潤滑現象解明のためのしゅう動部と駆動部を集積化したマイクロ流体デバイスの開発

    押谷 優太, 福澤 健二, 東 直輝, 伊藤 伸太郎, 張 賀東

    日本機械学会2021年度年次大会 論文集     2021.9

  13. ナノ厚さ液体膜を介した固体摺動面間の摩擦特性の数値解析

    李 雨潤, William Woei, Fong Chong, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝

    日本機械学会2021年度年次大会 論文集     2021.9

  14. 環状構造とラジカルを含む有機摩擦調整剤の性能に対する官能基の影響

    侯 金赤, Seanghai Hor, 塚本 眞幸, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝

    日本機械学会2021年度年次大会 論文集     2021.9

  15. 蛍光一分子追跡を用いた固体二面間のすきま狭小時のスクイーズ流れ計測

    美木 克貴, 東 直輝, 福澤 健二, 伊藤 伸太郎, 張 賀東

    日本機械学会2021年度年次大会 論文集     2021.9

  16. 表面開始グラフト重合により作成したナノ厚さ水和ポリマーブラシ膜の境界潤滑特性(膜厚と面圧に対する依存性)

    伊藤 伸太郎, 廣岡 千鶴, 望月 恭介, 福澤 健二, 張 賀東, 東 直輝

    日本機械学会2021年度年次大会 論文集     2021.9

  17. Stretching and fixing DNA molecules on air-plasma-treated surface by using an air/water interface in a microchannel

    Naoki AZUMA Shintaro ITOh, Kenji FUKUZAWA, Hedong ZHANG

    The 64th International Conference On Electron, Ion and Photon Beam Technology and Nanofabrication     2021.6

  18. 潤滑油からのポリアルキルメタクリレート (PAMA)ポリマー吸着膜の形成メカニズム と構造

    ソンユシ,福澤健二,伊藤伸太郎,張賀東,東直輝

    トライボロジー会議2021 春     2021.5

  19. ナノ深さ流路中での蛍光相関分析法によ る一様ナノすきまの潤滑剤の粘度計測

    高島純平,長谷川奨,福澤健二,東直輝,伊藤伸太郎,張賀東

    トライボロジー会議2021 春     2021.5

  20. ナノすき間でせん断される潤滑油粘弾性 に対するポリアルキルメタクリレート系添 加剤の分子量の影響

    大久保尚哉, 伊藤伸太郎,福澤健二,張賀東,東直輝

    トライボロジー会議2021 春     2021.5

  21. 水和したリン脂質ポリマーブラシの動的ず り粘弾性のせん断隙間依存性(第3報)

    林楓昌,伊藤伸太郎,福澤健二,張賀東,東直輝

    トライボロジー会議2021 春     2021.5

  22. 垂直観測型エリプソメトリー顕微鏡を用い たナノすきま液体のすきま一定型せん断 応答計測

    加藤剛史,山中魁人 ,福澤健二,伊藤伸太郎,東直輝,張賀東

    トライボロジー会議2021 春     2021.5

  23. マイクロ流路内の気液界面移動によるDNA 分子の伸長・固定と一分子の超解像イメージング

    東 直輝, 福澤 健二, 伊藤 伸太郎

    2021年第68回応用物理学会春季学術講演会     2021.3

  24. 熱アシスト磁気記録における PFPE 潤滑膜の分解に及ぼす水と酸素分子の影響に関する反応分子動力学解析

    青砥 巧真, 陳 星宇, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝

    IIP2021 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2021.3

  25. 潤滑油中における有機摩擦調整剤の作用メカニズム解明のための表面吸着特性計測

    葛谷 光平, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝, Seanghai Hor, 塚本 眞幸

    IIP2021 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2021.3

  26. 量子ドットを用いた蛍光一分子追跡によるマイクロすきまのスクイーズ流れ計測

    美木 克貴, 東 直輝, 福澤 健二, 伊藤 伸太郎, 張 賀東

    IIP2021 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2021.3

  27. パターニングした水和ポリマーブラシ膜のせん断時における粘弾性と膜厚の同時計測

    林 楓昌, 伊藤 伸太郎, 福澤 健二, 張 賀東, 東 直輝

    IIP2021 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2021.3

  28. ファイバーウォブリング法によるフラーレン添加潤滑油の界面粘弾性計測

    伊藤伸太郎,永井達也,福澤健二,東直輝,張賀東

    トライボロジー会議2020 秋 別府     2020.11

  29. 垂直観測型エリプソメトリー顕微鏡を用いたナノすきま液体のせん断応答計測

    山中魁人,福澤健二,東直輝,伊藤伸太郎,張賀東

    トライボロジー会議2020 秋 別府     2020.11

  30. 粗視化分子動力学法を用いた表面粗さが潤滑油中の脂肪酸添加剤の吸着挙動に及ぼす影響の解析

    湯 嘉コウ,張 賀東,福澤 健二,伊藤 伸太郎,東 直輝

    日本機械学会2020年度年次大会論文集     2020.9

  31. 反応分子動力学による熱アシスト磁気記録における PFPE 潤滑膜の熱分解と移着の解析

    陳 星宇,張 賀東,福澤 健二,伊藤 伸太郎,東 直輝

    日本機械学会2020年度年次大会     2020.9

  32. 表面開始グラフト重合により作成したリン脂質ポリマーブラシ膜の水和状態における摩擦特性(水中に浮遊したポリマーの影響)

    廣岡 千鶴,伊藤 伸太郎,福澤 健二,張 賀東,東 直輝

    日本機械学会2020年度年次大会論文集     2020.9

  33. マイクロ流体デバイスを用いた蛍光相関分光法による一様微小隙間での潤滑剤粘度計測

    長谷川 奨,木本 貴幸,福澤 健二,伊藤 伸太郎,東 直輝,張 賀東

    日本機械学会2020年度年次大会論文集     2020.9

  34. ナノ厚さリン脂質ポリマーブラシ膜のずり粘弾性定量化に向けた光干渉縞計測によるせん断すき間同定法

    林 楓昌,伊藤 伸太郎,福澤 健二,張 賀東,東 直輝

    日本機械学会2020年度年次大会論文集     2020.9

  35. 反応分子動力学による熱アシスト磁気記録におけるPFPE潤滑膜のメカノケミカル分解解析

    陳星宇,川合健斗,張賀東,福澤健二,伊藤伸太郎,東直輝

    IIP2020 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2020.3

  36. DNA1分子サイズ測定のための微小流路内の気液界面の移動を用いた分子の伸長・固定~分子伸長率の気液界面の移動速度依存性~

    東 直輝,浅井 泰平,福澤 健二,伊藤 伸太郎,張 賀東

    IIP2020 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2020.3

  37. 隙間制御機構を付与した原子間力顕微鏡プローブによる微小隙間のスクイズ力計測

    稲川 賢人,福澤 健二,伊藤 伸太郎,張 賀東

    IIP2020 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2020.3

  38. マイクロ流体デバイスと蛍光相関分光法の組み合わせによる一様微小隙間での潤滑剤粘度計測

    木本 貴幸,福澤 健二,伊藤 伸太郎,東 直輝,張 賀東

    IIP2020 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2020.3

  39. ナノスリット流路を電気泳動する大分子量DNAの分子伸長とその電圧依存性

    永田春香,伊藤伸太郎,東 直輝,福澤 健二,張 賀東

    IIP2020 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2020.3

  40. DNA分子濃縮を用いたナノ隙間手前の分子のトラップ時間の測定

    東直輝, 福澤健二, 伊藤伸太郎, 張賀東

    第10回マイクロ・ナノ工学シンポジウム     2019.11

  41. Dynamic Viscoelasticity of Hydrated Phospholipid Polymer Brush Measured by Fiber Wobbling Method

    Shintaro Itoh, Shoko Aoyama, Yuu Higashizaka, Kenji Fukuzawa, Hedong Zhang, Naoki Azuma

    2019 STLE Tribology Frontiers Conference     2019.10

  42. Measurement of Trapping Time of DNA Molecule in Nanofluidic Entropy Trap using DNA Concentration

    Naoki Azuma Shintaro Itoh, Kenji Fukuzawa, Hedong Zhang

    32nd International Microprocesses and Nanotechnology Conference     2019.10

  43. Stretching of DNA Molecules Migrating through a Nanoslit by Electrophoresis and Its Dependence on Voltages

    Haruka Nagata, Shintaro Itoh, Naoki Azuma, Kenji Fukuzawa, Hedong Zhang

    32nd International Microprocesses and Nanotechnology Conference     2019.10

  44. Gap and Shear Rate Dependence of Viscoelasticity of Lubricants with Polymer Additives Sheared in Nano Gap

    Shintaro Itoh, Kenji Fukuzawa, Ryosuke Aoki, Hedong Zhang, Naoki Azuma, Yasushi Onuma

    2019 STLE Tribology Frontiers Conference     2019.10

  45. 水和したリン脂質ポリマーブラシの動的ずり粘弾性のせん断隙間依存性(第2報)

    伊藤伸太郎,青山祥子,東坂悠,福澤健二,張賀東,東直輝

    トライボロジー会議2019春 東京     2019.5

  46. ナノスリットによるDNA分子濃縮における理論モデルを用いた印加電圧の最適化

    東 直輝,福澤 健二,伊藤 伸太郎,張 賀東

    IIP2019情報・知能・精密機器部門(IIP部門)講演会     2019.3

  47. ポリイソブチレンを添加したポリアルファオレフィン潤滑油のナノ隙間におけるずり粘弾性

    青木亮介,伊藤伸太郎,福澤健二,張賀東,東直輝

    トライボロジー会議2018 秋 伊勢     2018.11

  48. しゅう動痕に形成されたサブミクロン厚さグリース膜のファイバーウォブリング法による粘弾性計測

    穴井達啓,伊藤伸太郎,福澤健二,張賀東,東直輝,根岸秀世

    トライボロジー会議2018 秋 伊勢     2018.11

  49. 水和したリン脂質ポリマーブラシの動的粘弾性のせん断隙間依存性

    青山祥子,伊藤伸太郎,福澤健二,張賀東,東直輝

    トライボロジー会議2018 秋 伊勢     2018.11

  50. マイクロ流路内に形成したナノスリットによるDNA試料のオンチップ濃縮

    東 直輝, 伊藤 伸太郎, 福澤 健二, 張 賀東

    第8回マイクロ・ナノ工学シンポジウム2017     2017.10

  51. Fast size separation of large DNA molecules by applying pulsed electric field to size exclusion chromatography-based electrophoresis microchip

    AZUMA Naoki, ITOH Shintaro, FUKUZAWA Kenji, ZHANG Hedong

    The Proceedings of the Conference on Information, Intelligence and Precision Equipment : IIP   Vol. 2017 ( 0 ) page: E - 1   2017

     More details

    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    Size separation of large DNA molecules (10 kbp – 1000 kbp) is one of the fundamental procedures for identifying bacterium&amp;rsquo;s genotypes, which should be fast for quick defection of infectious diseases. In our conventional study, we developed an electrophoresis microchip based on size exclusion chromatography. This separation has an advantage that it does not cause large deformation of DNA, which is important for separation of large DNAs because they can be easily fragmented. We achieved separation of large DNAs (48 kbp + 166 kbp) driven by a direct electric field as electrophoretic condition of DNA. However, it caused long separation time (3000 s) because DNAs migration was slow due to low applied voltage for the separation. In this study, we achieved faster separation of DNAs using a pulsed electric field under which applied voltage can be higher.

  52. On-chip concentration of DNA samples using a nano-slit fabricated in a microchannel

    Azuma Naoki, Itoh Shintaro, Fukuzawa Kenji, Zhang Hedong

    The Proceedings of the Symposium on Micro-Nano Science and Technology   Vol. 2017 ( 0 ) page: PN - 106   2017

     More details

    Language:Japanese   Publisher:The Japan Society of Mechanical Engineers  

    On-chip concentration of samples using nanometer-sized structures fabricated in a microchannel is an effective method to improve detection sensitivity in μTAS. We proposed on-chip concentration of DNA samples using a nano-slit, which is a channel with a depth smaller than a diameter of DNA molecule. The concentration is based on an entropy trap at the boundary between the microchannel and the nano-slit. Therefore, concentration is achieved only by adjusting applied voltages. In this study, we verified the feasibility and the performances of the proposed concentration experimentally. When we applied 0.3 V for 100 s by using 30-nm deep nano-slit, we succeeded in concentration of λ DNA at 25 times the concentration rate.

  53. Reduction of Analysis Time in the Size Separation of Large DNA Using Size Exclusion Chromatography-Based Electrophoresis Microchip Driven by Pulsed Electric Field.

    Naoki Azuma,Shintaro Itoh,,Kenji Fukuzawa,Hedong Zhang

    29th International Microprocesses and Nanotechnology Conference (MNC2016)     2016.11

  54. 電気泳動マイクロチップによる大分子量DNAサイズ分離(理論モデル解析に基づく泳動電圧の最適化)

    東 直輝, 伊藤 伸太郎,  福澤 健二, 張 賀東

    IIP2016 情報・知能・精密機器部門(IIP部門)講演会 講演論文集     2016.3

  55. Separation of Large DNA Molecules by Size Exclusion Chromatography Type Microchip with on-Chip Concentration Structure

    Naoki Azuma,Shintaro Itoh,,Kenji Fukuzawa,Hedong Zhang

    28th International Microprocesses and Nanotechnology Conference(MNC2015)     2015.11

  56. Improvement of resolution in sec-type dna separation microchip by on-chip concentration using nano-slit

    Naoki Azuma, Shintaro Itoh, Yusuke Sugimoto, Kenji Fukuzawa, Hedong Zhang

    2015 JSME-IIP/ASME-ISPS Joint International Conference on Micromechatronics for Information and Precision Equipment (MIPE2015)     2015.6

  57. ナノスリットを用いたオンチップ濃縮によるサイズ排除型DNA分離法の分離能の向上

    東 直輝, 伊藤 伸太郎, 杉本 悠介, 福澤 健二, 張 賀東

    日本機械学会2014年度年次大会論文集     2014.9

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Presentations 55

  1. 蛍光一分子像追跡によるナノすきまのスクイーズ流れ分布の定量計測

    美木 克貴, 東 直輝, 福澤 健二, 伊藤 伸太郎, 張 賀東

    応用物理学会春季学術講演会 

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    Event date: 2022.3

  2. 量子ドットの蛍光画像追跡を用いたナノすきまのスクイーズ流れ分布計測

    東 直輝,美木 克貴,福澤 健二,伊藤 伸太郎,張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2022.3

  3. ナノすき間でせん断される潤滑油のずり粘弾性と誘電緩和の同時計測

    勝野 翔太郎,伊藤 伸太郎,福澤 健二,東 直輝,張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2022.3

  4. ナノすき間を濡れ広がる光硬化性液体膜の観測

    伊藤 伸太郎, 細井 勇佑, 中西 優介, 福澤 健二, 東 直輝, 張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2022.3

  5. 水と酸素の存在下における PFPE 潤滑膜のメカノケミカル反応の分子動力学解析

    稲吉 宏哉, 青砥 巧真, 陳 星宇, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2022.3

  6. 固液間の分子間相互作用を用いたナノメートル分解能を有する液体膜の厚さ制御法

    齋藤 佑樹, 福澤 健二, 伊藤 伸太郎, 東 直輝, 張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2022.3

  7. ファイバーウォブリング法を応用したナノ厚さ光硬化性液体膜の硬化過程のリアルタイム計測

    荒谷 航平, 伊藤 伸太郎, 福澤 健二, 東 直輝, 張 賀東

    IIP2022 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2022.3

  8. 有機摩擦調整剤の表面吸着特性と摩擦摩 耗特性の相関に関する研究

    LOW HONG LIAN, Seanghai Hor, 塚本眞幸, 張賀東, 福澤健二, 伊藤伸太郎, 東直輝

    トライボロジー会議2021 秋 

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    Event date: 2021.10

    Presentation type:Oral presentation (general)  

  9. ナノすき間でせん断される高分子添加潤滑 油粘度のずり速度依存性

    伊藤伸太郎, 青木亮介, 福澤健二, 東直輝, 張賀東

    トライボロジー会議2021 秋 

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    Event date: 2021.10

    Presentation type:Oral presentation (general)  

  10. ポリアルキルメタクリレート(PAMA)ポリマー 添加剤の極性が吸着・摩擦特性に及ぼす影 響

    ソンユシ,葛冬萌, 福澤健二, 伊藤伸太郎, 張賀東, 東直輝

    トライボロジー会議2021 秋 

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    Event date: 2021.10

    Presentation type:Oral presentation (general)  

  11. 各種金属表面に対するフラーレン添加潤滑 油の摩擦・摩耗特性

    エン子昂, 伊藤伸太郎, 福澤健二, 東直輝, 張賀東

    トライボロジー会議2021 秋 

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    Event date: 2021.10

    Presentation type:Oral presentation (general)  

  12. 表面開始グラフト重合により作成したナノ厚さ水和ポリマーブラシ膜の境界潤滑特性(膜厚と面圧に対する依存性)

    伊藤 伸太郎, 廣岡 千鶴, 望月 恭介, 福澤 健二, 張 賀東, 東 直輝

    日本機械学会2021年度年次大会 

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    Event date: 2021.9

    Presentation type:Oral presentation (general)  

  13. ナノすきま潤滑現象解明のためのしゅう動部と駆動部を集積化したマイクロ流体デバイスの開発

    押谷 優太, 福澤 健二, 東 直輝, 伊藤 伸太郎, 張 賀東

    日本機械学会2021年度年次大会 

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    Event date: 2021.9

    Presentation type:Oral presentation (general)  

  14. ナノ厚さ液体膜を介した固体摺動面間の摩擦特性の数値解析

    李 雨潤, William Woei, Fong Chong, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝

    日本機械学会2021年度年次大会 

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    Event date: 2021.9

    Presentation type:Oral presentation (general)  

  15. 環状構造とラジカルを含む有機摩擦調整剤の性能に対する官能基の影響

    侯 金赤, Seanghai Hor, 塚本 眞幸, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝

    日本機械学会2021年度年次大会 

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    Event date: 2021.9

    Presentation type:Oral presentation (general)  

  16. 蛍光一分子追跡を用いた固体二面間のすきま狭小時のスクイーズ流れ計測

    美木 克貴, 東 直輝, 福澤 健二, 伊藤 伸太郎, 張 賀東

    日本機械学会2021年度年次大会 

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    Event date: 2021.9

    Presentation type:Oral presentation (general)  

  17. Stretching and fixing DNA molecules on air-plasma-treated surface by using an air/water interface in a microchannel

    Naoki AZUMA Shintaro ITOh, Kenji FUKUZAWA, Hedong ZHANG

    The 64th International Conference On Electron, Ion and Photon Beam Technology and Nanofabrication 

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    Event date: 2021.6

  18. 潤滑油からのポリアルキルメタクリレート (PAMA)ポリマー吸着膜の形成メカニズム と構造

    ソンユシ,福澤健二,伊藤伸太郎,張賀東,東直輝

    トライボロジー会議2021 春 

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    Event date: 2021.5

  19. 水和したリン脂質ポリマーブラシの動的ず り粘弾性のせん断隙間依存性(第3報)

    林楓昌,伊藤伸太郎,福澤健二,張賀東,東直輝

    トライボロジー会議2021 春 

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    Event date: 2021.5

  20. 垂直観測型エリプソメトリー顕微鏡を用い たナノすきま液体のすきま一定型せん断 応答計測

    加藤剛史,山中魁人 ,福澤健二,伊藤伸太郎,東直輝,張賀東

    トライボロジー会議2021 春 

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    Event date: 2021.5

  21. ナノすき間でせん断される潤滑油粘弾性 に対するポリアルキルメタクリレート系添 加剤の分子量の影響

    大久保尚哉, 伊藤伸太郎,福澤健二,張賀東,東直輝

    トライボロジー会議2021 春 

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    Event date: 2021.5

  22. ナノ深さ流路中での蛍光相関分析法によ る一様ナノすきまの潤滑剤の粘度計測

    高島純平,長谷川奨,福澤健二,東直輝,伊藤伸太郎,張賀東

    トライボロジー会議2021 春 

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    Event date: 2021.5

  23. マイクロ流路内の気液界面移動によるDNA 分子の伸長・固定と一分子の超解像イメージング

    東 直輝, 福澤 健二, 伊藤 伸太郎

    2021年第68回応用物理学会春季学術講演会 

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    Event date: 2021.3

  24. パターニングした水和ポリマーブラシ膜のせん断時における粘弾性と膜厚の同時計測

    林 楓昌, 伊藤 伸太郎, 福澤 健二, 張 賀東, 東 直輝

    IIP2021 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2021.3

  25. 熱アシスト磁気記録における PFPE 潤滑膜の分解に及ぼす水と酸素分子の影響に関する反応分子動力学解析

    青砥 巧真, 陳 星宇, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝

    IIP2021 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2021.3

  26. 潤滑油中における有機摩擦調整剤の作用メカニズム解明のための表面吸着特性計測

    葛谷 光平, 張 賀東, 福澤 健二, 伊藤 伸太郎, 東 直輝, Seanghai Hor, 塚本 眞幸

    IIP2021 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2021.3

  27. 量子ドットを用いた蛍光一分子追跡によるマイクロすきまのスクイーズ流れ計測

    美木 克貴, 東 直輝, 福澤 健二, 伊藤 伸太郎, 張 賀東

    IIP2021 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2021.3

  28. ファイバーウォブリング法によるフラーレン添加潤滑油の界面粘弾性計測

    伊藤伸太郎,永井達也,福澤健二,東直輝,張賀東

    トライボロジー会議2020 秋  

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    Event date: 2020.11

  29. 垂直観測型エリプソメトリー顕微鏡を用いたナノすきま液体のせん断応答計測

    山中魁人,福澤健二,東直輝,伊藤伸太郎,張賀東

    トライボロジー会議2020 秋  

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    Event date: 2020.11

  30. 粗視化分子動力学法を用いた表面粗さが潤滑油中の脂肪酸添加剤の吸着挙動に及ぼす影響の解析

    湯 嘉コウ,張 賀東,福澤 健二,伊藤 伸太郎,東 直輝

    日本機械学会2020年度年次大会  

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    Event date: 2020.9

    Language:Japanese   Presentation type:Oral presentation (general)  

  31. 反応分子動力学による熱アシスト磁気記録における PFPE 潤滑膜の熱分解と移着の解析

    陳 星宇,張 賀東,福澤 健二,伊藤 伸太郎,東 直輝

    日本機械学会2020年度年次大会  

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    Event date: 2020.9

  32. 表面開始グラフト重合により作成したリン脂質ポリマーブラシ膜の水和状態における摩擦特性(水中に浮遊したポリマーの影響)

    廣岡 千鶴,伊藤 伸太郎,福澤 健二,張 賀東,東 直輝

    日本機械学会2020年度年次大会  

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    Event date: 2020.9

  33. マイクロ流体デバイスを用いた蛍光相関分光法による一様微小隙間での潤滑剤粘度計測

    長谷川 奨,木本 貴幸,福澤 健二,伊藤 伸太郎,東 直輝,張 賀東

    日本機械学会2020年度年次大会  

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    Event date: 2020.9

  34. ナノ厚さリン脂質ポリマーブラシ膜のずり粘弾性定量化に向けた光干渉縞計測によるせん断すき間同定法

    林 楓昌,伊藤 伸太郎,福澤 健二,張 賀東,東 直輝

    日本機械学会2020年度年次大会  

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    Event date: 2020.9

  35. 反応分子動力学による熱アシスト磁気記録におけるPFPE潤滑膜のメカノケミカル分解解析

    陳星宇,川合健斗,張賀東,福澤健二,伊藤伸太郎,東直輝

    IIP2020 情報・知能・精密機器部門(IIP部門)講演会 講演論文集 

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    Event date: 2020.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  36. DNA1分子サイズ測定のための微小流路内の気液界面の移動を用いた分子の伸長・固定 ~分子伸長率の気液界面の移動速度依存性~

    東 直輝,浅井 泰平,福澤 健二,伊藤 伸太郎,張 賀東

    IIP2021 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2020.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  37. マイクロ流体デバイスと蛍光相関分光法の組み合わせによる一様微小隙間での潤滑剤粘度計測

    木本 貴幸,福澤 健二,伊藤 伸太郎,東 直輝,張 賀東

    IIP2020 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2020.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  38. ナノスリット流路を電気泳動する大分子量DNAの分子伸長とその電圧依存性

    永田春香,伊藤伸太郎,東 直輝,福澤 健二,張 賀東

    IIP2020 情報・知能・精密機器部門(IIP部門)講演会 講演論文集 

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    Event date: 2020.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  39. DNA分子濃縮を用いたナノ隙間手前の分子のトラップ時間の測定

    東直輝, 福澤健二, 伊藤伸太郎, 張賀東

    第10回マイクロ・ナノ工学シンポジウム 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  40. Stretching of DNA Molecules Migrating through a Nanoslit by Electrophoresis and Its Dependence on Voltages International conference

    Haruka NAGATA, Shintaro ITOH, Naoki AZUMA, Kenji FUKUZAWA,

    32nd International Microprocesses and Nanotechnology Conference 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  41. Measurement of Trapping Time of DNA Molecule in Nanofluidic Entropy Trap using DNA Concentration International conference

    Naoki AZUMA Shintaro ITOh, Kenji FUKUZAWA, Hedong ZHANG

    32nd International Microprocesses and Nanotechnology Conference 

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    Event date: 2019.10

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  42. Gap and Shear Rate Dependence of Viscoelasticity of Lubricants with Polymer Additives Sheared in Nano Gap International conference

    Shintaro ITOh, Kenji FUKUZAWA, Ryosuke AOKI, Hedong ZHANG, Naoki AZUMA, Yasushi ONUMA

    2019 STLE Tribology Frontiers Conference 

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    Event date: 2019.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  43. 水和したリン脂質ポリマーブラシの動的ずり粘弾性のせん断隙間依存性(第2報)

    伊藤伸太郎,青山祥子,東坂悠,福澤健二,張賀東,東直輝

    トライボロジー会議2019春 東京 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  44. サイズ排除型マイクロ電気泳動チップによる大分子量DNAのサイズ分離 Invited

    伊藤 伸太郎, 東 直輝

    第13回集積化MEMS技術研究会 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  45. ナノスリットによるDNA 分子濃縮における理論 モデルを用いた印加電圧の最適化

    東 直輝,福澤 健二,伊藤 伸太郎,張 賀東

    IIP2019情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2019.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東洋大学 川越キャンパス   Country:Japan  

  46. ポリイソブチレンを添加したポリアルファオレフィ ン潤滑油のナノ隙間におけるずり粘弾性

    青木亮介,伊藤伸太郎,福澤健二,張賀東,東直輝

    トライボロジー会議2018 秋 伊勢 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  47. 水和したリン脂質ポリマーブラシの動的粘弾性 のせん断隙間依存性

    青山祥子,伊藤伸太郎,福澤健二,張賀東,東直輝

    トライボロジー会議2018 秋 伊勢 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  48. しゅう動痕に形成されたサブミクロン厚さグリー ス膜のファイバーウォブリング法による粘弾性 計測

    穴井達啓,伊藤伸太郎,福澤健二,張賀東,東直輝,根岸秀世

    トライボロジー会議2018 秋 伊勢 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  49. マイクロ流路内に形成したナノスリットによるDNA試料のオンチップ濃縮

    東 直輝, 伊藤 伸太郎, 福澤 健二, 張 賀東

    第8回マイクロ・ナノ工学シンポジウム2017 

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    Event date: 2017.10 - 2017.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  50. サイズ排除型電気泳動チップにうけるパルス駆動を用いた大分子量DNAサイズ分離の高速化

    東 直輝,伊藤 伸太郎,福澤 健二,張 賀東

    IIP2017 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  51. Reduction of Analysis Time in the Size Separation of Large DNA Using Size Exclusion Chromatography-Based Electrophoresis Microchip Driven by Pulsed Electric Field. International conference

    Naoki Azuma, Shintaro Itoh, Kenji Fukuzawa, Hedong Zhang

    29th International Microprocesses and Nanotechnology Conference (MNC2016) 

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    Event date: 2016.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  52. 電気泳動マイクロチップによる大分子量DNAサイズ分離(理論モデル解析に基づく泳動電圧の最適化)

    東 直輝, 伊藤 伸太郎,  福澤 健二, 張 賀東

    IIP2016 情報・知能・精密機器部門(IIP部門)講演会 

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    Event date: 2016.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  53. Separation of Large DNA Molecules by Size Exclusion Chromatography Type Microchip with on-Chip Concentration Structure International conference

    Naoki Azuma,Shintaro Itoh,,Kenji Fukuzawa,Hedong Zhang

    28th International Microprocesses and Nanotechnology Conference(MNC2015) 

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    Event date: 2015.11

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

  54. Improvement of resolution in SEC-type DNA separation microchip by on-chip concentration using nano-slit International conference

    Naoki Azuma, Shintaro Itoh, Yusuke Sugimoto, Kenji Fukuzawa, Hedong Zhang

    2015 JSME-IIP/ASME-ISPS Joint International Conference on Micromechatronics for Information and Precision Equipment (MIPE2015) 

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    Event date: 2015.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Kobe, Japan   Country:Japan  

  55. ナノスリットを用いたオンチップ濃縮によるサイズ排除型DNA分離法の分離能の向上

    東 直輝, 伊藤 伸太郎, 杉本 悠介, 福澤 健二, 張 賀東

    日本機械学会2014年度年次大会 

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    Event date: 2014.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

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Research Project for Joint Research, Competitive Funding, etc. 9

  1. サブマイクロ・ナノすきましゅう動における潤滑油の流れ分布と摩擦力の同時計測法の提案

    2022.2 - 2024.2

    メカトロニクス技術高度化「研究助成」 

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    Authorship:Principal investigator  Grant type:Other

    Grant amount:\2000000 ( Direct Cost: \2000000 )

  2. 病原菌の世界規模でリアルタイムな感染拡大対策の実現

    2022.1 - 2026.3

    世界で活躍できる研究者戦略育成事業 

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\500000 ( Direct Cost: \500000 )

  3. プラズモニックナノ流路を用いたDNA1分子高速解析

    Grant number:JPMJAX21B2  2021.10 - 2024.3

    ACT-X「環境とバイオテクノロジー」 

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    Authorship:Principal investigator 

    Grant amount:\1000000 ( Direct Cost: \1000000 、 Indirect Cost:\300000 )

  4. 3次元センサ構造を作りこんだマイクロ集積化ワイヤ

    Grant number:21K18158  2021.7 - 2024.3

    科学研究費 挑戦的研究(開拓) 

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    Authorship:Coinvestigator(s)  Grant type:Other

    Grant amount:\600000

  5. DNA1分子で数nm精度のDNA編集用タンパク質結合位置特定法

    Grant number:21K14511  2021.4 - 2023.3

    科学研究費 若手研究 

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    Grant type:Competitive

    Grant amount:\1000000 ( Direct Cost: \1000000 、 Indirect Cost:\300000 )

  6. ナノすきま潤滑現象解明のためのすきま分布・流れ分布計測を実現する顕微鏡システム開発

    2021.4 - 2022.3

    服部報公会 工学研究奨励援助金 

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    Grant type:Other

    Grant amount:\1000000 ( Direct Cost: \1000000 )

  7. 集積化マイクロデバイスを用いたナノすきま潤滑の素過程の解明

    Grant number:20H00214  2020.4 - 2023.3

    科学研究費 基盤研究(A) 

  8. ナノすきま摺動におけるすきま形状と潤滑油流れの同時計測法の提案

    2020.4 - 2021.3

    立松財団 一般研究助成 

  9. ナノ構造による1分子操作と光学的超解像法を組み合わせたDNA1分子サイズ分析法

    Grant number:19K21109  2018.4 - 2019.3

    科学研究費 研究活動スタート支援 

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KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. プラズモニックナノ流路を用いたDNA1分子高速解析

    Grant number:JPMJAX21B2  2021.10 - 2024.3

    JST  ACT-X「環境とバイオテクノロジー」 

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    Authorship:Principal investigator 

  2. 3次元センサ構造を作りこんだマイクロ集積化ワイヤ

    Grant number:21K18158  2021.7 - 2024.3

    科学研究費助成事業  挑戦的研究(開拓)

    福澤 健二, 東 直輝

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    Authorship:Coinvestigator(s) 

    本研究では,フレキシブルフィルムを用いた新しい3次元微細構造形成法を提案し,微細フレキシブルワイヤに,3次元構造を用いたマイクロ力学量センサを複数作りこんだマイクロ集積化ワイヤの基盤技術の確立を試みる.これまでフレキシブルフィルムのハンドリングは容易でなかった.3次元構造形成の基本となる2次元構造から3次元構造への変換について,フレキシブルフィルムの柔軟性を逆に生かした新規な方法論を提案し,3次元構造を集積化したフレキシブルワイヤという新しいセンシングデバイスの基盤技術を確立しようとするものである.

  3. DNA1分子で数nm精度のDNA編集用タンパク質結合位置特定法

    Grant number:21K14511  2021.4 - 2023.3

    若手研究  若手研究

    東 直輝

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    Authorship:Principal investigator 

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    本研究は,DNA1分子でCas9タンパク質の結合位置特定を実現する新規手法の提案を目的とする.微小流路内のDNA1分子操作を用いてCas9タンパク質の結合・抽出と分子の伸長・固定を,STORM(Stochastic optical reconstruction microscopy)による光学的超解像法を用いて高精度な結合位置特定を実現する.

  4. 集積化マイクロデバイスを用いたナノすきま潤滑の素過程の解明

    Grant number:20H00214  2020.4 - 2023.3

    科学研究費助成事業  基盤研究(A)

    福澤 健二, 伊藤 伸太郎, 東 直輝

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    Authorship:Coinvestigator(s) 

    材料・加工技術の進歩に対応して,摺動すきまの微小化が要請されているが,ナノすきま潤滑技術は確立されていない.ナノすきまの潤滑剤の特性には平行な摺動面が,互いに平行に相対運動する摺動計測系が求められるが実現は困難であった.本研究では,マイクロマシン技術を用いて摺動部・アクチュエータを集積化した平行平面摺動系を構築する.これを用い摺動時の力計測に加えすきま分布と潤滑液体の流れ場も計測可能な,すきまを精密に規定した潤滑計測法を確立し,ナノすきまでの流体潤滑の素過程解明のための基盤的知見を得る.
    材料・加工技術の進歩による摺動面(軸受け面などのこすれ合いながら動く面)の高精度化は,より微小な摺動すきまでの流体潤滑を可能とし機械性能を革新してきた.材料・加工技術の進歩に対応して,摺動すきまはμmからnmオーダへと微小化が要請されていたが,微小すきまゆえに計測は困難で,ナノすきま潤滑技術は確立されていない.潤滑液体(潤滑剤)の特性はすきまに強く依存するため,すきまを精密に規定した摺動計測が必須であり,それにはナノすきまを介した平行な摺動面が平行に相対運動する摺動計測系が求められる.しかし,ナノすきまでの実現は困難であった.本研究では,マイクロマシン技術を用いて摺動部・アクチュエータを集積化した平行平面摺動系を構築する.これを用い摺動時の力計測に加えすきま分布と潤滑液体の流れ場も計測可能な,すきまを精密に規定した潤滑計測法を確立し,ナノすきまでのせん断流れの発生と圧力(動圧)の発生という流体潤滑の素過程を解明し,ナノすきま流体潤滑の基盤を構築することを目的としている.
    今年度は,しゅう動部・アクチュエータを集積化した平行平面摺動系を実現する集積化潤滑計測デバイスの設計と作製法の開発を行った.摺動により潤滑剤が発生する力が検出可能となるように,デバイス構造を設計した.さらに,シリコン基板を用いてデバイス構造を具現化する作製法,対向してナノすきま摺動面を形成するガラス板および流路を封止するガラス板の加工法も検討し,おおむね形成が可能であることおよび課題を見出した.
    本研究構想の中核は,一様なナノすきま摺動計測を実現するための平行平板摺動系を構成する摺動部・駆動部を集積した集積化潤滑計測デバイスである.本年度は,デバイスの設計と具現化するための作製法を検討し,当初の研究計画どおり,シリコン基板を用いて摺動部・駆動部を集積したデバイスの設計とそれを具現化する作製法,対向してナノすきま摺動面を形成するガラス板の加工法,および流路を封止するガラス板の加工法も検討し,おおむね形成が可能であること,および課題を見出したため.
    昨年度着手した集積化潤滑計測デバイスの作製法の確立とエリプソメトリー顕微鏡によるすきま計測法の確立を図る.それぞれの研究項目を以下のように進める.
    ・マイクロマシン技術を用いた集積化潤滑計測デバイスの構築
    マイクロ流路としゅう動面段差については,当初,ガラスエッチング板へのエッチングを計画していたが,実施したガラスエッチングの試みにより,エッチレートが低い,表面粗さが劣化するなどの問題が生ずることが分かったため,より加工の容易なシリコン基板のエッチングを検討する.この作製法を基本として,集積化潤滑計測デバイスの改良も検討する.また,接着剤を用いずに,ガラス板とシリコン基板の直接接合を可能とする,陽極接合法を用いたガラス板とシリコン基板の接合を試みる.さらに,これに,流路封止用のガラス板を接着し,集積化潤滑計測デバイスの作製法の確立を図る.
    ・エリプソメトリー顕微鏡によるナノ摺動すきま計測
    試料に光を照射し,反射光の偏光状態の変化からすきまを得るエリプソメトリーに基づいたエリプソメトリー顕微鏡で,集積化潤滑計測デバイスの摺動面のナノすきま計測法の確立を図る.すきま分布を輝度に変換し明暗像として得ることで,すきま分布をリアルタイムに得る.レンズの後側焦点面上の光軸からずれた点に照明光を集光し,試料面を斜めかつ平行に照明するという光学系により,ナノすきまのリアルタイム可視化を試みる.

  5. ナノ構造による1分子操作と光学的超解像法を組み合わせたDNA1分子サイズ分析法

    Grant number:19K21109  2018 - 2019

    研究活動スタート支援 

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    Authorship:Principal investigator 

 

Teaching Experience (On-campus) 8

  1. ナノ計測工学セミナー1C

    2021

  2. 機械・航空宇宙工学実験第1

    2021

  3. 機械・航空宇宙工学実験第2

    2021

  4. 機械・航空宇宙工学実験第1

    2020

  5. 機械・航空宇宙工学実験第1

    2019

  6. 数学2及び演習

    2019

  7. 数学2及び演習

    2018

  8. 機械・航空宇宙工学実験第1

    2018

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